JPS56140947A - Production of coenzyme q - Google Patents
Production of coenzyme qInfo
- Publication number
- JPS56140947A JPS56140947A JP4443380A JP4443380A JPS56140947A JP S56140947 A JPS56140947 A JP S56140947A JP 4443380 A JP4443380 A JP 4443380A JP 4443380 A JP4443380 A JP 4443380A JP S56140947 A JPS56140947 A JP S56140947A
- Authority
- JP
- Japan
- Prior art keywords
- extracted
- coenzyme
- lower alcohol
- extracts
- purified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000005515 coenzyme Substances 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 4
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 abstract 4
- 235000017471 coenzyme Q10 Nutrition 0.000 abstract 4
- 239000000284 extract Substances 0.000 abstract 3
- MYRTYDVEIRVNKP-UHFFFAOYSA-N 1,2-Divinylbenzene Chemical compound C=CC1=CC=CC=C1C=C MYRTYDVEIRVNKP-UHFFFAOYSA-N 0.000 abstract 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 239000007900 aqueous suspension Substances 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 241001465754 Metazoa Species 0.000 abstract 1
- 238000010306 acid treatment Methods 0.000 abstract 1
- 239000003463 adsorbent Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000011148 porous material Substances 0.000 abstract 1
- 230000027756 respiratory electron transport chain Effects 0.000 abstract 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
PURPOSE: An aqueous suspension of an organism containing coenzyme Q is treated with an acid at a specific pH, extracted with a lower alcohol, the filtration residue is heat treated and extracted with a lower alcohol again, and the combination of both extracts are purified to give coenzyme Q inexpesively and efficiently through simple processes.
CONSTITUTION: An aqueous suspension of an organism containing coenzyme Q of the formula (n is 1W12) is adjusted in pH to 1W0.5 with a strong acid to effect acid treatment by heating at 50W100°C for 15W120min. Then, the mixture is neutralized with an alkaline compound and extracted with a lower alcohol and the extract is filtered to separate into the filtrate and the filtration residue. After heat treated at 95W130°C for 15W90min, the residue is extracted again with a lower alcohol. Then, the combination of both extracts is purified with a porous adsorbent that is composed of a copolymer with network structure including pores of 300W1,000Å average size, which is made from mainly styrene and divinylbenzene, to obtain coenzyme Q of the formula that is existing in animals and plants as an essential component for the electron transfer system and shows high pharmaceutical and physiological actions.
COPYRIGHT: (C)1981,JPO&Japio
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4443380A JPS56140947A (en) | 1980-04-03 | 1980-04-03 | Production of coenzyme q |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP4443380A JPS56140947A (en) | 1980-04-03 | 1980-04-03 | Production of coenzyme q |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS56140947A true JPS56140947A (en) | 1981-11-04 |
| JPS627899B2 JPS627899B2 (en) | 1987-02-19 |
Family
ID=12691353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP4443380A Granted JPS56140947A (en) | 1980-04-03 | 1980-04-03 | Production of coenzyme q |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS56140947A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7169590B2 (en) * | 2001-07-16 | 2007-01-30 | Kaneka Corporation | Method of stabilizing reduced coenzyme Q10 and method of acidic crystallization |
| JP5066720B2 (en) * | 2005-04-27 | 2012-11-07 | 国立大学法人豊橋技術科学大学 | Quinone profile method using quinone compounds extracted using compressed carbon dioxide |
-
1980
- 1980-04-03 JP JP4443380A patent/JPS56140947A/en active Granted
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7169590B2 (en) * | 2001-07-16 | 2007-01-30 | Kaneka Corporation | Method of stabilizing reduced coenzyme Q10 and method of acidic crystallization |
| JP5066720B2 (en) * | 2005-04-27 | 2012-11-07 | 国立大学法人豊橋技術科学大学 | Quinone profile method using quinone compounds extracted using compressed carbon dioxide |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS627899B2 (en) | 1987-02-19 |
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