JPH11116458A - Composition of preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition of preparation for external use containing aloe, capable of enhancing modest skin curing effect of aloe and reducing mixing amount of aloe, and effective to symptoms, such as curing of wound or burning of the skin, and making quiescent sunburn. SOLUTION: This composition of preparation for external use for skin contains (1) aloe and/or an extract of aloe and (2) at least one kind selected from extracts of marine algae belonging to the family Ulvaceae, Gracilariaceae, Gelidiaceae, Solieriaceae, Laminariaceae, Alariaceae, Sargassaceae, Fucaceaceae, Gloiopeltidaceae, Monostromataceae, Codiaceae, Bangiaceae, Gigartinaceae, Bonnemaisoniaceae, Hypneaceae, Chordariaceae, Nemacystaceae, Durvilleaceae, Lessoniaceae and Rhodymeniaceae, as essential components.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION The present invention relates to an aloe-based skin wound and therapeutic effect by applying to skin.
A skin external preparation composition capable of recovering the barrier function of the skin stratum corneum damaged by sunburn etc. at an early stage and returning it to a normal state by a synergistic effect of the skin moisturizing property improving sustained effect of the seaweed extract About. The skin external preparation composition of the present invention is applied to various external preparations such as skin patches such as cataplasms, creams, emulsions, lotions, gels, ointments, and aerosols.

[0002]

2. Description of the Related Art Aloe is a medicinal liquid obtained from fresh leaves, and the liquid obtained by heating to dryness is used internally as a bitter tonic, stomachic and laxative. In addition, aloe can cause skin damage, such as burns, cracks, irritations, acne,
It is known to be effective for sunburn. Conventionally, proposals have been made in which the effectiveness of aloe on the skin is applied to a skin external preparation. JP-A-61-129117 discloses a poultice containing aloe powder or aloe liquid. Since the poultice is in the form of a poultice compared to the conventional aloe ointment, it is said that a particularly excellent anti-inflammatory effect can be obtained. Japanese Patent Publication No. 3-31172 discloses an external treatment member formed by mixing aloe or an aloe extract with a hydrophilic hydrogel base and molding it into a sheet.

[0003]

The skin treatment effect of aloe itself is mild, and a considerable amount of aloe extract is used for skin damage, for example, for treatment of skin wounds, burns, soothing sunburn, etc. It had to be combined or treated with the pharmacological effects of the separately combined drugs. If the amount of aloe or aloe extract is increased in anticipation of the skin treatment effect of aloe, the physical properties of the composition may change, or the composition may have a problem in flavor or color. In addition, increasing the amount of aloe increases the product cost.

[0004] The present invention has been made in view of the above circumstances, to enhance the mild skin treatment effect of aloe, reduce the amount of aloe, and to treat skin wounds and burns, soothing sunburn, etc. An object of the present invention is to provide an aloe-containing external preparation composition effective for symptoms.

[0005]

Means for Solving the Problems The present inventors have found that a skin external preparation composition obtained by blending an extract of a certain seaweed such as Deraviaceae with aloe has an excellent skin treatment effect. And completed the present invention.

That is, the present invention relates to an aloe and / or an aloe extract, and a family of Ulvaaceae and Ogonori (Gr.
acilariaceae), Tengulidae (Gelidiaceae), Myrinaceae (Solieriaceae), Laminariaceae (Laminariaceae), Ainuyukameidae (Alariaceae), Hondawaraceae (Sargassa)
ceae), Physaceae (Fucaceae), Funori (Gloiopel)
tidaceae), Coleaceae (Monostromataceae), Myrridae (Codiaceae), Bossaceae (Bangiaceae), Gibberinae (Gigartinaceae), Berlinaceae (Bonnemaisonia)
ceae), Ibaranori family (Hypneaceae), Pinaceae family (Chordariaceae), Dermataceae family (Nemacystaceae), Durvilleaceae family (Durvilleaceae), Lessonian family (Lessoniac family)
eae) and an extract of seaweed belonging to the family Rhodymeniaceae, which is an external preparation for skin containing as an essential component at least one selected from the group. The skin external preparation composition of the present invention is suitable as a hydrous cataplasm.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The external preparation composition for skin according to the present invention comprises aloe and / or aloe extract; Ulvaaceae, Ogonoriaceae, Tengusaaceae, Mirinaceae, Laminariaceae, Ainuwakameidae, Hondawaraceae, Hibamataceae, Effective for at least one species selected from seaweed extracts belonging to the family Funugiidae, the family Exercaceae, the miraceae, the oxaceae, the cynoaceae, the scrophulariaceae, the balticaceae, the scrophulariaceae, the makaceae, the derviliaceae, the lessoniaceae, and the darusaceae It is characterized by being blended as a component. By combining and combining aloe and seaweed extract in this way, the therapeutic effect of aloe on mild wounds and burns, the sustained effect of improving the moisturizing properties of seaweed extract and the early recovery of the barrier function of the skin stratum corneum The effect works synergistically to reduce inflammation of the skin, restore moisturizing properties and provide a firmer freshness when used on skin damaged by sunburn, burns, wounds, etc. This "moisture retention sustaining effect" means that when applied to the skin, the moisturizing property of the part is increased, and when the patch is used, the high moisturizing state is maintained for a long time after peeling off the skin, preferably for 20 minutes. That is to maintain. In addition, the `` early recovery effect of the barrier function of the skin stratum corneum '' means that it is damaged by cracks, cracks, abrasions, sunburns, etc., the original moisturizing function is reduced, and by applying it to the inflamed skin, It refers to the effect of quickly restoring moisturizing properties, soothing inflammation and recovering normal skin early, preferably within 24 hours. The barrier function of the skin stratum corneum and TWL (transdermal water loss) as an index thereof are described in detail in “New Cosmetic Science”, edited by Takeo Mitsui and Nanzando.

As the aloe and / or aloe extract used in the present invention, it is preferable to use cape aloe, socotra aloe and the like described in the Pharmacopoeia, but other aloe genus, for example, natal aloe and samba aloe may be used. . When aloe is included in the composition, aloe sap,
It can be added as aloe powder or aloe extract. When producing an aloe extract, the raw material aloe may be in an undried state, but it is preferable from the viewpoint of extraction efficiency that the raw material aloe is dried by a method such as air drying or freeze drying and then subjected to extraction. The method for extracting the aloe extract is not limited, and a normal extraction method is employed, and the extraction is performed using water, a sodium chloride solution, a hydrophilic organic solvent, a hydrated hydrophilic organic solvent, another organic solvent, or the like.

Examples of the hydrophilic organic solvent include lower alcohols such as methanol, ethanol and isopropanol, glycols such as propylene glycol and 1,3-butylene glycol, glycerin, acetone, methyl ethyl ketone, acetonitrile, dimethyl sulfoxide, dimethylformamide and the like. And the like. In particular, it is preferable to perform extraction using water or a mixture of water and a lower alcohol such as methanol, ethanol, or isopropanol. In this case, the ratio of water to lower alcohol is such that lower alcohol / water is 0/100 to 70/3.
It is preferably 0 (V / V: volume ratio), more preferably 0/100 to 40/60. The extract may be used as it is, or may be used as a dilute solution or a concentrated extract, or may be prepared as a dry powder by freeze-drying or the like, or may be prepared in a paste form. Further, a commercially available aloe extract can be used, and for example, aloe vera liquid manufactured by Ichimaru Falcos Co., Ltd. is preferably used.

The amount of aloe and / or aloe extract can be appropriately selected according to the dosage form and purpose of use of the composition for external use on the skin.
When a commercially available aloe extract containing 00 g of the extract is used, 0.001 to 20% by weight (hereinafter, simply referred to as%),
Preferably, it is 0.01 to 10%. As described above, in the present invention, the use of aloe and a seaweed extract can provide an excellent skin treatment effect. Can be kept low.

[0011] Ulva (Ulvaceae) used in the present invention
As the seaweed belonging to the genus Aosa, genus Ulva, Enteromorpha, and genus Ulvaria are used, and the genus Aosa and Aonori are preferable. Examples of the seaweed belonging to the family Ogonoriaceae (Gracilariaceae) used in the present invention include the genus Ogonori (Gracilaria), the genus Gracilariapsis (Gracilariopsis), the genus Namiiwatake (Tylotus), the genus Genus serrata (Gelidiopsis), and the like. Genus. The seaweeds belonging to the family Apiaceae (Gelidiaceae) used in the present invention include genus Maxi (Gelidium), nettle (Beckerella), genus Pterocladia, and genus Acanthopelti.
s) and the like, and preferably belong to the genus Maxa. The seaweeds belonging to the family Solieriaceae used in the present invention include those of the genus Giraffe (Eucheuma),
otheca), Myrin (Solieria), Ezoname (Turn)
erella) and the like, and preferably belong to the genus Kirinsai and the genus Tosanori. Laminaria family (Lamina) used in the present invention
seaweed belonging to the genus Laminari (Laminari)
a), the genus Troloquim (Kjellmaniella),
klonia), Alame (Eisenia), Antokume (Ecklo)
niopsis), Agarum, and Costari
a), the genus Arthrothamnus, the genus Hedophyllum, etc., are preferably used, and preferably the genus Kombu, the genus Trolocomb, the genus Caladium, the genus Alame, and the genus Antokume. The Ainu sea turtle family (Alaria) used in the present invention
ceae) include seaweed genus (Undaria) and Ainuwakame (Alaria). The seaweeds belonging to the family Sargassaceae used in the present invention include the genus Hizikia and the genus Sargassu.
m), genus Turbinaria,
toseira), Jiromoku (Myagropsis), Sugimoku (Coccophora) and the like are used, and preferably Hijiki and Hondawara. Libyanaceae (Fu) used in the present invention
seaweed belonging to the genus Ascophyllum (Asco
phyllum), genus Fucus, genus Pelv
etia) and the like, preferably Ascophyllum or Hibamata. Fungi (Gloiop) used in the present invention
seaweed belonging to the genus Gloiopel
tis) is used. As the seaweed belonging to the family Paramecium (Monostromataceae) used in the present invention, a genus Humane (Monostroma), a genus Motse (Kornmannia) and the like are used, and human genus is preferably. As the seaweed belonging to the family Milliaceae (Codiaceae) used in the present invention, genus Mille (Codium) and the like are used. As the seaweed belonging to the family Bogiaceae (Bangiaceae) used in the present invention, there may be used, for example, a genus Porphyra, a genus Bosh (Bangia), preferably a genus Amanori. The seaweeds belonging to the family Gigartinaceae used in the present invention include genus Gingartina and genus Rhododendron (Rhod).
oglossum) and the genus Chondrus.
Bakkinori (Bonnemaisoniaceae) used in the present invention
As the seaweed belonging to the genus, a genus Asparagopsis, a genus Bonnemaisonia, etc. are used, and the genus genus is preferred. The seaweeds belonging to the family Ibaranori (Hypneaceae) used in the present invention include the genus Ibaranori (Hyne
pnea) and the like are used. The seaweeds belonging to the family Pineaceae (Chordariaceae) used in the present invention include the genus Matsumo (A)
nalipus), Cladosiphon and the like. The spider family (Nemacystacea) used in the present invention
As seaweeds belonging to e), Nemacystis and the like are used. Durvil family used in the present invention (Durvil
leaceae) is a seaweed belonging to the genus Durvill
ea) and the like are used. As seaweeds belonging to the family Lessoniaceae used in the present invention, genus Lessonia, genus Macrocystis and the like are used. The Rhodimenaceae (Rhodymen) used in the present invention
Seaweed belonging to the genus Darus (Rhodymenia)
Are used.

When extracting the effective components of these seaweeds, the seaweeds may be in an undried state, but it is preferable to dry them by a method such as air-drying or freeze-drying before extracting them from the viewpoint of extraction efficiency. There is no limitation on the method of extracting the active ingredient of seaweed, and a normal extraction method is adopted, and extraction is performed from seaweed using water, a sodium chloride solution, a hydrophilic organic solvent, a water-containing hydrophilic organic solvent, or another organic solvent. Is done. As the hydrophilic organic solvent, methanol, ethanol, lower alcohols such as isopropanol, propylene glycol,
Glycols such as 1,3-butylene glycol, glycerin, acetone, methyl ethyl ketone, acetonitrile,
Examples thereof include dimethyl sulfoxide, dimethylformamide and the like, and a mixed solution thereof. In particular, it is preferable to perform extraction using water or a mixture of water and a lower alcohol such as methanol, ethanol, or isopropanol.
In that case, the ratio of water to lower alcohol is preferably such that lower alcohol / water is 0/100 to 70/30 (V / V: volume ratio), more preferably 0/100 to 40.
/ 60.

The ratio of the dried seaweed to the extraction solvent at the time of extraction is preferably such that the ratio of the dried seaweed to the solvent is in a range of 1/50 to 1/2. There is no limitation, but 5 to 80 ° C., preferably 5 to 50 ° C.
It is preferable to carry out the stirring in the temperature range of 1 ° C. for 1 to 24 hours, and there is no particular limitation on the extraction pH unless it is extremely acidic or alkaline. It is also possible to increase the extraction efficiency by repeating the extraction operation on the extraction residue generated in the above extraction operation. In addition, this extract may be used as it is, may be used as a diluent, or may be used as a concentrated extract, or may be prepared as a dry powder by freeze-drying or the like, or may be prepared in a paste form. When it is prepared as a dry powder, it is preferable to use it by dissolving it in water or a lower alcohol such as methanol, ethanol, or isopropanol containing water in advance, or to use it after solubilizing it in an adhesive composition containing water.

The seaweed extract can be blended at any concentration.
0.001 to 20% in the formulation, further 0.001 to 15
%, Particularly preferably 0.001 to 10%.

The external composition for skin of the present invention can be applied to medicines such as ointments, creams, gels, lotions, aerosols, cataplasms, tapes and the like, and cosmetics such as powders, hair tonics and shampoos. In addition, the use of aloe and seaweed extracts incorporated in this composition for the treatment of burns and wounds, the long-lasting effect of improving moisturizing properties and the effect of early recovery of the barrier function are particularly effective. Application to a water-containing cataplasm to calm the skin early.

In the skin external preparation of the present invention, in addition to the above-mentioned seaweed extract which is an essential component, raw materials usually used for skin external preparations, for example, surfactants, oils, alcohols, humectants,
Antioxidants, chelating agents, pH adjusters, UV absorbers / scatterers, amino acids, pharmacologically active substances, aqueous adhesive bases, water-soluble polymeric substances, inorganic powders, preservatives, emulsifiers, hardeners, hardeners , Mineral powder, fragrance, pigment, water and the like can be blended according to the dosage form.

The oils include castor oil, olive oil, cocoa oil, palm oil, camellia oil, coconut oil, wood wax, jojoba oil,
Vegetable oils such as grape seed oil and avocado oil; animal oils such as mink oil and egg yolk oil; waxes such as beeswax, spermaceti, lanolin, carnauba wax, candelilla wax; liquid paraffin, squalane, microcrystalline wax, ceresin Hydrocarbons such as wax, paraffin wax, petrolatum; natural and synthetic fatty acids such as lauric acid, myristic acid, stearic acid, oleic acid, isostearic acid, behenic acid; cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol And natural and synthetic higher alcohols such as isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate. It can be.

Examples of the humectant include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol and dipropylene glycol; NMF components such as amino acids and sodium pyrrolidonecarboxylate; Examples thereof include water-soluble polymers such as acids, collagen, mucopolysaccharides, and chondroitin sulfate.

Examples of antioxidants include dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and salts thereof; and examples of chelating agents include disodium edetate, ethylenediaminetetraacetic acid and salts thereof, pyrophosphoric acid and salts thereof, and hexametaphosphoric acid. And its salts, gluconic acid and its salts, and the like. Examples of the pH adjuster include sodium hydroxide, potassium hydroxide, triethanolamine, aqueous ammonia, boric acid, borax, and potassium hydrogen phosphate. it can.

Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycinnamate, titanium oxide, kaolin, talc and the like.

The amino acids include glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cysteine, methionine, proline, hydroxyproline, aspartic acid,
Examples include glutamic acid, arginine, histidine, lysine, and derivatives thereof.

The pharmacologically active substance used in the external preparation for skin of the present invention includes, for example, antibiotics, chemotherapeutic agents, bacteriostatic
Disinfectants, disinfectants, non-steroidal anti-inflammatory drugs, steroidal anti-inflammatory drugs, anticancer drugs, psychotropic drugs, local anesthetics, anti-Parkinson's agents, sex hormones, anti-perspirants, sunscreens, anti-allergics, anti- Antiarrhythmic, antihypertensive, vasodilator, vasodilator, muscle relaxant, antiemetic, psoriasis treatment, emollient, emollient, prostaglandins, fat-soluble vitamins, enzymes, peptide hormones Diabetics, polysaccharides, plant extracts and essential oils, diagnostics, insecticides, insect repellents, dyes, pesticides and the like. Specific examples of these drugs are as follows.

[Antibiotics] Penicillin G, penicillin
V, methicillin, oxacillin, cloxacillin, ann
Picilin, hetacillin, cyclacillin, amoxicillin
Penicillins such as carbenicillin, sulbenicillin, etc.
Antibiotics. Cephaloridin, cephalotin, cefazoli
Cephalosin, cephaloglysin, cephalexin, etc.
Porin antibiotics. Streptomycin, Kanamaishi
, Dibekacin, gentamicin, fradiomycin, etc.
Aminoglucoside antibiotics. Oxytetracycline
, Tetracycline, dimethylchlorotetracycline
, Doxycycline, minocycline, etc.
Clean antibiotics. Erythromycin, Leucomyci
And macrolide antibiotics such as josamycin. Rin
Lincomycin derivatives such as Comycin and Clindamycin
Raw material. Chloramphenicol, Micamycin, Grammy
Cydin, gramicidin S, capreomycin, cyclo
Serine, Enviomycin, Rifampicin, Nysta
Tin, tricomycin, amphotericin B, griseooff
Rubin, variotin, pyrrolenitrin, siccanin,
Nitrofurantoin, 5-iodo-2-deoxyuridine
, Cefamedin, phosphonomycin, N-form
And imidoylchenamycin monohydrate. [Chemotherapeutic agents] mafenide acetate, sulfadiazine,
Rufadiazine silver, sulfamethoxazole sodium
, Sulfisomidine, sulfisomidine sodium, etc.
Topical sulfa drugs. [Bacteriostatic, disinfectant, disinfectant] iodine, pompidone iodine, diyo
Hydroxypropane, benzalkonium chloride, chloride
Benzethonium, methylrosaniline chloride, hexachloro
Phen, chlorhexidine, benzoyl peroxide
And tolnaftate. [Antifungal agent] naphthiomate, clotrimazole,
Theofulvin, Siccanin, Tricomycin, Nysta
Tin, pyrrolnitrin, exalamide, crocona hydrochloride
Sol, isoconazole nitrate, econazole nitrate, nitric acid
Oxyconazole, sulconazole nitrate, miconazo
Thioconazole, tolcyclate, barioten, ha
Loprozin, phenyl iodoundecylate, bifona
Zole, naftifine, ketoconazole, octopiro
Ox, ciclopirox, olamine, etc.
You. [Non-steroidal anti-inflammatory agent] salicylic acid and its salts, a
Salicylic acid derivatives such as spirin, acetaminophen
, Aminopyrine, antipyrine, oxyphenbutazo
, Sulpyrine, ampfenac sodium,
Tasin, diclofenac sodium, felbinac,
Ibuprofen, sulindac, naproxen, ketop
Lofen, suprofen, etofenamate, salicyl
Amide, triethanolamine salicylate, flufe
Namic acid and its salts and derivatives, meclofenamic acid and
Salts and derivatives thereof, colchicine, bufexama
K, Ibufenac, Loxoprofen, Fenbufe
, Diflunisal, alclofenac, phenylbuta
Dzone, mefenamic acid and its salts and derivatives, pheno
Profen, bendazac, piroxicam, flurbip
Lofen, Zaltoprofen, Etodolac and others
It is. [Steroidal anti-inflammatory drug] Amcinoid, valerate pred
Nizolone, diflucortron valerate, beta meta valerate
Dzone, betamethasone acetate, dexamethasone acetate, zip
Betamethasone lopionate, dexamethasone, triam
Sinolone acetonide, rilcinonide, hydrocortizo
Flumethasone pivalate, fluocinonide, fluocin
Norone acetonide, fluotometron, fludroxico
Lutide, prednisolone, clobetasol propionate
, Beclomethasone propionate, betamethasone, meth
Leprednisolone, methylprednisolone acetate,
Hydrocortisone butyrate and the like. [Anti-cancer agent] 5-fluorouracil, 6-mercaptop
Phosphorus, methotrexate, bleomycin, mitomai
Syn-C, Adriamycin, Carbocon, Actinomy
Syn-C, daunorubicin, neocarzinostatin, black
Momycin A, L-asparaginase, picibanil,
Vinplastin, vincristine and the like. [Psychotropic agents] chlorpromazine, reserpine, chlordi
Azepoxide and the like. [Anti-Parkinson's disease agent] L-dopa, chlorzoxazone
And the like. [Sex hormones] estrogen, androgen, est
Ladiol, testosterone, progesterone, etc.
I can do it. [Antiperspirant] propantheline bromide, scopolami
And quaternary acyloxymethyl ammonium salts.
Can be [Sunscreen agent] p-aminobenzoic acid, p-dimethyl
Aminobenzoic acid or their alkyl esters
And so on. [Anti-allergic agent] diproheptadine hydrochloride
, Sodium cromoglycate, ketotifen, etc.
I can do it. [Antiarrhythmic agent] acebutolol, alprenolol, a
Ndenolol, carteolol, bucmorol, buffet
Troll, bupranolol, propranolol, pind
Rolls and the like. [Anti-hypertensive agent] Laurol such as reserpine and resinamine
Fear alkaloids. Clonidine, prazosin, pear
Dihydroergotoxine luate, methicran, methyl dough
And guanethidine, betanidine and the like. [Vasodilators] efloxate, etaphenone, oxy
Fedrin, carbochromene, dilazep, diltiazem
, Trimetazidine, pentaerythritol tetranitrate, di
Pyridamole, isosorbide dinitrate, trapidil, nitro
Glycerin, nifedipine, preniramine, molsidomi
, Phosphate trol nitrate, inositol hexani
Cotinate, isoxsuprine, nylidrin, citric acid
Nicametate, cyclandate, cinnarizine, nico
Chinic alcohol, hepronikart, etc.
You. [Vascular reinforcing agent] Rutin and the like. [Muscle relaxant] Diazepam and the like. [Antimetic] Chlorpromazine and the like. [Therapeutic agent for psoriasis] Methoxsalen and the like. [Emollient or emollient] hydroquinone, urine
Element, heparin, chondroitin sulfate and the like. [Prostaglandins] Prostaglandin F_Twoα,
Prostacyclin, Prostaglandin E₁, Pros
Tag Landin E_Two, 7-Thiaprostaglandin E₁, 1
6,17,18,19,20-pentanor-15-cycl
Lopentyl-7-thiaprostaglandin E ₁, 16,
16-dimethyl-7-thiaprostaglandin E₁, 1
7,20-dimethyl-7-thiaprostaglandin
E₁, 16,17,18,19,20-Pentanol-1
5-cyclohexyl-Δ^Two-7-Tiaprostagland
E₁, 16,16-dimethyl-Δ^Two-7-Tiaprosta
Grangen E₁, 7-fluoroprostacyclin, 5
-Fluoroprostacyclin, 16, 17, 18, 1
9,20-pentanor-15-cyclohexylprosta
Cyclin, 16, 17, 18, 19, 20-pentano
-15-cyclopentyl prostacyclin
I can do it. [Vitamins] 1,25-dihydroxyvitamin D_Three,
1α-hydroxyvitamin D_Three, 1,24-dihydroxy
Shivitamin D_Three, 24,25-dihydroxyvitamin
D_Three1,1α, 25-dihydroxyvitamin D_Three-26,2
3-lactone, 25-hydroxyvitamin D_Three-26,
23-lactone, vitamin A, vitamin E, tokoff acetate
Hellol, vitamin K, vitamin B group, vitamin C, bi
Tamine F, Vitamin P, Vitamin U, Carnitine, Fe
Luluric acid, γ-oryzanol, α-lipoic acid, orotic acid and
And its derivatives. [Enzyme preparations] Trypsin, papain, protease,
Zozyme, streptokinase, plasmin, urokina
, Hyaluronidase, α-chymotrypsin, serati
Opeptidase, bromelain, semi-alkali peptida
And the like. [Peptide hormone] insulin
Phosphorus, angiotensin, vasopressin, ferripre
Syn, protirelin, gonadotropin-releasing hormone,
Lucicotropin, prolactin, somatropin, silo
Tropine, luteinizing hormone, calcitonin, kallikre
Inn, parasilin, glucagon, oxytocin, gas
Such as trin, secretin, and serum gonadotropin.
I can do it. [Diabetes treatment] Glibenclamide, gliclazide, etc.
Is mentioned. [Polysaccharides] include heparin, chondroitin sulfate, etc.
It is. [Crude drugs] Capsaicin and powder of crude drugs such as psyllium
Or herbal extract such as pepper extract, and dried psyllium
Herbal medicines such as extracts, herbal extracts such as extracts, assembly extracts
Flu extract, crude drug tincture such as arnica tincture, peppermint oil,
Essential oils such as cinnamon oil, cucumber, radish, licorice, verad
Nanna, peonies, mugwort, horse chestnut, (seed
Offspring, buds), chamomile (extract, essential oil)
Ki, sage, birch and the like. The above medicinal ingredients
Are used alone or in combination of two or more.
Can be selected as appropriate
You.

When the above-mentioned pharmacologically active substance is blended with the external preparation for skin of the present invention, if the substance is listed in the Japanese Pharmacopoeia or if the appropriate dosage is determined by other literatures, the appropriate dosage is used. It is preferred to mix them. The compounding amount of other substances for which no particularly suitable use amount is determined is 0.0001 to 10%, preferably 0.001 to 5%.
% Is desirable. If it is lower than 0.0001%, the effect as a pharmacologically active substance is not recognized, and even if 10% or more is added, the effect does not change.

The external preparation for skin of the present invention more preferably uses an aqueous adhesive base containing a crosslinked product of polyacrylic acid and polyacrylate as the aqueous adhesive base. This aqueous pressure-sensitive adhesive base has a high water content, and also has excellent adhesion to the skin. The crosslinked product of polyacrylic acid and polyacrylate is not particularly limited, and known ones can be used. For example, JP-A-59-110614, JP-A-59-110616, and JP-A-59-110617 can be used. No. 6
Nos. 0-99180, 60-260512, 60-
An aqueous pressure-sensitive adhesive base containing a metal crosslinked product of polyacrylic acid and polyacrylate described in 260513 or the like is preferable.

Specifically, any of the polyacrylic acids of the aqueous pressure-sensitive adhesive base used in the present invention can be used.
There is no particular limitation on the molecular weight and the shape such as straight-chain or branched-chain, but it is preferable to use those having a molecular weight of 10,000 to 10,000,000, and particularly those having a weight-average molecular weight of 10,000 to less than 500,000.
500,000 to less than 2,000,000, when two or more polyacrylic acids having an average molecular weight of 2,000,000 to 4,000,000 are combined,
This is preferable because the feeling of use is improved. In addition to a polymer obtained by polymerizing ordinary acrylic acid, a partially crosslinked acrylic acid polymer such as Carbopol (trade name: manufactured by Goodrich Corporation, USA) can be suitably used.

Examples of polyacrylates include monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, monoethanolamine polyacrylate, diethanolamine polyacrylate, triethanolamine polyacrylate and the like. One or two of amine salt of polyacrylic acid, ammonium salt of polyacrylic acid, etc.
More than one species may be suitably used.

Here, the mixing ratio (weight ratio) of polyacrylic acid and polyacrylate is preferably 1: 0.1 to 1:10, particularly preferably 1: 1 to 1: 9. An acid or salt partially neutralized so that the polyacrylate has the above ratio may be used. Further, the total blending amount of polyacrylic acid and polyacrylate is preferably 0.5 to 20%, particularly 1 to 15% of the whole composition, and if it is less than 0.5%, the adhesive strength may be insufficient. Yes, if it exceeds 20%, the viscosity becomes high, which may cause a problem in workability during production.

As the aqueous adhesive base, it is preferable to use one obtained by crosslinking polyacrylic acid and polyacrylate by adding an appropriate crosslinking agent. As such a crosslinking agent, polyacrylic acid and polyacrylate are preferably used. The type is not particularly limited as long as it can crosslink with the polyacrylate, but a polyvalent metal compound is particularly preferably used. In this case, as the polyvalent metal compound, a magnesium compound, a calcium compound,
Zinc compounds, cadmium compounds, aluminum compounds,
Titanium compounds, tin compounds, iron compounds, chromium compounds, manganese compounds, cobalt compounds, nickel compounds, etc. can be used, but if considering safety to the skin, aluminum compounds, magnesium compounds, calcium compounds, etc. may be used. preferable.

In this case, any of the aluminum compound, magnesium compound and calcium compound can be suitably used, for example, alums such as potassium alum, ammonium alum, iron alum, aluminum hydroxide, aluminum sulfate, aluminum ammonium sulfate, and the like. Potassium aluminum sulfate, aluminum chloride, dihydroxy aluminum amino acetate, aluminum acetate, aluminum oxide, synthetic aluminum silicate, aluminum metasilicate, calcium hydroxide, calcium carbonate, calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, calcium phosphate , Magnesium hydroxide, magnesium carbonate,
Water-soluble compounds such as magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide, alumina / magnesium hydroxide, magnesium aluminate metasilicate, magnesium aluminate silicate, synthetic hydrotalcite, double salts containing these metals, etc. One or more of the soluble compounds may be used.

Here, the suitable amount of the crosslinking agent varies depending on the kind thereof. For example, when the above-mentioned polyvalent metal compound is used, the amount is preferably 0.001% of the whole composition.
-10%, particularly preferably 0.01-5%. If it is less than 0.001%, the cohesive strength of the composition may decrease, and if it exceeds 10%, the adhesive strength may decrease.

Further, the composition for external use on skin of the present invention includes:
Cellulose derivatives and polyhydric alcohols can be added as long as the effects of the present invention are not impaired. In this case, any of the cellulose derivatives may be used, for example, one or two of alkali metal salts of carboxymethyl cellulose, hydroxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methyl cellulose and the like.
More than one species can be used, but alkali metal salts of carboxymethyl cellulose such as sodium carboxymethyl cellulose and potassium carboxymethyl cellulose can be particularly preferably used. In addition, when adding a cellulose derivative, it is preferable that the compounding quantity is 15% or less of the whole composition. If it exceeds 15%, the viscosity will be high, which may cause a problem in workability during production. In addition, as the polyhydric alcohol, any of those usually used can be used,
For example, glycerin, sorbitol, ethylene glycol, diethylene glycol, triethylene glycol,
Polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-butylene glycol,
1,3-propanediol, 1,4-butanediol,
One or more of maltitol and xylitol may be used. In addition, when adding a polyhydric alcohol, it is preferable that the compounding quantity is 50% or less of the whole composition. If it exceeds 50%, the cohesive force of the aqueous pressure-sensitive adhesive base is reduced, and the aqueous pressure-sensitive adhesive base may remain on the adherend during peeling.

As water-soluble high molecular substances of polyacrylic acid, polyacrylate and cellulose derivative, polyvinyl alcohol, polyvinyl pyrrolidone, gelatin,
Pectin, vinylpyrrolidone / vinyl acetate copolymer, hydroxypropylcellulose, sodium alginate, xanthan gum, tragacanth and the like can be blended.
When these water-soluble polymers are blended, the blending amount is preferably 0 to 10% of the whole external preparation composition. 10
%, The plaster becomes hard, which causes a problem when it is manufactured as a patch such as a poultice.

Further, silicone or liquid paraffin can be blended in order to improve the releasability of the plastic film of the patch. The content of these is 0.1 to 20.0% of the whole patch composition, preferably 0.3 to 0.3%.
１10.0%, more preferably 0.5 to 5.0%. When the amount is 0.1% or less, the effect of improving the peeling of the film is not seen, and when the amount is 20% or less, the film slips on the patch composition and loses its value as a product. in this case,
As the silicone, either a silicone resin or a silicone oil can be used without any problem. For example, silicone resin, methylphenylpolysiloxane,
Methylpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, polyoxyethylene methylpolysiloxane copolymer, polyoxypropylene Methylpolysiloxane copolymer, poly (oxyethyleneoxypropylene) methylpolysiloxane copolymer, methylhydrogenpolysiloxane, tetrahydrotetramethylcyclotetrasiloxane, stearoxymethylpolysiloxane, ethoxymethylpolysiloxane, methylpolysiloxane emulsion Highly polymerized methylpolysiloxane, trimethylcycloxysilicic acid, and cross-linked methylpolysiloxane can be suitably used. Further, as liquid paraffin, light liquid paraffin and heavy liquid paraffin can be used. These silicones and / or liquid paraffins may be used alone or in combination of two or more. These silicones and / or liquid paraffins are blended in a state of being mixed with other oily components.

Preservatives include aminoethylsulfonic acid, benzoic acid, sodium benzoate, benzyl benzoate, anthracite, liquid phenol, ethanol, sodium edetate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, dried sodium sulfate , Agar, dl-camphor, strong sump leather N
(Trade name: Saneigen F.F.I.), citric acid, sodium citrate, chlorocresol, chlorobutanol, gentisic acid ethanolamide, salicylic acid, sodium salicylate, dibutylhydroxytoluene, 2,6-di-t -Butyl-4-methylphenol,
Secept (trade name: manufactured by Seiwa Kasei Co., Ltd.), sorbic acid, potassium sorbate, nitrogen, thymol, dehydroacetic acid, sodium dehydroacetate, 2-naphthol, hinokitiol, sucrose, honey, isobutyl parahydroxybenzoate,
Isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, paraformaldehyde, phenylethyl alcohol, phenol, proxel GXL (trade name: manufactured by Zeneca), benzyl alcohol, boric acid Borax, d-borneol, l-menthol, eucalyptus oil, oxyquinoline sulfate, isopropylmethylphenol, undecylenic acid monoethanolamide, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, alkyldiaminoethyl hydrochloride Glycine solution, chlorhexidine hydrochloride (gluconic acid),
Orthophenylphenol, cresol, chloramine T, chlorxylenol, chlorphenesin, alkylisoquinolinium bromide solution, domiphen bromide, thianthol, trichlorocarbanilide, parachlorphenol,
Halocarban, 2- (2-hydroxy-5-methylphenyl) benzotriazole, hexachlorophen, resorcin, phenoxyethanol and the like can be added.

Examples of the emulsifier include methyl acrylate / -2-ethylhexyl acrylate copolymer resin emulsion,
Sodium N-acyl-L-glutamate, Atmos 3
00 (trade name: manufactured by Kao Corporation), Amacol CAB (trade name: manufactured by Eikodo), allyl glycidyl ether, ethanol, ethylene glycol monomethyl ether, emamin D500B (trade name: manufactured by Kyoeisha Yushi Kagaku Kogyo), Emarex AC -10 (trade name: manufactured by Nippon Emulsion Co., Ltd.), cetylpyridinium chloride, benzalkonium chloride, alkyldiaminoethyl glycine hydrochloride, Eimulgin C1000 (trade name: manufactured by Henkel Hakusui), octyldodecanol, oleyl alcohol, carrageenan,
Potassium soap, carboxyvinyl polymer, carmellose sodium, reduced lanolin, guar gum, Claude base 25 (trade name: manufactured by Takada Koryo Co., Ltd.), glycerin, highly purified egg yolk lecithin, Sanimaru 234NS (trade name: manufactured by Nippon Emulsifier) Sanimaru 235 (same as above), Sanimaru 250
-C (same), Sanimaru 250C (75) (same), Sanimaru 258B2 (same), Sanimaru 258BA (same), Sanimaru 258BA2 (same), Sanimaru 258N (same), Sanimaru 265 (same), Sanimaru 451-KT ( Sanimaru 55-HX (same), Sanimaru 55-LX (same),
Sanimaru DVP (same), Sanimaru K-51 (same), Sanimaru K-51 (75) (same), Sanimaru PCS (same),
Sanimaru SN-155 (same as above), Sanimaru ST-451
(Same as above), beeswax, diisopropanolamine,
Diethylene glycol monobutyl ether, dioctyl sodium sulfosuccinate, self-emulsifying glyceryl monostearate, polyethylene glycol distearate, dicetyl phosphoric acid, sodium dibnate, sucrose fatty acid ester, lipophilic glyceryl monooleate, lipophilic monostearic acid Glycerin, potassium hydroxide, sodium hydroxide, hydrogenated soybean phospholipids, hydrogenated lanolin alcohol, squalene, squalane, stearyl alcohol, stearic acid, potassium stearate, sodium stearate, polyoxyl 40 stearate,
Purified soy lecithin, purified lanolin, purified egg yolk lecithin,
Sorbitan sesquioleate, cetanol, sodium cetyl sulfate, cetostearyl alcohol, cetomacrogol 1000, diethyl sebacate, gelatin, D-sorbitol, sorbol 200 (trade name: manufactured by Toho Chemical Industry Co., Ltd.), sorbol 2242 (same as above), solpol 253
9A (same), Solpol 2500A (same), Solpol 2540A (same), Solpol 2676-S (same), Solpol 2720 (same), Solpol 2721 (same),
Solpol 2850A (same as above), Solpol 2852
(Same), Solpol 2942-S (same), Solpol 2
944-S (same), Solpol 3006-K (same), Solpol 3006A (same), Solpol 3006DB
(Same), Solpol 3008-K (Same), Solpol 3
008A (same), Solpol 3080 (same), Solpol 3269 (same), Solpol 50 (same), Solpol 900A (same), Solpol 900B (same), Solpol AC-2357A (same), Solpol AC-2411
A (same), Solpol AC-2721A (same), Solpol AE102 (same), Solpol M2242 (same),
Solpol SM-100P (same as above), Solpol SM-1
00S (same), Solpol SM-200 (same), Solpol TM2 (same), soybean lecithin, talc, calcium carbonate, medium-chain fatty acid triglyceride, neutral anhydrous sodium sulfate, polyoxyethylene sorbite tetraoleate, dehimulus E (product) Name: Henkel Hakusui), kerosene, Toxanone V1D (trade name: Sanyo Chemical Industries),
Toxanone XK-30 (same as above), dodecylbenzenesulfonic acid, polyoxyethylene glyceryl triisostearate, polyoxyethylene glycerin triisostearate (3EO), triethanolamine, sorbitan trioleate, polyoxyethylene trioleate Sorbitan (20EO), sorbitan tristearate, Nikkor PBC-14 (trade name: manufactured by Nikko Nikko Chemicals), Nikkor wax 220 (same), emulsifier AC2338A (trade name: manufactured by Toho Chemical Industry), New Calgen 1015 (trade name: manufactured by Takemoto Yushi Co., Ltd.), Newcargen 1015-P (same as above), Newcargen 1066
K (the same), New Cargen 1070 (the same), New Cargen 1071 (the same), New Cargen 1500TE1
(Same as above), New Cargen 1585TE1 (Same as above), New Cargen 1616-D1 (Same as above), New Cargen 161
6-D6 (same), Newcargen 1616M (same), Newcargen 165 (same), Newcargen 185-K
4 (the same), New Cargen 1880SB (the same), New Cargen 204 (the same), New Cargen 2119-K
(Same as above), New Cargen CP-120 (same as above), New Cargen EP3 (same as above), New Cargen KH-13
(Same as above), New Cargen KH-15 (Same as above), New Cargen KH-20M (Same as above), New Cargen KH-25
(Same as above), New Cargen KL-13 (same as above), New Cargen KL-20M (same as above), New Cargen KL-26
(Same as above), Newcol NN15 (trade name: manufactured by Nippon Emulsifier Co., Ltd.), Newpol LB-65 (trade name: manufactured by Sanyo Chemical Industries, Ltd.), Heimar 212 (trade name: manufactured by Matsumoto Yushi Seiyaku Co., Ltd.), Heimaru CX-8C (Trade name: manufactured by Matsumoto Yushi Seiyaku Co., Ltd.), Hymal PS-90A (same as above), paraffin, nonionic self-emulsifying wax, hydroxypropylcellulose, propylene glycol, propylene glycol fatty acid ester, pectin, hostafat KW-340
(Trade name: manufactured by Hoechst), polyoxyethylene (2
0) Polyoxypropylene (4) cetyl ether, polyoxyethylene alkyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene oleyl ether, sodium polyoxyethylene oleyl ether phosphate, polyoxyethylene stearyl ether, polyoxyethylene cetyl ether Phosphoric acid, polyoxyethylene cetyl ether, sodium polyoxyethylene cetyl ether phosphate (5EO), polyoxyethylene sorbit beeswax, polyoxyethylene sorbit beeswax (6EO), polyoxyethylene castor oil, polyoxy Ethylene behenyl ether, polyoxyethylene behenyl ether (20EO), polyoxyethylene (160) polyoxypropylene (3
0) glycol, polyoxyethylene lauryl ether, polyoxyethylene lanolin, polysorbate 4
0, polysorbate 60, polysorbate 65, polysorbate 80, macrogol 20000, macrogol 300, macrogol 400, myristyl alcohol,
Isopropyl myristate, octyldodecyl myristate, methyl cellulose, methyl naphthalene, α-monoisostearyl glyceryl ether, sorbitan monooleate, polyethylene glycol monooleate, polyoxyethylene sorbitan monooleate (6E.
O. ), Ethylene glycol monostearate, glyceryl monostearate, sorbitan monostearate,
Propylene glycol monostearate, polyethylene glycol monostearate, polyoxyethylene glycerin monostearate, polyoxyethylene sorbitan monostearate (6EO), sorbitan monopalmitate, polyethylene glycol monolaurate (10EO) monolaurin Acid polyoxyethylene sorbitan (20EO), medicinal soap, coconut fatty acid,
Coconut fatty acid diethanolamide, N-lauroyl-L-
Sodium glutamate, lauromacrogol, lauromacrogol (6EO), lauromacrogol (9
E. FIG. O. ), Egg yolk oil, egg yolk phospholipids, liquid paraffin,
Decaglycerin fatty acid ester, pentaerythritol fatty acid ester, polyoxyethylene alkyl ether,
Polyoxyethylene phytostanol, polyoxyethylene lanolin alcohol / beeswax derivative, polyoxyethylene alkylamine / fatty acid amide, polyoxyethylene alkylphenylformaldehyde condensate, alkyl sulfate, polyoxyethylene alkyl ether sulfate, N-acyl amino acid and Salt, N-acylmethyltaurine salt, polyoxyethylene alkyl ether acetate, alkyl sulfocarboxylate, α-olefin sulfonate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, alkyl ammonium salt, alkyl Benzyl ammonium salt, betaine acetate, imidazolium betaine, lecithin, fatty acid ester, polyhydric alcohol fatty acid ester, alkyl glyceryl ether and fatty acid ester, higher grade Alcohol, hydrocarbons, natural animal and vegetable oils, vitamin derivatives, glycyrrhizinic acid, may be added such as glycyrrhetinic acid and derivatives thereof.

The type of the curing agent is not particularly limited, and those conventionally used in plasters can be used. In the case of the present invention, the respective components are uniformly mixed and the plaster ( Patch composition) is prepared, and from the viewpoint of uniformly applying the plaster to a cloth, a film, or the like in the subsequent spreading step, those which act gradually are preferable to those which act immediately, and such curing Examples of the agent include magnesium aluminate silicate, magnesium aluminate hydroxide, magnesium aluminate metasilicate, synthetic hydrotalcite, dihydroxyaluminum aminoacetate, and the like. These may be used alone or in an appropriate combination of two or more. can do.

The amount of the curing agent in the patch composition can be appropriately selected depending on the type thereof, the type of the water-soluble polymer used in combination, and the like. 3%, preferably about 0.03 to 1%. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if the amount is too large, it may be difficult to adjust the curing speed.

The type of the curing regulator for adjusting the curing by the curing agent is not particularly limited, and those conventionally used in plasters can be used. For example, citric acid, malic acid, tartaric acid, disodium edetate and the like can be mentioned, and these can be used alone or in an appropriate combination of two or more. The compounding amount of the curing regulator can be appropriately selected, and is usually 0.001% of the entire patch composition.
10% to 10% is preferred. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if the amount is too large, it may be difficult to adjust the curing speed.

The type of the mineral powder is not particularly limited, and those conventionally used for plasters can be used. Examples of such a mineral powder include kaolin, bentonite and montmorillonite. , Zinc oxide, titanium oxide, silicic anhydride and the like.
The species can be used alone or in combination of two or more. The blending amount of the curing regulator can be appropriately selected, but is usually about 1 to 10%, more preferably 4 to 6%, of the whole patch composition. If the amount is too large, the plaster hardness may be so high that it cannot be spread.
On the other hand, if the amount is too small, the shape-retaining property of the plaster deteriorates, and the back stain occurs.

The type of the fragrance is not particularly limited, and those which have been conventionally used as fragrances such as poultices can be used. Examples of such fragrances include anise, angelica, benzoin, immortelle, Chamomile, garlic, cardamom, galvanum, caraway, carrot seed, guarack wood, grapefruit, orange, cypress, sandalwood,
Cedarwood, juniper, star anise, sage, geranium, celery, thyme, tarragon, turpentine, spruce, frankincense, violet, pine, parsley, birch, patchouli, rose, hyssop, fennel, black pepper, bodaige flower, myrrh, yalow, lemon , Lemongrass, rosemary, laurel, sycamore, peach,
Cornflowers, eucalyptus, yuz, lavender, fennel, daikon, keihi, chouji, thiamine, turpentine, henopposite, yamajin, touka, bergamot,
Herbal essential oils or extracts such as citronella, geranium, etc., other lower alcohols, aldehydes and the like can be mentioned, and these can be used alone or in appropriate combination of two or more. The blending amount of the fragrance can be appropriately selected, but is usually preferably about 0.0001 to 1% based on the whole patch composition. If the amount is too small, the effect of the compounding will not be sufficiently obtained, and if it is too large, skin irritation may occur.

Examples of the substance imparting a refreshing sensation include l
-Menthol, N-substituted-p-menthan-3-carboxamide, 3-substituted-p-menthane, 2- or 3-substituted-
Examples thereof include p-menthanediol and trialkyl-substituted cyclohexanecarboxyamide. These can be used alone or in combination of two or more. Among them, l-menthol is particularly useful for analgesic and anti-inflammatory. Preferably, l-menthol is used alone or in combination with another cooling agent. When l-menthol is used, l-menthol is used.
Menthol itself may be blended, or it may be blended as it is in the essential oil as a fragrance component, such as peppermint oil, and these may be used in combination.

The amount of the substance that imparts a refreshing sensation is 0.001 to 5%, particularly 0.01 to 2% of the whole external preparation composition.
% Is preferable. If the amount is less than 0.001%, the effect of the substance may not be sufficiently obtained,
If it exceeds 5%, the feeling of irritation to the skin may increase.

The type of the pigment is not particularly limited, and pigments conventionally used in external preparations for skin can be used. Examples of such pigments include Red No. 2, Red No. 3, Red No. 102, Red No. 104, Red No. 105, Red No. 106, Red No. 201, Red No. 202
No. Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213
No. Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223
No., Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230 (1), Red No. 230 (2), Red No. 231, Red No. 232, Red No. 401,
Red 404, Red 405, Red 501, Red 50
No. 2, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Yellow No. 4, Yellow No. 5, Yellow No. 201, Yellow No. 202 (1), Yellow No. 202 (2), Yellow No. 203
No. 204, Yellow No. 205, Yellow No. 401, Yellow No. 402, Yellow No. 403 (1), Yellow No. 404, Yellow No. 405, Yellow No. 406, Yellow No. 407, Green No. 3, Green No. 201, Green No. 202, Green No. 204, Green No. 205
No., Green No. 401, Green No. 402, Blue No. 1, Blue No. 2
No., Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404
No., Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401
No. 402, Orange No. 403, Brown No. 201, Purple No. 201, Purple No. 401, Black No. 401, etc., and these can be used alone or in an appropriate combination of two or more. The amount of the dye can be appropriately selected, but is usually 0.00005 to 0.1%, particularly 0.0001 to 0.0%, based on the whole external preparation composition.
About 1% is preferable, and imparts a color to the external preparation composition,
Preference such as comfort of appearance can be enhanced. If the blending amount is too small, the effect of the blending will not be sufficiently obtained,
If the amount is too large, the color tone may be too strong. When the pigment is added to the external preparation composition, the pigment is dissolved in water, fat, alcohol, or the like, and then kneaded with other components so as to prevent shading and spots of the pigment when the composition is spread. Is preferred.

When the composition for external use on the skin of the present invention is applied to a water-containing cataplasm, the content of water in the composition is 30 to 8
0%, preferably 35-75%, most preferably 40-
70%. If the water content is too low, the absorbability of the medicinal component is inferior, and the feeling of use is lowered. If the water content is too high, the adhesive tends to sag or stain on the back. This water-containing cataplasm is made uniform by a known method by adding a seaweed extract as an essential component, a desired component selected from the above-mentioned components according to the use form and an appropriate amount of water. To prepare a patch composition by kneading, apply it to a suitable support such as cotton cloth, non-woven fabric of synthetic fiber or plastic film, spread it to a uniform thickness, and then apply it to a plastic film or cotton cloth, It is produced by sticking a synthetic fiber non-woven fabric. Here, the cut shape and size of the water-containing cataplasm are not particularly limited, and cataplasms, adhesive plasters, skin treatment sheets for improving skin moisture and fine lines, cosmetic sheets, skin disease treatment patches, transdermal A shape suitable for application as an absorbent preparation or the like, for example, a rectangle, a band, or a shape suitable for sticking to the nose or cheek can be provided. When using a plastic film, the film material is preferably polyethylene, polyethylene terephthalate, or polypropylene. These films may be surface-treated with silicone or the like for the purpose of improving the releasability of the plaster at the time of production or use of the patch.

[0046]

EFFECTS OF THE INVENTION The composition for external use on skin of the present invention comprises aloe and / or aloe extract; Ulvaaceae, Ogonoriaceae, Tenguaceae, Mirinaceae, Kombuaceae, Ainuwakameaceae, Hondawaraaceae, Hibamataaceae, Funoriaceae. As an active ingredient, at least one selected from extracts of seaweed belonging to the family Paramecidae, Milliaceae, Oxaceae, Cypressaceae, Kaginoriaceae, Ibaranoriaceae, Nagamatsumoe, Mokkuaceae, Daviriaceae, Lessoniaceae and Darusaceae. It is characterized by being blended. By combining and combining aloe and seaweed extract in this way, the therapeutic effect of aloe on mild wounds and burns, the sustained effect of improving the moisturizing properties of seaweed extract and the early recovery of the barrier function of the skin stratum corneum The effect works synergistically to reduce inflammation of the skin, restore moisturizing properties and provide a firmer freshness when used on skin damaged by sunburn, burns, wounds, etc. As a result, the skin external preparation composition of the present invention enhances the mild skin treatment effect of aloe, reduces the amount of aloe, and is effective in treating skin wounds, burns, soothing sunburn, etc. It is possible to provide a novel aloe-containing composition for external use.

[0047]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples.

Each component described in Table 1 was mixed and sufficiently mixed with a kneader until a paste was obtained to prepare a patch composition. The obtained patch composition was coated on a nonwoven fabric at 150 g / m
Apply evenly to ² and apply polypropylene,
A patch was prepared. Next, an anti-inflammatory test (sunburn model test) was performed to compare the differences in these anti-inflammatory effects.

[0049]

[Table 1]

<Anti-Inflammatory Test (Sunburn Model Test)> The hair on the back of a Hartley-type guinea pig female (Japan SLC) was clipped with a clipper and a razor 24 hours before the test. After that, the hair was further shaved with an electric razor at least 3 hours before the irradiation with ultraviolet rays, covered with aluminum foil, and eight holes of 1 cm were made as irradiation sites. Next, the lamp was set at a height of 1.0 mW using an ultraviolet irradiator, and
Irradiation with 0 mJ of ultraviolet light was performed for 10 minutes. After irradiation, the four sides of the hole were marked with magic and the aluminum foil was removed. Paste the patches of the above Examples and Comparative Examples to those irradiated sites,
Furthermore, the state after 2, 3, 5 and 24 hours was visually observed, including the non-treated one without sticking. Table 2 summarizes the results.

[0051]

[Table 2]

As is evident from the above results, the patch containing a small amount (0.1%) of aloe and Darbilia has a higher anti-inflammatory effect than that of the non-treated patch, and the patch containing 2.0% of aloe alone contains aloe. It was recognized that the same effect as in the case (Comparative Example) was obtained. Furthermore, in place of the components in Table 1 and the derbilia extract, it may be used in the following manners: Ulvaaceae, Ogonoriaceae, Promenaceae, Myrinaceae, Laminariaceae, Ainuwakameidae, Hondawaraceae, Hibamataaceae, Funoriaceae, Hyotenaceae, Miraceae, Oxaceae The same test was carried out using the same amount of extracts of seaweeds belonging to the family A., Sinoriaceae, Sinenidae, Ibaranori, Sagamatsu, Mopaceae, Lessoniaceae and Darusceae, and the same test was carried out. And the same anti-inflammatory effect as the D. bililia extract.

<Measurement of TWL (Transepidermal Water Evaporation)> Based on the formulation of the example shown in Table 1, a mixture of both Darvillea and aloe (same as the example; Darvillea +
Aloe), a mixture containing only aloe without blending Darbia (referred to as aloe), and a mixture containing only Darvillea without blending aloe (referred to as Darvillea). The change in TWL (transepidermal water loss) was examined in comparison with the control. TWL is TEWA METER
Using a probe (manufactured by Eurotech Japan), the probe was applied to the skin surface and measured. Measurement conditions were constant temperature and constant humidity (20 ° C, 50 ° C).
% RH). First, the TWL of the back of a tanned person (n = 40) was measured (20 ° C., 50% RH). As a result, TWL was 45 ± 10 g / m ² · hr. Next, the above patches (1) to (5) were applied to a measurement site, and after 8 hours, peeled off, and the TWL of that portion was measured. TWL after peeling: Control (no patch; n = 10): 35 ± 3 g / m ² · hr Darvila (n = 10): 17 ± 4 g / m ² · hr Aloe (n) = 10) 20 ± 5 g / m ² · hr · Daviria + Aloe (n = 10) ··· 10 ± 2 g / m ² · hr From the TWL measurement results, as in the present invention, Aloe and Darvillea (seaweed) Extract)
TWL, which is an index of the barrier function of the stratum corneum, is significantly reduced,
It was confirmed that the composition according to the present invention was excellent in the “effect of early recovery of barrier function of skin stratum corneum”.

<Examples of Composition> Table 3 shows examples of the composition of a water-containing cataplasm to be applied to the face or body as a specific example to which the skin external preparation composition of the present invention is applied.

[Table 3]

────────────────────────────────────────────────── ─── Continued on the front page (51) Int.Cl. ⁶ Identification code FI A61K 35/80 ADA A61K 35/80 ADAZ (72) Inventor Kimiko Inoue 1-3-7, Honjo, Sumida-ku, Tokyo Rio Inc.

Claims (2)

[Claims] 1. Aloe and / or an aloe extract, Ulvaaceae, Gracilariacea
e), Tenguaceae (Gelidiaceae), Myrinaceae (Solieria)
ceae), Laminariaceae (Laminariaceae), Ainuwaname (Alariaceae), Hondawara (Sargassaceae), Hibamata (Fucaceae), Funori (Gloiopeltidaceae),
Dermataceae (Monostromataceae), Miraceae (Codiacea)
e), Bossaceae (Bangiaceae), Sinori (Gigar
tinaceae), Bakkinori (Bonnemaisoniaceae), Ibaranori (Hypneaceae), Pinus family (Chordariacea)
e), Nemacystaceae, Durvaceae (Durv
A skin external preparation composition comprising, as essential components, at least one seaweed extract selected from seaweed extracts belonging to the family of lesaceae, Lessoniaceae and Rhodymeniaceae. 2. The composition for external use on skin according to claim 1, wherein the dosage form is a water-containing cataplasm.