JPS6034556B2 - 抗生物質ｃ−１５００３ - Google Patents

抗生物質ｃ−１５００３

Info

Publication number: JPS6034556B2
Authority: JP; Japan
Prior art keywords: antibiotic; ethyl acetate; culture; medium; water
Prior art date: 1977-03-31
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP52037166A

Other languages

English (en)

Japanese (ja)

Other versions

JPS53130693A (en

Inventor

栄治東出

満子浅井

清一谷田

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Takeda Pharmaceutical Co Ltd

Original Assignee

Takeda Chemical Industries Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1977-03-31

Filing date

1977-03-31

Publication date

1985-08-09

1977-03-31 Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd

1977-03-31 Priority to JP52037166A priority Critical patent/JPS6034556B2/ja

1977-06-29 Priority to US05/811,448 priority patent/US4162940A/en

1977-09-23 Priority to AU29074/77A priority patent/AU510499B2/en

1977-09-23 Priority to AU29072/77A priority patent/AU506415B2/en

1977-10-04 Priority to PH20297A priority patent/PH13381A/en

1977-10-07 Priority to FR7730339A priority patent/FR2385714A1/fr

1977-10-07 Priority to SU772529301A priority patent/SU741804A3/ru

1977-10-11 Priority to GR54548A priority patent/GR66051B/el

1977-10-12 Priority to YU02453/77A priority patent/YU245377A/xx

1977-10-13 Priority to CS776678A priority patent/CS214749B2/cs

1977-10-13 Priority to SE7711542A priority patent/SE442873B/xx

1977-10-13 Priority to NL7711272A priority patent/NL7711272A/xx

1977-10-13 Priority to HU77TA1459A priority patent/HU178359B/hu

1977-10-13 Priority to HU802440A priority patent/HU187372B/hu

1977-10-13 Priority to NLAANVRAGE7711274,A priority patent/NL188102C/xx

1977-10-14 Priority to CA288,731A priority patent/CA1107212A/fr

1977-10-14 Priority to DE19772746252 priority patent/DE2746252A1/de

1977-10-14 Priority to DE19772746209 priority patent/DE2746209A1/de

1977-10-14 Priority to ES463207A priority patent/ES463207A1/es

1977-10-14 Priority to DK458877A priority patent/DK458877A/da

1977-10-14 Priority to GB42823/77A priority patent/GB1592264A/en

1977-10-14 Priority to IE2101/77A priority patent/IE46064B1/en

1977-10-14 Priority to AT0736277A priority patent/AT364081B/de

1977-10-14 Priority to GB42822/77A priority patent/GB1586688A/en

1977-10-15 Priority to PL1977201541A priority patent/PL122289B1/pl

1977-10-15 Priority to PL1977221358A priority patent/PL124349B1/pl

1978-01-01 Priority to CH1260577A priority patent/CH637137A5/de

1978-03-30 Priority to IT21818/78A priority patent/IT1094308B/it

1978-03-30 Priority to PT67854A priority patent/PT67854B/pt

1978-03-30 Priority to IT21817/78A priority patent/IT1094020B/it

1978-03-31 Priority to ZA00781862A priority patent/ZA781862B/xx

1978-03-31 Priority to ZA00781863A priority patent/ZA781863B/xx

1978-03-31 Priority to BE186486A priority patent/BE865589A/fr

1978-03-31 Priority to BE186487A priority patent/BE865590A/fr

1978-06-20 Priority to SU782627804A priority patent/SU890978A3/ru

1978-07-31 Priority to ES472230A priority patent/ES472230A1/es

1978-11-14 Publication of JPS53130693A publication Critical patent/JPS53130693A/ja

1978-11-17 Priority to AT822678A priority patent/AT362061B/de

1978-12-22 Priority to US05/972,492 priority patent/US4225494A/en

1979-02-20 Priority to PH22216A priority patent/PH15985A/en

1980-03-19 Priority to US06/131,787 priority patent/US4320200A/en

1980-08-06 Priority to DK338880A priority patent/DK148180B/da

1981-03-20 Priority to CA000373582A priority patent/CA1121814A/fr

1981-10-22 Priority to US06/313,974 priority patent/US4360462A/en

1982-08-17 Priority to YU01785/82A priority patent/YU178582A/xx

1983-05-03 Priority to SE8302517A priority patent/SE446004B/sv

1985-08-09 Publication of JPS6034556B2 publication Critical patent/JPS6034556B2/ja

Status Expired legal-status Critical Current

Links

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239000002609 medium Substances 0.000 claims description 28
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238000004519 manufacturing process Methods 0.000 claims description 7
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XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 117
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238000012258 culturing Methods 0.000 description 6
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239000003242 anti bacterial agent Substances 0.000 description 4
229940088710 antibiotic agent Drugs 0.000 description 4
239000013058 crude material Substances 0.000 description 4
239000012153 distilled water Substances 0.000 description 4
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QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
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241000699670 Mus sp. Species 0.000 description 3
229910002651 NO3 Inorganic materials 0.000 description 3
NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 3
238000005273 aeration Methods 0.000 description 3
MQYZCKOGTWYJAZ-UHFFFAOYSA-N ansamitocin P1 Natural products CN1C(=O)CC(OC(C)=O)C2(C)OC2C(C)C(OC(=O)N2)CC2(O)C(OC)C=CC=C(C)CC2=CC(OC)=C(Cl)C1=C2 MQYZCKOGTWYJAZ-UHFFFAOYSA-N 0.000 description 3
SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 3
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238000006731 degradation reaction Methods 0.000 description 3
230000000694 effects Effects 0.000 description 3
150000002148 esters Chemical class 0.000 description 3
235000013312 flour Nutrition 0.000 description 3
235000011187 glycerol Nutrition 0.000 description 3
239000012535 impurity Substances 0.000 description 3
229910052742 iron Inorganic materials 0.000 description 3
230000000813 microbial effect Effects 0.000 description 3
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239000002244 precipitate Substances 0.000 description 3
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Engineering & Computer Science (AREA)
Oncology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Compounds Of Unknown Constitution (AREA)

JP52037166A 1977-03-31 1977-03-31 抗生物質ｃ−１５００３ Expired JPS6034556B2 (ja)

Priority Applications (45)

Application Number	Priority Date	Filing Date	Title
JP52037166A JPS6034556B2 (ja)	1977-03-31	1977-03-31	抗生物質ｃ−１５００３
US05/811,448 US4162940A (en)	1977-03-31	1977-06-29	Method for producing Antibiotic C-15003 by culturing nocardia
AU29074/77A AU510499B2 (en)	1977-03-31	1977-09-23	Antibiotic 0-15003
AU29072/77A AU506415B2 (en)	1977-03-31	1977-09-23	Antibiotic c-15003
PH20297A PH13381A (en)	1977-03-31	1977-10-04	Antibiotic c-15003
FR7730339A FR2385714A1 (fr)	1977-03-31	1977-10-07	Nouvel antibiotique denomme c-15003, son procede de preparation et son application comme medicament
SU772529301A SU741804A3 (ru)	1977-03-31	1977-10-07	Способ получени антибиотика
GR54548A GR66051B (fr)	1977-03-31	1977-10-11
YU02453/77A YU245377A (en)	1977-03-31	1977-10-12	Process for producing antibiotics
CS776678A CS214749B2 (en)	1977-03-31	1977-10-13	Means for treating the diseased plants and method of preparation of active substance
SE7711542A SE442873B (sv)	1977-03-31	1977-10-13	Forfarande for framstellning av ett nytt antibiotikum c-15003 med angiven formel genom odling av nocardia no c-15003 (ifo 13726, ferm 3992, atcc 31281)
NL7711272A NL7711272A (nl)	1977-03-31	1977-10-13	Werkwijze ter bereiding van farmaceutische pre- paraten, alsmede gevormde farmaceutische prepa- raten.
HU77TA1459A HU178359B (en)	1977-03-31	1977-10-13	Process for preparing the antibiotic c-15003
HU802440A HU187372B (en)	1977-03-31	1977-10-13	Process for the preparation of c-15003 p-o antibiotic
NLAANVRAGE7711274,A NL188102C (nl)	1977-03-31	1977-10-13	Werkwijze ter bereiding van antibiotica.
GB42822/77A GB1586688A (en)	1977-03-31	1977-10-14	Antibiotic c-15003
DE19772746252 DE2746252A1 (de)	1977-03-31	1977-10-14	Antibiotikum c-15003 enthaltendes arzneimittel zur behandlung von tumore aufweisenden warmbluetern
DE19772746209 DE2746209A1 (de)	1977-03-31	1977-10-14	Neues antibiotikum und verfahren zu dessen herstellung
ES463207A ES463207A1 (es)	1977-03-31	1977-10-14	Un metodo para producir el antibiotico c-15003
DK458877A DK458877A (da)	1977-03-31	1977-10-14	Antibiotika
GB42823/77A GB1592264A (en)	1977-03-31	1977-10-14	Treatment of tumor-carrying animal with antibiotic c-15003
IE2101/77A IE46064B1 (en)	1977-03-31	1977-10-14	Antibiotic c-15003
AT0736277A AT364081B (de)	1977-03-31	1977-10-14	Verfahren zur herstellung von neuen antibiotika
CA288,731A CA1107212A (fr)	1977-03-31	1977-10-14	C-15003 antibiotique
PL1977201541A PL122289B1 (en)	1977-03-31	1977-10-15	Process for preparing novel antibiotic
PL1977221358A PL124349B1 (en)	1977-03-31	1977-10-15	Process for preparing maytansinol
CH1260577A CH637137A5 (en)	1977-03-31	1978-01-01	Antibiotic and process for its preparation
IT21818/78A IT1094308B (it)	1977-03-31	1978-03-30	Composizione antibiotica e relativo frocedimento di trattamento di animali affetti da tumori
PT67854A PT67854B (en)	1977-03-31	1978-03-30	Antibiotic c-15003
IT21817/78A IT1094020B (it)	1977-03-31	1978-03-30	Antibioticc c-15003 e procedimento per la produzione di esso e dei relativi derivati
ZA00781863A ZA781863B (en)	1977-03-31	1978-03-31	Treatment of tumor-carrying animal with antibiotic c-15003
BE186487A BE865590A (fr)	1977-03-31	1978-03-31	Compositions antibiotiques et leur utilisation
ZA00781862A ZA781862B (en)	1977-03-31	1978-03-31	Antibiotic c-15003
BE186486A BE865589A (fr)	1977-03-31	1978-03-31	Antibiotiques et leur preparation
SU782627804A SU890978A3 (ru)	1977-03-31	1978-06-20	Способ получени антибиотика с-1500зр-0
ES472230A ES472230A1 (es)	1977-03-31	1978-07-31	Metodo para producir el antibiotico c-15003 p-o.
AT822678A AT362061B (de)	1977-03-31	1978-11-17	Verfahren zur herstellung eines neuen antibiotikums
US05/972,492 US4225494A (en)	1977-03-31	1978-12-22	Maytansinol esters
PH22216A PH15985A (en)	1977-03-31	1979-02-20	A method for producing maytansinol
US06/131,787 US4320200A (en)	1977-03-31	1980-03-19	Antibiotic
DK338880A DK148180B (da)	1977-03-31	1980-08-06	Fremgangsmaade til fremstilling af maytansinol
CA000373582A CA1121814A (fr)	1977-03-31	1981-03-20	Antibiotique c-15003
US06/313,974 US4360462A (en)	1977-03-31	1981-10-22	Process for preparing maytansinol
YU01785/82A YU178582A (en)	1977-03-31	1982-08-17	Process for obtaining antibiotics
SE8302517A SE446004B (sv)	1977-03-31	1983-05-03	Forfarande for framstellning av antibiotikum c-15003 p-o (maytansinol)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP52037166A JPS6034556B2 (ja)	1977-03-31	1977-03-31	抗生物質ｃ−１５００３

Publications (2)

Publication Number	Publication Date
JPS53130693A JPS53130693A (en)	1978-11-14
JPS6034556B2 true JPS6034556B2 (ja)	1985-08-09

Family

ID=12490004

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP52037166A Expired JPS6034556B2 (ja)	1977-03-31	1977-03-31	抗生物質ｃ−１５００３

Country Status (6)

Country	Link
JP (1)	JPS6034556B2 (fr)
AT (1)	AT364081B (fr)
BE (2)	BE865589A (fr)
HU (1)	HU187372B (fr)
SU (2)	SU741804A3 (fr)
ZA (2)	ZA781863B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7432088B2 (en) *	2003-05-08	2008-10-07	Immunogen Inc.	Methods for the production of ansamitocins
SI2900676T1 (sl) *	2012-09-26	2019-04-30	Immunogen, Inc.	Izboljšana metoda za aciliranje majtanzinola
CN116421733B (zh) *	2023-06-08	2023-09-12	金宇保灵生物药品有限公司	可用于猪多杀性巴氏杆菌病活疫苗的疫苗耐热保护剂

1977
- 1977-03-31 JP JP52037166A patent/JPS6034556B2/ja not_active Expired
- 1977-10-07 SU SU772529301A patent/SU741804A3/ru active
- 1977-10-13 HU HU802440A patent/HU187372B/hu unknown
- 1977-10-14 AT AT0736277A patent/AT364081B/de not_active IP Right Cessation
1978
- 1978-03-31 BE BE186486A patent/BE865589A/fr not_active IP Right Cessation
- 1978-03-31 ZA ZA00781863A patent/ZA781863B/xx unknown
- 1978-03-31 BE BE186487A patent/BE865590A/fr not_active IP Right Cessation
- 1978-03-31 ZA ZA00781862A patent/ZA781862B/xx unknown
- 1978-06-20 SU SU782627804A patent/SU890978A3/ru active

Also Published As

Publication number	Publication date
BE865589A (fr)	1978-10-02
JPS53130693A (en)	1978-11-14
HU187372B (en)	1985-12-28
SU890978A3 (ru)	1981-12-15
ZA781863B (en)	1979-03-28
BE865590A (fr)	1978-10-02
ZA781862B (en)	1979-03-28
ATA736277A (de)	1981-02-15
AT364081B (de)	1981-09-25
SU741804A3 (ru)	1980-06-15

Publication	Publication Date	Title
JPS6253158B2 (fr)	1987-11-09
JPS6016236B2 (ja)	1985-04-24	抗生物質ｃ―１５００３ｐ―３の製造法
KR960016874B1 (ko)	1996-12-23	미생물에 의한 트랜스-4-히드록시-l-프롤린의 제조방법
JPS6010718B2 (ja)	1985-03-19	メイタンシノ−ル，メイタナシンおよびメイタンシノ−ル・プロピオネ−トの製造法
US4764602A (en)	1988-08-16	Antibiotics, and their production
JPS6034556B2 (ja)	1985-08-09	抗生物質ｃ−１５００３
JPH0366302B2 (fr)	1991-10-16
US4550021A (en)	1985-10-29	Antitumor antibiotic 81-484 and process for its production
JPS6010720B2 (ja)	1985-03-19	抗生物質ｃ―１５００３ｐ―４の製造法
US4332902A (en)	1982-06-01	Antibiotic substance
US4292309A (en)	1981-09-29	Antibiotics C-14482 B1, B2 and B3
KR810001056B1 (ko)	1981-09-07	항생물질 c-15003의 제조법
KR810000510B1 (ko)	1981-05-25	메이탄시노올 유도체의 제조방법
JPS6210048A (ja)	1987-01-19	新規生理活性物質ｍｈ４３５
KR830001245B1 (ko)	1983-06-27	항생물질 마이코플라네신의 제조방법
KR820001433B1 (ko)	1982-08-14	항생물질 c-15003 p-4의 제조법
JP4235298B2 (ja)	2009-03-11	抗生物質パレイン酸ａとその製造法
JPH0337559B2 (fr)	1991-06-05
JPS6016237B2 (ja)	1985-04-24	抗生物質ｃ―１５００３ｐ―２の製造法
KR810002039B1 (ko)	1981-12-21	항생물질 c-14919e-1 및 e-2의 제조방법
JPH03240495A (ja)	1991-10-25	新規生理活性物質サイクロオクタチン、その製造法およびその用途
JPH0372618B2 (fr)	1991-11-19
JPS62186787A (ja)	1987-08-15	新規な微生物
JPS6348284A (ja)	1988-02-29	新抗生物質ｙｐ−０２９０８ｌ−ａおよびその製造法
JPS5918035B2 (ja)	1984-04-25	抗生物質ａｂ−８５