JP2659914B2 - Automatic priming method and apparatus for blood purification circuit - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method for automatically priming a blood purification circuit (extracorporeal blood circulation circuit) including a blood purifier (dialyzer, plasma separator, blood purification adsorber, etc.). Related to the device.

[0002]

2. Description of the Related Art Generally, a blood purification circuit is used each time a priming process is performed, that is, a priming liquid (generally, a physiological saline solution) is introduced into the circuit to remove foreign matter and air from the circuit. Processing, has been implemented.

That is, in this kind of priming processing method and processing apparatus, for example, FIG.
No. 9076), basically, the blood pump 1 is sequentially transferred from the arterial blood collection unit 10 to the venous blood return unit 12.
4. A blood purification circuit 22 in which an inlet drip chamber 16, a blood purifier 18, and an outlet drip chamber 20 are arranged, and the blood collection and blood return portions 10, 12 (connectors 10a, 12a) are connected to a circulation circuit. 24 and the upstream venous circuit portion 24a of the blood pump 14.
Is connected to a priming liquid supply system 26 composed of a storage container 26a and a supply pipe 26b, and an overflow system 28 is connected to the outlet drip chamber 20. In this case, the priming liquid supply system 26 is provided with a liquid shortage detector 30 and a flow control valve 32 for the priming liquid in the storage container 26a,
The overflow system 28 is provided with a clamp means 34, and further provided with a clamp means 36 on the downstream side of the circulation circuit of the outlet drip chamber 20. Then, the liquid shortage detector 30, both clamping means 34 and 36, and the blood pump 1
4 is controlled via the operation control unit 38 to perform a predetermined priming operation.

Accordingly, in such a processing method and / or processing apparatus (hereinafter, referred to as a prior art), when the blood pump 14 is driven with both clamp means 34 and 36 opened, the circulation circuit 24 A mixed liquid of the liquid retained in the circuit 24 and the priming liquid supplied from the priming liquid supply system 26 is circulated, and the mixed liquid corresponding to the supplied priming liquid is discharged from the overflow system 28. Therefore, according to the above-mentioned prior art, the cleaning (mixing) liquid circulating in the circulation circuit increases for a certain amount of the priming liquid. In this case, the increase amount of the cleaning liquid can be arbitrarily adjusted by adjusting the priming liquid replenishment amount through the flow rate adjustment valve 32, so that the priming effect (the efficiency of removing foreign matters and air in the circulation circuit) is reduced. Clearly, it can be improved. In this case, the priming process (step) is completed (stopped) when the detector 30 detects that the priming solution has run out.

[0005]

However, in the above-mentioned prior art, as described below, there is still a problem to be improved.

[0006] That is, the above-mentioned prior art employs a circulation circuit
In contrast, the priming effect is improved by circulating a mixture of the staying liquid and the replenishing priming liquid in the circuit 24. However, in the circulation processing step using the mixed liquid, each circuit portion 24a,
The flow direction of the liquid in the priming liquid supply system 26b, the priming liquid supply system 26, and the overflow system 28 is all limited to one direction indicated by an arrow. For this reason, in the prior art, particularly in the vein side circuit portion 24a between the outlet side drip chamber 20 and the connection point 40 of the priming liquid supply system 26, first, the air is effectively removed due to the long downward piping therebetween. The foreign matter (dust, chemicals, etc.) that is not performed and exists during this time is removed from the arterial circuit portion 24b.
This easily adheres to the arterial circuit portion 24b and the blood purifier 18, so that the cleaning effect cannot be sufficiently exerted. In addition, regarding the washing, a method of overflowing a part of the priming solution contaminated during circulation with a limited amount of a new clean priming solution while replenishing the priming solution with a limited amount, not only the vein side circuit portion 24a but also the vein side circuit portion 24a. Full circulation circuit 2 including arterial side circuit portion 24b
In No. 4, the cleaning effect was limited. Further, in the conventional technique, two control clamp means 34,
Because of the necessity of 36, there is also a disadvantage that the configuration is relatively complicated and expensive.

SUMMARY OF THE INVENTION An object of the present invention is to provide a method and an apparatus for automatically priming a blood purification circuit, which can achieve a priming effect sufficiently and can be configured relatively easily.

[0008]

In order to achieve the above object,
Therefore, a method for automatically priming a blood purification circuit according to the present invention includes a blood purification circuit including a blood pump and a blood purifier.
An arterial blood collection section and a venous blood return section are provided at both ends of the tract.
Circuit connecting the arterial blood collection unit and the venous blood return unit
And arrange a blood pump upstream of the blood purifier
Between the blood pump and the arterial blood collection unit.
The blood purifier and the venous blood return section.
An opening / closing means is provided between the blood purifier and the opening / closing hand.
Overflow that can be drained by the overflow method between the stage
-By driving the blood pump with a flow system
Priming liquid can be filled in the blood purification circuit
In the method for automatically priming the blood purification circuit, the priming liquid from the priming liquid supply system to the circulation circuit from the upstream vein side circuit portion of the blood pump to the overflow system using its own head. A venous washing and discharging step of flowing, and an arterial side of flowing the priming liquid from the priming liquid supply system from the downstream arterial circuit portion of the blood pump to the overflow system by utilizing its own head and the discharge pressure of the blood pump. It is characterized in that a washing / discharging step and an overall washing / circulating step of circulating the liquid retained in the circulation circuit through the entire circulation circuit by the discharge pressure of the blood pump after the both steps are performed .

[0009] In this case, the vein-side washing and discharging step is performed.
A process to execute the pulse side cleaning discharge step and the entire cleaning circulation step
After the completion of the liming process, a vein-side washing / discharging step and / or an arterial-side washing / discharging step are further performed.
It is possible that. Further, the vein-side cleaning discharging step and
After arterial side washing discharge step, dissipate continued across cleaning circulation process, and then the arterial washing discharging step
The entire washing and circulating step may be performed once or a plurality of times. Furthermore, in the entire cleaning circulation process, to the retentate in the circulation circuit, it may also be implemented to replenish part of the priming liquid from the priming liquid supply system.

[0010] Further, as an apparatus for performing the method for automatically priming the blood purification circuit, a blood pump and a blood pump are provided.
An arterial blood collection unit at both ends of a blood purification circuit including a purifier;
A venous blood return section is provided.
Connect the blood return section to form a circulation circuit, and
Place the blood pump on the flow side and operate with this blood pump.
Connect the priming fluid supply system between the
When opening / closing means is provided between the liquid purifier and the venous blood return section,
The overflow between the blood purifier and the opening / closing means.
An overflow system capable of draining liquid by the method
By driving the liquid pump,
The blood purification circuit that can be filled with
In the dynamic priming processing apparatus, a priming liquid supply system is provided with a liquid out detector and a clamp means,
Open downstream of the drip chamber on the outlet side of the blood purification circuit.
For example, a clamp means is provided as a closing means , and further, the liquid-out detector, both the clamp means and the blood pump,
In the blood purification circuit, a vein-side washing / discharging step in which the priming liquid from the priming liquid supply system flows from the upstream vein-side circuit portion of the blood pump to the overflow system by utilizing a head of the priming liquid supply system, and the artery side cleaning discharge step of flowing from the downstream artery side circuit portion of the blood pump to the overflow system priming liquid by utilizing the discharge pressure of its own drop and blood pumps from the circulation circuit after the both steps And a control means for performing a control operation for performing a processing step including a whole cleaning and circulating step of circulating the accumulated liquid through the entire circulation circuit by the discharge pressure of the blood pump.

[0011] In this case, it is preferable that the inlet side drip chamber and the blood purifier are arranged in the upward pipe portion of the circulation circuit.

[0012]

According to the present invention, a blood purification circuit is provided in a vein side circuit section.
And thereby forming a circulation circuit composed of the arterial side circuit section, with respect to priming apparatus connected the priming solution supply system and an overflow system to the circulation circuit,
The priming liquid supply system has a liquid shortage detector and opening / closing means
And to example both Ru provided clamping means, on the downstream side of the predetermined position, i.e. the outlet side drip chamber of the circulation circuit, by providing, for example, clamping means as closing means, to said circulation circuit, the venous washing discharge step, arterial Each processing step including the side cleaning discharge step and the entire cleaning circulation step can be implemented in an appropriate combination.

Therefore, in the present invention, first, the venous side circuit portion passes the priming solution from the priming solution supply system in the venous side washing / discharging step to the overflow system through the venous side circuit portion by its own head. It is clear that by flowing directly and upwardly, good air bleeding and a sufficient cleaning effect can be achieved. Next, the arterial side circuit portion directly flows the priming liquid from the priming liquid supply system through the arterial side circuit portion by its own head and the discharge pressure of the blood pump in the arterial side washing and discharging step, and directly to the overflow system. By letting
It is clear that a sufficient cleaning effect can be achieved. If air and foreign matter remain in both circuit parts on the venous and arterial sides, that is, in the entire circulating circuit, the liquid retained in the circulating circuit is removed by the discharge pressure of the blood pump in the entire washing and circulating step, and the entire circuit is circulated. And it can be integrated at a predetermined position in the circuit, that is, at the outlet drip chamber. Then, in the artery-side washing / discharging step to be performed next, the fluid can be smoothly discharged to the overflow system.

[0014]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Next, an automatic priming method for a blood purification circuit according to the present invention will be described in detail with reference to the accompanying drawings in relation to an apparatus for performing the method. For convenience of description, the same components as those of the conventional structure shown in FIG. 3 are denoted by the same reference numerals, and detailed description is omitted.

In FIG. 1, first, the basic configuration of the automatic priming processing apparatus of the present invention is the same as that of the conventional processing apparatus (FIG. 3). Therefore, the description will be briefly repeated again for the sake of easy understanding. That is, the arterial blood collection unit 1
0 to the venous blood return unit 12, blood collection and return to a blood purification circuit 22 in which a blood pump 14, an inlet drip chamber 16, a blood purifier (for example, a dialyzer) 18 and an outlet drip chamber 20 are arranged. The circulation parts 24 are formed by connecting the blood parts 10, 12 (connectors 10a, 12a). Next, in the upstream vein side circuit portion 24a of the blood pump 14, the storage container 26a and the supply pipe 2 are provided.
A priming liquid supply system 26 composed of 6b is connected, and an overflow system 28 is connected to the outlet drip chamber 20.

[0016] However, in the present invention, in the structure, the priming liquid supply system 26, the reservoir 26
out of liquid detector 50 for the priming liquid in a
Rutotomoni clamping means 52 as an opening and closing means provided on the downstream side of the circulation circuit on the outlet side drip chamber 20, open
A clamping means 54 as a closing means is provided. Then, the liquid-out detector 50, the two clamping means 52, 54, and the blood pump 14 are configured to perform a predetermined priming operation via the operation control unit 56, respectively. The inlet drip chamber 16 and the blood purifier 18
Are arranged in the upward pipe portion, and are formed so as to make the downward pipe portion as short as possible by forming steps. This is to improve the priming effect by increasing the ability to discharge air and foreign substances, as described later.

Therefore, according to the present invention, in the above configuration, the venous washing and discharging step (first type processing step), the arterial washing and discharging step (second type processing step) and the entire washing and circulation are performed on the circulation circuit 24. Each processing step including a step (third type processing step) is performed sequentially and appropriately in combination. That is, referring also to FIG. 2, first, a standby processing step is performed in step 0, a first type processing step is performed in step 1, and a second type processing step is performed in step 2.
Thereafter, a third type processing step is performed in step 3, a second type processing step is performed again in step 4, and if necessary, the processing step (third type) is performed again in step 5.
(Seed-second kind) or the repetition thereof, and finally a completion (stop) processing step is performed in Step 6.

In this case, step 0 (standby processing step)
Is activated by inputting a standby switch (not shown) of the operation control unit 56. In this state, FIG.
As shown in (5), the other components are kept inactive (open or stopped) except for the operation (close) of the clamp means 52 of the priming liquid supply system 26. And there is no liquid flow in each part. After that, in the above state, the priming switch (not shown) of the operation control unit 56 is input (manually or automatically), so that each of the aforementioned subsequent steps 1
To 6 are sequentially and automatically performed.

That is, when step 1 (venous side washing / discharging step) is activated, the priming liquid from the priming liquid supply system 26 itself is opened by opening the clamping means 52 of the priming liquid supply system 26. At the head of
The fluid is discharged from the connection point 40 to the overflow system 28 through the venous circuit portion 24a (and the connectors 10a, 12a and the outlet drip chamber 20 therebetween). However, at this time, the priming liquid flows directly and upward (indicated by an asterisk) in the vein side circuit portion 24a, so that air bleeding and washing of the vein side circuit portion 24a can be sufficiently and sufficiently achieved. it is obvious.

Next, after a predetermined time has elapsed, when step 2 (the artery-side washing and discharging step) is activated, the vein-side circuit portion 24 is activated.
a when the clamping means 54 of FIG.
4 is operated in a predetermined state, and the priming liquid from the priming liquid supply system 26 is moved from the connection point 40 to the arterial circuit portion 2 by its own head and the discharge pressure of the blood pump 14.
4b (and the inlet side drip chamber 16 and the blood purifier 18 therebetween), and is discharged to the overflow system 28. However, at this time, the priming fluid flows directly in the arterial circuit portion 24b,
Since the drip chamber 16 and the blood purifier 18 are arranged in the upwardly-facing pipe step as short as possible, the ability to discharge air and foreign substances is increased as described above. Therefore, it is clear that air bleeding and cleaning of the arterial circuit portion 24b can be satisfactorily and sufficiently achieved.

As described above, in the present invention, the priming process in the steps 1 and 2 can be almost completely achieved, but the following processing steps can be performed to further improve the effect. That is, after that, step 3
When the (entire washing and circulating step) is activated, the clamping means 54 of the venous circuit portion 24a is opened, and the clamping means 52 of the priming liquid supply system 26 is closed, so that the priming stays in the circulation circuit 24. The liquid circulates in this circuit 24 at the discharge pressure of the blood pump 14. Thus, if air and debris still remain in the circuit 24, these residues will eventually collect in the outlet drip chamber 20. At this time, the blood pump 14
When the high speed / stop operation is repeatedly performed, the accumulation effect can be enhanced. In this step 3,
By simultaneously opening the clamping means 52 of the priming liquid supply system 26 together with the clamping means 54 of the vein side circuit portion 24a, a fresh priming liquid for the staying priming liquid is partially removed from the priming liquid supply system 26. It can also be configured to replenish.

Thereafter, when the step 4 is activated, the clamping means 54 of the vein side circuit portion 24a is closed and the clamping means 52 of the priming liquid supply system 26 is opened, so that the processing step is performed again on the artery side. The process returns to the cleaning / discharging step (step 2).
Not only the residue (chemicals such as dust and glycerin) accumulated in the inside, but also the residue contained in the entire circuit to be cleaned is discharged from the overflow system 28. Further, if necessary, in step 5, the above-mentioned processing step (third type) or its repetition (second type to third type)
It is clear that the priming effect can be further improved by implementing (seeds). This means that
Metaphorically speaking, squeezing and rinsing rather than rinsing during washing is the same as increasing the washing efficiency per unit wash water.

In step 4, the process is returned to step 1 (venous side washing / discharging step). Then, if necessary, in step 5, the above-described processing steps (third type or second type to second type) are performed again. 3 types) or its repetition (1st type ~
It is clear that the priming effect can be improved by implementing the third type or the first to second types to the third type).

Finally, step 6 (completion stopping step)
Is activated, and when the liquid shortage detector 50 detects the liquid shortage of the priming liquid in the storage container 26a, the venous circuit portion 2
When the clamping means 54a of FIG. 4a is opened and the clamping means 52 of the priming liquid supply system 26 is closed, the processing step returns to the overall cleaning and circulating step (step 3). In this state, the priming processing is started. Complete (stop).

When the priming process is completed (stopped), the flow rate of the priming solution is calculated and integrated based on, for example, an operation signal of the blood pump 14 without using the liquid shortage detector 50. However, when a predetermined amount of the priming solution is supplied, the priming process may be completed (stopped) in the same manner as described above.

As described above, according to the present invention, the entire circulation circuit (blood purification circuit), particularly the venous circuit portion thereof, can exhibit good air bleeding and cleaning functions.
A sufficient priming effect can be achieved. Furthermore, in the present invention, the overflow system does not require a clamp means, and the clamp for the vein side circuit portion can use the air bubble detector interlocking clamp normally provided in the blood purification apparatus as it is. This has the advantage that it can be constructed relatively simply and inexpensively.

The preferred embodiment of the present invention has been described above. However, the present invention is not limited to the above-described embodiment, and many design changes can be made without departing from the spirit of the present invention.

[0028]

As described above, the method and apparatus for automatically priming a blood purification circuit according to the present invention form a blood purification circuit in a circulating circuit comprising a venous circuit portion and an arterial circuit portion. this circulation circuit priming liquid supply system and the overflow system relative priming device connected, the priming liquid supply system provided with clamping means as solution break detector and closing means Rutotomoni, predetermined position or outlet of the circulation circuit By providing clamping means as opening and closing means on the downstream side of the side drip chamber,
Venous washing discharge step, each processing step including arterial washing discharging process and the whole cleaning circulation process, if configured to performed in combination sequentially and appropriately processes respectively, a vein side circuit portion, the venous washed discharged Uses the head of the priming liquid from the priming liquid supply system in the process
Then , it can be flowed directly and upward through the venous circuit part to the overflow system to achieve good air bleeding and a sufficient washing effect, and the arterial side circuit part can be used in the arterial washing and discharging step. The priming liquid from the priming liquid supply system flows directly through the arterial side circuit portion to the overflow system using the head of the priming liquid and the discharge pressure of the blood pump, thereby achieving a sufficient cleaning effect. Incidentally, even if in air and foreign matter remaining in the circulation circuit, venous washed discharging process continues the entire washing circulation step and to and /
Alternatively, in the arterial washing / discharging step, it can be properly discharged to the overflow system.

Therefore, according to the present invention, a sufficient priming effect can be achieved for the entire circulation circuit (blood purification circuit), particularly for the vein side circuit portion. Further, according to the present invention, the overflow system does not require any clamp means, and the clamp for the vein side circuit portion can use the air bubble detector interlocking clamp usually provided in the blood purification apparatus as it is. Therefore, there is an advantage that the configuration can be made relatively easily and inexpensively.

[Brief description of the drawings]

FIG. 1 is a system diagram showing one embodiment of an automatic priming processing device for a blood purification circuit according to the present invention.

FIG. 2 is a process explanatory view showing an automatic priming process operation in the processing apparatus shown in FIG. 1;

FIG. 3 is a system diagram showing a conventional automatic priming device for a blood purification circuit.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 10 Arterial side blood collection part 12 Static artery side blood collection part 10a Blood collection side connector 12a Blood return side connector 14 Blood pump 16 Inlet drip chamber 18 Blood purifier 20 Outlet drip chamber 22 Blood purification circuit 24 Circulation circuit 24a Vein side circuit part 24b Arterial-side circuit part 26 Priming liquid supply system 26a Storage container 26b Supply pipe 28 Overflow system 40 Connection point 50 Liquid out detector 52 Supply pipe clamp means 54 Venous circuit part clamp means 56 Operation control unit

Claims (6)

(57) [Claims] 1. A blood having a blood pump and a blood purifier.
An arterial blood collection section and a venous blood return section are provided at both ends of the purification circuit.
Connection between the arterial blood collection unit and the venous blood return unit
Configure a circulation circuit and install a blood pump upstream of the blood purifier.
And place it between this blood pump and the arterial blood collection unit.
Connect the priming solution supply system, blood purifier and venous
Opening and closing means is provided between the blood purifier and the blood purifier.
Drainable by overflow method between opening and closing means
Drive the blood pump by providing a simple overflow system
Priming liquid can be filled in the blood purification circuit
In <br/> method configured to ability to automatically priming a blood purification circuit, upstream venous circuit of the priming fluid by utilizing the difference of its own blood pump from priming liquid supply system to the circulation circuit A venous washing and draining step of flowing the priming fluid from the priming fluid supply system to the overflow system from the downstream arterial circuit portion of the blood pump utilizing its own head and the discharge pressure of the blood pump. An arterial washing / discharging step of flowing to the system, and a blood washing / circulating step of circulating the liquid retained in the circulation circuit through the entire circulation circuit by the discharge pressure of the blood pump after the both steps. Automatic priming treatment method for purification circuit. 2. A vein-side washing and discharging step, and an arterial-side washing and discharging.
Process and a priming process for performing the entire cleaning and circulating process.
2. The method according to claim 1, further comprising performing a venous washing and discharging step and / or an arterial washing and discharging step after the completion of the treatment.
An automatic priming method for the blood purification circuit according to the above. After wherein the vein side washing discharge step and artery side cleaning discharge step, further with continuing the entire washing circulation step, followed by the arterial cleaning discharging process and the whole cleaning circulation
3. The method according to claim 2, wherein the steps are repeated one or more times. 4. In the entire cleaning and circulating step, a circulation circuit
2. The method for automatically priming a blood purification circuit according to claim 1, wherein the priming liquid is partially replenished from the priming liquid supply system to the retained liquid. 5. A blood comprising a blood pump and a blood purifier.
An arterial blood collection section and a venous blood return section are provided at both ends of the purification circuit.
Connection between the arterial blood collection unit and the venous blood return unit
Configure a circulation circuit and install a blood pump upstream of the blood purifier.
And place it between this blood pump and the arterial blood collection unit.
Connect the priming solution supply system, blood purifier and venous
Opening and closing means is provided between the blood purifier and the blood purifier.
Drainable by overflow method between opening and closing means
Drive the blood pump by providing a simple overflow system
Priming liquid can be filled in the blood purification circuit
In the automatic priming processing device for a blood purification circuit configured as described above, a priming liquid supply system is provided with a liquid shortage detector and a clamp means, and a clamp means is provided downstream of an outlet drip chamber of the blood purification circuit , For the out-of-liquid detector, both clamping means and blood pump,
In the blood purification circuit, a venous washing and discharging step in which the priming liquid from the priming liquid supply system flows from the upstream vein side circuit portion of the blood pump to the overflow system using the head of the priming liquid supply system, priming liquid by utilizing the discharge pressure of its own drop and blood pump and the arterial cleaning exhaust process from a downstream artery side circuit portion to flow into the overflow system of the blood pump, in the circulation circuit after the two steps of An automatic priming process for a blood purification circuit, comprising: a control means for performing a control operation for performing a processing step including a whole washing and circulating step of circulating a stagnant liquid through the entire circulation circuit by a discharge pressure of a blood pump. apparatus. 6. An inlet-side drip chamber and a blood purifier are arranged in an upward pipe portion of a circulation circuit.
An automatic priming processing device for a blood purification circuit according to the above.