KR101164691B1 - 알쯔하이머 질환과 관련된 중증의 장애를 가진 트랜스제닉동물 - Google Patents

알쯔하이머 질환과 관련된 중증의 장애를 가진 트랜스제닉동물 Download PDF

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Publication number: KR101164691B1
Authority: KR; South Korea
Prior art keywords: animal; protein; glu; leu; val
Prior art date: 2003-10-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

KR1020067006358A

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English (en)

Korean (ko)

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KR20060090988A (ko

Inventor

까띠 까사스 루자오

빠뜨리끄 베누아

로랑 쁘라디에

군터 트렘프

쟝-미쉘 이띠에

베로니끄 블랑샤르-브레지옹

Original Assignee

아벤티스 파마 소시에떼아노님

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-10-02

Filing date

2004-09-27

Publication date

2012-07-11

2004-09-27 Application filed by 아벤티스 파마 소시에떼아노님 filed Critical 아벤티스 파마 소시에떼아노님

2006-08-17 Publication of KR20060090988A publication Critical patent/KR20060090988A/ko

2012-07-11 Application granted granted Critical

2012-07-11 Publication of KR101164691B1 publication Critical patent/KR101164691B1/ko

2024-09-27 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/107—Rabbit
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/0306—Animal model for genetic diseases
- A01K2267/0312—Animal model for Alzheimer's disease
- C—CHEMISTRY; METALLURGY
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KR1020067006358A 2003-10-02 2004-09-27 알쯔하이머 질환과 관련된 중증의 장애를 가진 트랜스제닉동물 Expired - Lifetime KR101164691B1 (ko)

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FR0311578		2003-10-02
FR0311578A FR2860391B1 (fr)	2003-10-02	2003-10-02	Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer
PCT/FR2004/002436 WO2005032244A1 (fr)	2003-10-02	2004-09-27	Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer

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KR101164691B1 true KR101164691B1 (ko)	2012-07-11

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JP (1)	JP4806635B2 (da)
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CN (1)	CN1889826A (da)
AT (1)	ATE471661T1 (da)
AU (1)	AU2004277357B2 (da)
BR (1)	BRPI0415032A (da)
CA (1)	CA2540622C (da)
CY (1)	CY1110788T1 (da)
DE (1)	DE602004027823D1 (da)
DK (1)	DK1670309T3 (da)
ES (1)	ES2347961T3 (da)
FR (1)	FR2860391B1 (da)
IL (1)	IL174726A (da)
MX (2)	MXPA06003685A (da)
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PL (1)	PL1670309T3 (da)
PT (1)	PT1670309E (da)
RU (1)	RU2373707C2 (da)
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ZA (1)	ZA200602670B (da)

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FR2963791B1 (fr) *	2010-08-11	2012-09-21	Assist Publ Hopitaux De Paris	Methode de diagnostic des maladies neurodegeneratives
JPWO2014007367A1 (ja) *	2012-07-05	2016-06-02	国立大学法人東京大学	同一試料中の２種の物質を検出又は測定する方法
JP6583011B2 (ja) *	2016-01-20	2019-10-02	コニカミノルタ株式会社	酸性水溶液を用いた免疫染色スライドの洗浄方法
CN109776665B (zh) *	2019-02-02	2021-02-05	首都医科大学宣武医院	阿尔茨海默病新突变、其稳转细胞模型及医药用途

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FR2798556B1 (fr) *	1999-09-17	2004-02-27	Aventis Pharma Sa	Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux
AU7429400A (en) *	1999-09-17	2001-04-24	Aventis Pharma S.A.	Novel animal model of alzheimer disease with amyloid plaques and mitochondrial dysfunctions
DE60044205D1 (de) *	1999-09-27	2010-05-27	Aventis Pharma Sa	Transgenes tier welches ein mehrfach-mutiertes presenilin-1 exprimiert
AU7699501A (en) *	2000-07-20	2002-02-05	Cephalon Inc	Gene-targeted non-human mammal with human fad presenilin mutation and generational offspring

2003
- 2003-10-02 FR FR0311578A patent/FR2860391B1/fr not_active Expired - Lifetime
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- 2004-09-27 WO PCT/FR2004/002436 patent/WO2005032244A1/fr active Application Filing
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2006
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2010
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Title
NEUROREPORT 14 April 1997, vol.8, no.6, pp1537-1542

Also Published As

Publication number	Publication date
KR20060090988A (ko)	2006-08-17
PL1670309T3 (pl)	2010-11-30
CA2540622C (fr)	2014-01-14
ES2347961T3 (es)	2010-11-26
AU2004277357B2 (en)	2011-11-03
ZA200602670B (en)	2007-07-25
NO334611B1 (no)	2014-04-22
AU2004277357A1 (en)	2005-04-14
PT1670309E (pt)	2010-09-28
RU2006114692A (ru)	2007-11-10
EP1670309B1 (fr)	2010-06-23
DE602004027823D1 (de)	2010-08-05
WO2005032244A1 (fr)	2005-04-14
MXPA06003685A (es)	2006-06-20
JP4806635B2 (ja)	2011-11-02
CN1889826A (zh)	2007-01-03
ATE471661T1 (de)	2010-07-15
CA2540622A1 (fr)	2005-04-14
CY1110788T1 (el)	2015-06-10
EP1670309A1 (fr)	2006-06-21
MXPA06003670A (es)	2006-06-20
BRPI0415032A (pt)	2006-12-12
SI1670309T1 (sl)	2010-11-30
DK1670309T3 (da)	2010-10-25
NO20061954L (no)	2006-06-26
FR2860391A1 (fr)	2005-04-08
RU2373707C2 (ru)	2009-11-27
IL174726A (en)	2013-05-30
IL174726A0 (en)	2006-08-20
FR2860391B1 (fr)	2006-01-27
JP2007507217A (ja)	2007-03-29

Publication	Publication Date	Title
CA2174429C (en)	2011-08-30	Transgenic animals harboring app allele having swedish mutation
US5612486A (en)	1997-03-18	Transgenic animals harboring APP allele having swedish mutation
JPH07132033A (ja)	1995-05-23	アルツハイマー病モデルトランスジェニック動物
JP2001517065A (ja)	2001-10-02	トランスジェニック動物モデルを用いてアルツハイマー病治療薬を同定する方法
JP5070236B2 (ja)	2012-11-07	神経変性性障害のトランスジェニック動物モデル
KR101164691B1 (ko)	2012-07-11	알쯔하이머 질환과 관련된 중증의 장애를 가진 트랜스제닉동물
US7663018B2 (en)	2010-02-16	Tau hyperphosphorylation in transgenic mice expressing the APP double mutation
EP0920495B1 (en)	2008-05-07	Transgenic animal model for alzheimer disease
US7700823B2 (en)	2010-04-20	Transgenic animals exhibiting major disorders related to Alzheimer's disease
JP2000504202A (ja)	2000-04-11	本来のアミロイド前駆体タンパク質欠失トランスジェニック動物

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