JPH06256140A - Beautifying cosmetic - Google Patents

Abstract

PURPOSE:To provide a beautifying cosmetic having erythema-suppressive effect due to ultraviolet light radiation and beautifying effect, also high in safety to the skin and preservation stability. CONSTITUTION:The beautifying cosmetic formulated with (A) at least one kind selected from glycyrrhizic acid derivatives and salts thereof or glycyrrhetic acid derivatives and salts thereof and (B) a water-soluble ultraviolet light absorber.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a whitening cosmetic composition which has an excellent effect of suppressing inflammation (suppressing erythema of ultraviolet rays) and a whitening effect on skin exposed to ultraviolet rays, has excellent skin safety, and has high storage stability. .

[0002]

2. Description of the Related Art UV rays cause inflammation (erythema) on the skin and release various factors to stimulate melanocytes. As a result, the color tone changes and blackens. This blackening is caused by the overproduction of melanin produced in melanocytes and delivered to epidermal cells, and melanin is produced by the oxidation of tyrosine.

Conventionally, in order to prevent blackening, stains and freckles of the skin and maintain the original white skin, vitamin C salts and fatty acid derivatives which prevent this oxidation, hydroquinone monobenzyl ether, hydrogen peroxide and the like are blended. Skin cosmetics have been proposed.

However, when a vitamin C derivative is added to these whitening cosmetics, the storage stability is insufficient, or the anti-inflammatory and whitening effects due to ultraviolet rays are often not sufficiently observed. On the other hand, blending hydroquinone monobenzyl ether or the like into a whitening cosmetic has the effect of lightening dark skin, but has the drawback of causing a problem in terms of skin safety.

It has been confirmed that when a glycyrrhizic acid derivative and its salt and a glycyrrhetinic acid derivative and its salt are mixed alone, they have antibacterial action, anti-inflammatory action and antiallergic action. However, its anti-inflammatory effect and whitening effect were not satisfactory.

On the other hand, the water-soluble ultraviolet absorber has an effect of suppressing inflammation caused by ultraviolet rays due to its ultraviolet absorbing effect, but has no whitening effect and is insufficient in storage stability.

As described above, it is extremely difficult to obtain a storage-stable skin cosmetic having an excellent anti-inflammatory effect (suppressing erythema of ultraviolet rays) and a whitening effect and having high skin safety. As a result of intensive studies in view of such circumstances, the present inventors have found that the whitening cosmetic composition described below has an effect of suppressing inflammation and whitening by ultraviolet rays, and also has excellent skin safety and storage stability. The present invention has been completed and the present invention has been completed.

That is, an object of the present invention is to provide a whitening cosmetic composition which has an effect of suppressing inflammation caused by ultraviolet rays and a whitening effect, and which is excellent in skin safety and storage stability.

[0009]

Means for Solving the Problems The above-mentioned object is to provide a whitening cosmetic characterized in that it contains at least one selected from glycyrrhizic acid derivatives and salts thereof or glycyrrhetinic acid derivatives and salts thereof, and a water-soluble ultraviolet absorber. To be achieved.

The glycyrrhizic acid derivative and its salt used in the present invention are known compounds, and examples of the glycyrrhizinic acid derivative include 18α-glycyrrhizinic acid (abbreviated as α-Gi) and 18β-glycyrrhizinic acid (abbreviated as β-Gi). Examples of the esters of glycyrrhizinic acid derivatives include 18α-glycyrrhizinic acid methyl ester (abbreviated as α-Gi methyl), 18β-glycyrrhizinic acid methyl ester (abbreviated as β-Gimethyl), and salts of glycyrrhizinic acid derivatives. Examples are trisodium 18α-glycyrrhizinate (abbreviated as α-Gi-Na3), monopotassium 18α-glycyrrhizinate (α-G
i-K), 18α-glycyrrhizinate dipotassium (abbreviated as α-Gi-K2), 18α-glycyrrhizinate monoammonium (abbreviated as α-Gi-NH3), 18β-trisodium glycyrrhizinate (β-).
Gi-Na3), 18β-glycyrrhizinate monopotassium (abbreviated as β-Gi-K), 18β-glycyrrhizinate dipotassium (abbreviated as β-Gi-K2), 18β-glycyrrhizinate monoammonium (β).
-Gi-NH3) and the like can be mentioned as particularly preferable ones, but the present invention is not limited thereto.

The glycyrrhetinic acid derivative and its salt used in the present invention are known compounds, and the glycyrrhetinic acid derivative is α-glycyrrhetinic acid (α-Ge).
And β-glycyrrhetinic acid (abbreviated as β-Ge) and esters of glycyrrhetinic acid derivatives as stearyl α-glycyrrhetinic acid (abbreviated as α-Ge-stearyl) and β-glycyrrhetinic acid stearyl (β). -Ge-stearyl), α-glycyrrhetinic acid pyridoxine (abbreviated as α-Ge-pyridoxine), β-glycyrrhetinic acid pyridoxine (β-Ge-).
Pyridoxine), α-glycyrrhetinic acid glycerin (abbreviated as α-Ge-glycerin), β-glycyrrhetinic acid glycerin (abbreviated as β-Ge-glycerin), and salts of glycyrrhetinic acid derivatives include 3-succinyloxy. Disodium glycyrrhetinate (abbreviated as 3-succinyl-Ge-Na2) and the like can be mentioned as particularly preferable ones, but the present invention is not limited thereto.

As the water-soluble ultraviolet absorber used in the present invention, para-aminobenzoic acid, para-methoxycinnamic acid, 2
-Phenylbenzimidazole-5-sulfonic acid, alkali metal salts of salicylic acid derivatives, ammonia or salts of organic amines, but not limited to these. These water-soluble ultraviolet absorbers are used alone or in combination of two or more.

The content of the glycyrrhizic acid derivative and its salt or the content of the glycyrrhetinic acid derivative and its salt is 0.005 to 2.0 based on the total amount of the whitening cosmetic composition of the present invention.
% By weight, preferably in the range of 0.05 to 1.0% by weight. If it is less than 0.005% by weight, the effect is not exhibited, and if it exceeds 2.0% by weight, the storage stability of the product is deteriorated, which is not preferable.

The amount of the water-soluble ultraviolet absorber used in the present invention in the cosmetic is 0.00 as the total amount of the cosmetic.
1 to 20% by weight is preferable, and more preferably 0.01 to
It is 10% by weight. If it is less than 0.001% by weight, it is difficult to obtain a whitening effect, and if it exceeds 20% by weight, it is not possible to expect an improvement in the effect commensurate with the effect, and the feeling during use tends to be poor, and individual dosage forms are retained. It will be difficult.

In the cosmetics of the present invention, in addition to the above-mentioned raw materials, tar-based pigments, coloring pigments such as iron oxide, preservatives such as parabens, fatty acid soaps, anionic surfactants such as sodium cetyl sulfate, and polyoxyethylene. Nonionic surfactants such as alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene polyhydric alcohol fatty acid ester, polyoxyethylene hydrogenated castor oil, polyhydric alcohol fatty acid ester, polyglycerin fatty acid ester, tetraalkylammonium salt, etc. Cationic surfactants, betaine-type, sulfobetaine-type, sulfoamino acid-type, amphoteric surfactants such as sodium N-stearoyl-L-glutamate, natural surfactants such as lecithin and lysophosphatidylcholine, oxidation Pigments such as titanium, dibutyl And antioxidants such as mud carboxymethyl toluene, may be appropriately blended within the range to achieve the object of the present invention.

The dosage form of the cosmetic of the present invention includes creams, emulsions, lotions, packs and the like. For example, in the case of an emulsion or the like, this cosmetic can be produced by an ordinary method of emulsifying and dispersing an oily phase and an aqueous phase, which are dissolved by heating, and cooling.

[0017]

EXAMPLES The present invention will be described in detail below based on examples and comparative examples. In addition,% shown in the examples is% by weight. (1) Storage stability test method, (2) Skin color lightness recovery test method, (3) Whitening practical test, (4) UV erythema inhibition test, and (5) Photopatch test described in Examples are as follows. is there.

(1) Storage stability test method The sample was placed in a constant temperature bath at 45 ° C. and observed over time, and evaluated according to the following criteria.

[0019]

[Table 1]

Here, the term "abnormal" means a phenomenon in which discoloration or odor occurs, precipitation occurs in lotion, and phase separation occurs in an emulsion.

(2) Skin color lightness recovery test method The back skin of 20 subjects was irradiated with ultraviolet rays in the UV-B region at twice the minimum erythema dose, and a sample application site and a non-application site were set for each skin. The standard brightness (V0 value, V0 'value) was measured. Subsequently, the sample was applied to the application site twice a day for 4 weeks continuously, and the lightness (Vn value, Vn 'value) of the application site and non-application site was measured after 1, 2 and 4 weeks.
The recovery of skin color was evaluated according to the following criteria.
The lightness of skin (V value of Munsell color system) was calculated from X, Y, and Z values obtained by measurement with a high-speed spectrocolorimeter. The evaluation was shown by the average value of the evaluation points of 20 subjects after 4 weeks.

[0022]

[Table 2]

(3) Practical whitening test Left forearm flexion side part of the forearm flexion side skin of 20 test subjects exposed to sunlight in summer for 3 hours (1.5 hours a day for 2 days) Samples on the skin from the day of exposure to sunlight
The base was applied to the right forearm flexion side skin once a day in the morning and continuously for 13 weeks from the day of exposure to sunlight. The evaluation was shown by the number of test subjects whose effect of the sample applying section was confirmed by the base applying section.

(4) UV Erythema Suppression Test U was applied to the dorsal skin of 10 Hartley guinea pigs from which hair had been removed.
Irradiation with two times the minimum erythema dose of ultraviolet rays in the VB region is performed at two locations each. The sample was applied 24 hours before and immediately after irradiation, the sample application site and the base application site were set, and 24 hours later, the erythema state was evaluated according to the following criteria.

[0025]

[Table 3]

(5) Optical patch test After subjecting 25 subjects' forearm flexion side skin to a closed patch for 24 hours using a patch plate having a diameter of 1.0 cm in which 0.05 g of the sample was applied, the sunlight in summer was exposed. 6 hours (3 a day
For 2 days).

The evaluation was performed by subject 2 according to the following criteria.
The skin condition of 5 persons was evaluated and judged. Judgment result is irradiation 2
After 4 hours, the number of people was (±) or more.

[0028]

[Table 4]

Examples 1 to 5, Comparative Examples 1 to 5 Glycyrrhizic acid derivatives and salts thereof, glycyrrhetinic acid derivatives and salts thereof and water-soluble UV absorbers were blended in the composition shown in Table 5, and skin was prepared according to the following preparation method. A cream was prepared.

Composition

[Table 5]

Preparation method The oil-soluble component of (B) was added to (A) and the temperature was adjusted to 70 ° C., (B)
The water-soluble component of (C) is added to (C) to be uniformly dissolved at 50 ° C, (A) is added to (A) while stirring to emulsify and disperse, and then the temperature is set to 30 ° C while stirring. Cool to prepare. Perform the above-mentioned tests using these as samples,
The results are shown in Tables 6, 7, and 8.

[0032]

[Table 6]

[0033]

[Table 7]

[0034]

[Table 8]

Characteristics The skin creams of Examples 1 to 5 of the present invention were found to have remarkable effects in various characteristics. On the other hand, the skin creams of Comparative Examples 1 to 5 were inferior in various properties as compared with the examples of the present invention.

Example 6 [Skin lotion] The skin lotion of the present invention having the composition shown in Table 9 was prepared by the following production method.

Composition

[Table 9]

Preparation method (A), (B) components are mixed and dissolved, and (B)
Was added to (A) and mixed and stirred to prepare.

Properties The skin lotion of this Example 6 showed good results in all the above tests.

[0040]

Industrial Applicability As described above, it is apparent that the present invention provides a whitening cosmetic composition having an excellent whitening effect, excellent skin safety and high storage stability.

Claims (1)

[Claims] 1. A whitening cosmetic, comprising at least one selected from the group of glycyrrhizic acid derivatives and salts thereof or glycyrrhetinic acid derivatives and salts thereof, and a water-soluble ultraviolet absorber.