JP6943941B2 - Injectable and cosmetic compositions containing lemon balm extract as an active ingredient - Google Patents

Description

The present invention relates to injections and cosmetic compositions containing lemon balm extract as an active ingredient.

In general, an elongated V-line face is the face type that everyone likes. In particular, recently, there is a tendency for many people to break away from the round face and form a small, deeply carved face line.

For the purpose of liposuction, a composite injection using phosphatidylcholine (PP) and deoxycholic acid (sodium deoxycholate) has been widely used for local obesity.

However, due to the generation of fat necrosis due to the injection of a complex preparation using phosphatidylcholine and deoxycholic acid, a lipolytic composition using a single preparation of deoxycholic acid excluding phosphatidylcholine has been developed. In the case of a lipolytic composition using a single preparation of cholic acid, there is a problem that side effects such as edema, erythema, pain, and skin cirrhosis frequently occur.

On the other hand, cosmetics is a synthetic word of cosmetics and pharmaceuticals, and means medicinal cosmetics. It is a product that combines pharmaceutical ingredients with verified efficacy into cosmetics. Cosmetics in which medical professionals such as doctors and pharmacists participated in research and development also belong to cosmetics. If the existing cosmetics are for skin care, cosmetic products are focused on skin treatment.

There is a constant growing demand for slimming and anti-cellulite cosmetics that are effective in removing excess subcutaneous fat and increasing skin elasticity.

An object of the present invention is to solve the above-mentioned problems of the prior art, and an object of the present invention is to provide an injection composition that easily elongateds a face only by injection.

An object of the present invention is to provide a cosmetic composition that can be applied to the skin to directly decompose fat in adipocytes and exhibit a cellulite removing effect.

According to the examples of the present invention, there is provided an injection composition for lipolysis containing a lemon balm extract as an active ingredient.

According to the examples of the present invention, a lemon balm extract, a horse chestnut extract, a rockweed extract, a walnut wrack extract, a walnut (Juglans Regia) extract, an ADP (Disodium Adenosine Triphosphate) The agent composition is provided.

According to the examples of the present invention, there is provided an injection composition for lipolysis containing the above composition as an active ingredient.

According to the first embodiment of the present invention, sodium chloride 0.898% by weight, propylene glycol 0.11462% by weight, phenoxyethanol 0.0468% by weight, methylpropanediol 0.04% by weight, lemon balm extract 0.01875% by weight. , Tyrosine 0.00800% by weight, Pseudomonas aeruginosa seed extract 0.00560% by weight, Walnut extract 0.00560% by weight, Ethylhexyl glycerin 0.00520% by weight, Hibamata extract 0.00240% by weight, Methylsilanol mannurone Active ingredient is lemon balm extract containing 0.00180% by weight of acid, 0.00100% by weight of sorbic acid, 0.00024% by weight of adenosine phosphate, 0.00024% by weight of disodium adenosine triphosphate, and the remaining amount of purified water. To provide an injectable composition.

According to the second embodiment of the present invention, purified water, sodium chloride, lemon balm extract, sardine seed extract, walnut extract, tyrosine, hibamata extract, adenosine phosphate, adenosine triphosphate. Provided is a cosmetic composition containing a lemon balm extract containing disodium acid (DISODIUM ADENOSINE TRIPHOSPHATE), methylpropanediol (METHYLPROPANEDIOL), and methylsilanol mannuronic acid (METHYLSILANOL MANNURONATE) as an active ingredient.

According to the third embodiment of the present invention, in the cosmetic composition,
Sodium chloride 0.898% by weight, lemon balm extract 0.01875% by weight, tyrosine 0.00800% by weight, green beetle seed extract 0.00560% by weight, walnut extract 0.00560% by weight, hibamata extract 0.00240% by weight %% by weight, 0.00024% by weight of adenosine phosphate, 0.00024% by weight of disodium adenosine triphosphate, 0.04000% by weight of methylpropanediol, 0.00180% by weight of methylsilanol mannuronic acid, and purified water remaining. Including
The composition provides a cosmetic composition containing a lemon balm extract as an active ingredient, which is characterized by being applied to the skin by an ultrasonic device, a high frequency device, electroporation, or a needleless injection.

According to the present invention, it is possible to provide an injection composition in which the face is easily elongated only by injection.

According to the present invention, it is possible to provide a cosmetic composition in which the lemon balm extract is used as an active ingredient to decompose the fat in the area to be applied and remove cellulite.

It is a graph which showed the clinical result which performed the injection composition by the Example of this invention. It is an enlarged photograph which showed the tissue in which the adipocyte was distributed before injecting the injection composition into the adipocyte according to the Example of this invention. It is an enlarged photograph which showed the tissue which adipocyte decreased by 80% after the injection composition by the Example of this invention. The photographs before and after the treatment using the injectable composition according to the example of the present invention for 4 weeks are shown. The photographs before and after the treatment using the injectable composition according to the example of the present invention for 4 weeks are shown. It is a graph which showed the clinical result which performed the cosmetic composition by the Example of this invention. It is a graph which showed the clinical result which performed the cosmetic composition by the Example of this invention. Photographs before and after the treatment of the cosmetic composition according to the examples of the present invention for 4 weeks are shown. Photographs before and after the treatment of the cosmetic composition according to the examples of the present invention for 4 weeks are shown.

Hereinafter, specific examples of the present invention will be described in detail with reference to the accompanying drawings.

The lipolytic composition containing the lemon balm extract according to the examples of the present invention as an active ingredient may be administered subcutaneously with an injection for lipolysis, lymphatic circulation, V-line face, elastic face or cosmetic composition. It can be applied as an object.

The composition according to the embodiment of the present invention is injected into sites such as upper eyelid fat, current fat, cheek meat, cheekbone, mouth fat, chin line, and double chin to correct the facial line through lipolysis. Can be done. It is an effective composition that allows delicate engraving depending on the individual's facial condition. It works to relieve edema, lipolysis, promote lymphatic circulation, and anti-cellulite.

The injectable composition for lipolysis according to the examples of the present invention may contain lemon balm extract, horse chestnut (Aesculus Hippocastanum) extract, hibamata extract, walnut extract, ADP (Disodium Adenosine Phosphate), and Adenosine Triphosphate. preferable.

The lipolytic injection composition according to the first embodiment of the present invention is preferably composed of the following components.

表１は、本発明の第１実施例による注射剤組成物の成分及び配合割合を示した表である。数字は重量％を示す。

Table 1 is a table showing the components and blending ratios of the injection composition according to the first embodiment of the present invention. The numbers indicate% by weight.

Lemon balm (Melissa officinalis) is a plant belonging to the family Labiatae, and has a variety of active flavonoids (cinaroside, cosmosin, ramnocitrin and rhamnocitrin, isoquercitrin, isoquercitrin) It is known to contain (triterpene acids: ursolic acid and oleanolic acid) (Herodez SS, Hadolin M, Skerget M, Knez Z Solvent extremation study L) actives such as leaves Food Chemistry 200; 80: 275-82), essential oils, coffee acid and losolic acid, monoterpenes and sesquiterpenes, phenolic substances and tannins were also separated and extracted from lemon balm. To date, lemon balm extract antiseptic (Ulbricht C, Blender T, Grüenwald J, Kligler B, Keifer D, Abrams TR, Woods J, Boon H, Kirkwood balm (Melissa officinalis L): an evidence-based systematic review by the Natural Standard Research Collaboration J Herb Pharmacother R, Karabulut-Bulan O, Yesilyaprak B Protective role of Melissa officinalis L extract on liver of hyperlipidemic rats: a morphological and biochemical study J Ethnopharmacol 2005; 99: 391-8, Ali Zarei1, Saeed Changizi Ashtiyani, Soheila Taheri, Fateme Rasekh Comparison beween effects of different doses of officinal systematic review on the activity of liver enzymes in hypercholesterolemia rats AJP 2014; 4 (1). Lemon balm extract is a Melissa officinalis leaf extract that grows naturally on the Mediterranean coast and in the central part, and as an herbal plant also called "Melissa", it is characterized by a scent similar to lemon and contains a rich rosmarinic acid component. Rosmarinic acid helps with diet, antioxidant and anti-inflammatory effects. Lemon balm extract is a polyphenol and tannin component and has an excellent effect on skin protection. The lemon balm extract is prepared by extracting the whole lemon balm plant, preferably the leaves of lemon balm, with water, methanol, ethanol and a polar solvent selected from the group consisting of a mixture of two or more kinds thereof, preferably water, and spray-drying. It is powdered.

Horse chestnut seed extract (AESCULUS HIPPOCASTANUM (HORSE CHESTNUT) SEED EXTRAC), one of which is called horse chestnut seed extract, has anti-edema effect, anti-inflammatory effect, prevention of edema formation on vascular tissue wall, and reduction of drug feeding property. Not only that, it protects the skin from ultraviolet rays, prevents liver spots, and has the effect of preventing rough skin.

Walnut extract (JUGLANS REGIA (WARNUT) SEED EXTRACT) promotes the differentiation of the stratum corneum by keratinogenic cells in cells, restores the barrier function of damaged skin, and has an excellent effect on increasing and maintaining moisturizing power. Not only that, it is excellent in inhibiting keratinocytes in mast cells and proliferating immune cells, and has anti-inflammatory and stimulating alleviating effects.

Rockweed extract is a component extracted from large brown algae seaweed, contains a large amount of minerals, vitamins and amino acids, and has the effect of protecting the skin and moisturizing rough and dry skin. Absorbs fat and helps eliminate waste products.

Sodium chloride (SODIUM CHLORIDE) is an inorganic salt component that is a compound of sodium (sodium) and chloride (chloride), and is used as an acidity adjuster, antiseptic function, flavoring agent, and viscosity enhancer in cosmetics and beauty products. ..

Propylene glycol (PROPYLENE GLYCOL) is a component obtained by hydrolyzing propylene oxide, has a small molecular weight, has excellent skin penetrating power, and is used for permeating an active ingredient. It has the effect of maintaining the moisture in the skin and improving the moisturizing power of the skin.

Phenoxyethanol (PHENOXYETHANOL) is a component in which phenol and ethylene glycol are combined, and is a component that mainly acts as a preservative and a fixative in cosmetics, and is used in cosmetics instead of paraben, which was once notorious for breast cancer. It is one of the alternative preservatives to be used.

Methylpropanediol is a type of glycol used in solvents. Helps various ingredients (such as salicylic acid) penetrate the skin. It has a hydrating attribute and helps to soften and moisturize the skin.

Tyrosine is a skin amino acid that initiates the production of melanin. It promotes lipid metabolism as a precursor of catecholamines in the body and thyroxine, which is a thyroid hormone.

Ethylhexyl glycerin (ETHYLHEXYLGLYCERIN) is an organic compound component as glyceryl ether, and is a kind of wetting agent having softness, wetting agent and appropriate bleeding performance as one kind of glycerin. The antibacterial activity of preservatives such as phenoxyethanol, isothiazolinone, and parabens can be increased to reduce the amount of preservatives used. It suppresses bacterial growth, has a deodorizing effect, and imparts skin conditioning.

Methylsilanol mannuronic acid (METHYLSILANOL MANNURONATE) is a substance in which silanol, which is an organic silicone organic silicon (SI), and mannuronic acid, which is derived from alginic acid of brown algae, are bound to each other, and has skin regeneration and elasticity. It strengthens, prevents linear skin atrophy, and has antioxidant, lipolytic, and moisturizing effects.

Sorbic acid (SORBIC ACID) is a component present in berries such as blueberries, has an effect of suppressing the growth of microorganisms such as bacteria and molds, and is mainly used as an antiseptic component in all cosmetics. It is an ingredient that is acceptable not only for cosmetics but also for foods.

Adenosine phosphate is a complex, wrinkle-improving, anti-inflammatory, sedative, and cell-interactive component that transmits skin cell-activating oxygen within the dermis to enhance fibroblast size growth and proliferation. Promotes collagen synthesis.

Adenosine triphosphate disodium is a disodium salt component of adenosine triphosphate. It is used to give conditioning to the skin.

If the cheekbones develop and the impression looks strong, if the chin fat (jowl fat), chin line, etc. hang down as you get older, if the cheeks next to the chin line make the chin line look deeper, if the cheeks or double chin If you have a lot of fat, if Botox alone does not calibrate your square chin, if your face line does not calibrate even after contouring or chin-shaving surgery, if you are afraid of fat inhalation or surgery, fat transplantation It is intended for patients with facial asymmetry before / after lifting, patients who desire an elongated face in a short period of time without any problem in daily life, if the existing lipolytic drugs are not effective.

The clinical results of injectable dosing are as follows.

The patient age is for male and female patients in their twenties and over. This is the result after performing 4 times for 1 month, once a week. As a treatment method, after being intoxicated with an ointment for 30 to 40 minutes, 32G needle (1cc syringe) and Mesogun were used. Lemon balm composition Solution is injected subcutaneously (SQ level) in 3-4 points per cc. After the treatment, massage softly with antibiotic ointment or Vit. Apply K ointment.

The following Table 2 is a table showing the number of treatments, the dose, and the interval for each treatment site.

施術者は、８０〜９０％以上効果を示した。全体的な様子の中で、あご脂肪とあご線が最もドラマチックに変化する様子を示し、効果は２〜３週から確実に表れた。薬物使用後、浮腫やしゃく熱感がなく、日常生活に不便がなかった。糸リフティングとボトックス施術が必要な患者の場合、併行施術で満足度がさらに高くなった。特に、輪郭薬物はリンパ代謝にも関与して浮腫緩和とセルライト分解に優れた効果を表した。即ち、図１に示すように、１９％が硬いセルライト減少を示し、３２％が浮腫性セルライト減少を示し、４９％が柔かいセルライト減少効果を示した。

The practitioner showed an effect of 80 to 90% or more. In the overall appearance, the chin fat and chin line changed most dramatically, and the effect was definitely shown from 2 to 3 weeks. After using the drug, there was no edema or a feeling of heat, and there was no inconvenience in daily life. For patients who required thread lifting and Botox, the concurrent procedure was even more satisfying. In particular, contour drugs were also involved in lymphatic metabolism and showed excellent effects on edema relief and cellulite degradation. That is, as shown in FIG. 1, 19% showed a decrease in hard cellulite, 32% showed a decrease in edematous cellulite, and 49% showed a decrease in soft cellulite.

FIGS. 2 and 3 show electron micrographs showing an experiment in which the composition according to the embodiment of the present invention reacted with adipocytes. FIG. 2 is a photograph before the addition of the composition, and FIG. 3 is a photograph after the addition of the composition. The red circles indicate adipocytes, and it can be confirmed that about 80% of adipocytes are reduced.

FIGS. 4 and 5 show photographs before and after the treatment using the injectable composition according to the embodiment of the present invention for 4 weeks, respectively. As shown in the figure, dramatic changes in the facial line can be confirmed by decomposition of fat and cellulite for the first time in 4 weeks.

On the other hand, the cosmetic composition containing the lemon balm extract according to the second embodiment of the present invention as an active ingredient will be described below.

The lipolytic cosmetic composition containing the lemon balm extract according to the embodiment of the present invention as an active ingredient may be applied as a cosmetic composition for lipolysis, lymphatic circulation, V-line face, and elastic face. can.

The lipolytic composition according to the examples of the present invention preferably contains lemon balm extract, horse chestnut (Aesculus Hippocastanum) extract, hibamata extract, walnut extract, ADP (Disodium Adenosine Phosphate), and Adenosine Triphosphate.

The lipolytic cosmetic composition according to the second embodiment of the present invention is preferably composed of the following components.

表３は、本発明の第２実施例による脂肪分解用化粧料組成物の成分及び配合割合を示した表である。数字は重量％を示す。

Table 3 is a table showing the components and blending ratios of the cosmetic composition for lipolysis according to the second embodiment of the present invention. The numbers indicate% by weight.

The description of the efficacy of the same ingredient as in the first embodiment will be omitted.

The lemon balm extract is prepared by extracting the whole lemon balm plant, preferably the leaves of lemon balm, with water, methanol, ethanol and a polar solvent selected from the group consisting of a mixture of two or more kinds thereof, preferably water, and spray-drying. It is powdered. In this example, the effect of reducing fat and cellulite was utilized when the lemon balm extract was applied to the skin.

Using the above composition, clinical practice was performed on 100 non-operators from January to March 2019.

Non-practitioners were classified into non-practitioner cellulite types as shown in Table 4 below.

非施術者の年齢は次の通りであった。７０％の非施術者が１５〜３５歳であった。

The ages of non-practitioners were as follows. 70% of non-practitioners were 15-35 years old.

循環系系統疾病が特に重要であるが、セルライトと関連した症状は、下記の表６のように非常に多様であった。

Although cardiovascular disease is of particular importance, the symptoms associated with cellulite were very diverse, as shown in Table 6 below.

表６から分かるように、６５％の非施術者が静脈還流欠乏（ｄｅｆｉｃｉｅｎｔ ｖｅｎｏｕｓ ｒｅｔｕｒｎ）、４４％が家族歴の静脈瘤血管異常（ｆａｍｉｌｙ ｈｉｓｔｏｒｙ ｏｆ ｖａｒｉｃｏｓｅ ｖｅｉｎｓ）、３１％が少なくとも生理２日前にくるぶし浮腫（ｍａｌｌｅｏｌａｒ ｅｄｅｍａ）を表した。全てのこのような症状が血管と関連が非常に深い（ｖａｓｃｕｌａｒ ｍａｎｉｆｅｓｔａｔｉｏｎｓ）ため、貧弱な循環機能（ｐｏｏｒ ｃｉｒｃｕｌａｔｏｒｙ ｆｕｎｃｔｉｏｎ）と美容学的セルライト問題（ｅｓｔｈｅｔｉｃ ｃｅｌｌｕｌｉｔｅ ｐｒｏｂｌｅｍｓ）と関係があることが統計的に証明された。

As can be seen from Table 6, 65% of non-practitioners have deficient venous vein, 44% have family history of varicose veins, and 31% have ankles at least 2 days before physiology. It represented edema (malleolar edema). Statistically proven that all such symptoms are associated with poor circulatory functions and cosmetic cellulite problems, as they are so closely associated with vascular disease. Was done.

Electroporation was applied to the entire area of the operation, including the peritrochanteric area and the inside of the knee, and the following results were obtained. Electroporation, which means electroporation, is more effective at formula absorption, such as the composition according to the embodiments of the present invention, because it applies an electrical pulse to the skin lipids to temporarily open the skin lipids.

The clinic progressed once a week for 4-10 weeks depending on the condition of the non-practitioner. After that, it progressed once every other week, a total of two times, and after the two times, it progressed only once a month for the purpose of "maintenance". The time per session was from a minimum of 30 minutes to a maximum of 40 minutes, and the power level was 75 to 90%. Note that the massage is done in a soft circle on the application site. Excluding the "maintenance purpose" treatment, 71% of the non-practitioners received a total of 5 to 10 treatments, and 11 to 20 non-treatments including the "maintenance purpose" treatment. 25% of the patients and 4% of the non-operators received 21 times or more.

The changes in weight loss are shown in Table 7 below.

図６は、転子周囲（ｐｅｒｉｔｒｏｃｈａｎｔｅｒｉｃ）の直径減少幅を示したグラフである。２１％が２ｃｍ、４６％が３ｃｍ、２１％が４ｃｍの減少効果を表した。

FIG. 6 is a graph showing the diameter reduction width around the trochanter. 21% showed a reduction effect of 2 cm, 46% showed a reduction effect of 3 cm, and 21% showed a reduction effect of 4 cm.

FIG. 7 is a table showing the comprehensive evaluation of non-practitioners. A non-practitioner's subjective evaluation of the treatment is performed, and the evaluation criteria include not only changes in body weight, but also the degree of symptom group (side effects) that can appear during the treatment process and quick return to daily life. ing.

General vasodilation in both thighs was observed in 3% of non-operators. It was transient, painless, and not a vagal symptom. It is a phenomenon in which the lower thigh part becomes dim and red and then disappears, and it is understood that it is only a reaction to the same type of therapeutic product.

A notable fact is that none of the non-practitioners who participated in the clinic developed resistance and did not show rejection of the same type of therapy. The non-practitioner's acceptance of the product was very good, with no itchiness, swelling, allergic phenomena, distress, or severe erythema.

FIG. 8 is a photograph of a 29-year-old woman before (a) and after (b) the treatment. This is the result of 6 treatments, once a week.

FIG. 9 is a photograph of a 43-year-old woman before (a) and after (b) the treatment. This is the result of 10 treatments once a week.
As shown, dramatic changes can be confirmed by the decomposition of fat and cellulite at the treatment site.

Claims (1)

The lemon balm extract a cosmetic composition comprising, as an active ingredient,
Contains lemon balm extract, sodium chloride, hibamata extract, horse chestnut seed extract, walnut (JuglansRegia) extract, tyrosine, disodium adenosine triphosphate, adenosine phosphate, methylpropanediol, methylsilanol mannuronic acid,
The composition, ultrasound equipment, high-frequency equipment, applied to the skin by electroporation or without needle injected,
The composition is
Sodium chloride 0.898% by weight, lemon balm extract 0.01875% by weight, tyrosine 0.00800% by weight, green beetle seed extract 0.00560% by weight, walnut extract 0.00560% by weight, hibamata extract 0.00240% by weight %% by weight, 0.00024% by weight of adenosine phosphate, 0.00024% by weight of disodium adenosine triphosphate, 0.04000% by weight of methylpropanediol, 0.00180% by weight of methylsilanol mannuronic acid, and purified water remaining. cosmetic composition comprising, as an active ingredient, lemon balm extract, which comprises a.

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