JPH04346911A - Cosmetic - Google Patents

Abstract

PURPOSE:To provide a new cosmetic such as beauty water, creams, milky lotions, shampoos, foundations, lip creams or lip sticks containing the water-soluble extract of a Saxifragaceae plant as an active ingredient, having good whitening action and anti-inflammatory action. CONSTITUTION:A new highly safe cosmetic contains a water-soluble extract obtained by extracting a Saxifragaceae plant such as Saxifragastolonifera Meerb., Rodgersia podopyhlla A. gray, Chysosplenium stamineum Franch., Tiarella polyphylla Don, Hydrangeamacrophylla Seringe var.otaksa Makino or Deutzia uniflora Shirai with a water-soluble solvent such as water, alcohol or acetone and has both a high beautifying action and a high anti-inflammatory action. The water-soluble extract of the Saxifragaceae plant is preferably used in an amount of 0.1-5.0wt.% based on the whole amount of the cosmetic as a solid content obtained by distilling off the solvent.

Description

[Detailed description of the invention]

0001

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a new cosmetic composition. More specifically, the present invention relates to a cosmetic containing a water-soluble extract of a plant of the Yukinoshita family as an active ingredient and having whitening and anti-inflammatory effects.

0002

[Prior Art] Although the mechanism by which skin spots and freckles occur is unclear, in general, melanin pigments are formed due to hormonal abnormalities or stimulation of ultraviolet rays from sunlight, and this is caused within the skin. It is thought that it is abnormally deposited in To treat such age spots and freckles, substances that inhibit tyrosinase activity in the skin and suppress melanin production, such as large doses of vitamin C, and glutathione in ointments, creams, and lotions, etc. Methods such as making it into a form and applying it locally are used. Additionally, hydroquinone preparations are used as pharmaceuticals in Europe and America.

[0003] On the other hand, the skin is inflamed due to various skin irritations, such as the action of ultraviolet rays, and anti-inflammatory agents are used to suppress these inflammations. plant extract, glycyrrhizin,
Zinc white etc. are used.

[0004] Furthermore, a decrease in water content from the stratum corneum of the skin causes rough skin. Glycerin, 1,3-butylene glycol, propylene glycol, hyaluronic acid, and the like are used as humectants to provide the stratum corneum with an appropriate moisture content.

[0005]

[Problem to be solved by the invention] Vitamin C
It has poor stability against light over time and causes discoloration and odor, especially in systems containing water. On the other hand, the use of hydroquinone is restricted due to safety issues such as skin irritation and allergy. In addition, it is susceptible to air oxidation, which poses a problem in terms of stability. Thiol compounds such as glutathione and cysteine have a strong off-flavor, are easily oxidized, and have slow effects. Furthermore, 2-mercaptoethylamine salt, N-(2-mercaptoethyl)dimethylamine salt, etc. are known to bleach the skin of black guinea pigs, but they are not commonly used because they tend to cause white spots after bleaching. do not have.

On the other hand, as mentioned above, there are various ingredients that have whitening and anti-inflammatory effects, but in order to produce cosmetics that have both of these effects, it is necessary to add each of these ingredients. However, there are many points that must be kept in mind, such as product stability.

In view of this situation, the present inventors have conducted intensive research and found that a cosmetic containing a water-soluble extract of a plant in the Yukinoshita family as an active ingredient has good whitening and anti-inflammatory effects. The present invention has been completed based on this discovery.

[0008]

[Means for Solving the Problems] The present invention is a cosmetic containing a water-soluble extract of a plant of the Yukinoshita family as an active ingredient.

[0009] The plant of the Yukinoshita family used in the present invention is Saxifragastolonife.
ra Meerb. ), Cornflower (Rodger
sia podopyhlla A. Gray),
Chysosplenium sta
mineum Franch. ), Zudayakushiyu (T
iarella polyphylla Don)
, Hydrangea (Hydrangea macrophyll)
a Seringe var. otaksa M
akino), Deutzia uni (Deutzia uni)
flora Shirai) and other plants. (Illustrated encyclopedia of primary color Makino plants, written by Tomitaro Makino, Hokuryukan)

The water-soluble solvent used in the present invention is water or a solvent soluble in water, such as water, alcohols (methanol, ethanol, 1,3-butylene glycol, propylene glycol, etc.), acetone, etc. Can be mentioned. Furthermore, the plant of the present invention may be extracted using one or a mixed solvent of two or more of these water-soluble solvents. Further, it may be extracted by heating or extracted at room temperature. as needed,
It can be concentrated or diluted and used as a cosmetic raw material.

The cosmetic of the present invention may contain oils and fats within the range that does not impair the effects of the water-soluble extract of plants of the Yukinoshita family.
Waxes, hydrocarbons, fatty acids, alcohols, esters, metal soaps, surfactants, and the like can be blended as raw materials.

Cosmetics produced using these base materials as raw materials include, for example, lotions, creams, milky lotions, shampoos, foundations, lip balms, and lipsticks.

[0013] The amount of the water-soluble extract of the Yukinoshita family plant used in the cosmetic of the present invention is 0.01 to 10% by weight based on the entire cosmetic as a solid content obtained by distilling off the solvent. %, preferably 0.1 to 5.0% by weight. If it is less than 0.01% by weight, no sufficient effect can be expected, and if it exceeds 10% by weight, the effect will not be enhanced and it is uneconomical.

[0014] Furthermore, the method of addition may be either added in advance or added during production, and may be selected as appropriate in consideration of workability.

[0015]

[Examples] The present invention will be explained in more detail with reference to Examples below, but the present invention is not limited to these in any way. In addition, the part shown in an Example shows a weight part, and % shows a weight%.

Example-1 100g of dried saxifrage was shredded and 1000ml of water was added.
The extract was heated and extracted twice for 2 hours each time, and further concentrated by vacuum freeze-drying to obtain 20 g of an extract (containing 99% or more solids).

Example-2 100 g of dried hydrangea was ground, heated and extracted with 1000 ml of a water-ethanol mixture (1:1) for 5 hours, and further concentrated to yield 30 g of extract (containing 50% solids). I got it.

Example 3 100 g of dried Saxifrage was ground and mixed with 1 ethanol of ethanol.
Add 000ml and leave it at room temperature for one month. Further concentration yielded 23 g of extract (containing more than 99% solids).

Example 4 100 g of dried cornflower was crushed, heated and extracted twice with 1000 ml of propanol for 2 hours each time, and further concentrated to obtain 25 g of extract (containing 70% solids).
I got it.

Example 5 Lotion (1) Hot water extract of cornflower (99% as solid)
5.0 parts (2) Glycerin
2.0(3) Ethyl alcohol

7.0(4) Methyl paraoxybenzoate
0.05(5) Polyoxyoxyethylene (20) Lauryl ether
0.5 (6) citric acid

0.01(7) Sodium citrate
0.1 (8) Fragrance
0
．． 1(9) Mix and dissolve components (2) to (4) and (8) to make the total amount 100% with purified water. Separately, components (1), (5) to (7), and (9) are mixed and dissolved. Then, both are mixed and filtered through Tetron cloth (300 mesh) to obtain a product.

Example 6 Cream (1) Hot water extract of Saxifrage (99% as solid)
Part 2.0 (2) Squalane

5.5(3) Olive oil
3
．． 0(4) Stearic acid
2.0 (5) Beeswax
2.0(6) Octyldodecyl myristate 3.5(7)
Polyoxyethylene (20) Cetyl ether
3.0(8) Behenyl alcohol
1.5(9) Glycerin monostearate
2.5(10)1,3
-Butylene glycol 8
．． 5(11) Methyl paraoxybenzoate
0.2(12) Ethyl paraoxybenzoate 0.05(1
3) Fragrance
0.1 (14) Components (2) to (9) made to a total volume of 100 with purified water are dissolved and mixed by heating, and the mixture is kept at 70°C to form an oil phase. Ingredients (1), (
10) to (12) are heated and dissolved in component (14), mixed, and kept at 75°C to form an aqueous phase. Add the aqueous phase to the oil phase to emulsify, add component (13), and cool to 30°C while stirring to obtain a product.

Example 7 Emulsion (1) Ethanol extract of Saxifrage (99% as solid content)
1.0 part (2) Squalane
5.0 (3) Olive oil

5.0 (4) Jojoba oil

5.0(5) Cetyl alcohol
1.5(6) Glycerin monostearate
2.0 (7) Polyoxyethylene (20) Cetyl ether
3.0 (8) Polyoxyethylene (20) Sorbitan Monooleate
2.0(9) Dipropylene glycol
1.0 (10) Glycerin
2.0(
11) Fragrance
0.1 (12)
Methyl paraoxybenzoate
0.2 (13) Make the total amount 100 with purified water. Components (2) to (8) are dissolved and mixed by heating, and the mixture is kept at 70°C to form an oil phase. Components (1), (9), (10), (1
2) is heated and dissolved in component (13), mixed, and kept at 75°C to form an aqueous phase. Add the aqueous phase to the oil phase and emulsify and disperse the ingredients (
Add 11) and cool to 30°C while stirring to form a product.

Example-8 Pack (1) Cornflower propylene glycol
Extract (20% as solids)
3.0 parts (2) Polyvinyl alcohol
11.5 (
3) 1,3-butylene glycol
2.5 (4) polyoxyethylene (4
0) Hydrogenated castor oil
1.0 (5)
Ethyl alcohol
7.0(6) Methyl paraoxybenzoate 0
．． 2(7) Fragrance
0.0
5(8) Dissolve components (1) to (8) to a total volume of 100 with purified water at 75°C, and dissolve at 30°C.
Cool it until it becomes a product.

[0024]

[Effects of the Invention] The cosmetic composition of the present invention containing a water-soluble extract of a plant belonging to the Yukinoshita family as an active ingredient has highly stable whitening and anti-inflammatory effects, and is also preferable in terms of safety. be. Hereinafter, the effects of the present invention will be explained by giving experimental examples.

[Experimental Example] Efficacy Test Example 1 In order to investigate the whitening effect and tyrosinase activity inhibition effect, 0.0
The tyrosinase activity inhibition power of the 5% aqueous solution was measured before and after incubation at 37°C for 2 weeks. As comparative examples, ascorbic acid, loofah water, and a hot water extract of loofah fruit, which have been conventionally used as cosmetics, were similarly tested. Note that the extract obtained in Example 1 was used as the sample. In addition, as a method for preparing a loofah hot water extract (comparative example), 10 g of the dried product was extracted with hot water (95°C, 3 hours, 300
ml), the filtrate was lyophilized in vacuo.

Measurement of tyrosinase activity inhibition; In a test tube, add 1 ml of L-tyrosine solution (0.3 mg/ml), 1 ml of Max Bain's buffer (pH 6.8), and 0.15% aqueous solution of the above sample. Add 0.9ml, 3
It was incubated for 10 minutes in a constant temperature water bath at 7°C. Add 0.1 ml of tyrosinase aqueous solution (1 mg/ml) to this.
After stirring well and incubating at 37° C. for 12 minutes, the mixture was set in a spectrophotometer and the absorbance at 475 nm was measured. On the other hand, similar absorbance measurements were performed using distilled water instead of the sample as a blank, and the tyrosinase activity inhibition rate of each sample was calculated using the following formula. In addition, A in the formula
B means the absorbance when each sample is added, and B means the absorbance of the blank. Inhibition rate (%) = (1-A/B) x 100

The results of these tests are shown in Table 1. As is clear from Table 1, the water-soluble extract of Saxifrage obtained in Example-1 has a more remarkable ability to inhibit tyrosinase activity than the loofah water and the hot water extract of loofah, and furthermore, this composition It has good thermal stability, and after being left at 37°C for 2 weeks, it was found to have a stronger inhibitory effect on tyrosinase activity than vitamin C. Furthermore, these stability tests revealed that the water-soluble extract of Saxifrage did not exhibit any odor or discoloration. Furthermore, when the water-soluble extracts of plants of the Yukinoshita family obtained in Examples 2 to 4 were similarly tested, they were found to exhibit equally good tyrosinase activity inhibition ability.

[0028]

[Table 1]

Efficacy test example 2 Anti-inflammatory effect In order to examine the anti-inflammatory effect, samples were mixed at 0.01%, 0.1%, and 1.0%.
A histamine release inhibition test was conducted for each aqueous solution contained. As comparative examples, loofah water and a hot water extract of Aloe albopictus, which have been conventionally used in cosmetics, were similarly tested. The water-soluble extract of Saxifrage and loofah water were the same as those used in Experimental Example 1. In addition, as a method for preparing a hot water extract (comparative example) of Kidachialoe, 10g of dried product
was heated and extracted with 300 ml of water for 3 hours, and lyophilized under vacuum (containing more than 99% solids).

Histamine release inhibition test; report by Hirai et al. (
Journal of Pharmaceutical Sciences, 37, 374, 1983. ), the inhibitory effect on histamine release on mast cells collected intraperitoneally from male Spraque-Dawley rats (200 to 450 g) was measured. That is, the effect of suppressing histamine release by 4 ppm of compound 48/80 was determined as release inhibition rate (%).

The results are shown in Table 2. From these results, the hot water extract of Saxifrage obtained in Example 1 was found to have a remarkable effect of inhibiting histamine release and also has excellent anti-inflammatory effect, compared to loofah water and the hot water extract of Aloe albopictus. I discovered that. Furthermore, when the water-soluble extracts of plants of the Yukinoshita family obtained in Examples 2 to 4 were similarly tested, they were found to exhibit good anti-inflammatory effects.

[0032]

[Table 2]

Efficacy Test Example 3 Usage Test A usage test was conducted using 30 healthy subjects. The sample is Example-5
Cosmetics No. 6 and No. 6 were used, and the weight percent of the water-soluble extract of a plant belonging to the Yukinoshita family was varied. A UV-B lamp (Toshiba F
L-20SE) was used to irradiate ultraviolet rays with an intensity of 3 mw/cm2 for 1 minute. After each sample was applied to each site twice a day in the morning and evening for three days, the anti-inflammation effect was evaluated through a questionnaire survey. A questionnaire survey was also conducted to evaluate the pigmentation suppressing effect after one month of use. Note that one site that was irradiated with ultraviolet rays was used as a control in which nothing was applied. The evaluation criteria of the questionnaire were based on the following and compared with the control. (Judgment criteria) Valid ◎
Slightly effective ○Almost ineffective △Ineffective
×

[0034]

[Table 3-1]

[0035]

[Table 3-2]

The results shown in Table 3 show that the cosmetics used in the present invention exhibit a remarkable effect of suppressing inflammation and pigmentation after sunburn.

Efficacy Test Example 4 Safety Test In order to clarify the safety of the water-soluble extract of the Yukinoshita family plant of the present invention, a primary irritation test on humans was conducted by an occlusive patch test. That is, the fin chamber (EPI
(manufactured by TEST) was applied to 30 healthy people on the flexor side of their forearm for 48 hours, and after removal of the patch test bandage, the average value of the results 1 hour, 24 hours, and 48 hours later was calculated. The judgment was made using The sample used was the water-soluble extract obtained in Example-1, the coating concentration was 10% (W/W) aqueous solution, and distilled water was used as a control. As a result of the evaluation, no erythema was observed with the water-soluble extract of Saxifrage, while slight erythema was observed in 5 subjects with the control distilled water. These results confirmed that the water-soluble extract of Saxifrage has extremely low primary irritation and is highly safe for the skin. In addition, the water-soluble extracts of plants of the Yukinoshita family obtained in Examples 2 to 4 were similarly tested and found to be similarly highly safe for the skin.

Claims (1)

[Claims] 1. A cosmetic product containing a water-soluble extract of a plant belonging to the Yukinoshita family.