JP6095857B2 - ピラゾロピリミジン化合物 - Google Patents

ピラゾロピリミジン化合物 Download PDF

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Publication number: JP6095857B2
Authority: JP; Japan
Prior art keywords: cancer; mmol; compounds; etoac; cell
Prior art date: 2013-11-15
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Active

Application number

JP2016530227A

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English (en)

Japanese (ja)

Other versions

JP2016537354A (ja

Inventor

ラウファー，ラドスロー

エン，グレース

リー，セー−ワン

ダブリュ．ポールズ，ハインズ

リウ，ヨン

クマールビー．パテル，ナレンドラ

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

University Health Network

Original Assignee

University Health Network

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-11-15

Filing date

2014-11-14

Publication date

2017-03-15

2013-11-15 Priority claimed from PCT/CA2013/000957 external-priority patent/WO2014075168A1/en

2014-11-14 Application filed by University Health Network filed Critical University Health Network

2016-12-01 Publication of JP2016537354A publication Critical patent/JP2016537354A/ja

2017-03-15 Application granted granted Critical

2017-03-15 Publication of JP6095857B2 publication Critical patent/JP6095857B2/ja

Status Active legal-status Critical Current

2034-11-14 Anticipated expiration legal-status Critical

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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

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Publication	Publication Date	Title
US10167289B2 (en)	2019-01-01	Pyrazolopyrimidine compounds
US11939320B2 (en)	2024-03-26	Modulators of the integrated stress pathway
US20230192712A1 (en)	2023-06-22	Modulators of the integrated stress pathway
US20140051679A1 (en)	2014-02-20	Kinase inhibitors and method of treating cancer with same
WO2011123937A1 (en)	2011-10-13	Kinase inhibitors and method of treating cancer with same
JP2010520220A (ja)	2010-06-10	インデノイソキノリノン類似体およびその使用方法
WO2022197641A1 (en)	2022-09-22	1h-pyrazolo[3,4-d]pyrimidin-6-yl-amine derivatives as hematopoietic progenitor kinase 1 (hpk1) modulators and/or inhibitors for the treatment of cancer and other diseases
US8980934B2 (en)	2015-03-17	Kinase inhibitors and method of treating cancer with same
KR102353441B1 (ko)	2022-01-19	피라졸로피리미딘 화합물
JP6095857B2 (ja)	2017-03-15	ピラゾロピリミジン化合物
US20050272766A1 (en)	2005-12-08	1-Glyoxylamide indolizines for treating lung and ovarian cancer

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