JP7523346B2 - Oral Composition - Google Patents

Description

The present invention relates to an oral composition.

Oral compositions such as dentifrice contain abrasives such as calcium phosphate, calcium carbonate, and abrasive silica to provide the basic function of cleaning dirt attached to the surfaces of the oral cavity, such as the teeth. The amount of abrasive is usually set according to the cleaning power of each component used as an abrasive. For example, abrasive silica has a relatively high cleaning power, so it is generally added to dentifrice compositions at a rate of 10 to 25% by mass, whereas calcium phosphate and calcium carbonate have relatively low cleaning power and are often added at a rate of 30 to 60% by mass. In general commercially available dentifrices, the cleaning power is adjusted to a certain range regardless of the abrasive used, so there is no significant difference. On the other hand, because there is no difference in cleaning power, the amount of abrasive varies by 2 to 3 times depending on the dentifrice, which leads to differences in the feeling of use on the teeth, oral cavity, and tongue when brushing the teeth.

In addition, oral compositions such as dentifrice may contain water-soluble polymers as binders to maintain shape retention and make it easier to apply to a toothbrush. Water-soluble polymers are involved in the rheological properties of oral compositions, and in the case of dentifrice, they also affect the feel of the toothbrush when used.

Patent Document 1 discloses that a dentifrice composition containing calcium carbonate, silica granules, and two types of sodium carboxymethylcellulose with different viscosities has a high cleaning power, an excellent brushing sensation, a good usability without a foreign body sensation, and excellent moldability and formulation appearance. Patent Document 2 discloses that a dentifrice composition containing heavy calcium carbonate, water-insoluble inorganic granules, and two types of water-soluble polymeric substances has an appropriate abrasive power and an excellent usability due to the synergistic effect of the brushing sensation of the granules and excellent dispersibility in the dentifrice. Patent Document 3 discloses that a toothpaste composition containing a combination of a binder of crosslinked polyacrylic acid or its salt and a carboxymethylcellulose salt in a specified ratio, and a specified amount of water, containing an abrasive such as calcium carbonate, has excellent shape retention on a toothbrush and dispersibility in the oral cavity.

International Publication No. 2012/090571 International Publication No. 2006/003989 Patent No. 3959639

However, when an inorganic powder abrasive and a water-soluble polymer are used in an oral composition, the dispersibility of the inorganic powder in the oral cavity decreases depending on the amount of these ingredients, causing a sticky feeling on the oral mucosa and tongue, resulting in a poor usability.

The present invention has been made in consideration of the above circumstances, and aims to provide an oral composition that contains an inorganic powder and a water-soluble polymer, which has shape retention and brushability, as well as improved thickness derived from the powder and a good usability.

That is, the present invention provides the following [1] to [7].
[1] A composition for an oral cavity comprising (A) an inorganic powder, (B) a water-soluble polymer, and (C) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide, the content of component (B) being 0.5 to 1.5% by mass.
[2] The oral composition described in [1], wherein the inorganic powder is an inorganic calcium salt.
[3] The oral composition according to [1] or [2], wherein the water-soluble polymer is one or more selected from the group consisting of carrageenan, sodium alginate, xanthan gum, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, sodium polyacrylate, carboxyvinyl polymer, acrylic acid-maleic anhydride copolymer, polyvinyl alcohol and polyvinylpyrrolidone.
[4] The oral composition according to any one of [1] to [3], wherein the water-soluble polymer is (B1) one or more selected from the group consisting of carrageenan, sodium alginate, xanthan gum, and sodium carboxymethylcellulose, and (B2) one or more selected from the group consisting of sodium polyacrylate, carboxyvinyl polymer, and acrylic acid-maleic anhydride copolymer.
[5] The oral composition according to any one of [1] to [4], wherein the content of the (A) component is 10 to 60 mass%.
[6] The oral composition according to any one of [1] to [5], wherein the content of the (C) component is 0.00001 to 0.01 mass%.
[7] The oral composition according to any one of [1] to [6], which is a dentifrice composition.

The present invention provides an oral composition that suppresses the sticky feeling caused by powder, has a good usability, and can provide a good cleaning feel and shape retention.

The present invention will be described in detail below.

The oral composition of the present invention contains the following components (A), (B), and (C). In this specification, the content of each component is based on the amount of each component charged when the composition is produced.

[Component (A)]
The component (A) is an inorganic powder that acts as an abrasive. By including the component (A), the brushing sensation can be improved.

Examples of inorganic powders contained in component (A) include inorganic calcium salts (e.g., calcium phosphates such as dibasic calcium phosphate dihydrate or anhydrate, monobasic calcium phosphate, calcium pyrophosphate, insoluble calcium metaphosphate, tribasic calcium phosphate, tetrabasic calcium phosphate, and octabasic calcium phosphate; calcium carbonate (light and heavy); calcium hydroxide, calcium sulfate, and calcium oxide); silica-based powders (anhydrous silicic acid, zeolite, precipitated silica, aluminosilicate, zirconosilicate, titanium-bonded silica, silica gel, and the like); inorganic aluminum salts such as aluminum hydroxide and alumina; inorganic magnesium salts such as magnesium carbonate and tribasic magnesium phosphate; apatite-based powders such as hydroxyapatite, fluoroapatite, and calcium-deficient apatite; bentonite; and titanium dioxide. Inorganic calcium salts are preferred, and calcium carbonate and calcium phosphate are more preferred. Component (A) may be one type of inorganic powder alone, or two or more types may be combined.

The content of the inorganic powder contained in the (A) component is usually 5% by mass or more, preferably 10% by mass or more, more preferably 20% by mass or more, and even more preferably 30% by mass or more, based on the entire oral composition (100% by mass). This allows for a good brushing sensation. The upper limit is usually 65% by mass or less, preferably 60% by mass or less, based on the entire oral composition (100% by mass). This allows for the suppression and improvement of the thick feeling during use. In other words, the content of the inorganic powder contained in the (A) component is usually 5 to 65% by mass, preferably 10 to 60% by mass, based on the entire oral composition (100% by mass). In this specification, the term "thick feeling" refers to the unpleasant feeling (so-called heaviness) caused by the powder-containing foam sticking to the oral mucosa and the tip of the tongue. When an oral composition contains a calcium-based abrasive such as an inorganic calcium salt, the content is generally greater than the content of other abrasives, which can easily cause a thick feeling, but in the present invention, even if the content of component (A) is high (for example, even if it is 30% by mass or more), the thick feeling can be suppressed.

[Component (B)]
The component (B) is a water-soluble polymer. By including the component (B), the shape retention can be improved.

Examples of the water-soluble polymer contained in component (B) include organic binders such as cellulose-based binders (e.g., sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, methylcellulose, and cationic cellulose), carrageenan, xanthan gum, guar gum, tragacanth gum, karaya gum, gum arabic, locust bean gum, sodium alginate, montmorillonite, sodium polyacrylate, polyvinylpyrrolidone, polyvinyl alcohol, carboxyvinyl polymer, acrylic acid-maleic anhydride copolymer, and propylene glycol alginate. Among these, it is preferable to use one or more selected from the group consisting of carrageenan, sodium alginate, xanthan gum, sodium carboxymethylcellulose, methylcellulose, hydroxyethylcellulose, sodium polyacrylate, carboxyvinyl polymer, acrylic acid-maleic anhydride copolymer, polyvinyl alcohol, and polyvinylpyrrolidone, and carrageenan, sodium carboxymethylcellulose, sodium polyacrylate, and carboxyvinyl polymer are more preferable.

The component (B) may be a single water-soluble polymer, or a combination of two or more types. When two or more types are combined, the water-soluble polymer contained in the component (B) is preferably a combination of (B1) a polysaccharide and (B2) a water-soluble polymer containing a unit derived from a (meth)acrylic acid monomer in its structure. Examples of the components (B1) and (B2) include the following.
(B1) One or more selected from the group consisting of carrageenan, sodium alginate, xanthan gum, and sodium carboxymethylcellulose.
(B2) One or more members selected from the group consisting of sodium polyacrylate, carboxyvinyl polymers, and acrylic acid-maleic anhydride copolymers.

The lower limit of the content of component (B) is usually 0.5% by mass or more, preferably 1% by mass or more, based on the entire oral composition (100% by mass). This allows the shape retention of the oral composition to be maintained. The upper limit is usually 1.5% by mass or less, preferably 1.3% by mass or less, based on the entire oral composition (100% by mass). This allows the thick feeling during use to be suppressed and improved. In other words, the content of component (B) is usually 0.5 to 1.5% by mass, preferably 1 to 1.3% by mass, based on the entire oral composition (100% by mass).

In the case of a combination of the (B1) component and the (B2) component, the content of the (B1) component is preferably 0.1 to 1.4% by mass, and more preferably 0.2 to 1.3% by mass. The content of the water-soluble polymer contained in the (B2) component is preferably 0.1 to 1.4% by mass, and more preferably 0.2 to 1.3% by mass (however, the amount of the (B) component is 0.5 to 1.5% by mass). Furthermore, the (B1)/(B2) (content ratio) is preferably 0.5 to 10, more preferably 1 to 9.5, and even more preferably 1.5 to 9. This maintains the shape retention of the oral composition and reduces and improves the thick feeling during use.

[Component (C)]
The component (C) is N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide.

By including component (C), the sticky feeling during use can be reduced and improved.

The lower limit of the content of component (C) is usually 0.00001% by mass or more, preferably 0.00005% by mass or more, based on the entire oral composition (100% by mass). This makes it possible to suppress and improve the thick feeling during use. The upper limit is usually 0.01% by mass or less, preferably 0.005% by mass or less, based on the entire oral composition (100% by mass). This makes it possible to suppress a decrease in the feeling of use without causing a strong irritating feeling in the oral cavity. In other words, the content of component (C) is usually 0.00001 to 0.01% by mass, preferably 0.00005 to 0.005% by mass, based on the entire oral composition (100% by mass).

[Optional ingredients]
The oral composition of the present embodiment may contain optional components other than the components (A) to (C) already described, as long as the effects of the present invention are not impaired.

Optional components include, for example, abrasives other than component (A), fragrances other than component (C), thickeners, surfactants, moisturizers, and, if necessary, sweeteners, solvents, oily components, colorants, preservatives, storage stabilizers, pH adjusters, and active ingredients. Specific examples are described below.

- Abrasives other than component (A) -
Examples of the abrasive other than the component (A) include organic abrasives such as polymethyl methacrylate and synthetic resin-based abrasives.

The content of abrasives other than component (A) is preferably adjusted so that the total amount of the inorganic powder contained in component (A) and abrasives other than component (A) is 10 to 60% by mass relative to the entire oral composition (100% by mass).

-Fragrances other than component (C)-
Examples of fragrances other than component (C) include peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, and jasmine oil. Natural fragrances such as mint oil, iris concrete, absolute peppermint, absolute rose, orange flower, and fragrances obtained by processing these natural fragrances (front distillation, back distillation, fractional distillation, liquid-liquid extraction, essences, powdered fragrances, etc.); menthol, carvone, anethole, cineole, methyl salicylate, cinnamic aldehyde, eugenol, 3-1-menthoxypropane-1,2-diol, thymol, linalool, linalyl acetate Examples of the flavorings include single flavors such as ethyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthan-3-carboxamide, pinene, octylacetaldehyde, citral, pulegone, carbeto acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethyl methylphenyl glycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol, butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, methyl lactate, and ethyl thioacetate; and compound flavors such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor, butter flavor, milk flavor, fruit mix flavor, and tropical fruit flavor. Also exemplified are cooling agents other than component (C), such as N-ethyl-p-menthane-3-carboxamide, menthyl lactate, menthyl monosuccinate, isopulegol, menthone glycerol ketal, N-(4-cyanomethylphenyl)-p-menthanecarboxamide, 3-1-menthoxypropane-1,2-diol, 5-methyl-2-propan-2-yl-N-(2-pyridin-2-ylethyl)cyclohexane-1-carboxamide, 3-(p-menthane-3carboxamide)ethyl acetate, and 2-isopropyl-N,2,3-trimethylbutyramide.Other known flavoring materials used in oral compositions may also be used.

The content of flavorings other than component (C) is preferably 0.000001 to 1% by mass based on the entire oral composition (100% by mass). In the case of flavorings using these flavorings, the content is preferably 0.1 to 2.0% by mass based on the entire oral composition (100% by mass).

Examples of thickening agents include polyhydric alcohols such as glycerin, sorbitol, ethylene glycol, propylene glycol, polyethylene glycol, polypropylene glycol, xylitol, maltitol, and lactol.

The content of the thickening agent is usually 1 to 45% by mass, preferably 2 to 40% by mass, based on the total oral composition (100% by mass).

-Surfactants-
Examples of the surfactant include anionic surfactants, nonionic surfactants, and amphoteric surfactants.

Examples of anionic surfactants include alkyl sulfates, acyl amino acid salts, acyltaurine salts, α-olefin sulfonates, hydrogenated coconut fatty acid monoglyceride monosulfates, and lauryl sulfoacetates. When the surfactant has an acyl group, the acyl group may be either linear or branched, saturated or unsaturated, and the number of carbon atoms is usually 10 to 20. The salt may be selected from pharmacologically acceptable salts. Examples of pharmacologically acceptable salts include base addition salts and amino acid salts. Specific examples include inorganic base salts such as sodium salts, potassium salts, calcium salts, magnesium salts, and ammonium salts; organic base salts such as triethylammonium salts, triethanolammonium salts, pyridinium salts, and diisopropylammonium salts; and basic amino acid salts such as arginine salts. Among these, inorganic base salts are preferred, alkali metal salts (e.g., sodium salts, potassium salts) or ammonium salts are more preferred, and sodium salts are even more preferred.

Examples of alkyl sulfates include lauryl sulfate and myristoyl sulfate. Examples of acylamino acid salts include acyl sarcosine salts such as lauroyl sarcosine salt and myristoyl sarcosine salt; acyl glutamate salts such as lauroyl glutamate, myristoyl glutamate, palmitoyl glutamate; acyl glycine salts such as N-lauroyl-N-methyl glycine salt and cocoyl glycine salt; acyl alanine salts such as N-lauroyl-β-alanine salt, N-myristyl-β-alanine salt, N-cocoyl-β-alanine salt, N-lauroyl-N-methyl-β-alanine salt, N-myristoyl-N-methyl-β-alanine salt, and N-methyl-N-acylalanine salt; and acyl aspartate salts such as lauroyl aspartate. Examples of acyltaurine salts include lauroyl methyl taurine salt, N-methyl-N-acyltaurine salt, and N-cocoyl methyl taurine salt. Examples of α-olefin sulfonate salts include α-olefin sulfonate salts having 12 to 14 carbon atoms, such as tetradecene sulfonate salt. Other examples of anionic surfactants include hydrogenated sodium coconut fatty acid monoglyceride monosulfate and sodium lauryl sulfoacetate.

Examples of nonionic surfactants include polyoxyethylene alkyl ethers, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters (e.g., polyoxyethylene sorbitan monostearate), alkylolamides, polyoxyethylene fatty acid esters, polyoxyethylene alkenyl ethers, glycerin fatty acid esters, sucrose fatty acid esters (e.g., maltose fatty acid esters), sugar alcohol fatty acid esters (e.g., maltitol fatty acid esters, lactitol fatty acid esters), fatty acid diethanolamides (e.g., lauric acid mono- or diethanolamide), polyoxyethylene polyoxypropylene copolymers, and polyoxyethylene polyoxypropylene fatty acid esters. The number of carbon atoms in the alkyl chain of the polyoxyethylene alkyl ether is usually 14 to 18, and the average number of moles of ethylene oxide added is usually 15 to 30 moles. The average number of moles of ethylene oxide added in polyoxyethylene hydrogenated castor oil is usually 20 to 100 moles, preferably 60 to 100 moles. The number of carbon atoms in the fatty acid of the sorbitan fatty acid ester is usually 12 to 18. The number of carbon atoms in the fatty acid of the polyoxyethylene sorbitan fatty acid ester is usually 16 to 18, and the average number of moles of ethylene oxide added is usually 10 to 40 moles. The number of carbon atoms in the alkyl chain of the alkylolamide is usually 12 to 14.

Examples of amphoteric surfactants include betaine-type amphoteric surfactants such as alkyl dimethylamino acetate betaine (e.g., lauryl dimethylamino acetate betaine) and fatty acid amidopropyl dimethylamino acetate betaine (e.g., cocamidopropyl betaine); imidazoline-type amphoteric surfactants such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethyl ethylenediamine salts (e.g., N-coconut fatty acid acyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine), coconut fatty acid imidazolinium betaine, and 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine; and alkyl betaines such as lauryl dimethylamino acetate betaine.

The surfactant content is preferably 0.1 to 4% by mass based on the total oral composition (100% by mass).

-Sweetener-
Examples of sweeteners include xylitol, erythritol, maltitol, saccharin, saccharin sodium, aspartame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidin dihydrochalcone, perillartine, thaumatin, aspartyl phenylalanine methyl ester, etc. As the sweetener, the above-exemplified sweeteners may be used alone or in combination of two or more.

-solvent-
The solvent may be, for example, water (purified water). The amount of the solvent is usually 1 to 90% by mass, preferably 15 to 80% by mass, and more preferably 20 to 60% by mass, based on the total amount of the composition.

-Oily ingredients-
Examples of oily components include hydrocarbons such as squalane, liquid paraffin, petrolatum, and microcrystalline wax; higher alcohols (e.g., alcohols having 8 to 22 carbon atoms, such as lauryl alcohol, cetyl alcohol, cetostearyl alcohol, oleyl alcohol, and isostearyl alcohol); higher fatty acids (e.g., fatty acids having 8 to 22 carbon atoms, such as lauric acid, myristic acid, oleic acid, and isostearic acid), vegetable oils such as olive oil, castor oil, and coconut oil; and fatty acid esters such as isopropyl myristate.

- Coloring agent -
Examples of colorants include Red No. 2, Red No. 3, Red No. 225, Red No. 226, Yellow No. 4, Yellow No. 5, Yellow No. 205, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 204, Green No. 3, titanium mica, and titanium oxide.

-Preservative-
Examples of preservatives include paraoxybenzoic acid esters (eg, methyl paraoxybenzoate, ethyl paraoxybenzoate, butyl paraoxybenzoate) and sodium benzoate.

- pH adjuster -
Examples of pH adjusters include organic acids or salts thereof such as phthalic acid, citric acid, succinic acid, acetic acid, fumaric acid, malic acid, and lactic acid, inorganic acids or salts thereof (e.g., potassium salts, sodium salts, and ammonium salts) such as phosphoric acid (orthophosphoric acid), and hydroxides such as sodium hydroxide and potassium hydroxide. Examples of inorganic acid salts include disodium hydrogen phosphate and sodium dihydrogen phosphate.

The content of the pH adjuster is usually an amount such that the pH of the oral composition after addition is 6 to 10, preferably 7 to 9.

In this specification, the pH value usually refers to the value measured at 25°C and 3 minutes after the start of measurement. The pH value can be measured, for example, using a pH meter (model number Hm-30S) manufactured by Toa Denpa Kogyo Co., Ltd.

-Active ingredient-
Examples of active ingredients include bactericidal or antibacterial agents such as cetylpyridinium chloride, benzalkonium chloride, benzethonium chloride, isopropylmethylphenol, zinc gluconate, zinc citrate, triclosan, thymol, hinokitiol, and lysozyme chloride; enzymes such as dextranase, mutanase, amylase, protease, and Liteque Enzyme; fluorides such as sodium fluoride, sodium monofluorophosphate, and tin fluoride; ε-aminocaproic acid, allantoin, tranexamic acid, allantoin chlorohydroxyaluminum, glycyrrhizinate (e.g., dipotassium glycyrrhizinate), glycyrrhetinic acid, glycyrrhetinic acid derivatives (e.g., stearyl glycyrrhetinate), azulene, dihydrocobalamin, and the like. Examples of the medicinal ingredients include anti-inflammatory agents such as esterol, metal salts such as zinc salts, copper salts, and tin salts, condensed phosphates, ethanehydroxydiphosphonates, and other tartar prevention agents, blood flow promoters such as vitamin E (e.g., tocopherol acetate), hypersensitivity inhibitors such as potassium nitrate, aluminum lactate, and strontium chloride, coating agents such as hydroxyethylcellulose dimethyl diallyl ammonium chloride, astringents such as vitamin C (e.g., ascorbic acid or its salts), lysozyme chloride, and sodium chloride, water-soluble copper compounds such as copper chlorophyll and copper gluconate, tartar prevention agents, amino acids such as alanine, glycine, and proline, plant extracts such as thyme, Scutellaria baicalensis, clove, and witch hazel, callopeptide, and polyvinylpyrrolidone. The medicinal ingredients may be used alone or in combination of two or more. The content of the medicinal ingredients can be appropriately set to an effective amount according to the usual method.

-Other optional ingredients-
Examples of optional components other than those mentioned above include polyisobutylene, polybutadiene, urethane, silicone, and natural rubber. The content of these optional components can be appropriately set within a range that does not impair the effects of the present invention.

[Formulation and Use of Oral Composition]
The oral composition of the present invention can be made into any suitable dosage form by any suitable method according to conventional methods.The dosage form can be, for example, liquid (solution, emulsion, suspension, syrup, etc.), semi-solid (gel, cream, paste, etc.), solid (tablet, particulate agent, capsule, film agent, kneaded material, molten solid, waxy solid, elastic solid, soft capsule, etc.).The dosage form of the oral composition is preferably liquid or semi-solid.

The oral composition of the present invention can be widely used in oral applications. Examples of applications of the composition in a solid dosage form include lozenges, gummies, chewing gum, and powder or tablet dentifrices. Examples of applications of the composition in a semi-solid dosage form include toothpaste and gel dentifrices. Examples of applications of the composition in a liquid dosage form include mouthwashes, liquid dentifrices, and mouth fresheners (sprays, etc.). The oral composition of the present invention provides a good moisturizing sensation, suppresses the feeling of powderiness, and has good physical properties such as shape retention and stringiness, so it is preferable to use the composition in the form of a dentifrice (toothpaste, gel dentifrice) or a coating agent (oral moisturizing gel, oral moisturizing cream).

[Method of producing the composition]
The method of producing the oral composition is not particularly limited, and it can be prepared by a conventional method according to the dosage form. For example, when it is used as a toothpaste, it can be a method of preparing the components that dissolve in the solvent, mixing the other insoluble components, and degassing (e.g., reducing pressure, etc.) as necessary. The obtained toothpaste can be put into a container to make a product. The shape and material of the container are not particularly limited, and a container that is used for a conventional oral composition can be used, for example, a container such as a laminated tube made of plastic such as polyethylene, polypropylene, polyethylene terephthalate, nylon, etc.

The present invention will be specifically described below with reference to examples and comparative examples. The present invention is not limited to the following examples. The values in the following tables represent mass % unless otherwise specified.

Examples 1 to 25 and Comparative Examples 1 to 9
[Components used in the Examples and Comparative Examples]
-Component (A)-
Calcium carbonate (heavy calcium carbonate, manufactured by Calfine Co., Ltd.)
Silica anhydride (manufactured by Evonik, trade name: Carplex (registered trademark) #67Q)
-Component (B)-
Sodium polyacrylate (manufactured by Toagosei Co., Ltd., product name: Rheogic (registered trademark) 250H)
Carboxyvinyl polymer (manufactured by Lubrizol, product name: Carbopol (registered trademark) 980)
Carrageenan (CP Kelco Japan Co., Ltd.)
Sodium carboxymethylcellulose (manufactured by Daicel Finechem, product name: CMC1260)
-Component (C)-
N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide: (manufactured by Takasago International Corporation, product name: Coolact (registered trademark) 370)
-Fragrance component used in place of component (C) in the comparative examples-
N-ethyl-p-menthane-3-carboxamide: (manufactured by Symrise Japan, product name: WS-3)

The above ingredients were mixed in a conventional manner to prepare a toothpaste composition having the composition shown in the table below, which was then packed in a laminated tube.

[Evaluation method]
Ten testers evaluated the thickening feeling, brushability, and shape retention derived from the inorganic powder contained in the toothpaste composition by calculating the average score of the 10 testers according to the following criteria. In this example, an average score of 3.0 or more was considered to be a pass mark for each evaluation item.

<Thick feeling>
One gram of each toothpaste composition was placed on a toothbrush (Clinica Advantage Toothbrush, 4-row compact regular type, manufactured by Lion Corporation), and the thick feeling felt in the oral cavity due to the inorganic powder was evaluated when the toothbrush was brushed in the usual manner.
Judgment criteria 5 points: No thick feeling in the mouth 4 points: Almost no thick feeling in the mouth 3 points: A slight thick feeling in the mouth, but not bothersome 2 points: A thick feeling in the mouth 1 point: A strong thick feeling in the mouth Evaluation criteria ☆: Average score of 4.5 points or more ◎: Average score of 4.0 points or more and less than 4.5 points ○: Average score of 3.0 points or more and less than 4.0 points △: Average score of 2.0 points or more and less than 3.0 points ×: Average score of 1.0 points or more and less than 2.0 points

<Brushability>
1 g of the toothpaste composition was placed on the toothbrush, and when brushing in the usual manner, the brushing properties felt in the oral cavity were evaluated.
Evaluation criteria: 4 points: Very easy to clean; 3 points: Easy to clean; 2 points: Not very easy to clean; 1 point: Not easy to clean; Evaluation criteria: ◎: Average score of 3.5 to 4.0 points; ○: Average score of 3.0 to less than 3.5 points; △: Average score of 2.0 to less than 3.0 points; ×: Average score of 1.0 to less than 2.0 points

<Shape retention>
A toothpaste composition (length: 10 mm) was extruded onto the toothbrush, and the shape of the toothpaste composition after 3 minutes was visually observed to evaluate its shape retention.
Judgment criteria 4 points: No change in shape, no dripping from the toothbrush 3 points: Slight change in shape, but no dripping from the toothbrush 2 points: Slight change in shape, some dripping from the toothbrush 1 point: Change in shape, some dripping from the toothbrush Evaluation criteria ◎: Average score of 3.5 to 4.0 points ○: Average score of 3.0 to less than 3.5 points △: Average score of 2.0 to less than 3.0 points ×: Average score of 1.0 to less than 2.0 points

Comparative Example 1, which does not contain the (A) component, had a low brushing sensation, and Comparative Example 2, which does not contain the (B) component, had low shape retention. Furthermore, Comparative Examples 3 to 7, which contain more than 1.5% by mass of the (B) component, and Comparative Examples 8 and 9, which do not contain the (C) component, did not eliminate the thick feeling, and Comparative Example 9, which contains N-ethyl-p-menthane-3-carboxamide instead of the (C) component, did not eliminate the thick feeling. In contrast, all of the Examples, which contain the (A) to (C) components and have a content of the (B) component of 0.5 to 1.5% by mass, were able to obtain satisfactory results, with an average score of 3.0 or more, in all evaluations of thick feeling, brushability, and shape retention. These results show that the oral composition according to the present invention has a good usability in addition to shape retention and brushability.

Claims (7)

(A) an inorganic powder;
(B) a water-soluble polymer;
(C) N-(2-hydroxy-2-phenylethyl)-2-isopropyl-5,5-dimethylcyclohexane-1-carboxamide,
The content of the (B) component is 0.5 to 1.5 mass %,
The water-soluble polymer is at least one selected from the group consisting of the following (B1) and at least one selected from the group consisting of (B2):
(B1) Carrageenan, sodium alginate, xanthan gum and sodium carboxymethylcellulose
(B2) sodium polyacrylate, carboxyvinyl polymer and acrylic acid-maleic anhydride copolymer;
An oral composition , wherein the content ratio (B1)/(B2) of the component (B1) to the component (B2) is 1.5 to 9. The oral composition according to claim 1, wherein the inorganic powder is an inorganic calcium salt. The oral composition according to claim 1 or 2, wherein the content ratio (B1)/(B2) is 5 or more. The oral composition according to any one of claims 1 to 3, wherein the content of component (B1) is 0.1 to 1.4 mass%. The oral composition according to any one of claims 1 to 4, wherein the content of component (A) is 10 to 60 mass%. The oral composition according to any one of claims 1 to 5, wherein the content of component (C) is 0.00001 to 0.01% by mass. The oral composition according to any one of claims 1 to 6, which is a dentifrice composition.