JPH03251518A - Skin, scalp and hair agent containing component of suppressing growth of dandruff fungus extracted from bamboo - Google Patents

Abstract

PURPOSE:To obtain a skin, scalp and hair agent effective for preventing and treating dandruff and itch on the skin and the scalp, having excellently inhibitory action on multiplication of dandruff fungi, containing a component of suppressing multiplication of dandruff fungi extracted from ground bamboo with a specific organic solvent. CONSTITUTION:Ground bamboo such as Phyllostachys bambusoides Sieb. et Zucc., Phyllostachys bambusoides Sieb. et Zucc. Var. aurea Makino, Phyllostachys pubescens Mazel, Phyllostachys nigra Munro var. henosis Starf or phyllostachys nigra Munro as a starting raw material is extracted with one or more organic solvents selected from benzene, chloroform, ether, ethyl acetate, n-butanol, acetone, ethanol and methanol to give a component of suppressing multiplication of dandruff fungi, which is blended as an essential component with an external preparation for skin, scalp and hair to give the external preparation or cosmetic having the above-mentioned effects, preventing effects on seborrheic eczema of the head and removal of hair, blood stream promoting effects on peripheral blood vessel of face and skin, inhibitory effects on formation of peroxide lipid, stabilizing effects on product and beautiful skin retaining effects (prevention of aging of skin).

Description

[Detailed Description of the Invention] "Object of the Invention" The present invention provides extracts obtained from bamboos of the Poaceae family (Madake, Hateichiku, Mousouchiku, Hachiku, etc.).
This invention relates to a novel application to cosmetics in the form of external application or rubbing on the skin, which contains a component that inhibits the growth of dandruff bacteria.

The dandruff fungus in the present invention refers to Pi tyrosporum, which belongs to yeast and is known to reside on the scalp.

Vale (hereinafter abbreviated as PO for convenience).

"Industrial Application Field" The growth-inhibiting component of PO made of bamboo extract according to the present invention can be incorporated into a dosage form (prescription) in the form of external application or rubbing to produce pharmaceuticals, quasi-drugs, and cosmetics. It can be used as

Its effects can prevent, prevent, and improve the onset of dandruff caused by PO and the accompanying itching. Furthermore, the PO growth-inhibiting component obtained according to the present invention has a strong antioxidant effect on fats and oils, and is effective, for example, in preventing rancidity of the fat and oil base used in the formulation.

``Conventional technology'' Various causes have been known to cause dandruff and itching on the skin and scalp, but one of them is closely related to PO, which is resident on the scalp. It is said that the prevalence is particularly high from adolescence to adulthood, and symptoms associated with dandruff and itching are known to increase in such cases.

Therefore, recently, drugs that inhibit or suppress the growth of PO are considered to be useful for effective prevention and treatment, and drugs that have a growth inhibiting effect on PO are being developed.

For example, according to research on sebum secretion, dandruff,
Or, when itching occurs due to dandruff, triglycerides in sebum infiltrate PO into the follicular canal, which accelerates the production of lipase, which increases the production of glycerol and free fatty acids. It has been found that excessive free fatty acids produced in the body have especially strong effects on surface saturation and inflammation.

Originally, PO is lipid-dependent and lipophilic, so as the amount of sebum increases and accumulates in the hair follicle canal, PO gradually increases.

In addition, destruction of the hair follicle epithelium by neutrophil chemotaxis and complement activation factors by PO, and protease, lipase, hyaluronidase, etc., which are products of the bacteria.
The induction of inflammation is also being considered as a new hypothesis.

In addition to the above factors, internal and external factors such as genetic factors, age, dietary factors, gastrointestinal disorders, stress, irregular menstruation, mechanical stimulation, and cosmetics are intricately related to each other. However, in any case, in the mechanism of occurrence of dandruff and itching, preventing the inhabitation (invasion and growth) of PO in the lesion is the key to preventing and treating dandruff and itching. considered to be very important.

Furthermore, dandruff consists of sebaceous gland secretions, sweat gland secretions, peeled substances from the epidermal layer, etc., and is usually caused by increased secretion of sebaceous glands, etc., and is also exacerbated by the proliferation of skin bacteria, especially PO. It is said that it will be done.

Therefore, scalp and hair cosmetics containing antibacterial agents and bactericidal agents that inhibit the growth of PO have traditionally been used to treat dandruff,
It has a history of being used to prevent itching. A typical example is the use of zinc pyrithione in hair shampoo.

However, not only zinc pyrithione, but many anti-dandruff antibacterial drugs are not universally effective, and some people are effective and some are not, and some people are not effective, and some people may not be effective after using it for about a week, or even longer. When used for a long period of time, some people show a tendency to increase dandruff, and one of the reasons for this is the amount of the compound, that is, its effectiveness. In some cases, on the other hand, dandruff may be increased.

Under these circumstances, recently, ingredients based on various naturally occurring plants that have a growth inhibiting effect on dandruff bacteria have been applied to the skin and scalp.

For example, folk medicinal herbs and herbal herbalists are attracting attention because they are known to have anti-dandruff and itching effects, and extracts obtained from plants that are traditionally known for their use are preferred for use on hair. It is included in conditioners, jumps, hair creams, hair tonics, etc.

However, many of the extracts created by combining these herbal medicine extracts are extremely effective and have been obtained through incorrect extraction methods that do not suit the purpose and are based on the traditional effects of ancient times. There are many cases where extracts with low levels of efficacy or parts that are completely ineffective are used, and many people say that these questions need to be substantiated with specific re-evaluation tests. ing.

In other words, depending on the extraction method, some of these extracts may have no effect at all, and may even be effective against dandruff bacteria.
On the contrary, there are some that exhibit a proliferative effect, and in order to answer these questions, the inventors of the present invention have evaluated the growth inhibition ability against PO in order to find evidence of their effectiveness. Ta.

The evaluation method using this PO is, for example, Hyakugan (Reference location:
According to the report, it was disclosed by Cosmetic Journal, Vol. 22, No. 3, 1988) et al.

Known plant extracts from the inside of the neck, Japanese cabbage, stonewort,
Extracts of Kujin, Chamomile, etc. are known to have a growth inhibiting effect on PO.

``Problem to be solved by the inventionJ'' External skin preparations and cosmetics are now containing various plant extracts that are believed to be effective in preventing dandruff in Chinese medicine and folk medicine. However, as mentioned above, some of these include supported data (effectiveness effect).
In some cases, extracts that are completely ineffective are often used, relying on ancient history without knowing what they are.

Therefore, the present inventors took this opportunity to introduce herbal medicines that have traditionally been used for the skin, scalp, hair, etc., as well as herbal medicines that have been taken in the hope of having other effects. We have conducted research on the theme of searching for and evaluating extracts that are randomly selected and are expected to have a preventive effect against dandruff.

In other words, by screening for accurate plant-derived extracts that inhibit PO growth, we apply cosmetics (cosmetics) in the form of external applications and rubs for the skin, scalp, and hair that are expected to have the effect of preventing dandruff and itching. With the aim of expanding its use, various plants were randomly transported to collect valuable P.
I was involved in the discovery and development of the O growth inhibiting component.

As a result, it was confirmed that the component obtained from bamboo and extracted using the specified solvent had an excellent PO growth inhibiting effect, and based on this, the present invention was successfully completed.

"Structure of the Invention" The present invention uses bamboo as an organic solvent, benzene, chloroform, ether, ethyl acetate, n-butanol,
One or more of acetone, ethanol, and metatsuru,
Preferably, it consists of an external preparation for the skin, scalp, and hair containing a PO growth-inhibiting component that has been soaked in and extracted with chloroform, ethyl acetate, acetone, or methanol.

"Means for Solving the Problems"<a) Preparation of suspension of Pityrosborum ovale The test bacterial species, Pityrosborum ovale (I FO0656),
Cultivate on potato dextrose agar medium containing 5% Nikkor TMGO-5 (manufactured by Nikko Chemical Co., Ltd.), remove 3 platinum loops, and place in 5 m I2 of physiological saline containing 0.7% Twin 80. After suspending in the same manner, 6
Measure the absorbance at 60 nm, and the absorbance is O, I
This suspension prepared with the above physiological saline was diluted 100 times with the above physiological saline so that ABs was obtained.
Pityrosvorum oberle suspension (P, 0 liquid) was prepared.

<b> Test method Add 0.1 mQ of dimethyl sulfoside (DMS○) containing the sample dissolved at each concentration and 0.5 mI2 of the above physiological saline to a sterilized test tube, and add the above P, O liquid 0.
Add 1 mff and mix (mix well), add 3 ml of soft agar, spread on potato dextrose agar medium (diameter 90 mm) containing 5% Nikkor TMGO-5, and after culturing at 37°C for 4 days, calculate the number of viable colonies. It was made into a number.

In addition, the control is one in which P and O liquids are not added.
As a sample, a mixture of the extract of Extraction Example I or 2 and glycerin at a ratio of 40:60 was used. or,
A reprinted 50% zinc pyrithione liquid mixture was used as a comparison sample (concentration is expressed as zinc pyrithione).

<c) Results Table 1 shows the results of the growth inhibition effect on PO.

The specimen containing the extract component of the present invention was 1000100.
At each concentration of 10 (μg/plate), the results were almost the same as the comparative sample zinc pyrithione.

However, this comparison sample had a concentration of 1000. loo, jO (μg/
The sample containing the extract component of the present invention was prepared with glycerin, and the sample containing the extract component of the present invention was 40%
Since the concentration is that of bamboo extract, it can be seen that the inhibitory effect on PO growth is 1 stronger than that of zinc pyrithione. The number of colonies in the control was 114.

According to the present invention, the bamboo extract serves as a PO growth inhibiting component.
The effect can be obtained by adding a small amount into the prescription, and it is suitable for hair,
Formulated in external skin preparations and cosmetics in various dosage forms such as scalp shampoos, conditioners, hair tonics, hair creams, hair ticks, and hair pomades, as well as skin lotions, creams, and emulsions. It can be used as

(Estimated amount of compounding) All of the extract and PO growth inhibiting components according to the present invention can be used as a compounding agent for preventing dandruff and itching. The usual amount is 0.61 to 0.5% in the prescription.
Depending on the extract, some effects can be expected by containing about 0.01 to 0.05% in the formulation.

In addition, the PO growth inhibiting ingredient made of bamboo extract according to the present invention can be used in all kinds of cosmetics, from solution-type products to creams, milky lotions, foundations, lipsticks, shampoos, conditioners, etc. for skin, scalp, and other products. It can be incorporated into the formulation of products for hair and the like.

For specific formulations, for example, see the following publications:
Prescription examples of creams and the like are shown for various uses, and the preparation can be made according to their manufacturing methods.

(Location of references for prescriptions) Science of fragrances and cosmetics: Back 1) Osamu et al. / October 5, 1980: Published by Koyo Shoten (Manufacturing/Extraction Example 1) Chloroform log for I kg of crushed bamboo.

After leaving the solution at room temperature for three days and nights, filter and collect the extract.

Next, this extract is concentrated to remove the solvent, and then dissolved in a small amount of ethanol to obtain an extract containing a PO growth-inhibiting component.

(Production/Extraction Example 2) Add 10Q of ethyl acetate to IKg of crushed bamboo,
After standing for three days and nights at room temperature, filter and separate the extract.

Next, this extract is concentrated to remove the solvent, and then dissolved in a small amount of ethanol to obtain an extract containing a PO growth-inhibiting component.

(Production/Extraction Example 3) Add 10I2 of acetone to Ikg of crushed bamboo,
After standing for three days and nights at room temperature, filter and separate the extract.

Next, this extract is concentrated to remove the solvent, and then dissolved in a small amount of ethanol to obtain an extract containing a PO growth-inhibiting component.

(Production/Extraction Example 4) Add methanol IO℃ to Ikg of crushed bamboo,
After standing for three days and nights at room temperature, filter and separate the extract.

Next, this extract is concentrated to remove the solvent, and then dissolved in a small amount of ethanol to obtain an extract containing a PO growth-inhibiting component.

"Confirmation of anti-dandruff and anti-itch effect"<a> Test method In the test, first, in the formulation of the hair shampoo shown in the following table (Table 2), the products obtained in the above production/extraction example were In addition, we prepared hair shampoos containing an extract containing PO growth-inhibiting ingredients and those without additives, and used these shampoos on selected subjects (20 people), including those who were prone to dandruff, and those with dandruff and itching. We compared and evaluated the effects after using the product for about two weeks.

The results were summarized as shown in the following tables (Tables 3 and 4).

That is, the numbers shown in Tables 3 and 4 are the results of the responses received regarding the effects of using each hair shampoo, expressed by the number of people.

<b> Results As shown in Table 3, it is estimated that the bare shampoo containing the extract: PO growth inhibiting ingredient according to the present invention is clearly effective in suppressing dandruff, even when compared to additive-free hair shampoo. It was done.

Furthermore, as shown in Table 4, it was estimated that the hair shampoo containing the extract of the present invention: PO growth-inhibiting component had a suppressing and alleviating effect on itching compared to the hair shampoo containing no additives.

"Table 2" Prescription of hair shampoo "Table 3" Preventing dandruff effect (number of respondents) Tables 3 and 4 show the PO growth inhibiting ingredients in hair shampoo from the above production/extraction examples. The effects of use when added were shown, and all of them were recognized to be effective.

"Effects of the Invention" The present invention is based on the discovery and utilization of a growth-inhibiting component for PO based on crushed bamboo.

That is, the expected effects of using the extract obtained from bamboo according to the present invention in external preparations for the skin, scalp, hair, or cosmetics are as follows:
It can be summarized in

■ Helps prevent and treat dandruff and itching on the skin and scalp.

■ According to the PO growth inhibiting ingredient according to the present invention, surfactants, humectants, lower alcohols, thickeners, fragrances, antioxidants, chelates, etc. can be used as necessary in the formulation of cosmetics for skin or hair. Known and commonly used ingredients such as agents, pigments, and preservatives can be used in any combination, and there are no special contraindications to their combination.

(2) The PO growth-inhibiting ingredient according to the present invention can prevent not only dandruff and itching, but also seborrheic eczema on the head and hair loss, and has the effect of promoting blood flow in the peripheral blood vessels of the face and skin.

■ The PO growth-inhibiting ingredient according to the present invention can be used in small amounts and at the same time, in formulations containing various lipids.
It exerts an antioxidant effect on fats and oils. In other words, the feature of the PO growth inhibiting ingredient according to the present invention is that it has an antioxidant effect on sebum and oils, suppresses the production of lipid peroxides, acts as a stabilizer for products, and maintains beautiful skin (prevents skin aging). prevention).

Claims (1)

[Claims] (1) Using crushed bamboo as a starting material, benzene, chloroform, ether, ethyl acetate, n-butanol, acetone,
A preparation for the skin, scalp, and hair, characterized by containing a dandruff bacteria growth-inhibiting component extracted using one or more of organic solvents such as ethanol and methanol.