CN119367500A - A Chinese medicine composition for hair growth - Google Patents
A Chinese medicine composition for hair growth Download PDFInfo
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- CN119367500A CN119367500A CN202411618231.9A CN202411618231A CN119367500A CN 119367500 A CN119367500 A CN 119367500A CN 202411618231 A CN202411618231 A CN 202411618231A CN 119367500 A CN119367500 A CN 119367500A
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- 239000003814 drug Substances 0.000 title claims abstract description 43
- 230000003779 hair growth Effects 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 title claims abstract description 21
- 230000001737 promoting effect Effects 0.000 claims abstract description 17
- 235000008331 Pinus X rigitaeda Nutrition 0.000 claims abstract description 15
- 241000018646 Pinus brutia Species 0.000 claims abstract description 15
- 235000011613 Pinus brutia Nutrition 0.000 claims abstract description 15
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract description 15
- 235000008397 ginger Nutrition 0.000 claims abstract description 15
- 235000004072 Ocimum sanctum Nutrition 0.000 claims abstract description 11
- 238000002360 preparation method Methods 0.000 claims abstract description 8
- 244000273928 Zingiber officinale Species 0.000 claims abstract 3
- 239000000284 extract Substances 0.000 claims description 13
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 239000000463 material Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 8
- 239000002994 raw material Substances 0.000 claims description 8
- 239000003826 tablet Substances 0.000 claims description 3
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- 239000008187 granular material Substances 0.000 claims description 2
- 239000002674 ointment Substances 0.000 claims description 2
- 239000006187 pill Substances 0.000 claims description 2
- 239000000843 powder Substances 0.000 claims description 2
- 239000006188 syrup Substances 0.000 claims description 2
- 235000020357 syrup Nutrition 0.000 claims description 2
- 240000002837 Ocimum tenuiflorum Species 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 1
- 238000000967 suction filtration Methods 0.000 claims 1
- 238000009210 therapy by ultrasound Methods 0.000 claims 1
- 210000004209 hair Anatomy 0.000 abstract description 30
- 230000000694 effects Effects 0.000 abstract description 16
- 210000003780 hair follicle Anatomy 0.000 abstract description 15
- 201000004384 Alopecia Diseases 0.000 abstract description 13
- 240000002924 Platycladus orientalis Species 0.000 abstract description 11
- 231100000360 alopecia Toxicity 0.000 abstract description 10
- 244000136948 Ocimum sanctum Species 0.000 abstract description 9
- 230000012010 growth Effects 0.000 abstract description 5
- 241000213006 Angelica dahurica Species 0.000 abstract description 2
- 230000008859 change Effects 0.000 abstract description 2
- 241000699670 Mus sp. Species 0.000 description 20
- 210000004761 scalp Anatomy 0.000 description 18
- 241000234314 Zingiber Species 0.000 description 12
- 210000003491 skin Anatomy 0.000 description 12
- 229940079593 drug Drugs 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 238000010298 pulverizing process Methods 0.000 description 5
- 208000003251 Pruritus Diseases 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000007803 itching Effects 0.000 description 4
- 235000019640 taste Nutrition 0.000 description 4
- 241000699666 Mus <mouse, genus> Species 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 208000024963 hair loss Diseases 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 230000003658 preventing hair loss Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 230000001174 ascending effect Effects 0.000 description 2
- 230000003676 hair loss Effects 0.000 description 2
- 230000001965 increasing effect Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 235000019633 pungent taste Nutrition 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 230000017423 tissue regeneration Effects 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 206010043189 Telangiectasia Diseases 0.000 description 1
- 206010044625 Trichorrhexis Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000003698 anagen phase Effects 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 230000035617 depilation Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 208000002173 dizziness Diseases 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000000750 endocrine system Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229960004039 finasteride Drugs 0.000 description 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 238000000227 grinding Methods 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 230000034756 hair follicle development Effects 0.000 description 1
- 230000003661 hair follicle regeneration Effects 0.000 description 1
- 230000003662 hair growth rate Effects 0.000 description 1
- 230000003814 hair luster Effects 0.000 description 1
- 230000001976 improved effect Effects 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 230000008338 local blood flow Effects 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 230000036564 melanin content Effects 0.000 description 1
- 230000004630 mental health Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 230000036299 sexual function Effects 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 208000009056 telangiectasis Diseases 0.000 description 1
- 230000003797 telogen phase Effects 0.000 description 1
- 229940098465 tincture Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/15—Pinaceae (Pine family), e.g. pine or cedar
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for promoting hair growth, a preparation and application thereof, wherein the traditional Chinese medicine composition comprises biota orientalis, pine needle, ginger, dahurian angelica root, herba lycopi and holy basil. The invention discovers and verifies that the traditional Chinese medicine composition and the preparation thereof have the effect of treating alopecia, can shorten the growth cycle of hair, increase the number of hair follicles, change the hair follicle morphology and achieve the effect of treating alopecia.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for hair growth, a preparation and application thereof.
Background
The normal person can lose hair within 100 pieces per day, and the normal person belongs to physiological alopecia and is the normal metabolism phenomenon of the organism. Alopecia is a common skin disease in clinic, the incidence rate of which rises year by year, is difficult to cure, and develops in a younger trend, and is puzzled with the lives of more and more people. Although hair loss does not affect the physical health of the patient, there are serious negative effects on both quality of life and mental health. Data published by the national Wei Jian Committee 2019 shows that China has over 2.5 million people with alopecia, about 1.63 million men and about 0.88 million women, on average, 1 person per 6 people.
Existing hair-growing drugs, such as minoxidil tincture and finasteride tablets, can effectively promote hair growth, but can be accompanied by side effects such as dizziness, palpitation and sexual function influence. Although the hair planting operation has lasting effect, the cost is high and the application range is limited. In contrast, the invention adopts pure natural medicinal materials, has obvious safety advantage, and obviously reduces adverse effects on the body.
Disclosure of Invention
The first aim of the invention is to provide a traditional Chinese medicine composition for promoting hair growth;
a second object of the present invention is to provide a preparation of the above-mentioned Chinese medicinal composition for promoting hair growth;
the third object of the invention is to provide the application of the traditional Chinese medicine composition for promoting hair growth in preparing a hair-growing medicine.
In order to achieve the above purpose, the invention adopts the following technical scheme:
A Chinese medicinal composition for promoting hair growth is prepared from (by weight parts) folium Platycladi 15-75, folium Pini 10-50, rhizoma Zingiberis recens 3-15, radix Angelicae Dahuricae 3-15, herba Lycopi 3-15 and herba Lysimachiae Foenumgraeci 3-15 by mixing, grinding, adding absolute ethanol, ultrasonic treating for 20min, and suction filtering.
In order to further realize the invention, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight of 60 parts of biota orientalis, 40 parts of pine needle, 12 parts of ginger, 12 parts of radix angelicae, 12 parts of herba lycopi and 12 parts of holy basil.
In order to further realize the invention, the amount of the added absolute ethyl alcohol is 3 times of the total weight of the raw materials.
A Chinese medicinal composition for promoting hair growth is characterized in that the alcohol extract is added with pharmaceutically acceptable auxiliary materials to prepare any one of decoction, granules, pills, tablets, capsules, ointment, syrup and powder.
An application of a Chinese medicinal composition for promoting hair growth in preparing hair growth promoting medicine is provided.
Compared with the prior art, the invention has the beneficial effects that:
The hair-growing traditional Chinese medicine extract can achieve the effects of hair-growing, hair-loss prevention, oil control and itching relief.
Platycladus orientalis leaves are bitter and astringent in taste, cold in nature, cool in nature, and capable of promoting hair growth and blackening hair, shortening the progress of hair follicles from telogen to anagen, promoting hair follicle development, increasing melanin content in hair follicles, and blackening hair.
Pine needles are bitter in taste, warm in nature, capable of dispelling wind and eliminating dampness, killing parasites and relieving itching, firming hair roots, strengthening hair, relieving scalp itching and improving scalp health.
Ginger, rhizoma Zingiberis recens, with pungent taste and slightly warm nature, stimulates scalp, accelerates scalp metabolism, promotes local blood circulation, activates atrophic hair follicle, and promotes hair follicle regeneration.
Radix Angelicae Dahuricae has pungent taste and warm nature, and has effects in reducing scalp oil secretion, removing hair greasy dirt, keeping hair luster, inhibiting scalp bacteria and fungi, and maintaining scalp health.
Herba Lycopi is bitter and pungent in taste, mild in nature, and capable of removing blood stasis and promoting tissue regeneration, nourishing hair, reducing hair breakage and bifurcation, improving hair follicle health condition, and promoting hair growth.
The holy basil is spicy, slightly bitter, warm in nature and aromatic, and can be used for avoiding dirt, removing turbidity, perfuming hair, moisturizing hair, supplementing hair nutrition and moisturizing hair.
The invention is based on the compatible theory of Dunhuang medical corner drugs, takes the basic theory of traditional Chinese medicine as the basis, takes dialectical treatment as the premise, selects similar mutual palps of cacumen biotae, ginger and pine needles according to the compatible principles of four-qi five-flavor, ascending, descending, ascending, descending, and the like of the drugs, and the like, forms corner drugs, has unique formula and has the effects of hair care, hair loss prevention and root strengthening. Wherein the biota orientalis leaves are monarch, the ginger and the pine needle are ministerial, the biota orientalis She Shengfa is anticreep, the ginger activates hair follicles, the pine needle is shaped and shaped, the hair is strengthened, the medicinal properties and the taste of the three materials are combined, the tripod-like situation is formed, and the hair growth is promoted from different dimensions of the scalp, the hair follicles and the hair. Radix Angelicae Dahuricae and herba Lycopi are used as adjuvant drugs, and are pungent and warm, and are combined together to achieve effects of dredging and lowering, dispelling pathogenic wind and removing dampness, reducing scalp oil secretion, removing blood stasis and promoting tissue regeneration, improving scalp metabolism, and regulating scalp local microenvironment. Herba Lysimachiae Foenumgraeci is fragrant, and is effective in preventing dirt and eliminating turbid urine, moistening hair, and keeping hair glossy. The whole formula can play the roles of hair care, hair loss prevention, oil control, itching relief and scalp nourishing.
The invention discovers and verifies that the traditional Chinese medicine composition and the preparation thereof have the effect of treating alopecia, can shorten the growth cycle of hair, increase the number of hair follicles, change the hair follicle morphology and achieve the effect of treating alopecia.
The invention discloses a hair-growing product which integrates the traditional wisdom with the modern requirements, three medicinal materials of cacumen biotae, ginger and pine needle are skillfully selected, and the Dunhuang horn medicament is formed by the same kind of mutual compatibility principle. The Chinese arborvitae She Fuhan nourishes the components, helps to strengthen the hair roots, the ginger can promote the blood circulation of the scalp and activate hair follicles, and the pine needles help to regulate the scalp environment and reduce alopecia. In addition, radix angelicae, herba lycopi and holy basil are added to synergistically increase. Radix Angelicae Dahuricae activates hair follicle, provides necessary nutrients for hair, promotes hair growth, herba Lycopi has effects of inducing diuresis to alleviate edema, regulating endocrine system, improving scalp microenvironment, herba Lysimachiae Foenumgraeci stimulates scalp telangiectasis, optimizing microcirculation, and creating more favorable conditions for hair growth. The medicines have synergistic effect, so that the hair-growing and hair-loss-preventing effects are remarkable, hair roots can be fundamentally strengthened, and hair quality is improved. Compared with other hair-growing products, the invention focuses on natural and healthy combination, and nourishes the scalp mildly and deeply by purely natural ingredients.
The invention not only focuses on hair growth, but also enables the medicine to penetrate into scalp through the transdermal effect of the traditional Chinese medicine composition and the preparation thereof, and then circulate into the human body through blood vessels, thereby achieving the effects of regulating qi and blood balance of the body and optimizing endocrine environment, fundamentally solving the problem of alopecia and providing a more comprehensive and effective hair growing solution for patients.
Drawings
FIG. 1 is a graph showing the back hair growth of mice;
FIG. 2 is a graph showing hair growth scores at various dosing time points for mice;
FIG. 3 is a graph showing the relative area of skin greying on the back of mice at various dosing time points;
FIG. 4 is a graph showing skin darkening time on the back of mice;
FIG. 5 shows the length of the back hair of a 40 day administration mouse;
FIG. 6 shows the observation of hair follicles by hematoxylin-eosin staining of skin pathological tissue sections of the back of mice.
Detailed Description
The invention is further described below with reference to the drawings and the detailed description.
Example 1:
15g of biota orientalis, 10g of pine needle, 3g of ginger, 3g of radix angelicae, 3g of herba lycopi and 3g of holy basil;
Mixing the above materials, pulverizing, adding 111ml anhydrous ethanol, ultrasonic treating for 20min, and vacuum filtering to obtain traditional Chinese medicine extract.
Example 2:
30g of biota orientalis, 20g of pine needle, 6g of ginger, 6g of radix angelicae, 6g of herba lycopi and 6g of holy basil;
Mixing the above materials, pulverizing, adding 222ml anhydrous ethanol, ultrasonic treating for 20min, and vacuum filtering to obtain traditional Chinese medicine extract.
Example 3:
45g of biota orientalis, 30g of pine needle, 9g of ginger, 9g of dahurian angelica root, 9g of herba lycopi and 9g of holy basil;
Mixing the above materials, pulverizing, adding 333ml anhydrous ethanol, ultrasonic treating for 20min, and vacuum filtering to obtain traditional Chinese medicine extract.
Example 4:
60g of biota orientalis, 40g of pine needle, 12g of ginger, 12g of radix angelicae, 12g of herba lycopi and 12g of holy basil;
Mixing the above materials, pulverizing, adding 444ml anhydrous ethanol, ultrasonic treating for 20min, and vacuum filtering to obtain traditional Chinese medicine extract.
Example 5:
75g of biota orientalis, 50g of pine needle, 15g of ginger, 15g of radix angelicae, 15g of herba lycopi and 15g of holy basil;
mixing the above materials, pulverizing, adding 555ml of anhydrous ethanol, ultrasonic treating for 20min, and vacuum filtering to obtain traditional Chinese medicine extract.
Experimental results the medicine prepared in example 5 was observed in animal experiments.
The observed subjects were C57bl/6 male mice, 4-6 weeks old.
The mice were randomly divided into a control group and a dosing group, 6 mice per group were sheared with scissors, and then shaved on both sides of the median line of the back spines of all the mice with an animal shaver to fully expose the skin, and the hair was shaved off with the mouse shaver to a back area of 2cm x 3cm, so that a hair loss model was constructed, and the control group did not undergo any treatment. The administration group was coated with 0.2 mL of the Chinese medicine extract of example 4, and the mice of the Chinese medicine group were coated with the Chinese medicine 2 times daily in the morning and afternoon, each time 60 μl, and the back skin was cleaned with physiological saline before administration to remove the residual medicine of the previous time. The mice were observed daily for skin color changes during the period from depilation to complete coverage of the back skin with hair, and were photographed periodically for recording.
As shown in fig. 1, the hair growth rate was faster in the back skin shaved area of the mice in the dosing group compared to the model group.
As shown in FIG. 2, the growth of the new hair in the dehairing area of the mouse was scored according to the following criteria, 1, 0-20% of the total dehairing area, 2, 20-40% of the total dehairing area, 3, 40-60% of the total dehairing area, 4, 60-80% of the total dehairing area, 5, 80-100% of the total dehairing area. The mice in the dosing group had better growth of the back dehairing zone compared to the model group.
As shown in fig. 3, the area of hair growth in the back dehairing area of mice at various administration time points was measured using ImageJ,
As shown in fig. 4, the time for darkening of the back skin was earlier in the mice of the administration group than in the model group.
As shown in fig. 5, at the same time node, the back hair of the mice in the administration group was longer than that in the model group.
As shown in fig. 6, the number of skin hair follicles on the back of the mice in the administration group was increased as compared with the model group.
As shown in table 1, the time to darken the back skin was reduced in the mice of the examples 1,2,3,4, and the effect was reduced in the example 5, compared to the model group.
It is concluded that the hair-growing Chinese medicine extract can shorten the growth period of hair, increase the number of hair follicles and treat alopecia.
TABLE 1 time to darken skin of mice back after application of the traditional Chinese medicine extracts of examples 1-5 (days, mean.+ -. SD)
As can be seen from Table 1, the darkening time of the back skin of mice after the application of the traditional Chinese medicine extracts of examples 1-5 was earlier than that of the model group.
Claims (5)
1. A traditional Chinese medicine composition for promoting hair growth is characterized by being prepared from the following raw materials, by weight, 15-75 parts of cacumen biotae, 10-50 parts of pine needle, 3-15 parts of ginger, 3-15 parts of radix angelicae, 3-15 parts of herba lycopi and 3-15 parts of holy basil, wherein the extraction method comprises the steps of mixing the raw materials, uniformly mixing the raw materials by a traditional Chinese medicine grinder, crushing the raw materials, adding absolute ethyl alcohol, performing ultrasonic treatment for 20min, and performing suction filtration to obtain a traditional Chinese medicine extract.
2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials, by weight, 60 parts of cacumen biotae, 40 parts of pine needle, 12 parts of ginger, 12 parts of radix angelicae, 12 parts of herba lycopi and 12 parts of holy basil.
3. The Chinese medicinal composition according to claim 1, wherein the amount of the added absolute ethyl alcohol is 3 times of the total weight of the raw materials.
4. A preparation based on the traditional Chinese medicine composition for promoting hair growth according to any one of claims 1-3, which is characterized in that the alcohol extract is added with pharmaceutically acceptable auxiliary materials to prepare any one of decoction, granules, pills, tablets, capsules, ointment, syrup and powder.
5. Use of a Chinese medicinal composition for promoting hair growth according to any one of claims 1 to 4 in the preparation of a hair growth medicament.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411618231.9A CN119367500A (en) | 2024-11-13 | 2024-11-13 | A Chinese medicine composition for hair growth |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411618231.9A CN119367500A (en) | 2024-11-13 | 2024-11-13 | A Chinese medicine composition for hair growth |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN119367500A true CN119367500A (en) | 2025-01-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411618231.9A Pending CN119367500A (en) | 2024-11-13 | 2024-11-13 | A Chinese medicine composition for hair growth |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN119367500A (en) |
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- 2024-11-13 CN CN202411618231.9A patent/CN119367500A/en active Pending
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