JPH0359063B2 - - Google Patents

Info

Publication number: JPH0359063B2
Authority: JP; Japan
Prior art keywords: dihydroxycholecalciferol; monohydrate; methanol; water; present
Prior art date: 1982-12-03
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

JP57211369A

Other languages

English (en)

Japanese (ja)

Other versions

JPS59104358A (ja

Inventor

Kenji Ishimaru

Junichi Oshida

Tooru Takeshita

Hideki Tsuruta

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Teijin Ltd

Original Assignee

Teijin Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-12-03

Filing date

1982-12-03

Publication date

1991-09-09

1982-12-03 Application filed by Teijin Ltd filed Critical Teijin Ltd

1982-12-03 Priority to JP21136982A priority Critical patent/JPS59104358A/ja

1984-06-16 Publication of JPS59104358A publication Critical patent/JPS59104358A/ja

1991-09-09 Publication of JPH0359063B2 publication Critical patent/JPH0359063B2/ja

Status Granted legal-status Critical Current

Links

OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 39
BJYLYJCXYAMOFT-RRXOBRNQSA-N (1r,3s,5z)-5-[(2e)-2-[(1r,3as,7ar)-1-[(2r)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1h-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCC(O)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C BJYLYJCXYAMOFT-RRXOBRNQSA-N 0.000 claims description 21
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
-1 1α,24-dihydroxycholecalciferol monohydrate Chemical class 0.000 claims description 6
238000000034 method Methods 0.000 claims description 5
150000004682 monohydrates Chemical class 0.000 claims description 5
238000004519 manufacturing process Methods 0.000 claims description 4
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
150000001875 compounds Chemical class 0.000 description 7
239000013078 crystal Substances 0.000 description 7
239000002904 solvent Substances 0.000 description 5
239000000126 substance Substances 0.000 description 5
GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 4
239000012153 distilled water Substances 0.000 description 4
UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
235000020964 calcitriol Nutrition 0.000 description 3
239000011612 calcitriol Substances 0.000 description 3
239000003814 drug Substances 0.000 description 3
230000000694 effects Effects 0.000 description 3
239000000203 mixture Substances 0.000 description 3
230000000704 physical effect Effects 0.000 description 3
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
210000000988 bone and bone Anatomy 0.000 description 2
239000011575 calcium Substances 0.000 description 2
229910052791 calcium Inorganic materials 0.000 description 2
229910052500 inorganic mineral Inorganic materials 0.000 description 2
239000011707 mineral Substances 0.000 description 2
210000000813 small intestine Anatomy 0.000 description 2
206010061728 Bone lesion Diseases 0.000 description 1
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 1
208000000038 Hypoparathyroidism Diseases 0.000 description 1
208000001647 Renal Insufficiency Diseases 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
238000002441 X-ray diffraction Methods 0.000 description 1
230000002159 abnormal effect Effects 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
CSCPPACGZOOCGX-WFGJKAKNSA-N acetone d6 Chemical compound [2H]C([2H])([2H])C(=O)C([2H])([2H])[2H] CSCPPACGZOOCGX-WFGJKAKNSA-N 0.000 description 1
150000001298 alcohols Chemical class 0.000 description 1
229910052786 argon Inorganic materials 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
230000003913 calcium metabolism Effects 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
238000000921 elemental analysis Methods 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
201000006370 kidney failure Diseases 0.000 description 1
239000007788 liquid Substances 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000008188 pellet Substances 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
238000002360 preparation method Methods 0.000 description 1
238000000746 purification Methods 0.000 description 1
208000007442 rickets Diseases 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
150000003722 vitamin derivatives Chemical class 0.000 description 1

Landscapes

Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP21136982A 1982-12-03 1982-12-03 １α，２４−ジヒドロキシコレカルシフエロ−ルの一水塩及びその製造法 Granted JPS59104358A (ja)

Priority Applications (1)

Application Number	Priority Date	Filing Date	Title
JP21136982A JPS59104358A (ja)	1982-12-03	1982-12-03	１α，２４−ジヒドロキシコレカルシフエロ−ルの一水塩及びその製造法

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP21136982A JPS59104358A (ja)	1982-12-03	1982-12-03	１α，２４−ジヒドロキシコレカルシフエロ−ルの一水塩及びその製造法

Publications (2)

Publication Number	Publication Date
JPS59104358A JPS59104358A (ja)	1984-06-16
JPH0359063B2 true JPH0359063B2 (pt)	1991-09-09

Family

ID=16604820

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP21136982A Granted JPS59104358A (ja)	1982-12-03	1982-12-03	１α，２４−ジヒドロキシコレカルシフエロ−ルの一水塩及びその製造法

Country Status (1)

Country	Link
JP (1)	JPS59104358A (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR940010767B1 (ko) *	1985-08-02	1994-11-11	레오 파마슈티칼스 프로덕츠 리미티드 에이/에스(레벤스 케미스케 파브리크 프로덕션 사크티에셀스카브)	신규 비타민 d 동족체
USRE39706E1 (en)	1993-01-15	2007-06-26	Leo Pharma A/S	Crystalline form of a vitamin D analogue
JP2008084358A (ja) *	2006-09-25	2008-04-10	Pioneer Electronic Corp	記録媒体搬送方法
JP2012096996A (ja) *	2009-02-17	2012-05-24	Mercian Corp	ビタミンｄ誘導体の結晶化方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4934980A (pt) *	1972-08-04	1974-03-30
JPS5692266A (en) *	1979-12-27	1981-07-25	Teijin Ltd	Preparation of active vitamin d3

1982
- 1982-12-03 JP JP21136982A patent/JPS59104358A/ja active Granted

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS4934980A (pt) *	1972-08-04	1974-03-30
JPS5692266A (en) *	1979-12-27	1981-07-25	Teijin Ltd	Preparation of active vitamin d3

Also Published As

Publication number	Publication date
JPS59104358A (ja)	1984-06-16

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Legal Events

Date	Code	Title	Description
2005-06-08	EXPY	Cancellation because of completion of term