JPS5699427A - Human urine trypsin inhibitor derivative and its preparation - Google Patents
Human urine trypsin inhibitor derivative and its preparationInfo
- Publication number
- JPS5699427A JPS5699427A JP127880A JP127880A JPS5699427A JP S5699427 A JPS5699427 A JP S5699427A JP 127880 A JP127880 A JP 127880A JP 127880 A JP127880 A JP 127880A JP S5699427 A JPS5699427 A JP S5699427A
- Authority
- JP
- Japan
- Prior art keywords
- huti
- human urine
- peptide
- actions
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:A human urine tripsin inhubitor derivative (M-HUTI) having a molecular weight 62,000, sugar content of 10wt% (calculated as glucose), and an isoelectric point not more than pH3.0, obtained by reacting a human urine tripsin inhibitor (HUTI) with cyanogen bromide.
USE: An anti-inflammatory drug. M-HUTI has higher specific activity than original HUTI, and storng antiplasmin, antikallikrein, and antihyaluronidase actions, and possesses antithrombin actions.
PROCESS: Dried HUTI is dissolved in 70wt% formic acid, etc. to give a solution, to which cyanogen bromide is added in a ratio of 0.1W20mg per mg of dried HUTI, and the reaction is carried out at 10W50°C in a closed state for 1W60hr, to give protein or peptide having homoserine or homoserinelactone as the end group of carbon, and protein or peptide having newly an N-end group.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP127880A JPS5699427A (en) | 1980-01-11 | 1980-01-11 | Human urine trypsin inhibitor derivative and its preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP127880A JPS5699427A (en) | 1980-01-11 | 1980-01-11 | Human urine trypsin inhibitor derivative and its preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JPS5699427A true JPS5699427A (en) | 1981-08-10 |
Family
ID=11496979
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP127880A Pending JPS5699427A (en) | 1980-01-11 | 1980-01-11 | Human urine trypsin inhibitor derivative and its preparation |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS5699427A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62187413A (en) * | 1985-11-22 | 1987-08-15 | レイラス オイ | Medicine for preventing and treating epithelial destruction |
| JPH07316073A (en) * | 1994-05-23 | 1995-12-05 | Green Cross Corp:The | Preventive and therapeutic agent for rotavirus infection |
-
1980
- 1980-01-11 JP JP127880A patent/JPS5699427A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62187413A (en) * | 1985-11-22 | 1987-08-15 | レイラス オイ | Medicine for preventing and treating epithelial destruction |
| JPH07316073A (en) * | 1994-05-23 | 1995-12-05 | Green Cross Corp:The | Preventive and therapeutic agent for rotavirus infection |
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