CY1121431T1 - Μορια αντισωματος που εχουν ειδικοτητα για τον ανθρωπινο οχ40 - Google Patents
Μορια αντισωματος που εχουν ειδικοτητα για τον ανθρωπινο οχ40Info
- Publication number
- CY1121431T1 CY1121431T1 CY20181101288T CY181101288T CY1121431T1 CY 1121431 T1 CY1121431 T1 CY 1121431T1 CY 20181101288 T CY20181101288 T CY 20181101288T CY 181101288 T CY181101288 T CY 181101288T CY 1121431 T1 CY1121431 T1 CY 1121431T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antibody molecules
- human
- molecules specific
- specific
- specificity
- Prior art date
Links
- 102100022153 Tumor necrosis factor receptor superfamily member 4 Human genes 0.000 title 1
- 101710165473 Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 title 1
- 101000679851 Homo sapiens Tumor necrosis factor receptor superfamily member 4 Proteins 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 102000050320 human TNFRSF4 Human genes 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Neurology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
Abstract
Η εφεύρεση σχετίζεται με μόρια αντισώματος που έχουν ειδικότητα για αντιγονικούς καθοριστές του ανθρώπινου ΟΧ40, θεραπευτικές χρήσεις των μορίων αντισωμάτων και μεθόδους για την παραγωγή των εν λόγω μορίων αντισώματος.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US15303809P | 2009-02-17 | 2009-02-17 | |
PCT/US2010/024377 WO2010096418A2 (en) | 2009-02-17 | 2010-02-17 | Antibody molecules having specificity for human ox40 |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121431T1 true CY1121431T1 (el) | 2020-05-29 |
Family
ID=42634416
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181101288T CY1121431T1 (el) | 2009-02-17 | 2018-12-04 | Μορια αντισωματος που εχουν ειδικοτητα για τον ανθρωπινο οχ40 |
Country Status (34)
Country | Link |
---|---|
US (3) | US8614295B2 (el) |
EP (1) | EP2398498B1 (el) |
JP (2) | JP5782385B2 (el) |
KR (1) | KR101761929B1 (el) |
CN (1) | CN102741287B (el) |
AR (1) | AR075504A1 (el) |
AU (1) | AU2010216152B2 (el) |
BR (1) | BRPI1008692B8 (el) |
CA (1) | CA2751477C (el) |
CL (1) | CL2011001994A1 (el) |
CO (1) | CO6410312A2 (el) |
CY (1) | CY1121431T1 (el) |
DK (1) | DK2398498T3 (el) |
EA (1) | EA037792B1 (el) |
ES (1) | ES2699716T3 (el) |
HR (1) | HRP20181932T1 (el) |
HU (1) | HUE042114T2 (el) |
IL (1) | IL214282A (el) |
LT (1) | LT2398498T (el) |
MA (1) | MA33122B1 (el) |
MX (1) | MX2011008697A (el) |
MY (1) | MY157473A (el) |
NZ (1) | NZ594315A (el) |
PE (1) | PE20120211A1 (el) |
PL (1) | PL2398498T3 (el) |
PT (1) | PT2398498T (el) |
SG (3) | SG173620A1 (el) |
SI (1) | SI2398498T1 (el) |
TN (1) | TN2011000374A1 (el) |
TW (1) | TWI476281B (el) |
UA (1) | UA107341C2 (el) |
UY (1) | UY32451A (el) |
WO (1) | WO2010096418A2 (el) |
ZA (1) | ZA201105500B (el) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2751477C (en) * | 2009-02-17 | 2019-08-27 | Ucb Pharma S.A. | Antibody molecules having specificity for human ox40 |
GB0920127D0 (en) | 2009-11-17 | 2009-12-30 | Ucb Pharma Sa | Antibodies |
ES2649155T3 (es) | 2010-08-23 | 2018-01-10 | Board Of Regents, The University Of Texas System | Anticuerpos anti-OX40 y procedimientos de uso de los mismos |
WO2012088446A1 (en) | 2010-12-22 | 2012-06-28 | Board Of Trustees Of The Leland Stanford Junior University | Superagonists and antagonists of interleukin-2 |
PH12014500089A1 (en) * | 2011-07-11 | 2014-02-17 | Ichnos Sciences SA | Antibodies that bind to ox40 and their uses |
KR101685262B1 (ko) * | 2011-08-23 | 2016-12-21 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | 항-ox40 항체 및 이의 사용 방법 |
GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
UA112203C2 (uk) * | 2011-11-11 | 2016-08-10 | Юсб Фарма С.А. | Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини |
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US20130149351A1 (en) * | 2011-12-09 | 2013-06-13 | University Of Southern California | Polymer scaffolds and their use in the treatment of vision loss |
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