JPH062654B2 - Hair cosmetics - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION [Industrial field of use] The present invention relates to a hair cosmetic containing a loofah extract.
In particular, it relates to hair cosmetics for preventing dandruff.

[Conventional technology]

In general, dandruff is composed of secretions of the sebaceous glands, secretions of the sweat glands, exfoliated and detached substances of the cortical layer, and the like, and is usually caused by increased secretion of the sebaceous glands. In particular, it is said that the occurrence of dandruff is pathologically promoted when bacteria or yeast infect the skin. For this reason, hair cosmetics to which an antibacterial agent or a bactericidal agent is added have been conventionally used as cosmetics for preventing dandruff. However, some of the antibacterial agents and bactericides have a problem in safety to the human body in terms of skin irritation, and the cosmetics containing the antibacterial agents and bactericides are used for daily use of skin resident bacteria. It has been pointed out that it sometimes causes an unfavorable situation from the viewpoint of so-called ecology, such as breaking the delicate balance of. For example, zinc pyrithione (ZPT), which has been conventionally recognized as the most effective antidandruff drug, is also included in the category of antibacterial agents, and it is preferable to avoid using it in large amounts as much as possible. It is considered.

Therefore, it has been widely demanded to prevent the occurrence of dandruff without using such an antibacterial agent or a bactericide, and in the industry, it has an effective antidandruff effect, and also has an antibacterial agent or a bactericide. There has been a quest for safe materials that can not stand.

So far, α-tocopherol / vitamin A has been used as a substance with anti-dandruff activity that is not based on antibacterial properties or bactericidal properties.
Acid ester (JP-A-51-73137) and vitamin E / nicotinic acid ester (German Patent Nos. 2301585 and 230)
1660 each specification) has been reported.

[Problems to be solved by the invention]

However, these vitamin E (that is, tocopherol) esters lack stability on the skin, and a long-lasting effect of suppressing dandruff cannot be expected. Further, since the above-mentioned vitamin E esters are insoluble in water, they have a drawback that an oily precipitate is formed depending on the cosmetic form. Further, in order to add the required amount of the substance, a large amount of surface active substance is required, and further, the substance has a drawback that the price is high.

As a result of investigating the antidandruff action of various substances to solve the above-mentioned conventional drawbacks, the present inventor has found that an extract of loofah of a Cucurbitaceae plant is extremely useful.

[Means for solving problems]

That is, the present invention comprises a loofah extract (however, consisting of loofah extract and zinc pyrithione, triclosan, trichlorocarbanilide, salicylic acid, sodium benzoate, hinokitiol, photosensitizer, halocarban, chlorhexidine gluconate, benzalkonium chloride). The present invention provides a hair cosmetic composition, especially a hair cosmetic composition for preventing dandruff, which comprises one or more compounds selected from the group).

"Luffa" that can be used in the present invention is Lufa Sindrika Roem (Luf) of the family Cucurbitaceae (Cucurbitaceae).
fa cylindrica Roem).

The loofah extract used in the present invention can be obtained from any part of the whole loofah plant. Ie loofah leaves,
It can be obtained from stems, roots, preferably fruits.

The loofah extract used in the present invention can be prepared by the following three-stage extraction operation.

In the first-stage extraction operation, the loofah raw material is used as it is or after it is cut into pieces, and then a water-soluble solvent such as water, or an alcohol such as methyl alcohol / ethyl alcohol, n.
-Propyl alcohol, isopropyl alcohol, n-
The extract obtained by digestion with butyl alcohol and these hydrous alcohols and filtration is concentrated. A reddish brown extract is thus obtained. This extract is
It is called the primary extract.

Next, the above-mentioned primary extract is suspended in water, and the soluble part is subjected to hydrophobic chromatography (eg silica gel ODS column) or molecular sieve (eg Amberlite XDA), and the adsorbing part is adsorbed to water. Then elute with methyl alcohol,
Concentrate the eluate under reduced pressure. In this way, a greenish brown powdery extract can be obtained. This extract is hereinafter referred to as the secondary extract.

Subsequently, the secondary extract is dissolved in methyl alcohol and subjected to hydrophobic chromatography or molecular sieve as described above. The extract obtained by concentrating the non-adsorbed portion is a slightly yellowish powder. It has a slight pungent odor, is easily soluble in methyl alcohol, ethyl alcohol, and water, but sparingly soluble in chloroform and acetone. This extract is hereinafter referred to as the third extract.

Although the chemical identity of the active ingredient having an antidandruff activity contained in each of the above luffa extracts is still unknown, the extraction step from the above-mentioned first extract to the third extract is performed. The higher the concentration, the higher the concentration of the active ingredient. Therefore, in order to obtain a significant antidandruff effect, it is necessary to use a relatively large amount of the primary extract, but a relatively small amount is sufficient for the tertiary extract. However, it is generally considered preferable to use the primary and secondary extracts because the manufacturing cost increases as the extraction steps are repeated.

The amount of the loofah extract of the present invention (as a solid) is 0.01 in the form of the primary extract, based on the weight of the total cosmetic composition.
% By weight or more, preferably 0.05% by weight or more, and in the form of the secondary extract 0.0025% by weight or more, preferably 0.013% by weight or more,
And, in the form of the third extract, it is 0.0008% by weight or more, preferably 0.004% by weight or more. The upper limit of the blending amount varies depending on the form of the cosmetic and can be arbitrarily blended, so it is not limited, but generally, the primary extract is about 10% by weight, the secondary extract is about 2.5% by weight, and 0.8 in the third extract
It is about% by weight.

The hair cosmetic composition of the present invention broadly refers to those applied to the hair or scalp, and includes, for example, hair tonic, hair liquid, scalp emulsion, hair cream, hair shampoo, hair rinse and the like.

The hair cosmetic composition of the present invention contains conventional ingredients such as oily ingredients (for example, squalane, petrolatum, lanolin), surfactants (for example, coconut oil fatty acid monoethanolamine, coconut oil fatty acid monoethanolamide, polyoxyethylene cetyl). Alcohol), moisturizers (eg glycerin), alcohols (eg ethyl alcohol, cetyl alcohol), thickeners, preservatives, UV absorbers, colorants,
Fragrances and the like can be added.

[Work]

The mechanism by which the hair cosmetic composition according to the present invention exhibits an effective antidandruff action is that the metabolic reaction of scalp tissue is appropriately regulated,
It is considered that the loofah extract inhibits the formation of dandruff on the scalp, which is a factor that causes dandruff.

〔Example〕

Hereinafter, the present invention will be described in more detail with reference to Examples.
This does not limit the technical scope of the present invention.

Example 1 This example illustrates a method for extracting a primary extract of loofah according to the present invention.

Luffa cylindrica Roe
Methyl alcohol 25 was added to 5 kg of the air-dried product of the fruit of m), and the mixture was heated under reflux for 1 hour. The extract was filtered and concentrated under reduced pressure to obtain 64 g of methyl alcohol extract.

Example 2 This example illustrates a method for extracting a secondary extract of loofah according to the present invention.

100 ml of water was added to and suspended in 64 g of the methyl alcohol extract of loofah fruit obtained in Example 1 above, and the soluble portion obtained by filtration was poured into a column packed with Amberlite XDA. Allowed to flow until colorless. Next, it was eluted with methyl alcohol 2. The eluates were combined and the methyl alcohol was distilled off under reduced pressure to obtain 11 g of a greenish brown residue.

Example 3 This example illustrates a method for extracting a tertiary extract.

11 g of the greenish brown powder extract of loofah obtained in Example 2 was dissolved in 400 ml of 35% methyl alcohol, and Servachrom X
The column was filled with AD. Column 2 was allowed to flow down with 35% methyl alcohol, and this solution was combined and the methyl alcohol and water were distilled off under reduced pressure to obtain 0.24 g of a slightly yellowish powder.

Example 4 This example illustrates the antidandruff effect of loofah extract according to the present invention.

To 75 g of ethanol, 0.2 g of the loofah extract (as a solid content) obtained in Example 2, 0.2 g of polyoxyethylene (40 mol) hydrogenated castor oil, 24.6 g of purified water, and a small amount of yellow 1 and a small amount of fragrance Were sequentially added to prepare a sample hair tonic. Similarly, hair tonics were prepared which differed only in that they did not contain the aforementioned loofah extract.

On the other hand, lauryl sulfate triethanolamine 18
A shampoo consisting of 1% by weight, 1% by weight carboxyvinyl polymer, 5% by weight glycerin, 1% by weight zinc pyrithione (ZPT), 10% by weight urea and 100% by weight purified water was prepared. Furthermore, a similar shampoo was prepared which was different from this shampoo only in that zinc pyrithione was not added.

As test subjects, eight males aged 22 to 48 having a relatively large amount of dandruff were selected. As a control period, first, for all 8 test subjects, the hair was shampooed with ZPT-free shampoo and the hair tonic with no loofah extract was added, and the dandruff accumulated in the two days after the shampooing and styling was collected. Twice a week for one month (total 8
The amount of protein in the collected dandruff was measured. Subsequently, 8 test subjects were divided into 2 groups (5 and 3). For 5 people in the first group, hair was shampooed with a ZPT-free shampoo and a hair tonic containing a loofah extract, and for 3 people in the second group, shampoo with ZPT and a hair tonic without a loofah extract were applied. Hair styling was performed. In each group, wash your hair
The operation of collecting the dandruff accumulated for 2 days after the hair styling was performed twice a week for 1 month (total 8 times), and the protein content in the dandruff was measured (sample period). The dandruff was collected by suctioning the head using a suction device. The reduction rate of dandruff in the sample period was calculated and the results are shown in Table 1.

From the above results, it was confirmed that the hair tonic containing the loofah extract exhibits almost the same or slightly superior anti-dandruff effect as compared with shampoo containing ZPT, which has been conventionally known as an anti-dandruff drug. .

Example 5 The antidandruff effect was examined by changing the blending amount of the loofah extract into the hair tonic. As a hair tonic sample, Table 2
6 types were prepared as shown in the composition column of. As test subjects, 30 men aged 22 to 48 were randomly selected, and 5 people were assigned to each sample for the test. Hair tonic is to be used once a day, and the average protein amount of dandruff accumulated in the control period (using the hair tonic without addition of the loofah extract) and the sample period (with the hair tonic containing the loofah extract) accumulated for 2 days after washing The average protein amount of dandruff accumulated in the subsequent 2 days was compared. When the reduction rate of dandruff is 10% or more, it is determined that there is an dandruff suppressing effect, and when the reduction rate of dandruff is less than 10%, it is determined that there is no dandruff suppressing effect, and the results are shown in Table 2.

In the case of the hair tonic containing 0.005% by weight of the primary extract of loofah of the present invention (Sample No. 1), the antidandruff effect was not observed in 4 out of 5 sample subjects, whereas In the case of Sample No. 3, which was increased 10 times, the results were reversed, and a remarkable antidandruff effect was observed in 4 out of 5 people. Loofah second
When the amount of the next extract is 0.1% by weight (Sample No. 4) or more,
A remarkable antidandruff effect was observed in all 5 test subjects.

Example 6 This example illustrates the antioxidant properties of a loofah extract according to the invention.

Put 1 g of ethyl linoleate into a 50 ml screw tube,
After adding 0.2 mg of each test substance described in Table 3 below and mixing well, the mixture was irradiated with ultraviolet rays for 3 hours to be air-oxidized, and then the amount of the generated peroxide of ethyl linoleate was adjusted to a high-pressure liquid. It was measured by chromatography (HPLC). Table 3 below
The amount of lipid peroxide shown in is the value when the test substance is not added (control) as 100%.

According to the research conducted by the present inventor, the occurrence of dandruff and the amount of lipid peroxide in dandruff have an extremely high correlation. That is,
It has been found that reducing the amount of lipid peroxide in the scalp can suppress the occurrence of dandruff. Therefore, an antioxidant that reduces the amount of lipid peroxide is originally useful as an antidandruff agent.

As is clear from Table 3 above, hemima saponin has no or almost no antioxidant power, whereas the first to third extracts of loofah according to the present invention have significant antioxidant power. To be From this, the antioxidative activity remarkably recognized in the primary and secondary extracts does not exist in the main components of the hemima extract, hemimasaponins E, F, and H, but these hemimasaponins are not present. It was found to be present in the residual fraction removed, ie the third extract.

Example 7 To 55 g of ethyl alcohol, 2 g of polyoxyethylene (8 mol) oleyl alcohol ether and an appropriate amount of perfume were added and dissolved at room temperature to obtain an alcohol phase. Separately, 5 g of glycerin and 0.2 g of the loofah extract obtained in Example 2 were added to 37.8 g of purified water and dissolved by heating. After cooling, a suitable amount of Yellow No. 1 was added, and an alcohol phase was added to the aqueous phase to solubilize it, to obtain a hair tonic having an antidandruff effect.

Example 8 20 g of polyoxypropylene butyl ether and 5 g of ethyl alcohol and an appropriate amount of perfume were dissolved at room temperature in an alcohol phase, and 0.2 g of the loofah extract obtained in Example 2 was added to purified water.
3 g was added and dissolved by heating, and after cooling, a portion to which an appropriate amount of Blue No. 2 was added was mixed to obtain a hair liquid having an antidandruff effect.

Example 9 Stearic acid 2 g, cetyl alcohol 1.5 g, petrolatum 3 g, liquid paraffin 12 g, polyoxyethylene (1
0 mol) 2 g of monooleic acid ester and an appropriate amount of perfume were mixed and heated to 80 ° C. to obtain an oil phase. Separately, 5 g of propylene glycol, 1 g of triethanolamine, 0.2 g of the loofah extract obtained in Example 2 and 71.3 g of purified water were heated to 80 ° C., and the above oil phase part was gradually added to this water phase part while stirring to emulsify. After cooling, a scalp emulsion having an antidandruff effect was obtained.

Example 10 Stearic acid 2 g, stearyl alcohol 7 g, lanolin 2 g, squalane 5 g, octyldodecanol 6 g,
3 g of polyoxyethylene (10 mol) cetyl ether,
2 g of glyceryl monostearate and an appropriate amount of fragrance were added, and the mixture was heated to 80 ° C. to obtain an oil phase. Separately, 5 g of propylene glycol, 1 g of the loofah extract obtained in Example 2 and 67 g of purified water were gradually added to the aqueous phase heated to 80 ° C. while stirring, emulsifying and cooling to have an antidandruff effect. I got a hair cream.

Example 11 Triethanolamine 1 lauryl sulfate was added to 79.5 g of purified water.
5 g, coconut oil fatty acid monoethanol amide 5 g, Example 2
0.5 g of the loofah extract obtained in 1., and appropriate amounts of Red 222 and perfume were added, and after heating and mixing, the mixture was cooled to obtain a hair shampoo having an antidandruff effect.

Example 12 3.5 g of polyethylene glycol 1500, 1 g of triethanolamine and 0.5 g of the loofah extract obtained in Example 2 were added to purified water 7
It was dissolved by heating in 4.5 g and kept at 70 ° C. Stearic acid 2.5
g, cetyl alcohol 1.5 g, petrolatum 5 g, squalane 10 g, and polyoxyethylene (10 mol) monooleate 2 g were dissolved by heating and added to the aqueous phase while maintaining the temperature at 70 ° C. After the preliminary emulsification, the emulsion was uniformly emulsified with a homomixer and gradually cooled to prepare a hair emulsion having an antidandruff effect.

〔The invention's effect〕

Unlike the conventional antibacterial or bactericide-containing cosmetics, the hair cosmetics of the present invention are safe to apply to the human head.
Further, unlike the conventional esters of vitamin E, it is water-soluble and therefore easy to use as a cosmetic. Moreover, it is cheaper than the above-mentioned esters. Further, it has excellent stability on the skin.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Takashi Ikeda 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Prefecture Shiseido Research Institute, Inc. (72) Inventor Keiichi Uehara 1050, Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Shiseido Research Institute Co., Ltd. (72) Inventor Junichi Koyama 1050 Shinba-cho, Kohoku-ku, Yokohama-shi, Kanagawa Stock Company Shiseido Research Institute (72) Inventor Izumi Horii, 1050 Niba-cho, Kohoku-ku, Yokohama-shi Kanagawa Co., Ltd. Shiseido Research Institute (72) Inventor Teruaki Hayashi 189-11 Oinogakiuchi, Higashitada, Kawanishi-shi, Hyogo Prefecture (72) Inventor Shigeru Ariji 2-6-11-1002 Terauchi, Toyonaka-shi, Osaka (56) Reference Japanese Patent Laid-Open No. 61- 263910 (JP, A)

Claims (1)

[Claims] 1. A luffa extract (however, a group consisting of luffa extract and zinc pyrithione, triclosan, trichlorocarbanilide, salicylic acid, sodium benzoate, hinokitiol, photosensitizer, halocarban, chlorhexidine gluconate, benzalkonium chloride). (Excluding a mixture of one or more selected from the above).