JPH11139924A - Cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a cosmetic with low skin irritancy and good feeling when applied, by including specific ether compound(s) and dermal medicinal ingredient(s) which has moisturizing effect, skin whitening effect, antioxidant effect and rough skin ameliorating effect, so as to raise the percutaneous absorbability of the dermal medicinal ingredient(s). SOLUTION: This cosmetic contains (A) at least one kind of a compound of the formula: R<1> -O-(X-O)n -R<2> (R<1> and R<2> are each a 1-24C alkyl; X is a 1-12C alkylene; (n) is 0 or 1; the number of the carbon atoms in R<1> , R<2> and X totals 10-32) and (B) at least one kind of dermal medicinal ingredient e.g. a ceramide of' the formula [R<3> and R<4> are each a (OH-substituted) 8-26C hydrocarbon group], substance with ceramide-like structure, moisturizer, amino acid, plant extract, skin whitening agent, antiinflammatory agent, singlet oxygen scavenger, antioxidant, alcohol compound, sterol, blood circulation promoter}.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a cosmetic composition having an improved percutaneous absorbability of a component having a skin moisturizing effect, a whitening effect, an antioxidant effect and the like.

[0002]

2. Description of the Related Art
BACKGROUND ART In cosmetics and the like, various substances are used as components that exert an effect by transdermal absorption. For example, rough skin,
Skin troubles such as dry skin and aging skin are considered to be caused by a decrease in the water content of the stratum corneum.To improve these troubles, compounds having an amide bond, such as intercellular lipids, particularly Sphingolipids are known to be effective. These compounds are incorporated into cosmetics and the like to enhance the water retention function of the stratum corneum and to improve or prevent rough skin.

[0003] However, it is difficult to obtain a sufficient effect only by blending these compounds in an external preparation because the transdermal absorbability is low. In other words, since the stratum corneum, which is the outermost layer of the skin, originally has a physiological function as a barrier to prevent the invasion of foreign substances from outside the body, it is not sufficient to simply mix such a substance into an external preparation for transdermal use Absorptivity cannot be obtained, and the original function of the component cannot be exhibited.

[0004] In order to improve this, in recent years, dimethylsulfoxide, dimethylformamide, dimethylacetamide,
Transdermal absorption enhancers such as methyldecyl sulfoxide have been used. However, these percutaneous absorption enhancers do not provide a satisfactory percutaneous absorption promotion effect, and may cause erythema on the skin due to strong skin irritation. Was not enough in terms of

Accordingly, the present invention has improved percutaneous absorbability of a skin medicinal ingredient having low skin irritation, good feeling in use, and improving effects such as moisturizing effect, whitening effect, antioxidant effect, and rough skin. The purpose is to provide cosmetics.

[0006]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies in view of the above-mentioned circumstances, and as a result, the percutaneous absorbability of a medicinal ingredient for the skin has been remarkably improved by adding an ether compound having a specific structure, and furthermore, skin irritation has occurred. The inventors have found that there is no such thing, and completed the present invention.

That is, the present invention provides (A) the following general formula (1)

[0008]

[Image Omitted] R ¹ -O- (XO) _n -R ² (1)

(Wherein, R ¹ and R ² are the same or different and each represent a linear, branched or cyclic alkyl group having 1 to 24 carbon atoms, X represents an alkylene group having 1 to 12 carbon atoms,
n represents 0 or 1. A total of 10 to 32 carbon atoms of R ¹ , R ² and X), and (B) one or more skin medicinal ingredients. Offer a fee.

[0010]

DESCRIPTION OF THE PREFERRED EMBODIMENTS Ether compounds used in the present invention
In the general formula (1) showing (A), R¹And R^TwoIs 1 carbon
And 24 to 24 linear, branched or cyclic alkyl groups. This
R out of¹And R^TwoEach preferably has 2 to 22 carbon atoms,
3-20 are particularly preferred. Also R¹, R ^TwoAt least
One of them must be more than two, especially two
Is preferred. Note that R¹And R^TwoAre the same but different
May be.

Specific examples of such R ¹ and R ² include a methyl group, an ethyl group, an n-butyl group, an n-decyl group,
Dodecyl group, n-tetradecyl group, n-octadecyl group, n-eicosyl group, n-tetracosyl group, 1-methylpropyl group, 3-methylhexyl group, 2-methylheptadecyl group, 1,3-dimethylbutyl group, Examples thereof include a 1,3-dimethylpentyl group, a cyclopentyl group, and a cyclohexyl group.

X represents an alkylene group having 1 to 12 carbon atoms, among which those having 1 to 8 carbon atoms are preferable, and specific examples include a methylene group, an ethylene group, and a butylene group. The total carbon number of R ¹ , R ² and X is 10 to 3
2, and preferably from 12 to 28.

N represents 0 or 1, and is particularly preferably 0.

By incorporating such an ether compound (A), the percutaneous absorbability of the medicinal ingredient for the skin is improved and the skin is not irritated.

The ether compound (A) can be produced according to a known method. For example, a direct etherification method of a corresponding alcohol and an alkyl halide, an addition reaction of a corresponding alcohol and an olefin in the presence of a Lewis acid catalyst, and an allyl ether obtained by an addition reaction of a corresponding alcohol and an alkyl halide in the presence of an alkali catalyst It can be produced by a reduction method, a method of reducing acetal or ketal generated from the corresponding alcohol and aldehyde or ketone, or the like.

Further, the active ingredient of the skin medicinal ingredient (B) used in the present invention refers to any activity on the skin, for example, moisturizing effect, skin softening effect, whitening effect, anti-inflammatory effect,
It has an antioxidant effect, a blood circulation promoting effect, and the like. Such active ingredients are not particularly limited as long as they are various active ingredients used in ordinary cosmetics, quasi-drugs, pharmaceuticals, and the like. For example, ceramides, ceramide-like structural substances, humectants, amino acids, and plant extracts Whitening agents, anti-inflammatory agents, singlet oxygen scavengers, antioxidants, alcohols, sterols, and blood circulation promoters.

Among these, ceramides are known compounds represented by the following general formula (2).

[0018]

Embedded image

[In the formula, R ³ and R ⁴ are the same or different and each represents a straight-chain or branched-chain saturated or unsaturated hydrocarbon group having 8 to 26 carbon atoms which may be substituted by a hydroxyl group.]

In the formula (2), the hydrocarbon groups represented by R ³ and R ⁴ are linear or branched having 8 to 26 carbon atoms, and may be saturated or unsaturated. Include, octyl, nonyl, decyl, dodecyl, undecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, eicodecyl, heneicosyl, docosyl, tricosyl, tetracosyl, pentacosyl, hexacosyl, nonenyl,
Decenyl, dodecenyl, undecenyl, tridecenyl,
Tetradecenyl, pentadecenyl, hexadecenyl, heptadecenyl, octadecenyl, nonadecenyl, eicosenyl, heneicosenyl, docosenyl, tricosenyl, tetracosenyl, pentacosenyl, hexacosenyl, nonadienyl, decadienyl, dodecadienyl, pentadienyl, didecadienyl, pentadienyl, didecadienyl, pentadienyl, tridecadienyl , Heptadecadienyl, octadecadienyl, nonadecadiethyl, eicosadienyl, heneicosadenyl, docosadienyl, tricosadienyl, tetracosadenyl, pentacosadenyl, hexacosadenyl, 2-hexyldecyl, 2-octylun Decyl, 2-decyltetradecyl, isostearyl group and the like. These hydrocarbon groups may be substituted by one or more hydroxyl groups.

R ³ is preferably a straight-chain alkyl group having 15 to 23 carbon atoms, particularly preferably pentadecyl, heptadecyl and tricosyl groups. R ⁴ is preferably a straight-chain saturated or unsaturated alkyl or alkenyl group having 15 to 23 carbon atoms. The groups are particularly preferably pentadecyl, heptadecyl and pentadecenyl groups. Among the ceramides represented by the general formula (2), particularly preferable compounds are compounds obtained by combining the case where each of R ³ and R ⁴ in the general formula (2) is a group in the above-described particularly preferable range.

The ceramide-like structural substances include those represented by the following general formulas (3) to (7).

[0023]

Embedded image

[In the formula, R ⁵ represents a straight-chain or branched-chain saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ⁶ represents a straight-chain or branched-chain saturated or unsaturated hydrocarbon group having 9 to 25 carbon atoms. Represents an unsaturated hydrocarbon group, Y ¹ and Z ¹ represent a hydrogen atom or a hydroxyl group, a represents a number of 0 or 1, c represents an integer of 0 to 4, b and d represent 0 to 3 Indicates an integer)

[0025]

Embedded image

Wherein R ⁷ and R ⁸ are the same or different and each represent a linear or branched, saturated or unsaturated, optionally hydroxylated hydrocarbon group having 1 to 40 carbon atoms;
R ⁹ represents a linear or branched alkylene group having 1 to 6 carbon atoms or a single bond; R ¹⁰ represents a hydrogen atom;
Represents a linear or branched alkoxy group or a 2,3-dihydroxypropyloxy group. However, when R ⁹ is a single bond, R ¹⁰ is a hydrogen atom. ]

[0027]

Embedded image

[Wherein, R ^7a represents a hydrocarbon group which may be hydroxylated having 4 to 40 carbon atoms, R ^9a represents a linear or branched alkylene group having 3 to 6 carbon atoms,
^10a represents a linear or branched alkoxy group having 1 to 12 carbon atoms. ]

[0029]

Embedded image

Wherein R ⁷ , R ⁸ , R ^9a and R ^10a have the same meaning as described above. ]

[0031]

Embedded image

Wherein R ⁷ , R ⁸ and R ⁹ have the same meaning as described above, and R ^10b is a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or 2,3-epoxypropyl Shows an oxy group. However, when R ⁹ is a single bond, R
^10b is a hydrogen atom. ]

These ceramide-like structural substances can be prepared by a known method [for example, Polish Journal of Chemistry (Po. J. Chem.) 52 , 1059 (19).
78); 52 , 1283 (1978);
Nos. 117421, 54-144308, 54-147937, 62-228048, 63-216852, and JP-A-8-3192.
No. 63].

In the general formula (3), the number of carbon atoms represented by R ⁵ is 1
Examples of the linear or branched saturated or unsaturated hydrocarbon group having 0 to 26 carbon atoms include those having 10 to 26 carbon atoms in R ³ and R ^4.
Examples of the 9 to 25 linear or branched saturated or unsaturated hydrocarbon group represented by R ⁶ include those having 10 to 26 carbon atoms in R ³ and R ⁴ described above. Can be R ⁵ is preferably a straight-chain saturated alkyl group having 12 to 18 carbon atoms, particularly preferably tetradecyl, hexadecyl or octadecyl group, and R ⁶ is preferably a straight-chain saturated alkyl group having 9 to 18 carbon atoms, particularly nonyl, Pentadecyl and heptadecyl groups are preferred. Among the ceramide-like structural substances represented by the general formula (3), a particularly preferable compound is a compound obtained by combining the case where each of R ⁵ and R ^{6 in the} general formula (3) is a group in the above particularly preferable range. It is.

In the general formula (4), the linear or branched, saturated or unsaturated, optionally hydroxylated hydrocarbon groups represented by R ⁷ and R ⁸ having 1 to 40 carbon atoms include: Methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, decyl, undecyl, dodecyl, tridecyl, tetradecyl, pentadecyl, hexadecyl, heptadecyl, octadecyl, nonadecyl, heenaicosyl, docosyl, nonacosyl, triacontyl, isostearyl, isoheptadecyl , 2
-Ethylhexyl, 1-ethylheptyl, 8-heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 2-heptylundecyl, 9-octadecenyl,
1-hydroxynonyl, 1-hydroxypentadecyl,
2-hydroxypentadecyl, 15-hydroxypentadecyl, 11-hydroxyheptadecyl, 11-hydroxy-8-heptadecenyl and the like.

R ⁷ is preferably a linear or branched alkyl or alkenyl group having 8 to 26 carbon atoms, for example, octyl, decyl, dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl, triacontyl, isostearyl, 2-ethylhexyl, 2-heptylundecyl and 9-octadecenyl and the like. Particularly preferred hydrocarbon groups for R ⁷ are linear or branched alkyl groups having 12 to 22 carbon atoms, such as dodecyl, tetradecyl, hexadecyl, octadecyl, docosyl, and methyl-branched isostearyl groups.

R ⁸ is preferably a straight-chain or branched-chain alkyl or alkenyl group having 9 to 25 carbon atoms, such as nonyl, undecyl, tridecyl, pentadecyl, heptadecyl, heneicosyl, nonacosyl, isoheptadecyl, 1-ethylheptyl, 8- Heptadecyl, 8-heptadecenyl, 8,11-heptadecadienyl, 1-hydroxynonyl, 1-hydroxypentadecyl, 2-hydroxypentadecyl, 15-hydroxypentadecyl,
11-hydroxyheptadecyl and 11-hydroxy-
8-heptadecenyl and the like. Particularly preferred hydrocarbon groups for R ⁸ are straight-chain and branched-chain alkyl groups having 11 to 21 carbon atoms, such as undecyl, tridecyl,
Pentadecyl, heptadecyl, heneicosyl and methyl-branched isoheptadecyl groups.

R⁹Is a straight or branched chain having 1 to 6 carbon atoms
Represents an alkylene group or a single bond, as an alkylene group
Is, for example, methylene, ethylene, trimethylene, tetrame
Tylene, pentamethylene, hexamethylene, 1-methyl
Ethylene, 1-methyltrimethylene, 2-methyltrime
Tylene, 1,1-dimethylethylene, 1-ethylethylene
, 1-methyltetramethylene, 2-ethyltrimethyle
And the like. R ⁹Is a straight-chain having 1 to 6 carbon atoms
Alkylene groups are preferred, of which methylene, ethylene
And trimethylene are particularly preferred.

R ¹⁰ represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group. Examples of the alkoxy group include methoxy, ethoxy, propoxy, butoxy and hexyloxy. Octyloxy, decyloxy, 1-methylethoxy and 2-ethylhexyloxy.
R ¹⁰ is preferably a hydrogen atom, an alkoxy group having 1 to 8 carbon atoms and a 2,3-dihydroxypropyloxy group,
Of these, hydrogen atom, methoxy, ethoxy, propoxy,
Butoxy, 1-methylethoxy, 2-ethylhexyloxy and 2,3-dihydroxypropyloxy groups are particularly preferred.

Among the ceramide-like structural substances (4), particularly preferred compounds are those represented by R ⁷ , R ⁸ and R ^{9 in the} general formula (4).
And a compound in which R ¹⁰ is a group in the particularly preferred range described above.

In the general formula (5), the number of carbon atoms represented by R ^7a is 4
Specific examples of the hydrocarbon group which may be hydroxylated include R ⁷ of ceramide-like structural material (4).
And groups excluding methyl, ethyl and propyl from the above, and the same groups as R ⁷ are preferable. Specific examples of the linear or branched alkylene group having 3 to 6 carbon atoms represented by R ^9a include groups obtained by removing methylene and ethylene from the alkylene groups exemplified in R ⁹ of the ceramide-like structural material (4). No. R ^9a is preferably a linear alkylene group having 3 to 6 carbon atoms, and among them, trimethylene is particularly preferable. Examples of the linear or branched alkoxy group having 1 to 12 carbon atoms represented by R ^10a include the same groups as R ¹⁰ of the ceramide-like structural substance (4), and the same groups are preferable.

In the general formula (6), R ⁷ , R ⁸ , R ^9a
And R ^10a have the same meaning as described above, and the same group is preferable.

In the general formula (7), R ⁷ , R ⁸ and R
⁹ shows the same meaning as above, R ^{10 b} is a hydrogen atom, a linear or branched alkoxy group or a 2,3-epoxypropyl group having 1 to 12 carbon atoms. R ⁷ , R ⁸
Specific examples of R ⁹ and R ⁹ include the same groups as in the ceramide-like structural substance (4), and the same groups are preferable. R
Examples of the linear or branched alkoxy group having 1 to 12 carbon atoms of ^10b include the same groups as R ^{10 in} the ceramide-like structural substance (4), and include a hydrogen atom, the same alkoxy group as R ^10, and 2,2. A 3-epoxypropyloxy group is preferred.

These ceramides and ceramide-like structural substances can be used singly or in combination of two or more. Addition of from 20 to 20% by weight, more preferably from 0.1 to 10% by weight, is more preferable in terms of feeling of use, moisturizing effect, prevention and improvement effect of rough skin, prevention and improvement effect of wrinkle formation, and stability.

Of the active ingredients of the skin medicinal ingredient (B) used in the present invention, examples of humectants include glycol, glycerin, glucose, maltose, maltitol, sucrose, fructose, xylitol, sorbitol, and maltotri. Polyhydric alcohols having a moisturizing action such as aose, threitol, erythritol, starch-degrading sugar-reducing alcohol, sorbitol; ethylene glycol, 1,4-butylene glycol, diglycerin, triglycerin, tetraglycerin, 1,3-butylene glycol; Examples include propylene glycol, dipropylene glycol, polyethylene glycol, and 1,3-propanediol.

These humectants can be used alone or in combination of two or more.
%, Preferably 0.01 to 50% by weight, more preferably 0.05 to 20% by weight, when used, moisturizing effect, prevention and improvement effect of wrinkle formation, prevention and improvement effect of rough skin and stability. It is more preferable in terms of properties.

Among the active ingredients of the skin medicinal ingredient (B) used in the present invention, amino acids or salts thereof include, for example, ornithine, tryptophan, lysine, arginine, histidine, canavanine, glutamic acid, aspartic acid, serine and alanine. , Glycine, leucine,
Isoleucine, proline, threonine, valine, methionine, cystine, cysteine, hydroxyproline,
Phenylalanine, tyrosine, hydroxylysine, trimethylglycine, sodium aspartate, potassium aspartate, magnesium aspartate, calcium aspartate, sodium glutamate, potassium glutamate, magnesium glutamate, calcium glutamate, glutamate hydrochloride, cysteine hydrochloride, histidine hydrochloride, Histidine acetate, histidine phosphate, lysine hydrochloride, lysine acetate, ornithine hydrochloride, ornithine acetate, tryptophan hydrochloride, arginine-glutamate, ornithine-glutamate,
Lysine-glutamate, lysine-aspartate,
Ornithine-aspartate, ε-aminocaproic acid, and the like. Of these, arginine, lysine,
Hydroxylysine and histidine are preferred, and arginine is particularly preferred.

These amino acids or salts thereof can be used singly or in combination of two or more. It is preferable to add 0.0001 to 15% by weight in the total composition, and particularly 0.001 to 10% by weight. %, More preferably 0.01 to 8% by weight, because they are more excellent in moisturizing effect, prevention and improvement effect of wrinkle formation, prevention and improvement effect of rough skin, feeling of use and stability.

Among the active ingredients of the skin medicinal ingredient (B) used in the present invention, plant extracts include, for example, Ashitaba, Azuki, Asenyaku, Avocado, Amacha, Amachatur, Altea, Alteca, Arnica, Almond, Aloe , Apricot, nettle, iris, fennel,
Turmeric, age, ogon, oak, ouren, barley, okra, hypericum, odrikosou, ononis, holland mustard, oyster, cuckoo, valerian, birch, gama, chamomile, chamomile, oats, kanzo, kiwan, kiwan , Kukui nuts, gardenia, kumazasa, walnuts,
Keehi, Mulberry, Gunjou, Gentian, Gennoshoko, Thick, Ginseng, Burdock, Sesame, Wheat, Comfrey, Rice, Sasanqua, Saffron, Hawthorn, Sansho, Shiitake mushroom, Jio, Shikon, Shiso, Shinanoki, Shimosukesou, Peony , Ginger, ginger, shobu, birch, watermelon, horsetail, stevia, vegetative, hawthorn, western hawk, biloba, achillea millefolium, mint,
Sage, mallow, senkyu, assembly, mulberry bark,
Soybean, daisou, thyme, tea, clove, cock,
Evening primrose, camellia, camellia, teuchigurumi, touuki, calendula officinalis, tonin, spruce, corn, dokudami, tomato, carrot, garlic, nobara, bakuga,
Mugi Winter, Parsley, Naked Wheat, Adlay, Mentha, Papaya, Hamamelis, Rose, Cypress, Sunflower, Loquat, Coltsfoot, Grape, Placenta, Hazelnut, Loofah, Safflower, Bodaiju, Button, Hop, Macadamia Nuts, Pine, Matsugasa, Malonier, Melissa, melilot, peach, bean sprouts, cornflower, palm, eucalyptus,
Sakura citrus, lily, yokuinin, mugwort, rye, peanut, lavender, apple, litchi, lettuce, lemon, vetch, rosemary, roth, roman chamomile, rinkenko, kinmizukiki, kisasage, asunaro, holtsou, okiokoshi, kisitsu, senshi, Extracts obtained from chickweed, floating grass, sagebrush, ginkgo, kikyo, chrysanthemum, kumazasa, mukuroji, forsythia and the like.

These plant extracts are dried or crushed without drying the whole plant of each plant or one or more portions thereof (hereinafter, referred to as the “form”) such as leaves, bark, roots, branches and the like. After that, it can be obtained by extraction with a solvent at room temperature or under heating, or by using an extraction device such as a Soxhlet extractor. Here, the solvent used is not particularly limited, for example, water; primary alcohols such as methyl alcohol and ethyl alcohol; propylene glycol;
Liquid polyhydric alcohols such as 1,3-butylene glycol;
Liquid fatty acid lower alkyl esters such as ethyl acetate; hydrocarbons such as benzene and hexane; known solvents such as ethyl ether and acetone; these solvents may be used alone or in combination of two or more. it can. Among them, the extraction solvent is ethyl alcohol,
1,3-butylene glycol is preferred.

As a specific example of a preferred extraction method from the drug substance, 1000 ml of 50 v / v% ethanol is added to 100 g of the dried and pulverized product, and extraction is performed for 3 days at room temperature with occasional stirring. The obtained extract is filtered, the filtrate is left at 5 ° C. for 3 days, and then filtered again to obtain a supernatant. The plant extract obtained under the above conditions may be used as it is as an extracted solution. However, if necessary, a plant extract that has been subjected to treatments such as concentration and filtration can be used.

These plant extracts can be used alone or in combination of two or more. It is preferable to add 0.0001 to 20% by weight in the total composition in terms of dry solid content. 0.0001 to 10% by weight, further 0.000
1-5% by weight, moisturizing effect, prevention of wrinkle formation
It is preferable because it has the effect of improving, preventing and improving rough skin, preventing and improving skin swelling, declining elasticity, dullness of complexion, and preventing and improving spots and freckles, and is excellent in use feeling and stability. .

Among these plant extracts, in particular, chamomile, tea, cucumber, clove, liquorice, loquat, spruce, ginseng, peonies, hawthorn, barley winter, ginger, matsukasa, mulberry bark, balsam, incin Using one or two or more plant extracts selected from the extracts of hako, asenyaku, yellow gon, aloe, altea, spiraea, Dutch mustard, kina, comfrey, rosemary and funnel, synergic whitening The effect is enhanced, and it is possible to effectively prevent and improve spots and freckles, as well as to moisturize and prevent rough skin.
The improvement effect can also be significantly increased.

Among these, the chamomile extract is a chamomile [Matricaria chamomilla]
L. (Compositee)] can be obtained as an extract by extracting the flower with water or a hydrophilic organic solvent such as methanol, ethanol, propanol, propylene glycol, 1,3-butylene glycol or a mixture thereof. The extract can be dried and obtained in the form of a dry powder. Extraction with a hydrophilic organic solvent such as castor oil, persic oil, liquid paraffin, soybean oil, isopropyl myristate, lower fatty acid triglyceride, medium fatty acid triglyceride, sunflower oil, neopentyl glycol dicaprate, squalane, or a mixed solvent thereof. Can be obtained. In the present invention, one of the thus obtained chamomile extract
Species or a combination of two or more can be used.

The extract of chamomile generally contains azulene, camazulene, umbelliferone, 7-methoxycoumarin, matricin, maticalin, taraxasterol, lupeol, apiin, chroman, spiroether and the like. Here, a preferable method for extracting chamomile includes, for example, the following method.

The chamomile flowers are dried and minced. After adding squalane thereto and immersing it from room temperature to 50 ° C. with occasional stirring, the extract is separated by pressing to obtain an extract. This extract is filtered to obtain a chamomile extract.

In the case of using these plant extracts, it is preferable to add 0.00001 to 5% by weight in terms of dry solid content in the whole composition, especially from the viewpoint of whitening effect and stability. 0005-3% by weight, 0.001-2
It is preferable that the compounding by weight is sufficient because a sufficient whitening effect, moisturizing effect, skin roughening prevention / improvement effect can be obtained, and excellent feeling in use and stability can be obtained.

[0058] Among the plant extracts, horsetail, gentian, hamamelis, button, cornflower, catalpa,
When one or two or more selected from extracts of asunaro, orthodox, cypress and pheasant are used, synergistically,
Skin aging prevention effect is enhanced, effectively preventing wrinkle formation
In addition to being able to improve, the moisturizing effect and the effect of preventing and improving rough skin can be significantly enhanced.

When using these plant extracts, 0.00001 to 20% of the total composition in terms of dry solids is used.
%, Preferably 0.0001 to 10% by weight.
% By weight, and further 0.0001 to 5% by weight, the effect of preventing and improving sufficient wrinkle formation, skin sticking, weakening of elasticity,
It is preferable because it has effects of preventing and improving dullness of the complexion, moisturizing effect, and preventing and improving rough skin, and is more excellent in use feeling and stability.

Among the skin medicinal ingredients (B) used in the present invention, the whitening agent is not particularly limited as long as it is used in ordinary cosmetics. For example, L-ascorbic acid and its derivatives, hydroquinone Derivatives, kojic acid and its derivatives, placental extracts and the like.

Among these, ascorbic acid and its derivatives are not particularly limited.
L which is a monovalent metal salt of ascorbic acid phosphate
-Ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, divalent metal salt L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt,
L-ascorbic acid phosphate aluminum salt which is a trivalent metal salt, L-ascorbic acid sulfate sodium salt and L-ascorbic acid potassium salt potassium salt which are monovalent metal salts of L-ascorbic acid sulfate L-ascorbic acid sulfate potassium magnesium salt, L-ascorbic acid sulfate calcium salt, trivalent metal salt L-ascorbic acid sulfate aluminum salt, L-ascorbic acid monovalent metal salt L-ascorbic acid -Ascorbic acid sodium salt, L
-Ascorbic acid potassium salt, divalent metal salt L-ascorbate magnesium salt, L-ascorbate calcium salt, trivalent metal salt L-ascorbate aluminum salt and the like can be preferably mentioned.

The hydroquinone derivative is not particularly limited, and examples thereof include a condensate of hydroquinone and a sugar, a condensate of an alkylhydroquinone and a sugar obtained by introducing one alkyl group having 1 to 4 carbon atoms into hydroquinone, and the like. Among these, preferred are, for example, arbutin and the like.

The kojic acid and its derivatives are not particularly limited. For example, kojic acid, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamo Preferred examples include monoesters such as acetate and kojic acid monobenzoate, and diesters such as kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, and kojic acid dioleate.

As the placenta extract, those which are generally marketed as a water-soluble placenta extract and used as cosmetic raw materials can be used. For example, the placenta of mammals such as cows, pigs, and humans can be washed, blood removed, After extraction of water-soluble components through steps such as crushing and freezing, those obtained by further removing impurities can be mentioned.

Among these whitening agents, arbutin,
Kojic acid and a water-soluble placenta extract are preferred.

These whitening agents can be used singly or in combination of two or more. From the viewpoint of whitening effect, emulsion stability and feeling of use, 0.01 to 30% by weight is blended in the whole composition. It is preferable to mix 0.01 to 10% by weight, more preferably 0.01 to 5% by weight, because not only a sufficient whitening effect can be obtained, but also the use feeling and the stability are excellent.

Among the active ingredients of the skin medicinal ingredient (B) used in the present invention, examples of anti-inflammatory agents include glycyrrhizic acid and its salts, glycyrrhetinic acid and its salts, isopropylaminocaproic acid and its salts, allantoin, Lysozyme chloride, guaiazulene, methyl salicylate, γ-oryzanol and the like, among them, glycyrrhetinic acid, stearyl glycyrrhetinate,
Epsilon aminocaproic acid is preferred.

These anti-inflammatory agents can be used alone or in combination of two or more.
% By weight, particularly 0.01 to 2% by weight, more preferably 0.01 to 1% by weight, from which a high effect of preventing and improving wrinkle formation can be obtained, and it is also preferable in terms of usability and stability.

Among the active ingredients of the skin medicinal ingredient (B) used in the present invention, singlet oxygen scavengers or antioxidants include, for example, α-carotene, β-carotene, γ-carotene, lycopene, cryptoxanthin, lutein , Zeaxanthin, isoseaxanthin, rhodoxanthin, capsanthin, crocetin and the like; 1,4-diazacyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenyliso Benzofuran, α-tocopherol, β-tocopherol, γ-tocopherol, d-tocopherol, histidine, tryptophan, methionine, alanine or its alkyl ester; dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid, tannic acid, epicatechin, epica Catechin, epicatechin gallate, tannins such as epi Caro gallate, flavonoids such as rutin and the like. Of these,
Carotene, tocopherol, ascorbic acid, tannic acid, epicatechin gallate, epicarocatechin gallate are preferred.

These singlet oxygen scavengers or antioxidants can be used alone or in combination of two or more. It is preferable to add 0.001 to 5% by weight in the whole composition, and particularly preferable to use 0.1 to 5% by weight. When added in an amount of from 0.01 to 2% by weight, more preferably from 0.01 to 1% by weight, a high effect of preventing and improving the formation of wrinkles is obtained, and it is preferable in terms of feeling of use and stability.

Among the active ingredients of the skin medicinal ingredient (B) used in the present invention, examples of alcohols include higher alcohols and polyhydric alcohols. As higher alcohols, for example, benzyl alcohol, isocetyl alcohol, isostearyl alcohol, behenyl alcohol, hexadecyl alcohol, phenylethyl alcohol, cetanol, stearyl alcohol,
Oleyl alcohol, 2-octyldodecanol, batyl alcohol, 2-hexyldecanol and the like,
Particularly, cetanol and stearyl alcohol are preferable.

These higher alcohols can be used alone or in combination of two or more.
-20% by weight, especially 0.05-1% by weight.
Addition of 0% by weight, more preferably 0.1 to 5% by weight, increases the moisturizing effect, the effect of preventing / improving rough skin, and the effect of preventing / improving wrinkle formation, and is more excellent in use feeling and stability.

The polyhydric alcohol is not particularly restricted but includes, for example, polyglycerin such as glycerin, diglycerin, triglycerin and tetraglycerin, ethylene glycol, 1,3-butylene glycol,
4-butylene glycol, propylene glycol, dipropylene glycol, polyethylene glycol, 1,3
-Propanediol, glucose, maltose, maltitol, sucrose, fructose, xylitol, sorbitol, maltotriose, threitol, erythritol, amylolytic sugar-reducing alcohol, sorbit, polyoxyalkylene alkylglycoside and the like. Of these, glycerin, 1,3-butylene glycol and 1,3-propanediol are particularly preferred.

These polyhydric alcohols can be used alone or in combination of two or more.
It is preferable that the content is 0.01 to 50% by weight.
When added in an amount of from 30 to 30% by weight, and more preferably from 0.1 to 20% by weight, the moisturizing effect, the effect of preventing and improving rough skin and the effect of preventing and improving wrinkle formation are enhanced, and the feeling and stability are more excellent.

Of the active ingredients of the skin medicinal ingredient (B) used in the present invention, sterols include, for example, cholesterol, cholesteryl isostearate, provitamin D ₃ , cambesterol, stegmasteranol, stegmasterol, 5- Dihydrocholesterol, α-spinasterol, palisterol, clionasterol, γ-sitosterol, stegmasterol, salgasterol, apenasterol, ergostanol, sitosterol, corvisterol, chondrilasterol, polyferasterol, haliclonasterol, neos Bongosterol, fucosterol, aptostanol, ergostadienol, ergosterol, 22-dihydroergosterol, brassicasterol, 24-methyleneco Resterol, 5-dihydroergosterol, dehydroergosterol, fungisterol, cholestanol, coprostanol, dimosterol, 7-heterocholesterol, latosterol, 22-dehydrocholesterol, β-sitosterol, cholestatrien-3β-ol, copros Tanol, cholestanol, ergosterol, 7-dehydrocholesterol, 24-dehydrocholestaztan-3β
-All, equilenin, equilin, estrone, 17β
-Estradiol, androst-4-en-3β,
17β-diol, dehydroebiandrosterone, cholesterol alkenyl succinate (JP-A-5-2949)
No. 89). Of these, cholesterol, cholesteryl isostearate and cholesteryl alkenyl succinate are particularly preferred.

These sterols can be used alone or in combination of two or more.
５０50% by weight, preferably 0.005 to
When added in an amount of 30% by weight, more preferably 0.01 to 20% by weight, the moisturizing effect, the effect of preventing / improving rough skin, the effect of preventing / improving wrinkle formation are enhanced, and the feeling and stability are more excellent.

[0077] Among the active ingredients of the skin medicinal ingredient (B) used in the present invention, as a blood circulation promoting agent, those usually used in cosmetics, quasi-drugs, pharmaceuticals and the like can be used as they are. . Particularly, as the compound, esters of vitamin E, nicotinic acid esters or orotic acid esters, which are vasodilators described in JP-A-62-87506, and JP-A-62-195316
JP-A-2005-133, an esterified product of vitamin E which is a peripheral circulation promoting agent, an acetate ester or a succinate ester, and nicotinamide, methyl nicotinate and the like are used.

Examples of plant extracts having a blood circulation promoting effect include extracts specified in the fragrance journal extra edition No. 6 published in 1986 and the fragrance journal extra edition No. 1 published in 1979, for example, Arnica, hawthorn, kina, salvia, bodaiju, panax ginseng, ginger, mannenrow, hypericum, ginkgo, melissa, ononis, malonier, assembly, garlic, chamomile, saim, mint, nettle,
Pepper, ginger, hops, horse chestnut, lavender, carrot, mustard, kei, pine, senkyu,
Elderberry, yamaseri, hasiridokoro, button, bayberry, dokudami, kohone, shibugaki, tokinsenka,
Plant extracts such as gavidinsou, gentian, grape, Hamabofu, Daidai, Yuzu, Shobu, Natsumikan, Hamamelis, Merryloth, Fennel, Sansho, Peonies, Eucalyptus, Artemisia, Emmeiso, Rice, Clara, Shokyo, Clove, etc. are used. Can be

These plant extracts can be obtained by, for example, extracting leaves, roots, stems, flowers, etc. of these plants using water and / or a hydrophilic organic solvent to obtain an extract; And a method for obtaining a powder by freeze-drying, spray-drying, distillation under reduced pressure and the like. As the hydrophilic organic solvent,
For example, methanol, ethanol and the like can be mentioned, and ethanol is particularly preferable. These solvents may be used alone or in combination of two or more, or may be used by mixing water and these hydrophilic organic solvents. The use amount of these extraction solvents is not particularly limited, and the obtained extract can be used as it is or after further concentration and purification.
Also, commercially available products of these plant extracts can be suitably used.

Among these, the compounds are preferably tocopherol nicotinate, tocopherol acetate, and nicotinamide, and the plant extracts are preferably plant extracts, Hypericum perforatum extract, Ginkgo extract, Arnica extract, Kina extract, Hamamelis extract, and Tokinsenka extract. , Marronnier extract, Emperor extract, Salvia extract, Hamabo extract, Sansho extract, rice germ oil, bodaiju extract, ginger tincture, and clove extract are preferred.

These blood circulation promoters can be used alone or in combination of two or more. Usually, as an active ingredient (in the case of a plant extract, as a dry solid content), 0.001 to 10% %, Preferably 0.01 to 5% by weight, more preferably 0.05 to 3% by weight. Prevention / improvement effect of skin swelling, decrease in elasticity, dullness of complexion, moisturizing effect, rough skin. In addition to the effects of preventing and improving the effect of preventing and improving wrinkle formation and preventing and improving the effect of preventing wrinkles and freckles, it is preferable because it is superior in use feeling and stability.

As the active ingredient of the skin medicinal ingredient (B), the above-mentioned various components can be used alone or in combination of two or more, and the total amount is 5 to 60% by weight, particularly 10% by weight in the total composition.
Preferably it is 40% by weight.

Further, the cosmetic of the present invention may contain various optional components usually used in cosmetics, quasi-drugs, pharmaceuticals, etc., in addition to the above essential components, as long as the effects of the present invention are not impaired. They can be appropriately blended. Such optional components include, for example, purified water, ethanol, surfactants, oily components, silicones, fluorinated oils, UV protection agents, powders, oil gelling agents, film-forming agents, sebum secretion inhibitors, and softeners. Agents, pH adjusters and the like.

[0084] Specifically, the surfactant is not particularly limited, and may be a nonionic surfactant, an anionic surfactant,
Any of the amphoteric surfactants and the like can be suitably used. Examples of the nonionic surfactant include polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, fatty acid monoglyceride, and polyoxyethylene sorbitol fatty acid ester. Oxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil alkyl sulfate, polyoxyethylene castor oil, polyoxyethylene alkyl sulfate, polyglycerin fatty acid ester, sucrose fatty acid ester, glycerin fatty acid ester, alkyl phosphate ester, polyoxy Examples include ethylene alkyl phosphate, fatty acid alkali metal salts, and alkyl glyceryl ether.

Examples of the anionic surfactant include a linear or branched alkylbenzene sulfonate, a linear or branched alkyl or alkenyl ether sulfate, an alkyl or alkenyl sulfate having an alkyl or alkenyl group, and an olefin. Sulfonate, alkane sulfonate, unsaturated fatty acid salt, alkyl or alkenyl ether carboxylate, α-sulfofatty acid salt or ester having alkyl or alkenyl group, N-acyl having acyl group and free carboxylic acid residue Examples of the surfactant include amino acid surfactants and mono- or diester phosphate surfactants having an alkyl group or an alkenyl group.

Examples of the amphoteric surfactant include an imidazoline-based amphoteric surfactant having an alkyl group, an alkenyl group, or an acyl group, a carbobetaine-based, an amidobetaine-based, a sulfobetaine-based, a hydroxysulfobetaine-based, or an amidosulfobetaine-based amphoteric surfactant. Surfactants and the like. Further, a polyether-modified silicone,
It is also possible to use a silicone-containing surfactant such as a siloxane derivative described in JP-A-087995, a surfactant having a perfluoroalkyl group, and the like.

When these surfactants are blended,
It is preferable to add 0.01 to 20% by weight, especially 0.1 to 5% by weight in the whole composition.

The oil component is not particularly limited and may be volatile or non-volatile. For example, hydrocarbons such as solid or liquid paraffin, petrolatum, crystal oil, ceresin, ozokerite, montan wax, squalane, squalene, etc. Eucalyptus oil, peppermint oil, camellia oil, macadamia nut oil, avocado oil, tallow, lard,
Horse fat, egg yolk, olive oil, carnauba wax, lanolin, jojoba oil; glycerin monostearate,
Glycerin distearate, glycerin monooleate, isopropyl palmitate, isopropyl stearate, butyl stearate, isopropyl myristate, neopentyl glycol dicaprate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, myristyl lactate ,
Diisopropyl adipate, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoyl glycerol, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, di-2-ethylhexanoate Neopentyl glycol, octyldodecyl oleate, glycerol triisostearate, di-paramethoxycinnamic acid
Ester oils such as glyceryl mono-2-ethylhexanoate; higher fatty acids such as stearic acid, palmitic acid and oleic acid. When these oily components are blended, 0.001 to 50% by weight, particularly 0.1% by weight in the total composition.
It is preferable to mix 005 to 30% by weight.

The silicones are not particularly limited as long as they are usually compounded in cosmetics. For example, octamethylpolysiloxane, tetradecamethylpolysiloxane, methylpolysiloxane, highly polymerized methylpolysiloxane, methyl In addition to phenylpolysiloxane, methylpolycyclosiloxane such as octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane, trimethylsiloxysilicic acid, alkyl-modified silicone, polyether / alkyl-modified silicone, alkylglyceryl ether-modified silicone, Kaihei 6-72
And modified silicones such as the modified organopolysiloxane described in JP-A-851. When these silicones are blended, it is preferable to blend 0.001 to 50% by weight, particularly 0.005 to 30% by weight in the total composition.

As the fluorinated oil, perfluoropolyether which is a perfluoro organic compound which is liquid at ordinary temperature,
Fluorine-modified silicones are preferred. For example, perfluorodecalin, perfluoroadamantane, perfluorobutyltetrahydrofuran, perfluorooctane, perfluorononane, perfluoropentane, perfluorodecane, perfluorododecane, fluorine-modified silicone, a compound represented by the general formula (8) )

[0091]

Embedded image

(Wherein R ¹¹ , R ¹³ , R ¹⁴ and R ¹⁵ may be the same or different and each represents a fluorine atom, a perfluoroalkyl group or a perfluoroalkyloxy group, and R ¹² represents a fluorine atom or a perfluoroalkyl group). A ₁ , b ₁ and c ₁ have a molecular weight of 500 to 100,0
Indicates a number equal to or greater than 0 that is 00. Where a ₁ = b ₁ = c
₁ = 0 never occurs. And the like. Here, the perfluoro groups shown in parentheses need not be arranged in this order, and may be random polymerization or block polymerization. As the perfluoropolyether, a liquid having a viscosity of 5 to 5,000 cs (centistokes) is particularly preferable. For example, the following general formula (9)

[0093]

Embedded image

(Wherein d ₁ and e _{1 each} have a molecular weight of 500 to
The number is 10,000, and d ₁ / e ₁ is 0.2 to 2
It is. ) Represented by FOMBLIN HC-04 (average molecular weight 1,500) and HC-25 (3,200)
And the same HC-R (6,600) (produced by Montefloss) and the following general formula (10)

[0095]

Embedded image

(Where f ₁ represents a number from 4 to 500)
Demnum S-20 (weight average molecular weight 25.0
00), S-65 (4,500), S-100
(5,600) and S-200 (8,400)
Commercially available products (such as those manufactured by Daikin Industries, Ltd.) can be used.

Examples of the fluorine-modified silicone include those having at least one of structural units represented by the following general formulas (11) to (14) and a structural unit represented by the following general formula (15). Can be mentioned.

[0098]

Embedded image

[In the formula, Rf and Rf 'may be the same or different and each is a linear or branched perfluoroalkyl group having 1 to 20 carbon atoms or the following formula: H (CF ₂ ) _g1- (g
₁ represents an integer of ₁ to 20), wherein R ¹⁶ , R ¹⁹ and R ²⁰ may be the same or different and each have a carbon number of 1 to 20; A chain or branched aliphatic hydrocarbon group or an alicyclic or aromatic hydrocarbon group having 5 to 10 carbon atoms; R ¹⁷ is a hydrogen atom, a linear or branched aliphatic chain having 1 to 20 carbon atoms; A hydrocarbon group, an alicyclic or aromatic hydrocarbon group having 5 to 10 carbon atoms, a perfluoroalkyl group having 1 to 20 carbon atoms or the following formula: H (CF ₂ ) _g1- (g ₁ is an integer of ₁ to 20) Indicates)
An ω-H-perfluoroalkyl group represented by the formula:
¹⁸ represents a divalent hydrocarbon group having 2 to 6 carbon atoms; X ² and Y ² is a single bond, -CO- or a divalent hydrocarbon group having 1 to 6 carbon atoms; i ₁ is indicates the number of 2 to 16, j ₁ and k ₁ each represents the number of 1 to 16, h ₁ is 20
Indicates the number of 0, w ₁ represents a number of 0~20, v ₁ is 0
Show the number of 200]

In the structural units represented by the general formulas (11) to (15), as the perfluoroalkyl group represented by Rf and Rf ′, any of a straight-chain or a branched chain can be used. , CF _3- , C ₂ F _5- , C ₄ F
_{9 -, C 6 F 13 -} , C 8 F 17 -, C 10 F 21 -, H (CF 2)
_{2 -, H (CF 2)} 4 -, H (CF 2) 6 -, H (CF 2) 8
—, (C ₃ F ₇ ) C (CF ₃ ) ₂ — and the like. Further, _{g in} H (CF ₂ ) _g − is 6 to 2
An integer of 0 is preferred. Examples of the hydrocarbon groups represented by R ¹⁶ , R ¹⁹ and R ²⁰ include straight-chain groups such as methyl, ethyl, propyl, butyl, pentyl, hexyl, heptyl, octyl, nonyl, and decyl groups. Branched alkyl group such as isopropyl group, s-butyl group, t-butyl group, neopentyl group, 1-ethylpropyl group, and 2-ethylhexyl group; cyclic alkyl group such as cyclopentyl group and cyclohexyl group; phenylnaphthyl And an aromatic hydrocarbon group such as a group. As the divalent hydrocarbon group represented by R ^38, preferably is a linear or branched alkylene group having 2 to 4 carbon atoms, particularly an ethylene group, a propylene group are preferable.

As the fluorine-modified silicone having such a structural unit, for example, the following general formula (16)

[0102]

Embedded image

[In the formula, at least one of Z ² and Z ³ represents a structural unit selected from the general formulas (11) to (14), the remainder represents a single bond, and v ₁ , R ¹⁹ and R ²⁰ represent the same as above. Having the same meaning as described above) or the following general formula (1
7)

[0104]

Embedded image

[Wherein, Z^FourAre represented by the general formulas (11) to (1)
5) a structural unit selected from^{twenty one}Is carbon number 1-2
0 linear or branched aliphatic hydrocarbon group or carbon number
Represents 5 to 10 alicyclic or aromatic hydrocarbon groups,
p₁Represents a number from 0 to 200; ₁, R¹⁹And R²⁰Is before
The meaning is the same as
Wear.

The structural units represented by the general formulas (11) to (15) and the group in each formula in the fluorine-modified silicone represented by the general formulas (16) and (17) are used to prevent makeup loss and to improve usability. In consideration of the following, the following are preferable. Rf and Rf 'each represent a linear or branched perfluoroalkyl group having 6 to 20 carbon atoms or the following formula;
_{(CF 2) q1 - (q} 1 is an integer of 6-20) preferably omega-H- perfluoroalkyl group represented by.
R ¹⁶ , R ¹⁹ and R ²⁰ may be the same or different and are preferably a straight-chain or branched-chain aliphatic hydrocarbon group having 1 to 4 carbon atoms. R ¹⁷ is a hydrogen atom, a carbon number of 6 to 2;
A perfluoroalkyl group of 0 or the following formula: H (CF ₂ ) _q1
- ω-H- (q ₁ is an integer of 6-20) represented by
Perfluoroalkyl groups are preferred. R ¹⁸ is preferably a divalent hydrocarbon group having 2 to 4 carbon atoms. X ² and Y
² is preferably a single bond, -CO- or a divalent hydrocarbon group having 1 to 4 carbon atoms, i ₁ is preferably a number of 2 to 10, especially 2 to 5, and j ₁ and k ₁ are each 2 -10, especially 1
And the number h1 is preferably ₁ to 100, particularly 1 to 10
Preferably the number of, w ₁ is 0 to 20, particularly preferably the number of 0 to 5, v ₁ is 0 to 100, in particular the number of 0 preferred. The arrangement of the structural units of the fluorine-modified silicone represented by the general formula (17) may be alternate, block, or random.

Further, as a preferred example of the fluorine-modified silicone, a polymerization degree of from 2 to 200 described in JP-A-5-247214, having structural units represented by the general formulas (12) and (15), is preferable. Of fluorine-modified silicone,
Japanese Unexamined Patent Application Publication No. Hei 6 (1994) -6 having a structural unit represented by formula (13)
No. 184312, a fluorine-modified silicone having a polymerization degree of 2 to 200, a commercially available FSL manufactured by Asahi Glass Co., Ltd.
-300, Shin-Etsu Chemical's X-22-819, X-
22-820, X-22-821, X-22-822 and FL-100, FS-1265 manufactured by Dow Corning Toray Silicone Co., Ltd., and the like.

When these fluorine-based oils are blended, it is preferable to blend them in an amount of from 2 to 98% by weight, especially from 5 to 60% by weight in the whole composition, since the feeling in use becomes good.

The ultraviolet protective agent is not particularly limited, and any of commonly used ultraviolet scattering agents, oil-soluble ultraviolet absorbers, and water-soluble ultraviolet absorbers can be suitably used. Among these, as the ultraviolet scattering agent, for example, titanium oxide and fine particle titanium oxide (Japanese Patent Application Laid-Open No. 57-67)
681), zinc oxide, fine zinc white (Japanese Patent Laid-Open No. Sho 62-62).
228006), flaky zinc oxide (Japanese Unexamined Patent Publication No.
No. 75921), iron oxide, fine-particle iron oxide, cerium oxide, zirconium oxide and the like. These may be those which have been surface-treated with silicone, metal soap, N-acylglutamic acid, perfluoroalkyl phosphate or the like. Good. Their shape, size and form are not particularly limited, and they may be used in the form of a sol or the like.

As the oil-soluble ultraviolet absorber, benzoic acid-based ultraviolet absorbers include para-aminobenzoic acid (hereinafter referred to as PA).
BA), glyceryl PABA, ethyl dihydroxypropyl PABA, N-ethoxylate PABA ethyl ester, N-dimethyl PABA ethyl ester, N
-Dimethyl PABA butyl ester, N-dimethyl PA
BA amyl ester, octyl dimethyl PABA and the like;
Anthranilic acid-based homomenthyl-N
-Acetylanthranilate and the like; salicylic acid-based ones, such as amyl salicylate, menthyl salicylate,
Homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate, etc .; cinnamic acid-based octyl cinnamate, ethyl-4-isopropyl cinnamate, Ethyl-2,4-diisopropylcinnamate, methyl-2,4-diisopropylcinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-
Methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate, 2-ethoxyethyl-p-methoxycinnamate, cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α -Cyano-β-phenylcinnamate, glycerylmono-2-ethylhexanoyldiparamethoxycinnamate and the like; 2,4-dihydroxybenzophenone as a benzophenone type;
2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dihydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenylbenzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone and the like But also: 3- (4'-methylbenzylidene) -dl-camphor, 3-benzylidene-dl-camphor, urocanic acid ethyl ester,
-Phenyl-5-methylbenzoxazole, 2,2'-
Hydroxy-5-methylphenylbenzotriazole,
2- (2'-hydroxy-5-t-octylphenyl)
Benzotriazole, dibenzalazine, dianisoylmethane, 4-methoxy-4'-t-butyldibenzoylmethane, 5- (3,3-dimethyl-2-norbonylidene)
-3-pentan-2-one, a benzene bis-1,3-diketone derivative described in JP-A-2-212579,
And benzoylpinacone derivatives described in JP-A-3-220153.

Examples of the water-soluble ultraviolet absorber include diethanolamine p-methoxycinnamate, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, tetrahydroxybenzophenone, methylherperidine, and 3-hydroxy-4-methoxycinnamate Sodium acid, sodium ferulate, urocanic acid and the like, and extracts of animals and plants such as yarrow, aloe, below mallow, burdock, salvia and the like, which have an ultraviolet absorbing effect, are exemplified.

Among these ultraviolet protective agents, zinc oxide, titanium oxide, fine titanium oxide, fine zinc white, flaky zinc oxide, fine iron oxide, octyldimethyl PAB
A, 2-ethylhexyl-p-methoxycinnamate,
4-methoxy-4'-t-butyldibenzoylmethane,
1- (3,4-Dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione is preferred.

When these ultraviolet protective agents are blended, 0.1 to 40% by weight, especially 0.1 to 30% by weight in the total composition.
%, More preferably 1 to 20%.

Examples of the powder include extenders such as mica, talc, sericite, kaolin, nylon powder and polymethylsilsesquioxane; inorganic pigments such as pearl;
Organic pigments such as Red No. 202, Red No. 226, Yellow No. 4, and aluminum lake are exemplified. These powders are subjected to a surface treatment such as a silicon treatment, a metal soap treatment, an amino acid treatment, a fatty acid treatment, an alkyl phosphate ester treatment, an N-acylglutamic acid treatment, a fluorine treatment by a perfluoroalkyl phosphate ester treatment, or the like. May be used.

When these powders are blended, they are preferably blended in an amount of 0.001 to 50% by weight, particularly 0.005 to 30% by weight, based on the total composition.

Examples of the oil gelling agent include dextrin fatty acid esters such as dextrin palmitate and dextrin stearate. When these oil gelling agents are blended, 0.001 to 20
% By weight, particularly preferably 0.01 to 5% by weight.

Examples of the film-forming agent include vinyl polymers such as polyvinyl alcohol, polyvinylpyrrolidone, and sodium polyacrylate; emulsions of chitosampleran emulsion and alkyl acrylate copolymer emulsion; soluble collagen, hydrolyzed elastin;
Polypeptides such as silk extract; molecular weight 20,000
To 4,000,000 polyethylene glycol and the like. When these film-forming agents are blended, 0.01 to 30% by weight, particularly 0.05 to 20% by weight in the total composition
It is preferable to mix them.

Further, sebum secretion inhibitors are those that prevent pigmentation around the pores, rough skin, acne, etc. due to excess sebum, and are described, for example, in “Fragrance Journal No. 10 (1994)”. Anti-androgenic agents, herbal extracts, astringents, and other components generally used as sebum secretion inhibitors can be used.

[0119] Specifically, as antiandrogens,
Examples include oxendrone, 17-α-methyl-β-nortestosterone, chromadinone acetate, cyproterone acetate, spironolactone, hydroxyflutamide, estradiol, ethinylestradiol, and the like.

The crude drug extracts include, for example, walnut leaves,
Oregon, sage, hop, rosemary, hypericum, peppermint, chamomile, pheasant bird, yellow ream, yellow bamboo, yellow rye, heavy medicine, Chen skin, carrot, peonies, toshishi, propolis,
Extracts such as taxia, tannin, hamamelis, button, birch tar, royal jelly, and extract of Kobo are mentioned.

Examples of the astringent include zinc sulfocarbonate, zinc oxide, aluminum hydroxychloride, allantoindihydroxyaluminum and the like.
In addition, vitamin B ₆ , 13-cis-retinoic acid, vitamin E, glycyrrhetinic acid, salicylic acid, nicotinic acid, calcium pantothenate, dipotassium azelate, 10-hydroxyundecanoic acid, 12-hydroxystearic acid, etc. are also sebum secretion inhibitors. Can be used.

Among these, estradiol, zinc sulfocarbonate, zinc oxide, royal jelly, 10-hydroxyundecanoic acid and 12-hydroxystearic acid are particularly preferred.

When these sebum secretion inhibitors are blended, 0.01 to 10% by weight, especially 0.1 to 5% by weight in the total composition.
% By weight (in the case of a crude drug extract, as dry solids).

Examples of the softener include, but are not particularly limited to, α-hydroxy-isobutyric acid, α-hydroxy-isocaproic acid, α-hydroxy-n-caproic acid, α-hydroxy-isocaprylic acid, and α-hydroxy-isocaprylic acid. Hydroxy-n-caprylic acid, α-hydroxy-n-capric acid,
Lactic acid, α-hydroxystearic acid, citric acid, α-hydroxy acids such as glycolic acid, lysine, arginine,
In addition to basic amino acids such as histidine, ornithine and canavanine, amines such as ε-aminocaproic acid, urea and 2-hydroxyguanidine-2- (2-hydroxyethoxy) ethylguanidine, JP-A-62-99315, Peptides described in JP-A-2-178207 and trimethylglycine described in JP-A-6-293625 are exemplified. When these softeners are blended, it is preferable to blend 0.05 to 10% by weight, especially 0.2 to 5% by weight in the whole composition.

Examples of the pH adjuster include metal hydroxides such as sodium hydroxide, potassium hydroxide and lithium hydroxide, triethanolamine, isopropanolamine, and the like.
Organic acids such as diisopropanolamine, urea, ε-aminocaproic acid, sodium pyrrolidonecarboxylate, sodium hydrogenphosphate, sodium citrate, citric acid, lactic acid, succinic acid, tartaric acid, etc .; betaines such as glycine betaine and lysine betaine; No. The cosmetic of the present invention can be prepared by using these pH adjusters and the like to adjust the pH to 2 to 11, particularly to the pH of 3.
It is preferable to set the region to 10 to 10.

Further, other components include, for example, inorganic salts such as magnesium sulfate, potassium sulfate, sodium sulfate, magnesium chloride and sodium chloride; preservatives such as paraben, dehydroacetic acid and its salts; edetic acid and its salts; Sequestering agents such as acids and salts thereof; 6-
Hydroxyhexanoic acid, 8-hydroxyundecanoic acid,
Hydroxy acids such as 9-hydroxyundecanoic acid, 10-hydroxyundecanoic acid and ethyl 11-hydroxyundecanoate and salts thereof; pigments, medicinal ingredients, fragrances and the like.

In the present invention, a suitable amount of a polymer compound can be blended, and examples thereof include a polysaccharide and a water-soluble thickener. As the polysaccharide, an acidic polysaccharide is preferable.For example, according to the method described in JP-A-64-10997, callus derived from a plant belonging to the genus Polyanthes can be cultured and collected from the resulting culture. it can.
Preferred examples of plants belonging to the genus Polyanthes include tuberose (Polianthestuberosa L.). As the acidic polysaccharide, it is particularly preferable to use a modified heteropolysaccharide derived from callus of tuberose.

As a method for collecting the acidic polysaccharide, for example, in the case of tuberose, it can be performed according to the following tissue culture method. That is, ^10-5 M of auxin and 10 ^-6 M of cytokinin are added as plant hormones to a base medium of Linsamaier-skool as explants of a part of tuberose flowers and the like, and 3% sucrose is further added as a carbon source. After the callus is induced using the added medium, subculture is performed, followed by shaking culture using a liquid medium containing the same components as the above callus culture medium.
Thereafter, the cells are removed from the culture solution by centrifugation or filtration, and the culture solution is concentrated using a rotary evaporator or the like, and the concentrated solution is precipitated by adding a solvent such as ethanol or acetone, and the precipitate is freeze-dried. Thus, the acidic polysaccharide can be separated and obtained.

The acidic polysaccharide thus obtained is preferably contained in the entire composition in an amount of 0.0001 to 30% by weight, particularly 0.001 to 20% by weight, more preferably 0.01 to 15% by weight.
When blended by weight, a high moisturizing effect, an effect of preventing and improving rough skin, and an effect of preventing and improving spots and freckles are obtained, and are also preferable in terms of feeling of use and stability.

Examples of the water-soluble thickener include acrylic acid polymers and water-soluble polymers. Among these, the acrylic acid-based polymer forms a gel by neutralization with an alkaline agent. Accordingly, the acrylic acid polymer is not particularly limited as long as it forms a gel by neutralizing with an alkali agent, and a polymer generally called a water-soluble alkali thickening polymer is used. Such acrylic acid-based polymers include:
For example, B. F. Goodrich (BFGoodrich Compan
y) Carbopol 90 commercially available from
7, 910, 934, 934-P, 940, 941, 9
54, 980, 981, 1342, ETD2020, E
TD2050, 1382, 2984, 5984, etc .; Pemulen TR-1, TR-2, etc .;
o Hypan commercially available from Chemicals Inc.
m) SA-100H, SR-150H, SS-201,
AQUPEC HV-501, HV-504, HV-5 commercially available from Sumitomo Seika Co., Ltd. such as QT-100
And Sepigel (SEPIGEL) 305, 501 commercially available from Seppic. Inc. Of these, particularly preferred acrylic acid polymers include Carbopol 941, 981, 940, 98
0, 1342, 1382; Pemran TR-1, TR-
2. Sepigel 305.

These acrylic polymers can be used alone or in combination of two or more. The amount of the acrylic polymer depends on the type of the polymer and may be determined as appropriate.
It is preferable to mix 0.1 to 20% by weight in the whole composition,
In particular, it is preferable to add 0.1 to 10% by weight, more preferably 0.15 to 5% by weight, because it is excellent in moisturizing effect, feeling in use and stability.

Examples of the alkaline agent for neutralizing and gelling the acrylic polymer include inorganic bases such as sodium hydroxide, potassium hydroxide and ammonium hydroxide and organic acids such as triethanolamine and L-arginine. Salts. These alkaline agents are used in an amount of 0.1 to 3 parts by weight, especially 0.1 to 3 parts by weight, based on 1 part by weight of the acrylic acid polymer.
It is preferable to use 5 to 2 parts by weight.

The water-soluble polymer is not particularly limited as long as it is used in ordinary cosmetics and the like. Examples thereof include guar gum, quince seed, carrageenan, locust bean gum, gum arabic, tragacanth, pectin, mannan, and the like. Starch, sodium alginate, sodium hyaluronate, xanthan gum, pullulan dextran, curdlan, collagen, keratin, casein, albumin, gelatin, chondroitin sulfate, chitin, cationized cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, Hydroxypropyltrimethylammonium chloride ether, carboxymethylcellulose, dextran sulfate, carboxymethyl Emissions, soluble starch, carboxymethyl starch, propylene glycol alginate, polyvinyl alcohol, polyvinyl pyrrolidone, sodium polyacrylate, polyvinyl methyl ether,
Polyethylene glycol and the like. Among these, xanthan gum, sodium hyaluronate, hydroxyethyl cellulose and the like are particularly preferred.

These water-soluble polymers can be used alone or in combination of two or more.
It is preferable to mix 5.0% by weight, especially 0.05 to
It is preferable to add 3.0% by weight, more preferably 0.05 to 0.3% by weight, because it is excellent in moisturizing effect, feeling in use and stability.

The cosmetic of the present invention can be produced according to a conventional method. Further, the cosmetic of the present invention is not limited to general skin cosmetics, but encompasses quasi-drugs, topical medicines, etc., and the dosage form may be arbitrarily selected according to the purpose. Cream, ointment, emulsion, lotion, solution, gel, pack, powder, stick, etc.

The cosmetics of the present invention may be in various forms, for example, water / oil type emulsified cosmetics, oil / water type emulsified cosmetics, creams, cosmetic emulsions, lotions, oily cosmetics, packs, lipsticks,
It can be used as a cosmetic such as a foundation, a skin cleanser, a hair tonic, a hair styling agent, a hair restorer, a hair restorer and the like.

[0137]

The cosmetic composition of the present invention provides a synergistic moisturizing effect, a preventive and ameliorating effect on skin roughness, and a skin patch by using an ether compound of the component (A) in combination with the pharmaceutically active ingredient (B).・ Prevention / improvement effect of weakening of elasticity / dullness of complexion,
Prevention and improvement of wrinkle formation and prevention of spots and freckles
The improvement effect is enhanced, and the feeling and stability are further improved. In particular, when the cosmetic of the present invention is an emulsified cosmetic, the emulsion stability is extremely good.

[0138]

EXAMPLES The present invention will be described below in more detail with reference to examples, but the present invention is not limited to these examples. still,
Unless otherwise specified,% in the examples is based on weight, and the amount of the plant extract is represented by a value converted into a dry solid content.

Examples 1 to 6 and Comparative Examples 1 and 2 Moisturizing cosmetics were prepared in the proportions shown in Table 1.

[0140]

[Table 1]

Test Example 1 100 mg / cm ^{2 of} the moisturizing cosmetic prepared as described above was applied to the skin surface of a washed Yucatan micropig and left in a thermo-hygrostat (37 ° C., 100% humidity). After 18 hours, the unpermeated components remaining on the skin surface were removed, and the permeated components were extracted and collected, and expressed by the percutaneous absorption (μg / cm ² ) of the spiroether compound by HPLC. Table 1 shows the results.

From Table 1, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of ceramides was improved.

Examples 7 to 12 and Comparative Examples 3 and 4 Moisturizing cosmetics were prepared in the proportions shown in Table 2.

[0144]

[Table 2]

Test Example 2 With respect to the moisturizing cosmetic obtained above, the penetration amount was measured using a ¹⁴ C-labeled isotope of glycine. That is,
Glycine labeled with ¹⁴ C was dissolved in each moisturizing cosmetic so that the radioactivity was 100,000 dpm. this,
The solution was applied to Yucatan micro pig skin so as to have a concentration of 100 μl / cm ² , and was percutaneously absorbed at 37 ° C./RH for 18 hours. Thereafter, the labeling glycine permeated into the stratum corneum and epidermis was measured using a liquid scintillation counter. Table 2 shows the results.

From Table 2, it was confirmed that the percutaneous absorbability of amino acids was improved when the ether compound (A) represented by the general formula (1) was blended.

Examples 13 to 18 and Comparative Examples 5 and 6 Whitening cosmetics were prepared in the proportions shown in Table 3.

[0148]

[Table 3]

Test Example 3 The penetration amount of the whitening cosmetic prepared above was measured in the same manner as in Test Example 2, except that a ¹⁴ C-labeled isotope of L-ascorbic acid was used. Table 3 shows the results.

From Table 3, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of the whitening agent was improved.

Examples 19 to 24 and Comparative Examples 7 and 8 Whitening cosmetics were prepared in the proportions shown in Table 4.

[0152]

[Table 4]

Test Example 4 A test was conducted in the same manner as in Test Example 1 using the whitening cosmetic prepared as described above. Table 4 shows the results.

From Table 4, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of the plant extract was improved.

Examples 25 to 30 and Comparative Examples 9 and 10 Anti-inflammatory cosmetics were prepared in the proportions shown in Table 5.

[0156]

[Table 5]

Test Example 5 A test was conducted in the same manner as in Test Example 1 using the anti-inflammatory cosmetic prepared as described above. Table 5 shows the results.

From Table 5, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of the anti-inflammatory agent was improved.

Examples 31 to 36 and Comparative Examples 11 and 12 Moisturizing cosmetics were prepared in the proportions shown in Table 6.

[0160]

[Table 6]

Test Example 6 A test was conducted in the same manner as in Test Example 1 using the moisturizing cosmetic prepared as described above. Table 5 shows the results.

From Table 6, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of sterols was improved.

Examples 37 to 46 and Comparative Examples 13 and 14 Blood circulation promoting effects (dullness improving effects) at the compounding ratios shown in Table 7
A cosmetic product having a certain quality was prepared.

[0164]

[Table 7]

Test Example 7 A test was conducted in the same manner as in Test Example 1 using the cosmetic composition having the above-mentioned effect of promoting blood circulation (improvement of dullness).
Table 7 shows the results.

From Table 7, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of the blood circulation promoter was improved.

Examples 47 to 52 and Comparative Examples 15 and 16 Moisturizing cosmetics were prepared in the proportions shown in Table 8.

[0168]

[Table 8]

Test Example 8 The moisturizing cosmetic prepared above was treated with ¹⁴ C of glycerin.
The amount of permeation was measured in the same manner as in Test Example 2 except that the labeled isotope was used. Table 8 shows the results.

From Table 8, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of alcohols was improved.

Examples 53 to 58 and Comparative Examples 17 and 18 Wrinkle improving cosmetics were prepared at the mixing ratios shown in Table 9.

[0172]

[Table 9]

Test Example 9 A test was conducted in the same manner as in Test Example 1 using the wrinkle improving cosmetic prepared as described above. Table 9 shows the results.

From Table 9, it was confirmed that when the ether compound (A) represented by the general formula (1) was blended, the transdermal absorbability of the antioxidant and the singlet oxygen scavenger was improved.

────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 7/00 A61K 7/00 X 7/48 7/48 (72) Inventor Yamazaki Saki Seiji 2 Sumika-ku, Tokyo -1-3 Kao Corporation Research Laboratory

Claims (12)

[Claims] (A) R ¹ -O- (XO) _n -R ² (1) wherein R ¹ and R ² are the same or different and each have 1 carbon atom ~
X represents a linear, branched or cyclic alkyl group of 24, X represents an alkylene group having 1 to 12 carbon atoms, and n represents 0 or 1. A total of 10 to 32 carbon atoms of R ¹ , R ² and X), and (B) one or more skin medicinal ingredients. Fees. 2. The skin medicinal ingredient (B) comprises ceramides, ceramide-like structural substances, humectants, amino acids, plant extracts, whitening agents, anti-inflammatory agents, singlet oxygen scavengers, antioxidants,
The cosmetic according to claim 1, wherein the cosmetic is at least one selected from alcohols, sterols, and blood circulation promoters. 3. The skin medicinal component (B) is represented by the following general formulas (2) to (7): [Wherein, R ³ and R ⁴ are the same or different and each represent a straight-chain or branched-chain saturated or unsaturated hydrocarbon group having 8 to 26 carbon atoms which may be substituted with a hydroxyl group]. [Wherein, R ⁵ represents a linear or branched saturated or unsaturated hydrocarbon group having 10 to 26 carbon atoms, and R ⁶ represents 9 to 2 carbon atoms.
5 represents a linear or branched saturated or unsaturated hydrocarbon group, Y ¹ and Z ¹ represent a hydrogen atom or a hydroxyl group, and a represents 0
Or 1 represents a number, c represents an integer of 0 to 4, b and d
Represents an integer of 0 to 3]. Wherein R ⁷ and R ⁸ are the same or different and have 1 to 1 carbon atoms.
A linear or branched saturated or unsaturated hydrocarbon group which may be hydroxylated, and R ⁹ has 1 carbon atom
And R ⁶ represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-dihydroxypropyloxy group. However, when R ⁹ is a single bond, R ¹⁰ is a hydrogen atom. [Chemical formula 5] [Wherein, R ^7a represents a hydrocarbon group which may be hydroxylated having 4 to 40 carbon atoms, R ^9a represents a linear or branched alkylene group having 3 to 6 carbon atoms, and R ^10a represents a carbon atom. Number 1
And 12 to 12 linear or branched alkoxy groups. [Formula 6] Wherein R ⁷ , R ⁸ , R ^9a and R ^10a have the same meaning as described above. [Formula 7] Wherein R ⁷ , R ⁸ and R ⁹ have the same meaning as described above;
R ^10b represents a hydrogen atom, a linear or branched alkoxy group having 1 to 12 carbon atoms or a 2,3-epoxypropyloxy group. However, when R ⁹ is a single bond, R ^10b is a hydrogen atom. The cosmetic according to claim 1 or 2, which is selected from ceramides and ceramide-like substances represented by the formula: 4. The cosmetic according to claim 1, wherein the skin medicinal component (B) is one or more selected from amino acids and salts thereof. 5. The skin active ingredient (B) is one or more selected from L-ascorbic acid and its derivatives, hydroquinone derivatives, kojic acid and its derivatives, and placental extracts. Cosmetics. 6. The cosmetic according to claim 1, wherein the skin medicinal component (B) is one or more selected from plant extracts. 7. The plant extract may include chamomile, cha, cucumber, butterflies, liquorice, loquat, spruce, ginseng, peonies, hawthorn, barley winter, ginger, matsukasa, mulberry bark, magnolia, linchenko, The cosmetic according to claim 2 or 6, wherein the cosmetic is one or more selected from extracts of Asenyaku, Ogon, Aloe, Altea, Spiraea, Dutch mustard, kina, comfrey, rosemary and funnel. 8. The plant extract, wherein the plant extract is selected from horsetail, gentian, hamamelis, button, cornflower, catalpa, asunaro, holtsou, cypress, and pheasant
The cosmetic according to claim 2, wherein the cosmetic is a kind or two or more kinds. 9. The cosmetic according to claim 1, wherein the skin medicinal component (B) is one or more selected from carotene, tocopherol, tannic acid, epicatechin gallate, and epicarocatechin gallate. 10. The skin medicinal component (B) is composed of tocopherol nicotinate, nicotinamide, tocopherol acetate, assembly extract, hypericum extract, ginkgo extract, arnica extract, kina extract, hamamelis extract, calendula extract, malonier extract, emmeisou The cosmetic according to claim 1, wherein the cosmetic is one or more selected from an extract, a salvia extract, a Hamabofu extract, a salamander extract, a rice germ oil, a borage extract, a ginger tincture, and a clove extract. 11. The cosmetic according to claim 1, wherein the ether compound (A) is a compound wherein n in the general formula (1) represents 0. 12. The cosmetic according to claim 11, wherein the ether compound (A) is a compound in which R ¹ and / or R ^{2 in} the general formula (1) represent an alkyl group branched at two or more places.