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CY1110788T1 - Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer - Google Patents

Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer

Info

Publication number
CY1110788T1
CY1110788T1 CY20101100849T CY101100849T CY1110788T1 CY 1110788 T1 CY1110788 T1 CY 1110788T1 CY 20101100849 T CY20101100849 T CY 20101100849T CY 101100849 T CY101100849 T CY 101100849T CY 1110788 T1 CY1110788 T1 CY 1110788T1
Authority
CY
Cyprus
Prior art keywords
animals
diagnostic
alzheimer disease
important diseases
diseases relating
Prior art date
Application number
CY20101100849T
Other languages
English (en)
Inventor
Louzao Caty Casas
Patrick Benoit
Laurent Pradier
Gunter Tremp
Jean-Michel Itier
Véronique Blanchard-Bregeon
Original Assignee
Aventis Pharma S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma S.A. filed Critical Aventis Pharma S.A.
Publication of CY1110788T1 publication Critical patent/CY1110788T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/107—Rabbit
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2517/00—Cells related to new breeds of animals
    • C12N2517/02—Cells from transgenic animals

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Η παρούσα εφεύρεση αφορά σε διαγονιδιακά ζώα, όχι ανθρώπους, τα οποία παρουσιάζουν σημαντικές διαταραχές σχετικές με την νόσο του Alzheimer. Τα ζώα μπορούν να χρησιμοποιηθούν για την απόδειξη ενώσεων οι οποίες προορίζονται για τη θεραπεία της νόσου του Alzheimer.
CY20101100849T 2003-10-02 2010-09-22 Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer CY1110788T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0311578A FR2860391B1 (fr) 2003-10-02 2003-10-02 Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer
EP04787459A EP1670309B1 (fr) 2003-10-02 2004-09-27 Animaux transgeniques presentant les troubles majeurs lies a la maladie d'alzheimer

Publications (1)

Publication Number Publication Date
CY1110788T1 true CY1110788T1 (el) 2015-06-10

Family

ID=34307379

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100849T CY1110788T1 (el) 2003-10-02 2010-09-22 Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer

Country Status (22)

Country Link
EP (1) EP1670309B1 (el)
JP (1) JP4806635B2 (el)
KR (1) KR101164691B1 (el)
CN (1) CN1889826A (el)
AT (1) ATE471661T1 (el)
AU (1) AU2004277357B2 (el)
BR (1) BRPI0415032A (el)
CA (1) CA2540622C (el)
CY (1) CY1110788T1 (el)
DE (1) DE602004027823D1 (el)
DK (1) DK1670309T3 (el)
ES (1) ES2347961T3 (el)
FR (1) FR2860391B1 (el)
IL (1) IL174726A (el)
MX (2) MXPA06003685A (el)
NO (1) NO334611B1 (el)
PL (1) PL1670309T3 (el)
PT (1) PT1670309E (el)
RU (1) RU2373707C2 (el)
SI (1) SI1670309T1 (el)
WO (1) WO2005032244A1 (el)
ZA (1) ZA200602670B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2963791B1 (fr) * 2010-08-11 2012-09-21 Assist Publ Hopitaux De Paris Methode de diagnostic des maladies neurodegeneratives
JPWO2014007367A1 (ja) * 2012-07-05 2016-06-02 国立大学法人 東京大学 同一試料中の２種の物質を検出又は測定する方法
JP6583011B2 (ja) * 2016-01-20 2019-10-02 コニカミノルタ株式会社 酸性水溶液を用いた免疫染色スライドの洗浄方法
CN109776665B (zh) * 2019-02-02 2021-02-05 首都医科大学宣武医院 阿尔茨海默病新突变、其稳转细胞模型及医药用途

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2798556B1 (fr) * 1999-09-17 2004-02-27 Aventis Pharma Sa Nouveau modele animal de la maladie d'alzheimer presentant a la fois des plaques amyloides et des dysfonctionnements mitochondriaux
JP2003509071A (ja) * 1999-09-17 2003-03-11 アバンテイス・フアルマ・エス・アー アミロイド斑およびミトコンドリア機能障害を示すアルツハイマー病の新規の動物モデル
EP1255437B1 (fr) * 1999-09-27 2010-04-14 Aventis Pharma S.A. Animal transgenique exprimant une forme multi-mutee de la preseniline 1
JP5046413B2 (ja) * 2000-07-20 2012-10-10 セフアロン・インコーポレーテツド ヒトｆａｄプレセニリン突然変異をもつ標的遺伝子組換え非ヒト哺乳動物および生殖による子孫

Also Published As

Publication number Publication date
AU2004277357B2 (en) 2011-11-03
PL1670309T3 (pl) 2010-11-30
ATE471661T1 (de) 2010-07-15
CA2540622C (fr) 2014-01-14
CA2540622A1 (fr) 2005-04-14
MXPA06003685A (es) 2006-06-20
KR20060090988A (ko) 2006-08-17
CN1889826A (zh) 2007-01-03
ES2347961T3 (es) 2010-11-26
IL174726A0 (en) 2006-08-20
DE602004027823D1 (de) 2010-08-05
KR101164691B1 (ko) 2012-07-11
ZA200602670B (en) 2007-07-25
RU2006114692A (ru) 2007-11-10
JP4806635B2 (ja) 2011-11-02
DK1670309T3 (da) 2010-10-25
EP1670309B1 (fr) 2010-06-23
JP2007507217A (ja) 2007-03-29
MXPA06003670A (es) 2006-06-20
NO334611B1 (no) 2014-04-22
PT1670309E (pt) 2010-09-28
NO20061954L (no) 2006-06-26
BRPI0415032A (pt) 2006-12-12
RU2373707C2 (ru) 2009-11-27
AU2004277357A1 (en) 2005-04-14
FR2860391A1 (fr) 2005-04-08
WO2005032244A1 (fr) 2005-04-14
SI1670309T1 (sl) 2010-11-30
EP1670309A1 (fr) 2006-06-21
IL174726A (en) 2013-05-30
FR2860391B1 (fr) 2006-01-27

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