JP7347416B2 - Oral composition - Google Patents

Description

TECHNICAL FIELD The present invention relates to an oral composition suitable for suppressing bad breath, which contains a copper-containing compound and provides an excellent sense of effectiveness due to the firmness of the gums.

It has long been known that copper-containing compounds, such as water-soluble copper salts, have been used as chemical deodorants for substances that cause halitosis, and can be used in combination with other halitosis control measures or in conjunction with saliva secretion stimulants. Efforts have been made to improve the effect (Patent Document 1: Japanese Patent No. 3,661,741), but the effect that the user actually feels is not necessarily fully satisfactory. In addition, oral preparations containing copper salts have an unpleasant metallic taste derived from copper and a unique astringent feeling accompanied by irritation, which may affect the feeling of use of the oral preparation.

In response to the above problem, the applicant proposed that benzyl alcohol and xylitol or erythritol suppress the metallic taste and astringent feeling caused by copper and improve palatability (Patent Document 2: International Publication No. 2016/93279 ). In addition, by preparing an oral composition containing a betaine-type amphoteric surfactant and a specific sugar alcohol such as xylitol in combination with a copper compound, and applying it in a gel form, it is possible to remove the It was proposed that suppression of bitter taste and mucosal irritation and imparting a sufficient astringent feeling to the gums are compatible (Patent Document 3: International Publication No. 2010/113688).
In addition, as techniques for masking the unpleasant taste of copper salts, there is Utilization of gin and citrus oil (Patent Document 5: JP-A-01-153622) and combination of allantoin and nonionic surfactant (Patent Document 6: JP-A-2010-189358) are effective. Proposed.

By the way, in recent years, oral preparations with various medicinal effects have been provided, but in addition to the actual medicinal effects, it is important to provide users with a sense of effectiveness that allows them to feel the effects satisfactorily, which will lead to continued use. This is important because further improvement in effectiveness can be expected. Bad breath, for which copper-containing compounds are effective, is often caused by periodontal problems such as gums, and the fact that the effect is felt on the gums is likely to be recognized by users as having a halitosis control effect, giving them a high sense of satisfaction. You can expect to give. In Patent Document 3 mentioned above, the astringent feeling of copper is utilized to improve the effect of imparting an astringent feeling to the gums, but there is still room for improvement in terms of the effective feeling on the gums.

Patent No. 3661741 International Publication No. 2016/93279 International Publication No. 2010/113688 Japanese Patent Application Publication No. 2003-137755 Japanese Patent Application Publication No. 01-153622 Japanese Patent Application Publication No. 2010-189358

The present invention was made in view of the above circumstances, and an object of the present invention is to provide an oral composition that contains a copper-containing compound and provides an excellent feeling of effectiveness due to the firmness of the gums.

As a result of intensive studies to achieve the above object, the present inventor found that when (B) menthyl glutarate is added to an oral composition containing (A) a copper-containing compound, the The present invention has been made based on the discovery that the unpleasant metallic taste and astringent feeling of the mouth can be suppressed, and that the gums feel firmer, and that this firmer feeling can satisfactorily impart an excellent sense of effectiveness, especially the sense of effectiveness in suppressing bad breath. reached.

In oral compositions containing copper-containing compounds, suppression of the astringent sensation by the copper-containing compounds tended to simultaneously result in a decrease in the effective sensation on the gums. However, in the present invention, when component (A) and component (B) are used together, the two interact specifically, suppressing the astringent feeling caused by component (A), and even if the astringent feeling is suppressed, the effective effect on the gums remains. A high sense of firmness was obtained. That is, this feeling of firmness of the gums made the patient feel that the health of the gums was improved and bad breath was suppressed. As a result, the effective feeling of the component (A), especially the effective feeling of suppressing bad breath, can be imparted by the feeling of elasticity in the gums, and the user can feel a high sense of satisfaction through the sensation felt in the gums, where the user can easily recognize the effective feeling. Ta.
In this case, when component (A) is omitted and only component (B) is blended, the firmness of the gums is hardly felt (Comparative Example 3 described later), and when component (B) is omitted, (A) ) ingredients are blended, and furthermore, the warming agents spilanthol and capsaicin, and the L-menthol derivatives 3-L-menthoxypropane-1,2-diol and N, which are known as cooling agents and refreshing agents, etc. -Even if ethyl-p-menthane-3-carboxamide is blended, the firmness of the gums will hardly be felt (Comparative Examples 2, 4 to 7, described later), and the astringent feeling may not be suppressed in some cases. It was less effective. On the other hand, the oral composition containing components (A) and (B) of the present invention (examples described below) gives a sufficient sense of elasticity to the gums, and almost no metallic taste and astringent feeling. There was no such thing.

Therefore, the present invention provides the following oral composition.
[1]
An oral composition containing (A) a copper-containing compound and (B) menthyl glutarate.
[2]
(A) For the oral cavity according to [1], wherein the copper-containing compound is one or more water-soluble copper salts selected from copper gluconate, copper sulfate, copper chloride, copper chlorophyllin sodium, and copper acetate. Composition.
[3]
(B) The oral composition according to [1] or [2], wherein the menthyl glutarate is a mixture of monomenthyl glutarate and dimenthyl glutarate.
[4]
The oral composition according to [3], wherein the mixing ratio of monomenthyl glutarate and dimenthyl glutarate is 1:9 to 9:1 as a mass ratio.
[5]
(A)/(B), which indicates the ratio between the content of component (A) as copper ions and the content of component (B), is 0.0001 to 20 as a mass ratio [1] to [4] The oral composition according to any one of the above.
[6]
The oral composition according to any one of [1] to [5], which contains component (A) in an amount of 0.0001 to 0.1% by mass as copper ions, and component (B) in an amount of 0.0001 to 2% by mass.
[7]
The oral composition according to any one of [1] to [6], further comprising a surfactant.
[8]
The oral cavity composition according to any one of [1] to [7], which is a dentifrice composition.
[9]
The oral composition according to any one of [1] to [8], which is used for suppressing bad breath.

According to the present invention, it is possible to provide an oral composition that contains a copper-containing compound, gives an excellent feeling of effectiveness due to the firmness of the gums, and has a good taste and other usability. This oral composition has a high effect of suppressing bad breath due to the copper-containing compound, and can be suitably used for suppressing bad breath.

The present invention will be explained in more detail below. The oral composition of the present invention contains (A) a copper-containing compound and (B) menthyl glutarate.

(A) As the copper-containing compound, a water-soluble copper salt having a halitosis suppressing effect and usable for oral use can be used. Examples include copper gluconate, copper sulfate, copper chloride, sodium copper chlorophyllin, copper acetate, etc. Among them, copper gluconate and sodium copper chlorophyllin are preferred, and copper gluconate is more preferred.

(A) The compounding amount of the copper-containing compound is preferably 0.0001 to 0.1% (mass%, hereinafter the same) of the entire composition as copper ions, more preferably 0.001 to 0.1%, Particularly preferred is 0.005 to 0.1%. When it is 0.0001% or more, a sufficient effect of imparting firmness to the gums can be obtained. If it is 0.1% or less, metallic taste and astringency can be sufficiently suppressed.

(B) Menthyl glutarate is known as a cooling agent and a refreshing sensation imparting agent, but in the present invention, when used in combination with the (A) component, it acts as a gum firmness imparting agent; It has the effect of suppressing the unpleasant metallic taste and astringent feeling caused by
Examples of menthyl glutarate include monomenthyl glutarate and dimenthyl glutarate. Although these may be used alone, a mixture of monomenthyl glutarate and dimenthyl glutarate is more preferable, especially from the viewpoint of imparting firmness to the gums.

Here, when mixing monomenthyl glutarate and dimenthyl glutarate, the mixing ratio of both (monomenthyl glutarate: dimenthyl glutarate) is preferably 1:9 to 9:1 as a mass ratio, more preferably is from 1:1 to 9:1, more preferably from 3:2 to 3:1. When the mixing ratio is within the above range, a sufficient feeling of firmness can be imparted to the gums, and the effective feeling is excellent.

The amount of menthyl glutarate (B) blended is preferably 0.0001 to 2%, more preferably 0.001 to 2%, and even more preferably 0.005 to 1% of the total composition. When it is 0.0001% or more, it is possible to sufficiently give a feeling of elasticity to the gums. When it is 2% or less, irritation caused by the component (B) can be suppressed, and the firmness of the gums can be sufficiently maintained.

In the present invention, (A)/(B), which indicates the ratio between the content of component (A) (content as copper ions) and the content of component (B), is 0.0001 to 20 as a mass ratio. It is preferably from 0.001 to 10, even more preferably from 0.01 to 3. Within this range, the effect of imparting firmness to the gums is sufficiently excellent, and metallic taste and astringent feeling are sufficiently suppressed.

The oral composition of the present invention can be prepared as a dentifrice composition, for example, toothpaste, liquid toothpaste, moisturized toothpaste, etc., and toothpaste is particularly preferred. Further, in addition to the above-mentioned components, other known components may be blended as necessary within a range that does not impair the effects of the present invention, water may be added to these blended components, and the composition can be prepared in a conventional manner. Specifically, optional components that can be blended include abrasives, thickeners, binders, surfactants, sweeteners, preservatives, fragrances other than component (B), pH adjusters, and components other than component (A). Examples include medicinal ingredients.

Abrasives include silica-based abrasives such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-binding silica; dibasic calcium phosphate dihydrate salt or anhydrate, monobasic calcium phosphate, tribasic calcium phosphate, calcium pyrophosphate, etc. Calcium phosphate abrasives; Calcium carbonate abrasives such as calcium carbonate, calcium hydroxide, aluminum hydroxide, tertiary magnesium phosphate, magnesium carbonate, calcium sulfate, bentonite, hydroxyapatite, and one or more of these abrasives; Two or more types can be combined. Among these, silica-based abrasives containing silicate as a main component, such as precipitated silica, aluminosilicate, zirconosilicate, and titanium-binding silica, are particularly preferred from the standpoint of imparting firmness to the gums. The amount of these abrasives added is preferably 8 to 70% of the total composition.

Examples of thickeners include polyhydric alcohols such as glycerin and propylene glycol, and sugar alcohols such as sorbitol and xylit. The amount of the thickening agent blended is preferably 5 to 50%, particularly 20 to 45% of the total composition.

As the binder, an organic binder or an inorganic binder may be used. Examples of organic binders include gums such as xanthan gum, carrageenan, and cellulose derivatives such as sodium carboxymethyl cellulose and methyl cellulose. Examples of the inorganic binder include thickening silica and aluminum silicate. These can be used alone or in combination of two or more. The amount of the binder added is preferably 1.4 to 10%, particularly 1.4 to 8% of the total composition.

Examples of the surfactant include anionic surfactants, nonionic surfactants, and amphoteric surfactants, with anionic surfactants being particularly preferred.
Examples of anionic surfactants include alkyl sulfates such as sodium lauryl sulfate, α-olefin sulfonates, N-acyl taurates, acyl sarcosine salts, and acylamino acid salts. Among these, anionic surfactants containing sulfonic acid groups with good foaming and foam quality are preferred from the viewpoint of imparting firmness to the gums, and alkyl sulfates and α-olefin sulfonates are more preferred. Examples of the salts include sodium salts, potassium salts, ammonium salts, and the like, with sodium salts being particularly preferred.
The alkyl sulfate preferably has an alkyl group having 12 to 14 carbon atoms, and examples thereof include sodium lauryl sulfate and sodium myristoyl sulfate.
The α-olefin sulfonate is preferably an alkali metal salt such as sodium or potassium of α-olefin sulfonic acid having 14 to 16 carbon atoms, and particularly an α-olefin sulfonate having 14 carbon atoms, especially the sodium salt (common name; Sodium tetradecene sulfonate) is good.
These surfactants may be used alone or in combination of two or more.
The amount of the surfactant, particularly the anionic surfactant, is preferably 0.6 to 2.5%, particularly 1 to 2.5%, based on the total composition.

Examples of sweeteners include sodium saccharin.
Examples of the preservative include paraoxybenzoic acid ester, sodium benzoate, and the like.

The fragrance includes known fragrances such as menthol, anethole, carvone, eugenol, limonene, n-decyl alcohol, citronellol, α-terepineol, citronellyl acetate, cineole, linalool, ethyllinalool, vanillin, thymol, spearmint oil, peppermint oil, Examples include lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, pimento oil, cinnamon leaf oil, perilla oil, wintergreen oil, clove oil, and eucalyptus oil.

Examples of the pH adjuster include inorganic compounds such as hydrochloric acid, sodium hydroxide, potassium hydroxide, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

Optional medicinal ingredients include, for example, enzymes such as dextranase; anti-inflammatory agents such as tranexamic acid, epsilon aminocaproic acid, and aluminum chlorohydroxyallantoin; cell activators such as vitamins; isopropylmethylphenol, cetylpyridinium chloride, and benzalcochloride. Anti-tartar agents such as zeolite; blood circulation promoters such as vitamin E. The amount of medicinal ingredients to be blended can be set to an effective amount within a range that does not impede the effects of the present invention.

EXAMPLES Hereinafter, the present invention will be specifically explained by showing Examples, Comparative Examples, and Prescription Examples, but the present invention is not limited to the following Examples. In addition, in the following examples, % indicates mass % unless otherwise specified.

[Example, Comparative Example]
Using menthyl glutarate 1 to 5 and fragrance A shown in Tables 1 and 2 below, dentifrice compositions (toothpaste) of each example were prepared and evaluated by the following method.

Evaluation method Toothpastes with the compositions shown in Tables 5 to 7 below were prepared in a conventional manner, and 10 subjects (specialist panel) brushed their teeth in the usual manner using these toothpastes, and evaluated whether or not there was a feeling of firmness in the gums after brushing. The metallic taste (absence of metallic taste) and astringent feeling (absence of astringent feeling) derived from copper salts in toothpaste were sensory evaluated and judged according to the evaluation criteria shown in Tables 3 and 4. The results are also listed in Tables 5-7.

As can be seen from the results in Table 5, when component (A) or component (B) was combined alone, the firmness of the gums was hardly felt (Comparative Examples 2 and 3), and spilanthol, capsaicin, L - Even when any of the menthol derivatives was used in combination with component (A), when component (B) was not mixed, the gums hardly felt firm (Comparative Examples 4 to 7). On the other hand, as can be seen from the results in Tables 6 and 7, the toothpastes (Examples 1 to 11) containing the components (A) and (B) of the present invention had sufficient elasticity on the gums. It was also confirmed that the metallic taste and astringent feeling were suppressed, giving a good feeling of use. The toothpastes of these Examples had an excellent effect of suppressing bad breath, and had an excellent sense of effectiveness, giving a high sense of satisfaction.

Prescription examples are shown below. A toothpaste according to the formulation example was prepared and evaluated in the same manner using the same raw materials as above, and it was found that the toothpaste had a high firmness on the gums and was sufficiently felt, and the metallic taste and astringent feeling during use were suppressed. It felt good to use.

[Prescription example 1] (toothpaste)
(A) Copper gluconate 0.1
(Copper ion amount 0.014)
(B) Monomenthyl glutarate 0.0065
(B) Dimenthyl glutarate 0.0035
3-L-menthoxypropane-1,2-diol 0.05
Silicic anhydride 20
glycerin 35
Xanthan gum 0.6
carrageenan 0.2
Sodium lauryl sulfate 1.5
Saccharin sodium 0.1
Fragrance A 1
Purified water remainder
Total 100%
Mass ratio of (A) (copper ion amount)/(B): 1.4

[Prescription example 2] (toothpaste)
(A) Copper gluconate 0.1
(Copper ion amount 0.014)
(B) Monomenthyl glutarate 0.0065
(B) Dimenthyl glutarate 0.0035
N-ethyl-p-menthane-3-carboxamide 0.05
Silicic anhydride 20
glycerin 35
Xanthan gum 0.6
carrageenan 0.2
Sodium lauryl sulfate 1.5
Saccharin sodium 0.1
Fragrance A 1
Purified water remainder
Total 100%
Mass ratio of (A) (copper ion amount)/(B): 1.4

[Prescription example 3] (toothpaste)
(A) Copper gluconate 0.1
(Copper ion amount 0.014)
(B) Monomenthyl glutarate 0.0065
(B) Dimenthyl glutarate 0.0035
N-ethyl-p-menthane-3-carboxamide 0.05
Isopropylmethylphenol 0.1
Sodium monofluorophosphate 1.1
Silicic anhydride 20
glycerin 35
Propylene glycol 4
Carboxymethyl cellulose sodium 1.2
Xanthan gum 0.3
Sodium lauroylmethyltaurine 1.0
Saccharin sodium 0.1
Fragrance A 1
Purified water remainder
Total 100%
Mass ratio of (A) (copper ion amount)/(B): 1.4

[Prescription example 4] (toothpaste)
(A) Copper gluconate 0.1
(Copper ion amount 0.014)
(B) Monomenthyl glutarate 0.0065
(B) Dimenthyl glutarate 0.0035
3-L-menthoxypropane-1,2-diol 0.05
Isopropylmethylphenol 0.1
Sodium monofluorophosphate 1.1
Tocopherol acetate 0.1
Silicic anhydride 15
Sorbitol 20
Propylene glycol 4
Xanthan gum 1.0
Sodium lauryl sulfate 1.0
Saccharin sodium 0.1
Fragrance A 1
Purified water remainder
Total 100%
Mass ratio of (A) (copper ion amount)/(B): 1.4

[Prescription example 5] (toothpaste)
(A) Copper gluconate 0.1
(Copper ion amount 0.014)
(B) Monomenthyl glutarate 0.0065
(B) Dimenthyl glutarate 0.0035
N-ethyl-p-menthane-3-carboxamide 0.05
Isopropylmethylphenol 0.1
Sodium monofluorophosphate 1.1
Silicic anhydride 20
Sorbitol 30
Xanthan gum 0.6
carrageenan 0.2
Sodium tetradecene sulfonate 0.5
Saccharin sodium 0.1
Fragrance A 1
Purified water remainder
Total 100%
Mass ratio of (A) (copper ion amount)/(B): 1.4

Claims (8)

(A) 0.0001 to 0.1% by mass of a copper-containing compound as copper ions , and (B) a mixing ratio of monomenthyl glutarate and dimenthyl glutarate of 1:1 to 9:1 by mass. 0.0001 to 2% by mass of a mixture of
An oral cavity composition in which (A)/(B), which represents the ratio between the content of component (A) as copper ions and the content of component (B), is 0.0001 to 20 as a mass ratio. The composition for oral cavity according to claim 1, wherein (A) the copper-containing compound is one or more water-soluble copper salts selected from copper gluconate, copper sulfate, copper chloride, sodium copper chlorophyllin, and copper acetate. thing. The oral composition according to claim 1 or 2 , wherein the mixing ratio of monomenthyl glutarate and dimenthyl glutarate is 3 : 2 to 3 : 1 in terms of mass ratio. Any one of claims 1 to 3 , wherein (A)/(B), which indicates the ratio between the content of component (A) as copper ions and the content of component (B), is 0.001 to 10 as a mass ratio. Oral composition according to item 1. The composition for oral cavity according to any one of claims 1 to 4, which contains component (A) in an amount of 0.001 to 0.1% by mass as copper ions and component (B) in an amount of 0.001 to 2% by mass. The oral composition according to any one of claims 1 to 5 , further comprising a surfactant. The oral composition according to any one of claims 1 to 6 , which is a dentifrice composition. The oral cavity composition according to any one of claims 1 to 7 , which is used for suppressing bad breath.