JPH10500978A - p53タンパク質の調節による腫瘍の治療方法 - Google Patents
p53タンパク質の調節による腫瘍の治療方法Info
- Publication number
- JPH10500978A JPH10500978A JP8500420A JP50042096A JPH10500978A JP H10500978 A JPH10500978 A JP H10500978A JP 8500420 A JP8500420 A JP 8500420A JP 50042096 A JP50042096 A JP 50042096A JP H10500978 A JPH10500978 A JP H10500978A
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- protein
- nucleic acid
- calpain
- vector
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- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 229940102223 injectable solution Drugs 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 210000003292 kidney cell Anatomy 0.000 description 1
- 210000004962 mammalian cell Anatomy 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000011278 mitosis Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 238000010369 molecular cloning Methods 0.000 description 1
- 208000008813 mosaic variegated aneuploidy syndrome Diseases 0.000 description 1
- 108010068164 mu-calpain Proteins 0.000 description 1
- 238000002703 mutagenesis Methods 0.000 description 1
- 231100000350 mutagenesis Toxicity 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 208000025402 neoplasm of esophagus Diseases 0.000 description 1
- 210000000633 nuclear envelope Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 231100000590 oncogenic Toxicity 0.000 description 1
- 108091008819 oncoproteins Proteins 0.000 description 1
- 102000027450 oncoproteins Human genes 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000004481 post-translational protein modification Effects 0.000 description 1
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 1
- 230000005522 programmed cell death Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 238000000751 protein extraction Methods 0.000 description 1
- 239000012460 protein solution Substances 0.000 description 1
- 230000006798 recombination Effects 0.000 description 1
- 238000005215 recombination Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 238000001890 transfection Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000013519 translation Methods 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000002753 trypsin inhibitor Substances 0.000 description 1
- 230000005751 tumor progression Effects 0.000 description 1
- 230000037455 tumor specific immune response Effects 0.000 description 1
- 231100000588 tumorigenic Toxicity 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 230000006648 viral gene expression Effects 0.000 description 1
- 210000002845 virion Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8139—Cysteine protease (E.C. 3.4.22) inhibitors, e.g. cystatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR94/06583 | 1994-05-31 | ||
FR9406583A FR2720277B1 (fr) | 1994-05-31 | 1994-05-31 | Méthode de traitement des cancers par régulation de la protéine P53. |
PCT/FR1995/000670 WO1995033060A1 (fr) | 1994-05-31 | 1995-05-22 | Methode de traitement des cancers par regulation de la proteine p53 |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH10500978A true JPH10500978A (ja) | 1998-01-27 |
Family
ID=9463670
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8500420A Pending JPH10500978A (ja) | 1994-05-31 | 1995-05-22 | p53タンパク質の調節による腫瘍の治療方法 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0763121A1 (fi) |
JP (1) | JPH10500978A (fi) |
AU (1) | AU714209B2 (fi) |
CA (1) | CA2190293C (fi) |
FI (1) | FI120501B (fi) |
FR (1) | FR2720277B1 (fi) |
NO (1) | NO321411B1 (fi) |
WO (1) | WO1995033060A1 (fi) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19518488C1 (de) * | 1995-05-19 | 1996-10-10 | Progen Biotechnik Gmbh | Autoantigen, geeignet zur Feststellung einer Thromboseneigung |
EP0799892A3 (en) * | 1996-04-05 | 1998-08-12 | Takeda Chemical Industries, Ltd. | Calpain, its production and use |
US6232454B1 (en) | 1998-02-27 | 2001-05-15 | Incyte Genomics, Inc. | Human proteinase molecules |
AU2344100A (en) * | 1998-11-18 | 2000-06-05 | Canji, Inc. | Viral vectors with late transgene expression |
AU2001247922A1 (en) * | 2000-03-31 | 2001-10-15 | Parker Hughes Institute | Calpain inhibitors in cancer treatment |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0753665B2 (ja) * | 1984-04-20 | 1995-06-07 | 財団法人癌研究会 | 抗転移剤 |
US5340922B1 (en) * | 1988-05-31 | 1999-11-02 | Mclean Hospital Corp | Neural calcium-activated neutral proteinase inhibitors |
EP0395309B1 (en) * | 1989-04-28 | 1995-12-27 | Takara Shuzo Co. Ltd. | Human calpastatin-like polypeptide |
JPH0641067A (ja) * | 1992-04-20 | 1994-02-15 | Kitasato Inst:The | 新規カルパイン阻害物質kp−1241及びその製造法 |
EP0580161A1 (en) * | 1992-07-22 | 1994-01-26 | THE McLEAN HOSPITAL CORPORATION | Prophylactic and therapeutic treatment of Alzheimer's disease |
US5607831A (en) * | 1993-03-25 | 1997-03-04 | The United States Of America As Represented By The Department Of Health And Human Services | In vitro methods for assessing the susceptibility of HIV-1-infected individuals to cysteine protease-mediated activation-induced programmed cell death |
-
1994
- 1994-05-31 FR FR9406583A patent/FR2720277B1/fr not_active Expired - Lifetime
-
1995
- 1995-05-22 AU AU26206/95A patent/AU714209B2/en not_active Ceased
- 1995-05-22 JP JP8500420A patent/JPH10500978A/ja active Pending
- 1995-05-22 EP EP95920973A patent/EP0763121A1/fr not_active Withdrawn
- 1995-05-22 WO PCT/FR1995/000670 patent/WO1995033060A1/fr not_active Application Discontinuation
- 1995-05-22 CA CA2190293A patent/CA2190293C/fr not_active Expired - Fee Related
-
1996
- 1996-11-11 NO NO19964772A patent/NO321411B1/no not_active IP Right Cessation
- 1996-11-29 FI FI964783A patent/FI120501B/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI120501B (fi) | 2009-11-13 |
FI964783A0 (fi) | 1996-11-29 |
FR2720277A1 (fr) | 1995-12-01 |
EP0763121A1 (fr) | 1997-03-19 |
CA2190293C (fr) | 2011-06-28 |
AU714209B2 (en) | 1999-12-23 |
WO1995033060A1 (fr) | 1995-12-07 |
CA2190293A1 (fr) | 1995-12-07 |
NO321411B1 (no) | 2006-05-08 |
FI964783L (fi) | 1996-11-29 |
FR2720277B1 (fr) | 1996-07-12 |
NO964772L (no) | 1996-11-11 |
NO964772D0 (no) | 1996-11-11 |
AU2620695A (en) | 1995-12-21 |
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