JPH0363211A - Cosmetic for fair skin and beauty - Google Patents
Cosmetic for fair skin and beautyInfo
- Publication number
- JPH0363211A JPH0363211A JP20096589A JP20096589A JPH0363211A JP H0363211 A JPH0363211 A JP H0363211A JP 20096589 A JP20096589 A JP 20096589A JP 20096589 A JP20096589 A JP 20096589A JP H0363211 A JPH0363211 A JP H0363211A
- Authority
- JP
- Japan
- Prior art keywords
- skin
- urocanic acid
- cosmetic
- ethyl ester
- beauty
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 23
- 230000003796 beauty Effects 0.000 title abstract 3
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 claims abstract description 18
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 14
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 claims abstract description 13
- OGNSCSPNOLGXSM-UHFFFAOYSA-N (+/-)-DABA Natural products NCCC(N)C(O)=O OGNSCSPNOLGXSM-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims abstract description 7
- 230000002087 whitening effect Effects 0.000 claims description 21
- 125000004494 ethyl ester group Chemical group 0.000 claims description 9
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 abstract description 18
- 230000000694 effects Effects 0.000 abstract description 16
- 239000006210 lotion Substances 0.000 abstract description 7
- 238000002156 mixing Methods 0.000 abstract description 5
- 230000015572 biosynthetic process Effects 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 3
- 239000003963 antioxidant agent Substances 0.000 abstract description 2
- 239000006071 cream Substances 0.000 abstract description 2
- 239000004094 surface-active agent Substances 0.000 abstract description 2
- 239000000463 material Substances 0.000 abstract 3
- 239000000975 dye Substances 0.000 abstract 2
- 230000002421 anti-septic effect Effects 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- -1 antiseptic Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 40
- 238000012360 testing method Methods 0.000 description 17
- 210000000434 stratum corneum Anatomy 0.000 description 8
- 230000007306 turnover Effects 0.000 description 6
- 239000000049 pigment Substances 0.000 description 5
- 206010040880 Skin irritation Diseases 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 210000000245 forearm Anatomy 0.000 description 4
- 238000011084 recovery Methods 0.000 description 4
- 230000036556 skin irritation Effects 0.000 description 4
- 231100000475 skin irritation Toxicity 0.000 description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
- 229940124277 aminobutyric acid Drugs 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000002884 skin cream Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 201000001880 Sexual dysfunction Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 206010042496 Sunburn Diseases 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003712 anti-aging effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000007850 fluorescent dye Substances 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 235000019271 petrolatum Nutrition 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000037204 skin physiology Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【発明の詳細な説明】
(技術分野)
本発明は、皮膚安全性に優れ、色黒の皮膚を予防する効
果と、色黒の皮膚を速かに淡色化する効果を有する美白
化粧料に関する。DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to a whitening cosmetic that has excellent skin safety, has the effect of preventing dark skin, and has the effect of quickly lightening dark skin.
(従来技術)
日焼けによる色黒の皮膚は、皮膚内に存在するチロシン
がチロシナーゼの作用により酸化されてメラニン色素と
なり、このメラニンが過剰に生成することに基因すると
されている。この色素沈着を予防或いは治療すべく、従
来よりL−アスコルビン酸及びその誘導体、コロイド状
硫黄、過酸化水素、ハイドロキノン等を配合してなる美
白化粧料が提案されている。しかし、これらの美白化粧
料は、保存安定性が不充分であるか、或いは美白効果が
充分に認められないものであったり、または、色黒の皮
膚を淡色化する効果を認められるが、皮膚安全性上に問
題が生じるものであって、優れた美白化粧料を得ること
は困難であった。(Prior Art) Dark skin due to sunburn is said to be caused by the fact that tyrosine present in the skin is oxidized to melanin pigment by the action of tyrosinase, and this melanin is produced in excess. In order to prevent or treat this pigmentation, whitening cosmetics containing L-ascorbic acid and its derivatives, colloidal sulfur, hydrogen peroxide, hydroquinone, etc. have been proposed. However, these whitening cosmetics either have insufficient storage stability or do not have sufficient whitening effects, or they have the effect of lightening dark skin, but they do not work well on the skin. This poses a safety problem, and it has been difficult to obtain an excellent whitening cosmetic.
(発明の開示)
そこで、本発明者らは、■表皮に過剰に存在するメラニ
ンを速かに排除すること、■新たに皮膚内にメラニンが
生成することを抑制すること、■しかも、皮膚安全性上
に問題がないこと等を満足する美白化粧料を目的として
、鋭意研究した結果、γ−ア果ノ酪酸と、ウロカニン酸
および/またはそのエチルエステルを配合してなる美白
化粧料が上記の目的を達成することを見出し、本発明を
完成した。(Disclosure of the Invention) Therefore, the present inventors have aimed to: 1) rapidly eliminate melanin present in excess in the epidermis, 2) suppress new melanin generation within the skin, and 2) ensure skin safety. As a result of intensive research with the aim of creating a whitening cosmetic that satisfies no sexual problems, we have found a whitening cosmetic that is a combination of γ-anobutyric acid and urocanic acid and/or its ethyl ester. The inventors have found that the object can be achieved and have completed the present invention.
(発明の目的)
即ち、本発明の目的は、皮膚刺激がなく、メラニン色素
形成抑制効果と色黒の皮膚を速やかに淡色化する効果を
有する優れた美白化粧料を提供するにある。(Objective of the Invention) That is, the object of the present invention is to provide an excellent whitening cosmetic that does not cause skin irritation, has the effect of inhibiting melanin pigment formation, and has the effect of quickly lightening dark skin.
(発明の構成)
本発明は、T−アミノ酪酸と、ウロカニン酸および/ま
たはそのエチルエステルとを配合してなる美白化粧料で
ある。(Structure of the Invention) The present invention is a whitening cosmetic comprising T-aminobutyric acid and urocanic acid and/or its ethyl ester.
(構成の具体的な説明)
本発明に係るγ−アミノ酪酸は公知の物質であって、特
開昭51−148041号公報には、皮膚&[l織賦活
作用による皮膚老化防止効果を有することが記載されて
いる。また、ウロカニン酸及びそのエチルエステルも公
知の物質であり、特公昭58−35513号公報にはウ
ロカニン酸エチルエステルの製造法と共に、これらの物
質が紫外線吸収剤として有効であることが記載されてい
る。(Specific explanation of the structure) The γ-aminobutyric acid according to the present invention is a known substance, and is disclosed in Japanese Patent Application Laid-Open No. 148041/1983 that it has an anti-aging effect on the skin due to the skin and tissue activation effect. is listed. In addition, urocanic acid and its ethyl ester are also known substances, and Japanese Patent Publication No. 58-35513 describes a method for producing urocanic acid ethyl ester and that these substances are effective as ultraviolet absorbers. .
本発明者らは、化粧料基剤中に共存するT−アミノ酪酸
とウロカニン酸またはそのエチルエステルが、従来より
知られているこれらの個々の作用効果とくらべて、顕著
に優れた相乗効果を発揮することを確認し本発明を完成
するに至った。The present inventors have discovered that T-aminobutyric acid and urocanic acid or their ethyl ester coexisting in a cosmetic base exhibit a synergistic effect that is significantly superior to that of their individual effects that have been known in the past. The present invention was completed after confirming that the present invention was effective.
即ち、T−アミノ酪酸の皮膚組織を賦活して、角質層の
ターンオーバ速度を促進し、かつメラニンを角質層と共
に速かに排除して色黒の皮膚を淡色化する効果と、ウロ
カニン酸或いはそのエチルエステルの潜在する皮膚のメ
ラニン形成能を抑制し、新たに色黒の皮膚となることを
予防する効果とが相乗して、皮膚生理学上に好ましい条
件下で色黒の皮膚を淡色化する効果を発現することが新
たに認められた。In other words, T-aminobutyric acid activates the skin tissue, accelerates the turnover rate of the stratum corneum, and rapidly eliminates melanin together with the stratum corneum to lighten dark skin, and urocanic acid or The effect of suppressing the latent skin melanin formation ability of the ethyl ester and preventing new dark-skinned skin is combined to lighten dark-skinned skin under conditions favorable to skin physiology. It has been newly recognized that this drug is effective.
よって、本発明の美白化粧料は、太陽光に曝された後の
色黒になる以前の皮膚または色黒となった皮膚を対象と
して、特に皮膚生理学上不安定となった皮膚に塗布し、
皮膚刺激を生じることなく、皮膚色が黒色化すること或
いは色黒の皮膚を淡色化することに於いて、顕著な効果
を呈するものである。Therefore, the whitening cosmetic of the present invention is applied to skin that has not darkened or has darkened after exposure to sunlight, especially skin that has become physiologically unstable.
It exhibits a remarkable effect in darkening the skin color or lightening dark skin without causing skin irritation.
本発明の美白化粧料は、前記のT−7ミノ酪酸と、ウロ
カニン酸および/またはそのエチルエステルを周知のク
リーム類、乳液類、ローシロン類である化粧料基剤に、
通常の方法にて、配合して調製される。The whitening cosmetic of the present invention includes the above-mentioned T-7 minobutyric acid and urocanic acid and/or its ethyl ester in a cosmetic base such as well-known creams, milky lotions, and rosilons.
It is prepared by blending in a conventional manner.
γ−アミノ酪酸の配合量は、当該化粧料の総量を基準と
して、0.05〜3.0重量%(以下、wt%と略記す
る)、また、ウロカニン酸及びそのエチルエステルの配
合量は、各々の単独または両者の合計量で0.05〜3
.Q w t%であればよい、これらの配合量の上限を
超えてもその超えた配合量に見合った効果は期待できず
、また下限未満の配合量では、本発明の目的を達成する
に至らないものである。The amount of γ-aminobutyric acid is 0.05 to 3.0% by weight (hereinafter abbreviated as wt%) based on the total amount of the cosmetic, and the amount of urocanic acid and its ethyl ester is: 0.05 to 3 for each alone or the total amount of both
.. Q w t% is sufficient. Even if the upper limit of these blending amounts is exceeded, no effect commensurate with the exceeding blending amount can be expected, and if the blending amount is less than the lower limit, it will not be possible to achieve the purpose of the present invention. It's something that doesn't exist.
尚、本発明の美白化粧料には、色素、香料、防腐剤、抗
酸化剤、界面活性剤、皮膚栄養剤、顔料等を本発明の目
的を達成する範囲内で適宜配合することができる。The whitening cosmetic of the present invention may contain pigments, fragrances, preservatives, antioxidants, surfactants, skin nutrients, pigments, and the like as appropriate within the scope of achieving the purpose of the present invention.
(実施例) 以下、実施例にて本発明を説明する。(Example) The present invention will be explained below with reference to Examples.
尚、実施例に記載の■皮膚刺激試験、■角質層のターン
オーバー速度測定試験■皮膚色明度回復試験、■美白実
用試験を下記に示す。In addition, (1) skin irritation test, (2) stratum corneum turnover rate measurement test, (2) skin color brightness recovery test, and (2) whitening practical test described in Examples are shown below.
■ 皮膚刺激試験
夏期の太陽光に6時間(1日3時間で2日間)曝された
被検者25名の前腕層側部皮膚に、試料0、05 gを
直径1. Q c mの円型のリント布のついたバッチ
テスト用絆創膏を用いて24時間閉塞貼付した後、下記
の第2表の判定基準に従い、各試料について被検者25
名の皮膚の状態を評価判定した。判定結果は、絆創膏除
去1時間後及び24時間後のうち反応の強い方を採用し
、評価が(±)以上の人の数で示した。■ Skin irritation test 0.05 g of sample was applied to the side skin of the forearm layer of 25 subjects exposed to summer sunlight for 6 hours (3 hours a day for 2 days) with a diameter of 1.5 g. After 24 hours of occlusive application using a batch test bandage with Q cm circular lint cloth, each sample was applied to 25 subjects according to the criteria in Table 2 below.
The condition of the skin was evaluated. The evaluation results were determined based on the stronger reaction between 1 hour and 24 hours after removal of the bandage, and expressed as the number of people who rated (±) or higher.
第1表 判定基準
■ 角質層のターンオーバー速度測定試験蛍光色素のダ
ンジルクロライドを白色ワセリン中に5wt%配合した
軟膏を作り、被検者20名の前腕屈側部の皮膚に24時
間閉塞貼付し、角質層にダンジルクロライドを浸透結合
させる。その後回し部位に1日2回(朝、夕)被検試料
を塗布し、毎日ダンジルクロライドの蛍光をしらべ、そ
の蛍光が消滅するまでの日数を皮膚角質層のターンオー
バ速度とした。測定結果は各M検者の日数の平均値で示
した。Table 1 Judgment Criteria■ Test for measuring the turnover rate of the stratum corneum An ointment containing 5 wt% of the fluorescent dye danzyl chloride in white petrolatum was prepared and applied as an occluded patch on the skin of the flexor side of the forearm of 20 subjects for 24 hours. and allows danzyl chloride to penetrate and bind to the stratum corneum. Thereafter, a test sample was applied to the area twice a day (morning and evening), the fluorescence of danzyl chloride was examined every day, and the number of days until the fluorescence disappeared was defined as the turnover rate of the skin stratum corneum. The measurement results were shown as the average value of the number of days for each M examiner.
なお、通常の皮膚角質層のターンオーバー速度は、14
〜16日である。Note that the normal turnover rate of the stratum corneum of the skin is 14
~16th.
■ 皮膚色明度回復試験
被試験者20名の背部皮膚にUV−B領域の紫外線を最
小紅班量の2倍量照射し、1周間の後、その照射部に試
料塗布部位と非塗布部位とを設定して各々の皮膚の基準
明度(Vo値、Vo’値)を測定した。引き続いて塗布
部位には試料を1日1回ずつ3ケ月間連続塗布し、3,
8.13週間後の塗布部位及び非塗布部位の皮膚の明度
(Vn・・・値、Vn’・・・値)を測定して、第2表
の判定基準により皮膚色の回復評価を実施した。■ Skin color brightness recovery test The back skin of 20 test subjects was irradiated with ultraviolet rays in the UV-B region at twice the minimum amount of erythema, and after one round, the irradiated area was divided into areas where the sample was applied and areas where the sample was not applied. The reference brightness (Vo value, Vo' value) of each skin was measured. Subsequently, the sample was continuously applied to the application site once a day for 3 months.
8. After 13 weeks, the skin brightness (Vn value, Vn' value) of the applied and non-applied areas was measured, and skin color recovery was evaluated according to the criteria in Table 2. .
尚、皮膚の明度(マンセル表色系V値)は高速分光色彩
計で測定して得られたx、y、z値より算出した。また
、評価は被試験者20名の13週間後の評価点の平均値
で示した。In addition, the brightness of the skin (Munsell color system V value) was calculated from the x, y, and z values obtained by measurement with a high-speed spectrocolorimeter. Moreover, the evaluation was shown as the average value of the evaluation scores of 20 test subjects after 13 weeks.
■ 美白実用試験
夏期の太陽光に3時間(1日1.5時間で2日間)曝さ
れた被検者20名の前腕層側部皮膚を対象として、左前
腕屈側部には太陽光に曝された日の翌日より、また右前
腕屈側部には太陽光に曝された日の7日後より各々試料
を朝夕1回ずつ13週間連続塗布した。■ Whitening practical test The skin on the side of the forearm layer of 20 subjects who were exposed to sunlight for 3 hours (1.5 hours a day for 2 days) in the summer was tested. Starting from the day after the day of exposure and from 7 days after the day of exposure to sunlight, each sample was continuously applied once in the morning and evening for 13 weeks on the flexor side of the right forearm.
評価は、試料を塗布した皮膚の部分が他の皮膚の部分よ
り色白(淡色化)となったと回答した被検者の数で示し
た。The evaluation was expressed by the number of subjects who answered that the skin area to which the sample was applied had a fairer complexion (lightening) than other skin areas.
実施例1〜4、比較例1〜4
に4型ローシヨン〕
下記の組成に於いて、第3表左欄に示す通りにγ−アミ
ノ酪酸、ウロカニン酸及びそのエチルエステルの配合量
を変えて、各々の二層型ローションを調製して諸試験を
実施した。その結果を第3(1)
Mi威
(21m製法
(A) 、(B)成分を各々均一に溶解した後、(A)
成分と(B)成分を混合撹拌分散し、次いで容器に充填
する。Examples 1 to 4, Comparative Examples 1 to 4 Type 4 lotion] In the following composition, the amounts of γ-aminobutyric acid, urocanic acid and its ethyl ester were changed as shown in the left column of Table 3, Each two-layer lotion was prepared and tested. The results are summarized in Section 3 (1).
The components and component (B) are mixed, stirred and dispersed, and then filled into a container.
使用時には内容物を均一に振盪分散して使用する。When using, shake and disperse the contents uniformly.
(3) 特性
第3表に示すごとく、比較例1〜4の二層型ローション
基剤及びこの基剤にγ−アミノ酪酸、ウロカニン酸、ウ
ロカニン酸エチルエステルを各々単独で配合したローシ
ョンでは角質層ターンオーバ速度がやや速くなり日数が
減少する効果が認められるが、皮膚色明度回復試験及び
美白実用試験に於いて充分なる効果は得られない、実施
例1〜4の本発明の美白化粧料は諸試験の評価がすべて
良好である。(3) Properties As shown in Table 3, the two-layer lotion bases of Comparative Examples 1 to 4 and the lotions in which γ-aminobutyric acid, urocanic acid, and urocanic acid ethyl ester were each individually blended with the bases showed that the stratum corneum The skin whitening cosmetics of the present invention of Examples 1 to 4 were found to have the effect of slightly increasing the turnover rate and reducing the number of days, but no sufficient effect was obtained in the skin color brightness recovery test and the whitening practical test. All tests have been evaluated favorably.
実施例5〜9、比較例5〜7
〔スキンクリーム〕
実施例1と同様に、下記の組成に於いて各々のスキンク
リームを調製して諸試験を実施し、その組成
伐) 調製法
(^) 、(B)成分を各々均一に加熱溶解して温度を
80℃にした後、(B)成分中に(^)成分を注入撹拌
混合する0次いで、撹拌しながら温度を30℃迄冷却す
る。Examples 5 to 9, Comparative Examples 5 to 7 [Skin cream] In the same manner as in Example 1, each skin cream was prepared with the following composition and various tests were conducted, and the composition was determined) Preparation method (^ ), (B) components are each uniformly heated and dissolved to bring the temperature to 80°C, then the (^) component is poured into the (B) component and mixed with stirring.Next, the temperature is cooled to 30°C while stirring. .
(3) 特性
第4表に示すごとく、比較例5〜7に対して本発明の美
白化粧料である実施例5〜9は諸試験に於いてすべて良
好な結果を示し、美白効果も優れ(発明の効果)
以上記載の如く、本発明の美白化粧料は、皮膚安全性が
高く、メラニン色素形成抑制効果と色黒の皮膚を速やか
に淡色化する効果を有することが明らかであり、特に太
陽光等に曝された後、速やかに使用することによって、
更に一段と美白効果が向上することが認められた。(3) Properties As shown in Table 4, Examples 5 to 9, which are the whitening cosmetics of the present invention, showed better results in all tests compared to Comparative Examples 5 to 7, and the whitening effect was also excellent ( Effects of the Invention) As described above, it is clear that the whitening cosmetic of the present invention has high skin safety, has the effect of inhibiting melanin pigment formation, and has the effect of quickly lightening dark skin, and is particularly effective against sunlight. By using it immediately after exposure to light, etc.
Furthermore, it was observed that the whitening effect was further improved.
Claims (1)
チルエステルとを配合してなる美白化粧料。A whitening cosmetic containing γ-aminobutyric acid and urocanic acid and/or its ethyl ester.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20096589A JPH0363211A (en) | 1989-08-02 | 1989-08-02 | Cosmetic for fair skin and beauty |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20096589A JPH0363211A (en) | 1989-08-02 | 1989-08-02 | Cosmetic for fair skin and beauty |
Publications (1)
Publication Number | Publication Date |
---|---|
JPH0363211A true JPH0363211A (en) | 1991-03-19 |
Family
ID=16433264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP20096589A Pending JPH0363211A (en) | 1989-08-02 | 1989-08-02 | Cosmetic for fair skin and beauty |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0363211A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723645A (en) * | 1996-09-05 | 1998-03-03 | Pacific Corporation | Method for preparing 3-aminopropane phosphoric acid |
JP2009107931A (en) * | 2007-10-26 | 2009-05-21 | Kracie Home Products Kk | Skin function improver |
JP2010511021A (en) * | 2006-11-30 | 2010-04-08 | コーエン,マルセル | Use of gamma aminobutyric acid as a depigmenting agent. |
JP2011148737A (en) * | 2010-01-22 | 2011-08-04 | Kyoei Kagaku Kogyo Kk | Skin whitening cosmetic |
JP2012144566A (en) * | 2012-04-20 | 2012-08-02 | Kracie Home Products Ltd | Method for selecting active constituent in epidermal function ameliorating agent |
WO2018097276A1 (en) * | 2016-11-28 | 2018-05-31 | ポーラ化成工業株式会社 | Skin lightening agent |
JP2021088522A (en) * | 2019-12-03 | 2021-06-10 | 株式会社コーセー | V-atpase activity promoter |
-
1989
- 1989-08-02 JP JP20096589A patent/JPH0363211A/en active Pending
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5723645A (en) * | 1996-09-05 | 1998-03-03 | Pacific Corporation | Method for preparing 3-aminopropane phosphoric acid |
JP2010511021A (en) * | 2006-11-30 | 2010-04-08 | コーエン,マルセル | Use of gamma aminobutyric acid as a depigmenting agent. |
JP2009107931A (en) * | 2007-10-26 | 2009-05-21 | Kracie Home Products Kk | Skin function improver |
JP2011148737A (en) * | 2010-01-22 | 2011-08-04 | Kyoei Kagaku Kogyo Kk | Skin whitening cosmetic |
JP2012144566A (en) * | 2012-04-20 | 2012-08-02 | Kracie Home Products Ltd | Method for selecting active constituent in epidermal function ameliorating agent |
WO2018097276A1 (en) * | 2016-11-28 | 2018-05-31 | ポーラ化成工業株式会社 | Skin lightening agent |
JP2021088522A (en) * | 2019-12-03 | 2021-06-10 | 株式会社コーセー | V-atpase activity promoter |
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