CN108452275A - It is a kind of to have effects that the composition, medicament and preparation method of relaxing tendons and activating collaterals - Google Patents
It is a kind of to have effects that the composition, medicament and preparation method of relaxing tendons and activating collaterals Download PDFInfo
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- CN108452275A CN108452275A CN201810241167.5A CN201810241167A CN108452275A CN 108452275 A CN108452275 A CN 108452275A CN 201810241167 A CN201810241167 A CN 201810241167A CN 108452275 A CN108452275 A CN 108452275A
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- 230000003119 painkilling effect Effects 0.000 description 1
- 238000010422 painting Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940116257 pepper extract Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 150000003904 phospholipids Chemical group 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- 239000004302 potassium sorbate Substances 0.000 description 1
- 229940069338 potassium sorbate Drugs 0.000 description 1
- 235000010241 potassium sorbate Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 230000000552 rheumatic effect Effects 0.000 description 1
- 230000033764 rhythmic process Effects 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000004003 subcutaneous fat Anatomy 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000001515 vagal effect Effects 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 150000003710 vitamin D derivatives Chemical class 0.000 description 1
- 229940046008 vitamin d Drugs 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
- 235000019509 white turmeric Nutrition 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
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- Microbiology (AREA)
- Mycology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Having effects that the composition of relaxing tendons and activating collaterals the present invention provides a kind of, including drug component, antiseptic ingredient and promote absorbent components, drug component is used using collocation such as vanillyl butyl ether and ginger oil, enhance the absorption of drug component using the pyrogenic effect of heat sensitizer, apparent relaxing tendons and activating collaterals effect can be generated.Antiseptic ingredient is arranged in pairs or groups using three kinds of ginger-root extract, aloe extract and Schisandra chinens P.E natural plant extracts, has good anti-corrosion effect.Promote absorbent components replaces glycerine and butanediol, moistening effect more preferable using 1,3 propylene glycol of corn fermentation.Compared with traditional plaster and existing relaxing tendons and activating collaterals frost, permeability of the present invention is more preferable, therapeutic effect is notable, have both emollient and moistening effect, skin activity can be enhanced, chemical substance is replaced using natural materials, also increase the security performance of product, product also has the longer shelf-life simultaneously, can stablize storage.The present invention also provides the preparation methods of above-mentioned medicament.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to a kind of composition and preparation method thereof with relaxing tendons and activating collaterals.
Background technology
Modern life rhythm is fast, and diet is irregular, and operating pressure is big, easily leads to and often feels tired out and tired.Industry
The remaining time, which is also all spent, to be chased after acute, object for appreciation game and is playing on mobile phone, lacks exercise, therefore channels and collaterals are not dredged, and QI-blood circulation has some setbacks,
The normal physiological function of internal organs is influenced, fitness goes from bad to worse.External manifestation has shoulder neck, lumbar vertebrae, arm etc. pain uncomfortable.
Alleviate the mainly white with cortex plaster and relaxing tendons and activating collaterals of above-mentioned symptom at present.Traditional cortex plaster smell is denseer,
Poor air permeability easily causes skin certain damage, absorbs slowly, ingredient is single, and remission effect is limited, patient's usage experience
Difference.And existing relaxing tendons and activating collaterals frost, poor permeability, actual effect is bad, and often adds harmful chemical preservative.This
Invention is that providing one kind safely and effectively dredging active, the frost of moisturizing.
CN103405544A discloses a kind of novel blood circulation activating plaster and its preparation method and application, which has four pieces
Watt, deep perfume, radix aconiti agrestis, Forrest Silkvine Stem or Root, raw cape jasmine, borneol, peppermint neurostearic acid, glycerin monostearate, albolene, three ethyl alcohol
Amine and glycerine etc., preparation method include filtering and concentrating, which has promoting blood circulation and removing blood stasis, clearing heat and detoxicating, cool blood detumescence,
The effect of stasis-dispelling and pain-killing, it can be used for that treating rheumatic ostealgia, bruises and sprains and skin and mucous membrane are damaged, however the on the one hand blood circulation activating plaster
Preparation method is more complex, on the other hand, has used noxious material, such as triethanolamine, and 3 classes for belonging to World Health Organization's announcement are carcinogenic
Object, risk are higher.CN1706471 discloses a kind of active plaster and its manufacturing method, for outer patch treatment lumbago, skelalgia of rheumatism, falls
Beat damage etc. caused by swelling, pain, fracture and breaking of muscle and tendon, raw material have Radix Angelicae Sinensis, rheum officinale, radix paeoniae rubra, Radix Curcumae, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, trigone,
Curcuma zedoary, monkshood, radix aconiti agrestis, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, cortex acanthopanacis, windproof, rhizoma nardostachyos, monkshood and radix aconiti agrestis, preparation process include immersion oil oil refining, under
Pellet receives cream plus Huoluo powder and booth painting etc., and medicinal material easily obtains, is at low cost selected by the invention plaster, however plaster application time is longer,
Many people the problems such as especially skin sensitivity group is susceptible to allergy.It is active that CN105147859A discloses a kind of analgesia detoxification
The raw material of cream and preparation method thereof, plaster includes vomiting nut, semen momordicae, capsicum, yellow lead and sesame oil etc., the analgesia detoxification blood circulation activating plaster
Formula have the function of anti-inflammatory analgesic, blood activating and promoting tissue regeneration, improve neural, promoting blood circulation and removing blood stasis, toxin expelling antispastic etc., can effectively activate neural work(
Can, improve blood circulation, accelerate metabolism, restore nervimuscular function, to reach therapeutic purposes, when use directly pastes
It applies in affected part, changes within 5th primary, 3 one courses for the treatment of of patch, the problem of it is long to equally exist application time, skin sensitivity group easy allergy.
Cream needs to be sticked for a long time to maximize realization therapeutic effect because of the characteristics of its absorption is slow, poor permeability, and
The problems such as sticking not only inconvenience for a long time, also will produce skin allergy, therefore on the basis of existing technology, it is necessary to it opens
The blood circulation activating plaster that send out a kind of new should also be avoided simultaneously with solving the problems, such as to absorb slow and poor permeability existing for the active cream of tradition
Human body may be generated the noxious materials such as the chemical addition agent of harm by being added.
Invention content
To solve the problems of the prior art, an object of the present invention, which is to provide, a kind of having effects that the composition of relaxing tendons and activating collaterals.
The second object of the present invention is to provide a kind of to have effects that the medicament of relaxing tendons and activating collaterals.
The third object of the present invention is to provide the preparation method of above-mentioned medicament.
To achieve the above object, the present invention uses following technical scheme：
It is a kind of to have effects that the composition of relaxing tendons and activating collaterals, include the component of following parts by weight meter：
0.2~1 part of ginger oil,
1~3 part of heat sensitizer,
0.5~3 part of penetrating agent,
1~3 part of emulsifier,
5~8 parts of stearic acid,
5~8 parts of cetostearyl alcohol,
1~5 part of Jojoba seed oil,
20~30 parts of ethylhexyl palmitate,
0.1~0.5 part of peppermint oil,
0.3~0.5 part of evodia extract,
0.3~0.5 part of teasel extract,
0.1~0.5 part of borneol.
Preferably, the heat sensitizer is vanillyl butyl ether.
Preferably, the penetrating agent is menthol, and the emulsifier is hydrolecithin.
It is a kind of to have effects that the medicament of relaxing tendons and activating collaterals, including combinations of the above object, also antiseptic ingredient and rush absorbent components.
Preferably, the antiseptic ingredient includes the raw material of following parts by weight meter：
0.3~0.5 part of pH adjusting agent,
0.5~1 part of Schisandra fruit extract,
0.5~1 part of ginger-root extract,
0.2~0.5 part of aloe extract.
Preferably, the pH adjusting agent is arginine, in the aloe extract, Anthraquinone>0.5%.
Preferably, described to promote the raw material that absorbent components include following parts by weight meter：
5~10 parts of moisturizer,
0.1~0.3 part of carbomer,
25~60 parts of water.
Preferably, the moisturizer is 1,3-PD.
A kind of to have effects that the medicament of relaxing tendons and activating collaterals, the dosage form of the medicament is gel, emulsifiable paste.
A kind of preparation method with the medicament of relaxing tendons and activating collaterals, includes the following steps：
(1) each raw material of absorbent components will be promoted to be added in container 1, heating stirring；
(2) each raw material of drug component is added in container 2, heating stirring；
(3) mixture in container 2 is added in container 1, is down to low temperature after high speed is homogeneous, adds uniformly mixed anti-corrosion
Each raw material of component.
Preferably, step (1) and the temperature of (2) are 80~85 DEG C, and the reaction time is 2~5 minutes.
Preferably, the homogeneous rotating speed of step (3) described high speed is 5000rpm, and the low temperature is<50℃.
The present invention has effects that active effect of the composition of relaxing tendons and activating collaterals mainly by vanillyl butyl ether and ginger oil
Collective effect provided.Vanillyl butyl ether is a kind of oil-soluble heat sensitizer, after acting locally on skin, can quickly generate temperature
With lasting pyrogenic effect, microcirculation can be accelerated, stimulation subcutaneous fat is metabolized, and promotes capillary blood cycle.Vanillyl fourth
The thermal sensation of base ether is the several times of general pepper extract, and irritation is low, and the time that thermal sensation is kept is up to a few hours, and can be
Strong thermal sensation can be generated under extremely low dosage.Ginger oil may act on sympathetic nerve and vagal system, be pressed after dilution
Rub the hemostasis that can dissipate, and treats wound.
The main component of cell membrane is phospholipid bilayer, and making emulsifier using hydrolecithin replaces conventional emulsifier,
According to the similar principle that mixes, skin can be promoted preferably to absorb functional component, be further reduced in traditional chemical synthetic emulsifier
Existing specified risk material.
The greases such as dormant oil are replaced using plant SIMMONDSIA CHINENSIS SEED OIL and ethylhexyl palmitate, reduce specified risk material, also, lotus
Lotus bar seed oil has good permeability, can promote the absorption of functional component, also contain abundant vitamin D in Jojoba seed oil
And protein, the pre- anti-wrinkle of energy and softening skin, there are good emollient, moisture retention.
Carbomer is neutralized instead of pH adjusting agents such as traditional triethanolamine, sodium hydroxide, potassium hydroxide using arginine
And organic acid, it is possible to reduce damage of the residual of highly basic to skin, and arginine obtains amino and carboxyl etc. after decomposing, and gives cell
The raw material of synthetic protein is provided.
Escherichia coli, pseudomonas aeruginosa, staphylococcus aureus, Klebsiella Pneumoniae, mould must not be detected in cosmetics
Bacterium and saccharomycete etc..Preservative currently on the market is predominantly slow to hydroxy kind bacteriostatic agent, isothiazolinone bacteriostatic agent, formaldehyde
Release body bacteriostatic agent, alcohols bacteriostatic agent and parabens bacteriostatic agent.Wherein cosmetics relevant laws and regulations to isothiazolinone bacteriostatic agent,
Formaldehyde sustained release bacteriostatic agent and parabens bacteriostatic agent have specific limitation dosage.And alcohols bacteriostatic agent such as Phenoxyethanol, 1,2~
The sterilizing abilities such as hexylene glycol are limited, and fungistatic effect is bad when single use, and Phenoxyethanol also has that there are the risks of dioxanes.
Aloe extract contains anthraquinone analog compound, and anthraquinone can inhibit the synthesis of albumen and nucleic acid, so as to effectively press down
The golden yellow staphylococcus of system, candidiasis, aspergillus oryzae and trichoderma.Ginger-root extract is to gold-coloured staphylococci, hay bacillus, black song
Mould, mould, Escherichia coli and brewer's yeast have stronger inhibiting effect.Schisandra chinens P.E is to Pseudomonas aeruginosa, kerekou pneumonia
The growth of primary Salmonella, Escherichia coli and staphylococcus aureus has very strong inhibiting effect, however is individually extracted with Schisandra chinensis
Object is weaker to the fungistatic effect of staphylococcus aureus, and individually Schisandra chinens P.E cannot antibacterial mould, arrange in pairs or groups ginger
It acts synergistically after root extract and aloe extract apparent, the anti-corrosion ability of system can be improved.The present invention uses Schisandra chinensis
Three kinds of extraction, aloe extract and ginger-root extract extracts have good bacteriostasis, and three kinds carry as protective system
The effects that taking object to have anti-aging, reducing red blood silk, promote collagen synthesis, enhance skin activity, can not only reach anti-corrosion
Effect can also make skin more healthy.
Replace glycerine and butanediol, moistening effect more preferable using the 1,3-PD of corn fermentation.
Beneficial effects of the present invention
1, compared with traditional plaster and existing relaxing tendons and activating collaterals frost, the present invention is using vanillyl butyl ether and ginger oil etc.
Collocation uses, and enhances the absorption of drug component using the pyrogenic effect of heat sensitizer, can generate apparent relaxing tendons and activating collaterals effect；
2, replace chemical substance using natural materials, increase the security performance of product, at the same emollient, moistening effect and
Permeability is more preferable, such as replaces glycerine and butanediol using the 1,3-PD of corn fermentation, moistening effect is better, using plant
SIMMONDSIA CHINENSIS SEED OIL and ethylhexyl palmitate replace the greases such as dormant oil, have good permeability, promote the absorption of functional component；
3, the present invention is taken using three kinds of ginger-root extract, aloe extract and Schisandra chinens P.E natural plant extracts
With use, there is good anti-corrosion effect, the product being prepared to have the longer shelf-life, can stablize storage, also has anti-
The effects that aging reduces red blood silk, promotes collagen synthesis, enhance skin activity, in addition, three kinds of extracts are all powdery,
Avoid the possibility that new preservative is introduced in production process.
Specific implementation mode
The following is specific embodiments of the present invention, and technical scheme of the present invention will be further described in conjunction with the embodiments,
However, the present invention is not limited to these examples.
Embodiment 1
Eight kinds of formulas with the medicament of relaxing tendons and activating collaterals are present embodiments provided, it is specific as shown in table 1.
1 eight kinds of raw material proportionings with the medicament of relaxing tendons and activating collaterals of table
Embodiment 2
The preparation method for present embodiments providing the medicament with relaxing tendons and activating collaterals, the specific steps are：
(1) each raw material of absorbent components will be promoted to be added in emulsification pot, be warmed to 80~85 DEG C, be dispersed with stirring uniformly, react 3 points
Clock；
(2) each raw material of drug component is added in oil phase pot, is warmed to 80~85 DEG C, be dispersed with stirring uniformly, react 3 points
Clock；
(3) emulsification pot side high speed is homogeneous, while mixture in oil phase pot is pumped into emulsification pot, heat preservation high speed 5000rpm is homogeneous
Reaction is down to 50 DEG C after ten minutes, after adding each raw material of uniformly mixed antiseptic ingredient, high speed homogenization 5 minutes, and stirring cooling
It can discharge to 40 DEG C.
Embodiment 3
Has effects that the drug effect of the medicament of relaxing tendons and activating collaterals obtained by the present invention to verify, we are active with certain commercially available money by it
Cream has carried out contrast test.
Subjects totally 200 people exists because the reasons such as long-term sitting lead to that QI-blood circulation is unsmooth, shoulder neck pain asks
Subjects are randomly divided into experimental group and control group by topic, and experimental group has effects that relaxing tendons and activating collaterals using prepared by the present invention
A little blood circulation activating plaster is applied to sore place when use by composition, is massaged about 1 minute or so, and control group uses city with same method
Sell common blood circulation activating plaster.After a week, subjects are evaluated according to pain relief situation, and the results are shown in Table 2 for experiment.
2 present invention of table has effects that the pharmacy effect comparison of relaxing tendons and activating collaterals
| Group | Pain disappears | Pain obviously weakens | There is small effect | Without positive effect |
| Experimental group | 91 | 96 | 4 | 0 |
| Control group | 43 | 65 | 26 | 9 |
In addition, total Test object indicates that the medicament with relaxing tendons and activating collaterals provided by the invention is applying in experimental group
It is fast to smear skin infiltration rate in massage processes, blood circulation activating plaster will not " floating " in skin surface, no greasy feeling, skin is relatively sliding after smearing
Profit, has similar body lotion and the using effect of hand lotion, smell unobvious, total Test object not to occur skin during the test
The allergic phenomenas such as skin is rubescent, itches.In control group, the subjects for being more than 70% indicate that used blood circulation activating plaster is more greasy,
Skin surface is glossy after smearing massage, has grease, blood circulation activating plaster not to fully penetrate into skin, and the subjects for being more than 50% indicate active
Cream has excitement, and local skin is rubescent after a week for continuous use, and blood circulation activating plaster smell is special and strong.
Embodiment 4
The preparation method provided using embodiment 2, according to embodiment 1 provide eight kinds formula, be prepared eight kinds it is right
The relaxing tendons and activating collaterals cream that should be numbered, compared with carrying out performance and effect with two commercially available blood circulation activating plaster A and B, the results are shown in Table 3.
3 eight kinds of table has effects that the powder performance of relaxing tendons and activating collaterals and effect
Wherein, whether qualified standard is whether total plate count, yeast and mold sum meet GB/T to fungistatic effect
29990 requirement.
The formula of commercially available blood circulation activating plaster A is unknown, the formula of commercially available blood circulation activating plaster B, according to its specification, including：Water 70~
75 parts, 5~10 parts of glycerine, 3~5 parts of narrow-leaved lavender essential oil, 1~3 part of safflower oil, 1~3 part of ginger oil, 3~5 parts of white oil, xanthan
0.1~0.5 part of glue, 0.1~0.3 part of Dodecyl Glucoside, polyglycereol~0.1~0.3 part of 2 dimerization hydroxy stearic acid, menthol 1
~3 parts, 0.1~0.5 part of linalool, 2~5 parts of saualane, 0.1~0.5 part of sesame seed oil, 0.5~2 part of gluconic acid, benzene first
0.1~0.5 part of sour sodium, 0.05~0.2 part of potassium sorbate, 0.01~0.05 part of camphor, 3~5 parts of hackmatack berry extract, another name for Sichuan Province
0.1~1 part of certain herbaceous plants with big flowers, 2~5 parts of Cortex Magnoliae Officinalis root extracting solution, 1~4 part of hamamelis extract, 0.01~0.05 part of calcium gluconate, spiceleaf
0.01~0.05 part of alcohol, 0.01~0.05 part of limonene, 0.01~0.05 part of glucolactone, another name for Sichuan Province grass roots extract 0.1~3
Part, 0.1~2 part of devil claw root root extract.
Claims (10)
1. a kind of having effects that the composition of relaxing tendons and activating collaterals, which is characterized in that include the component of following parts by weight meter：
0.2~1 part of ginger oil,
1~3 part of heat sensitizer,
0.5~3 part of penetrating agent,
1~3 part of emulsifier,
5~8 parts of stearic acid,
5~8 parts of cetostearyl alcohol,
1~5 part of Jojoba seed oil,
20~30 parts of ethylhexyl palmitate,
0.1~0.5 part of peppermint oil,
0.3~0.5 part of evodia extract,
0.3~0.5 part of teasel extract,
0.1~0.5 part of borneol.
2. according to claim 1 have effects that the composition of relaxing tendons and activating collaterals, which is characterized in that the heat sensitizer is chinese cymbidium
Base butyl ether.
3. according to claim 1 have effects that the composition of relaxing tendons and activating collaterals, which is characterized in that the penetrating agent is peppermint
Alcohol, the emulsifier are hydrolecithin.
4. a kind of having effects that the medicament of relaxing tendons and activating collaterals, which is characterized in that combined including claims 1 to 3 any one of them
Object, antiseptic ingredient and rush absorbent components.
5. medicament according to claim 4, which is characterized in that the antiseptic ingredient includes the raw material of following parts by weight meter：
0.3~0.5 part of pH adjusting agent,
0.5~1 part of Schisandra fruit extract,
0.5~1 part of ginger-root extract,
0.2~0.5 part of aloe extract.
6. medicament according to claim 5, which is characterized in that the pH adjusting agent is arginine, the aloe extract
In, Anthraquinone>0.5%.
7. medicament according to claim 4, which is characterized in that described to promote the original that absorbent components include following parts by weight meter
Material：
5~10 parts of moisturizer,
0.1~0.3 part of carbomer,
24~59 parts of water.
8. medicament according to claim 7, which is characterized in that the moisturizer is 1,3-PD.
9. according to claim 4~8 any one of them medicament, which is characterized in that the dosage form of the medicament is gel, emulsifiable paste.
10. a kind of preparation method with the medicament of relaxing tendons and activating collaterals, which is characterized in that include the following steps：
(1) each raw material of absorbent components will be promoted to be added in container 1, heating stirring；
(2) each raw material of drug component is added in container 2, heating stirring；
(3) mixture in container 2 is added in container 1, is down to low temperature after high speed is homogeneous, adds uniformly mixed antiseptic ingredient
Each raw material.
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109289059A (en) * | 2018-11-28 | 2019-02-01 | 广州润虹医药科技股份有限公司 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
| CN109700856A (en) * | 2019-01-24 | 2019-05-03 | 广东暨晴生物医药科技有限公司 | A kind of Chinese medicine external prescription relieved pain with promoting blood circulation and removing obstruction in channels, relaxing muscles and tendons |
| CN110721101A (en) * | 2019-10-17 | 2020-01-24 | 广州市瓷颜化妆品有限公司 | Self-prepared two-component essence cream and preparation method thereof |
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| CN113398136A (en) * | 2021-07-23 | 2021-09-17 | 孟庆峰 | Ointment for relaxing tendons and activating collaterals and preparation method thereof |
| CN115245529A (en) * | 2021-04-26 | 2022-10-28 | 上海幼官健康管理有限公司 | A kind of skin penetrant and external pain reliever prepared therefrom |
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| CN109289059A (en) * | 2018-11-28 | 2019-02-01 | 广州润虹医药科技股份有限公司 | A kind of bactericidal medical ultrasonic couplant and preparation method thereof |
| CN109700856A (en) * | 2019-01-24 | 2019-05-03 | 广东暨晴生物医药科技有限公司 | A kind of Chinese medicine external prescription relieved pain with promoting blood circulation and removing obstruction in channels, relaxing muscles and tendons |
| CN110721101A (en) * | 2019-10-17 | 2020-01-24 | 广州市瓷颜化妆品有限公司 | Self-prepared two-component essence cream and preparation method thereof |
| CN111920727A (en) * | 2020-07-09 | 2020-11-13 | 周艳 | Body mud film for diminishing inflammation and expelling toxin and preparation method thereof |
| CN111773122A (en) * | 2020-07-28 | 2020-10-16 | 广州环亚化妆品科技有限公司 | Heating mask with moistening effect and preparation method thereof |
| CN112294733A (en) * | 2020-10-27 | 2021-02-02 | 广州真润生物科技有限公司 | Foot mask with warming nursing effect and preparation method thereof |
| CN115245529A (en) * | 2021-04-26 | 2022-10-28 | 上海幼官健康管理有限公司 | A kind of skin penetrant and external pain reliever prepared therefrom |
| CN113398136A (en) * | 2021-07-23 | 2021-09-17 | 孟庆峰 | Ointment for relaxing tendons and activating collaterals and preparation method thereof |
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