JPS5817466B2 - 〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法 - Google Patents

〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法

Info

Publication number: JPS5817466B2
Authority: JP; Japan
Prior art keywords: imidazolyl; compound; acid; salts; chlorophenyl
Prior art date: 1974-06-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

JP50073251A

Other languages

English (en)

Japanese (ja)

Other versions

JPS5113769A (en

Inventor

クレマ− ボルフガンク

ハインツビユツヘルカ−ル

プレンペルマンフレツト

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Bayer AG

Original Assignee

Bayer AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1974-06-20

Filing date

1975-06-18

Publication date

1983-04-07

1975-06-18 Application filed by Bayer AG filed Critical Bayer AG

1976-02-03 Publication of JPS5113769A publication Critical patent/JPS5113769A/ja

1983-04-07 Publication of JPS5817466B2 publication Critical patent/JPS5817466B2/ja

Status Expired legal-status Critical Current

Links

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201000003984 candidiasis Diseases 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
239000008112 carboxymethyl-cellulose Substances 0.000 description 1
239000000969 carrier Substances 0.000 description 1
229960000541 cetyl alcohol Drugs 0.000 description 1
150000005827 chlorofluoro hydrocarbons Chemical class 0.000 description 1
229960004022 clotrimazole Drugs 0.000 description 1
VNFPBHJOKIVQEB-UHFFFAOYSA-N clotrimazole Chemical compound ClC1=CC=CC=C1C(N1C=NC=C1)(C=1C=CC=CC=1)C1=CC=CC=C1 VNFPBHJOKIVQEB-UHFFFAOYSA-N 0.000 description 1
239000003086 colorant Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
238000002425 crystallisation Methods 0.000 description 1
230000008025 crystallization Effects 0.000 description 1
201000003929 dermatomycosis Diseases 0.000 description 1
238000010790 dilution Methods 0.000 description 1
239000012895 dilution Substances 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
239000003995 emulsifying agent Substances 0.000 description 1
239000003623 enhancer Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
229940093499 ethyl acetate Drugs 0.000 description 1
239000010642 eucalyptus oil Substances 0.000 description 1
229940044949 eucalyptus oil Drugs 0.000 description 1
238000002474 experimental method Methods 0.000 description 1
239000003925 fat Substances 0.000 description 1
235000019197 fats Nutrition 0.000 description 1
150000004665 fatty acids Chemical class 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
239000008098 formaldehyde solution Substances 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000012458 free base Substances 0.000 description 1
239000001530 fumaric acid Substances 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
150000002334 glycols Chemical class 0.000 description 1
125000005843 halogen group Chemical group 0.000 description 1
238000010438 heat treatment Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
150000002460 imidazoles Chemical class 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
229940079865 intestinal antiinfectives imidazole derivative Drugs 0.000 description 1
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
239000004310 lactic acid Substances 0.000 description 1
235000014655 lactic acid Nutrition 0.000 description 1
239000008101 lactose Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
239000011976 maleic acid Substances 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
229960002509 miconazole Drugs 0.000 description 1
230000002906 microbiologic effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
235000019813 microcrystalline cellulose Nutrition 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
238000002156 mixing Methods 0.000 description 1
CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 description 1
238000000465 moulding Methods 0.000 description 1
208000030194 mouth disease Diseases 0.000 description 1
NCXMLFZGDNKEPB-FFPOYIOWSA-N natamycin Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C[C@@H](C)OC(=O)/C=C/[C@H]2O[C@@H]2C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 NCXMLFZGDNKEPB-FFPOYIOWSA-N 0.000 description 1
229960003255 natamycin Drugs 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 description 1
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
239000000312 peanut oil Substances 0.000 description 1
239000002304 perfume Substances 0.000 description 1
230000003285 pharmacodynamic effect Effects 0.000 description 1
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
229960004063 propylene glycol Drugs 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
239000011541 reaction mixture Substances 0.000 description 1
230000009467 reduction Effects 0.000 description 1
230000004044 response Effects 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
229960004889 salicylic acid Drugs 0.000 description 1
238000000926 separation method Methods 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
125000005624 silicic acid group Chemical class 0.000 description 1
235000017557 sodium bicarbonate Nutrition 0.000 description 1
229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
238000001179 sorption measurement Methods 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000010902 straw Substances 0.000 description 1
239000000758 substrate Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
238000012360 testing method Methods 0.000 description 1
BSYVTEYKTMYBMK-UHFFFAOYSA-N tetrahydrofurfuryl alcohol Chemical compound OCC1CCCO1 BSYVTEYKTMYBMK-UHFFFAOYSA-N 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000001988 toxicity Effects 0.000 description 1
231100000419 toxicity Toxicity 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
ILWRPSCZWQJDMK-UHFFFAOYSA-N triethylazanium;chloride Chemical compound Cl.CCN(CC)CC ILWRPSCZWQJDMK-UHFFFAOYSA-N 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

JP50073251A 1974-06-20 1975-06-18 〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法 Expired JPS5817466B2 (ja)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE2429513A DE2429513A1 (de)	1974-06-20	1974-06-20	Eckige klammer auf 1-imidazolyl-(1) eckige klammer zu-eckige klammer auf 2-(4'(4''-chlorphenyl)-phenoxy eckige klammer zu -4,4-dimethyl-pentan-3-on und seine salze, ein verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2429513		1974-06-20

Publications (2)

Publication Number	Publication Date
JPS5113769A JPS5113769A (en)	1976-02-03
JPS5817466B2 true JPS5817466B2 (ja)	1983-04-07

Family

ID=5918460

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP50073251A Expired JPS5817466B2 (ja)	1974-06-20	1975-06-18	〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法

Country Status (23)

Country	Link
JP (1)	JPS5817466B2 (fr)
AR (1)	AR205746A1 (fr)
AT (1)	AT340410B (fr)
BE (1)	BE830413A (fr)
CA (1)	CA1048512A (fr)
CH (1)	CH617682A5 (fr)
DD (1)	DD121939A5 (fr)
DE (1)	DE2429513A1 (fr)
DK (1)	DK137644C (fr)
EG (1)	EG11806A (fr)
ES (1)	ES438717A1 (fr)
FI (1)	FI751818A (fr)
FR (1)	FR2275204A1 (fr)
GB (1)	GB1456180A (fr)
IE (1)	IE41167B1 (fr)
IL (1)	IL47502A (fr)
LU (1)	LU72761A1 (fr)
NL (1)	NL7507326A (fr)
NO (1)	NO140009C (fr)
PH (1)	PH11567A (fr)
PL (1)	PL94003B1 (fr)
SE (1)	SE7507014L (fr)
ZA (1)	ZA753934B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3019049A1 (de) *	1980-05-19	1981-12-03	Basf Ag, 6700 Ludwigshafen	Neue azolverbindungen

1974
- 1974-06-20 DE DE2429513A patent/DE2429513A1/de not_active Withdrawn
1975
- 1975-01-01 AR AR259254A patent/AR205746A1/es active
- 1975-05-20 GB GB2151675A patent/GB1456180A/en not_active Expired
- 1975-05-30 CA CA75228121A patent/CA1048512A/fr not_active Expired
- 1975-06-06 NO NO75752017A patent/NO140009C/no unknown
- 1975-06-14 EG EG347A patent/EG11806A/xx active
- 1975-06-16 ZA ZA00753934A patent/ZA753934B/xx unknown
- 1975-06-17 PH PH17274A patent/PH11567A/en unknown
- 1975-06-17 IL IL7547502A patent/IL47502A/xx unknown
- 1975-06-18 DD DD186730A patent/DD121939A5/xx unknown
- 1975-06-18 JP JP50073251A patent/JPS5817466B2/ja not_active Expired
- 1975-06-18 FI FI751818A patent/FI751818A/fi not_active Application Discontinuation
- 1975-06-18 SE SE7507014A patent/SE7507014L/xx unknown
- 1975-06-18 LU LU72761A patent/LU72761A1/xx unknown
- 1975-06-18 AT AT467175A patent/AT340410B/de not_active IP Right Cessation
- 1975-06-18 CH CH793175A patent/CH617682A5/de not_active IP Right Cessation
- 1975-06-18 PL PL1975181326A patent/PL94003B1/pl unknown
- 1975-06-19 ES ES438717A patent/ES438717A1/es not_active Expired
- 1975-06-19 DK DK278475A patent/DK137644C/da active
- 1975-06-19 NL NL7507326A patent/NL7507326A/xx not_active Application Discontinuation
- 1975-06-19 BE BE157481A patent/BE830413A/fr unknown
- 1975-06-19 IE IE1369/75A patent/IE41167B1/xx unknown
- 1975-06-20 FR FR7519416A patent/FR2275204A1/fr active Granted

Also Published As

Publication number	Publication date
IL47502A0 (en)	1975-08-31
SE7507014L (sv)	1975-12-22
DE2429513A1 (de)	1976-01-15
ATA467175A (de)	1977-04-15
IL47502A (en)	1978-06-15
DD121939A5 (fr)	1976-09-05
NO140009B (no)	1979-03-12
NO752017L (fr)	1975-12-23
FI751818A (fr)	1975-12-21
NO140009C (no)	1979-06-20
IE41167L (en)	1975-12-20
DK278475A (da)	1975-12-21
ES438717A1 (es)	1977-03-16
AU8222175A (en)	1976-12-23
NL7507326A (nl)	1975-12-23
FR2275204B1 (fr)	1978-10-06
ZA753934B (en)	1976-05-26
BE830413A (fr)	1975-12-19
CA1048512A (fr)	1979-02-13
AT340410B (de)	1977-12-12
CH617682A5 (en)	1980-06-13
GB1456180A (en)	1976-11-17
LU72761A1 (fr)	1976-04-13
DK137644B (da)	1978-04-10
FR2275204A1 (fr)	1976-01-16
DK137644C (da)	1978-09-18
EG11806A (en)	1977-11-30
AR205746A1 (es)	1976-05-31
PH11567A (en)	1978-03-31
JPS5113769A (en)	1976-02-03
IE41167B1 (en)	1979-11-07
PL94003B1 (fr)	1977-07-30

Publication	Publication Date	Title
JPS6019894B2 (ja)	1985-05-18	抗菌剤
KR20010005792A (ko)	2001-01-15	아졸 화합물, 이의 제조 방법 및 용도
JPS59164778A (ja)	1984-09-17	置換ジアゾリルアルキルカルビノ−ル類、その製法および抗糸状菌剤
IE922264A1 (en)	1993-01-13	Novel compounds
JPH01190688A (ja)	1989-07-31	ピロリチジン化合物およびその用途
JP2004509121A (ja)	2004-03-25	チアゾリジン誘導体および抗真菌剤としてのその使用
JPS6330308B2 (fr)	1988-06-17
JPS59206360A (ja)	1984-11-22	抗ウイルス剤
JPS5821605B2 (ja)	1983-05-02	サツキンザイ
JPS61109718A (ja)	1986-05-28	抗糸状菌剤
US4340760A (en)	1982-07-20	Monophenylamine derivatives
HU180630B (en)	1983-03-28	Process for preparing 1,1-diphenyl-2-/1,2,4-triazol-1-yl/-ethan-1-ols
JPS5817467B2 (ja)	1983-04-07	〔１−イミダゾリル−（１）〕−〔１−（４′−（４′′−クロルフエニル）−フエノキシ〕−３，３−ジメチル−ブタン−２−オン及びその塩の製造法
IL44794A (en)	1977-08-31	Antimicrobial compositions containing certain 1,2,4-or 1,2,3-triazolyl o,n-acetal derivatives
JPS59164782A (ja)	1984-09-17	置換１，３−ジアゾリル−２−プロパノ−ル類、その製法および抗糸状菌剤
CS272226B2 (en)	1991-01-15	Method of new lensofuran-2 ylimidazol derivatives production
JPS5817466B2 (ja)	1983-04-07	〔１−イミダゾリル−（１）〕−〔２−（４′−（４′′−クロルフエニル）フエノキシ〕−４，４−ジメチル−ペンタン−３−オン及びその塩の製造法
JPS6030290B2 (ja)	1985-07-16	製薬組成物及び使用
JPS6030673B2 (ja)	1985-07-17	抗かび活性を有するエテニルイミダゾ−ル誘導体、その製造法、およびそれを含む製薬組成物その製造に有用な中間物、およびこの中間物の製造法
JPH0456035B2 (fr)	1992-09-07
JPS61238780A (ja)	1986-10-24	イミダゾール誘導体、その製法およびそれを含有する医薬
JPH02243673A (ja)	1990-09-27	シクロプロピル置換アゾリルメチルカルビノール誘導体、その製造方法及び医薬としてのその用途
JPS58126870A (ja)	1983-07-28	抗糸状菌剤及びその使用
US4755601A (en)	1988-07-05	Nonyl prenyl-N heterocyclics
JPH0625145B2 (ja)	1994-04-06	１−〔（２−フルオロフェニル）（４−フルオロフェニル）フェニルメチル〕−１ｈ−イミダゾール