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JPS55162736A - Preparation of m-benzoylbenzaldehyde - Google Patents

Preparation of m-benzoylbenzaldehyde

Info

Publication number
JPS55162736A
JPS55162736A JP6987379A JP6987379A JPS55162736A JP S55162736 A JPS55162736 A JP S55162736A JP 6987379 A JP6987379 A JP 6987379A JP 6987379 A JP6987379 A JP 6987379A JP S55162736 A JPS55162736 A JP S55162736A
Authority
JP
Japan
Prior art keywords
formula
reacting
grignard reagent
pref
hydrolyzing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6987379A
Other languages
Japanese (ja)
Inventor
Genichi Dobashi
Shuichi Mitamura
Katsuyuki Ogura
Isao Hashiba
Kazutaka Arai
Kazuo Endo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nissan Chemical Corp
Sagami Chemical Research Institute
Original Assignee
Nissan Chemical Corp
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nissan Chemical Corp, Sagami Chemical Research Institute filed Critical Nissan Chemical Corp
Priority to JP6987379A priority Critical patent/JPS55162736A/en
Publication of JPS55162736A publication Critical patent/JPS55162736A/en
Pending legal-status Critical Current

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  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PURPOSE: To prepare the title compound useful as a raw material for the safe and high-yield preparation of ketoprofen which is an antiphlogistic analgesic agent, by reacting benzonitrile with a specific Grignard reagent, and hydrolyzing the reaction product under acidic conditions.
CONSTITUTION: The compound of formula III is prepared by (1) reacting a Grignard reagent of formula I (X is Cl, Br or I; R1,2 are lower alkyl or R1 and R2 together form a cyclic alkylene) with benzonitrile pref. in a solvent such as benzene, at 0W100°C, and (2) hydrolyzing the reaction product, without separating the produced imine salt of formula II, under acidic conditions, at 30W100°C. The Grignard reagent of formula I can be obtained by reacting an m-halobenzaldehyde of formula I with metallic magnesium pref. in a solvent such as diethyl ether.
COPYRIGHT: (C)1980,JPO&Japio
JP6987379A 1979-06-06 1979-06-06 Preparation of m-benzoylbenzaldehyde Pending JPS55162736A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6987379A JPS55162736A (en) 1979-06-06 1979-06-06 Preparation of m-benzoylbenzaldehyde

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6987379A JPS55162736A (en) 1979-06-06 1979-06-06 Preparation of m-benzoylbenzaldehyde

Publications (1)

Publication Number Publication Date
JPS55162736A true JPS55162736A (en) 1980-12-18

Family

ID=13415332

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6987379A Pending JPS55162736A (en) 1979-06-06 1979-06-06 Preparation of m-benzoylbenzaldehyde

Country Status (1)

Country Link
JP (1) JPS55162736A (en)

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