JP7539829B2 - Oral Composition - Google Patents

Description

The present invention relates to an oral composition.

Oral compositions such as dentifrice usually contain abrasives, surfactants, humectants, binders, etc., and nonionic surfactants are used as surfactants to foam and ensure cleaning properties. In addition to the physical cleaning sensation achieved by abrasives, etc., methods are known that add sodium bicarbonate and other salts to remove stickiness in the oral cavity and provide a refreshing feeling. However, sodium bicarbonate and other salts have an astringent taste, a particular unpleasant taste, irritation, etc., along with the refreshing feeling, which poses problems.

Patent Document 1 describes that by adding a specific amidobetaine type amphoteric surfactant to an oral composition containing a combination of sodium bicarbonate and sodium lauryl sulfate, it is possible to reduce mucosal irritation while maintaining a refreshing feeling. Patent Document 2 describes that by adding glycine, alanine, leucine, glutamic acid, and salts thereof to an oral composition containing bicarbonate, etc., the expression of astringent properties caused by sodium bicarbonate is suppressed. Patent Document 3 describes that by adding one or more waxes selected from lanolin and its derivatives, whale wax, carnauba wax, candelilla wax, and beeswax to an oral composition containing an astringent compound such as baking soda, it is possible to improve the astringent taste of sodium bicarbonate.

Japanese Patent Application Publication No. 11-49654 Patent No. 3922329 Japanese Patent Application Publication No. 11-21219

However, the technology of Patent Document 1 is insufficient for improving the astringent taste (astringent feeling). In addition, the technologies of Patent Documents 2 and 3 are also insufficient for suppressing the astringent taste, and there is room for improvement in terms of the duration of the astringent taste suppression effect. The astringent taste (astringent feeling) can lead to discomfort, especially for young people, and the development of a suppression method is expected.
An object of the present invention is to provide an oral composition which can eliminate stickiness in the oral cavity, provide a refreshing feeling, suppress astringent feeling, and maintain the effect of suppressing the astringent feeling.

That is, the present invention provides the following [1] to [8].
[1] An oral composition containing (A) one or more selected from the group consisting of carbonates, hydrogen carbonates, sulfates, and chlorides, and (B) one or more selected from the group consisting of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, ethyl-3-(p-menthane-3-carboxamide)acetate, and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide (excluding dentifrice compositions containing (A) sodium sulfate and (B) ethyl-3-(p-menthane-3-carboxamide)acetate).
[2] The oral composition according to [1], which satisfies at least one of the following:
The carbonate is at least one selected from the group consisting of sodium carbonate, potassium carbonate, and magnesium carbonate;
the hydrogen carbonate is at least one selected from the group consisting of sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, and magnesium hydrogen carbonate;
The sulfate is at least one selected from the group consisting of sodium sulfate, potassium sulfate, magnesium sulfate, aluminum potassium sulfate, aluminum sodium sulfate, and aluminum ammonium sulfate; and the chloride is at least one selected from the group consisting of sodium chloride, potassium chloride, and magnesium chloride.
[3] The oral composition according to [1] or [2], wherein the content of the (A) component is 0.1 to 10 mass%.
[4] The oral composition according to any one of [1] to [3], wherein the content of the (B) component is 0.00001 to 0.1 mass%.
[5] (C): The oral composition described in any one of [1] to [4], further containing a nonionic surfactant.
[6] The oral composition according to [5], wherein the component (C) comprises one or more members selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and polyglycerin fatty acid ester.
[7] The oral composition according to [5] or [6], wherein the content of component (E) is 0.1 to 1 mass %.
[8] The oral composition according to any one of [1] to [7], which is a dentifrice, a mouthwash, a spray, a topical agent, a patch, or an oral dissolving agent.

The present invention provides an oral composition that can eliminate stickiness in the oral cavity, provide a refreshing feeling, suppress astringent sensation, and maintain the effect of suppressing the astringent sensation.

The present invention will be described in detail below.
The oral composition of the present invention contains the following components (A) and (B), and preferably further contains component (C).

[Component (A)]
The component (A) is at least one selected from the group consisting of carbonates, hydrogen carbonates, sulfates, and chlorides. By containing the component (A), a refreshing feeling can be imparted to the oral cavity composition. When the component (B) is ethyl-3-(p-menthane-3-carboxamido)acetate, the component (A) is other than sodium sulfate, that is, at least one selected from the group consisting of carbonates, hydrogen carbonates, aluminum sulfate, and chlorides.

Examples of carbonates include sodium carbonate, potassium carbonate, and magnesium carbonate. Examples of hydrogen carbonates include sodium hydrogen carbonate, potassium hydrogen carbonate, calcium hydrogen carbonate, and magnesium hydrogen carbonate. Examples of sulfates include sodium sulfate, potassium sulfate, magnesium sulfate, aluminum sulfate, and alum, with aluminum sulfate and alum being preferred. Examples of alums include aluminum potassium sulfate, aluminum sodium sulfate, and aluminum ammonium sulfate chloride. Examples of alums include sodium chloride, potassium chloride, and magnesium chloride. Examples of alums include aluminum potassium sulfate, aluminum sodium sulfate, and aluminum ammonium sulfate. Of these, sodium hydrogen carbonate, sodium chloride, and aluminum potassium sulfate are preferred. The (A) component may be one type or a combination of two or more types.

The content of component (A) is usually 0.05% by mass or more, preferably 0.1% by mass or more, and more preferably 0.2% by mass or more, based on the entire oral composition (100% by mass). This provides a refreshing feeling. The upper limit is usually 20% by mass or less, preferably 10% by mass or less, and more preferably 5% by mass or less. This prevents the appearance of an astringent feeling. Therefore, the content of component (A) is usually 0.05 to 20% by mass, preferably 0.1 to 10% by mass, more preferably 0.2 to 10% by mass, and even more preferably 0.2 to 5% by mass.

[Component (B)]
Component (B) is one or more selected from the group consisting of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, ethyl-3-(p-menthane-3-carboxamide)acetate, and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide. By containing component (B), it is possible to impart to the oral composition a suppressed astringent feeling and to maintain the suppressed astringent feeling. In this specification, the term "astringent feeling" refers to the sensation of the gums tightening, and is distinguished from irritation (simple pain).

The (B) component may be one type or a combination of two or more types, but it is preferable that it contains at least N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide. This can provide a better effect of suppressing and sustaining the astringent sensation. It is even more preferable that it contains at least N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide. This can provide a better effect of suppressing and sustaining the astringent sensation, and also provide a better refreshing feeling.

The content of the (B) component is usually 0.000001% by mass or more, preferably 0.00001% by mass or more, more preferably 0.00005% by mass or more, based on the entire oral composition (100% by mass). This allows the effect of suppressing the astringent feeling and the effect of sustaining the suppression of the astringent feeling to be exerted. The upper limit is usually 0.5% by mass or less, more preferably 0.1% by mass or less, even more preferably 0.01% by mass or less, and even more preferably 0.005% by mass or less. This allows the occurrence of irritation in the oral cavity and the decrease in flavor expression to be suppressed. Therefore, the content of the (B) component is usually 0.000001 to 0.5% by mass, preferably 0.00001 to 0.1% by mass, more preferably 0.00001 to 0.01% by mass, and even more preferably 0.00005 to 0.005% by mass.

[Component (C)]
Component (C) is a nonionic surfactant. By including component (C), the oral cavity composition can be provided with an effect of suppressing astringent sensation.

Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 15 to 30 moles. The average number of moles of ethylene oxide added in polyoxyethylene hydrogenated castor oil is usually 20 to 100 moles, preferably 20 to 60 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40 moles. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14. As nonionic surfactants, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, and polyoxyethylene alkyl ether are preferred.

The content of component (C) is usually 0.01% by mass or more, preferably 0.1% by mass or more, and more preferably 0.3% by mass or more, based on the entire oral composition (100% by mass). This provides a good effect of suppressing the astringent feeling. The upper limit is usually 5% by mass or less, preferably 1% by mass or less, and more preferably 0.8% by mass or less. This prevents a decrease in the refreshing feeling and a decrease in flavor expression. Therefore, the content of component (C) is usually 0.01 to 5% by mass, preferably 0.1 to 1% by mass, more preferably 0.3 to 1% by mass, and even more preferably 0.3 to 0.8% by mass.

[Optional ingredients]
The oral composition of the present embodiment may contain optional components other than the components (A) to (C) already described, as long as the effects of the present invention are not impaired.

Optional ingredients include, for example, surfactants, sweeteners, fragrances, medicinal ingredients, oily ingredients, abrasives, preservatives, humectants, binders, pH adjusters, colorants (pigments), and solvents. Specific examples are described below.

- Abrasives -
The abrasive may be either inorganic or organic. Examples of inorganic abrasives include abrasive silica such as precipitated silica, aluminosilicate, zirconosilicate, crystalline zirconium silicate, and titanium-bonded silica; calcium phosphate compounds such as calcium diphosphate dihydrate or anhydrous, calcium monophosphate, calcium triphosphate, and calcium pyrophosphate; calcium carbonate abrasives such as calcium carbonate; calcium abrasives other than carbonate/phosphate such as calcium hydroxide and calcium sulfate; aluminum materials such as aluminum oxide, aluminum hydroxide, and alumina; silicic acid materials such as anhydrous silicic acid, zeolite, and zirconium silicate; magnesium materials such as magnesium carbonate and magnesium triphosphate; apatite materials such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; titanium materials such as titanium dioxide, titanium mica, and titanium oxide; and minerals such as bentonite. Examples of organic abrasives include polymethyl methacrylate and synthetic resin abrasives. Of these, silica-based abrasives are preferred.

The content of the abrasive is usually 70% by mass or less, preferably 50% by mass or less, and more preferably 8 to 50% by mass, based on the total oral composition (100% by mass).

-Surfactants-
Examples of the surfactant other than the component (C) include anionic surfactants, amphoteric surfactants, and cationic surfactants.

Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. The alkyl and acyl groups may be either linear or branched, and may be either saturated or unsaturated, and the number of carbon atoms is usually 10 to 20, preferably 12 to 18, and more preferably 12 to 14. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples of such salts include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Examples of alkyl sulfates include lauryl sulfate (sodium lauryl sulfate) and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamate salts such as lauroyl glutamate, myristoyl glutamate, and palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acylalanine salt; and acyl aspartate salts such as lauroyl aspartate. Examples of acyltaurine salts include lauroyl methyl taurine salt, N-methyl-N-acyltaurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonate salts include α-olefin sulfonate salts having 12 to 18 carbon atoms, such as tetradecene sulfonate salt. Other examples of anionic surfactants include hydrogenated sodium coconut fatty acid monoglyceride monosulfate and sodium lauryl sulfoacetate.

From the standpoint of foaming and foam quality, it is preferable for the anionic surfactant to contain a sulfonic acid group, and alkyl sulfates and α-olefin sulfonates are more preferable.

Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyl dimethylamino acetate betaine (e.g., lauryl dimethylamino acetate betaine) and fatty acid amidopropyl dimethylamino acetate betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; and alkyl betaines such as lauryl dimethylamino acetate betaine. Examples of cationic surfactants include alkyl ammonium salts and alkyl benzyl ammonium salts.

Examples of cationic surfactants include alkyl ammonium salts and alkyl benzyl ammonium salts.

The content of the surfactant (other than component (C)) is preferably 0.1 to 3 mass%, more preferably 0.6 to 2.5 mass%, and even more preferably 1 to 2.5 mass%, relative to the total oral composition (100 mass%).

- Wetting agent -
By including a wetting agent in the composition, the feeling during use can be further improved.

As the humectant, sugar alcohols and polyhydric alcohols other than sugar alcohols are preferred. Examples of sugar alcohols include sugar alcohols such as sorbitol, erythritol, maltitol, lactitol, xylitol, and reduced starch saccharification products; glycerin; and polyhydric alcohols such as ethylene glycol, propylene glycol, dipropylene glycol, butylene glycol, and polyethylene glycol. Examples of polyethylene glycols include polyethylene glycols having an average molecular weight of 150 to 6000, and preferably polyethylene glycols having an average molecular weight of 190 to 630. Specific examples include PEG200, PEG300, PEG400, and PEG600. The content of the humectant is usually 40% by mass or less, and preferably 1 to 30% by mass, based on the entire oral composition (100% by mass). The average molecular weight is the average molecular weight described in the Quasi-Drug Raw Materials Standards 2006.

-Medicinal ingredients-
Examples of medicinal ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Liteque enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; ε-aminocaproic acid, allantoin, tranexamic acid, glycyrrhizinate (e.g., dipotassium glycyrrhizinate), glycyrrhetinic acid, glycyrrhetinate (e.g., stearyl glycyrrhetinate), aluminum chlorhydroxyl allantoin, azulene, dihydrochole, and the like. Anti-inflammatory agents such as sterols; metal salts such as zinc, copper salts, and tin salts; tartar prevention agents such as condensed phosphates and ethanehydroxydiphosphonates; blood flow promoters such as vitamin E (e.g., tocopherol acetate); dentin hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride; coating agents such as hydroxyethylcellulose dimethyl diallyl ammonium chloride; astringents other than component (A) such as vitamin C (e.g., ascorbic acid or its salts) and lysozyme chloride; water-soluble copper compounds such as copper chlorophyll and copper gluconate; tartar prevention agents, amino acids such as alanine, glycine, and proline, plant extracts such as thyme, Scutellaria baicalensis, clove, and witch hazel; callopeptide and polyvinylpyrrolidone can be mentioned. The medicinal components may be used alone or in combination of two or more. The content of the medicinal components can be appropriately set to an effective amount according to a conventional method.

-Fragrance-
The composition contains a fragrance, which can improve the feeling of use. Examples of the fragrance include natural essential oils such as peppermint oil, spearmint oil, Japanese peppermint oil, anise oil, cassia oil, eucalyptus oil, wintergreen oil, mastic oil, neroli oil (orange flower oil), lemongrass oil, jasmine oil, rose oil, iris oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, laurel oil, chamomile oil, caraway oil, basil oil, marjoram oil, lemon oil, orange oil, lime oil, yuzu oil, nutmeg oil, lavender oil, paracles oil, vanilla oil, cinnamon oil, pimento oil, cassia leaf oil, perilla oil, and wintergreen oil; menthol, carvone, cinnamic aldehyde, anethole, 1,8-cineole, methyl salicylate, eugenol, thymol, Examples of the flavoring include flavoring components contained in the above-mentioned natural essential oils, such as linalool, limonene, menthone, menthyl acetate, citral, decanal, camphor, borneol, pinene, spilanthol, n-decyl alcohol, citronellol, α-terpineol, citronellyl acetate, cineole, ethyl linalool, vanillin, etc.; flavoring components, such as ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methylphenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, etc.; and various blended flavors, such as mint, fruit, herb, etc., which are obtained by combining several flavoring components and natural essential oils. As the flavoring, the above-mentioned flavorings may be used alone or in combination of two or more.

-Sweetener-
The composition contains a sweetener, which can improve the feeling of use. Examples of sweeteners include saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, glycyrrhizin, thaumatin, aspartyl phenylalanine methyl ester, etc. As the sweetener, the above-mentioned sweeteners may be used alone or in combination of two or more.

-Oily ingredients-
Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms, such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms, such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

- Preservatives -
The composition contains a preservative, thereby ensuring the preservative power of the preparation. Examples of the preservative include paraoxybenzoic acid esters (e.g., methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate), sodium benzoate, etc. The preservative may be used alone or in combination of two or more.

- Binding agent -
By including any binder in the composition, the viscosity can be optimized, and the shape retention and the feeling of use can be further improved. Examples of the binder include any suitable organic binder known in the art, such as polysaccharides, cellulose-based binders (e.g., carboxymethylcellulose (CMC), hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, cationic cellulose, etc.), other polysaccharide-based thickeners (e.g., xanthan gum, guar gum, gellan gum, tragacanth gum, karaya gum, arabic gum, locust bean gum, carrageenan, sodium alginate), and synthetic water-soluble polymers (e.g., sodium polyacrylate, carboxyvinyl polymer, polyvinylpyrrolidone, polyvinyl alcohol, propylene glycol alginate). Furthermore, inorganic binders such as thickening silica and aluminum silicate can also be blended. The content of any organic binder is preferably 0 to 3% by mass, more preferably 0.1 to 2% by mass, based on the entire oral composition (100% by mass). The content of the inorganic binder is preferably 0 to 10% by mass, and more preferably 1 to 8% by mass.

- pH adjuster -
The composition contains a pH adjuster, thereby ensuring the pH stability of the formulation. Examples of pH adjusters include organic acids such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, or their salts (sodium citrate), inorganic acids such as phosphoric acid (orthophosphoric acid), or their salts (e.g., potassium salts, sodium salts, and ammonium salts), and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate.

The content of the pH adjuster is usually an amount such that the pH of the oral composition after addition is 5 to 9, preferably 6 to 8.5.

In this specification, the pH value usually refers to the value measured at 25°C and 3 minutes after the start of measurement. The pH value can be measured, for example, using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

- Coloring agent -
Examples of colorants include natural colorants such as safflower red colorant, gardenia yellow colorant, gardenia blue colorant, perilla colorant, red koji colorant, red cabbage colorant, carrot colorant, hibiscus colorant, cacao colorant, spirulina blue colorant, tamarind colorant, etc., legal colorants such as Red No. 2, Red No. 3, Red No. 104, Red No. 105, Red No. 106, Red No. 227, Yellow No. 4, Yellow No. 5, Green No. 3, Blue No. 1, etc., riboflavin, sodium copper chlorophyte, titanium dioxide, etc. When the oral composition contains a colorant, the content thereof is preferably 0.00001 to 3% by mass based on the total oral composition.

-solvent-
Examples of the solvent include water (purified water), ethanol, etc., and water is preferred. The solvent may be used alone or in combination of two or more.

-Other optional ingredients-
Examples of optional components other than those mentioned above include polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these optional components can be appropriately set within a range that does not impair the effects of the present invention.

[Formulation and Use of Oral Composition]
The oral composition of the present invention can be prepared as an oral preparation such as a dentifrice, mouthwash, spray, liniment, patch, or oral dissolving agent. The dosage form of the oral composition can be appropriately selected according to the mode of use and is not particularly limited. For example, the dosage form may be a paste or liquid, and in the case of a dentifrice, it can be prepared as a toothpaste, liquid dentifrice, liquid dentifrice, or lubricant dentifrice.

[Method of producing the composition]
The method of producing the oral composition is not particularly limited, and it can be prepared by a conventional method according to the dosage form. For example, when it is used as a toothpaste, it can be a method of preparing a component that dissolves in a solvent, mixing the other insoluble components, and degassing (e.g., reducing pressure, etc.) as necessary. The obtained toothpaste can be put into a container to make a product. The shape and material of the container are not particularly limited, and a container used for a conventional toothpaste composition can be used, for example, a container such as a laminated tube made of plastic such as polyethylene, polypropylene, polyethylene terephthalate, nylon, etc.

The present invention will be specifically described below with reference to examples and comparative examples. The present invention is not limited to the following examples. Note that the values in the following tables represent mass % unless otherwise specified.

[Components used in the Examples and Comparative Examples]
-Component (A)-
Sodium hydrogen carbonate: Sodium bicarbonate (manufactured by Asahi Glass Co., Ltd.)
Sodium sulfate: anhydrous sodium sulfate (Tomita Pharmaceutical Co., Ltd.)
Sodium chloride: (Specially selected salt, Nihonkaisui Co., Ltd.)
Aluminum potassium sulfate: (manufactured by Taimei Chemical Industry Co., Ltd.)

-Component (B)-
N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide: (Coolact (registered trademark) 370, manufactured by Takasago International Corporation)
Ethyl-3-(p-menthane-3-carboxamide) acetate: (WS-5, manufactured by Toyotama Fragrance Co., Ltd.)
N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide: (Evercool® 190, Givaudan)
N-ethyl-p-menthane-3-carboxamide: (WS-3, manufactured by Symrise Japan Co., Ltd.)

-Component (C)-
Polyoxyethylene (20) hydrogenated castor oil: (manufactured by Nippon Emulsion Co., Ltd.)

Components other than components (A) to (C) Abrasive silica: Tixosil (registered trademark) 73 (manufactured by Solvay)
Sodium fluoride: (Stella Chemifa Corporation)
Sodium lauryl sulfate: (manufactured by BASF)
Sorbitol solution (70%): (Mitsubishi Corporation Life Sciences Co., Ltd.)
Propylene glycol: (manufactured by ADEKA)
Viscosifying silica: Carplex (registered trademark) #67 (manufactured by DSL Japan Co., Ltd.)
Sodium saccharin: (manufactured by Aisan Chemical Industry Co., Ltd.)
For ingredients other than those mentioned above, raw materials conforming to the Standards for Quasi-Drug Raw Materials 2006 were used.

Examples 1 to 28 and Comparative Examples 1 to 8
Using the above ingredients as raw materials, toothpastes having the compositions shown in Tables 1 to 5 below were prepared according to the preparation method described below.

[Method of preparing toothpaste]
The raw materials shown in Tables 1 to 5 were mixed in a conventional manner to obtain toothpastes, which were then packed in laminated tubes.

[Evaluation method]
The toothpaste was evaluated by four panelists for its usability. They placed 1 g of the sample toothpaste on a toothbrush (Clinica Advantage Toothbrush, 4-row compact regular type, manufactured by Lion Corporation) and brushed their teeth for 3 minutes. The refreshing feeling, the effect of suppressing astringent feeling, and the duration of the effect of suppressing astringent feeling were evaluated according to the following rating scale. The scores of the four panelists were averaged and evaluated according to the following rating scale.

<Refreshing feeling>
Regarding the refreshing feeling, the refreshing feeling was evaluated based on the presence or absence of stickiness in the oral cavity after rinsing the oral cavity with water after brushing the teeth.
Rating criteria: 4 points: felt very refreshed 3 points: felt refreshed 2 points: felt not very refreshed 1 point: felt no refreshment Evaluation criteria: ◎: average score of 3.5 to 4.0 points ○: average score of 3.0 to less than 3.5 points △: average score of 2.0 to less than 3.0 points ×: average score of less than 2.0 points

<Suppression of astringent sensation>
The effect of suppressing the astringent sensation was evaluated based on the strength of the astringent sensation immediately after rinsing the mouth with water after brushing the teeth.
Evaluation criteria 4 points: No astringency was felt 3 points: Almost no astringency was felt 2 points: Astringency was felt 1 point: A very strong astringency was felt Evaluation criteria ☆: Average score of 3.8 to 4.0 points ◎: Average score of 3.5 to less than 3.8 points ○: Average score of 3.0 to less than 3.5 points △: Average score of 2.0 to less than 3.0 points ×: Average score of less than 2.0 points

<Sustained effect of suppressing astringent sensation>
The duration of the astringent sensation suppressing effect was evaluated based on the time during which no astringent sensation was felt after rinsing the mouth with water after brushing the teeth.
Evaluation criteria: 4 points: 25 minutes or more (no irritation felt)
3 points: 15 minutes or more but less than 25 minutes 2 points: 5 minutes or more but less than 15 minutes 1 point: Less than 5 minutes Evaluation criteria ◎: Average score of 3.5 points or more but less than 4.0 points ○: Average score of 3.0 points or more but less than 3.5 points △: Average score of 2.0 points or more but less than 3.0 points ×: Average score of less than 2.0 points

Comparative Example 1, which contained only the (B) component, was rated low for refreshing feeling, and Comparative Examples 2 to 6, which contained only the (A) component, were rated low for suppressing astringent feeling on the oral mucosa (Table 5). In contrast, Examples 1 to 28, which were combinations of the (A) and (B) components, were rated good for refreshing feeling and suppressing effect on astringent feeling, and the suppressing effect on astringent feeling was also sustained (Tables 1 to 4). Among them, Examples 24 to 28, which further contained the (C) component, had a better suppressing effect on astringent feeling (Table 4).
In Comparative Example 8, which contained only the control component (B), the rating of refreshing feeling was low, similar to Comparative Example 1, which contained only the component (B). However, in Comparative Example 7, which was combined with the component (A), the effect of suppressing the astringent feeling on the oral mucosa was low, similar to Comparative Examples 2 to 6, which were combinations of the components (A) and (B), and no effect of adding the control component (B) was found (Table 5).
These results show that the oral composition of the present invention can provide a refreshing feeling by eliminating stickiness in the oral cavity, suppress astringent sensation, and sustain the effect of suppressing the astringent sensation.

Claims (7)

An oral composition containing (A) one or more members selected from the group consisting of sodium bicarbonate, sodium chloride, magnesium sulfate, and aluminum potassium sulfate, and (B) one or more members selected from the group consisting of N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, ethyl-3-(p-menthane-3-carboxamide)acetate, and N-(2-(2-pyridinyl)ethyl)-2-isopropyl-5-methylcyclohexanecarboxamide (however, dentifrice compositions containing (A) sodium sulfate and (B) ethyl-3-(p-menthane-3-carboxamide)acetate are excluded). The oral composition according to claim 1 , wherein the content of component (A) is 0.1 to 10 mass%. The oral composition according to claim 1 or 2 , wherein the content of component (B) is 0.00001 to 0.1 mass%. The oral composition according to any one of claims 1 to 3 , further comprising (C): a nonionic surfactant. 5. The oral composition according to claim 4 , wherein component (C) comprises one or more members selected from the group consisting of polyoxyethylene hydrogenated castor oil, polyoxyethylene alkyl ether, and polyglycerin fatty acid ester. The oral composition according to claim 4 or 5 , wherein the content of the component ( C ) is 0.1 to 1 mass%. The oral composition according to any one of claims 1 to 6 , which is in the form of a dentifrice, a mouthwash, a spray, a liniment, a patch, or an oral dissolving agent.