JP2024145786A - Cleansing compositions and methods for producing same - Google Patents

Abstract

To provide a composition for a clean, disinfection, moisturization, and pleasant smell.SOLUTION: The cleansing composition is a mixture of 0.001 wt.% to 50 wt.% of coumaric acid methyl ester, 0.001 wt.% to 75 wt.% of a bactericidal component, and 0.001 wt.% to 50 wt.% of a moisturizing component, excluding water. Furthermore, 0.001 wt.% to 50 wt.% of coumarin is mixed in. The above-mentioned coumaric acid methyl ester and/or coumarin are extracted by finely cutting or powdering Cerasus speciosa, Cerasus jamasakura, Prunus yedoensis, Cerasus serrulata, or Prunus campanulata and mixing them with alcohol, water, oil, ether, or carbon tetrachloride.SELECTED DRAWING: Figure 1

Description

Application for exception to loss of novelty has been filed

The present invention relates to a cleansing composition (cleaning composition/cleaning agent/external agent) and a method for producing the same, and in particular to a cleansing composition that removes dirt and cleanses the external surfaces of the body, such as the skin, body hair, and scalp, and a method for producing the same.

Traditionally, a wide variety of such cleansing compositions have been considered, including cleansing alcohol, topical alcohol, soap, shampoo, and disinfectant alcohol. Accordingly, various methods for producing them have also been considered.

JP 2022-007803 A Special Publication No. 2008-501759 Japanese Patent Application Publication No. 7-258074 JP 2001-245688 A Special Publication No. 2005-529973 JP 2003-155225 A Japanese Unexamined Patent Publication No. 57-75937 JP 2016-88910 A Japanese Patent Application Publication No. 199795/1983 Special Publication No. 10-513189 JP 2016-041660 A Special Publication No. 09-511244 JP 2004-026657 A JP 2007-056009 A Patent No. 6651104 Chinese Patent Publication No. 103705391 JP 2013-170163 A

The present invention has been made to solve the above-mentioned problems, and the object of the present invention is to provide a cleansing composition and a method for producing the same that can achieve optimal conditions for cleaning, wiping, washing, disinfecting, etc. of the external surface of the body, compared to conventional cleansing compositions, etc.

For this reason, the cleansing composition of the present invention is a nearly uniform mixture of 0.001% to 50% by weight of coumaric acid methyl ester or/and coumarin, 0.001% to 75% by weight of a bactericidal component, and 0.001% to 50% by weight of a moisturizing component, excluding water, with the total amount not exceeding 100% by weight.

The above coumaric acid methyl ester/coumarin was extracted from Oshima cherry, Yamazakura cherry, Somei-Yoshino cherry, Satozakura cherry or Higanzakura cherry.

As a result, dirt can be removed, cleaned or disinfected from the outside of the body by simply wiping it with this cleaning composition without first cleaning it, and it leaves a pleasant scent. Of course, you can also wipe it with this cleaning composition after washing. Since it does not contain any deodorant ingredients, the emitted fragrance will not disappear. In addition, the germicidal action prevents the growth of microorganisms that emit odors, smells, and scents other than the fragrance in question, so the fragrance will not deteriorate.

When this cleansing composition is applied to the skin, it does not make the skin too moist or too dry, nor does it have too much or too little oil, but rather provides just the right amount of moisture and oil, and has a clean scent. In addition, this cleansing composition/coumaric acid methyl ester/coumarin also has anti-inflammatory effects, pressure ulcer prevention effects, pressure ulcer improvement effects, and antibacterial virus effects, making it useful for preventing and treating infectious diseases.

1 shows the decrease in nitric oxide (NO) in mouse monocytic leukemia RAW264.7 cells by increasing the amount of coumaric acid methyl ester added. 1 shows the suppression of IL-6 mRNA expression in mouse monocytic leukemia RAW264.7 cells by increasing the amount of methyl coumarate added. 1 shows the suppression of iNOS mRNA expression in mouse monocytic leukemia RAW264.7 cells by increasing the amount of methyl coumarate added. 1 shows the suppression of IL-1β mRNA expression in mouse monocytic leukemia RAW264.7 cells by increasing the amount of methyl coumarate added. It shows that the elimination rate of DPPH gradually improves with increasing amount of methyl coumarate added.

(1) Cleaning compositions for wiping items, etc. (coumaric acid methyl ester, coumarin)
This cleaning composition can be applied to tissue paper, towels, handkerchiefs, cloth, masks, gloves, protective clothing, protective hats, and other cleaning materials and personal clothing, and can be used to clean dirty hands, feet, face, arms, legs, torso, neck, head, armpits, pubic area, buttocks, and other parts of a person requiring care, simply by wiping them.

The water may be soft water, hard water, tap water, or distilled water, and 10% to 500% by weight of the water is mixed almost uniformly into the cleaning composition such as a skin wipe, etc., per 1% by weight of the cleaning composition, and optionally emulsified. The above cleaning composition contains 0.001% to 50% by weight of coumaric acid methyl ester or/and coumarin, excluding water, in a range not exceeding 100% by weight of the total cleaning composition, and is mixed almost uniformly into the cleaning composition such as a wipe, etc., and optionally emulsified.

Coumaric acid methyl ester and coumarin are found in Oshima cherry, Yamazakura, Somei Yoshino, Satozakura, Higanzakura, etc., and the leaves, flowers, stems, fruits, bark and trunks of Oshima cherry, Yamazakura, Somei Yoshino, Satozakura and Higanzakura are used as is or cut into small pieces, and in some cases made into powder form, and mixed with alcohol, for example butylene glycol (1,3-butylene glycol). Note that coumaric acid methyl ester and coumarin are found in the highest amounts in the leaves and flowers mentioned above.

After a while at room temperature or when heated, coumaric acid methyl ester and coumarin will dissolve into the alcohol. After this, the alcohol can be evaporated or left as is to obtain coumaric acid methyl ester and coumarin or coumaric acid methyl ester and coumarin with alcohol. In this way, coumaric acid methyl ester and coumarin are extracted and produced. This coumaric acid methyl ester and coumarin gives off an aromatic smell.

The alcohol may be butylene glycol (1,3-butylene glycol), dipropylene glycol, glycerin, ethyl alcohol, methyl alcohol, etc. Also, in place of the alcohol, a solvent such as water, oil, ether, or carbon tetrachloride may be used in whole or in part.

The above-mentioned Oshimazakura is a type of cherry tree that grows wild on the Izu Seven Islands. It is cultivated in various places due to its pale red new leaves and large, beautiful white flowers, and is considered to be one parent of Somei-Yoshino. The above-mentioned Yamazakura, Somei-Yoshino, Satozakura, and Higanzakura are part of the deciduous tall trees or shrubs of the genus Prunus in the family Rosaceae, which excludes plums, peaches, and apricots.

Although there are several species of these cherry trees in mainland China and the Himalayas, Japan has the greatest variety, with a large number of horticultural varieties, which bloom in spring in white and pale pink to deep red flowers, and some varieties have double blossoms. Since ancient times, they have been called the King of Flowers and are the national flower of Japan, and in the past, "flower" meant the cherry blossom. The wood is homogenous and is used for equipment and shipbuilding, and has long been considered ideal for woodblock printing. The bark is used for cough medicine (sakurakawajin) and to make bent objects and other items, salted flowers are used for sakurayu, salted leaves are used for sakura mochi, and the fruit of the cherries is edible.

When such a cleaning composition containing coumaric acid methyl ester, coumarin, etc. is soaked into tissue paper, handkerchiefs, towels, pulp, paper, cloth, resin, etc. and used to wipe the dirty hands, feet, face, arms, legs, torso, neck, head, abdomen, chest, back, armpits, genitals, buttocks, private parts, etc. of people requiring care, the elderly, people with disabilities, infants, small children, etc., sebum stains, feces and urine, excrement, vomit, unwanted dirt on the skin, and other dirt are wiped away cleanly and easily, providing excellent cleaning properties, cleaning, disinfecting, moisturizing, and protecting the skin, and giving off a pleasant scent. Furthermore, the cleaning composition can be used to keep healthy people clean during disasters, emergencies, peacetime, etc.

As a result, the skin's moisture, elasticity, moistness, and smoothness are maintained, it does not damage the skin, it is hypoallergenic, and it prevents dry skin in winter and other seasons, thus protecting the skin. In this respect, it differs from rubbing alcohol, bleach, etc. In addition to the skin, it can also be used on mucous membranes, nails, hair, body hair, inside the mouth, etc., and it can also be used on animals other than humans, and it can be used externally or internally.

(2) Coumaric acid methyl ester The above-mentioned coumaric acid methyl ester has the chemical formula CHO and a structure shown in Chemical Formula 1. This coumaric acid methyl ester has the following chemical properties.

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

This coumaric acid methyl ester inhibits the production of NO (nitric oxide) by LPS (an inflammatory inducer), inhibits the expression of mRNA for the inflammatory genes iNOS (inducible nitric oxide synthase), IL-6 (interleukin-6), and IL-1β (interleukin-1β), and has anti-inflammatory activity at the cellular level. It also has an antioxidant effect. It also improves the elimination rate of DPPH.

The above-mentioned iNOS is an enzyme that synthesizes nitric oxide from L-arginine. The above-mentioned IL: interleukin is a general term for peptides and proteins secreted by lymphocytes and macrophages primarily to regulate immune responses, and the above-mentioned "-6" and "-1β" are symbols that distinguish each peptide and protein. The above-mentioned DPPH (diphenyl-1-picrylhydrazyl) is a radical.

In addition to the above production method, this coumaric acid methyl ester can also be produced/produced as follows: diisopropylethylamine is added to a suspension of coumaric acid (115.5 g) in N-methylpyrrolidone (600 mL) at 25°C, dimethyl sulfate (100.9 g) is added over 1 hour, and the reaction mixture is stirred at 25°C for 2 hours.

The reaction mixture is then diluted with toluene and extracted with water, then bicarbonate, and finally with water. The toluene is removed under vacuum, and the crude pyrone ester is purified by short path distillation or crystallization and trituration to produce 78.8 g of coumaric acid methyl ester, 99% pure, 64% yield, after removal of residual solvent by evaporation under vacuum. The coumaric acid methyl ester has an aromatic odor.

(3) p-Coumaric acid methyl ester The above-mentioned p-coumaric acid methyl ester (trans-p-coumaric acid methyl ester) is included in the above-mentioned coumaric acid methyl ester, has the chemical formula CHO and a structure represented by "Chemical formula 2," and this p-coumaric acid methyl ester has the following chemical properties.

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

This p-coumaric acid methyl ester inhibits the production of NO (nitric oxide) by LPS (an inflammation-inducing substance), inhibits the expression of mRNA for inflammation-inducing genes iNOS (inducible nitric oxide synthase), IL-6 (interleukin-6), and IL-1β (interleukin-1β), and has anti-inflammatory activity at the cellular level. It also has an antioxidant effect. It also improves the elimination rate of DPPH.

In addition to the above production method, this p-coumaric acid methyl ester can also be produced/generated as follows. Dissolve 30 mg of commercially available p-coumaric acid in 3 ml of methanol. Separately, add 10% aqueous potassium hydroxide solution to p-toluenesulfonyl-N-methyl-N-nitrosamide and heat to generate diazomethane, which is passed through ether to obtain a diazomethane/ether solution.

An appropriate amount of this diazomethane/ether solution is added to the above methanol solution of p-coumaric acid while checking with silica gel thin layer chromatography (chloroform/methanol = 10:1), and then concentrated to dryness under reduced pressure. The residue is separated and purified by preparative silica gel thin layer chromatography (separation liquid: chloroform/methanol mixture = 10:1), and 27 mg of p-coumaric acid methyl ester is produced. This p-coumaric acid methyl ester gives off an aromatic odor.

The coumaric acid methyl ester compound can also be produced/purified as follows: A solution of the pyrone ester (39 g, 95% purity) in acetic acid is added over 3.5 hours to a refluxing solution of pyridinium tribromide (105 g) in glacial acetic acid (233 g). The mixture is refluxed (85°C → 107°C) for 3 hours and then cooled to ambient temperature. Water is added and the crude product is isolated by filtration and washed with water. The crude product is purified by recrystallization from toluene and isohexane to give 3-bromocoumaric acid methyl ester (46 g, 82% yield).

In addition to the above-mentioned coumaric acid methyl ester, coumaric acid methyl ester also includes p-coumaric acid methyl ester, o-coumaric acid methyl ester, m-coumaric acid methyl ester, and the like. In this application, all of these are collectively referred to as "coumaric acid methyl ester."

(4) Coumarin The above-mentioned coumarin has the chemical formula C9H6O2 and the structure shown in "Chemical Formula 3." This coumarin has the following chemical properties.

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

This coumarin inhibits the production of NO (nitric oxide) by LPS (an inflammatory inducer), inhibits the expression of mRNA for the inflammatory genes iNOS (inducible nitric oxide synthase), IL-6 (interleukin-6), and IL-1β (interleukin-1β), and has anti-inflammatory activity at the cellular level. It also has antioxidant properties. It also improves the elimination rate of DPPH.

In addition to the above production method, this coumarin can also be produced/generated in the following way. In living leaves, it is bound to sugar molecules in the form of coumaric acid (o-coumaric acid) glycoside and isolated in the vacuole, so it does not have an odor. When leaves or flowers of Oshima cherry, Yamazakura, Somei-Yoshino, Satozakura, Higanzakura, other cherry trees, and Eupatorium tuberosum, which contain this coumaric acid (o-coumaric acid) glycoside, are semi-dried, crushed, salted, etc., the coumaric acid glycoside in the vacuole comes into contact with enzymes outside the vacuole in dead cells, and coumaric acid is separated by hydrolysis, and a ring-closing reaction occurs to produce/produce coumarin. This coumarin gives off an odor.

In addition to the above production method, coumarin can also be produced/produced in the following way. It is synthesized by the Perkin reaction from salicylaldehyde, acetic anhydride, and sodium acetate.

In addition to the above production method, coumarin can also be produced/generated in the following way. Phenylalanine is converted to cinnamic acid by the catalytic action of an enzyme, which is then converted to o-coumaric acid (2-coumaric acid) by the catalytic action of the enzyme, which is then converted to β-D-glucosyl 2-coumaric acid by the catalytic action of the enzyme, which is then converted to β-D-glucosyl 2-coumaric acid by the catalytic action of the enzyme, which is then converted to 2-coumaric acid by the catalytic action of the enzyme, and coumarin is obtained by the catalytic action of the enzyme again. The hydroxyl group and carboxyl group at the 2-position form a lactone, which is an intramolecular ester, and then cyclized.

In addition to the above production method, this coumarin can also be produced/generated as follows: Take three samples of 0.1g each of Hamamatsu benzine extract, transfer them to a 50ml container, add an appropriate amount of ethanol, dissolve by ultrasound, cool, add a certain amount of ethanol and mix. Take 1ml and transfer it to a 10ml container, add a certain amount of 70% ethanol, mix, take 3ml and transfer it to a 25ml container. This 1g of Hamamatsu extract contains 10.2mg of coumarin. The absorbance is measured at a wavelength of 340nm to determine the coumarin content in the solution, and the coumarin content can be calculated from the amount of umbelliferone.

(5) Bactericidal component A bactericidal component is mixed almost uniformly in a sanitizing composition containing 0.001% to 50% by weight of the methyl coumarate ester, or in a sanitizing composition containing 0.001% to 50% by weight of the methyl coumarate ester mixed with coumarin, excluding water, in an amount of 0.001% to 75% by weight, not exceeding 100% by weight in total. The bactericidal component is one or more of sodium benzoate, benzalkonium chloride, iodopropynyl butylcarbamate, cymen-5-ol, and phenoxyethanol.

Sodium benzoate has the chemical formula C6H5COONa and the structure shown in Chemical Formula 4. This sodium benzoate has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。安息香酸ナトリウムは安息香酸Ｃ6Ｈ5ＣＯＯＨを水酸化ナトリウムＮａＯＨで中和して生成して生産される。このとき水Ｈ2Ｏも生成される。安息香酸ナトリウムは、市販もされている。安息香酸ナトリウムは殺菌作用、防腐作用を有する。

In addition, the numbers in the above and following chemical formulas are normally written in small letters at the bottom right of each chemical symbol, but in this application, they are written in normal half-width large size for ease of viewing. Sodium benzoate is produced by neutralizing benzoic acid, C6H5COOH, with sodium hydroxide, NaOH. Water, H2O, is also produced during this process. Sodium benzoate is also commercially available. Sodium benzoate has bactericidal and antiseptic properties.

Benzalkonium chloride has the structure shown in Chemical Formula 5, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。Ｒは炭素数１～５０を有する、例えば炭素数８～１８を有するアルキル基である。

In addition, the numbers in the above and following chemical formulas are normally written in small letters to the lower right of each chemical symbol, but in this application, they are written in normal large half-width size for ease of viewing. R is an alkyl group having 1 to 50 carbon atoms, for example, 8 to 18 carbon atoms.

Benzalkonium chloride has bactericidal and antiseptic properties, and is bactericidal against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Candida, and has particularly excellent bactericidal activity against bacteria. Benzalkonium chloride is commercially available.

Iodopropynyl butylcarbamate has the structure shown in Chemical Formula 6, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。ブチルカルバミン酸ヨウ化プロピニルは、市販もされている。ブチルカルバミン酸ヨウ化プロピニルは、殺菌作用、防腐作用、忌避作用を有する。

In addition, the numbers in the above and following chemical formulas are normally written in small letters at the bottom right of each chemical symbol, but in this application, they are written in normal half-width large letters for ease of viewing. Iodopropynyl butylcarbamate is also commercially available. Iodopropynyl butylcarbamate has bactericidal, antiseptic and repellent properties.

Cymen-5-ol (or o-cymen-5-ol) has the structure shown in Chemical formula 7, and this cymen-5-ol has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。シメン－５－オールは、市販もされている。シメン－５－オールは、殺菌作用を有する。

In addition, the numbers in the above and following chemical formulas are normally written in small letters at the bottom right of each chemical symbol, but in this application, they are written in normal half-width large letters for ease of viewing. Cymen-5-ol is also commercially available. Cymen-5-ol has a fungicidal effect.

Phenoxyethanol has the structure shown in Chemical Formula 8, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

Phenoxyethanol is produced by the hydroxyethylation of phenol (Williamson synthesis) in the presence of an alkali metal hydroxide or alkali metal borohydride. It is also available commercially. Phenoxyethanol has antiseptic, bactericidal, antifungal, insecticidal and disinfectant properties, and is particularly effective against gram-negative and gram-positive bacteria and Candida albicans.

(6) Moisturizing component: In a sanitizing composition containing 0.001% to 50% by weight of the above-mentioned methyl coumarate ester, or in some cases a mixture of this methyl coumarate and coumarin, excluding water, a bactericidal component is almost uniformly mixed in an amount of 0.001% to 75% by weight, not exceeding a total of 100% by weight, and/or a moisturizing component is almost uniformly mixed in an amount of 0.001% to 50% by weight, not exceeding a total of 100% by weight.

The moisturizing ingredient is one or more of the following: sodium hyaluronate, butylene glycol (1,3-butylene glycol), sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, and sodium dilauroyl glutamate lysine (pellicer).

Sodium hyaluronate has the structure shown in Chemical formula 9, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

Hyaluronic acid is isolated from the combs of the above birds and chickens, and is produced by reacting it with sodium hydroxide. Sodium hyaluronate is also produced by lactic acid bacteria. It is also available commercially. Sodium hyaluronate has a moisturizing effect.

Sodium hyaluronate has a large molecular weight, barely penetrates the skin, forms a moisture-containing film on the skin surface, prevents evaporation of moisture from the skin, maintains or replenishes moisture in the stratum corneum, maintains the flexibility of the stratum corneum, has a moisturizing effect by retaining moisture on the skin surface, has water retention properties, and is effective in preventing and/or improving rough skin.

Butylene glycol (1,3-butylene glycol) has the structure shown in Chemical formula 10, and this butylene glycol (1,3-butylene glycol) has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

Butylene glycol (1,3-butylene glycol) is hygroscopic and penetrates the stratum corneum of the skin, acting as an intermediary between keratin and water molecules, thereby exerting a moisturizing effect. In addition, at a concentration of about 7-10%, it exhibits specific antibacterial activity against gram-negative bacteria and has an antiseptic effect. Butylene glycol (1,3-butylene glycol) is commercially available.

Sodium lactate has the structure shown in Chemical formula 11, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

The above-mentioned sodium lactate is a lactate salt of sodium, a compound with the chemical formula C3H5NaO3, which is produced by neutralizing lactic acid produced by fermenting sugar. It is also available commercially. It is originally a liquid, but powdered preparations are also available commercially. It has antibacterial and moisturizing effects, and may improve the shelf life and flavor of many foods, including meat, and prevent water separation. Although it has the word "milk" in it, it is not an allergen for milk allergies. It has moisturizing properties.

The above-mentioned sodium lactate is produced by reacting the above-mentioned lactic acid with a sodium hydroxide solution or other sodium solutions. It is also commercially available. Sodium lactate is highly soluble in water, ethanol, and glycerin, but is insoluble in ether, chloroform, and oils and fats. A 50-60% aqueous solution is considered to have a wide range of applications, and has excellent moisturizing properties and emulsion stability. This sodium lactate can also be used as the above-mentioned bactericidal ingredient.

Potassium lactate has the structure shown in Chemical Formula 12, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

The potassium lactate is produced by fermenting sugar to produce lactic acid, then neutralizing this lactic acid. It is also commercially available. It has moisturizing and antibacterial properties. This potassium lactate can also be used as the above-mentioned bactericidal ingredient.

Lactic acid has the structure shown in Chemical Formula 13, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

The above-mentioned lactic acid is produced by fermenting various sugars such as molasses and starch as raw materials (fermentation method). Lactic acid can also be produced by reacting acetaldehyde with hydrogen cyanide to produce lactonitrile, which is then hydrolyzed by adding sulfuric acid and reacting with methanol to produce methyl lactate, which is purified and hydrolyzed to produce lactic acid (synthetic method). It is also commercially available.

Lactic acid, mentioned above, is an organic acid that is produced by breaking down sugar in the absence of oxygen, such as through lactic acid fermentation or intense muscle exercise. It is usually produced by fermenting glucose with lactic acid bacteria. It is a colorless, starch syrup-like substance that is sour and odorless, and is used industrially and as an acidifier in soft drinks, and also has a moisturizing effect.

Hyaluronic acid has the structure shown in Chemical Formula 14, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

Hyaluronic acid is isolated and produced from the combs of birds and chickens. It is also produced by lactic acid bacteria. Hyaluronic acid has a moisturizing effect. It is also commercially available.

The above-mentioned hyaluronic acid is a type of linear glycosaminoglycan (mucopolysaccharide), and is academically known as hyaluronan. It has high water retention and is viscous due to water retention, and is widely distributed in the body, playing an important role in skin, cartilage, and the eyeball. The molecular weight of hyaluronic acid can reach as high as 2 million, but is as low as 411.

Injections for osteoarthritis and adult cosmetic purposes have been approved by the FDA as a medical treatment, and it is added to cosmetics as a moisturizing ingredient to soothe discomfort in the knees and dry skin. For industrial production, hyaluronic acid is mainly isolated from rooster combs, and hyaluronic acid is also produced by lactic acid bacteria. For medical purposes, non-animal collagen is used, such as the brand Restylane.

Hyaluronic acid has a moisturizing effect on the skin surface. Because its molecular weight is extremely high, ranging from 800,000 to 1.2 million, it was thought that it would be difficult to absorb when applied topically, but by applying five types of hyaluronic acid with molecular weights ranging from 50,000 to 2 million, the moisture content and elasticity of the skin is improved more than when a placebo is used, regardless of the molecular weight. When the water retention of the epidermis decreases, fine wrinkles commonly known as "crepe wrinkles" appear, but moisturizing has the effect of preventing these fine wrinkles caused by dryness.

Because hyaluronic acid retains moisture and is hydrophilic, it could be processed to make it less likely to be repelled by sebum, and in a blind test, applying it to half of the face improved the moisture content and texture compared to the untreated side. A bubble solution using lotion containing hyaluronic acid could also be considered, taking advantage of the water-retaining power and high viscosity of hyaluronic acid to create bubbles that are less likely to break. They could also be made to bounce using woolen gloves or work gloves.

Microneedle technology can be used to increase skin permeability. It is also possible to administer hyaluronic acid to the skin through painful injections, and it is thought that processing hyaluronic acid into the shape of fine needles would allow it to be absorbed through the skin without pain. It could also be used in medical patch-type vaccines to allow the absorption of medicinal ingredients.

Polyquaternium (polyquaternium-51) has the structure shown in Chemical formula 15, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

There are many types of polyquaternium, including polyquaternium-n (n = 1 to 112), each of which has a different raw material composition, with a representative polyquaternium-51 being the above-mentioned "Chemical formula 15." It is produced by polymerizing 2-methacryloyloxyethyl phosphorylcholine, which has a polar group of phosphatidylcholine, a type of phospholipid that constitutes cell membranes, with butyl methacrylate in an 8:2 ratio. It is also available commercially.

Polyquaternium-51 is a cationic surfactant and one of the lipidures. It is a water-soluble polymer that is similar to the components of human cell membranes, and has twice the moisturizing power and moisturizing effect of hyaluronic acid. It is more functional than hyaluronic acid in that its moisturizing properties do not decrease even when it gets wet with sweat or water. It also supports the skin's barrier function, prevents rough skin, and keeps the skin in beautiful condition.

Lipidure (registered trademark) has the structure shown in Chemical Formula 16, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

The above-mentioned Lipidure is a water-soluble polymer, and refers to a homopolymer of 2-methacryloyloxyethyl phosphorylcholine, which has a structure similar to that of phospholipids, or a copolymer containing 2-methacryloyloxyethyl phosphorylcholine. Lipidure is commercially available. A representative Lipidure is shown above as "Chemical formula 16."

The generic name of the homopolymer (Lipidure HM) is poly(2-methacryloyloxyethylphosphorylcholine), and its CAS registration number is [67881-99-6]. The CAS registration number of the copolymer with n-butyl methacrylate (Lipidure PMB) is [125275-25-4]. In the ingredient label, it is listed as "MPC" or "Lipidure".

This Lipidure has moisturizing properties and a moisturizing effect, and even when dry one hour after rinsing with water, it maintains its high moisturizing power and effect, and its moisturizing power is about twice that of hyaluronic acid. Because it maintains its high moisturizing power even after rinsing with water after application, this Lipidure is suitable for hand cream, contact lens storage solution, shampoo, conditioner, etc.

Sodium dilauroyl glutamate lysine (Pellicer) has the structure shown in Chemical Formula 17, and this sodium dilauroyl glutamate lysine (Pellicer) has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

In Chemical formula 17, Ra represents a hydrocarbon group having 1 to 23 carbon atoms, Rb represents hydrogen or a hydrocarbon group having 1 to 3 carbon atoms, Y represents a carboxyl group, a sulfonic acid group, a sulfate ester group, a phosphate ester group, or a salt thereof, Z represents -NRb- (Rb is hydrogen or a hydrocarbon group having 1 to 10 carbon atoms), -O-, or -S-, w and m are each 0, 1, or 2, and w and m are not 0 at the same time, and n represents an integer from 2 to 20. X represents a hydrocarbon chain having a molecular weight of 1,000,000 or less. Sodium dilauroyl glutamate lysine (Pellicer) is also commercially available.

Sodium dilauroyl glutamate lysine (Pellicer) can be obtained by reacting an N-acyl acidic amino acid anhydride with a compound having a molecular weight of 1,000,000 or less and containing g (g is n or more) functional groups selected from hydroxyl groups, amino groups, and thiol groups (hereafter referred to as a g-valent compound).

The above-mentioned sodium dilauroyl glutamate lysine (Pellisea) is also a moisturizing and humectant made from vegetable fatty acids and amino acids (glutamic acid, lysine). It has excellent moisturizing and humectant properties, penetrates the stratum corneum, and works to straighten out disordered structures, supporting the barrier function and increasing water retention. It is also a condensation product in which two sodium lauroyl glutamate units, which are anionic surfactants, are linked with lysine, a type of basic amino acid, and is also an anionic gemini surfactant with two chains and three hydrophilic groups.

The above-mentioned sodium dilauroyl glutamate lysine (Pellicer) is a highly biodegradable, highly functional cosmetic ingredient made from natural fatty acids and the amino acids glutamic acid and lysine. It is a cosmetic ingredient developed by Asahi Kasei Chemicals Corporation (cosmetic label name: sodium dilauroyl glutamate lysine), and is thought to have quicker penetration and longer lasting effects than conventional PPT and the like. It also has an improving effect on hair.

This sodium dilauroyl glutamate lysine (Pericea) is a highly biodegradable, highly functional cosmetic ingredient made from natural fatty acids and the amino acids glutamic acid and lysine. It penetrates into the stratum corneum of the human body and works in the same way as ceramide, improving the skin's barrier function and promoting the recovery of skin elasticity and texture. It provides an excellent feeling of use with excellent moisturizing and penetrating effects.

(7) Chelating component In a sanitizing composition containing 0.001% to 50% by weight of the above-mentioned methyl coumarate ester, or in some cases a mixture of this methyl coumarate and coumarin, excluding water, a bactericidal component is mixed almost uniformly at 0.001% to 75% by weight, not exceeding a total of 100% by weight, or not mixed therein, a moisturizing component is mixed almost uniformly at 0.001% to 50% by weight, not exceeding a total of 100% by weight, or not mixed therein, and a chelating component is mixed almost uniformly at 0.001% to 40% by weight, not exceeding a total of 100% by weight, or not mixed therein.

Chelating components are molecules or ions with two or more coordinating atoms that form a ring structure containing the metal when coordinated to a metal. Such compounds are called chelates or chelating compounds. Chelate compounds (chelates) are compounds that combine with metals to form chelate rings, and are also called chelating agents, and are used to remove harmful heavy metals from the body.

An example of this chelating component is disodium edetate. Disodium edetate has the structure shown in Chemical formula 18, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

If a cleansing composition contains metal ions, they can promote oxidation, causing odor changes in oils and fats, discoloration, inhibition of functional ingredients, cloudiness, precipitation, poor foaming, and the production of metal soaps that can make hair squeaky and rough skin. These problems can be prevented by using the above-mentioned chelating ingredients, such as disodium edetate. Disodium edetate is commercially available.

The chelating component may be ethylenediaminetetraacetic acid. Ethylenediaminetetraacetic acid has the structure shown in Chemical Formula 19, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

If a cleansing composition contains metal ions, they can promote oxidation, causing odor and discoloration of oils and fats, inhibition of functional ingredients, cloudiness, precipitation, and poor foaming, as well as the production of metal soaps that can make hair squeaky and rough skin. These problems can be prevented by using the above-mentioned chelating ingredients, such as disodium edetate. Ethylenediaminetetraacetic acid is commercially available.

Citric acid may also be used as the chelating component. Citric acid has the structure shown in Chemical Formula 20, and has the following chemical properties:

なお、上記及び下記の化学式中の数字は、本来は各化学記号の右下に小さく表示するが、本願では見やすくするため便宜上半角の通常の大きさで大きく表記する。

In addition, the numbers in the above and following chemical formulas are normally displayed in small letters to the lower right of each chemical symbol, but in this application they are displayed in normal large half-width size for ease of viewing.

If the cleaning composition contains metal ions, they can promote oxidation, resulting in a loss of flavor, but this can be prevented by the chelating ingredients mentioned above, such as citric acid. Citric acid is commercially available.

Other chelating ingredients such as gluconic acid and phytic acid may be used. Gluconic acid and phytic acid are known and commercially available. The chelating ingredient may be one or more of disodium edetate, ethylenediaminetetraacetic acid, citric acid, gluconic acid, and phytic acid.

(8) Effects of the Cleansing Composition The use of coumaric acid methyl ester alone exerts a synergistic anti-inflammatory effect. Figure 1 shows that as the amount of coumaric acid methyl ester added is gradually increased, the amount of nitric oxide (NO) produced in mouse monocytic leukemia RAW264.7 cells decreases. Nitric oxide (NO) is a substance that induces inflammation.

Figure 2 shows that as the amount of coumaric acid methyl ester added is gradually increased, the expression of IL-6 mRNA (messenger RNA) is gradually suppressed in mouse monocytic leukemia RAW264.7 cells.

Figure 3 shows that as the amount of coumaric acid methyl ester added is gradually increased, the expression of iNOS mRNA is gradually suppressed in mouse monocytic leukemia RAW264.7 cells.

Figure 4 shows that as the amount of coumaric acid methyl ester added is gradually increased, IL-1β mRNA expression is gradually suppressed in mouse monocytic leukemia RAW264.7 cells.

Figure 5 shows that the elimination rate of DPPH gradually improves as the amount of coumaric acid methyl ester added is gradually increased.

The above properties were almost the same for p-coumaric acid methyl ester, o-coumaric acid methyl ester, m-coumaric acid methyl ester, and coumarin. These also inhibit the production of NO (nitric oxide) by LPS (an inflammation-inducing substance), and inhibit the expression of mRNA for inflammation-inducing genes iNOS (inducible nitric oxide synthase), IL-6 (interleukin-6), and IL-1β (interleukin-1β), and have anti-inflammatory activity at the cellular level. They also have antioxidant effects. They also improve the elimination rate of DPPH.

The above-mentioned iNOS is an enzyme that synthesizes nitric oxide from L-arginine. The above-mentioned IL: interleukin is a general term for peptides and proteins secreted by lymphocytes and macrophages primarily to regulate immune responses, and the above-mentioned "-6" and "-1β" are symbols that distinguish each peptide and protein. The above-mentioned DPPH (diphenyl-1-picrylhydrazyl) is a radical.

It can also sterilize or remove various bacteria such as Staphylococcus aureus, Bacillus subtilis, Clostridium perfringens, and Escherichia coli, as well as various viruses such as coronavirus, influenza virus, norovirus, and new coronavirus, and other bacteria. However, it does not remove the amino acids, oils, and moisture necessary for the skin, and is excellent for moisturizing, water retention, oil retention, and oil retention.

(9) Other embodiments and examples The present invention is not limited to the above-mentioned examples, and some steps can be omitted without departing from the spirit of the present invention. For example, the alcohol may be a monohydric alcohol, a dihydric alcohol, a trihydric alcohol, a tetrahydric alcohol, a pentahydric alcohol, a hexahydric alcohol, ..., or a primary alcohol, a secondary alcohol, a tertiary alcohol, a quaternary alcohol, ..., or any hydroxy compound in which the hydrogen atom of a chain or ring-shaped hydrocarbon is replaced with a hydroxyl group OH, such as other glycols, other glycerins, ethyl alcohol, methyl alcohol, butanediol, propanediol, butyl alcohol, propanol, t-butanol, hexane, lower alcohols, and higher alcohols. The alcohol is preferably one that has moisturizing properties, but may not have moisturizing properties in some cases. The amount of alcohol is the same as or less than the amount of water, but may be more than the amount of water.

The water may be replaced in whole or in part by the above alcohols or oils (olive oil, jojoba oil, coconut oil, palm oil, castor oil, peppermint oil, almond oil, soybean oil, camellia oil, sesame oil, safflower oil, coconut oil, sunflower oil, corn oil, rapeseed oil, rice oil, peanut oil, cottonseed oil), or the water may be mixed with the above alcohol or oil, or the water may be omitted. The oils may be of vegetable origin as mentioned above, but may also include those of animal origin.

Oshimazakura, Yamazakura, Somei-Yoshino, Satozakura or Higanzakura cherry trees from which coumaric acid methyl ester or coumarin has been extracted may be filtered from the water and discarded, or left in the water or alcohol. The oil may be a liquid or solid oil such as olive oil, jojoba oil, coconut oil, palm oil, castor oil, peppermint oil, almond oil, soybean oil, camellia oil, sesame oil, safflower oil, coconut oil, sunflower oil, corn oil, rapeseed oil, rice oil, peanut oil, cottonseed oil, or a compound or composition derived from these oils, or may be alcohol, water, carbon tetrachloride, ether or carbon tetrachloride.

In this case, a surfactant may be mixed in an amount of 0.001% to 30% by weight, preferably 0.1% to 10% by weight. This causes the topical agent composition or the aqueous solution to be in an emulsion or microemulsion state.

The above bactericidal components may be other than sodium benzoate, benzalkonium chloride, iodopropynyl butylcarbamate, cymene-5-ol, and phenoxyethanol. The above moisturizing components may be other than sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, and sodium dilauroyl glutamate lysine (pelicea).

The chelating ingredient may be one other than disodium edetate, ethylenediaminetetraacetic acid, citric acid, gluconic acid, and phytic acid. The alcohol may be one other than butylene glycol (1,3-butylene glycol), dipropylene glycol, glycerin, ethyl alcohol, and methyl alcohol.

The above-mentioned cleansing composition contains the above-mentioned water, methyl ester of coumaric acid, methyl ester of p-coumaric acid, methyl ester of o-coumaric acid, methyl ester of m-coumaric acid, coumarin, antiseptic ingredient, moisturizing ingredient, ingredient with chelating action, ingredient extracted from Oshima cherry, Yamazakura, Somei-Yoshino, Satozakura or Higanzakura, sodium benzoate, benzalkonium chloride, iodopropynyl butylcarbamate, cymen-5-ol, phenoxyethanol, sodium hyaluronate, sodium lactate. thorium, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, sodium dilauroyl glutamate lysine, disodium edetate, ethylenediaminetetraacetic acid, citric acid, gluconic acid, phytic acid, butylene glycol (1,3-butylene glycol), dipropylene glycol, glycerin, ethyl alcohol, methyl alcohol, some or all of the cleansing composition may be omitted, and each may be in liquid, solid, gas, sol, or gel form.

(10) Effects of Other Inventions [1] A cleansing composition comprising 0.001% to 50% by weight of methyl coumarate, 0.001% to 75% by weight of a bactericidal component, and 0.001% to 50% by weight of a moisturizing component, the total amount of which, excluding water, is mixed almost uniformly within a range not exceeding 100% by weight, thereby providing cleansing, disinfection, moisturizing, and a pleasant fragrance.

[2] The cleaning composition according to claim 1, further comprising coumarin mixed in the cleaning composition in an almost uniform amount of 0.001% to 50% by weight, not exceeding 100% by weight in total. This provides cleaning, disinfection, moisturization, and a pleasant fragrance.

[3] The cleansing composition according to claim 2, characterized in that the coumaric acid methyl ester and/or coumarin are extracted from Oshimazakura, Yamazakura, Somei-Yoshino, Satozakura or Higanzakura. This provides cleansing, disinfection, moisturizing and a pleasant fragrance.

[4] The cleansing composition according to claim 3, characterized in that the coumaric acid methyl ester and/or coumarin are extracted from the leaves, flowers, stems, fruits, bark or trunks of Oshimazakura, Yamazakura, Somei-Yoshino, Satozakura or Higanzakura with alcohol, water, oil, ether or carbon tetrachloride. This provides cleansing, disinfection, moisturizing and a pleasant fragrance.

[5] The cleaning composition according to claim 1, characterized in that the bactericidal component is one or more of sodium benzoate, benzalkonium chloride, iodopropynyl butylcarbamate, cymene-5-ol, and phenoxyethanol. This provides cleaning, disinfection, moisturization, and a pleasant fragrance. In addition, the bactericidal action of these bactericidal components prevents the proliferation of microorganisms that emit odors, smells, and fragrances other than the fragrance of coumaric acid methyl ester and/or coumarin, so the fragrance is not altered.

[6] The cleansing composition according to claim 1, characterized in that the moisturizing component is one or more of sodium hyaluronate, butylene glycol (1,3-butylene glycol), sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, and sodium dilauroyl glutamate lysine. This provides cleansing, disinfection, moisturization, and a pleasant fragrance.

[7] The cleaning composition according to claim 1, further comprising a substantially uniform mixture of 0.001% to 40% by weight of a component with a chelating effect, the total amount of which does not exceed 100% by weight. This prevents odors, discoloration, inhibition of functional components, turbidity, precipitation, and poor foaming caused by metal ions, as well as hair squeaking and rough skin caused by the generation of metal soap.

[8] The cleansing composition according to claim 7, characterized in that the chelating component is one or more of disodium edetate, ethylenediaminetetraacetic acid, citric acid, gluconic acid, and phytic acid. This prevents odor, discoloration, inhibition of functional components, turbidity, precipitation, and poor foaming caused by metal ions, as well as hair squeaking and rough skin caused by the generation of metal soaps.

[9] The cleansing composition according to claim 3, characterized in that the alcohol is one or more of butylene glycol (1,3-butylene glycol), dipropylene glycol, glycerin, ethyl alcohol, and methyl alcohol.

This allows ingredients that are poorly soluble in water or difficult to extract with water to be dissolved in alcohol or extracted with alcohol, ultimately forming an aqueous solution, allowing the efficacy of the ingredients that are poorly soluble in water or difficult to extract with water to be exerted even in the aqueous solution, allowing the cleansing ability of the cleansing composition to be fully exerted, while also maintaining moisturizing properties, so that moisturizing and skin protection can be achieved even after dirt removal, washing, cleaning, or sterilization.

[10] The cleaning composition according to claim 1, characterized in that the cleaning composition is mixed with 10% to 500% by weight of water for every 1% by weight of the cleaning composition.

This allows ingredients that are poorly soluble in water or difficult to extract with water to be dissolved in alcohol or extracted with alcohol, ultimately forming an aqueous solution, allowing the efficacy of the ingredients that are poorly soluble in water or difficult to extract with water to be exerted even in the aqueous solution, allowing the cleansing ability of the cleansing composition to be fully exerted, while also maintaining moisturizing properties, so that moisturizing and skin protection can be achieved even after dirt removal, washing, cleaning, or sterilization.

[11] The cleansing composition according to claim 1, characterized in that the cleansing composition is impregnated into paper, cloth or resin and applied to the body. This allows dirt to be easily wiped away, cleans the body, prevents the growth of bacteria, makes the skin smooth, and gives off a pleasant fragrance. Therefore, the body can be kept clean even when bathing is not possible, such as during a disaster.

[12] A method for producing coumaric acid methyl ester or coumarin, comprising the steps of: mixing the leaves, flowers, stems, fruits, bark or trunks of Oshimazakura, Yamazakura, Somei-Yoshino, Satozakura or Higanzakura, either as is, finely cut or powdered, with alcohol, water or oil, and extracting coumaric acid methyl ester or coumarin by evaporating the alcohol or as is. This provides cleaning, disinfection, moisturizing and a pleasant fragrance.

It cleans, disinfects, moisturizes, and has a pleasant fragrance. The cleansing composition is a mixture of 0.001% to 50% by weight of methyl coumarate, 0.001% to 75% by weight of a bactericidal component, and 0.001% to 50% by weight of a moisturizing component, excluding water.

In addition, coumarin is mixed in an amount of 0.001% to 50% by weight. The above coumaric acid methyl ester and/or coumarin are extracted by finely cutting or powdering Oshima cherry, Yamazakura, Somei-Yoshino cherry, Satozakura or Higanzakura cherry trees and mixing them with alcohol, water, oil, ether or carbon tetrachloride.

Claims (12)

A cleansing composition characterized by being substantially uniformly mixed with 0.001% to 50% by weight of methyl coumarate, 0.001% to 75% by weight of a bactericidal component, and 0.001% to 50% by weight of a moisturizing component, the total amount of which does not exceed 100% by weight, excluding water. The cleaning composition according to claim 1, further comprising coumarin mixed in the cleaning composition in an almost uniform amount of 0.001% to 50% by weight, not exceeding 100% by weight in total. The cleansing composition according to claim 2, characterized in that the coumaric acid methyl ester and/or coumarin are extracted from Oshimazakura, Yamazakura, Somei-Yoshino, Satozakura or Higanzakura. The cleansing composition according to claim 3, characterized in that the coumaric acid methyl ester and/or coumarin are extracted from the leaves, flowers, stems, fruits, bark or trunks of Oshimazakura, Yamazakura, Somei-Yoshino, Satozakura or Higanzakura with alcohol, water, oil, ether or carbon tetrachloride. The cleaning composition according to claim 1, characterized in that the bactericidal component is one or more of sodium benzoate, benzalkonium chloride, iodopropynyl butylcarbamate, cymen-5-ol, and phenoxyethanol. The cleansing composition according to claim 1, characterized in that the moisturizing ingredient is one or more of sodium hyaluronate, butylene glycol, sodium lactate, potassium lactate, lactic acid, hyaluronic acid, polyquaternium, lipidure, and sodium dilauroyl glutamate lysine. The cleansing composition according to claim 1, further comprising a substantially uniform mixture of 0.001% to 40% by weight of a component having a chelating effect, the total amount of which does not exceed 100% by weight. The cleansing composition according to claim 7, characterized in that the chelating ingredient is one or more of disodium edetate, ethylenediaminetetraacetic acid, citric acid, gluconic acid, and phytic acid. The cleaning composition according to claim 3, characterized in that the alcohol is one or more of butylene glycol, dipropylene glycol, glycerin, ethyl alcohol, and methyl alcohol. The cleaning composition according to claim 1, characterized in that the cleaning composition is mixed with 10% to 500% by weight of water for every 1% by weight of the cleaning composition. The cleansing composition according to claim 1, characterized in that the cleansing composition is impregnated into paper, cloth or resin and applied to the body. A method for producing coumaric acid methyl ester or coumarin, comprising mixing the leaves, flowers, stems, fruits, bark or trunks of Oshima cherry, Yamazakura cherry, Somei-Yoshino cherry, Satozakura cherry or Higanzakura cherry, either as is, finely cut or powdered, with alcohol, water, oil, ether or carbon tetrachloride, and extracting coumaric acid methyl ester or coumarin by evaporating the alcohol, water, oil, ether or carbon tetrachloride, or by using the leaves as is.

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