JPS5640606A - Preparation of stable drug - Google Patents
Preparation of stable drugInfo
- Publication number
- JPS5640606A JPS5640606A JP11660779A JP11660779A JPS5640606A JP S5640606 A JPS5640606 A JP S5640606A JP 11660779 A JP11660779 A JP 11660779A JP 11660779 A JP11660779 A JP 11660779A JP S5640606 A JPS5640606 A JP S5640606A
- Authority
- JP
- Japan
- Prior art keywords
- polyoxyethylene
- pharmaceutical preparation
- carcinostatic
- acylcytosinearabinoside
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title abstract 3
- 229940079593 drug Drugs 0.000 title abstract 3
- -1 polyoxyethylene side chain Polymers 0.000 abstract 6
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 3
- 230000003327 cancerostatic effect Effects 0.000 abstract 3
- 239000004359 castor oil Substances 0.000 abstract 2
- 235000019438 castor oil Nutrition 0.000 abstract 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 2
- 239000000843 powder Substances 0.000 abstract 2
- 239000004094 surface-active agent Substances 0.000 abstract 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 239000001913 cellulose Substances 0.000 abstract 1
- 229920002678 cellulose Polymers 0.000 abstract 1
- 238000000354 decomposition reaction Methods 0.000 abstract 1
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 1
- 239000000194 fatty acid Substances 0.000 abstract 1
- 229930195729 fatty acid Natural products 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- 239000003981 vehicle Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Saccharide Compounds (AREA)
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11660779A JPS5640606A (en) | 1979-09-11 | 1979-09-11 | Preparation of stable drug |
DE3033814A DE3033814C2 (de) | 1979-09-11 | 1980-09-09 | Arzneimittelzubereitung von N↑4-Acylcytosinarabinosiden |
IT49635/80A IT1145416B (it) | 1979-09-11 | 1980-09-09 | Composizione farmaceutica contenente un n4-acil-citosin-arabinoside |
NO802688A NO155088C (no) | 1979-09-11 | 1980-09-10 | Fremgangsmaate for aa forbedre lagringsstabiliteten for et n4-acylcytosinarabinosid. |
NLAANVRAGE8005102,A NL187727C (nl) | 1979-09-11 | 1980-09-10 | Geneesmiddelpreparaat dat een n4-acylcytosine arabinoside bevat en geschikt is voor orale toediening. |
DK384580A DK161491C (da) | 1979-09-11 | 1980-09-10 | Fremgangsmaade til fremstilling af et n4-acylcytosin-arabinosid-praeparat med forbedret kemisk stabilitet og lagringstid |
LU82760A LU82760A1 (fr) | 1979-09-11 | 1980-09-10 | Compositions medicamenteuses |
BE2/58740A BE885161A (nl) | 1979-09-11 | 1980-09-10 | Een n4-acylcytosine arabinoside als actieve component bevattend geneesmiddelpreparaat |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP11660779A JPS5640606A (en) | 1979-09-11 | 1979-09-11 | Preparation of stable drug |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5640606A true JPS5640606A (en) | 1981-04-16 |
Family
ID=14691347
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP11660779A Pending JPS5640606A (en) | 1979-09-11 | 1979-09-11 | Preparation of stable drug |
Country Status (2)
Country | Link |
---|---|
JP (1) | JPS5640606A (ja) |
BE (1) | BE885161A (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5939829A (ja) * | 1982-08-31 | 1984-03-05 | Asahi Chem Ind Co Ltd | ガン壊死因子安定化法 |
JPH05194218A (ja) * | 1991-11-20 | 1993-08-03 | Takeda Chem Ind Ltd | 経口用医薬組成物およびその製造法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5290615A (en) * | 1976-01-19 | 1977-07-30 | Asahi Chem Ind Co Ltd | Water-soluble solid and aqueous solution of n4-acylcytosine arabinosid e |
-
1979
- 1979-09-11 JP JP11660779A patent/JPS5640606A/ja active Pending
-
1980
- 1980-09-10 BE BE2/58740A patent/BE885161A/nl not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5290615A (en) * | 1976-01-19 | 1977-07-30 | Asahi Chem Ind Co Ltd | Water-soluble solid and aqueous solution of n4-acylcytosine arabinosid e |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5939829A (ja) * | 1982-08-31 | 1984-03-05 | Asahi Chem Ind Co Ltd | ガン壊死因子安定化法 |
JPH0375531B2 (ja) * | 1982-08-31 | 1991-12-02 | Asahi Kasei Kogyo Kk | |
JPH05194218A (ja) * | 1991-11-20 | 1993-08-03 | Takeda Chem Ind Ltd | 経口用医薬組成物およびその製造法 |
Also Published As
Publication number | Publication date |
---|---|
BE885161A (nl) | 1981-03-10 |
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