JPH10265373A - Tacky adhesive composition and poultice - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a tacky adhesive composition having a gel strength optimum for the spreading work at the end of kneading and the end of the spreading on a substrate, having optimum elasticity after the formation of cross-linked structure and moderately adhering to the skin and to provide a poultice provided with the composition. SOLUTION: This tacky adhesive composition contains a water-based tacky adhesive base containing a water-soluble polymeric material, a metal cross- linking agent for forming a cross-linked structure of the water-soluble polymeric material and an amino acid and/or a compound of the metal cross-linking agent and an amino acid as essential components. The gel strength of the composition is 2-15 mm at the end of the kneading of the essential components with other components containing solvent and at the end of the spreading of the composition on a substrate and the elastic modulus of the composition is 50-400 g/cm<2> after the formation of the cross-linked structure. The poultice is produced by spreading the tacky adhesive composition on an substrate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a pressure-sensitive adhesive composition used for an external skin patch such as a poultice, and more particularly, to a gel strength at the end of kneading and at the end of spreading on a support material. The present invention relates to a pressure-sensitive adhesive composition which has an optimum value for spreading work, has an appropriate elasticity after formation of a crosslinked structure, and has an appropriate level of adhesion to the skin, and a poultice comprising the composition.

[0002]

2. Description of the Related Art A cataplasm using an aqueous adhesive base suppresses inflammation by endothermic action (compressing) and reduces pain, as well as local acute inflammation accompanying heat generation such as bruising and spraining. It is a useful dosage form that promotes skin penetration of medicinal ingredients by the action of water and enhances the therapeutic effect. Such poultices have excellent water retention, high water content, and do not cause solidification, water separation, bleeding, etc., excellent shape retention, no dripping, etc., and have moderate tackiness. However, it has such characteristics that it can be used immediately by simply pasting it in a timely and convenient manner.

[0003] Conventional cataplasms include kaolin, gelatin,
Based on glycerin, this is mixed with other water-soluble polymer substances such as sodium polyacrylate and sodium carboxymethylcellulose, active ingredients, water, etc., and kneaded.
Paste or rice cake-shaped plaster is coated on a support such as cloth. Usually, polyhydric alcohols such as glycerin, propylene glycol, and sorbitol, urea, and highly hygroscopic and deliquescent to increase water retention Along with mixing alkaline earth metals such as magnesium chloride into the plaster, water-soluble polymer substances are added to polyvalent metal ions to enhance shape retention.
Crosslinking with aldehydes, epoxy compounds and the like has been performed. However, water retention and shape retention are mutually exclusive properties; increasing water retention lowers shape retention, and conversely, increasing shape retention decreases water retention and causes solidification, water separation, and bleeding And it is difficult to improve both water retention and shape retention in a well-balanced manner. In addition, when a water-soluble polymer is cross-linked with a polyvalent metal salt to enhance shape retention, the reaction of metal ions of the polymer (electrolyte) generally belongs to an inorganic reaction, and the reaction is extremely fast. (Especially in the case of soluble salts) Since the reaction occurs at the same time as the addition, non-uniform cross-linking and gelation occurs partially, so that a uniform plaster cannot be obtained or the viscosity rises during the coating process of the plaster on the support. The problem is that the coating cannot be performed uniformly and remarkably.

For the purpose of improving the water retention and shape retention of a poultice, the invention disclosed in Japanese Patent Publication No. 3-38244 has been proposed. The invention described in this publication proposes a poultice comprising a plaster containing a water-soluble polymer substance and a polyvalent metal derivative of an amino acid or a polyvalent metal salt of an amino acid. Further, as a poultice having the same composition, there is one described in JP-A-6-279288.
The invention described in the publication discloses (a) piroxicam as an active ingredient, (b) a water-soluble polymer having a carboxyl group in the molecule and / or a salt thereof, (c) an amino acid aluminum complex, and (d) water. It is a poultice having a hydrophilic plaster having a pH of 5.5 to 8.0.

[0005] By the way, the cataplasm needs to be held on the skin for a predetermined time without peeling off from the skin surface, and at the same time, it has to be in close contact with the skin. Products. Therefore, the pressure-sensitive adhesive layer is required to have a certain strong adhesive force. However, if the adhesive strength of the adhesive layer is too large, the hair will be peeled off when the cataplasm is peeled off,
Skin irritation is likely to occur due to high skin irritation. Further, a base material having a large adhesive strength has a high viscosity and has a problem in productivity. Conversely, when the adhesive strength of the adhesive layer is reduced, the hair of the skin is peeled and the irritation to the skin is reduced, but such a cataplasm is easily peeled off from the skin surface and has extremely poor usability. . Further, when producing a poultice, the adhesive composition obtained by mixing the aqueous adhesive base with a metal crosslinking agent such as an amino acid aluminum complex, and other components such as water is supported on a nonwoven fabric or a cotton cloth. It must be applied evenly to the body. Therefore, after kneading each component, the time required for the operation of applying to the support is maintained at a suitable viscosity for the application work, and after applying the pressure-sensitive adhesive composition to the support, a suitable adhesiveness is applied when applied to the skin. It has been desired to provide a pressure-sensitive adhesive composition capable of obtaining good properties.

[0006]

SUMMARY OF THE INVENTION The present invention has been made in view of the above circumstances, and the gel strength at the end of kneading and at the end of spreading on a support material has an optimum value for spreading work, and the cross-linking has been completed. It is an object of the present invention to provide a pressure-sensitive adhesive composition which has an appropriate elasticity after a structure is formed and adheres moderately to the skin, and a cataplasm provided with the composition.

[0007]

The pressure-sensitive adhesive composition of the present invention comprises an aqueous pressure-sensitive adhesive base containing a water-soluble polymer, a metal cross-linking agent for forming a crosslinked structure of the water-soluble polymer, and an amino acid. And / or contains a compound of a metal crosslinking agent and an amino acid as an essential component, and has a gel strength of 2 to 2 at the time of completion of kneading of the above essential component and other components including a solvent and at the time of completion of spreading to a support material. 15, and the elasticity after formation of the crosslinked structure is 5
It is characterized by being 0 to 400 g / cm ² . The poultice of the present invention is obtained by spreading the above-mentioned pressure-sensitive adhesive composition on a support material.

The pressure-sensitive adhesive composition of the present invention comprises a water-soluble pressure-sensitive adhesive containing a water-soluble polymer, a metal crosslinker for forming a crosslinked structure of the water-soluble polymer, and a water-soluble polymer. An amino acid that delays the formation of a crosslinked structure is an essential component, and after kneading the essential component and other components including a solvent, the gel strength becomes suitable for application to a support, and then the elasticity is 50 to 400 g. / Cm ² , after kneading each component, the time required for the operation of applying to the support is maintained at a gel strength suitable for the application work, and after applying the pressure-sensitive adhesive composition to the support, When applied to the skin, appropriate adhesiveness and adhesion are obtained.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The pressure-sensitive adhesive composition of the present invention is prepared by adding a water-soluble polymer-containing aqueous pressure-sensitive adhesive base to a salt of a polyvalent metal forming a crosslinked structure of the water-soluble polymer, A metal cross-linking agent such as a product, an amino acid and / or a compound of a metal cross-linking agent and an amino acid.

The aqueous pressure-sensitive adhesive base compounded as an essential component in the pressure-sensitive adhesive composition includes at least one selected from the group consisting of polyacrylic acid and / or a salt thereof, carboxymethylcellulose and / or a salt thereof, and gelatin. It is desirable to use some type of aqueous polymeric material. The aqueous pressure-sensitive adhesive base containing these aqueous polymer substances has a high water content after crosslinking, and is excellent in the adhesive strength to the skin.

The aqueous pressure-sensitive adhesive base comprising a crosslinked product of polyacrylic acid and polyacrylate is not particularly limited, and known ones can be used.
Nos. 10614, 59-110616 and 59-11
No. 0617, No. 60-99180, No. 60-2605
No. 12, No. 60-260513, etc., an aqueous adhesive base containing a metal crosslinked product of polyacrylic acid and polyacrylate is preferable.

Specifically, any of the polyacrylic acids of the aqueous pressure-sensitive adhesive base used in the present invention can be used.
There is no particular limitation on the molecular weight and the shape such as straight-chain or branched-chain, but it is preferable to use those having a molecular weight of 10,000 to 10,000,000, and particularly those having a weight-average molecular weight of 10,000 to less than 500,000.
500,000 to less than 2,000,000, when two or more polyacrylic acids having an average molecular weight of 2,000,000 to 4,000,000 are combined,
This is preferable because the feeling of use is improved. In addition to a polymer obtained by polymerizing ordinary acrylic acid, a partially crosslinked acrylic acid polymer such as Carbopol (trade name, manufactured by Goodrich Corporation, USA) can also be suitably used.

Examples of polyacrylates include monovalent metal salts of polyacrylic acid such as sodium polyacrylate and potassium polyacrylate, monoethanolamine polyacrylate, diethanolamine polyacrylate, triethanolamine polyacrylate and the like. One or two of amine salt of polyacrylic acid, ammonium salt of polyacrylic acid, etc.
More than one species may be suitably used.

The mixing ratio (weight ratio) of polyacrylic acid and polyacrylate is preferably 1: 0.1 to 1:10, particularly preferably 1: 1 to 1: 9. An acid or salt partially neutralized so that the polyacrylate has the above ratio may be used. Further, the total blending amount of polyacrylic acid and polyacrylate is preferably 0.5 to 20% by weight of the whole composition (hereinafter, the weight% is simply referred to as%), particularly preferably 1 to 15%. .5
If it is less than 20%, the adhesive strength may be insufficient, and if it exceeds 20%, the viscosity may be high, which may cause a problem in workability during production.

The type of the metal crosslinking agent to be blended as an essential component in the pressure-sensitive adhesive composition of the present invention is not particularly limited as long as it can crosslink the water-soluble polymer substance. Compounds are preferably used. In this case, as the polyvalent metal compound, a magnesium compound, a calcium compound, a zinc compound, a cadmium compound, an aluminum compound, a titanium compound, a tin compound, an iron compound, a chromium compound, a manganese compound, a cobalt compound, a nickel compound, and the like can be used. In consideration of skin safety, it is preferable to use aluminum compounds, magnesium compounds, calcium compounds and the like.

In this case, any of the aluminum compound, magnesium compound and calcium compound can be suitably used, for example, alums such as potassium alum, ammonium alum, iron alum, aluminum hydroxide, aluminum sulfate, aluminum ammonium sulfate, Potassium aluminum sulfate, aluminum chloride, dihydroxy aluminum amino acetate, aluminum acetate, aluminum oxide, synthetic aluminum silicate, aluminum metasilicate, calcium hydroxide, calcium carbonate, calcium sulfate, calcium nitrate, calcium chloride, calcium acetate, calcium oxide, calcium phosphate , Magnesium hydroxide, magnesium carbonate,
Water-soluble compounds such as magnesium sulfate, magnesium acetate, magnesium silicate, magnesium oxide, alumina / magnesium hydroxide, magnesium aluminate metasilicate, magnesium aluminate silicate, synthetic hydrotalcite, double salts containing these metals, etc. One or more of the soluble compounds may be used.

Here, a suitable amount of the metal crosslinking agent varies depending on the kind thereof. For example, when the above-mentioned polyvalent metal compound is used, the amount of the metal crosslinking agent is 0.1% of the whole composition.
001 to 10%, particularly preferably 0.01 to 5%. If it is less than 0.001%, the cohesive strength of the composition may decrease, and if it exceeds 10%, the adhesive strength may decrease.

Further, amino acids to be incorporated as essential components in the pressure-sensitive adhesive composition of the present invention include glycine, alanine, valine, leucine, isoleucine, phenylalanine, tryptophan, cystine, cystine, methionine, proline, hydroxyproline, aspartic acid, Examples include glutamic acid, arginine, histidine, lysine, and derivatives thereof. The amount of the amino acid is 0.001 to 5%, preferably 0.001 to 3%, and most preferably 0.001 to 1% of the whole pressure-sensitive adhesive composition. If the amount is less than 0.001%, the effect of delaying the formation of the crosslinked structure of the aqueous polymer during kneading cannot be sufficiently obtained, and the gel strength of the composition obtained by kneading immediately increases. The step of spreading the pressure-sensitive adhesive composition becomes difficult. Even if the amount of the amino acid is more than 5%, the elasticity and adhesive strength of the crosslinked structure do not change.

The compound of a metal crosslinking agent and an amino acid compounded as an essential component in the pressure-sensitive adhesive composition of the present invention is a salt of an acidic amino acid such as aspartic acid or glutamic acid with the polyvalent metal exemplified as the metal crosslinking agent. Complexes such as dihydroxyaluminum aminoacetate (aluminum glycinate) can be used, and aluminum glycinate is particularly preferred. The compounding amount of the compound of the metal crosslinking agent and the amino acid is 0.001 to 5%, preferably 0.001 to 3%, and most preferably 0.001 to 1% of the whole pressure-sensitive adhesive composition. If it is less than 0.001%, the cohesive strength of the composition may decrease, and if it exceeds 5%, the adhesive strength may decrease.

Further, a cellulose derivative and a polyhydric alcohol may be added to the pressure-sensitive adhesive composition used in the poultice of the present invention as long as the effects of the present invention are not impaired. In this case, any of the cellulose derivatives may be used. For example, one or more of alkali metal salts of carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, methylcellulose and the like may be used. Alkali metal salts of carboxymethylcellulose such as sodium methylcellulose and potassium carboxymethylcellulose can be suitably used. In addition, when adding a cellulose derivative, it is preferable that the compounding quantity is 15% or less of the whole composition. If it exceeds 15%, the viscosity will be high, which may cause a problem in workability during production. Also,
As the polyhydric alcohol, any commonly used one can be used, for example, glycerin, sorbitol, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, polypropylene glycol, 1,3-butylene glycol, 1,3- One or two of propanediol, 1,4-butanediol, maltitol, xylitol, etc.
More than one species may be used. In addition, when adding a polyhydric alcohol, it is preferable that the compounding quantity is 50% or less of the whole composition. If it exceeds 50%, the cohesive force of the aqueous pressure-sensitive adhesive base is reduced, and the aqueous pressure-sensitive adhesive base may remain on the adherend during peeling.

Further, as water-soluble polymer substances of polyacrylic acid, polyacrylate and cellulose derivative, polyvinyl alcohol, polyvinylpyrrolidone, gelatin,
Pectin, vinylpyrrolidone / vinyl acetate copolymer, hydroxypropylcellulose, sodium alginate, xanthan gum, tragacanth and the like can be blended.
When these water-soluble polymers are blended, the blending amount is preferably 0 to 10% of the entire pressure-sensitive adhesive composition. 10
%, The plaster becomes hard, which is a problem when it is manufactured as a patch.

The pressure-sensitive adhesive composition of the present invention is spread particularly on the surface of a support, and is particularly preferably used as a poultice such as a compress, a hot compress, a sheet for heat removal, and a dosage form to be adhered to the skin. For example, it can be applied as a bandage, a skin treatment sheet for improving skin moisture and fine wrinkles, a cosmetic sheet, a patch for treating skin diseases, a transdermal absorption preparation and the like.

In the pressure-sensitive adhesive composition of the present invention, in addition to the above-mentioned essential components which are essential components, raw materials usually used for skin patches such as cataplasms, for example, surfactants, oils, alcohols, humectants , Antioxidants, chelating agents, pH adjusters, ultraviolet absorbers / scatterers, warming agents, fresheners, pharmacologically active substances, inorganic powders, preservatives, emulsifiers, mineral powders, fragrances, pigments, water, etc. Can be added according to the dosage form.

The oils include castor oil, olive oil, cocoa oil, palm oil, camellia oil, coconut oil, wood wax, jojoba oil,
Vegetable oils such as grape seed oil and avocado oil; animal oils such as mink oil and egg yolk oil; waxes such as beeswax, spermaceti, lanolin, carnauba wax, candelilla wax; liquid paraffin, squalane, microcrystalline wax, ceresin Hydrocarbons such as wax, paraffin wax, petrolatum; natural and synthetic fatty acids such as lauric acid, myristic acid, stearic acid, oleic acid, isostearic acid, behenic acid; cetanol, stearyl alcohol, hexyldecanol, octyldodecanol, lauryl alcohol And natural and synthetic higher alcohols such as isopropyl myristate, isopropyl palmitate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate. It can be.

Examples of the humectant include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol and dipropylene glycol; NMF components such as amino acids and sodium pyrrolidone carboxylate; Examples thereof include water-soluble polymers such as acids, collagen, mucopolysaccharides, and chondroitin sulfate.

As antioxidants, dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid and its salts, etc .; as chelating agents, disodium edetate, ethylenediaminetetraacetic acid and its salts, pyrophosphoric acid and its salts, hexametaphosphate And its salts, gluconic acid and its salts, and the like. Examples of the pH adjuster include sodium hydroxide, potassium hydroxide, triethanolamine, aqueous ammonia, boric acid, borax, and potassium hydrogen phosphate. it can.

Examples of the ultraviolet absorbing / scattering agent include 2-hydroxy-4-methoxybenzophenone, octyldimethyl paraaminobenzoate, ethylhexyl paramethoxycinnamate, titanium oxide, kaolin, talc and the like.

As the warming agent, capsaicin and / or
Or, nonylate vanillylamide and the like can be exemplified. In this case, a synthetic product is used as the nonylate vanillylamide. As the capsaicin, a synthetic product, a crude drug extract, or a crude drug powder or a crude drug extract or a crude drug tincture containing capsaicin may be used. In the case of vanillyl amide nonylate, the amount of these components is preferably 0.001 to 0.1% based on the whole composition. In the case of capsaicin, 0.001 to 0.1 for synthetic products and crude drug extracts
%, 0.5 to 10 in crude drug powder containing capsaicin
%, Crude drug extract is preferably 0.01 to 1.0%, and crude drug tincture is preferably 0.1 to 10%.
Improvement of the therapeutic effect by capsaicin and / or nonyl acid vanillylamide is small, and when the amount is more than this amount,
It is not preferable because skin irritation such as redness and itching of the skin occurs. In addition, you may mix | blend and combine a warming feeling imparting agent and a cooling agent. As a cooling agent, 1-menthol, isopulegol, 3,1-menthoxypropane-1,2-diol, 1- (2-hydroxyphenyl) -4- (3-
Nitrophenyl) -1,2,3,6-tetrahydroxypyrimidin-2-one, ethylmenthancarboxamide, p-menthane-3,8-diol, 3,8-dihydroxy-p-menthane-3,9-diol, Examples thereof include trialkyl-substituted cyclohexanecarboxyamide and the like, with l-menthol and isopulegol being particularly preferred. In addition, the optical isomer of the menthol analog is not particularly limited.

The pharmacologically active substance to be added to the pressure-sensitive adhesive composition of the present invention includes, for example, antibiotics, chemotherapeutic agents, bacteriostatic / bactericidal / disinfecting agents, non-steroidal anti-inflammatory agents, steroidal anti-inflammatory agents, Anticancer drug, psychotropic drug, local anesthetic, antiparkinsonian, sex hormone, antiperspirant, sunscreen, antiallergic, antiarrhythmic, antihypertensive, vasodilator, vasodilator, muscle relaxant , Antiemetic, psoriasis treatment,
Emollients, emollients, prostaglandins, fat-soluble vitamins, enzymes, peptide hormones, antidiabetic agents, polysaccharides, plant extracts and essential oils, diagnostic agents, insecticides, insect repellents, dyes And pesticides. Specific examples of these drugs are as follows.

[Antibiotics] Penicillin G, penicillin
V, methicillin, oxacillin, cloxacillin, ann
Picilin, hetacillin, cyclacillin, amoxicillin
Penicillins such as carbenicillin, sulbenicillin, etc.
Antibiotics. Cephaloridin, cephalotin, cefazoli
Cephalosin, cephaloglysin, cephalexin, etc.
Porin antibiotics. Streptomycin, Kanamaishi
, Dibekacin, gentamicin, fradiomycin, etc.
Aminoglucoside antibiotics. Oxytetracycline
, Tetracycline, dimethylchlorotetracycline
, Doxycycline, minocycline, etc.
Clean antibiotics. Erythromycin, Leucomyci
And macrolide antibiotics such as josamycin. Rin
Lincomycin derivatives such as Comycin and Clindamycin
Raw material. Chloramphenicol, Micamycin, Grammy
Cydin, gramicidin S, capreomycin, cyclo
Serine, Enviomycin, Rifampicin, Nysta
Tin, tricomycin, amphotericin B, griseooff
Rubin, variotin, pyrrolenitrin, siccanin,
Nitrofurantoin, 5-iodo-2-deoxyuridine
, Cefamedin, phosphonomycin, N-form
And imidoylchenamycin monohydrate. [Chemotherapeutic agents] mafenide acetate, sulfadiazine,
Rufadiazine silver, sulfamethoxazole sodium
, Sulfisomidine, sulfisomidine sodium, etc.
Topical sulfa drugs. [Bacteriostatic, disinfectant, disinfectant] iodine, pompidone iodine, diyo
Hydroxypropane, benzalkonium chloride, chloride
Benzethonium, methylrosaniline chloride, hexachloro
Phen, chlorhexidine, benzoyl peroxide
And tolnaftate. [Antifungal agent] naphthiomate, clotrimazole,
Theofulvin, Siccanin, Tricomycin, Nysta
Tin, pyrrolnitrin, exalamide, crocona hydrochloride
Sol, isoconazole nitrate, econazole nitrate, nitric acid
Oxyconazole, sulconazole nitrate, miconazo
Thioconazole, tolcyclate, barioten, ha
Loprozin, phenyl iodoundecylate, bifona
Zole, naftifine, ketoconazole, octopiro
Ox, ciclopirox, olamine, etc.
You. [Non-steroidal anti-inflammatory agent] salicylic acid and its salts, a
Salicylic acid derivatives such as spirin, acetaminophen
, Aminopyrine, antipyrine, oxyphenbutazo
, Sulpyrine, indomethacin, diclofenacna
Thorium, ibuprofen, sulindac, naproxe
, Ketoprofen, etofenamate, salicylamine
Do, triethanolamine salicylate, flufenam
Acid and its salts and derivatives, meclofenamic acid and its
Salts and derivatives thereof, colchicine, bufexamac,
Ibufenac, loxoprofen, fenbufen,
Diflunisal, alclofenac, phenylbutazo
, Mefenamic acid and its salts and derivatives, fenop
Lofen, Bendazak, Piroxicam, Flurvipro
Fen, zaltoprofen, etodolac and others
You. [Steroidal anti-inflammatory drug] Amcinoid, valerate pred
Nizolone, diflucortron valerate, beta meta valerate
Dzone, betamethasone acetate, dexamethasone acetate, zip
Betamethasone lopionate, dexamethasone, triam
Sinolone acetonide, rilcinonide, hydrocortizo
Flumethasone pivalate, fluocinonide, fluocin
Norone acetonide, fluotometron, fludroxico
Lutide, prednisolone, clobetasol propionate
, Beclomethasone propionate, betamethasone, meth
Leprednisolone, methylprednisolone acetate,
Hydrocortisone butyrate and the like. [Anti-cancer agent] 5-fluorouracil, 6-mercaptop
Phosphorus, methotrexate, bleomycin, mitomai
Syn-C, Adriamycin, Carbocon, Actinomy
Syn-C, daunorubicin, neocarzinostatin, black
Momycin A, L-asparaginase, picibanil,
Vinplastin, vincristine and the like. [Psychotropic agents] chlorpromazine, reserpine, chlordi
Azepoxide and the like. [Anti-Parkinson's disease agent] L-dopa, chlorzoxazone
And the like. [Sex hormones] estrogen, androgen, est
Ladiol, testosterone, progesterone, etc.
I can do it. [Antiperspirant] propantheline bromide, scopolami
And quaternary acyloxymethyl ammonium salts.
Can be [Sunscreen agent] p-aminobenzoic acid, p-dimethyl
Aminobenzoic acid or their alkyl esters
And so on. [Anti-allergic agent] diproheptadine hydrochloride
, Sodium cromoglycate, ketotifen, etc.
I can do it. [Antiarrhythmic agent] acebutolol, alprenolol, a
Ndenolol, carteolol, bucmorol, buffet
Troll, bupranolol, propranolol, pind
Rolls and the like. [Anti-hypertensive agent] Laurol such as reserpine and resinamine
Fear alkaloids. Clonidine, prazosin, pear
Dihydroergotoxine luate, methicran, methyl dough
And guanethidine, betanidine and the like. [Vasodilators] efloxate, etaphenone, oxy
Fedrin, carbochromene, dilazep, diltiazem
, Trimetazidine, pentaerythritol tetranitrate, di
Pyridamole, isosorbide dinitrate, trapidil, nitro
Glycerin, nifedipine, preniramine, molsidomi
, Phosphate trol nitrate, inositol hexani
Cotinate, isoxsuprine, nylidrin, citric acid
Nicametate, cyclandate, cinnarizine, nico
Chinic alcohol, hepronikart, etc.
You. [Vascular reinforcing agent] Rutin and the like. [Muscle relaxant] Diazepam and the like. [Antimetic] Chlorpromazine and the like. [Therapeutic agent for psoriasis] Methoxsalen and the like. [Emollient or emollient] hydroquinone, urine
Element, heparin, chondroitin sulfate and the like. [Prostaglandins] Prostaglandin F_Twoα,
Prostacyclin, Prostaglandin E₁, Pros
Tag Landin E_Two, 7-Thiaprostaglandin E₁, 1
6,17,18,19,20-pentanor-15-cycl
Lopentyl-7-thiaprostaglandin E ₁, 16,
16-dimethyl-7-thiaprostaglandin E₁, 1
7,20-dimethyl-7-thiaprostaglandin
E₁, 16,17,18,19,20-Pentanol-1
5-cyclohexyl-Δ^Two-7-Tiaprostagland
E₁, 16,16-dimethyl-Δ^Two-7-Tiaprosta
Grangen E₁, 7-fluoroprostacyclin, 5
-Fluoroprostacyclin, 16, 17, 18, 1
9,20-pentanor-15-cyclohexylprosta
Cyclin, 16, 17, 18, 19, 20-pentano
-15-cyclopentyl prostacyclin
I can do it. [Vitamins] 1,25-dihydroxyvitamin D_Three,
1α-hydroxyvitamin D_Three, 1,24-dihydroxy
Shivitamin D_Three, 24,25-dihydroxyvitamin
D_Three1,1α, 25-dihydroxyvitamin D_Three-26,2
3-lactone, 25-hydroxyvitamin D_Three-26,
23-lactone, vitamin A, vitamin E, tokoff acetate
Hellol, vitamin K, vitamin B group, vitamin C, bi
Tamine F, Vitamin P, Vitamin U, Carnitine, Fe
Luluric acid, γ-oryzanol, α-lipoic acid, orotic acid and
And its derivatives. [Enzyme preparations] Trypsin, papain, protease,
Zozyme, streptokinase, plasmin, urokina
, Hyaluronidase, α-chymotrypsin, serati
Opeptidase, bromelain, semi-alkali peptida
And the like. [Peptide hormone] Insulin, angiotensin
Vasopressin, ferripressin, protirelin,
Gonadotropin-releasing hormone, corticotropin, professional
Lactin, somatropin, thyrotropin, luteinizing
Remon, calcitonin, kallikrein, paracillin,
Glucagon, oxytocin, gastrin, secretin,
Serum gonadotropin and the like. [Diabetes treatment] Glibenclamide, gliclazide, etc.
Is mentioned. [Polysaccharides] include heparin, chondroitin sulfate, etc.
It is. [Crude drugs] Capsaicin and powder of crude drugs such as psyllium
Or herbal extract such as pepper extract, and dried psyllium
Herbal medicines such as extracts, herbal extracts such as extracts, assembly extracts
Flu extract, crude drug tincture such as arnica tincture, peppermint oil,
And essential oils such as cinnamon oil. The above medicinal component is 1
Use alone or in combination of two or more
Can be appropriately selected.

When the above-mentioned pharmacologically active substance is incorporated into the pressure-sensitive adhesive composition of the present invention, if the substance is listed in the Japanese Pharmacopoeia or if the appropriate amount is determined by other literatures, the use of the substance is prohibited. It is preferable to mix them in an appropriate amount.
The compounding amount of other substances for which no particularly suitable use amount is determined is 0.0001 to 10%, preferably 0.001 to 5%.
% Is desirable. If it is lower than 0.0001%, the effect as a pharmacologically active substance is not recognized, and even if 10% or more is added, the effect does not change.

The pressure-sensitive adhesive composition of the present invention may contain silicone or liquid paraffin in order to improve the releasability of a plastic film when it is used as a poultice. These compounding amounts are 0.1 to 2 of the whole pressure-sensitive adhesive composition.
0.0%, preferably 0.3 to 10.0%, more preferably 0.5 to 5.0%. 0.1%
In the following, the effect of improving the peeling of the film was not observed, and 20%
In the following, the film slips on the pressure-sensitive adhesive composition and loses its value as a product. In this case, the silicone
It can be used without any problem as a silicone resin or silicone oil. For example, silicone resin, methylphenylpolysiloxane, methylpolysiloxane,
Octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, octamethyltrisiloxane, decamethyltetrasiloxane, polyoxyethylene methylpolysiloxane copolymer, polyoxypropylene methylpolysiloxane Polymer, poly (oxyethyleneoxypropylene) methylpolysiloxane copolymer, methylhydrogenpolysiloxane, tetrahydrotetramethylcyclotetrasiloxane, stearoxymethylpolysiloxane, ethoxymethylpolysiloxane, methylpolysiloxane emulsion, highly polymerized methyl Polysiloxane, trimethylcycloxysilicic acid, and cross-linked methylpolysiloxane can be suitably used. Further, as liquid paraffin, light liquid paraffin and heavy liquid paraffin can be used. These silicones and / or liquid paraffins may be used alone or in combination of two or more. These silicones and / or liquid paraffins are blended in a state of being mixed with other oily components.

As preservatives, aminoethylsulfonic acid, benzoic acid, sodium benzoate, benzyl benzoate, anthracite, liquid phenol, ethanol, sodium edetate, cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, dried sodium sulfate , Agar, dl-camphor, strong sump leather N
(Trade name: Saneigen F.F.I.), citric acid, sodium citrate, chlorocresol, chlorobutanol, gentisic acid ethanolamide, salicylic acid, sodium salicylate, dibutylhydroxytoluene, 2,6-di-t -Butyl-4-methylphenol,
Secept (trade name: manufactured by Seiwa Kasei Co., Ltd.), sorbic acid, potassium sorbate, nitrogen, thymol, dehydroacetic acid, sodium dehydroacetate, 2-naphthol, hinokitiol, sucrose, honey, isobutyl parahydroxybenzoate,
Isopropyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate, propyl paraoxybenzoate, methyl paraoxybenzoate, paraformaldehyde, phenylethyl alcohol, phenol, proxel GXL (trade name: manufactured by Zeneca), benzyl alcohol, boric acid Borax, d-borneol, l-menthol, eucalyptus oil, oxyquinoline sulfate, isopropylmethylphenol, undecylenic acid monoethanolamide, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, alkyldiaminoethyl hydrochloride Glycine solution, chlorhexidine hydrochloride (gluconic acid),
Orthophenylphenol, cresol, chloramine T, chlorxylenol, chlorphenesin, alkylisoquinolinium bromide solution, domiphen bromide, thianthol, trichlorocarbanilide, parachlorphenol,
Halocarban, 2- (2-hydroxy-5-methylphenyl) benzotriazole, hexachlorophen, resorcin, phenoxyethanol and the like can be added.

Examples of the emulsifier include a methyl acrylate / -2-ethylhexyl acrylate copolymer resin emulsion,
Sodium N-acyl-L-glutamate, Atmos 3
00 (trade name: manufactured by Kao Corporation), Amacol CAB (trade name: manufactured by Eikodo), allyl glycidyl ether, ethanol, ethylene glycol monomethyl ether, emamin D500B (trade name: manufactured by Kyoeisha Yushi Kagaku Kogyo), Emarex AC -10 (trade name: manufactured by Nippon Emulsion Co., Ltd.), cetylpyridinium chloride, benzalkonium chloride, alkyldiaminoethyl glycine hydrochloride, Eimulgin C1000 (trade name: manufactured by Henkel Hakusui), octyldodecanol, oleyl alcohol, carrageenan,
Potassium soap, carboxyvinyl polymer, carmellose sodium, reduced lanolin, guar gum, Claude base 25 (trade name: manufactured by Takada Koryo Co., Ltd.), glycerin, highly purified egg yolk lecithin, Sanimal 234NS (trade name: manufactured by Nippon Emulsifier), Sanimaru 235 (same as above), Sanimaru 250
-C (same), Sanimaru 250C (75) (same), Sanimaru 258B2 (same), Sanimaru 258BA (same), Sanimaru 258BA2 (same), Sanimaru 258N (same), Sanimaru 265 (same), Sanimaru 451-KT ( Sanimaru 55-HX (same), Sanimaru 55-LX (same),
Sanimaru DVP (same), Sanimaru K-51 (same), Sanimaru K-51 (75) (same), Sanimaru PCS (same),
Sanimaru SN-155 (same as above), Sanimaru ST-451
(Same as above), beeswax, diisopropanolamine,
Diethylene glycol monobutyl ether, dioctyl sodium sulfosuccinate, self-emulsifying glyceryl monostearate, polyethylene glycol distearate, dicetyl phosphoric acid, sodium dibnate, sucrose fatty acid ester, lipophilic glyceryl monooleate, lipophilic monostearic acid Glycerin, potassium hydroxide, sodium hydroxide, hydrogenated soybean phospholipids, hydrogenated lanolin alcohol, squalene, squalane, stearyl alcohol, stearic acid, potassium stearate, sodium stearate, polyoxyl 40 stearate,
Purified soy lecithin, purified lanolin, purified egg yolk lecithin,
Sorbitan sesquioleate, cetanol, sodium cetyl sulfate, cetostearyl alcohol, cetomacrogol 1000, diethyl sebacate, gelatin, D-sorbitol, sorbol 200 (trade name: manufactured by Toho Chemical Industry Co., Ltd.), sorbol 2242 (same as above), solpol 253
9A (same), Solpol 2500A (same), Solpol 2540A (same), Solpol 2676-S (same), Solpol 2720 (same), Solpol 2721 (same),
Solpol 2850A (same as above), Solpol 2852
(Same), Solpol 2942-S (same), Solpol 2
944-S (same), Solpol 3006-K (same), Solpol 3006A (same), Solpol 3006DB
(Same), Solpol 3008-K (Same), Solpol 3
008A (same), Solpol 3080 (same), Solpol 3269 (same), Solpol 50 (same), Solpol 900A (same), Solpol 900B (same), Solpol AC-2357A (same), Solpol AC-2411
A (same), Solpol AC-2721A (same), Solpol AE102 (same), Solpol M2242 (same),
Solpol SM-100P (same as above), Solpol SM-1
00S (same), Solpol SM-200 (same), Solpol TM2 (same), soybean lecithin, talc, calcium carbonate, medium-chain fatty acid triglyceride, neutral anhydrous sodium sulfate, polyoxyethylene sorbite tetraoleate, dehimulus E (product) Name: Henkel Hakusui), kerosene, Toxanone V1D (trade name: Sanyo Chemical Industries),
Toxanone XK-30 (same as above), dodecylbenzenesulfonic acid, polyoxyethylene glyceryl triisostearate, polyoxyethylene glycerin triisostearate (3EO), triethanolamine, sorbitan trioleate, polyoxyethylene trioleate Sorbitan (20EO), sorbitan tristearate, Nikkor PBC-14 (trade name: manufactured by Nikko Nikko Chemicals), Nikkor wax 220 (same), emulsifier AC2338A (trade name: manufactured by Toho Chemical Industry), New Calgen 1015 (trade name: manufactured by Takemoto Yushi Co., Ltd.), Newcargen 1015-P (same as above), Newcargen 1066
K (the same), New Cargen 1070 (the same), New Cargen 1071 (the same), New Cargen 1500TE1
(Same as above), New Cargen 1585TE1 (Same as above), New Cargen 1616-D1 (Same as above), New Cargen 161
6-D6 (same), Newcargen 1616M (same), Newcargen 165 (same), Newcargen 185-K
4 (the same), New Cargen 1880SB (the same), New Cargen 204 (the same), New Cargen 2119-K
(Same as above), New Cargen CP-120 (same as above), New Cargen EP3 (same as above), New Cargen KH-13
(Same as above), New Cargen KH-15 (Same as above), New Cargen KH-20M (Same as above), New Cargen KH-25
(Same as above), New Cargen KL-13 (same as above), New Cargen KL-20M (same as above), New Cargen KL-26
(Same as above), Newcol NN15 (trade name: manufactured by Nippon Emulsifier Co., Ltd.), Newpol LB-65 (trade name: manufactured by Sanyo Chemical Industries, Ltd.), Heimar 212 (trade name: manufactured by Matsumoto Yushi Seiyaku Co., Ltd.), Heimaru CX-8C (Trade name: manufactured by Matsumoto Yushi Seiyaku Co., Ltd.), Hymal PS-90A (same as above), paraffin, nonionic self-emulsifying wax, hydroxypropylcellulose, propylene glycol, propylene glycol fatty acid ester, pectin, hostafat KW-340
(Trade name: manufactured by Hoechst), polyoxyethylene (2
0) Polyoxypropylene (4) cetyl ether, polyoxyethylene alkyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene oleyl ether, sodium polyoxyethylene oleyl ether phosphate, polyoxyethylene stearyl ether, polyoxyethylene cetyl ether Phosphoric acid, polyoxyethylene cetyl ether, sodium polyoxyethylene cetyl ether phosphate (5EO), polyoxyethylene sorbit beeswax, polyoxyethylene sorbit beeswax (6EO), polyoxyethylene castor oil, polyoxy Ethylene behenyl ether, polyoxyethylene behenyl ether (20EO), polyoxyethylene (160) polyoxypropylene (3
0) glycol, polyoxyethylene lauryl ether, polyoxyethylene lanolin, polysorbate 4
0, polysorbate 60, polysorbate 65, polysorbate 80, macrogol 20000, macrogol 300, macrogol 400, myristyl alcohol,
Isopropyl myristate, octyldodecyl myristate, methyl cellulose, methyl naphthalene, α-monoisostearyl glyceryl ether, sorbitan monooleate, polyethylene glycol monooleate, polyoxyethylene sorbitan monooleate (6E.
O. ), Ethylene glycol monostearate, glyceryl monostearate, sorbitan monostearate,
Propylene glycol monostearate, polyethylene glycol monostearate, polyoxyethylene glycerin monostearate, polyoxyethylene sorbitan monostearate (6EO), sorbitan monopalmitate, polyethylene glycol monolaurate (10EO) monolaurin Acid polyoxyethylene sorbitan (20EO), medicinal soap, coconut fatty acid,
Coconut fatty acid diethanolamide, N-lauroyl-L-
Sodium glutamate, lauromacrogol, lauromacrogol (6EO), lauromacrogol (9
E. FIG. O. ), Egg yolk oil, egg yolk phospholipids, liquid paraffin,
Decaglycerin fatty acid ester, pentaerythritol fatty acid ester, polyoxyethylene alkyl ether,
Polyoxyethylene phytostanol, polyoxyethylene lanolin alcohol / beeswax derivative, polyoxyethylene alkylamine / fatty acid amide, polyoxyethylene alkylphenylformaldehyde condensate, alkyl sulfate, polyoxyethylene alkyl ether sulfate, N-acyl amino acid and Salt, N-acylmethyltaurine salt, polyoxyethylene alkyl ether acetate, alkyl sulfocarboxylate, α-olefin sulfonate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, alkyl ammonium salt, alkyl Benzyl ammonium salt, betaine acetate, imidazolium betaine, lecithin, fatty acid ester, polyhydric alcohol fatty acid ester, alkyl glyceryl ether and fatty acid ester, higher grade Alcohol, hydrocarbons, natural animal and vegetable oils, vitamin derivatives, glycyrrhizinic acid, may be added such as glycyrrhetinic acid and derivatives thereof.

The type of the mineral powder is not particularly limited, and those conventionally used in plasters can be used. Examples of such a mineral powder include kaolin, bentonite, and montmorillonite. , Zinc oxide, titanium oxide, silicic anhydride and the like.
The species can be used alone or in combination of two or more. The blending amount can be appropriately selected, but is usually about 1 to 10%, more preferably 4 to 6% of the whole pressure-sensitive adhesive composition. If the amount is too large, the hardness of the pressure-sensitive adhesive composition may be so high that it cannot be spread.
On the other hand, if the amount is too small, the shape-retaining property of the plaster deteriorates, and the back stain occurs.

The kind of the fragrance is not particularly limited, and those conventionally used as fragrances such as poultices can be used. Examples of such fragrances include anise, angelica, benzoic acid, immortelle, Chamomile, garlic, cardamom, galvanum, caraway, carrot seed, guaiac wood, grapefruit, cypress, sandalwood, cedarwood, juniper, star anise, sage, geranium,
Celery, thyme, tarragon, turpentine, spruce, frankincense,
Violet, pine, parsley, birch, patchouli,
Roses, hyssops, fennel, black pepper, bodaige flowers, myrrh, yarrow, lemon, lemongrass, rosemary, laurel, sycamore, peach, cornflower, eucalyptus, yuzu, lavender and other herbal essential oils or extracts, and other lower alcohols And aldehydes, and these can be used alone or in an appropriate combination of two or more. The blending amount of the fragrance can be appropriately selected, and is usually preferably about 0.0001 to 1% based on the whole pressure-sensitive adhesive composition. If the blending amount is too small, the effect of the blending will not be sufficiently obtained,
If too much, skin irritation may occur.

The type of the pigment is not particularly limited, and pigments conventionally used in plasters can be used. Examples of such pigments include Red No. 2, Red No. 3, and Red No. 102. Red No. 104, Red No. 105, Red No. 106, Red No. 201, Red No. 202, Red No. 203
No., Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214
No., Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225
No., Red No. 226, Red No. 227, Red No. 228, Red No. 230 (1), Red No. 230 (2), Red 231
No., Red No. 232, Red No. 401, Red No. 404, Red No. 405, Red No. 501, Red No. 502, Red No. 503
No. Red No. 504, Red No. 505, Red No. 506, Yellow No. 4, Yellow No. 5, Yellow No. 201, Yellow No. 202 (1), Yellow No. 202 (2), Yellow No. 203, Yellow No. 2
No. 04, Yellow No. 205, Yellow No. 401, Yellow No. 402,
Yellow 403 (1), Yellow 404, Yellow 405,
Yellow No. 406, Yellow No. 407, Green No. 3, Green 201
No., Green No. 202, Green No. 204, Green No. 205, Green No. 401, Green No. 402, Blue No. 1, Blue No. 2, Blue No. 2
No. 01, Blue No. 202, Blue No. 203, Blue No. 204,
Blue No. 205, Blue No. 403, Blue No. 404, Orange 20
No. 1, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402
No. 4, orange No. 403, brown No. 201, purple No. 201, purple No. 401, black No. 401, etc., and these can be used alone or in an appropriate combination of two or more. The amount of the dye can be appropriately selected, but is usually from 0.00005 to the entire pressure-sensitive adhesive composition.
0.1%, particularly about 0.0001 to 0.01%, is preferable, and can impart color to the pressure-sensitive adhesive composition and enhance palatability such as visual comfort. If the amount is too small, the effect of the compounding cannot be sufficiently obtained, and if the amount is too large, the color tone may be too strong. When the pigment is added to the attachment composition, the pigment is dissolved in water, oil, alcohol, or the like, and then kneaded with other components so as to prevent shading and spots of the pigment when the composition is spread. Is preferred.

In the pressure-sensitive adhesive composition of the present invention, the content of water in the composition is 30 to 80%, preferably 35 to 75%.
%, Most preferably 40-70%. If the water content is too low, the absorbability of the medicinal component is inferior, and the feeling of use is lowered. If the water content is too high, the adhesive tends to sag or stain on the back.

The pressure-sensitive adhesive composition of the present invention comprises a solvent comprising an aqueous pressure-sensitive adhesive base, a metal cross-linking agent, an essential component comprising an amino acid and / or a compound of a metal cross-linking agent and an amino acid, and a solvent containing other components including a solvent. Has a gel strength of 2 to 15 at the time of completion of kneading with other components including and at the end of spreading to a support material, and has an elasticity of 50 to 400 g / cm ² , preferably 80 to 300 g after formation of a crosslinked structure. / Cm ² , more preferably 90 to ²
It is characterized by 50 g / cm ² . Here, the gel strength means that about 200 g of a plaster such as an adhesive composition is packed in a bottle having an inner diameter of 50 mm and a depth of 100 mm so that no space is generated, and an acrylic rod having a diameter of 10 mm is loaded with a load of 30 g and a penetration speed of 20 mm. Per minute, the distance x (mm) at which the acrylic rod extended was measured, and calculated by the following formula. Gel strength = 1 × 100 The elasticity was measured by applying a constant stress (336.7 g) to the surface of the cataplasm without the facing with a 0.55 cm diameter measuring adapter.
/ Cm ² ) and allowed to stand, and after 5 minutes the stress when relaxed was measured with a rheometer, and the elasticity (g / c
m ² ).

If the gel strength at the end of kneading and at the end of spreading on the support material is less than 2, bleeding of the adhesive composition at the time of spreading will occur. If the gel strength is greater than 15, the adhesive composition may not be spread evenly due to partially non-uniform cross-linked gelling, or the viscosity may be significantly increased during the spreading step, and the spread may not be uniform. Cause problems. If the elasticity after the formation of the crosslinked structure is smaller than 50 g / cm ² ,
There is a case where back spots of the pressure-sensitive adhesive composition occur. Elasticity is 40
If it is larger than 0 g / cm ² , the pressure-sensitive adhesive composition will have poor tackiness and will not have adequate adhesion to the skin.

The cataplasm according to the present invention is prepared by preparing the above-mentioned pressure-sensitive adhesive composition, applying it to a suitable support such as cotton cloth, synthetic fiber non-woven fabric or plastic film, spreading it to a uniform thickness. It is made by sticking a plastic film or a cotton cloth or a non-woven fabric of synthetic fiber to the cloth. here,
The cut shape and size of the cataplasm are not particularly limited, and may be, for example, a rectangle, a band, or a shape suitable for sticking to the nose or cheek. When using a plastic film, the film material is preferably polyethylene, polyethylene terephthalate, or polypropylene. Also,
These films may be surface-treated with silicone or the like for the purpose of improving the peelability of the plaster at the time of production or use of the cataplasm.

(Embodiments) Preferred embodiments for the pressure-sensitive adhesive composition and poultice of the present invention are described below. (1) The aqueous adhesive base has an average molecular weight of 50 to 200.
The pressure-sensitive adhesive composition according to claim 1, wherein a combination of 10,000 polyacrylic acids and / or salts thereof and polyacrylic acids and / or salts thereof having an average molecular weight of 50,000 to 300,000 is used. Stuff. (2) The pressure-sensitive adhesive composition according to claim 1, wherein the water-based pressure-sensitive adhesive base contains a cellulose derivative and / or a salt thereof having a viscosity of a 1% by weight aqueous solution at 25 ° C of 1,000 to 4000 cps. (3) Any of the pressure-sensitive adhesive compositions containing gelatin as an aqueous pressure-sensitive adhesive base. (4) Any one of the above pulp having an adhesive strength represented by a ball number measured in accordance with JIS Z 0237-1991 of 10 or more, preferably 11 or more, more preferably 15 or more, and most preferably 18 or more. Agent.

[0043]

According to the present invention, it has a moderate adhesive strength,
No discomfort to the skin, excellent usability, less skin irritation, and gel strength at the end of kneading of essential components and other components including solvent and at the end of spreading to the support material. The optimal value, and the elasticity after forming the crosslinked structure is appropriate,
It is possible to provide a pressure-sensitive adhesive composition that appropriately adheres to the skin and a poultice provided with the composition.

[0044]

EXAMPLES The present invention will be described below in detail with reference to Examples and Comparative Examples, but the present invention is not limited to the following Examples. -Experiment 1: Evaluation of adhesive strength of cataplasms Examples 1 to 30 and Comparative Examples 1 to 1 shown in Tables 1 to 5
The adhesive composition of each composition described in 5 was kneaded for 30 minutes, spread on a nonwoven fabric to a certain thickness by a spreader, covered with a polyethylene film, and cut into a certain area. A cataplasm was obtained. The adhesive strength and workability of each cataplasm were examined. Adhesive strength is JISZ 0
It was measured according to 237-1991. That is, JIS
Using the ball rolling device used in Z 0237-1980, the ball number is defined as a ball number with a value of 32 times the JIS B 1501 "call of ball" using a material specified in JIS G4805 under a condition of an inclination angle of 30 degrees. When the rolled ball was rolled, it was represented by the largest ball number among the balls that stopped completely in the measuring section. The workability was represented by を when the pressure-sensitive adhesive composition was uniformly spread on the nonwoven fabric or film at the time of spreading, and × when the pressure-sensitive adhesive composition was not uniformly spreadable. The results are shown in Tables 1 to 5.

[Table 1]

[Table 2]

[Table 3]

[Table 4]

[Table 5]

As shown in Tables 1 to 5, the poultices of Examples 1 to 30 according to the present invention had adhesive strengths represented by ball numbers of 17 to 24, which were significantly higher than those of Comparative Examples 1 to 5. Has become. The workability of Examples 1 to 30 was all good.

Experiment 2: Gel strength and elasticity of pressure-sensitive adhesive composition The composition shown in Example 1 in Table 1 and Comparative Example 1 in Table 5
And a composition (Comparative Example 6) containing only the metal crosslinking agent without adding glycine (increase in purified water) in the composition of Example 2 in Table 1 The pressure-sensitive adhesive composition having the composition was kneaded for 30 minutes, and immediately after that, the gel strength (referred to as T1 gel strength) was measured. After kneading, the gel strength (referred to as T2 gel strength) at the time (after 240 minutes) when the actual spreading and cutting were completed was measured. Furthermore, the elasticity after 30 days corresponding to the time of shipping the cataplasm (T3 elasticity)
Was measured. As described above, the gel strength is such that about 200 g of a plaster such as an adhesive composition has an inner diameter of 50 mm and a depth of 10 g.
Packed in a 0 mm bottle so that no space is created, and a diameter of 10 mm
Was stretched at a load of 30 g and an extension speed of 20 mm / min, and the distance x (mm) at which the acrylic rod was extended was measured and calculated by the following equation. Gel strength (mm) = 1 ÷ x × 100 The elasticity is measured by applying a constant stress (336.7 g) to the surface of the cataplasm without the facing with a measuring adapter having a diameter of 0.55 cm.
/ Cm ² ) was added and left to stand. After 5 minutes, the stress at the time of relaxation was measured with a rheometer, and the elasticity (g / c) of the cataplasm was measured.
m ² ).

[0047]

As is clear from the results, the adhesive composition of Example 1 according to the present invention has a moderate gel strength of 2 to 10 after kneading (T1), and after spreading and cutting (T2). Gel strength and elasticity (T3) after 30 days is 150 g / cm ²
And elasticity showing moderate skin adhesion. On the other hand, in Comparative Example 1 containing no metal crosslinking agent and no amino acid, the gel strength did not increase after kneading, and back stains occurred. In Comparative Example 6, which did not contain an amino acid, the pressure-sensitive adhesive composition could not be spread uniformly due to partially non-uniform cross-linked gelation, or the viscosity was significantly increased during the spreading step, and the spread was uniform. could not.

Claims (2)

[Claims] 1. An aqueous pressure-sensitive adhesive base containing a water-soluble polymer substance, a metal cross-linking agent for forming a cross-linked structure of the water-soluble polymer substance, an amino acid and / or a compound of a metal cross-linking agent and an amino acid are essential. As a component, the gel strength at the time of completion of kneading of the above essential component and other components including a solvent and at the time of completion of spreading to a support material is 2 to 15, and the elasticity after forming a crosslinked structure is 50. An adhesive composition having a weight of from 400 g / cm ² to 400 g / cm ² . 2. A poultice prepared by spreading the pressure-sensitive adhesive composition according to claim 1 on a support material.