JPH0511301B2 - - Google Patents
Info
- Publication number
- JPH0511301B2 JPH0511301B2 JP12222484A JP12222484A JPH0511301B2 JP H0511301 B2 JPH0511301 B2 JP H0511301B2 JP 12222484 A JP12222484 A JP 12222484A JP 12222484 A JP12222484 A JP 12222484A JP H0511301 B2 JPH0511301 B2 JP H0511301B2
- Authority
- JP
- Japan
- Prior art keywords
- silver halide
- emulsion
- silver
- development
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 229910052709 silver Inorganic materials 0.000 claims description 103
- 239000004332 silver Substances 0.000 claims description 103
- -1 silver halide Chemical class 0.000 claims description 103
- 239000000839 emulsion Substances 0.000 claims description 73
- 238000011161 development Methods 0.000 claims description 41
- 229910021645 metal ion Inorganic materials 0.000 claims description 11
- 239000010410 layer Substances 0.000 description 39
- 230000018109 developmental process Effects 0.000 description 38
- 239000000463 material Substances 0.000 description 29
- 108010010803 Gelatin Proteins 0.000 description 24
- 229920000159 gelatin Polymers 0.000 description 24
- 239000008273 gelatin Substances 0.000 description 24
- 235000019322 gelatine Nutrition 0.000 description 24
- 235000011852 gelatine desserts Nutrition 0.000 description 24
- 238000000034 method Methods 0.000 description 23
- 239000003795 chemical substances by application Substances 0.000 description 22
- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 18
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical group [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 17
- 239000007864 aqueous solution Substances 0.000 description 15
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 14
- 239000000975 dye Substances 0.000 description 13
- 239000000243 solution Substances 0.000 description 12
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 10
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- ADZWSOLPGZMUMY-UHFFFAOYSA-M silver bromide Chemical compound [Ag]Br ADZWSOLPGZMUMY-UHFFFAOYSA-M 0.000 description 9
- QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 150000001875 compounds Chemical class 0.000 description 7
- 229910001961 silver nitrate Inorganic materials 0.000 description 7
- 238000001179 sorption measurement Methods 0.000 description 7
- 238000012546 transfer Methods 0.000 description 7
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 229920001577 copolymer Polymers 0.000 description 6
- 239000004848 polyfunctional curative Substances 0.000 description 6
- 229910052700 potassium Inorganic materials 0.000 description 6
- 239000011591 potassium Substances 0.000 description 6
- 238000012545 processing Methods 0.000 description 6
- 230000035945 sensitivity Effects 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- 229910021607 Silver chloride Inorganic materials 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 239000000470 constituent Substances 0.000 description 5
- 230000007423 decrease Effects 0.000 description 5
- 150000004820 halides Chemical class 0.000 description 5
- 239000001103 potassium chloride Substances 0.000 description 5
- 235000011164 potassium chloride Nutrition 0.000 description 5
- 238000001556 precipitation Methods 0.000 description 5
- 230000005070 ripening Effects 0.000 description 5
- 230000001235 sensitizing effect Effects 0.000 description 5
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 5
- 235000010265 sodium sulphite Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- ZZXILYOBAFPJNS-UHFFFAOYSA-N 2-octylbenzene-1,4-diol Chemical compound CCCCCCCCC1=CC(O)=CC=C1O ZZXILYOBAFPJNS-UHFFFAOYSA-N 0.000 description 4
- LRUDIIUSNGCQKF-UHFFFAOYSA-N 5-methyl-1H-benzotriazole Chemical compound C1=C(C)C=CC2=NNN=C21 LRUDIIUSNGCQKF-UHFFFAOYSA-N 0.000 description 4
- JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 4
- 239000000654 additive Substances 0.000 description 4
- 239000011230 binding agent Substances 0.000 description 4
- 238000009792 diffusion process Methods 0.000 description 4
- MQRJBSHKWOFOGF-UHFFFAOYSA-L disodium;carbonate;hydrate Chemical compound O.[Na+].[Na+].[O-]C([O-])=O MQRJBSHKWOFOGF-UHFFFAOYSA-L 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Substances [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 4
- 239000011241 protective layer Substances 0.000 description 4
- 125000001424 substituent group Chemical group 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000005406 washing Methods 0.000 description 4
- VOZKAJLKRJDJLL-UHFFFAOYSA-N 2,4-diaminotoluene Chemical compound CC1=CC=C(N)C=C1N VOZKAJLKRJDJLL-UHFFFAOYSA-N 0.000 description 3
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 125000003118 aryl group Chemical group 0.000 description 3
- 239000000084 colloidal system Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- DDPJROKUKMXGPW-UHFFFAOYSA-N n-(4-methylanilino)formamide Chemical compound CC1=CC=C(NNC=O)C=C1 DDPJROKUKMXGPW-UHFFFAOYSA-N 0.000 description 3
- 230000006911 nucleation Effects 0.000 description 3
- 238000010899 nucleation Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 229920000139 polyethylene terephthalate Polymers 0.000 description 3
- 239000005020 polyethylene terephthalate Substances 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- ZUNKMNLKJXRCDM-UHFFFAOYSA-N silver bromoiodide Chemical compound [Ag].IBr ZUNKMNLKJXRCDM-UHFFFAOYSA-N 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- QIVUCLWGARAQIO-OLIXTKCUSA-N (3s)-n-[(3s,5s,6r)-6-methyl-2-oxo-1-(2,2,2-trifluoroethyl)-5-(2,3,6-trifluorophenyl)piperidin-3-yl]-2-oxospiro[1h-pyrrolo[2,3-b]pyridine-3,6'-5,7-dihydrocyclopenta[b]pyridine]-3'-carboxamide Chemical compound C1([C@H]2[C@H](N(C(=O)[C@@H](NC(=O)C=3C=C4C[C@]5(CC4=NC=3)C3=CC=CN=C3NC5=O)C2)CC(F)(F)F)C)=C(F)C=CC(F)=C1F QIVUCLWGARAQIO-OLIXTKCUSA-N 0.000 description 2
- GGZHVNZHFYCSEV-UHFFFAOYSA-N 1-Phenyl-5-mercaptotetrazole Chemical compound SC1=NN=NN1C1=CC=CC=C1 GGZHVNZHFYCSEV-UHFFFAOYSA-N 0.000 description 2
- CDAWCLOXVUBKRW-UHFFFAOYSA-N 2-aminophenol Chemical class NC1=CC=CC=C1O CDAWCLOXVUBKRW-UHFFFAOYSA-N 0.000 description 2
- JKFYKCYQEWQPTM-UHFFFAOYSA-N 2-azaniumyl-2-(4-fluorophenyl)acetate Chemical compound OC(=O)C(N)C1=CC=C(F)C=C1 JKFYKCYQEWQPTM-UHFFFAOYSA-N 0.000 description 2
- DSVIHYOAKPVFEH-UHFFFAOYSA-N 4-(hydroxymethyl)-4-methyl-1-phenylpyrazolidin-3-one Chemical compound N1C(=O)C(C)(CO)CN1C1=CC=CC=C1 DSVIHYOAKPVFEH-UHFFFAOYSA-N 0.000 description 2
- ZVNPWFOVUDMGRP-UHFFFAOYSA-N 4-methylaminophenol sulfate Chemical compound OS(O)(=O)=O.CNC1=CC=C(O)C=C1.CNC1=CC=C(O)C=C1 ZVNPWFOVUDMGRP-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 2
- 229920002284 Cellulose triacetate Polymers 0.000 description 2
- FZERHIULMFGESH-UHFFFAOYSA-N N-phenylacetamide Chemical compound CC(=O)NC1=CC=CC=C1 FZERHIULMFGESH-UHFFFAOYSA-N 0.000 description 2
- 229910021612 Silver iodide Inorganic materials 0.000 description 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- NNLVGZFZQQXQNW-ADJNRHBOSA-N [(2r,3r,4s,5r,6s)-4,5-diacetyloxy-3-[(2s,3r,4s,5r,6r)-3,4,5-triacetyloxy-6-(acetyloxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6s)-4,5,6-triacetyloxy-2-(acetyloxymethyl)oxan-3-yl]oxyoxan-2-yl]methyl acetate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](OC(C)=O)[C@H]1OC(C)=O)O[C@H]1[C@@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)OC(C)=O)COC(=O)C)[C@@H]1[C@@H](COC(C)=O)O[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O NNLVGZFZQQXQNW-ADJNRHBOSA-N 0.000 description 2
- 239000006096 absorbing agent Substances 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- 150000007513 acids Chemical class 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- IOJUPLGTWVMSFF-UHFFFAOYSA-N benzothiazole Chemical class C1=CC=C2SC=NC2=C1 IOJUPLGTWVMSFF-UHFFFAOYSA-N 0.000 description 2
- WZTQWXKHLAJTRC-UHFFFAOYSA-N benzyl 2-amino-6,7-dihydro-4h-[1,3]thiazolo[5,4-c]pyridine-5-carboxylate Chemical compound C1C=2SC(N)=NC=2CCN1C(=O)OCC1=CC=CC=C1 WZTQWXKHLAJTRC-UHFFFAOYSA-N 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- DNSISZSEWVHGLH-UHFFFAOYSA-N butanamide Chemical compound CCCC(N)=O DNSISZSEWVHGLH-UHFFFAOYSA-N 0.000 description 2
- 125000004432 carbon atom Chemical group C* 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 239000011248 coating agent Substances 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- DOIRQSBPFJWKBE-UHFFFAOYSA-N dibutyl phthalate Chemical compound CCCCOC(=O)C1=CC=CC=C1C(=O)OCCCC DOIRQSBPFJWKBE-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
- 125000000623 heterocyclic group Chemical group 0.000 description 2
- 150000002429 hydrazines Chemical class 0.000 description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 2
- 229910052741 iridium Inorganic materials 0.000 description 2
- RLJMLMKIBZAXJO-UHFFFAOYSA-N lead nitrate Chemical compound [O-][N+](=O)O[Pb]O[N+]([O-])=O RLJMLMKIBZAXJO-UHFFFAOYSA-N 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- SKDQTLDBZMLKQA-UHFFFAOYSA-N n-[4-(phenylcarbamothioylamino)anilino]formamide Chemical compound C1=CC(NNC=O)=CC=C1NC(=S)NC1=CC=CC=C1 SKDQTLDBZMLKQA-UHFFFAOYSA-N 0.000 description 2
- CMCWWLVWPDLCRM-UHFFFAOYSA-N phenidone Chemical compound N1C(=O)CCN1C1=CC=CC=C1 CMCWWLVWPDLCRM-UHFFFAOYSA-N 0.000 description 2
- 239000004014 plasticizer Substances 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 230000001376 precipitating effect Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- JEXVQSWXXUJEMA-UHFFFAOYSA-N pyrazol-3-one Chemical compound O=C1C=CN=N1 JEXVQSWXXUJEMA-UHFFFAOYSA-N 0.000 description 2
- 229940045105 silver iodide Drugs 0.000 description 2
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 2
- 235000019345 sodium thiosulphate Nutrition 0.000 description 2
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
- HMHWNJGOHUYVMD-UHFFFAOYSA-N (4-methylanilino)azanium;chloride Chemical compound Cl.CC1=CC=C(NN)C=C1 HMHWNJGOHUYVMD-UHFFFAOYSA-N 0.000 description 1
- LUMLZKVIXLWTCI-NSCUHMNNSA-N (e)-2,3-dichloro-4-oxobut-2-enoic acid Chemical compound OC(=O)C(\Cl)=C(/Cl)C=O LUMLZKVIXLWTCI-NSCUHMNNSA-N 0.000 description 1
- VNPBXWLZWAMGEO-UHFFFAOYSA-N 1,1-diethyl-2-(2-methylphenyl)hydrazine Chemical compound CCN(CC)NC1=CC=CC=C1C VNPBXWLZWAMGEO-UHFFFAOYSA-N 0.000 description 1
- HQWALKUMPUZAIR-UHFFFAOYSA-N 1,3-benzoselenazol-3-ium;bromide Chemical compound [Br-].C1=CC=C2[se]C=[NH+]C2=C1 HQWALKUMPUZAIR-UHFFFAOYSA-N 0.000 description 1
- 150000000183 1,3-benzoxazoles Chemical class 0.000 description 1
- SLYRGJDSFOCAAI-UHFFFAOYSA-N 1,3-thiazolidin-2-one Chemical compound O=C1NCCS1 SLYRGJDSFOCAAI-UHFFFAOYSA-N 0.000 description 1
- CMCBDXRRFKYBDG-UHFFFAOYSA-N 1-dodecoxydodecane Chemical compound CCCCCCCCCCCCOCCCCCCCCCCCC CMCBDXRRFKYBDG-UHFFFAOYSA-N 0.000 description 1
- CLDZVCMRASJQFO-UHFFFAOYSA-N 2,5-bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol Chemical compound CC(C)(C)CC(C)(C)C1=CC(O)=C(C(C)(C)CC(C)(C)C)C=C1O CLDZVCMRASJQFO-UHFFFAOYSA-N 0.000 description 1
- QTLHLXYADXCVCF-UHFFFAOYSA-N 2-(4-amino-n-ethyl-3-methylanilino)ethanol Chemical compound OCCN(CC)C1=CC=C(N)C(C)=C1 QTLHLXYADXCVCF-UHFFFAOYSA-N 0.000 description 1
- JHKKTXXMAQLGJB-UHFFFAOYSA-N 2-(methylamino)phenol Chemical compound CNC1=CC=CC=C1O JHKKTXXMAQLGJB-UHFFFAOYSA-N 0.000 description 1
- WZFUQSJFWNHZHM-UHFFFAOYSA-N 2-[4-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]piperazin-1-yl]-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethanone Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)N1CCN(CC1)CC(=O)N1CC2=C(CC1)NN=N2 WZFUQSJFWNHZHM-UHFFFAOYSA-N 0.000 description 1
- KFAGFICBFWGIAW-UHFFFAOYSA-M 3-(2-methyl-1,3-benzothiazol-3-ium-3-yl)propanal;bromide Chemical compound [Br-].C1=CC=C2[N+](CCC=O)=C(C)SC2=C1 KFAGFICBFWGIAW-UHFFFAOYSA-M 0.000 description 1
- PYSRRFNXTXNWCD-UHFFFAOYSA-N 3-(2-phenylethenyl)furan-2,5-dione Chemical compound O=C1OC(=O)C(C=CC=2C=CC=CC=2)=C1 PYSRRFNXTXNWCD-UHFFFAOYSA-N 0.000 description 1
- UVBJXPUIEFOBSW-UHFFFAOYSA-M 3-(2-propyl-1,3-benzothiazol-3-ium-3-yl)propanal;bromide Chemical compound [Br-].C1=CC=C2[N+](CCC=O)=C(CCC)SC2=C1 UVBJXPUIEFOBSW-UHFFFAOYSA-M 0.000 description 1
- VBNUEXVIMODPSF-UHFFFAOYSA-M 3-methyl-4-phenyl-1,2-dihydropyrido[2,1-b][1,3]benzothiazol-10-ium;bromide Chemical compound [Br-].C1=2SC3=CC=CC=C3[N+]=2CCC(C)=C1C1=CC=CC=C1 VBNUEXVIMODPSF-UHFFFAOYSA-M 0.000 description 1
- SJSJAWHHGDPBOC-UHFFFAOYSA-N 4,4-dimethyl-1-phenylpyrazolidin-3-one Chemical compound N1C(=O)C(C)(C)CN1C1=CC=CC=C1 SJSJAWHHGDPBOC-UHFFFAOYSA-N 0.000 description 1
- DCKXKFYYFIZDGN-UHFFFAOYSA-M 4-(2-benzyl-1,3-benzoselenazol-3-ium-3-yl)butan-2-one;bromide Chemical compound [Br-].[se]1C2=CC=CC=C2[N+](CCC(=O)C)=C1CC1=CC=CC=C1 DCKXKFYYFIZDGN-UHFFFAOYSA-M 0.000 description 1
- PNUBARHEWRYSLN-UHFFFAOYSA-N 4-(3-methyl-5-oxo-2-sulfanylideneimidazolidin-1-yl)benzenesulfonamide Chemical compound CN1C(=S)N(C(=O)C1)C1=CC=C(C=C1)S(N)(=O)=O PNUBARHEWRYSLN-UHFFFAOYSA-N 0.000 description 1
- SRRFCUFJSXBXEQ-UHFFFAOYSA-N 4-[2-[1-(2-methyl-1,3-benzothiazol-3-ium-3-yl)pentan-3-ylidene]hydrazinyl]benzenesulfonic acid;iodide Chemical compound [I-].CC=1SC2=CC=CC=C2[N+]=1CCC(CC)=NNC1=CC=C(S(O)(=O)=O)C=C1 SRRFCUFJSXBXEQ-UHFFFAOYSA-N 0.000 description 1
- OTEXGBUFBLPYIA-UHFFFAOYSA-N 4-[2-[3-(2-methyl-1,3-benzothiazol-3-ium-3-yl)propylidene]hydrazinyl]benzenesulfonic acid;bromide Chemical compound [Br-].CC=1SC2=CC=CC=C2[N+]=1CCC=NNC1=CC=C(S(O)(=O)=O)C=C1 OTEXGBUFBLPYIA-UHFFFAOYSA-N 0.000 description 1
- HWAOQCPYJVJUCR-UHFFFAOYSA-M 4-methyl-n-[3-(2-methyl-1,3-benzothiazol-3-ium-3-yl)propylideneamino]aniline;bromide Chemical compound [Br-].CC=1SC2=CC=CC=C2[N+]=1CCC=NNC1=CC=C(C)C=C1 HWAOQCPYJVJUCR-UHFFFAOYSA-M 0.000 description 1
- QNGVNLMMEQUVQK-UHFFFAOYSA-N 4-n,4-n-diethylbenzene-1,4-diamine Chemical compound CCN(CC)C1=CC=C(N)C=C1 QNGVNLMMEQUVQK-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical compound C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920001747 Cellulose diacetate Polymers 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- OWYWGLHRNBIFJP-UHFFFAOYSA-N Ipazine Chemical compound CCN(CC)C1=NC(Cl)=NC(NC(C)C)=N1 OWYWGLHRNBIFJP-UHFFFAOYSA-N 0.000 description 1
- 239000002211 L-ascorbic acid Substances 0.000 description 1
- 235000000069 L-ascorbic acid Nutrition 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
- CWNSVVHTTQBGQB-UHFFFAOYSA-N N,N-Diethyldodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CC)CC CWNSVVHTTQBGQB-UHFFFAOYSA-N 0.000 description 1
- ISLYUUGUJKSGDZ-UHFFFAOYSA-N OC1=CC=NC2=NC=NN12 Chemical compound OC1=CC=NC2=NC=NN12 ISLYUUGUJKSGDZ-UHFFFAOYSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002873 Polyethylenimine Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 241000978776 Senegalia senegal Species 0.000 description 1
- 206010070834 Sensitisation Diseases 0.000 description 1
- 229920000147 Styrene maleic anhydride Polymers 0.000 description 1
- 241001061127 Thione Species 0.000 description 1
- SJOOOZPMQAWAOP-UHFFFAOYSA-N [Ag].BrCl Chemical compound [Ag].BrCl SJOOOZPMQAWAOP-UHFFFAOYSA-N 0.000 description 1
- XCFIVNQHHFZRNR-UHFFFAOYSA-N [Ag].Cl[IH]Br Chemical compound [Ag].Cl[IH]Br XCFIVNQHHFZRNR-UHFFFAOYSA-N 0.000 description 1
- DQDAKTWBGHIMSE-UHFFFAOYSA-M [Br-].CC1=CC=2SC3=C([N+]2CC1)C=CC=C3 Chemical compound [Br-].CC1=CC=2SC3=C([N+]2CC1)C=CC=C3 DQDAKTWBGHIMSE-UHFFFAOYSA-M 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 229960001413 acetanilide Drugs 0.000 description 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 description 1
- 125000003647 acryloyl group Chemical group O=C([*])C([H])=C([H])[H] 0.000 description 1
- 108091005647 acylated proteins Proteins 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- BIVUUOPIAYRCAP-UHFFFAOYSA-N aminoazanium;chloride Chemical compound Cl.NN BIVUUOPIAYRCAP-UHFFFAOYSA-N 0.000 description 1
- 229910001439 antimony ion Inorganic materials 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 239000002216 antistatic agent Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- QVQLCTNNEUAWMS-UHFFFAOYSA-N barium oxide Chemical compound [Ba]=O QVQLCTNNEUAWMS-UHFFFAOYSA-N 0.000 description 1
- 229910001864 baryta Inorganic materials 0.000 description 1
- 150000001556 benzimidazoles Chemical class 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- QRUDEWIWKLJBPS-UHFFFAOYSA-N benzotriazole Chemical compound C1=CC=C2N[N][N]C2=C1 QRUDEWIWKLJBPS-UHFFFAOYSA-N 0.000 description 1
- 239000012964 benzotriazole Substances 0.000 description 1
- 150000001565 benzotriazoles Chemical class 0.000 description 1
- 229910001451 bismuth ion Inorganic materials 0.000 description 1
- 238000004061 bleaching Methods 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000005018 casein Substances 0.000 description 1
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
- 235000021240 caseins Nutrition 0.000 description 1
- 229920002301 cellulose acetate Polymers 0.000 description 1
- ZUIVNYGZFPOXFW-UHFFFAOYSA-N chembl1717603 Chemical compound N1=C(C)C=C(O)N2N=CN=C21 ZUIVNYGZFPOXFW-UHFFFAOYSA-N 0.000 description 1
- 150000001844 chromium Chemical class 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- AFOSIXZFDONLBT-UHFFFAOYSA-N divinyl sulfone Chemical compound C=CS(=O)(=O)C=C AFOSIXZFDONLBT-UHFFFAOYSA-N 0.000 description 1
- 238000007720 emulsion polymerization reaction Methods 0.000 description 1
- OXDLFTCAIITFPZ-UHFFFAOYSA-N formaldehyde;phenylhydrazine Chemical compound O=C.NNC1=CC=CC=C1 OXDLFTCAIITFPZ-UHFFFAOYSA-N 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 229910052737 gold Inorganic materials 0.000 description 1
- 239000010931 gold Substances 0.000 description 1
- 229910052736 halogen Inorganic materials 0.000 description 1
- 150000002367 halogens Chemical class 0.000 description 1
- 150000002391 heterocyclic compounds Chemical class 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 description 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
- 229940046892 lead acetate Drugs 0.000 description 1
- RVPVRDXYQKGNMQ-UHFFFAOYSA-N lead(2+) Chemical compound [Pb+2] RVPVRDXYQKGNMQ-UHFFFAOYSA-N 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000006224 matting agent Substances 0.000 description 1
- 150000002731 mercury compounds Chemical class 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000010981 methylcellulose Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- ZAKLKBFCSHJIRI-UHFFFAOYSA-N mucochloric acid Natural products OC1OC(=O)C(Cl)=C1Cl ZAKLKBFCSHJIRI-UHFFFAOYSA-N 0.000 description 1
- UICBCXONCUFSOI-UHFFFAOYSA-N n'-phenylacetohydrazide Chemical compound CC(=O)NNC1=CC=CC=C1 UICBCXONCUFSOI-UHFFFAOYSA-N 0.000 description 1
- CKLPECFHCLIYKN-UHFFFAOYSA-N n'-phenylbenzohydrazide Chemical compound C=1C=CC=CC=1C(=O)NNC1=CC=CC=C1 CKLPECFHCLIYKN-UHFFFAOYSA-N 0.000 description 1
- UQPFSVMPYHXOFG-UHFFFAOYSA-N n'-phenylmethanesulfonohydrazide Chemical compound CS(=O)(=O)NNC1=CC=CC=C1 UQPFSVMPYHXOFG-UHFFFAOYSA-N 0.000 description 1
- AJDUTMFFZHIJEM-UHFFFAOYSA-N n-(9,10-dioxoanthracen-1-yl)-4-[4-[[4-[4-[(9,10-dioxoanthracen-1-yl)carbamoyl]phenyl]phenyl]diazenyl]phenyl]benzamide Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2NC(=O)C(C=C1)=CC=C1C(C=C1)=CC=C1N=NC(C=C1)=CC=C1C(C=C1)=CC=C1C(=O)NC1=CC=CC2=C1C(=O)C1=CC=CC=C1C2=O AJDUTMFFZHIJEM-UHFFFAOYSA-N 0.000 description 1
- NPKFETRYYSUTEC-UHFFFAOYSA-N n-[2-(4-amino-n-ethyl-3-methylanilino)ethyl]methanesulfonamide Chemical compound CS(=O)(=O)NCCN(CC)C1=CC=C(N)C(C)=C1 NPKFETRYYSUTEC-UHFFFAOYSA-N 0.000 description 1
- WLKXTJOYOZTROF-UHFFFAOYSA-M n-[3-(2-methyl-1,3-benzothiazol-3-ium-3-yl)propylideneamino]aniline;bromide Chemical compound [Br-].CC=1SC2=CC=CC=C2[N+]=1CCC=NNC1=CC=CC=C1 WLKXTJOYOZTROF-UHFFFAOYSA-M 0.000 description 1
- IHKFLZDHIAMCFS-UHFFFAOYSA-N n-[3-(2-methylsulfonylhydrazinyl)phenyl]benzenesulfonamide Chemical compound CS(=O)(=O)NNC1=CC=CC(NS(=O)(=O)C=2C=CC=CC=2)=C1 IHKFLZDHIAMCFS-UHFFFAOYSA-N 0.000 description 1
- PJOHYBFGXHXFGV-UHFFFAOYSA-N n-[4-(2-acetylhydrazinyl)phenyl]acetamide Chemical compound CC(=O)NNC1=CC=C(NC(C)=O)C=C1 PJOHYBFGXHXFGV-UHFFFAOYSA-N 0.000 description 1
- KPUCRHOKIBSYAM-UHFFFAOYSA-N n-[4-[5-(3-ethyl-1,3-benzothiazol-2-ylidene)-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]anilino]formamide Chemical compound S1C2=CC=CC=C2N(CC)C1=C(C1=O)SC(=S)N1C1=CC=C(NNC=O)C=C1 KPUCRHOKIBSYAM-UHFFFAOYSA-N 0.000 description 1
- NAOBJCZMSURSHI-UHFFFAOYSA-N n-[4-[[4-(2-formylhydrazinyl)phenyl]carbamothioylamino]anilino]formamide Chemical compound C1=CC(NNC=O)=CC=C1NC(=S)NC1=CC=C(NNC=O)C=C1 NAOBJCZMSURSHI-UHFFFAOYSA-N 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- QEHKBHWEUPXBCW-UHFFFAOYSA-N nitrogen trichloride Chemical group ClN(Cl)Cl QEHKBHWEUPXBCW-UHFFFAOYSA-N 0.000 description 1
- 229910052762 osmium Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- PNJWIWWMYCMZRO-UHFFFAOYSA-N pentâ4âenâ2âone Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 150000004986 phenylenediamines Chemical class 0.000 description 1
- JOVOSQBPPZZESK-UHFFFAOYSA-N phenylhydrazine hydrochloride Chemical compound Cl.NNC1=CC=CC=C1 JOVOSQBPPZZESK-UHFFFAOYSA-N 0.000 description 1
- 229940038531 phenylhydrazine hydrochloride Drugs 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 1
- 229920000233 poly(alkylene oxides) Polymers 0.000 description 1
- 229920006289 polycarbonate film Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 229920002689 polyvinyl acetate Polymers 0.000 description 1
- 239000011118 polyvinyl acetate Substances 0.000 description 1
- 229920002717 polyvinylpyridine Polymers 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- NDGRWYRVNANFNB-UHFFFAOYSA-N pyrazolidin-3-one Chemical class O=C1CCNN1 NDGRWYRVNANFNB-UHFFFAOYSA-N 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- 229910052703 rhodium Inorganic materials 0.000 description 1
- 239000010948 rhodium Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000008313 sensitization Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- XOKPOPWYLRKXEA-UHFFFAOYSA-N trihexylazanium;chloride Chemical compound Cl.CCCCCCN(CCCCCC)CCCCCC XOKPOPWYLRKXEA-UHFFFAOYSA-N 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000001043 yellow dye Substances 0.000 description 1
- 150000003752 zinc compounds Chemical class 0.000 description 1
Classifications
-
- G—PHYSICS
- G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
- G03C—PHOTOSENSITIVE MATERIALS FOR PHOTOGRAPHIC PURPOSES; PHOTOGRAPHIC PROCESSES, e.g. CINE, X-RAY, COLOUR, STEREO-PHOTOGRAPHIC PROCESSES; AUXILIARY PROCESSES IN PHOTOGRAPHY
- G03C1/00—Photosensitive materials
- G03C1/005—Silver halide emulsions; Preparation thereof; Physical treatment thereof; Incorporation of additives therein
- G03C1/485—Direct positive emulsions
- G03C1/48538—Direct positive emulsions non-prefogged, i.e. fogged after imagewise exposure
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
Description
ïŒç£æ¥äžã®å©çšåéïŒ
æ¬çºæã¯ãçŽæ¥ããžããã²ã³åéåçæå
ææ
ã«é¢ããæŽã«è©³ããã¯ç»åé²å åŸãå šé¢é²å ãäž
ãããããŸãã¯ã«ããªå€ã®ååšäžã«è¡šé¢çŸååŠç
ããããšã«ããçŽæ¥ããžç»åã®åŸãããå éšæœå
åããã²ã³åéä¹³å€å±€ãæããåçææã«é¢ãã
ãã®ã§ããã ïŒåŸæ¥æè¡ïŒ åŸæ¥ç¥ãããŠããçŽæ¥ããžç»åãåŸãæ¹æ³ãšã
ãŠã¯ãäž»ãšããŠïŒã€ã®ã¿ã€ãã«åããããããã®
ïŒã€ã®ã¿ã€ãã¯ããããããã«ããªæ žãæããã
ãã²ã³åéä¹³å€ãçšãããœãŒã©ãªãŒãŒã·ãšã³ãã
ããã¯ããŒã·ãšã«å¹æçãå©çšããŠé²å éšã®ã«ã
ãªæ žãŸãã¯æœåãç Žå£ããããšã«ãã€ãŠãçŸååŸ
ããžç»åãåŸããã®ã§ãããä»ã®ïŒã€ã®ã¿ã€ã
ã¯ãäºãã«ãããããŠããªãå éšæœååããã²ã³
åéä¹³å€ãçšããç»åé²å åŸã«ããªåŠçïŒçŸåæ ž
çæåŠçïŒãæœãã次ãã§è¡šé¢çŸåãè¡ãªããã
ãŸãã¯ç»åé²å åŸã«ããªåŠçïŒçŸåæ žçæåŠçïŒ
ãæœããªããè¡šé¢çŸåãè¡ãªãããšã«ãããããž
ç»åãåŸãããšãã§ãããã®ã§ããã äžèšã®ã«ããªåŠçïŒçŸåæ žçæåŠçïŒã®æ¹æ³
ã¯ãå šé¢é²å ãäžããããšã§ãããããã«ããªå€
ãçšããŠååŠçã«è¡ãªã€ãŠããããããŸã匷åãª
çŸå液ãçšããŠããããããã«ç±åŠççã«ãã€ãŠ
ãããã ããžç»åã圢æããããã®åèšïŒã€ã®æ¹æ³ã®ã
ã¡ãåŸè ã®ã¿ã€ãã®æ¹æ³ã¯ãåè ã®ã¿ã€ãã®æ¹æ³
ã«æ¯èŒããŠãäžè¬çã«æ床ãé«ããé«æ床ãèŠæ±
ãããå¿çšã«é©ããŠããã ãã®æè¡åéã«ãããŠã¯ãçš®ã ã®æè¡ããããŸ
ã§ã«ç¥ãããŠãããäŸãã°ãç±³åœç¹èš±2592250å·ã
å2466957å·ãå2497875å·ãå2588982å·ãå
3761266å·ãå3761276å·ãå3796577å·ããã³è±
åœç¹èš±1151363å·çã«èšèŒãããŠããæ¹æ³ãç¥ã
ããŠããã ãããå ¬ç¥ã®æè¡ãçšããããšã«ãã€ãŠãããž
ç»åã圢æããåçæå ææãäœãããšã¯ã§ãã
ãããããã®åçæå ææãåçš®ã®åçåéã«å¿
çšãããããã«ã¯ããäžå±€ã®åçæ§èœã®æ¹åãå
ã³è£œé äžã®åé¡ç¹ã®è§£æ±ºãæãŸããŠããã äŸãã°ãç±³åœç¹èš±3761276å·åã³å3206313å·ã«
é瀺ãããŠããããã«ããã²ã³åéç²åã®å éšã«
ååŠå¢æãæœããŸãã¯ãå€äŸ¡éå±ã€ãªã³ãããŒã
ããã³ã¢ïŒã·ãšã«åä¹³å€ãçšããããšã«ãã€ãŠã
ãé«ãæ床ãåŸãããšãã§ãããããã®çš®ã®ä¹³å€
ã¯ç»åæ¿åºŠãäœãåãé²å éãé倧ã«ãªããšåã³
ãã¬åãçŸåºãããšããæ¬ ç¹ãæããŠããããŸã
ç±³åœç¹èš±3761276å·ã«ã¯ãäžèšã®ç»åæ¿åºŠãäœã
ãšããæ¬ ç¹ãæ¹è¯ããçºãããã²ã³åéç²åè¡šé¢
ã«ããçšåºŠã®ååŠçæåŠçãæœãããšãé瀺ãã
ãŠããããããã²ã³åéä¹³å€ã®é·æä¿åã«å¯Ÿãã
å®å®æ§ã極ããŠæªãããŸã補é å®å®æ§ãæªããäž
å©ã§ããããŸããç±³åœç¹èš±4395478å·ã¯ãé²å é
ãé倧ã«ãªããšçŸããããã¬åãæå¶ãããã
ã«ãã³ã¢ïŒã·ãšã«åä¹³å€ã®ã·ãšã«éšåã«å€äŸ¡éå±
ã€ãªã³ãå«æãããæè¡ãé瀺ãããŠããããã
ãããŸãããã²ã³åéä¹³å€ã®é·æä¿åã«å¯Ÿããå®
å®æ§ã極ããŠæªããå®çšäžäžéœåã§ããã äžæ¹ãç±³åœç¹èš±2592250å·ã«é瀺ãããŠããå€
æåããã²ã³åéä¹³å€ã¯ãçžå¯Ÿçã«æº¶è§£åºŠã®é«ã
ããã²ã³åéã溶解床ã®äœãããã²ã³åéã«å€æ
ããããšã«ããæ¯èŒç容æã«è£œé ããããšãã§ã
ãããããã«æ床ã®äžæãæäœæ¿åºŠïŒDminïŒã®
æžå°ãæé«æ¿åºŠïŒDmaxïŒã®å¢å€§çåçæ§èœã®æ¹
è¯ãæãŸããŠãããç¹éæ55â127549å·ã§ã¯ãäž
èšã®æ¬ ç¹ãæ¹è¯ããçºãå€æåããã²ã³åéã³ã¢
ã«ããã²ã³åéã·ãšã«ã被èŠããã³ã¢ïŒã·ãšã«æ§
é ãæããããã²ã³åéä¹³å€ãé瀺ãããŠãã
ããçŸå枩床ãäœäžãããšç»åæ¿åºŠã®äœäžã倧ã
ãå®çšäžäžå©ã§ããã çŸå枩床ã®å€åã«å¯Ÿããåçæ§èœã®å®å®æ§ãå
äžãããããã«ããªãµãŒãã»ãã€ã¹ã¯ããŒãžã€ãŒ
ïŒResearch DisclosureïŒNo.15162åã³è±åœç¹èš±
2107074å·ã§ã¯ãéåžçåã®ã«ããªå€ãšåžçåã®
ã«ããªå€ãšã䜵çšããããšãèšèŒãããŠãããã
å åã«ç®çãéããã«ã¯å°ã€ãŠããªãã åŸã€ãŠããã®æ¹åŒã«ããçŽæ¥ããžåçæå ææ
ãå®çšåããçºã«ã¯ãçŸå枩床ã«ããåçæ§èœã®
å€åã®å°ãªããã€ã補é å®å®æ§ãä¿åå®å®æ§ã«åª
ããå éšæœååããã²ã³åéä¹³å€ã®åºçŸãæãŸã
ãã ïŒçºæã®ç®çïŒ åŸã€ãŠæ¬çºæã®ç®çã¯ãçŸå枩床ã®å€åã«å¯Ÿã
ãŠåçæ§èœã®å€åãå°ããããã€ãä¿åå®å®æ§ã
補é å®å®æ§ãåªããçŽæ¥ããžããã²ã³åéåçä¹³
å€ãæäŸããããšã«ããã ãŸããæ¬çºæã®ä»ã®ç®çã¯ããã®ãããªããã²
ã³åéåçä¹³å€ãããªãå±€ãå°ãªããšãäžå±€æ
ããããå®å®ããåçæ§èœãæããããã²ã³åé
åçæå ææãæäŸããããšã«ããã ïŒçºæã®æ§æïŒ åèšæ¬çºæã®ç®çã¯ãå éšæœååããã²ã³åé
ç²åãå«æããããã²ã³åéä¹³å€å±€ãæããé転
çŸåãŸãã¯ç §å°çŸåã«ãã€ãŠããžåç»åãäžãã
ããã²ã³åéåçèŠçŽ ã«æŒãŠã該ããã²ã³åéç²
åãäºããã®è¡šé¢ã«è¡šé¢çŸåæ žãæãããå€æå
ããã²ã³åéç²åãã³ã¢ãšããã³ã¢ïŒã·ãšã«åç²
åã§ãããäžã€è©²ç²åå éšã«å€äŸ¡éå±ã€ãªã³ãå
èµããããšãç¹åŸŽãšããããã²ã³åéåçèŠçŽ ã«
ãã€ãŠéæãããã åèšæ¬çºæã«è¬ãé転çŸåãããã¯ç §å°çŸåãš
ã¯ã倫ã æè¬ãã¶ãå€çã®äœ¿çšã«ããååŠçäœçš
ãããã¯å šé¢å ç §å°çã«ããå ååŠçäœçšã«ãã€
ãŠãæ¢ã«äžããããç»åé²å ã«ãã€ãŠçæããŠã
ãçŸåæ žãšååããŠè©²ç»åé²å éãšéæ¯äŸçã«ç
ããè¡šé¢çŸåæ žã«ããçŸåãè¬ãã æ¬çºæã®å éšæœååããã²ã³åéä¹³å€ã«ããã
å€æåããã²ã³åéã³ã¢ãšã¯ãæ°Žäžã§ã®æº¶è§£åºŠã
èåéãããé«ãå°ãªããšãäžéšã®éå¡©ç²åãã
æãä¹³å€ã圢æããã次ãã§ãããä¹³å€ç²åã®å°
ãªããšãäžéšãèåéãªããæ²èåéã«å€æãã
ããšã«ããäœãããããã²ã³åéç²åã§ãããé
åžžã¯ç¡é žé氎溶液ãšå¡©åç©ã®æ°Žæº¶æ¶²ããŒã©ãã³ç
ã®ä¿è·ã³ãã€ãã®ååšäžã«æ··åããçæããå¡©å
éä¹³å€ã«ãèåç©ã®æ°Žæº¶æ¶²ãæ·»å ããããšã«ãã
容æã«èª¿è£œããããæ¬çºæã«ãããå€æåããã²
ã³åéã³ã¢ç²åã¯å°ãªããšã80ã¢ã«ïŒ ã®èåéã
å«æããŠããããšã奜ãŸããããã€10ã¢ã«ïŒ 以äž
ã®æ²åéãå«æããŠããŠããããç¹ã«å°ãªããšã
90ã¢ã«ïŒ ã®èåéãšïŒã¢ã«ïŒ 以äžïŒïŒã¢ã«ïŒ ãã
å«ãïŒã®æ²åéãå«æããæ®ãã®ããã²ã³åç©ã
å¡©åéã§ããå€æåããã²ã³åéã³ã¢ãæŽã«å¥œãŸ
ããã æ¬çºæã®ã³ã¢ïŒã·ãšã«æ§é ã®ããã²ã³åéç²å
ã¯ãåèšã®å€æåããã²ã³åéã³ã¢ç²åã®è¡šé¢äž
ã«ããã²ã³åéãæ²æŸ±ãããŠããã²ã³åéã·ãšã«
ã圢æããããšã«ãã€ãŠäœãããæ§é ã®ç²åã§ã
ããã·ãšã«ã®ããã²ã³åéã¯å¡©åéãèåéãå¡©
èåéãæ²èåéããã³å¡©æ²èåéã®ããããã
æã€ãŠããŠãããããæ¬çºæã®å®æœæ æ§ã«ãããŠ
å¡©åéãªããã¯èåéã®åäžããã²ã³çµæã®ãã
ã²ã³åéã·ãšã«ãããªã€ãŠããããšã奜ãŸããã æŽã«ãã·ãšã«ã®åãã¯ã³ã¢ïŒã·ãšã«ãæ§æãã
ç·ããã²ã³åéãåºæºãšããŠã·ãšã«ã®ããã²ã³å
ééã30ã¢ã«ïŒ ãªãã50ã¢ã«ïŒ ã§ããã°å åã§ã
ããã·ãšã«ã®ããã²ã³åééã30ã¢ã«ïŒ æªæºã§ã
ããšé«æž©äžã§ã®ä¿åæ§ãæªãæå°æ¿åºŠãå¢å€§ãã
åŸåãçããäžæ¹50ã¢ã«ïŒ ãè¶ ãããšæ倧æ¿åºŠã
äœäžããã æ¬çºæã®å¥œãŸããå®æœæ æ§ã«ãããŠã¯ãããã²
ã³åéã·ãšã«ã圢æãããéã«ãããã©ã¶ã€ã³ã
ã³èªå°äœãå ±åãããããšã奜ãŸãããããã©ã¶
ã€ã³ãã³èªå°äœã¯ãäžè¬ã«ããã²ã³åéä¹³å€ã®å®
å®å€ãšããŠç¥ãããŠãããã®ãçšãããããç¹ã«
äžèšäžè¬åŒ(1)ã§è¡šãããããã®ã奜ãŸããã äžè¬åŒïŒïŒïŒ åŒäžãR1ããã³R2ã¯ããããæ°ŽçŽ ååã眮æ
åºãæããŠãããççŽ ååæ°ïŒããïŒåã®ã¢ã«ã
ã«åºã眮æåºãæããŠãããã¢ãªãŒã«åºãè¡šã
ãããŸãäºãã«çµåããŠïŒå¡ç°ãªããã¯ïŒå¡ç°ã
圢æããŠããããR3ã¯æ°ŽçŽ ååã眮æåºãæã
ãŠãããççŽ ååæ°ïŒããïŒåã®ã¢ã«ãã«åºãŸã
ã¯çœ®æåºãæããŠãããã¢ãªãŒã«åºãè¡šããã å ·äœçã«ã¯æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã®è¡š
é¢æ床ãã§ããã ãäœãæããããäœãæå°æ¿
床ãããå®å®ãªç¹æ§ãéäžããããããã«ãåèš
äžè¬åŒ(1)ã§è¡šããããå®å®å€ãäŸãã°ã¢ã¶ã€ã³ã
ã³ç°ãæã€ååç©ããã³ã¡ã«ã«ãããæããè€çŽ
ç°åŒååç©ïŒä»£è¡šçãªãã®ãšããŠããããïŒâã
ãããã·âïŒâã¡ãã«âïŒïŒïŒïŒ3aïŒïŒâãã
ã©ã¶ã€ã³ãã³ããã³ïŒâããšãã«âïŒâã¡ã«ã«ã
ãããã©ãŸãŒã«ãæããããŠãããïŒãå«æãã
ãããšãã§ããã ãã®ä»æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã«ã¯ãã
ã¶ãé²æ¢å€ãŸãã¯å®å®å€ãšããŠãäŸãã°æ°Žéåå
ç©ãããªã¢ãŸãŒã«ç³»ååç©ãã¢ã¶ã€ã³ãã³ç³»åå
ç©ããã³ãŸãã¢ãŸãªãŠã ç³»ååç©ãäºéååç©ç
ã䜿çšãåŸãã æ¬çºæã«ãããå éšæœååããã²ã³åéç²å
ã¯ãå€äŸ¡éå±ã€ãªã³ãç²åå éšã«åžèµããŠããã
ãã®ãããªããã²ã³åéä¹³å€ã¯ãããã²ã³åéç²
åã®åœ¢æåã«ãéå±ã€ãªã³ãåå¿å®¹åšäžã«å°å ¥ã
ããããããã¯ããã²ã³åéç²åã®æé·äžãåã¯
çé·ãäžæããŠããæã§æé·çµäºãã以åã®ãã
ããã®æ®µéã«ãããŠãåå¿å®¹åšäžã«å°å ¥ããããš
ã«ãã€ãŠåŸãããšãã§ãããå ·äœçã«è¿°ã¹ããªã
ã°ãå€äŸ¡éå±ã€ãªã³ã¯ãããã²ã³åéç²åã®åœ¢æ
åã«ãåã¯ãå€æãããã¹ãããã²ã³åéç²åã®
圢æäžãããã¯åœ¢æåŸã«ãåã¯å€æã®çºã®æ°Žæº¶æ§
ããã²ã³åç©ã®æ·»å äžã«ããŸãã¯å€æåŸãããã²
ã³åéã·ãšã«ã®åœ¢åŒãçµäºãã以åã«åå¿å®¹åšäž
ã«æ·»å ããããšãã§ããããæ¬çºæã®å®æœæ æ§ã«
ãããŠã¯ãããã²ã³åéã·ãšã«ã®2/3ãã圢æã
çµäºãã以åã«æ·»å ãããã®ã奜ãŸããã æ¬çºæã«ãããå€äŸ¡éå±ã€ãªã³ã®ïŒã€ã®å¥œãŸã
ãå ·äœäŸãšããŠã¯ãã€ãªãžãŠã ã€ãªã³ããããé
ïŒã¢ã«ã«å¯Ÿãã10-9ã10-3ã¢ã«ã®æ¿åºŠã§äœ¿çšãã
ã®ã奜ãŸãããããã«å¥œãŸããã¯ã10-8ã10-5ã¢
ã«ã®æ¿åºŠã§äœ¿çšãããã€ãªãžãŠã ã¯æ°Žæº¶æ§å¡©ãšã
ãŠãäŸãã°ã«ãªãŠã ãããµã¯ããã€ãªããŒããã
ããã¯ãããµããã¢ã€ãªããŒããšããŠæ·»å ããã
ããã²ã³åéç²åå ã«çµã¿èŸŒãŸããã æ¬çºæã«ãããå€äŸ¡éå±ã€ãªã³ã®ä»ã®ïŒã€ã®å¥œ
ãŸããå ·äœäŸãšããŠã¯éã€ãªã³ããããéã€ãªã³
ã¯ã氎溶æ§å¡©ãäŸãã°é ¢é žéãç¡é žéçã®åœ¢æ ã§
奜ãŸããã¯ãAg1ã¢ã«ã«å¯Ÿãã10-6ã10-2ã®æ¿åºŠ
ã§æ·»å ãããããã²ã³åéç²åå éšã«çµèŸŒãŸã
ãã æ¬çºæã«ãããå€äŸ¡éå±ã€ãªã³ã®ããã«å¥ã®å¥œ
ãŸããå ·äœäŸãšããŠã¯ãã¢ã³ãã¢ã³ã€ãªã³ããã¹
ãã¹ã€ãªã³ãéã€ãªã³ãçœéã€ãªã³ããªã¹ããŠã
ã€ãªã³ãããžãŠã ã€ãªã³çãããããããã®å€äŸ¡
éå±ã€ãªã³ã¯ã奜ãŸããã¯éïŒã¢ã«ã«å¯Ÿã10-9ã
10-4ã¢ã«ã®æ¿åºŠã§äœ¿çšãããã æ¬çºæã®å éšæœååããã²ã³åéç²åã¯ãç²å
è¡šé¢ãååŠçã«å¢æãããŠããªããããããã¯å¢
æãããŠããŠãå ããªçšåºŠã§ããããšã奜ãŸã
ãã ç²åè¡šé¢ãäºããã®è¡šé¢ã®è¡šé¢çŸåæ žãæããª
ããšããæå³ã¯ãæ¬çºæã«äœ¿çšãããä¹³å€ãéæ
ãªãã€ã«ã æ¯æäœäžã«35mgAgïŒcm2ã«ãªãããã«
å¡åžããè©Šéšçãé²å ããã«äžèšè¡šé¢çŸå液ã§
20âã§10åéçŸåããå Žåã«åŸãããæ¿åºŠã0.6
奜ãŸããã¯0.4ãè¶ããªãããšãããã è¡šé¢çŸå液 ã¡ããŒã« 2.5ïœ ïœâã¢ã¹ã³ã«ãã³é ž 10 ïœ NaBO2ã»4H2 35 ïœ KBr ïŒ ïœ æ°Žãå ããŠ ïŒ ãŸããæ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã¯ãäžèš
ã®ããã«ããŠäœæããè©Šéšçãé²å åŸãäžèšåŠæ¹
ã®å éšçŸå液ã§çŸåããå Žåã«ååãªæ¿åºŠãäž
ãããã®ã§ããã å éšçŸå液 ã¡ããŒã« ïŒ ïœ äºç¡«é žãœãŒãïŒç¡æ°ŽïŒ 90 ïœ ãã€ããããã³ ïŒ ïœ çé žãœãŒãïŒäžæ°Žå¡©ïŒ 52.5 ïœ KBr ïŒ ïœ KI 0.5 ïœ æ°Žãå ããŠ ïŒ æŽã«å ·äœçã«è¿°ã¹ããªãã°ãåèšè©²è©Šéšçã®äž
éšãçŽïŒç§ãŸã§ã®ããå®ããããæéã«ããã€ãŠ
å 匷床ã¹ã±ãŒã«ã«é²å ããå éšçŸå液ã§20âã§
ïŒåéçŸåããå Žåã«ãåäžæ¡ä»¶ã§é²å ãã該詊
éšçã®å¥ã®äžéšãè¡šé¢çŸå液ã§20âã§ïŒåéçŸ
åããå Žåã«åŸããããã®ãããå°ãªããšãïŒ
åã奜ãŸããã¯å°ãªããšã10åã®æ倧æ¿åºŠã瀺ã
ãã®ã§ããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã¯éåžžçšããã
ãå¢æè²çŽ ã«ãã€ãŠå åŠçã«å¢æããããšãã§ã
ããå éšæœååããã²ã³åéä¹³å€ããã¬åããã²
ã³åéä¹³å€çã®è¶ è²å¢æã«çšããããå¢æè²çŽ ã®
çµåãã¯æ¬çºæã®ããã²ã³åéä¹³å€ã«å¯ŸããŠãæ
çšã§ãããå¢æè²çŽ ã«ã€ããŠã¯ãªãµãŒãã»ãã€ã¹
ã¯ããŒãžã€ãŒïŒReseach DisclosureïŒNo.15162ã
åç §ããããšãã§ããã æ¬çºæã®åçæå èŠçŽ ãæããåçæå ææ
ïŒä»¥åŸåçææãšç§°ããïŒã¯æ®éã®æ¹æ³ã§æ®åœ±ã
ãåŸã«ãè¡šé¢çŸåããããšã«ãã€ãŠå®¹æã«çŽæ¥ã
ãžç»åãåŸãããšãã§ãããå³ã¡çŽæ¥ããžç»åã
äœæããäž»èŠãªå·¥çšã¯ãæ¬çºæã®è¡šé¢çŸåæ žãæ
ããªãå éšæœååããã²ã³åéä¹³å€å±€ãæããå
çææããç»åé²å åŸååŠçäœçšãããã¯å ååŠ
çäœçšã«ãã€ãŠè¡šé¢çŸåæ žãçæããåŠçïŒä»¥åŸ
ã«ããªåŠçãšç§°ãïŒãæœããåŸã§ããã³ïŒãŸãã¯
ã«ããªåŠçãæœããªããè¡šé¢çŸåãè¡ãªãããšã
ããªããããã§ã«ããªåŠçã¯ãå šé¢é²å ãäžãã
ããããã¯è¡šé¢çŸåæ žãçæããååç©ïŒä»¥åŸã«
ããªå€ãšç§°ãïŒãçšããŠè¡ãªãããšãã§ããã æ¬çºæã«æŒããŠãå šé¢é²å ã¯ç»åé²å ããæå
ææãçŸå液ãããã¯ãã®ä»ã®æ°Žæº¶æ¶²ã«æµžæŒ¬ãã
ããŸãã¯æ¹¿æœ€ãããåŸãå šé¢çã«åäžé²å ããã
ãšã«ãã€ãŠè¡ãªããããããã§äœ¿çšããå æºãšã
ãŠã¯åçææã®æå æ³¢é·åå ã®å ã§ããã°ããã
ã§ããããåãã©ãã·ãŠå ã®ããšãé«ç §åºŠå ãç
æéããŠãããšãã§ãããããŸãã¯åŒ±ãå ãé·æ
éããŠããããããŸãå šé¢é²å ã®æéã¯åçæ
æãçŸååŠçæ¡ä»¶ã䜿çšããå æºã®çš®é¡çã«ã
ããæçµçã«æè¯ã®ããžç»åãåŸãããããåºç¯
å²ã«å€ããããšãã§ããã è¯å¥œãªããžç»ãåŸããããããªå šé¢é²å ã®ç §åºŠ
ããã³é²å æéã®ç¯å²ãéžè±ããæ¡ä»¶ã§å šé¢é²å
ãè¡ãªããšãåŸãããããžç»åã®ç»è³ªã¯å£åã
ããäŸãã°é床ã«é«ãç §åºŠã®å šé¢é²å ãè¡ãªã
ãšãç»åã®æé«æ¿åºŠã¯äœäžããæäœæ¿åºŠã¯äžæã
ããåé床ã«äœãç §åºŠã®å šé¢é²å ãè¡ãªããšæé«
æ¿åºŠã®äœãç»åããåŸãããªããè¯å¥œãªç»åãäž
ããããšã®ã§ããå šé¢é²å ã®èš±å®¹å¹ ã¯ãæ¬çºæã®
ããã²ã³åéä¹³å€ã䜿çšããããšã«ãã€ãŠæ¡å€§ã
ããã€ãŸããæ¬çºæã®ããã²ã³åéä¹³å€ã䜿çšã
ãã°ããé«ãç §åºŠã§ãæå°æ¿åºŠãäžæããããã
äœãç §åºŠã§ãååãªæé«æ¿åºŠãåŸãããã æ¬çºæã«ãããŠäœ¿çšããã«ããªå€ãšããŠã¯åºç¯
å²ãªçš®é¡ã®ååç©ãçšããããšãã§ãããã®ã«ã
ãªå€ã¯çŸååŠçæã«ååšããã°ãããäŸãã°ãå
çææã®æ¯æäœä»¥å€ã®æ§æå±€äžïŒãã®äžã§ãç¹ã«
ããã²ã³åéä¹³å€å±€äžã奜ãŸããïŒããããã¯çŸ
å液ãããã¯çŸååŠçã«å ç«ã€åŠç液ã«å«æãã
ããŠãããããŸããã®äœ¿çšéã¯ç®çã«å¿ããŠåºç¯
å²ã«å€ããããšãã§ãã奜ãŸããæ·»å éãšããŠ
ã¯ãããã²ã³åéä¹³å€å±€äžã«æ·»å ãããšãã¯ãã
ãã²ã³åéïŒã¢ã«åœãïŒã1500mgã奜ãŸããã¯10
ã1000mgã§ããããŸããçŸå液çã®åŠç液ã«æ·»å
ãããšãã®å¥œãŸããæ·»å éã¯0.01ãïŒïœïŒãç¹
ã«å¥œãŸããã¯0.05ãïŒïœïŒã§ããã æ¬çºæã«çšããã«ããªå€ãšããŠã¯ãäŸãã°ç±³åœ
ç¹èš±2563785å·ãå2588982å·ã«èšèŒãããŠããã
ãã©ãžã³é¡ããããã¯ç±³åœç¹èš±3227552å·ã«èšèŒ
ãããããã©ãžããŸãã¯ããã©ãŸã³ååç©ïŒç±³åœ
ç¹èš±3615615å·ãå3718470å·ãå3719494å·ãå
3734738å·ããã³å3759901å·ã«èšèŒãããè€çŽ ç°
第ïŒçŽçªçŽ å¡©åååç©ïŒæŽã«ç±³åœç¹èš±4030925å·
èšèŒã®ã¢ã·ã«ããã©ãžãããšãã«ããªå°¿çŽ é¡ã®åŠ
ããããã²ã³åéè¡šé¢ãžã®åžçåºãæããååç©
ãæããããããŸãããããã®ã«ããªå€ã¯çµåã
ãŠçšããããšãã§ãããäŸãã°ãªãµãŒãã»ãã€ã¹
ã¯ããŒãžã€ãŒïŒReseach DisclosureïŒNo.15162ã«
ã¯éåžçåã®ã«ããªå€ãåžçåã®ã«ããªå€ãšäœµçš
ããããšãèšèŒãããŠããã æ¬çºæã«çšããã«ããªå€ãšããŠã¯ãåžçåãé
åžçåã®ãã¥ãã䜿çšããããšãã§ãããããã
ãã䜵çšããŠäœ¿çšããããšãã§ããããæ¬çºæã®
ïŒã€ã®å¥œãŸããå®æœæ æ§ã«ãããŠã¯ãå°ãªããšã
äžçš®ã®åžçåã®ã«ããªå€ã䜿çšãããã éåžžãçŸåæã«ã«ããªå€ãéå°ã«ååšãããšã
æ床ã®äœäžãæäœæ¿åºŠã®äžæãåŒããããå Žåã
ããããæ¬çºæã®ä¹³å€ãçšããå Žåãã«ããªå€é
ã«å¯Ÿãã蚱容床ã¯åºããã æçšãªã«ããªå€ã®å ·äœäŸã瀺ãã°ãããã©ãžã³
å¡©é žå¡©ãããšãã«ããã©ãžã³å¡©é žå¡©ãïŒâã¡ãã«
ããšãã«ããã©ãžã³å¡©é žå¡©ãïŒâãã«ãã«âïŒâ
ïŒïŒâã¡ãã«ããšãã«ïŒããã©ãžã³ãïŒâã¢ã»ã
ã«âïŒâããšãã«ããã©ãžã³ãïŒâã¢ã»ãã«âïŒ
âïŒïŒâã¢ã»ãã¢ããããšãã«ïŒããã©ãžã³ãïŒ
âã¡ãã«ã¹ã«ããªãã«âïŒâããšãã«ããã©ãž
ã³ãïŒâãã³ãŸã€ã«âïŒâããšãã«ããã©ãžã³ã
ïŒâã¡ãã«ã¹ã«ããªãã«âïŒâïŒïŒâããšãã«ã¹
ã«ããªã³ã¢ããããšãã«ïŒããã©ãžã³ãããªã«ã
ã¢ã«ãããããšãã«ããã©ãžã³çã®ããã©ãžã³å
åç©ïŒïŒâïŒïŒâãã«ãã«ãšãã«ïŒâïŒâã¡ãã«ã
ã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒâïŒïŒâãã«ã
ã«ãšãã«ïŒâïŒâãããã«ãã³ãŸãã¢ãŸãªãŠã ã
ããã€ããïŒâïŒïŒâã¢ã»ãã«ãšãã«ïŒâïŒâãã³
ãžã«ãã³ãŸã»ã¬ããŸãªãŠã ãããã€ããïŒâïŒïŒ
âã¢ã»ãã«ãšãã«âïŒâãã³ãžã«âïŒâããšãã«
âãã³ãŸãªããµãŸãªãŠã ãããã€ããïŒâã¡ãã«
âïŒâãïŒâïŒããšãã«ããã©ãŸãïŒãããã«ãã
ã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒâã¡ãã«âïŒâ
ãïŒâïŒïœâããªã«ããã©ãŸãïŒãããã«ããã³ãŸ
ãã¢ãŸãªãŠã ãããã€ããïŒâã¡ãã«âïŒâãïŒ
âïŒïœâã¹ã«ããªããšãã«ããã©ãŸãïŒãããã«ã
ãã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒâã¡ãã«âïŒ
âãïŒâïŒïœâã¹ã«ããªããšãã«ããã©ãŸãïŒãã³
ãã«ããã³ãŸãã¢ãŸãªãŠã ãšãŒãããïŒïŒïŒâãž
ãããâïŒâã¡ãã«âïŒâããšãã«ããªããïŒïŒ
ïŒâïœããã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒïŒïŒ
âãžãããâïŒâã¡ãã«âïŒâããšãã«ããªã
ãïŒïŒïŒâïœãâïŒâããšãã«ãã³ãŸãªããµãŸãªãŠ
ã ãããã€ããïŒïŒïŒâãšãã¬ã³ãã¹ïŒïŒïŒïŒâ
ãžãããâïŒâã¡ãã«ããªããïŒïŒïŒâïœããã³
ãŸãã¢ãŸãªãŠã ãããã€ãïŒãïŒïŒïŒâãžããã
âïŒâã¡ãã«âïŒâããšãã«ããªããïŒïŒïŒâ
ïœããã³ãŸã»ã¬ããŸãªãŠã ãããã€ãçã®ïŒ®â眮
æ第ïŒçŽã·ã¯ãã¢ã³ã¢ããŠã å¡©ïŒïŒâãïŒâãšã
ã«ãããïŒïŒïŒïŒâïœïŒãã¢ãŸãªã³âïŒâã€ãªã
ã³ãšããªãã³ãâïŒâïŒïŒâããšãã«ã«ã«ããŸã€
ã«ïŒã¡ãã«âïŒâïŒïŒâã¹ã«ãã¢ã¢ã€ã«ããšãã«ïŒ
âïŒâããªããã³ãã€ã³ãïŒâïŒïŒâãšãã«âïŒ
âãã³ãŸãã¢ãŸãªããªãã³ïŒâïŒâãïŒâïŒïŒâã
ãªã«ãã«ããã©ãžãïŒããšãã«ãããŒããã³ãïŒ
âãïŒâïŒïŒâããªã«ãã«ããã©ãžãïŒããšãã«ã
ïŒâããšãã«ããªå°¿çŽ ãïŒïŒïŒâãã¹ãïŒâïŒïŒ
âããªã«ãã«ããã©ãžãïŒããšãã«ãããªå°¿çŽ ãª
ã©ãæããããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€å±€ãæããåç
ææã¯åæ§é²å åŸãå šé¢é²å ããããŸãã¯ã«ããª
å€ã®ååšäžã«çŸååŠçããããšã«ãã€ãŠçŽæ¥ããž
ç»åã圢æãããæ¬çºæã«ä¿ãåçææã®çŸååŠ
çæ¹æ³ã¯ä»»æã®çŸååŠçæ¹æ³ãæ¡çšããããã奜
ãŸããã¯è¡šé¢çŸååŠçæ¹æ³ã§ããããã®è¡šé¢çŸå
åŠçæ¹æ³ãšã¯ããã²ã³åé溶å€ãå®è³ªçã«å«ãŸãª
ãçŸå液ã§åŠçããããšãæå³ããã æ¬çºæã«ä¿ãåçææã®çŸåã«çšããçŸå液ã«
ãããŠäœ¿çšããããšã®ã§ããçŸåå€ãšããŠã¯ãé
åžžã®ããã²ã³åéçŸåå€ãäŸãã°ãã€ããããã³
ã®åŠãããªããããã·ãã³ãŒã³é¡ãã¢ããããšã
ãŒã«é¡ãïŒâãã©ãŸãªãã³é¡ãã¢ã¹ã³ã«ãã³é žãš
ãã®èªå°äœãã¬ãã¯ãã³é¡ãããšãã¬ã³ãžã¢ãã³
é¡çãããã¯ãã®æ··åç©ãå«ãŸãããå ·äœçã«ã¯
ãã€ããããã³ãã¢ããããšããŒã«ãâã¡ãã«
ã¢ããããšããŒã«ãïŒâããšãã«âïŒâãã©ãŸãª
ãã³ãïŒâããšãã«âïŒïŒïŒâãžã¡ãã«âïŒâã
ã©ãŸãªãã³ãïŒâããšãã«âïŒâã¡ãã«âïŒâã
ãããã·ã¡ãã«âïŒâãã©ãŸãªãã³ãã¢ã¹ã³ã«ã
ã³é žãïŒïŒ®âãžãšãã«âïœâããšãã¬ã³ãžã¢ã
ã³ããžãšãã«ã¢ããâïœâãã«ã€ãžã³ãïŒâã¢ã
ãâïŒâã¡ãã«ââãšãã«ââïŒÎ²âã¡ã¿ã³
ã¹ã«ããªã³ã¢ãããšãã«ïŒã¢ããªã³ãïŒâã¢ãã
âïŒâã¡ãã«ââãšãã«ââïŒÎ²âãããã
ã·ãšãã«ïŒã¢ããªã³çãæããããããããã®çŸ
åå€ã¯ãããããä¹³å€äžã«å«ãŸããŠãããé«PHæ°Ž
溶液浞挬äžã«ããã²ã³åéã«äœçšãããããã«ã
ãããšãã§ããã æ¬çºæã«ãããŠäœ¿çšãããçŸå液ã¯ãæŽã«ç¹å®
ã®ãã¶ãé²æ¢å€åã³çŸåæå¶å€ãå«æããããšã
ã§ãããããã¯ãããã®çŸå液添å å€ãåçææ
ã®æ§æå±€äžã«ä»»æã«çµã¿å ¥ããããšãå¯èœã§ã
ããéåžžæçšãªãã¶ãé²æ¢å€ã«ã¯ããã³ãŸããªã¢
ãŸãŒã«é¡äŸãã°ïŒâã¡ãã«ãã³ãŸããªã¢ãŸãŒã«ã
ãã³ãã€ãããŸãŒã«é¡ããã³ãŸãã¢ãŸãŒã«é¡ãã
ã³ãŸãªããµãŸãŒã«é¡ãïŒâããšãã«âïŒâã¡ã«ã«
ããããã©ãŸãŒã«ã®ãããªè€çŽ ç°åŒããªã³é¡ãè³
éŠæåã³èèªæã®ã¡ã«ã«ããååç©çãå«ãŸã
ãããŸããçŸå液äžã«ã¯çŸåä¿é²å€äŸãã°ããªã¢
ã«ãã¬ã³ãªããµã€ãèªå°äœã第ïŒçŽã¢ã³ã¢ããŠã
å¡©ååç©ãªã©ãå«æãããããšãã§ããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã«ã¯ãåçš®ã®å
ççšæ·»å å€ãå ããããšã¯ä»»æã§ããã ãã®ä»æ¬çºæã«ãããŠãç®çã«å¿ããŠçšããã
ãæ·»å å€ã¯ã湿最å€ãšããŠã¯ãäŸãã°ããžããã
ãã·ã¢ã«ã«ã³çãæããããããã«èç©æ§æ¹è¯å€
ãšããŠã¯ãäŸãã°ãã¢ã«ãã«ã¢ã¯ãªã¬ãŒãããã
ã¯ã¢ã«ãã«ã¡ã¿ã¢ã¯ãªã¬ãŒããšã¢ã¯ãªã«é žããã
ã¯ã¡ã¿ã¢ã¯ãªã«é žãšã®å ±éåäœãã¹ãã¬ã³âãã¬
ã€ã³é žå ±éåäœãã¹ãã¬ã³ç¡æ°Žãã¬ã€ã³é žããŒã
ã¢ã«ãã«ãšã¹ãã«å ±éåäœçã®ä¹³åéåã«ãã€ãŠ
åŸãããæ°Žåæ£æ§ã®åŸ®ç²åç¶é«ååç©è³ªçãé©åœ
ã§ãããå¡åžå©å€ãšããŠã¯ãäŸãã°ããµããã³ã
ããªãšãã¬ã³ã°ãªã³ãŒã«ã©ãŠãªã«ãšãŒãã«çãå«
ãŸããããã®ä»åççšæ·»å å€ãšããŠããŒã©ãã³å¯
å¡å€ãçé¢æŽ»æ§å€ã玫å€ç·åžåå€ãPH調æŽå€ãé ž
åé²æ¢å€ã垯é»é²æ¢å€ãå¢ç²å€ãç²ç¶æ§åäžå€ã
ææãã¢ã«ãã³ããå¢çœå€ãçŸåé床調ç¯å€ãã
ããå€çã䜿çšããããšã¯ä»»æã§ããã äžè¿°ã®åŠã調æŽãããããã²ã³åéä¹³å€ã¯ãå¿
èŠã«å¿ããŠäžåŒå±€ããã¬ãŒã·ãšã³é²æ¢å±€ããã€ã«
ã¿ãŒå±€çãä»ããŠæ¯æäœã«å¡åžããå éšæœååã
ãã²ã³åéåçææãåŸãã æ¬çºæã«ä¿ãåçææãã«ã©ãŒçšã«é©çšããã
ãšã¯æçšã§ããããã®å Žåããã²ã³åéåçä¹³å€
äžã«ã·ã¢ã³ãããŒã³ã¿ããã³ã€ãšããŒã®è²çŽ å圢
æã«ãã©ãŒãå«ãŸããããšã奜ãŸãããã«ãã©ãŒ
ãšããŠã¯éåžžçšãããããã®ã䜿çšã§ããã ãŸããè²çŽ ç»åã®çæ³¢é·ã®æŽ»æ§å ç·ã«ããè€è²
ãé²æ¢ãããã玫å€ç·åžåå€ãäŸãã°ãã¢ãŸãªã
ã³ããã³ãŸããªã¢ãŸãŒã«ãã¢ã¯ãªããããªã«ãã
ã³ãŸããšãã³ç³»ååç©ãçšããããšã¯æçšã§ã
ããç¹ã«ãããã³PSãå320ãå326ãå327ãå
328ïŒããããããã¬ã€ã®ãŒç€Ÿè£œïŒã®åçšãããã¯
䜵çšãæå©ã§ããã æ¬çºæã«ä¿ãåçæå ææã®æ¯æäœãšããŠã¯ä»»
æã®ãã®ãçšãããããã代衚çãªæ¯æäœãšããŠ
ã¯ãå¿ èŠã«å¿ããŠäžåŒå å·¥ããããªãšãã¬ã³ãã¬
ãã¿ã¬ãŒããã€ã«ã ãããªã«ãŒãããŒããã€ã«
ã ãããªã¹ãã¬ã³ãã€ã«ã ãããªãããã¬ã³ãã€
ã«ã ãã»ã«ããŒãºã¢ã»ããŒããã€ã«ã ãã¬ã©ã¹ã
ãã©ã€ã¿çŽãããªãšãã¬ã³ã©ãããŒãçŽçãå«ãŸ
ããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã«ã¯ä¿è·ã³ãã€
ããããã¯çµåå€ãšããŠãŒã©ãã³ã®ä»ã«ç®çã«å¿
ããŠé©åœãªãŒã©ãã³èªå°äœãçšããããšãã§ã
ãããã®é©åœãªãŒã©ãã³èªå°äœãšããŠã¯ãäŸã
ã°ãã¢ã·ã«åãŒã©ãã³ãã°ã¢ããžã«åãŒã©ãã³ã
ã«ã«ããã«åãŒã©ãã³ãã·ã¢ããšã¿ããŒã«åãŒã©
ãã³ããšã¹ãã«åãŒã©ãã³çãæããããšãã§ã
ãã ãŸããæ¬çºæã«ãããŠã¯ãç®çã«å¿ããŠä»ã®èŠª
æ°Žæ§çµåå€ãå«ãŸããããšãã§ãããã®é©åœãªçµ
åå€ãšããŠã¯ãŒã©ãã³ã®ã»ããã³ãã€ãç¶ã¢ã«ã
ãã³ãå¯å€©ãã¢ã©ãã¢ãŽã ãããã¹ãã©ã³ãã¢ã«
ã®ã³é žãã¢ã»ãã«å«æ19ã20ïŒ ã«ãŸã§å æ°Žå解ã
ããã»ã«ããŒãºã¢ã»ããŒãã®åŠãã»ã«ããŒãºèªå°
äœãããªã¢ã¯ãªã«ã¢ãããã€ããåããªã¢ã¯ãªã«
ã¢ãããã«ãŒã€ã³ãããã«ã¢ã«ã³ãŒã«âããã«ã¢
ããã¢ã»ããŒãã³ããªããŒã®åŠããŠã¬ã¿ã³ã«ã«ã
ã³é žåºãŸãã¯ãã·ã¢ãã¢ã»ãã«åºãå«ãããã«ã¢
ã«ã³ãŒã«ããªããŒãããªããã«ã¢ã«ã³ãŒã«ãããª
ããã«ãããªãã³ãå æ°Žå解ããªããã«ã¢ã»ããŒ
ããèçœè³ªãŸãã¯é£œåã¢ã·ã«åèçœè³ªãšããã«åº
ãæããã¢ãããŒãšã®éåã§åŸãããããªããŒã
ããªããã«ããªãžã³ãããªããã«ã¢ãã³ãããªã¢
ãããšãã«ã¡ã¿ã¢ã¯ãªã¬ãŒããããªãšãã¬ã³ã¢ã
ã³çãå«ãŸããä¹³å€å±€ãããã¯äžéå±€ãä¿è·å±€ã
ãã€ã«ã¿ãŒå±€ãè£åŒå±€çã®åçæææ§æå±€ã«ç®ç
ã«å¿ããŠæ·»å ããããšãã§ããããã«äžèšèŠªæ°Žæ§
ãã€ã³ããŒã«ã¯ç®çã«å¿ããŠé©åœãªå¯å¡å€ã最æ»
å€çãå«æããããããšãã§ããã ãŸããæ¬çºæã«ä¿ãåçææã®æ§æå±€ã¯ä»»æã®
é©åœãªç¡¬èå€ã§ç¡¬åããããããšãã§ããããã
ãã®ç¡¬èå€ãšããŠã¯ãã¯ãã å¡©ããžã«ã³ããŠã
é¡ãããªã«ã ã¢ã«ããããã ã³ããã²ã³é žã®åŠã
ã¢ã«ãããç³»ãããããªã¢ãžã³ç³»ãããªãšããã·
ååç©ããšãã¬ã³ã€ãã³ç³»ãããã«ã¹ã«ããªã³
ç³»ãã¢ã¯ãªãã€ã«ç³»ç¡¬èå€çãæããããã ãŸããæ¬çºæã«ä¿ãåçææã¯ãæ¯æäœäžã«ä¹³
å€å±€ããã€ã«ã¿ãŒå±€ãäžéå±€ãä¿è·å±€ãäžåŒå±€ã
è£åŒå±€ããã¬ãŒã·ãšã³é²æ¢å±€çã®çš®ã ã®åçæ§æ
å±€ãå€æ°èšçœ®ããããšãå¯èœã§ããã æ¬çºæã«ä¿ãåçææã¯ãçœé»äžè¬çšãã¬ã€
çšãã«ã©ãŒçšãåœã«ã©ãŒçšãå°å·çšãèµ€å€çšãã
ã€ã¯ãçšãéè²çŽ æŒçœçšçã®çš®ã ã®çšéã«æå¹ã«
é©çšããããšãã§ãããŸããã³ãã€ã転åæ³ãé
å¡©æ¡æ£è»¢åæ³ãããžã€ãŒã¹ã®ç±³åœç¹èš±3087817å·ã
å3185567å·åã³å2983606å·ããŠãšã€ã€ãŒããã®
ç±³åœç¹èš±3253915å·ããã¯ã€ãã¢ã¢ãã®ç±³åœç¹èš±
3227550å·ãããŒã«ãã®ç±³åœç¹èš±3227551å·ããã¯
ã€ãã¢ã¢ã®ç±³åœç¹èš±3227552å·ããã³ã©ã³ãã®ç±³
åœç¹èš±3415644å·ãå3415645å·ããã³å3415646
å·ã«èšèŒãããŠãããããªã«ã©ãŒç»å転åæ³ãã«
ã©ãŒæ¡æ£è»¢åæ³ãåžå転åæ³çã«ãé©çšã§ããã ïŒçºæã®å¹æïŒ æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ãçšããããšã«
ãããçŸå枩床ãå€åããŠããåçæ§èœã®å€åã
å°ãªãå®å®ãªããã²ã³åéåçæå ææãåŸã
ãããã€ã該æå ææãé·æã«ããã€ãŠä¿åããŠ
ãããã®åçæ§èœãå®å®ããŠããããã²ã³åéå
çæå ææãã容æã«è£œé ããããšãã§ããããŸ
ããã®åªããæ§èœã¯ãå€æåã³ã¢ãšãããã被èŠ
ããããã²ã³åéã·ãšã«ãšã«ããã³ã¢ïŒã·ãšã«æ§
é ã®ç¹æ§åã³åžèµãããå€äŸ¡éå±ã€ãªã³ã®ç¹æ§
ããçžè£çã«äœçšããŠçŸåºããŠãããã®ãšèãã
ããã ïŒå®æœäŸïŒ 以äžãå®æœäŸããããŠæ¬çºæãäŸèšŒããããæ¬
çºæã®å®æœã®æ æ§ãããã«ãã€ãŠéå®ããããã®
ã§ã¯ãªãã æ¯èŒäŸ ïŒ ç¹éæ47â32813å·ã®å®æœäŸâïŒã«èšèŒãããŠ
ããæ¹æ³ã«åŸã€ãŠæ²èåéä¹³å€ïŒæ²åç©2.5ã¢ã«
ïŒ ïŒã調補ãããããªãã¡ãéïŒã¢ã«åœãïŒå¡©å
ã€ãªãžãŠã é žã«ãªãŠã 10.7mgãå«æããè¿ éã«æª
æããããŒã©ãã³æ°Žæº¶æ¶²ã«å¯ŸããŠãç¡é žé氎溶液
åã³èåã«ãªãŠã ãšæ²åã«ãªãŠã ã®æ°Žæº¶æ¶²ãåæ
ã«å ããããã®éãæ²æŸ±ã¯é žæ§åªäœäžã«ãããŠã
pAg8.9ã§ãã€ãŠ70â60åéã«ããã€ãŠè¡ãªã€ãã
ãã®åŸæ°ŽæŽãè¡ãªã€ãŠæ°Žæº¶æ§ãã©ã€ããé€å»ãã
åŸããŒã©ãã³ãå ããããã®åŸãããä¹³å€ãä¹³å€
âãšããã æ¯èŒäŸ ïŒ ç¹å ¬æ52â34213å·ã«èšèŒãããŠããå®æœäŸïŒ
ã«åŸã€ãŠããã²ã³åéä¹³å€ã調補ãããããªã
ã¡ããŒã©ãã³æ°Žæº¶æ¶²äžã«ãã¢ã«æ°ãçããç¡é žé
ãšèåãããªãŠã ã®æº¶æ¶²ããã³ã³ãããŒã«ããã
ããã²ã³åéæ²æŸ±æ³ã«åŸã70âã§28åéã«ããã€
ãŠåæã«æ··åããããšã«ãããèåéä¹³å€ãåŸ
ããæ²æŸ±ãçµäºãããšçŽåŸçŽ0.5ÎŒmã®ïŒé¢äœã®çµ
æ¶ãçæããããã®èåéç²åã«éïŒã¢ã«åœãã
ãªç¡«é žãããªãŠã 1.7mgããã³éïŒã¢ã«åœãå¡©å
éé žã«ãªãŠã 2.5mgãæ·»å ãã70âã§30åéå ç±
ããããšã«ããååŠå¢æãæœãããååŠå¢æãæœ
ããèåéç²åã¯ã第ïŒåç®ãšåãæ²æŸ±ç°å¢ã§æŽ
ã«28åéæ²æŸ±ãè¡ãªãããšã«ãããæŽã«æé·ãã
çŽåŸçŽ0.8ÎŒã®ïŒé¢äœã®çµæ¶ãšãªã€ãã次ã«ãã®ä¹³
å€ã«ãéïŒã¢ã«åœãããªç¡«é žãããªãŠã 1.4mgã
ãã³éïŒã¢ã«åœãå¡©åéé žã«ãªãŠã 2.1mgãæ·»å
ãã65âã§20åéå ç±ããããšã«ãã€ãŠç²åè¡šé¢
ã®ååŠå¢æãè¡ãªã€ããåŸãããä¹³å€ãä¹³å€â
ãšããã æ¯èŒäŸ ïŒ æ¯èŒäŸâïŒã«åŸã€ãŠãããã²ã³åéä¹³å€ã調補
ãããäœããã³ã¢ä¹³å€ãååŠå¢æããåŸãã·ãšã«
ãæ²æŸ±ããåã«ãéïŒã¢ã«åœãïŒmgã®CdCl2ãæ·»
å ãããã®åŸåã³æ¯èŒäŸâïŒã«åŸã€ãŠããã²ã³å
éä¹³å€ã調補ãããåŸãããä¹³å€ãä¹³å€âãšã
ãã æ¯èŒäŸ ïŒ å€æåããã²ã³åéããã³è©²ã³ã¢ã被èŠããã
ãã²ã³åéã·ãšã«ãããªãã³ã¢ïŒã·ãšã«ä¹³å€ãäž
èšã®ããã«èª¿è£œããããŒã©ãã³10ïœãå«ã溶液äž
ã«æž©åºŠ60âã«å¶åŸ¡ããªãããç¡é žéã®ïŒã¢ã«æ°Žæº¶
液175mlãšå¡©åã«ãªãŠã 2.1ã¢ã«æ°Žæº¶æ¶²175mlãå
æã«10åéã§æ·»å ãã10åéã®ç©ççæãè¡ãªã€
ãåŸãèåã«ãªãŠã ïŒã¢ã«æ°Žæº¶æ¶²200mlãæ·»å ãã
æŽã«10åéã®ç©ççæãè¡ãªã€ãã次ãã§æ°ŽæŽã
è¡ãªã€ãŠã氎溶æ§ãã©ã€ããé€å»ããåŸããŒã©ã
ã³10ïœãæ·»å ããæ°Žãå ããŠå šé500mlãšããã
ãã®ããã«ããŠåŸãããã³ã¢ä¹³å€500mlã60âã«
å¶åŸ¡ããæªæããªãããç¡é žéã®ïŒã¢ã«æ°Žæº¶æ¶²
100mlãšå¡©åã«ãªãŠã ã®2.1ã¢ã«æ°Žæº¶æ¶²100mlãå
æã«ïŒåéã§æ·»å ããããšã«ãã€ãŠå¡©åéã·ãšã«
ãæ²æŸ±ãããããã«10åéã®ç©ççæãè¡ãªã€ã
åŸæ°ŽæŽãããåŸãããä¹³å€ãä¹³å€âãšããã å®æœäŸ ïŒ ãŒã©ãã³10ïœãå«ã溶液äžã«æž©åºŠã60âã«å¶åŸ¡
ããªãããç¡é žéã®ïŒã¢ã«æ°Žæº¶æ¶²175mlãšå¡©åã«
ãªãŠã 2.1ã¢ã«æ°Žæº¶æ¶²175mlãåæã«10åéã§æ·»å
ãã10åéã®ç©ççæãè¡ãªã€ãåŸãèåã«ãªãŠ
ã ïŒã¢ã«æ°Žæº¶æ¶²200mlãæ·»å ããæŽã«10åéã®ç©
ççæãè¡ãªã€ãã次ãã§æ°ŽæŽãè¡ãªã€ãŠæ°Žæº¶æ§
ãã©ã€ããé€å»ããåŸãå šéã500mlãšãããã
ã®ããã«ããŠåŸãããã³ã¢ä¹³å€500mlã60âã«å¶
埡ããæªæããªãããéïŒã¢ã«åœãïŒmgã®ã«ãªãŠ
ã ãããµã¯ããã€ãªããŒããæ·»å ãããã®åŸç¡é ž
éã®ïŒã¢ã«æ°Žæº¶æ¶²100mlãšå¡©åã«ãªãŠã ã®2.1ã¢ã«
氎溶液100mlãåæã«ïŒåéã§æ·»å ããããšã«ã
ã€ãŠå¡©åéã·ãšã«ãæ²æŸ±ãããããã«10åéã®ç©
ççæãè¡ãªã€ãåŸæ°ŽæŽãããåŸãããä¹³å€ãä¹³
å€âãšããã å®æœäŸ ïŒ ä¹³å€âãšåæ§ã®æ¹æ³ã§èª¿è£œãè¡ãªã€ããäœ
ãããããµã¯ããã€ãªããŒããæ·»å ããåŸãïŒâ
ããããã·âïŒïŒïŒïŒ3aïŒïŒâããã©ã¶ã€ã³ã
ã³ãéïŒã¢ã«åœã50mgæ·»å ãã次ãã§ãèåéã·
ãšã«ãæ²æŸ±ãããããã«ãå¡©åã«ãªãŠã ã®æ°Žæº¶æ¶²
ã®ãããã«èåã«ãªãŠã ã®2.1ã¢ã«æ°Žæº¶æ¶²100mlã
æ·»å ãããåŸãããä¹³å€ããä¹³å€âãšããã å®æœäŸ ïŒ ä¹³å€âãšåæ§ã®æ¹æ³ã§èª¿è£œãè¡ãªã€ããäœ
ããé žæ§æ¡ä»¶äžã§æ²æŸ±ãè¡ãªããã«ãªãŠã ãããµ
ã¯ããã€ãªããŒãã®ãããã«ç¡é žéãéïŒã¢ã«åœ
ã100mgæ·»å ãããåŸãããä¹³å€ãä¹³å€âãšã
ãã å®æœäŸ ïŒ åèšæ¯èŒäŸïŒãïŒåã³å®æœäŸâïŒãïŒã§èª¿è£œã
ãä¹³å€âããä¹³å€âã«ãã«ããªå€ãšããŠãïŒ
âãïŒâïŒïŒâããªã«ãã«ããã©ãžãïŒããšãã«ã
âïŒâããšãããªå°¿çŽ ãæ·»å ããé©åœãªå»¶å±å€å
ã³ç¡¬èå€ãå ããåŸãå¡åžéé35mgïŒ100cm2ãšãª
ãããã«ã»ã«ããŒã¹ããªã¢ã»ããŒãæ¯æäœäžã«å¡
åžã也ç¥ããã ãããã®è©Šæãæå èšãçšããŠã»ã³ã·ãã¡ããª
ãŒçšå åŠãŠãšããžãéããŠé²å ãã次ã®åŠæ¹ã®çŸ
å液ã§çŸåãã次ãã§å®çãæ°ŽæŽã也ç¥ãããçŸ
åã¯ã24âïŒåéãåã³18âïŒåéè¡ãªã€ãã ããšããã³ 0.4ïœ äºç¡«é žãœãŒãïŒç¡æ°ŽïŒ 75 ïœ ãã€ããããã³ 10 çé žãœãŒãïŒïŒæ°Žå¡©ïŒ 40 èåã«ãªãŠã ïŒ ïœ ïŒâã¡ãã«ãã³ãŸããªã¢ãŸãŒã« 10 mg æ°Žãå ããŠ ïŒ ïŒæ°Žé žåãããªãŠã ã§PH12.5ã«èª¿è£œããïŒ åŸãããããžç»åã«ã€ããŠæ倧æ¿åºŠããã³æå°
æ¿åºŠã枬å®ããçµæãè¡šâïŒã«ç€ºãã
ã«é¢ããæŽã«è©³ããã¯ç»åé²å åŸãå šé¢é²å ãäž
ãããããŸãã¯ã«ããªå€ã®ååšäžã«è¡šé¢çŸååŠç
ããããšã«ããçŽæ¥ããžç»åã®åŸãããå éšæœå
åããã²ã³åéä¹³å€å±€ãæããåçææã«é¢ãã
ãã®ã§ããã ïŒåŸæ¥æè¡ïŒ åŸæ¥ç¥ãããŠããçŽæ¥ããžç»åãåŸãæ¹æ³ãšã
ãŠã¯ãäž»ãšããŠïŒã€ã®ã¿ã€ãã«åããããããã®
ïŒã€ã®ã¿ã€ãã¯ããããããã«ããªæ žãæããã
ãã²ã³åéä¹³å€ãçšãããœãŒã©ãªãŒãŒã·ãšã³ãã
ããã¯ããŒã·ãšã«å¹æçãå©çšããŠé²å éšã®ã«ã
ãªæ žãŸãã¯æœåãç Žå£ããããšã«ãã€ãŠãçŸååŸ
ããžç»åãåŸããã®ã§ãããä»ã®ïŒã€ã®ã¿ã€ã
ã¯ãäºãã«ãããããŠããªãå éšæœååããã²ã³
åéä¹³å€ãçšããç»åé²å åŸã«ããªåŠçïŒçŸåæ ž
çæåŠçïŒãæœãã次ãã§è¡šé¢çŸåãè¡ãªããã
ãŸãã¯ç»åé²å åŸã«ããªåŠçïŒçŸåæ žçæåŠçïŒ
ãæœããªããè¡šé¢çŸåãè¡ãªãããšã«ãããããž
ç»åãåŸãããšãã§ãããã®ã§ããã äžèšã®ã«ããªåŠçïŒçŸåæ žçæåŠçïŒã®æ¹æ³
ã¯ãå šé¢é²å ãäžããããšã§ãããããã«ããªå€
ãçšããŠååŠçã«è¡ãªã€ãŠããããããŸã匷åãª
çŸå液ãçšããŠããããããã«ç±åŠççã«ãã€ãŠ
ãããã ããžç»åã圢æããããã®åèšïŒã€ã®æ¹æ³ã®ã
ã¡ãåŸè ã®ã¿ã€ãã®æ¹æ³ã¯ãåè ã®ã¿ã€ãã®æ¹æ³
ã«æ¯èŒããŠãäžè¬çã«æ床ãé«ããé«æ床ãèŠæ±
ãããå¿çšã«é©ããŠããã ãã®æè¡åéã«ãããŠã¯ãçš®ã ã®æè¡ããããŸ
ã§ã«ç¥ãããŠãããäŸãã°ãç±³åœç¹èš±2592250å·ã
å2466957å·ãå2497875å·ãå2588982å·ãå
3761266å·ãå3761276å·ãå3796577å·ããã³è±
åœç¹èš±1151363å·çã«èšèŒãããŠããæ¹æ³ãç¥ã
ããŠããã ãããå ¬ç¥ã®æè¡ãçšããããšã«ãã€ãŠãããž
ç»åã圢æããåçæå ææãäœãããšã¯ã§ãã
ãããããã®åçæå ææãåçš®ã®åçåéã«å¿
çšãããããã«ã¯ããäžå±€ã®åçæ§èœã®æ¹åãå
ã³è£œé äžã®åé¡ç¹ã®è§£æ±ºãæãŸããŠããã äŸãã°ãç±³åœç¹èš±3761276å·åã³å3206313å·ã«
é瀺ãããŠããããã«ããã²ã³åéç²åã®å éšã«
ååŠå¢æãæœããŸãã¯ãå€äŸ¡éå±ã€ãªã³ãããŒã
ããã³ã¢ïŒã·ãšã«åä¹³å€ãçšããããšã«ãã€ãŠã
ãé«ãæ床ãåŸãããšãã§ãããããã®çš®ã®ä¹³å€
ã¯ç»åæ¿åºŠãäœãåãé²å éãé倧ã«ãªããšåã³
ãã¬åãçŸåºãããšããæ¬ ç¹ãæããŠããããŸã
ç±³åœç¹èš±3761276å·ã«ã¯ãäžèšã®ç»åæ¿åºŠãäœã
ãšããæ¬ ç¹ãæ¹è¯ããçºãããã²ã³åéç²åè¡šé¢
ã«ããçšåºŠã®ååŠçæåŠçãæœãããšãé瀺ãã
ãŠããããããã²ã³åéä¹³å€ã®é·æä¿åã«å¯Ÿãã
å®å®æ§ã極ããŠæªãããŸã補é å®å®æ§ãæªããäž
å©ã§ããããŸããç±³åœç¹èš±4395478å·ã¯ãé²å é
ãé倧ã«ãªããšçŸããããã¬åãæå¶ãããã
ã«ãã³ã¢ïŒã·ãšã«åä¹³å€ã®ã·ãšã«éšåã«å€äŸ¡éå±
ã€ãªã³ãå«æãããæè¡ãé瀺ãããŠããããã
ãããŸãããã²ã³åéä¹³å€ã®é·æä¿åã«å¯Ÿããå®
å®æ§ã極ããŠæªããå®çšäžäžéœåã§ããã äžæ¹ãç±³åœç¹èš±2592250å·ã«é瀺ãããŠããå€
æåããã²ã³åéä¹³å€ã¯ãçžå¯Ÿçã«æº¶è§£åºŠã®é«ã
ããã²ã³åéã溶解床ã®äœãããã²ã³åéã«å€æ
ããããšã«ããæ¯èŒç容æã«è£œé ããããšãã§ã
ãããããã«æ床ã®äžæãæäœæ¿åºŠïŒDminïŒã®
æžå°ãæé«æ¿åºŠïŒDmaxïŒã®å¢å€§çåçæ§èœã®æ¹
è¯ãæãŸããŠãããç¹éæ55â127549å·ã§ã¯ãäž
èšã®æ¬ ç¹ãæ¹è¯ããçºãå€æåããã²ã³åéã³ã¢
ã«ããã²ã³åéã·ãšã«ã被èŠããã³ã¢ïŒã·ãšã«æ§
é ãæããããã²ã³åéä¹³å€ãé瀺ãããŠãã
ããçŸå枩床ãäœäžãããšç»åæ¿åºŠã®äœäžã倧ã
ãå®çšäžäžå©ã§ããã çŸå枩床ã®å€åã«å¯Ÿããåçæ§èœã®å®å®æ§ãå
äžãããããã«ããªãµãŒãã»ãã€ã¹ã¯ããŒãžã€ãŒ
ïŒResearch DisclosureïŒNo.15162åã³è±åœç¹èš±
2107074å·ã§ã¯ãéåžçåã®ã«ããªå€ãšåžçåã®
ã«ããªå€ãšã䜵çšããããšãèšèŒãããŠãããã
å åã«ç®çãéããã«ã¯å°ã€ãŠããªãã åŸã€ãŠããã®æ¹åŒã«ããçŽæ¥ããžåçæå ææ
ãå®çšåããçºã«ã¯ãçŸå枩床ã«ããåçæ§èœã®
å€åã®å°ãªããã€ã補é å®å®æ§ãä¿åå®å®æ§ã«åª
ããå éšæœååããã²ã³åéä¹³å€ã®åºçŸãæãŸã
ãã ïŒçºæã®ç®çïŒ åŸã€ãŠæ¬çºæã®ç®çã¯ãçŸå枩床ã®å€åã«å¯Ÿã
ãŠåçæ§èœã®å€åãå°ããããã€ãä¿åå®å®æ§ã
補é å®å®æ§ãåªããçŽæ¥ããžããã²ã³åéåçä¹³
å€ãæäŸããããšã«ããã ãŸããæ¬çºæã®ä»ã®ç®çã¯ããã®ãããªããã²
ã³åéåçä¹³å€ãããªãå±€ãå°ãªããšãäžå±€æ
ããããå®å®ããåçæ§èœãæããããã²ã³åé
åçæå ææãæäŸããããšã«ããã ïŒçºæã®æ§æïŒ åèšæ¬çºæã®ç®çã¯ãå éšæœååããã²ã³åé
ç²åãå«æããããã²ã³åéä¹³å€å±€ãæããé転
çŸåãŸãã¯ç §å°çŸåã«ãã€ãŠããžåç»åãäžãã
ããã²ã³åéåçèŠçŽ ã«æŒãŠã該ããã²ã³åéç²
åãäºããã®è¡šé¢ã«è¡šé¢çŸåæ žãæãããå€æå
ããã²ã³åéç²åãã³ã¢ãšããã³ã¢ïŒã·ãšã«åç²
åã§ãããäžã€è©²ç²åå éšã«å€äŸ¡éå±ã€ãªã³ãå
èµããããšãç¹åŸŽãšããããã²ã³åéåçèŠçŽ ã«
ãã€ãŠéæãããã åèšæ¬çºæã«è¬ãé転çŸåãããã¯ç §å°çŸåãš
ã¯ã倫ã æè¬ãã¶ãå€çã®äœ¿çšã«ããååŠçäœçš
ãããã¯å šé¢å ç §å°çã«ããå ååŠçäœçšã«ãã€
ãŠãæ¢ã«äžããããç»åé²å ã«ãã€ãŠçæããŠã
ãçŸåæ žãšååããŠè©²ç»åé²å éãšéæ¯äŸçã«ç
ããè¡šé¢çŸåæ žã«ããçŸåãè¬ãã æ¬çºæã®å éšæœååããã²ã³åéä¹³å€ã«ããã
å€æåããã²ã³åéã³ã¢ãšã¯ãæ°Žäžã§ã®æº¶è§£åºŠã
èåéãããé«ãå°ãªããšãäžéšã®éå¡©ç²åãã
æãä¹³å€ã圢æããã次ãã§ãããä¹³å€ç²åã®å°
ãªããšãäžéšãèåéãªããæ²èåéã«å€æãã
ããšã«ããäœãããããã²ã³åéç²åã§ãããé
åžžã¯ç¡é žé氎溶液ãšå¡©åç©ã®æ°Žæº¶æ¶²ããŒã©ãã³ç
ã®ä¿è·ã³ãã€ãã®ååšäžã«æ··åããçæããå¡©å
éä¹³å€ã«ãèåç©ã®æ°Žæº¶æ¶²ãæ·»å ããããšã«ãã
容æã«èª¿è£œããããæ¬çºæã«ãããå€æåããã²
ã³åéã³ã¢ç²åã¯å°ãªããšã80ã¢ã«ïŒ ã®èåéã
å«æããŠããããšã奜ãŸããããã€10ã¢ã«ïŒ 以äž
ã®æ²åéãå«æããŠããŠããããç¹ã«å°ãªããšã
90ã¢ã«ïŒ ã®èåéãšïŒã¢ã«ïŒ 以äžïŒïŒã¢ã«ïŒ ãã
å«ãïŒã®æ²åéãå«æããæ®ãã®ããã²ã³åç©ã
å¡©åéã§ããå€æåããã²ã³åéã³ã¢ãæŽã«å¥œãŸ
ããã æ¬çºæã®ã³ã¢ïŒã·ãšã«æ§é ã®ããã²ã³åéç²å
ã¯ãåèšã®å€æåããã²ã³åéã³ã¢ç²åã®è¡šé¢äž
ã«ããã²ã³åéãæ²æŸ±ãããŠããã²ã³åéã·ãšã«
ã圢æããããšã«ãã€ãŠäœãããæ§é ã®ç²åã§ã
ããã·ãšã«ã®ããã²ã³åéã¯å¡©åéãèåéãå¡©
èåéãæ²èåéããã³å¡©æ²èåéã®ããããã
æã€ãŠããŠãããããæ¬çºæã®å®æœæ æ§ã«ãããŠ
å¡©åéãªããã¯èåéã®åäžããã²ã³çµæã®ãã
ã²ã³åéã·ãšã«ãããªã€ãŠããããšã奜ãŸããã æŽã«ãã·ãšã«ã®åãã¯ã³ã¢ïŒã·ãšã«ãæ§æãã
ç·ããã²ã³åéãåºæºãšããŠã·ãšã«ã®ããã²ã³å
ééã30ã¢ã«ïŒ ãªãã50ã¢ã«ïŒ ã§ããã°å åã§ã
ããã·ãšã«ã®ããã²ã³åééã30ã¢ã«ïŒ æªæºã§ã
ããšé«æž©äžã§ã®ä¿åæ§ãæªãæå°æ¿åºŠãå¢å€§ãã
åŸåãçããäžæ¹50ã¢ã«ïŒ ãè¶ ãããšæ倧æ¿åºŠã
äœäžããã æ¬çºæã®å¥œãŸããå®æœæ æ§ã«ãããŠã¯ãããã²
ã³åéã·ãšã«ã圢æãããéã«ãããã©ã¶ã€ã³ã
ã³èªå°äœãå ±åãããããšã奜ãŸãããããã©ã¶
ã€ã³ãã³èªå°äœã¯ãäžè¬ã«ããã²ã³åéä¹³å€ã®å®
å®å€ãšããŠç¥ãããŠãããã®ãçšãããããç¹ã«
äžèšäžè¬åŒ(1)ã§è¡šãããããã®ã奜ãŸããã äžè¬åŒïŒïŒïŒ åŒäžãR1ããã³R2ã¯ããããæ°ŽçŽ ååã眮æ
åºãæããŠãããççŽ ååæ°ïŒããïŒåã®ã¢ã«ã
ã«åºã眮æåºãæããŠãããã¢ãªãŒã«åºãè¡šã
ãããŸãäºãã«çµåããŠïŒå¡ç°ãªããã¯ïŒå¡ç°ã
圢æããŠããããR3ã¯æ°ŽçŽ ååã眮æåºãæã
ãŠãããççŽ ååæ°ïŒããïŒåã®ã¢ã«ãã«åºãŸã
ã¯çœ®æåºãæããŠãããã¢ãªãŒã«åºãè¡šããã å ·äœçã«ã¯æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã®è¡š
é¢æ床ãã§ããã ãäœãæããããäœãæå°æ¿
床ãããå®å®ãªç¹æ§ãéäžããããããã«ãåèš
äžè¬åŒ(1)ã§è¡šããããå®å®å€ãäŸãã°ã¢ã¶ã€ã³ã
ã³ç°ãæã€ååç©ããã³ã¡ã«ã«ãããæããè€çŽ
ç°åŒååç©ïŒä»£è¡šçãªãã®ãšããŠããããïŒâã
ãããã·âïŒâã¡ãã«âïŒïŒïŒïŒ3aïŒïŒâãã
ã©ã¶ã€ã³ãã³ããã³ïŒâããšãã«âïŒâã¡ã«ã«ã
ãããã©ãŸãŒã«ãæããããŠãããïŒãå«æãã
ãããšãã§ããã ãã®ä»æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã«ã¯ãã
ã¶ãé²æ¢å€ãŸãã¯å®å®å€ãšããŠãäŸãã°æ°Žéåå
ç©ãããªã¢ãŸãŒã«ç³»ååç©ãã¢ã¶ã€ã³ãã³ç³»åå
ç©ããã³ãŸãã¢ãŸãªãŠã ç³»ååç©ãäºéååç©ç
ã䜿çšãåŸãã æ¬çºæã«ãããå éšæœååããã²ã³åéç²å
ã¯ãå€äŸ¡éå±ã€ãªã³ãç²åå éšã«åžèµããŠããã
ãã®ãããªããã²ã³åéä¹³å€ã¯ãããã²ã³åéç²
åã®åœ¢æåã«ãéå±ã€ãªã³ãåå¿å®¹åšäžã«å°å ¥ã
ããããããã¯ããã²ã³åéç²åã®æé·äžãåã¯
çé·ãäžæããŠããæã§æé·çµäºãã以åã®ãã
ããã®æ®µéã«ãããŠãåå¿å®¹åšäžã«å°å ¥ããããš
ã«ãã€ãŠåŸãããšãã§ãããå ·äœçã«è¿°ã¹ããªã
ã°ãå€äŸ¡éå±ã€ãªã³ã¯ãããã²ã³åéç²åã®åœ¢æ
åã«ãåã¯ãå€æãããã¹ãããã²ã³åéç²åã®
圢æäžãããã¯åœ¢æåŸã«ãåã¯å€æã®çºã®æ°Žæº¶æ§
ããã²ã³åç©ã®æ·»å äžã«ããŸãã¯å€æåŸãããã²
ã³åéã·ãšã«ã®åœ¢åŒãçµäºãã以åã«åå¿å®¹åšäž
ã«æ·»å ããããšãã§ããããæ¬çºæã®å®æœæ æ§ã«
ãããŠã¯ãããã²ã³åéã·ãšã«ã®2/3ãã圢æã
çµäºãã以åã«æ·»å ãããã®ã奜ãŸããã æ¬çºæã«ãããå€äŸ¡éå±ã€ãªã³ã®ïŒã€ã®å¥œãŸã
ãå ·äœäŸãšããŠã¯ãã€ãªãžãŠã ã€ãªã³ããããé
ïŒã¢ã«ã«å¯Ÿãã10-9ã10-3ã¢ã«ã®æ¿åºŠã§äœ¿çšãã
ã®ã奜ãŸãããããã«å¥œãŸããã¯ã10-8ã10-5ã¢
ã«ã®æ¿åºŠã§äœ¿çšãããã€ãªãžãŠã ã¯æ°Žæº¶æ§å¡©ãšã
ãŠãäŸãã°ã«ãªãŠã ãããµã¯ããã€ãªããŒããã
ããã¯ãããµããã¢ã€ãªããŒããšããŠæ·»å ããã
ããã²ã³åéç²åå ã«çµã¿èŸŒãŸããã æ¬çºæã«ãããå€äŸ¡éå±ã€ãªã³ã®ä»ã®ïŒã€ã®å¥œ
ãŸããå ·äœäŸãšããŠã¯éã€ãªã³ããããéã€ãªã³
ã¯ã氎溶æ§å¡©ãäŸãã°é ¢é žéãç¡é žéçã®åœ¢æ ã§
奜ãŸããã¯ãAg1ã¢ã«ã«å¯Ÿãã10-6ã10-2ã®æ¿åºŠ
ã§æ·»å ãããããã²ã³åéç²åå éšã«çµèŸŒãŸã
ãã æ¬çºæã«ãããå€äŸ¡éå±ã€ãªã³ã®ããã«å¥ã®å¥œ
ãŸããå ·äœäŸãšããŠã¯ãã¢ã³ãã¢ã³ã€ãªã³ããã¹
ãã¹ã€ãªã³ãéã€ãªã³ãçœéã€ãªã³ããªã¹ããŠã
ã€ãªã³ãããžãŠã ã€ãªã³çãããããããã®å€äŸ¡
éå±ã€ãªã³ã¯ã奜ãŸããã¯éïŒã¢ã«ã«å¯Ÿã10-9ã
10-4ã¢ã«ã®æ¿åºŠã§äœ¿çšãããã æ¬çºæã®å éšæœååããã²ã³åéç²åã¯ãç²å
è¡šé¢ãååŠçã«å¢æãããŠããªããããããã¯å¢
æãããŠããŠãå ããªçšåºŠã§ããããšã奜ãŸã
ãã ç²åè¡šé¢ãäºããã®è¡šé¢ã®è¡šé¢çŸåæ žãæããª
ããšããæå³ã¯ãæ¬çºæã«äœ¿çšãããä¹³å€ãéæ
ãªãã€ã«ã æ¯æäœäžã«35mgAgïŒcm2ã«ãªãããã«
å¡åžããè©Šéšçãé²å ããã«äžèšè¡šé¢çŸå液ã§
20âã§10åéçŸåããå Žåã«åŸãããæ¿åºŠã0.6
奜ãŸããã¯0.4ãè¶ããªãããšãããã è¡šé¢çŸå液 ã¡ããŒã« 2.5ïœ ïœâã¢ã¹ã³ã«ãã³é ž 10 ïœ NaBO2ã»4H2 35 ïœ KBr ïŒ ïœ æ°Žãå ããŠ ïŒ ãŸããæ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã¯ãäžèš
ã®ããã«ããŠäœæããè©Šéšçãé²å åŸãäžèšåŠæ¹
ã®å éšçŸå液ã§çŸåããå Žåã«ååãªæ¿åºŠãäž
ãããã®ã§ããã å éšçŸå液 ã¡ããŒã« ïŒ ïœ äºç¡«é žãœãŒãïŒç¡æ°ŽïŒ 90 ïœ ãã€ããããã³ ïŒ ïœ çé žãœãŒãïŒäžæ°Žå¡©ïŒ 52.5 ïœ KBr ïŒ ïœ KI 0.5 ïœ æ°Žãå ããŠ ïŒ æŽã«å ·äœçã«è¿°ã¹ããªãã°ãåèšè©²è©Šéšçã®äž
éšãçŽïŒç§ãŸã§ã®ããå®ããããæéã«ããã€ãŠ
å 匷床ã¹ã±ãŒã«ã«é²å ããå éšçŸå液ã§20âã§
ïŒåéçŸåããå Žåã«ãåäžæ¡ä»¶ã§é²å ãã該詊
éšçã®å¥ã®äžéšãè¡šé¢çŸå液ã§20âã§ïŒåéçŸ
åããå Žåã«åŸããããã®ãããå°ãªããšãïŒ
åã奜ãŸããã¯å°ãªããšã10åã®æ倧æ¿åºŠã瀺ã
ãã®ã§ããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã¯éåžžçšããã
ãå¢æè²çŽ ã«ãã€ãŠå åŠçã«å¢æããããšãã§ã
ããå éšæœååããã²ã³åéä¹³å€ããã¬åããã²
ã³åéä¹³å€çã®è¶ è²å¢æã«çšããããå¢æè²çŽ ã®
çµåãã¯æ¬çºæã®ããã²ã³åéä¹³å€ã«å¯ŸããŠãæ
çšã§ãããå¢æè²çŽ ã«ã€ããŠã¯ãªãµãŒãã»ãã€ã¹
ã¯ããŒãžã€ãŒïŒReseach DisclosureïŒNo.15162ã
åç §ããããšãã§ããã æ¬çºæã®åçæå èŠçŽ ãæããåçæå ææ
ïŒä»¥åŸåçææãšç§°ããïŒã¯æ®éã®æ¹æ³ã§æ®åœ±ã
ãåŸã«ãè¡šé¢çŸåããããšã«ãã€ãŠå®¹æã«çŽæ¥ã
ãžç»åãåŸãããšãã§ãããå³ã¡çŽæ¥ããžç»åã
äœæããäž»èŠãªå·¥çšã¯ãæ¬çºæã®è¡šé¢çŸåæ žãæ
ããªãå éšæœååããã²ã³åéä¹³å€å±€ãæããå
çææããç»åé²å åŸååŠçäœçšãããã¯å ååŠ
çäœçšã«ãã€ãŠè¡šé¢çŸåæ žãçæããåŠçïŒä»¥åŸ
ã«ããªåŠçãšç§°ãïŒãæœããåŸã§ããã³ïŒãŸãã¯
ã«ããªåŠçãæœããªããè¡šé¢çŸåãè¡ãªãããšã
ããªããããã§ã«ããªåŠçã¯ãå šé¢é²å ãäžãã
ããããã¯è¡šé¢çŸåæ žãçæããååç©ïŒä»¥åŸã«
ããªå€ãšç§°ãïŒãçšããŠè¡ãªãããšãã§ããã æ¬çºæã«æŒããŠãå šé¢é²å ã¯ç»åé²å ããæå
ææãçŸå液ãããã¯ãã®ä»ã®æ°Žæº¶æ¶²ã«æµžæŒ¬ãã
ããŸãã¯æ¹¿æœ€ãããåŸãå šé¢çã«åäžé²å ããã
ãšã«ãã€ãŠè¡ãªããããããã§äœ¿çšããå æºãšã
ãŠã¯åçææã®æå æ³¢é·åå ã®å ã§ããã°ããã
ã§ããããåãã©ãã·ãŠå ã®ããšãé«ç §åºŠå ãç
æéããŠãããšãã§ãããããŸãã¯åŒ±ãå ãé·æ
éããŠããããããŸãå šé¢é²å ã®æéã¯åçæ
æãçŸååŠçæ¡ä»¶ã䜿çšããå æºã®çš®é¡çã«ã
ããæçµçã«æè¯ã®ããžç»åãåŸãããããåºç¯
å²ã«å€ããããšãã§ããã è¯å¥œãªããžç»ãåŸããããããªå šé¢é²å ã®ç §åºŠ
ããã³é²å æéã®ç¯å²ãéžè±ããæ¡ä»¶ã§å šé¢é²å
ãè¡ãªããšãåŸãããããžç»åã®ç»è³ªã¯å£åã
ããäŸãã°é床ã«é«ãç §åºŠã®å šé¢é²å ãè¡ãªã
ãšãç»åã®æé«æ¿åºŠã¯äœäžããæäœæ¿åºŠã¯äžæã
ããåé床ã«äœãç §åºŠã®å šé¢é²å ãè¡ãªããšæé«
æ¿åºŠã®äœãç»åããåŸãããªããè¯å¥œãªç»åãäž
ããããšã®ã§ããå šé¢é²å ã®èš±å®¹å¹ ã¯ãæ¬çºæã®
ããã²ã³åéä¹³å€ã䜿çšããããšã«ãã€ãŠæ¡å€§ã
ããã€ãŸããæ¬çºæã®ããã²ã³åéä¹³å€ã䜿çšã
ãã°ããé«ãç §åºŠã§ãæå°æ¿åºŠãäžæããããã
äœãç §åºŠã§ãååãªæé«æ¿åºŠãåŸãããã æ¬çºæã«ãããŠäœ¿çšããã«ããªå€ãšããŠã¯åºç¯
å²ãªçš®é¡ã®ååç©ãçšããããšãã§ãããã®ã«ã
ãªå€ã¯çŸååŠçæã«ååšããã°ãããäŸãã°ãå
çææã®æ¯æäœä»¥å€ã®æ§æå±€äžïŒãã®äžã§ãç¹ã«
ããã²ã³åéä¹³å€å±€äžã奜ãŸããïŒããããã¯çŸ
å液ãããã¯çŸååŠçã«å ç«ã€åŠç液ã«å«æãã
ããŠãããããŸããã®äœ¿çšéã¯ç®çã«å¿ããŠåºç¯
å²ã«å€ããããšãã§ãã奜ãŸããæ·»å éãšããŠ
ã¯ãããã²ã³åéä¹³å€å±€äžã«æ·»å ãããšãã¯ãã
ãã²ã³åéïŒã¢ã«åœãïŒã1500mgã奜ãŸããã¯10
ã1000mgã§ããããŸããçŸå液çã®åŠç液ã«æ·»å
ãããšãã®å¥œãŸããæ·»å éã¯0.01ãïŒïœïŒãç¹
ã«å¥œãŸããã¯0.05ãïŒïœïŒã§ããã æ¬çºæã«çšããã«ããªå€ãšããŠã¯ãäŸãã°ç±³åœ
ç¹èš±2563785å·ãå2588982å·ã«èšèŒãããŠããã
ãã©ãžã³é¡ããããã¯ç±³åœç¹èš±3227552å·ã«èšèŒ
ãããããã©ãžããŸãã¯ããã©ãŸã³ååç©ïŒç±³åœ
ç¹èš±3615615å·ãå3718470å·ãå3719494å·ãå
3734738å·ããã³å3759901å·ã«èšèŒãããè€çŽ ç°
第ïŒçŽçªçŽ å¡©åååç©ïŒæŽã«ç±³åœç¹èš±4030925å·
èšèŒã®ã¢ã·ã«ããã©ãžãããšãã«ããªå°¿çŽ é¡ã®åŠ
ããããã²ã³åéè¡šé¢ãžã®åžçåºãæããååç©
ãæããããããŸãããããã®ã«ããªå€ã¯çµåã
ãŠçšããããšãã§ãããäŸãã°ãªãµãŒãã»ãã€ã¹
ã¯ããŒãžã€ãŒïŒReseach DisclosureïŒNo.15162ã«
ã¯éåžçåã®ã«ããªå€ãåžçåã®ã«ããªå€ãšäœµçš
ããããšãèšèŒãããŠããã æ¬çºæã«çšããã«ããªå€ãšããŠã¯ãåžçåãé
åžçåã®ãã¥ãã䜿çšããããšãã§ãããããã
ãã䜵çšããŠäœ¿çšããããšãã§ããããæ¬çºæã®
ïŒã€ã®å¥œãŸããå®æœæ æ§ã«ãããŠã¯ãå°ãªããšã
äžçš®ã®åžçåã®ã«ããªå€ã䜿çšãããã éåžžãçŸåæã«ã«ããªå€ãéå°ã«ååšãããšã
æ床ã®äœäžãæäœæ¿åºŠã®äžæãåŒããããå Žåã
ããããæ¬çºæã®ä¹³å€ãçšããå Žåãã«ããªå€é
ã«å¯Ÿãã蚱容床ã¯åºããã æçšãªã«ããªå€ã®å ·äœäŸã瀺ãã°ãããã©ãžã³
å¡©é žå¡©ãããšãã«ããã©ãžã³å¡©é žå¡©ãïŒâã¡ãã«
ããšãã«ããã©ãžã³å¡©é žå¡©ãïŒâãã«ãã«âïŒâ
ïŒïŒâã¡ãã«ããšãã«ïŒããã©ãžã³ãïŒâã¢ã»ã
ã«âïŒâããšãã«ããã©ãžã³ãïŒâã¢ã»ãã«âïŒ
âïŒïŒâã¢ã»ãã¢ããããšãã«ïŒããã©ãžã³ãïŒ
âã¡ãã«ã¹ã«ããªãã«âïŒâããšãã«ããã©ãž
ã³ãïŒâãã³ãŸã€ã«âïŒâããšãã«ããã©ãžã³ã
ïŒâã¡ãã«ã¹ã«ããªãã«âïŒâïŒïŒâããšãã«ã¹
ã«ããªã³ã¢ããããšãã«ïŒããã©ãžã³ãããªã«ã
ã¢ã«ãããããšãã«ããã©ãžã³çã®ããã©ãžã³å
åç©ïŒïŒâïŒïŒâãã«ãã«ãšãã«ïŒâïŒâã¡ãã«ã
ã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒâïŒïŒâãã«ã
ã«ãšãã«ïŒâïŒâãããã«ãã³ãŸãã¢ãŸãªãŠã ã
ããã€ããïŒâïŒïŒâã¢ã»ãã«ãšãã«ïŒâïŒâãã³
ãžã«ãã³ãŸã»ã¬ããŸãªãŠã ãããã€ããïŒâïŒïŒ
âã¢ã»ãã«ãšãã«âïŒâãã³ãžã«âïŒâããšãã«
âãã³ãŸãªããµãŸãªãŠã ãããã€ããïŒâã¡ãã«
âïŒâãïŒâïŒããšãã«ããã©ãŸãïŒãããã«ãã
ã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒâã¡ãã«âïŒâ
ãïŒâïŒïœâããªã«ããã©ãŸãïŒãããã«ããã³ãŸ
ãã¢ãŸãªãŠã ãããã€ããïŒâã¡ãã«âïŒâãïŒ
âïŒïœâã¹ã«ããªããšãã«ããã©ãŸãïŒãããã«ã
ãã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒâã¡ãã«âïŒ
âãïŒâïŒïœâã¹ã«ããªããšãã«ããã©ãŸãïŒãã³
ãã«ããã³ãŸãã¢ãŸãªãŠã ãšãŒãããïŒïŒïŒâãž
ãããâïŒâã¡ãã«âïŒâããšãã«ããªããïŒïŒ
ïŒâïœããã³ãŸãã¢ãŸãªãŠã ãããã€ããïŒïŒïŒ
âãžãããâïŒâã¡ãã«âïŒâããšãã«ããªã
ãïŒïŒïŒâïœãâïŒâããšãã«ãã³ãŸãªããµãŸãªãŠ
ã ãããã€ããïŒïŒïŒâãšãã¬ã³ãã¹ïŒïŒïŒïŒâ
ãžãããâïŒâã¡ãã«ããªããïŒïŒïŒâïœããã³
ãŸãã¢ãŸãªãŠã ãããã€ãïŒãïŒïŒïŒâãžããã
âïŒâã¡ãã«âïŒâããšãã«ããªããïŒïŒïŒâ
ïœããã³ãŸã»ã¬ããŸãªãŠã ãããã€ãçã®ïŒ®â眮
æ第ïŒçŽã·ã¯ãã¢ã³ã¢ããŠã å¡©ïŒïŒâãïŒâãšã
ã«ãããïŒïŒïŒïŒâïœïŒãã¢ãŸãªã³âïŒâã€ãªã
ã³ãšããªãã³ãâïŒâïŒïŒâããšãã«ã«ã«ããŸã€
ã«ïŒã¡ãã«âïŒâïŒïŒâã¹ã«ãã¢ã¢ã€ã«ããšãã«ïŒ
âïŒâããªããã³ãã€ã³ãïŒâïŒïŒâãšãã«âïŒ
âãã³ãŸãã¢ãŸãªããªãã³ïŒâïŒâãïŒâïŒïŒâã
ãªã«ãã«ããã©ãžãïŒããšãã«ãããŒããã³ãïŒ
âãïŒâïŒïŒâããªã«ãã«ããã©ãžãïŒããšãã«ã
ïŒâããšãã«ããªå°¿çŽ ãïŒïŒïŒâãã¹ãïŒâïŒïŒ
âããªã«ãã«ããã©ãžãïŒããšãã«ãããªå°¿çŽ ãª
ã©ãæããããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€å±€ãæããåç
ææã¯åæ§é²å åŸãå šé¢é²å ããããŸãã¯ã«ããª
å€ã®ååšäžã«çŸååŠçããããšã«ãã€ãŠçŽæ¥ããž
ç»åã圢æãããæ¬çºæã«ä¿ãåçææã®çŸååŠ
çæ¹æ³ã¯ä»»æã®çŸååŠçæ¹æ³ãæ¡çšããããã奜
ãŸããã¯è¡šé¢çŸååŠçæ¹æ³ã§ããããã®è¡šé¢çŸå
åŠçæ¹æ³ãšã¯ããã²ã³åé溶å€ãå®è³ªçã«å«ãŸãª
ãçŸå液ã§åŠçããããšãæå³ããã æ¬çºæã«ä¿ãåçææã®çŸåã«çšããçŸå液ã«
ãããŠäœ¿çšããããšã®ã§ããçŸåå€ãšããŠã¯ãé
åžžã®ããã²ã³åéçŸåå€ãäŸãã°ãã€ããããã³
ã®åŠãããªããããã·ãã³ãŒã³é¡ãã¢ããããšã
ãŒã«é¡ãïŒâãã©ãŸãªãã³é¡ãã¢ã¹ã³ã«ãã³é žãš
ãã®èªå°äœãã¬ãã¯ãã³é¡ãããšãã¬ã³ãžã¢ãã³
é¡çãããã¯ãã®æ··åç©ãå«ãŸãããå ·äœçã«ã¯
ãã€ããããã³ãã¢ããããšããŒã«ãâã¡ãã«
ã¢ããããšããŒã«ãïŒâããšãã«âïŒâãã©ãŸãª
ãã³ãïŒâããšãã«âïŒïŒïŒâãžã¡ãã«âïŒâã
ã©ãŸãªãã³ãïŒâããšãã«âïŒâã¡ãã«âïŒâã
ãããã·ã¡ãã«âïŒâãã©ãŸãªãã³ãã¢ã¹ã³ã«ã
ã³é žãïŒïŒ®âãžãšãã«âïœâããšãã¬ã³ãžã¢ã
ã³ããžãšãã«ã¢ããâïœâãã«ã€ãžã³ãïŒâã¢ã
ãâïŒâã¡ãã«ââãšãã«ââïŒÎ²âã¡ã¿ã³
ã¹ã«ããªã³ã¢ãããšãã«ïŒã¢ããªã³ãïŒâã¢ãã
âïŒâã¡ãã«ââãšãã«ââïŒÎ²âãããã
ã·ãšãã«ïŒã¢ããªã³çãæããããããããã®çŸ
åå€ã¯ãããããä¹³å€äžã«å«ãŸããŠãããé«PHæ°Ž
溶液浞挬äžã«ããã²ã³åéã«äœçšãããããã«ã
ãããšãã§ããã æ¬çºæã«ãããŠäœ¿çšãããçŸå液ã¯ãæŽã«ç¹å®
ã®ãã¶ãé²æ¢å€åã³çŸåæå¶å€ãå«æããããšã
ã§ãããããã¯ãããã®çŸå液添å å€ãåçææ
ã®æ§æå±€äžã«ä»»æã«çµã¿å ¥ããããšãå¯èœã§ã
ããéåžžæçšãªãã¶ãé²æ¢å€ã«ã¯ããã³ãŸããªã¢
ãŸãŒã«é¡äŸãã°ïŒâã¡ãã«ãã³ãŸããªã¢ãŸãŒã«ã
ãã³ãã€ãããŸãŒã«é¡ããã³ãŸãã¢ãŸãŒã«é¡ãã
ã³ãŸãªããµãŸãŒã«é¡ãïŒâããšãã«âïŒâã¡ã«ã«
ããããã©ãŸãŒã«ã®ãããªè€çŽ ç°åŒããªã³é¡ãè³
éŠæåã³èèªæã®ã¡ã«ã«ããååç©çãå«ãŸã
ãããŸããçŸå液äžã«ã¯çŸåä¿é²å€äŸãã°ããªã¢
ã«ãã¬ã³ãªããµã€ãèªå°äœã第ïŒçŽã¢ã³ã¢ããŠã
å¡©ååç©ãªã©ãå«æãããããšãã§ããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã«ã¯ãåçš®ã®å
ççšæ·»å å€ãå ããããšã¯ä»»æã§ããã ãã®ä»æ¬çºæã«ãããŠãç®çã«å¿ããŠçšããã
ãæ·»å å€ã¯ã湿最å€ãšããŠã¯ãäŸãã°ããžããã
ãã·ã¢ã«ã«ã³çãæããããããã«èç©æ§æ¹è¯å€
ãšããŠã¯ãäŸãã°ãã¢ã«ãã«ã¢ã¯ãªã¬ãŒãããã
ã¯ã¢ã«ãã«ã¡ã¿ã¢ã¯ãªã¬ãŒããšã¢ã¯ãªã«é žããã
ã¯ã¡ã¿ã¢ã¯ãªã«é žãšã®å ±éåäœãã¹ãã¬ã³âãã¬
ã€ã³é žå ±éåäœãã¹ãã¬ã³ç¡æ°Žãã¬ã€ã³é žããŒã
ã¢ã«ãã«ãšã¹ãã«å ±éåäœçã®ä¹³åéåã«ãã€ãŠ
åŸãããæ°Žåæ£æ§ã®åŸ®ç²åç¶é«ååç©è³ªçãé©åœ
ã§ãããå¡åžå©å€ãšããŠã¯ãäŸãã°ããµããã³ã
ããªãšãã¬ã³ã°ãªã³ãŒã«ã©ãŠãªã«ãšãŒãã«çãå«
ãŸããããã®ä»åççšæ·»å å€ãšããŠããŒã©ãã³å¯
å¡å€ãçé¢æŽ»æ§å€ã玫å€ç·åžåå€ãPH調æŽå€ãé ž
åé²æ¢å€ã垯é»é²æ¢å€ãå¢ç²å€ãç²ç¶æ§åäžå€ã
ææãã¢ã«ãã³ããå¢çœå€ãçŸåé床調ç¯å€ãã
ããå€çã䜿çšããããšã¯ä»»æã§ããã äžè¿°ã®åŠã調æŽãããããã²ã³åéä¹³å€ã¯ãå¿
èŠã«å¿ããŠäžåŒå±€ããã¬ãŒã·ãšã³é²æ¢å±€ããã€ã«
ã¿ãŒå±€çãä»ããŠæ¯æäœã«å¡åžããå éšæœååã
ãã²ã³åéåçææãåŸãã æ¬çºæã«ä¿ãåçææãã«ã©ãŒçšã«é©çšããã
ãšã¯æçšã§ããããã®å Žåããã²ã³åéåçä¹³å€
äžã«ã·ã¢ã³ãããŒã³ã¿ããã³ã€ãšããŒã®è²çŽ å圢
æã«ãã©ãŒãå«ãŸããããšã奜ãŸãããã«ãã©ãŒ
ãšããŠã¯éåžžçšãããããã®ã䜿çšã§ããã ãŸããè²çŽ ç»åã®çæ³¢é·ã®æŽ»æ§å ç·ã«ããè€è²
ãé²æ¢ãããã玫å€ç·åžåå€ãäŸãã°ãã¢ãŸãªã
ã³ããã³ãŸããªã¢ãŸãŒã«ãã¢ã¯ãªããããªã«ãã
ã³ãŸããšãã³ç³»ååç©ãçšããããšã¯æçšã§ã
ããç¹ã«ãããã³PSãå320ãå326ãå327ãå
328ïŒããããããã¬ã€ã®ãŒç€Ÿè£œïŒã®åçšãããã¯
䜵çšãæå©ã§ããã æ¬çºæã«ä¿ãåçæå ææã®æ¯æäœãšããŠã¯ä»»
æã®ãã®ãçšãããããã代衚çãªæ¯æäœãšããŠ
ã¯ãå¿ èŠã«å¿ããŠäžåŒå å·¥ããããªãšãã¬ã³ãã¬
ãã¿ã¬ãŒããã€ã«ã ãããªã«ãŒãããŒããã€ã«
ã ãããªã¹ãã¬ã³ãã€ã«ã ãããªãããã¬ã³ãã€
ã«ã ãã»ã«ããŒãºã¢ã»ããŒããã€ã«ã ãã¬ã©ã¹ã
ãã©ã€ã¿çŽãããªãšãã¬ã³ã©ãããŒãçŽçãå«ãŸ
ããã æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ã«ã¯ä¿è·ã³ãã€
ããããã¯çµåå€ãšããŠãŒã©ãã³ã®ä»ã«ç®çã«å¿
ããŠé©åœãªãŒã©ãã³èªå°äœãçšããããšãã§ã
ãããã®é©åœãªãŒã©ãã³èªå°äœãšããŠã¯ãäŸã
ã°ãã¢ã·ã«åãŒã©ãã³ãã°ã¢ããžã«åãŒã©ãã³ã
ã«ã«ããã«åãŒã©ãã³ãã·ã¢ããšã¿ããŒã«åãŒã©
ãã³ããšã¹ãã«åãŒã©ãã³çãæããããšãã§ã
ãã ãŸããæ¬çºæã«ãããŠã¯ãç®çã«å¿ããŠä»ã®èŠª
æ°Žæ§çµåå€ãå«ãŸããããšãã§ãããã®é©åœãªçµ
åå€ãšããŠã¯ãŒã©ãã³ã®ã»ããã³ãã€ãç¶ã¢ã«ã
ãã³ãå¯å€©ãã¢ã©ãã¢ãŽã ãããã¹ãã©ã³ãã¢ã«
ã®ã³é žãã¢ã»ãã«å«æ19ã20ïŒ ã«ãŸã§å æ°Žå解ã
ããã»ã«ããŒãºã¢ã»ããŒãã®åŠãã»ã«ããŒãºèªå°
äœãããªã¢ã¯ãªã«ã¢ãããã€ããåããªã¢ã¯ãªã«
ã¢ãããã«ãŒã€ã³ãããã«ã¢ã«ã³ãŒã«âããã«ã¢
ããã¢ã»ããŒãã³ããªããŒã®åŠããŠã¬ã¿ã³ã«ã«ã
ã³é žåºãŸãã¯ãã·ã¢ãã¢ã»ãã«åºãå«ãããã«ã¢
ã«ã³ãŒã«ããªããŒãããªããã«ã¢ã«ã³ãŒã«ãããª
ããã«ãããªãã³ãå æ°Žå解ããªããã«ã¢ã»ããŒ
ããèçœè³ªãŸãã¯é£œåã¢ã·ã«åèçœè³ªãšããã«åº
ãæããã¢ãããŒãšã®éåã§åŸãããããªããŒã
ããªããã«ããªãžã³ãããªããã«ã¢ãã³ãããªã¢
ãããšãã«ã¡ã¿ã¢ã¯ãªã¬ãŒããããªãšãã¬ã³ã¢ã
ã³çãå«ãŸããä¹³å€å±€ãããã¯äžéå±€ãä¿è·å±€ã
ãã€ã«ã¿ãŒå±€ãè£åŒå±€çã®åçæææ§æå±€ã«ç®ç
ã«å¿ããŠæ·»å ããããšãã§ããããã«äžèšèŠªæ°Žæ§
ãã€ã³ããŒã«ã¯ç®çã«å¿ããŠé©åœãªå¯å¡å€ã最æ»
å€çãå«æããããããšãã§ããã ãŸããæ¬çºæã«ä¿ãåçææã®æ§æå±€ã¯ä»»æã®
é©åœãªç¡¬èå€ã§ç¡¬åããããããšãã§ããããã
ãã®ç¡¬èå€ãšããŠã¯ãã¯ãã å¡©ããžã«ã³ããŠã
é¡ãããªã«ã ã¢ã«ããããã ã³ããã²ã³é žã®åŠã
ã¢ã«ãããç³»ãããããªã¢ãžã³ç³»ãããªãšããã·
ååç©ããšãã¬ã³ã€ãã³ç³»ãããã«ã¹ã«ããªã³
ç³»ãã¢ã¯ãªãã€ã«ç³»ç¡¬èå€çãæããããã ãŸããæ¬çºæã«ä¿ãåçææã¯ãæ¯æäœäžã«ä¹³
å€å±€ããã€ã«ã¿ãŒå±€ãäžéå±€ãä¿è·å±€ãäžåŒå±€ã
è£åŒå±€ããã¬ãŒã·ãšã³é²æ¢å±€çã®çš®ã ã®åçæ§æ
å±€ãå€æ°èšçœ®ããããšãå¯èœã§ããã æ¬çºæã«ä¿ãåçææã¯ãçœé»äžè¬çšãã¬ã€
çšãã«ã©ãŒçšãåœã«ã©ãŒçšãå°å·çšãèµ€å€çšãã
ã€ã¯ãçšãéè²çŽ æŒçœçšçã®çš®ã ã®çšéã«æå¹ã«
é©çšããããšãã§ãããŸããã³ãã€ã転åæ³ãé
å¡©æ¡æ£è»¢åæ³ãããžã€ãŒã¹ã®ç±³åœç¹èš±3087817å·ã
å3185567å·åã³å2983606å·ããŠãšã€ã€ãŒããã®
ç±³åœç¹èš±3253915å·ããã¯ã€ãã¢ã¢ãã®ç±³åœç¹èš±
3227550å·ãããŒã«ãã®ç±³åœç¹èš±3227551å·ããã¯
ã€ãã¢ã¢ã®ç±³åœç¹èš±3227552å·ããã³ã©ã³ãã®ç±³
åœç¹èš±3415644å·ãå3415645å·ããã³å3415646
å·ã«èšèŒãããŠãããããªã«ã©ãŒç»å転åæ³ãã«
ã©ãŒæ¡æ£è»¢åæ³ãåžå転åæ³çã«ãé©çšã§ããã ïŒçºæã®å¹æïŒ æ¬çºæã«ä¿ãããã²ã³åéä¹³å€ãçšããããšã«
ãããçŸå枩床ãå€åããŠããåçæ§èœã®å€åã
å°ãªãå®å®ãªããã²ã³åéåçæå ææãåŸã
ãããã€ã該æå ææãé·æã«ããã€ãŠä¿åããŠ
ãããã®åçæ§èœãå®å®ããŠããããã²ã³åéå
çæå ææãã容æã«è£œé ããããšãã§ããããŸ
ããã®åªããæ§èœã¯ãå€æåã³ã¢ãšãããã被èŠ
ããããã²ã³åéã·ãšã«ãšã«ããã³ã¢ïŒã·ãšã«æ§
é ã®ç¹æ§åã³åžèµãããå€äŸ¡éå±ã€ãªã³ã®ç¹æ§
ããçžè£çã«äœçšããŠçŸåºããŠãããã®ãšèãã
ããã ïŒå®æœäŸïŒ 以äžãå®æœäŸããããŠæ¬çºæãäŸèšŒããããæ¬
çºæã®å®æœã®æ æ§ãããã«ãã€ãŠéå®ããããã®
ã§ã¯ãªãã æ¯èŒäŸ ïŒ ç¹éæ47â32813å·ã®å®æœäŸâïŒã«èšèŒãããŠ
ããæ¹æ³ã«åŸã€ãŠæ²èåéä¹³å€ïŒæ²åç©2.5ã¢ã«
ïŒ ïŒã調補ãããããªãã¡ãéïŒã¢ã«åœãïŒå¡©å
ã€ãªãžãŠã é žã«ãªãŠã 10.7mgãå«æããè¿ éã«æª
æããããŒã©ãã³æ°Žæº¶æ¶²ã«å¯ŸããŠãç¡é žé氎溶液
åã³èåã«ãªãŠã ãšæ²åã«ãªãŠã ã®æ°Žæº¶æ¶²ãåæ
ã«å ããããã®éãæ²æŸ±ã¯é žæ§åªäœäžã«ãããŠã
pAg8.9ã§ãã€ãŠ70â60åéã«ããã€ãŠè¡ãªã€ãã
ãã®åŸæ°ŽæŽãè¡ãªã€ãŠæ°Žæº¶æ§ãã©ã€ããé€å»ãã
åŸããŒã©ãã³ãå ããããã®åŸãããä¹³å€ãä¹³å€
âãšããã æ¯èŒäŸ ïŒ ç¹å ¬æ52â34213å·ã«èšèŒãããŠããå®æœäŸïŒ
ã«åŸã€ãŠããã²ã³åéä¹³å€ã調補ãããããªã
ã¡ããŒã©ãã³æ°Žæº¶æ¶²äžã«ãã¢ã«æ°ãçããç¡é žé
ãšèåãããªãŠã ã®æº¶æ¶²ããã³ã³ãããŒã«ããã
ããã²ã³åéæ²æŸ±æ³ã«åŸã70âã§28åéã«ããã€
ãŠåæã«æ··åããããšã«ãããèåéä¹³å€ãåŸ
ããæ²æŸ±ãçµäºãããšçŽåŸçŽ0.5ÎŒmã®ïŒé¢äœã®çµ
æ¶ãçæããããã®èåéç²åã«éïŒã¢ã«åœãã
ãªç¡«é žãããªãŠã 1.7mgããã³éïŒã¢ã«åœãå¡©å
éé žã«ãªãŠã 2.5mgãæ·»å ãã70âã§30åéå ç±
ããããšã«ããååŠå¢æãæœãããååŠå¢æãæœ
ããèåéç²åã¯ã第ïŒåç®ãšåãæ²æŸ±ç°å¢ã§æŽ
ã«28åéæ²æŸ±ãè¡ãªãããšã«ãããæŽã«æé·ãã
çŽåŸçŽ0.8ÎŒã®ïŒé¢äœã®çµæ¶ãšãªã€ãã次ã«ãã®ä¹³
å€ã«ãéïŒã¢ã«åœãããªç¡«é žãããªãŠã 1.4mgã
ãã³éïŒã¢ã«åœãå¡©åéé žã«ãªãŠã 2.1mgãæ·»å
ãã65âã§20åéå ç±ããããšã«ãã€ãŠç²åè¡šé¢
ã®ååŠå¢æãè¡ãªã€ããåŸãããä¹³å€ãä¹³å€â
ãšããã æ¯èŒäŸ ïŒ æ¯èŒäŸâïŒã«åŸã€ãŠãããã²ã³åéä¹³å€ã調補
ãããäœããã³ã¢ä¹³å€ãååŠå¢æããåŸãã·ãšã«
ãæ²æŸ±ããåã«ãéïŒã¢ã«åœãïŒmgã®CdCl2ãæ·»
å ãããã®åŸåã³æ¯èŒäŸâïŒã«åŸã€ãŠããã²ã³å
éä¹³å€ã調補ãããåŸãããä¹³å€ãä¹³å€âãšã
ãã æ¯èŒäŸ ïŒ å€æåããã²ã³åéããã³è©²ã³ã¢ã被èŠããã
ãã²ã³åéã·ãšã«ãããªãã³ã¢ïŒã·ãšã«ä¹³å€ãäž
èšã®ããã«èª¿è£œããããŒã©ãã³10ïœãå«ã溶液äž
ã«æž©åºŠ60âã«å¶åŸ¡ããªãããç¡é žéã®ïŒã¢ã«æ°Žæº¶
液175mlãšå¡©åã«ãªãŠã 2.1ã¢ã«æ°Žæº¶æ¶²175mlãå
æã«10åéã§æ·»å ãã10åéã®ç©ççæãè¡ãªã€
ãåŸãèåã«ãªãŠã ïŒã¢ã«æ°Žæº¶æ¶²200mlãæ·»å ãã
æŽã«10åéã®ç©ççæãè¡ãªã€ãã次ãã§æ°ŽæŽã
è¡ãªã€ãŠã氎溶æ§ãã©ã€ããé€å»ããåŸããŒã©ã
ã³10ïœãæ·»å ããæ°Žãå ããŠå šé500mlãšããã
ãã®ããã«ããŠåŸãããã³ã¢ä¹³å€500mlã60âã«
å¶åŸ¡ããæªæããªãããç¡é žéã®ïŒã¢ã«æ°Žæº¶æ¶²
100mlãšå¡©åã«ãªãŠã ã®2.1ã¢ã«æ°Žæº¶æ¶²100mlãå
æã«ïŒåéã§æ·»å ããããšã«ãã€ãŠå¡©åéã·ãšã«
ãæ²æŸ±ãããããã«10åéã®ç©ççæãè¡ãªã€ã
åŸæ°ŽæŽãããåŸãããä¹³å€ãä¹³å€âãšããã å®æœäŸ ïŒ ãŒã©ãã³10ïœãå«ã溶液äžã«æž©åºŠã60âã«å¶åŸ¡
ããªãããç¡é žéã®ïŒã¢ã«æ°Žæº¶æ¶²175mlãšå¡©åã«
ãªãŠã 2.1ã¢ã«æ°Žæº¶æ¶²175mlãåæã«10åéã§æ·»å
ãã10åéã®ç©ççæãè¡ãªã€ãåŸãèåã«ãªãŠ
ã ïŒã¢ã«æ°Žæº¶æ¶²200mlãæ·»å ããæŽã«10åéã®ç©
ççæãè¡ãªã€ãã次ãã§æ°ŽæŽãè¡ãªã€ãŠæ°Žæº¶æ§
ãã©ã€ããé€å»ããåŸãå šéã500mlãšãããã
ã®ããã«ããŠåŸãããã³ã¢ä¹³å€500mlã60âã«å¶
埡ããæªæããªãããéïŒã¢ã«åœãïŒmgã®ã«ãªãŠ
ã ãããµã¯ããã€ãªããŒããæ·»å ãããã®åŸç¡é ž
éã®ïŒã¢ã«æ°Žæº¶æ¶²100mlãšå¡©åã«ãªãŠã ã®2.1ã¢ã«
氎溶液100mlãåæã«ïŒåéã§æ·»å ããããšã«ã
ã€ãŠå¡©åéã·ãšã«ãæ²æŸ±ãããããã«10åéã®ç©
ççæãè¡ãªã€ãåŸæ°ŽæŽãããåŸãããä¹³å€ãä¹³
å€âãšããã å®æœäŸ ïŒ ä¹³å€âãšåæ§ã®æ¹æ³ã§èª¿è£œãè¡ãªã€ããäœ
ãããããµã¯ããã€ãªããŒããæ·»å ããåŸãïŒâ
ããããã·âïŒïŒïŒïŒ3aïŒïŒâããã©ã¶ã€ã³ã
ã³ãéïŒã¢ã«åœã50mgæ·»å ãã次ãã§ãèåéã·
ãšã«ãæ²æŸ±ãããããã«ãå¡©åã«ãªãŠã ã®æ°Žæº¶æ¶²
ã®ãããã«èåã«ãªãŠã ã®2.1ã¢ã«æ°Žæº¶æ¶²100mlã
æ·»å ãããåŸãããä¹³å€ããä¹³å€âãšããã å®æœäŸ ïŒ ä¹³å€âãšåæ§ã®æ¹æ³ã§èª¿è£œãè¡ãªã€ããäœ
ããé žæ§æ¡ä»¶äžã§æ²æŸ±ãè¡ãªããã«ãªãŠã ãããµ
ã¯ããã€ãªããŒãã®ãããã«ç¡é žéãéïŒã¢ã«åœ
ã100mgæ·»å ãããåŸãããä¹³å€ãä¹³å€âãšã
ãã å®æœäŸ ïŒ åèšæ¯èŒäŸïŒãïŒåã³å®æœäŸâïŒãïŒã§èª¿è£œã
ãä¹³å€âããä¹³å€âã«ãã«ããªå€ãšããŠãïŒ
âãïŒâïŒïŒâããªã«ãã«ããã©ãžãïŒããšãã«ã
âïŒâããšãããªå°¿çŽ ãæ·»å ããé©åœãªå»¶å±å€å
ã³ç¡¬èå€ãå ããåŸãå¡åžéé35mgïŒ100cm2ãšãª
ãããã«ã»ã«ããŒã¹ããªã¢ã»ããŒãæ¯æäœäžã«å¡
åžã也ç¥ããã ãããã®è©Šæãæå èšãçšããŠã»ã³ã·ãã¡ããª
ãŒçšå åŠãŠãšããžãéããŠé²å ãã次ã®åŠæ¹ã®çŸ
å液ã§çŸåãã次ãã§å®çãæ°ŽæŽã也ç¥ãããçŸ
åã¯ã24âïŒåéãåã³18âïŒåéè¡ãªã€ãã ããšããã³ 0.4ïœ äºç¡«é žãœãŒãïŒç¡æ°ŽïŒ 75 ïœ ãã€ããããã³ 10 çé žãœãŒãïŒïŒæ°Žå¡©ïŒ 40 èåã«ãªãŠã ïŒ ïœ ïŒâã¡ãã«ãã³ãŸããªã¢ãŸãŒã« 10 mg æ°Žãå ããŠ ïŒ ïŒæ°Žé žåãããªãŠã ã§PH12.5ã«èª¿è£œããïŒ åŸãããããžç»åã«ã€ããŠæ倧æ¿åºŠããã³æå°
æ¿åºŠã枬å®ããçµæãè¡šâïŒã«ç€ºãã
ãè¡šã
è¡šâïŒã®çµæãããæ¬çºæã®ä¹³å€ã¯ãæ¯èŒã®ä¹³
å€ã«æ¯ã¹åŠç枩床ãå€åããŠãè¯å¥œãªåçæ§èœã
äŸæããŠããã®ããããã å®æœäŸ ïŒ å®æœäŸâïŒã§åŸãããè©Šæã«æ¬¡ã®åŠçãæœã
ããå³ã¡ãåè©Šæã«ã€ããŠæž©åºŠ20âãçžå¯Ÿæ¹¿åºŠ55
ïŒ ã§ïŒæ¥éä¿åïŒæ¡ä»¶âïŒãšããïŒã枩床55âã
çžå¯Ÿæ¹¿åºŠ10ïŒ ã§ïŒæ¥éä¿åïŒæ¡ä»¶âïŒãšããïŒã
ãã³æž©åºŠ50âãçžå¯Ÿæ¹¿åºŠ80ïŒ ã§ïŒæ¥éä¿åïŒæ¡ä»¶
âïŒãšããïŒããåŸãå®æœäŸâïŒã«æºããŠé²å
ãã24âïŒåéçŸåããæ°ŽæŽãæ°ŽæŽã也ç¥ããã
åŸãããçµæãè¡šâïŒã«ç€ºãã
å€ã«æ¯ã¹åŠç枩床ãå€åããŠãè¯å¥œãªåçæ§èœã
äŸæããŠããã®ããããã å®æœäŸ ïŒ å®æœäŸâïŒã§åŸãããè©Šæã«æ¬¡ã®åŠçãæœã
ããå³ã¡ãåè©Šæã«ã€ããŠæž©åºŠ20âãçžå¯Ÿæ¹¿åºŠ55
ïŒ ã§ïŒæ¥éä¿åïŒæ¡ä»¶âïŒãšããïŒã枩床55âã
çžå¯Ÿæ¹¿åºŠ10ïŒ ã§ïŒæ¥éä¿åïŒæ¡ä»¶âïŒãšããïŒã
ãã³æž©åºŠ50âãçžå¯Ÿæ¹¿åºŠ80ïŒ ã§ïŒæ¥éä¿åïŒæ¡ä»¶
âïŒãšããïŒããåŸãå®æœäŸâïŒã«æºããŠé²å
ãã24âïŒåéçŸåããæ°ŽæŽãæ°ŽæŽã也ç¥ããã
åŸãããçµæãè¡šâïŒã«ç€ºãã
ãè¡šã
è¡šâïŒã®çµæãããæ¬çºæã®ä¹³å€ã¯ãä¹³å€ïŒ¡ïŒ
ïŒïŒ£ïŒïŒ€ã«æ¯ã¹ãèããä¿åå®å®æ§ãæ¹è¯ãã
ãŠããããšããããã å®æœäŸ ïŒ æ¯èŒäŸïŒãïŒåã³å®æœäŸâïŒãïŒã§èª¿è£œããä¹³
å€âãã«ãããã次ã®å¢æè²çŽ ãæ·»å ããã ãŸããããŒã³ã¿ã«ãã©ãŒã®ïŒâïŒïŒïŒïŒïŒïŒâ
ããªã¯ããããšãã«ïŒâïŒâïŒïŒâã¯ããâïŒâãª
ã¯ã¿ãã·ã«ãµã¯ã·ã³ã€ããã¢ããªãïŒâïŒâãã©
ãŸãã³ããžããã«ãã¿ã¬ãŒãããã³é ¢é žãšãã«ã«
溶解ãããŒã©ãã³æ°Žæº¶æ¶²ã«åæ£ããä¹³å液ã調補
ããã 次ã«ããããã®ä¹³ååæ£æ¶²ãäžèšã®ä¹³å€ã«ãã
ããæ·»å ãæ··åãã硬èå€ãå ããŠãå¡åžééã
20mgïŒ100cm2ãšãªãããã«ã»ã«ããŒã¹ããªã¢ã»ã
ãŒãæ¯æäœäžã«å¡åžã也ç¥ããã ãããã®è©Šæããé»è²ãã€ã«ã¿ãŒåã³å åŠãŠãš
ããžãéããŠé²å ãã次ã®åŠæ¹ã®çŸå液ã§30âïŒ
åéçŸåããã ïŒâã¢ããâïŒâã¡ãã«ââãšãã« ââïŒÎ²âã¡ã¿ã³ã¹ã«ããªã³ã¢ãã
ãšãã«ïŒã¢ããªã³ç¡«é žå¡© ïŒïœ äºç¡«é žãããªãŠã ïŒç¡æ°ŽïŒ ïŒïœ çé žãããªãŠã ïŒäžæ°Žå¡©ïŒ 15ïœ èåã«ãªãŠã ïŒïœ ãã³ãžã«ã¢ã«ã³ãŒã« 10ml æ°Žãå ããŠ ïŒ äœããçŸåéå§åŸ30ç§åŸããïŒåéãïŒã«ãã¯
ã¹ã®çœè²å ã§å šé¢ãåäžã«é²å ããã次ãã§éåžž
ã®æ¹æ³ã«åŸã€ãŠæŒçœãå®çãæ°ŽæŽããŠä¹Ÿç¥ããã
åè©Šæã«ãããŠåŸãããããŒã³ã¿ããžç»åã«ã€ã
ãŠæž¬å®ããçµæãè¡šâïŒã«ç€ºãã
ïŒïŒ£ïŒïŒ€ã«æ¯ã¹ãèããä¿åå®å®æ§ãæ¹è¯ãã
ãŠããããšããããã å®æœäŸ ïŒ æ¯èŒäŸïŒãïŒåã³å®æœäŸâïŒãïŒã§èª¿è£œããä¹³
å€âãã«ãããã次ã®å¢æè²çŽ ãæ·»å ããã ãŸããããŒã³ã¿ã«ãã©ãŒã®ïŒâïŒïŒïŒïŒïŒïŒâ
ããªã¯ããããšãã«ïŒâïŒâïŒïŒâã¯ããâïŒâãª
ã¯ã¿ãã·ã«ãµã¯ã·ã³ã€ããã¢ããªãïŒâïŒâãã©
ãŸãã³ããžããã«ãã¿ã¬ãŒãããã³é ¢é žãšãã«ã«
溶解ãããŒã©ãã³æ°Žæº¶æ¶²ã«åæ£ããä¹³å液ã調補
ããã 次ã«ããããã®ä¹³ååæ£æ¶²ãäžèšã®ä¹³å€ã«ãã
ããæ·»å ãæ··åãã硬èå€ãå ããŠãå¡åžééã
20mgïŒ100cm2ãšãªãããã«ã»ã«ããŒã¹ããªã¢ã»ã
ãŒãæ¯æäœäžã«å¡åžã也ç¥ããã ãããã®è©Šæããé»è²ãã€ã«ã¿ãŒåã³å åŠãŠãš
ããžãéããŠé²å ãã次ã®åŠæ¹ã®çŸå液ã§30âïŒ
åéçŸåããã ïŒâã¢ããâïŒâã¡ãã«ââãšãã« ââïŒÎ²âã¡ã¿ã³ã¹ã«ããªã³ã¢ãã
ãšãã«ïŒã¢ããªã³ç¡«é žå¡© ïŒïœ äºç¡«é žãããªãŠã ïŒç¡æ°ŽïŒ ïŒïœ çé žãããªãŠã ïŒäžæ°Žå¡©ïŒ 15ïœ èåã«ãªãŠã ïŒïœ ãã³ãžã«ã¢ã«ã³ãŒã« 10ml æ°Žãå ããŠ ïŒ äœããçŸåéå§åŸ30ç§åŸããïŒåéãïŒã«ãã¯
ã¹ã®çœè²å ã§å šé¢ãåäžã«é²å ããã次ãã§éåžž
ã®æ¹æ³ã«åŸã€ãŠæŒçœãå®çãæ°ŽæŽããŠä¹Ÿç¥ããã
åè©Šæã«ãããŠåŸãããããŒã³ã¿ããžç»åã«ã€ã
ãŠæž¬å®ããçµæãè¡šâïŒã«ç€ºãã
ãè¡šã
ãè¡šã
æ¬çºæã®ä¹³å€ããæãè©Šæ5â²ïŒ6â²åã³7â²ãè¯å¥œ
ãªåçæ§èœã瀺ããŠããããšããããã å®æœäŸ ïŒ å®æœäŸâïŒã§èª¿è£œããEmâãïŒåå²ããã
ã®äžéšãäžèšã®è²çŽ ãããçšããŠåå å¢æãã
èµ€ææ§ä¹³å€ãšããå¥ã®äžéšã¯è²çŽ ããã§åå å¢
æããç·ææ§ä¹³å€ãšããããã«å¥ã®äžéšã¯ãè²çŽ
ãããå ããéæä¹³å€ãšããã èµ€ææ§ä¹³å€ãç·ææ§ä¹³å€åã³éææ§ä¹³å€ã®ãã
ããã«ãã«ããªå€ãšããŠãïŒâãïŒâïŒïŒâããªã«
ãã«ããã©ãžãïŒããšãã«ãâïŒâããšãã«ããª
å°¿çŽ åã³ïŒâãã«ãã«âïŒâïŒïŒâã¡ãã«ããšã
ã«ïŒããã©ãžã³ãæ·»å ããã ã¬ãžã³ã³ãŒãããçŽæ¯æäœäžã«äžèšã®å±€ãé 次
å¡åžããã (1) èµ€æå±€ äžèšã®èµ€ææ§ä¹³å€ãšãªã€ã«ãããã¯ãåæ£ãã
ãã·ã¢ã³ã«ãã©ãŒïŒïŒïŒâãžã¯ããâïŒâã¡ãã«
âïŒâãαâïŒïŒïŒïŒâãžâtertâã¢ãã«ããšãã
ã·ïŒããã«ã¢ãããããšããŒã«ãå«ãã (2) äžéå±€ ãªã€ã«ãããã¯ãåæ£ãããïŒïŒïŒâãžâtert
âãªã¯ãã«ãã€ããããã³ãå«ãã (3) ç·æå±€ äžèšã®ç·ææ§ä¹³å€ãšãªã€ã«ãããã¯ãåæ£ãã
ãããŒã³ã¿ã«ãã©ãŒïŒâïŒïŒïŒïŒïŒïŒâããªã¯ã
ãããšãã«ïŒâïŒâïŒïŒâã¯ããâïŒâãªã¯ã¿ãã·
ã«ã¹ã¯ã·ã³ã€ããã¢ããªãïŒâïŒâãã©ãŸãã³ã
å«ãã (4) ã€ãšããŒãã€ã«ã¿ãŒå±€ ã€ãšããŒã³ãã€ãéåã³ãªã€ã«ãããã¯ãåæ£
ãããïŒïŒïŒâãžâtertâãªã¯ãã«ãã€ãããã
ã³ãå«ãã (5) éæå±€ äžèšã®éææ§ä¹³å€ãšãªã€ã«ãããã¯ãåæ£ãã
ãã€ãšããŒã«ãã©ãŒÎ±âãïŒâïŒïŒâãã³ãžã«âïŒ
âããšãã«âïŒïŒïŒâãžãªããœâïŒïŒïŒïŒïŒâã
ãªã¢ãŸãªãžãã«ïŒãâαâãããªã«âïŒâã¯ããâ
ïŒâãγâïŒïŒïŒïŒâãžâtertâã¢ãã«ããšãã
ã·ïŒããã«ã¢ãããã¢ã»ãã¢ããªããå«ãã (6) ä¿è·å±€ 也ç¥åŸã®è©Šæãå åŠãŠãšããžãéããŠé²å ãã
次ã«ç€ºãçŸå液ã§30âïŒåéçŸåããæŒçœãå®
çãæ°ŽæŽããŠä¹Ÿç¥ããã ïŒâã¢ããâïŒâã¡ãã«ââãšãã« ââïŒÎ²âã¡ã¿ã³ã¹ã«ããªã³ã¢ãã
ãšãã«ïŒã¢ããªã³ç¡«é žå¡© ïŒïœ äºç¡«é žãããªãŠã ïŒç¡æ°ŽïŒ ïŒïœ çé žãããªãŠã ïŒäžæ°Žå¡©ïŒ 15ïœ èåã«ãªãŠã ïŒïœ ïŒâã¡ãã«âãã³ãŸããªã¢ãŸãŒã« 10mg æ°Žãå ããŠ ïŒ ïŒæ°Žé žåãããªãŠã ã«ãŠPH12.5ã«èª¿è£œããïŒ ãã®çµæãè¯å¥œãªããžç»åãåŸãããã å®æœäŸ ïŒ éæãªããªãšãã¬ã³ãã¬ãã¿ã¬ãŒãã®æ¯æäœäž
ã«äžèšã®å±€ãé 次å¡åžããŠæ¡æ£è»¢åæå ææã®å
çèŠçŽ ãäœæããã (1) ã¹ãã¬ã³ãšïŒ®âããã«ãã³ãžã«âïŒïŒ®ïŒïŒ®
âããªããã·ã«ã¢ã³ã¢ããŠã ã¯ãã©ã€ãã®ïŒïŒ
ïŒã®å ±éåäœåã³ãŒã©ãã³ãæããååå±€ã (2) äºé žåãã¿ã³åã³ãŒã©ãã³ãæããå åå°
å±€ã (3) ã«ãŒãã³ãã©ãã¯åã³ãŒã©ãã³ã®äžéæå±€ã (4) ããŒã³ã¿è²çŽ æŸåºæ§ååç©ãïŒâããããã·
âïŒãïŒâïœÎ±âïŒïŒâïŒïŒâã¡ããã·âïŒâã¹ã«
ãã¢ã¢ã€ã«âïŒâã¢ãŸïŒâïŒâããããã·âïŒ
âããããã·ïŒãšãã«ã«ã«ãã¢ã€ã«ïœããšãã«
ã¹ã«ããªã³ã¢ãããââïŒÎŽâïŒïŒïŒâãžâ
tertâã¢ããããšããã·ããã«ïŒâïŒâããã
ã¢ãããïŒïŒ®âãžãšãã«ã©ãŠãªã«ã¢ããåã³
ãŒã©ãã³ãæããè²çŽ æŸåºæ§ååç©å±€ã (5) å®æœäŸïŒã§èª¿è£œããä¹³å€âãïŒâãã«ãã«
âïŒâïŒïŒâã¡ãã«ããšãã«ïŒããã©ãžã³åã³
ãŒã©ãã³ãæããæå ä¹³å€å±€ã (6) ã ã³ã¯ãã«é žãå«ããŒã©ãã³ã®ä¿è·å±€ã 次ã«éæãªããªãšãã¬ã³ãã¬ãã¿ã¬ãŒãæ¯æäœ
äžã«ãäžèšã®å±€ãé 次å¡åžãåŠçã·ãŒããçšæã
ãã (1) ã¢ã¯ãªã«é žãšãšãã«ã¢ã¯ãªã¬ãŒãã®å ±éåäœ
ãæããäžåå±€ã (2) äºé ¢é žã»ã«ããŒã¹ã®ã¿ã€ãã³ã°å±€ã 次ã«ãäžèšã®æå èŠçŽ ã«ãŠãšããžé²å ãäžãã
ãã®åŸäžèšåŠçã·ãŒããéãåãããæŽã«ãã®é
ã«äžèšçµæã®åŠççµæç©ãå«ãããããéçã
ãããã€ã«ã åäœãäœã€ãã 次ã«äžèšãã€ã«ã åäœããäžå¯Ÿã®å å§çã«äžŠçœ®
ãããäžå®ã®ééãæããããŒã©ãŒã®éãééã
ããããšã«ããããããç Žè£ããããã®å 容ç©ã
äžèšåçèŠçŽ ãšåŠçã·ãŒãã®éã«å±éãããã æ°Žé žåã«ãªãŠã 56 ïœ äºç¡«é žãããªãŠã ïŒ ïœ ïŒâããããã·ã¡ãã«âïŒâã¡ãã«âïŒâã
ãšãã«âïŒâãã©ãŸãªãã³ ïŒ ïœ ïŒâã¡ãã«ãã³ãŸããªã¢ãŸãŒã« 2.8ïœ ã«ãŒãã³ãã©ãã¯ïŒRaVENâ450ã³ãã³ã
ã¢ã³ã»ã«ãŒãã³è£œïŒ 150 ïœ ã«ã«ããã·ã»ã¡ãã«ã»ã«ããŒã¹ãããªãŠã å¡©
ïŒé«ç²åºŠåãæ±äº¬åæè£œïŒ 50 ïœ ãã³ãžã«ã¢ã«ã³ãŒã« 1.5ml æ°Žãå ããŠ ïŒ ïŒååŸã«ããŒã³ã¿è²çŽ ç»åãåçèŠçŽ ã®éææ¯
æäœãéããŠèŠ³æž¬ãããããã®çµæãããæ¬çºæ
ã®ä¹³å€ãæ¡æ£è»¢åæ³ã«ãå¿çšãåŸãããšããã
ãã
ãªåçæ§èœã瀺ããŠããããšããããã å®æœäŸ ïŒ å®æœäŸâïŒã§èª¿è£œããEmâãïŒåå²ããã
ã®äžéšãäžèšã®è²çŽ ãããçšããŠåå å¢æãã
èµ€ææ§ä¹³å€ãšããå¥ã®äžéšã¯è²çŽ ããã§åå å¢
æããç·ææ§ä¹³å€ãšããããã«å¥ã®äžéšã¯ãè²çŽ
ãããå ããéæä¹³å€ãšããã èµ€ææ§ä¹³å€ãç·ææ§ä¹³å€åã³éææ§ä¹³å€ã®ãã
ããã«ãã«ããªå€ãšããŠãïŒâãïŒâïŒïŒâããªã«
ãã«ããã©ãžãïŒããšãã«ãâïŒâããšãã«ããª
å°¿çŽ åã³ïŒâãã«ãã«âïŒâïŒïŒâã¡ãã«ããšã
ã«ïŒããã©ãžã³ãæ·»å ããã ã¬ãžã³ã³ãŒãããçŽæ¯æäœäžã«äžèšã®å±€ãé 次
å¡åžããã (1) èµ€æå±€ äžèšã®èµ€ææ§ä¹³å€ãšãªã€ã«ãããã¯ãåæ£ãã
ãã·ã¢ã³ã«ãã©ãŒïŒïŒïŒâãžã¯ããâïŒâã¡ãã«
âïŒâãαâïŒïŒïŒïŒâãžâtertâã¢ãã«ããšãã
ã·ïŒããã«ã¢ãããããšããŒã«ãå«ãã (2) äžéå±€ ãªã€ã«ãããã¯ãåæ£ãããïŒïŒïŒâãžâtert
âãªã¯ãã«ãã€ããããã³ãå«ãã (3) ç·æå±€ äžèšã®ç·ææ§ä¹³å€ãšãªã€ã«ãããã¯ãåæ£ãã
ãããŒã³ã¿ã«ãã©ãŒïŒâïŒïŒïŒïŒïŒïŒâããªã¯ã
ãããšãã«ïŒâïŒâïŒïŒâã¯ããâïŒâãªã¯ã¿ãã·
ã«ã¹ã¯ã·ã³ã€ããã¢ããªãïŒâïŒâãã©ãŸãã³ã
å«ãã (4) ã€ãšããŒãã€ã«ã¿ãŒå±€ ã€ãšããŒã³ãã€ãéåã³ãªã€ã«ãããã¯ãåæ£
ãããïŒïŒïŒâãžâtertâãªã¯ãã«ãã€ãããã
ã³ãå«ãã (5) éæå±€ äžèšã®éææ§ä¹³å€ãšãªã€ã«ãããã¯ãåæ£ãã
ãã€ãšããŒã«ãã©ãŒÎ±âãïŒâïŒïŒâãã³ãžã«âïŒ
âããšãã«âïŒïŒïŒâãžãªããœâïŒïŒïŒïŒïŒâã
ãªã¢ãŸãªãžãã«ïŒãâαâãããªã«âïŒâã¯ããâ
ïŒâãγâïŒïŒïŒïŒâãžâtertâã¢ãã«ããšãã
ã·ïŒããã«ã¢ãããã¢ã»ãã¢ããªããå«ãã (6) ä¿è·å±€ 也ç¥åŸã®è©Šæãå åŠãŠãšããžãéããŠé²å ãã
次ã«ç€ºãçŸå液ã§30âïŒåéçŸåããæŒçœãå®
çãæ°ŽæŽããŠä¹Ÿç¥ããã ïŒâã¢ããâïŒâã¡ãã«ââãšãã« ââïŒÎ²âã¡ã¿ã³ã¹ã«ããªã³ã¢ãã
ãšãã«ïŒã¢ããªã³ç¡«é žå¡© ïŒïœ äºç¡«é žãããªãŠã ïŒç¡æ°ŽïŒ ïŒïœ çé žãããªãŠã ïŒäžæ°Žå¡©ïŒ 15ïœ èåã«ãªãŠã ïŒïœ ïŒâã¡ãã«âãã³ãŸããªã¢ãŸãŒã« 10mg æ°Žãå ããŠ ïŒ ïŒæ°Žé žåãããªãŠã ã«ãŠPH12.5ã«èª¿è£œããïŒ ãã®çµæãè¯å¥œãªããžç»åãåŸãããã å®æœäŸ ïŒ éæãªããªãšãã¬ã³ãã¬ãã¿ã¬ãŒãã®æ¯æäœäž
ã«äžèšã®å±€ãé 次å¡åžããŠæ¡æ£è»¢åæå ææã®å
çèŠçŽ ãäœæããã (1) ã¹ãã¬ã³ãšïŒ®âããã«ãã³ãžã«âïŒïŒ®ïŒïŒ®
âããªããã·ã«ã¢ã³ã¢ããŠã ã¯ãã©ã€ãã®ïŒïŒ
ïŒã®å ±éåäœåã³ãŒã©ãã³ãæããååå±€ã (2) äºé žåãã¿ã³åã³ãŒã©ãã³ãæããå åå°
å±€ã (3) ã«ãŒãã³ãã©ãã¯åã³ãŒã©ãã³ã®äžéæå±€ã (4) ããŒã³ã¿è²çŽ æŸåºæ§ååç©ãïŒâããããã·
âïŒãïŒâïœÎ±âïŒïŒâïŒïŒâã¡ããã·âïŒâã¹ã«
ãã¢ã¢ã€ã«âïŒâã¢ãŸïŒâïŒâããããã·âïŒ
âããããã·ïŒãšãã«ã«ã«ãã¢ã€ã«ïœããšãã«
ã¹ã«ããªã³ã¢ãããââïŒÎŽâïŒïŒïŒâãžâ
tertâã¢ããããšããã·ããã«ïŒâïŒâããã
ã¢ãããïŒïŒ®âãžãšãã«ã©ãŠãªã«ã¢ããåã³
ãŒã©ãã³ãæããè²çŽ æŸåºæ§ååç©å±€ã (5) å®æœäŸïŒã§èª¿è£œããä¹³å€âãïŒâãã«ãã«
âïŒâïŒïŒâã¡ãã«ããšãã«ïŒããã©ãžã³åã³
ãŒã©ãã³ãæããæå ä¹³å€å±€ã (6) ã ã³ã¯ãã«é žãå«ããŒã©ãã³ã®ä¿è·å±€ã 次ã«éæãªããªãšãã¬ã³ãã¬ãã¿ã¬ãŒãæ¯æäœ
äžã«ãäžèšã®å±€ãé 次å¡åžãåŠçã·ãŒããçšæã
ãã (1) ã¢ã¯ãªã«é žãšãšãã«ã¢ã¯ãªã¬ãŒãã®å ±éåäœ
ãæããäžåå±€ã (2) äºé ¢é žã»ã«ããŒã¹ã®ã¿ã€ãã³ã°å±€ã 次ã«ãäžèšã®æå èŠçŽ ã«ãŠãšããžé²å ãäžãã
ãã®åŸäžèšåŠçã·ãŒããéãåãããæŽã«ãã®é
ã«äžèšçµæã®åŠççµæç©ãå«ãããããéçã
ãããã€ã«ã åäœãäœã€ãã 次ã«äžèšãã€ã«ã åäœããäžå¯Ÿã®å å§çã«äžŠçœ®
ãããäžå®ã®ééãæããããŒã©ãŒã®éãééã
ããããšã«ããããããç Žè£ããããã®å 容ç©ã
äžèšåçèŠçŽ ãšåŠçã·ãŒãã®éã«å±éãããã æ°Žé žåã«ãªãŠã 56 ïœ äºç¡«é žãããªãŠã ïŒ ïœ ïŒâããããã·ã¡ãã«âïŒâã¡ãã«âïŒâã
ãšãã«âïŒâãã©ãŸãªãã³ ïŒ ïœ ïŒâã¡ãã«ãã³ãŸããªã¢ãŸãŒã« 2.8ïœ ã«ãŒãã³ãã©ãã¯ïŒRaVENâ450ã³ãã³ã
ã¢ã³ã»ã«ãŒãã³è£œïŒ 150 ïœ ã«ã«ããã·ã»ã¡ãã«ã»ã«ããŒã¹ãããªãŠã å¡©
ïŒé«ç²åºŠåãæ±äº¬åæè£œïŒ 50 ïœ ãã³ãžã«ã¢ã«ã³ãŒã« 1.5ml æ°Žãå ããŠ ïŒ ïŒååŸã«ããŒã³ã¿è²çŽ ç»åãåçèŠçŽ ã®éææ¯
æäœãéããŠèŠ³æž¬ãããããã®çµæãããæ¬çºæ
ã®ä¹³å€ãæ¡æ£è»¢åæ³ã«ãå¿çšãåŸãããšããã
ãã
Claims (1)
- ïŒ å éšæœååããã²ã³åéç²åãå«æãããã
ã²ã³åéä¹³å€å±€ãæããé転çŸåãŸãã¯ç §å°çŸå
ã«ãã€ãŠããžåç»åãäžããããã²ã³åéåçèŠ
çŽ ã«æŒãŠã該ããã²ã³åéç²åãäºããã®è¡šé¢ã«
è¡šé¢çŸåæ žãæãããå€æåããã²ã³åéç²åã
ã³ã¢ãšããã³ã¢ïŒã·ãšã«åç²åã§ãããäžã€è©²ç²
åå éšã«å€äŸ¡éå±ã€ãªã³ãå èµããããšãç¹åŸŽãš
ããããã²ã³åéåçèŠçŽ ã
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12222484A JPS612148A (ja) | 1984-06-13 | 1984-06-13 | ããã²ã³åéåçèŠçŽ |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12222484A JPS612148A (ja) | 1984-06-13 | 1984-06-13 | ããã²ã³åéåçèŠçŽ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPS612148A JPS612148A (ja) | 1986-01-08 |
| JPH0511301B2 true JPH0511301B2 (ja) | 1993-02-15 |
Family
ID=14830631
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP12222484A Granted JPS612148A (ja) | 1984-06-13 | 1984-06-13 | ããã²ã³åéåçèŠçŽ |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JPS612148A (ja) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH063529B2 (ja) * | 1985-07-04 | 1994-01-12 | å¯å£«åçãã€ã«ã æ ªåŒäŒç€Ÿ | ãã¬åããã²ã³åéåçä¹³å€ |
| JPH0420879Y2 (ja) * | 1985-12-27 | 1992-05-13 | ||
| JPH0823679B2 (ja) * | 1986-06-30 | 1996-03-06 | å¯å£«åçãã€ã«ã æ ªåŒäŒç€Ÿ | çŽæ¥ããžç»åã®åœ¢ææ¹æ³ |
| JPH0823681B2 (ja) * | 1986-09-18 | 1996-03-06 | å¯å£«åçãã€ã«ã æ ªåŒäŒç€Ÿ | çŽæ¥ããžã«ã©âç»å圢ææ¹æ³ |
| JPH0823682B2 (ja) * | 1986-09-24 | 1996-03-06 | å¯å£«åçãã€ã«ã æ ªåŒäŒç€Ÿ | çŽæ¥ããžç»å圢ææ¹æ³ |
| JPH0782210B2 (ja) * | 1987-06-24 | 1995-09-06 | å¯å£«åçãã€ã«ã æ ªåŒäŒç€Ÿ | ãã¬åããã²ã³åéåçä¹³å€ |
| JPS6465544A (en) * | 1987-09-07 | 1989-03-10 | Konishiroku Photo Ind | Positive image forming method |
| JPH0820694B2 (ja) * | 1987-10-16 | 1996-03-04 | å¯å£«åçãã€ã«ã æ ªåŒäŒç€Ÿ | ããã²ã³åéåçä¹³å€ |
| JP2514056B2 (ja) * | 1987-12-18 | 1996-07-10 | å¯å£«åçãã€ã«ã æ ªåŒäŒç€Ÿ | ããã²ã³åéåçä¹³å€ |
| JPH01123227A (ja) * | 1987-11-07 | 1989-05-16 | Konica Corp | çŽæ¥ããžããã²ã³åéåçæå ææåã³è©²æå ææãçšããç»å圢ææ¹æ³ |
-
1984
- 1984-06-13 JP JP12222484A patent/JPS612148A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS612148A (ja) | 1986-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4863838A (en) | Direct positive type light-sensitive silver halide photographic materials | |
| JPH07113744B2 (ja) | ããã²ã³åéåçæå ææ | |
| JPH0511301B2 (ja) | ||
| US4917991A (en) | Direct positive silver halide photographic material | |
| US4150993A (en) | Process for forming a direct positive image | |
| EP0278666B1 (en) | Method of making a direct positive silver halide light- sensitive photographic material | |
| JPH0542655B2 (ja) | ||
| US4904580A (en) | Silver halide photographic light-sensitive material | |
| JPH0310930B2 (ja) | ||
| JPH0619512B2 (ja) | çŽæ¥ããžããã²ã³åéåçæå ææ | |
| JPS5814666B2 (ja) | çŽæ¥ããžããã²ã³åéåçæå ææ | |
| JPH0619511B2 (ja) | çŽæ¥ããžããã²ã³åéåçæå ææ | |
| JPH0642039B2 (ja) | çŽæ¥ããžç»åã®åœ¢ææ¹æ³ | |
| JPH0473770B2 (ja) | ||
| JPH0577058B2 (ja) | ||
| JP2613425B2 (ja) | ããã²ã³åéåçæå ææ | |
| JPS5843735B2 (ja) | çŽæ¥ããžç»åã®åœ¢ææ¹æ³ | |
| JPH0581021B2 (ja) | ||
| JPS586936B2 (ja) | çŽæ¥ããžç»å圢ææ¹æ³ | |
| JPH0690429B2 (ja) | çŽæ¥ããžåããã²ã³åéåçæå ææ | |
| JPS62215269A (ja) | çŽæ¥ããžç»åã®åœ¢ææ¹æ³ | |
| JPS583536B2 (ja) | çŽæ¥ããžåããã²ã³åéåçæå ææ | |
| JPS60247237A (ja) | ããã²ã³åéåçæå ææ | |
| JPH0833606B2 (ja) | çŽæ¥ããžããã²ã³åéã«ã©âåçæå ææ | |
| JPS61264336A (ja) | çŽæ¥ããžããã²ã³åéåçæå ææ |