KR102236391B1 - Personal cleansing composition comprising Magnolia officinalis extract - Google Patents

Abstract

The present invention relates to a composition for cleansing the human body comprising a husk extract, more specifically, a human body comprising a husk extract, a fatty acid, and a fragrance having a ClogP (octanol-water partition coefficient) value of 3 or more. It relates to a cleaning composition. The composition for cleaning the human body of the present invention is excellent in inhibiting and removing body odor-causing microorganisms, has excellent antibacterial activity against acne bacteria, is effective in treating acne, and has excellent reverberation properties. In addition, since the composition for cleaning the human body of the present invention is made of natural ingredients and is safe for the human body, it can be used for maintaining and improving skin health regardless of age.

Description

Personal cleansing composition comprising Magnolia officinalis extract

The present invention relates to a composition for cleaning the human body comprising a Hubak extract, and more particularly, to a composition for cleaning the human body having excellent antibacterial effect against major microorganisms causing acne and excellent reverberation by including the Hubak extract.

Among skin diseases, the onset and exacerbation of body odor and acne, which are of interest in the present invention, are closely related to microorganisms, especially bacteria. First, body odor is generated by microorganisms, etc., decomposing ecrine sweat, apocrine sweat, sebum, or contaminants secreted from the human body. The first secreted ecrine sweat or apocrine sweat is odorless, but the action of various microorganisms residing in the epidermis, hair, and pores of the skin, especially those related to body odor, causes unpleasant body odors, such as odor, foot odor, and odor.

Skin, to the number of flora present, typical to the Staphylococcus aureus is Staphylococcus (Staphylococcus), Streptococcus micro Rhodococcus (Micrococcus), Corynebacterium (Corynebacterium), P ET Los Forum (Pityrosporum), or E. coli (E .coli ), and in particular, Corynebacterium is known to be found in many people with strong odor due to an unpleasant odor that irritates the nose. Next, acne is a chronic inflammatory disease of the furry sebaceous glands that occurs mainly on the face, chest, and neck of young men and women such as puberty, and it is known as comedones, papules, pustules, cysts, or nodules. It forms, and in severe cases, is a lesion that can leave a scar.

Although the mechanism of occurrence of acne is not yet clearly identified, there are generally four factors: 1) proliferation of acne bacteria, 2) increase in sebum secretion, 3) abnormally increased hair follicle wall hyperkeratosis, and 4) other inflammatory factors. It can be summarized as, and acne treatment methods are also based on the principle of eliminating these causes.

There is a change in the fat content of the sebum of acne patients, and the content of linoleic acid and cholesterol in acyl ceramide decreases, and the content of squalene and fatty acids increases. This change in fat composition causes an imbalance between cholesterol in the hair follicle and cholesterol sulfate, and thus, the binding between keratinocytes in the hair follicle is enhanced, resulting in follicular retention hyperkeratosis. As a result, the sebum stagnated in the hair follicle blocks the hair follicle and blocks air circulation, so that the inside of the hair follicle becomes an environment in which Propionibacterium acnes, an anaerobic bacterium residing in the hair follicle, can grow well. These acne bacteria secrete lipolytic enzymes and chemotactic factors to make fatty acids, causing white blood cells to gather around the hair follicles, and they stimulate and destroy the walls of the hair follicles, causing an inflammatory reaction as the hair follicle contents flow into the dermis.

There are many known antibacterial substances that inhibit such body odor and the reproduction of acne bacteria, such as triclosan, triclocarban, benzalkonium chloride, benzethonium chloride, chlorhexidine hydrochloride, and glue. Chlorhexidine gluconate, fanesol, copper gluconate, or zinc gluconate; Plant oils or plant extracts such as tea tree oil, cloves, fennel, mint, or sophora; Or chitin or a derivative thereof.

However, these substances may not exhibit sufficient antibacterial effect against acne bacteria with only a small amount, and there is a risk of side effects such as skin redness or dry skin when applied in excessive amounts, and popular antibacterial substances such as triclosan and triclocarban are used for a long period of time. It increases the resistance to pathogens in the skin, and the possibility of disturbance of endocrine hormones and carcinogenicity has been reported, and it is difficult to exert sufficient antibacterial effect due to lack of skin adsorption for cleaning products.

Therefore, the problem to be solved by the present invention is a composition for human body cleaning that exhibits a strong antibacterial effect on body odors including skin flora and acne bacteria, and has excellent skin adsorption even after washing, so that it can be used in small amounts and has less side effects on the skin. Is to provide.

In order to solve the above problems, the present invention provides a composition for human body cleaning comprising a flavoring having a ClogP (octanol-water partition coefficient) value of 3 or more according to the following equation: do.

[Equation 1]

The inventors of the present invention were researching to develop a composition for cleaning the human body with excellent skin hygiene enhancement, unpleasant body odor removal, and acne improvement effects, and found that the extract has a strong antibacterial effect against microorganisms that cause body odor and acne. I did. In addition, when the composition for cleaning the human body contains a fatty acid and a perfume having a ClogP value of 3 or more together with the extract of Hubak extract, it was found that the skin adsorption of the Hubak extract was increased and the reverberation property was excellent even after washing, thereby completing the present invention.

In the present invention, the Hubak extract may be obtained by extracting from various organs or parts of the Hubak tree, that is, leaves, flowers, fruits, stems, roots, branches, or bark. The extract may be obtained by a solvent extraction method using water or an organic solvent, a supercritical extraction method, a steam distillation method, or an ultrasonic extraction method as an extraction method commonly used in the technical field to which the present invention belongs. Preferably, the extract may be extracted using a supercritical extraction method using carbon dioxide.

As the organic solvent that can be used in the solvent extraction method, an organic solvent commonly used in the technical field may be used, and lower alcohols such as methanol, ethanol, isopropyl alcohol, and butanol; Polyhydric alcohols such as glyceron, ethylene glycol, propylene glycol, and 1,3-butylene glycol; And hydrocarbon-based solvents such as petroleum ether, methyl acetate, ethyl acetate, benzene, hexane, methylene chloride, diethyl ether, dichloromethane, and chloroform.

The extract may be a liquid extract obtained by a solvent extraction method, or a solution obtained by diluting it in a solvent, a supercritical extract using carbon dioxide, or a powdered extract thereof. The powdering may be performed by a conventional method known in the art such as vacuum drying, freeze drying, or spray drying. Preferably, the thick bark extract may be a supercritical extract using carbon dioxide.

The extract of the present invention includes not only the extraction solvent described above, but also an extract that has undergone a conventional purification process. Specifically, the extract of the present invention is a purification process after extraction with an extraction solvent, for example, membrane separation using a filtration membrane having a cut-off value with a certain molecular weight, various for separation according to size, charge, hydrophobicity, or affinity, etc. It may be used by additionally performing a purification process such as separation by chromatography.

In the present invention, the fugitive extract may be included in an amount of 0.01 to 2% by weight, preferably 0.02 to 1.5% by weight, and more preferably 0.03 to 0.8% by weight, based on the total weight of the composition. If the content of the extract is less than 0.01% by weight, antibacterial activity does not appear, and if it exceeds 2% by weight, economy and formulation stability are poor, which is not preferable.

In the composition of the present invention, the fatty acid may include C8-20 carboxylic acids including lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, and linoleic acid derived from animal fat or vegetable fats and oils; Fatty acids derived from vegetable oils, including palm oil, palm kernel oil, soybean oil, rapeseed oil, corn oil, rapeseed oil, sunflower oil, safflower oil, cottonseed oil, sesame oil, rice bran oil, camellia oil, castor oil, olive oil, and palm oil; Fatty acids derived from animal fats and oils (eg, tallow acid), including tallow, pork fat, sunny fat, fish oil, whale oil, and tuna oil; At least one selected from the group consisting of fatty alcohol, mineral oil, and paraffin may be used, but is not limited thereto. Preferably, as the fatty acid, palm oil fatty acid derived from palm oil or palm kernel oil, palm kernel oil fatty acid, or tallow acid derived from tallow, etc. may be used.

In the present invention, the fatty acid is bound to the extract having antimicrobial activity in the composition to increase adsorption to the skin and impart an excellent emollient effect, in order to provide an excellent emollient effect, 1 to 30% by weight, preferably 2 to 15% by weight, more Preferably it may be included in 3 to 7% by weight. If the fatty acid content is less than 1% by weight, the skin adsorption effect is remarkably deteriorated, and if it exceeds 30% by weight, the feeling and stability are not good, which is not preferable.

In the composition of the present invention, fragrances having a ClogP value of 3 or more have high skin retention even after washing and have excellent reverberation properties. In the composition of the present invention, the fragrance having a ClogP value of 3 or more may be included in an amount of 0.1 to 5% by weight, preferably 0.5 to 3% by weight, based on the total weight of the composition. If the content of the fragrance is less than 0.1% by weight, the reverberation effect is remarkably deteriorated, and if it exceeds 5% by weight, the formulation stability is deteriorated.

In addition, the present invention provides a composition for cleansing a human body comprising 0.01 to 2% by weight of a fume extract and 1 to 30% by weight of a fatty acid, and a ClogP value of 3 or more based on the total weight of the composition. For the purposes of the present invention, in the case of a composition comprising a combination of components of the specific weight ratio, the antimicrobial activity and reverberation against a body odor-causing microorganism or acne bacteria are the most excellent.

In addition, the composition for cleaning the human body of the present invention is a group consisting of an alkali salt of a higher fatty acid, a surfactant, a wetting agent, a sequestering agent, and purified water, etc. It may further include one or more additives selected from.

The alkali salt of the higher fatty acid may serve to provide an excellent cleaning effect, and as such higher fatty acid, one or more selected from the group consisting of lauric acid, myristic acid, palmitic acid, stearic acid, and oleic acid may be used. However, it is not limited thereto. The higher fatty acid alkali salt may be included in an amount of 5 to 80% by weight based on the total weight of the composition.

The surfactant may be used as a bubble enhancer, and at least one selected from the group consisting of anionic surfactants, nonionic surfactants, and amphoteric surfactants may be used.

The anionic surfactant is not particularly limited as long as it can be used in a conventional cosmetic composition, and fatty acid soap (sodium laurate, sodium palmitate, etc.); Higher alkyl sulfate ester salts (sodium lauryl sulfate, potassium lauryl sulfate, etc.); Alkyl ether sulfate ester salts (POE-lauryl sulfate triethanolamine, POE-lauryl sodium sulfate, etc.); N-acyl sarcosine acid (lauroyl sarcosine sodium, etc.); Higher fatty acid amide sulfonates (N-myristoyl-N-methyltaurine sodium, palm oil fatty acid methyltauride sodium, laurylmethyltauride sodium, etc.); Phosphoric acid ester salts (POE-oleyl ether phosphate sodium, POE-stearyl ether phosphate, etc.); Sulfosuccinate (sodium di-2-ethylhexyl sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, sodium lauroyl polypropylene glycol sulfosuccinate, etc.); Alkylbenzenesulfonates (sodium linear decylbenzenesulfonic acid, triethanolamine linear decylbenzenesulfonic acid, linear decylbenzenesulfonic acid, etc.); Higher fatty acid ester sulfate ester salts (hardened palm oil fatty acid glycerin sodium sulfate, etc.); N-acyl glutamate (N-lauroyl glutamate monosodium, N-stearoyl glutamate disodium, N-myristoyl-L-glutamic acid monosodium, etc.); Sulfated oil (lot oil, etc.); POE-alkylethercarboxylic acid; POE-alkyl allyl ether carboxylic acid salt; α-olefin sulfonate; Higher fatty acid ester sulfonates; Secondary alcohol sulfate ester salt; Higher fatty acid alkylolamide sulfate ester salts; Sodium lauroyl monoethanolamide succinate; N-palmitoylaspartic acid ditriethanolamine; And one or more selected from the group consisting of sodium caseinate and the like may be used, but is not limited thereto.

As the nonionic surfactant, a lipophilic nonionic surfactant or a hydrophilic nonionic surfactant may be used, and it is not particularly limited as long as it can be used in a conventional cosmetic composition. As the lipophilic nonionic surfactant, sorbitan fatty acid Esters (sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2 -Ethylhexyl diglycerol sorbitan, tetra-2-ethylhexyl diglycerol sorbitan, etc.); Glycerin polyglycerol fatty acids (mono cottonseed oil fatty acid glycerin, monoerucic acid glycerin, sesquioleic acid glycerin, monostearic acid glycerin, α,α'-oleic acid pyroglutamic acid glycerin, monostearic acid glycerin malic acid, etc.); Propylene glycol fatty acid esters (propylene glycol monostearate, etc.); Hydrogenated castor oil derivatives; Examples of the hydrophilic nonionic surfactants such as glycerin alkyl ethers include POE-sorbitan fatty acid esters (POE-sorbitan monooleate, POE-sorbitan monostearate, POE-sorbitan tetraoleate, etc.); POE-sorbit fatty acid esters (POE-sorbit monolaurate, POE-sorbit monooleate, POE-sorbitpentaoleate, POE-sorbit monostearate, etc.); POE-glycerin fatty acid esters (POE-glycerin monostearate, POE-glycerin monoisostearate, POE-glycerin triisostearate, etc.); POE-fatty acid esters (POE distearate, POE-monodioleate, ethylene glycol distearate, etc.); POE-alkyl ethers (POE-lauryl ether, POE-oleyl ether, POE-stearyl ether, POE-behenyl ether, POE-2-octyldodecyl ether, POE-cholestanol ether, etc.); Pluronic type (Pluronic, etc.); POE·POP-alkyl ethers (POE·POP-cetyl ether, POE·POP-2-decyltetradecyl ether, POE·POP-monobutyl ether, POE·POP-hydrogenated lanolin, POE·POP-glycerin ether, etc.); Tetra POE·tetra POP-ethylenediamine condensation products (Tetronic, etc.); POE-castor oil hydrogenated castor oil derivatives (POE-castor oil, POE-cured castor oil, POE-cured castor oil monoisostearate, POE-cured castor oil triisostearate, POE-cured castor oil monopyroglutamic acid monoiso Stearic acid diester, POE-cured castor oil maleic acid, etc.); POE beeswax lanolin derivatives (POE-sorbit beeswax, etc.); Alkanolamides (palm oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, etc.); POE-propylene glycol fatty acid ester; POE-alkylamine; POE-fatty acid amide; Sucrose fatty acid ester; Alkylethoxydimethylamine oxide; And trioleyl phosphoric acid, and the like, and one or more selected from the group consisting of them may be used, but the present invention is not limited thereto.

In addition, the present invention may contain amphoteric surfactants to aid in cleaning power and maintain rich foam. Amphoteric surfactants are not particularly limited as long as they can be used in conventional cosmetic compositions, and imidazoline amphoteric surfactants (2-undecyl-N,N,N-(hydroxyethylcarboxymethyl)-2-imide Dazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.); And betaine surfactants (2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylamino acetic acid betaine, alkyl betaine, amide betaine, sulfo betaine, etc.), etc. At least one selected from the group consisting of may be used, but is not limited thereto.

In the present invention, the surfactant may be included in an amount of 0.1 to 30% by weight based on the total weight of the composition.

The humectant may be used to impart a moisturizing effect to the skin after washing, and any one or more selected from the group consisting of concentrated glycerin, glycerin, sorbitol aqueous solution, amorphous sorbitol aqueous solution, polyethylene glycol, and propylene glycol may be used. . In the present invention, the humectant may be used in an amount of 0.1 to 20% by weight based on the total weight of the composition.

In the composition of the present invention, the sequestering agent for metal ions is a material that suppresses dispersal of the composition by chelating metal ions to prevent oxidation of fatty acids, and phosphoric acid-based compounds and EDTA may be used. More specifically, the sequestering agent is sodium phosphate, monosodium phosphate, disodium phosphate, trisodium phosphate, tetrasodium etidronate. , Sodium tripholyphosphate, Sodium hexametaphosphate, Tetrasodium pyrophosphate, Sodium acid pyrophosphate, Disodium EDTA, and Tetrasodium EDTA. One or more selected from the group consisting of Tetrasodium EDTA may be used, etc. In the present invention, the metal ion sequestering agent may be used in an amount of 0.01 to 0.5% by weight based on the total weight of the composition.

In the composition for cleansing the human body according to the present invention, the Hubak extract acting as an active ingredient may include Magnolol and Honokiol as main components in a weight ratio of about 1:1. The magnolol and honokiol may be included in an amount of 90% by weight or more, based on the total weight of the extract of Hubak extract.

The composition for cleansing the human body according to the present invention may include a mixture of 1:10 to 50 fatty acids and 1:10 to 50 (thick extract: fatty acid), and a fragrance having a ClogP value of 3 or more. Preferably, the weight ratio may be mixed in a ratio of 1:20 to 40 (thick extract: fatty acid). When the weight ratio of fatty acids is less than the 1:10 (thick peel extract: fatty acid) weight ratio of the mixture, it is difficult to expect an increase in the antibacterial effect because the skin residual concentration of the thick peel extract is low. In addition, when the weight ratio of fatty acids is exceeded based on the weight ratio of 1:50 (thick leaf extract: fatty acid) of the mixture, the fatty acid is easily deodorized, bubbles are reduced, and the odor is strong, making it difficult to use. In addition, the composition for cleaning the human body according to the present invention may include a mixture in which the extract, fatty acids, and flavors having a ClogP value of 3 or more are mixed in a weight ratio of 1:10:5 to 1:50:25. The composition comprising the mixture is remarkably excellent not only in antibacterial activity against harmful bacteria, but also in reverberation properties for the purposes of the present invention.

In addition, the mixture may be included in 1 to 35% by weight, preferably 3 to 25% by weight, based on the total weight of the composition. If the mixture is less than 1% by weight, the antibacterial effect is insignificant and the desired effect cannot be expected. If it is more than 35% by weight, it may cause skin irritation such as itchiness, and manufacturing is not easy.

The composition for cleaning the human body according to the present invention has excellent antibacterial effect against bacteria that cause odor and acne bacteria. More specifically, the composition has excellent proliferation inhibition and removal effects for Corynebacterium xerosis , which is the cause of odor, and Propionibacterium acnes, which is acne bacteria, so that body odor removal and acne treatment It is effective for

In addition, the composition for cleaning the human body according to the present invention may be prepared in a liquid, ointment, or solid state for proper formulation for ease of use. More specifically, the composition of the present invention may be contained in products for cleaning face, skin, or hair, such as makeup soap, body wash, face wash, shampoo, conditioner, or conditioner, but is not limited thereto.

In addition, the present invention provides a method of preparing a composition for human body cleaning with an improved antibacterial effect by increasing the skin adsorption rate of the Hubak extract by adding a fatty acid when preparing a composition for cleaning the human body containing the Hubak extract. In the above method, the fatty acid is bound to the Hubak extract to increase the amount of skin adsorption after washing, thereby remarkably increasing the antibacterial effect of the Hubak extract against body odor-causing bacteria and acne bacteria. The method may include a mixture in which the extract and fatty acids are mixed in a weight ratio of 1:10 to 50 (thick extract: fatty acid), and a fragrance having a ClogP value of 3 or more.

The composition for cleaning the human body of the present invention is excellent in inhibiting and removing the proliferation of microorganisms causing unpleasant odors such as liquid odor, foot odor, and head odor, and has excellent antibacterial activity against acne bacteria, so it is effective in treating acne, and has excellent reverberation properties. . In addition, since the composition for cleaning the human body of the present invention is made of natural ingredients and is safe for the human body, it can be used for maintaining and improving skin health regardless of age.

Hereinafter, examples, etc. will be described in detail to aid understanding of the present invention. However, the embodiments according to the present invention may be modified in various forms, and the scope of the present invention should not be construed as being limited to the following examples. The embodiments of the present invention are provided to more completely describe the present invention to those of ordinary skill in the art.

The inventors of the present invention are to dissolve the extract of Fubacco, which has the best antibacterial effect overall, in a fragrance having a ClogP value of 3 or more, and target fatty acids that are expected to have an emollient effect in the form of oil. To find out the effect, a certain amount of Hubak extract, fatty acids, and flavorings having a ClogP value of 3 or more were mixed by concentration, and then the residual skin concentration of the Hubak extract was measured to evaluate whether there was an antibacterial effect in the body cleaning substrate. As a result, when a mixture of Hubak extract, a fatty acid, and a fragrance having a ClogP value of 3 or more, a higher residual concentration of Hubak extract was confirmed when used alone, and a high antibacterial effect can be expected. In addition, it was surprisingly found that the feeling of use is also excellent due to the emollient action and reverberation effect of the oily fatty acid.

Preparation Example: Preparation of Humpback Extract

_{The dried thick bark was pulverized and subjected to supercritical extraction of CO 2} under a pressure of 10 to 30 mpa at a temperature of 30 to 60° C., and the extract was used after vacuum drying.

Experimental Example 1: Evaluation of antimicrobial activity of various components, including the extract of hush

The present inventors first evaluated the antibacterial effect against major dermatophytes, liquid odors, and acne bacteria with the Paper Disc method, targeting about a hundred kinds of fungicides known to have antibacterial effects in the field of household goods and cosmetics. And, among the evaluation targets, in order to evaluate the exact antimicrobial activity for species with excellent antimicrobial efficacy, the minimum inhibitory concentration (MIC) for each bacteria was determined using the two fold dilution method. It measured and the results are shown in Table 1 (unit: ppm) below. As test strains, the skin flora Staphylococcus epidermidis , odor causative bacteria Corynebacterium xerosis , and acne bacteria Propionibacterium acnes were targeted. Tested. In the MIC measurement method, an antimicrobial sample is diluted in a liquid medium at regular concentration intervals, or added to a sterilized solid medium at regular concentration intervals to solidify, and then the pre-cultured test bacteria are inoculated into the liquid medium, or a platinum dose is taken on the solid medium. After smearing, the cells were incubated at 37°C for 24 hours, and then the degree of growth of the cells according to the sample concentration was observed.

Test substance S.epidermidis C.xerosis Propionibacterium acnes Black pepper extract 0.1 0.5 6.0 Triclosan 0.1 1.0 7.8 Triclocarban 5.0 8.0 39.0 Xantorazole 8.0 3.0 39.0 Berberine 30.8 3.0 78.0 Tea tree oil 62.5 7.8 625.0 Zincidone 62.5 78.0 625.0 Coopergluconate 500.0 78.0 625.0 Bisabolol 500.0 625.0 6250.0 Sophora extract 500.0 78.0 500.0 Chitin 500.0 625.0 7813.0

As a result of the test, the extract of Hubak extract showed the best antibacterial activity overall, and triclosan, trichlorocarban, berberin, or xanthorrhizol showed excellent antibacterial activity. In particular, Corynebacterium xerosis , which is known to be found in many owners with a strong odor due to an unpleasant odor that irritates the nose, is expected to have excellent antibacterial activity compared to triclosan, and thus have specificity in this strain.

Preparation of Examples 1 to 6 and Comparative Examples 1 to 4

According to the ingredients and contents shown in Table 2 below, first, the extract and fatty acids are dissolved in a fragrance solution having a ClogP value of 3 or more, and if the formulation is liquid, put it in a human body cleaning material, and then use a general mechanical or homomixer, etc. Mixing uniformly using a stirrer, and in the case of solid cosmetic soap, soap bases (Soap Noodles) were mixed with liquid additives using a conventional soap manufacturing apparatus, and molded through molding and extrusion processes, and Example 1 A composition for cleaning the human body of ~ 6 and Comparative Examples 1 to 4 was prepared.

As the body cleaning material, a cleaning base in which an appropriate amount of one or more kinds of purified water was mixed with an alkali salt of a higher fatty acid, a surfactant, a wetting agent, a sequestering agent, and purified water was used.

unit:
weight% Solid cosmetic soap composition Liquid-type human body cleansing composition Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Example 4 Example 5 Example 6 Comparative Example 3 Comparative Example 4 Soap Noodles
(manufacturer:
Wilmar) To 100 To 100 To 100 To 100 To 100 - - - - - Potassium laurate/myristate - - - - - 5 10 20 5 10 Cocamidopropylbetaine - - - - - 25 20 10 25 20 glycerin - - - - - 5 10 15 5 10 Tetrasodium EDTA - - - - - 0.5 0.3 0.2 0.5 0.3 Purified water - - - - - To100 To 100 To 100 To 100 To 100 Black pepper extract 0.05 0.2 0.5 0.005 0.2 0.03 0.1 1.0 0.003 0.1 Palm Oil/Palm Nuclear Oil Fatty Acid (Manufacturer: Pacific Oleo) 1.0 5.0 20.0 5.0 - 1.0 2.0 30.0 0.5 - Spices
(ClogP 3.0 or higher) 0.5 2.0 3.0 0.5 2.0 0.5 2.0 3.0 0.5 2.0

Experimental Example 2: Measurement of adsorption amount of thick-baked extract

In order to evaluate the skin adsorption amount of Hubak extract for the human body cleaning compositions of Examples 1 to 6 and Comparative Examples 1 to 4, distilled water was added to the first prepared body cleaning composition to prepare a solution having a concentration of 10% and used as a sample. First, secure the skin of the same area from a hairless mouse (5~7 weeks old, male), place the stratum corneum upward on the adsorption cell, remove the hair with a sharp knife, and then set the adsorption cell in a shaker. placed on the (shaker). After 30 g of the test substance was added to the upper part of the adsorption cell, the shaker was operated at a speed of 120 rpm for 30 seconds to cause physical contact between the test substance and the skin. At this time, the area of the skin in contact is 10cm ² . Immediately, the adsorption cell was tilted to immediately decant the test material, and the cell was turned over for 30 seconds to remove the fluidized bed. After adding 50 g of purified water at 25° C., the fluidized bed was removed by shaking at a speed of 120 rpm for 30 seconds and tilting the adsorption cell. This washing process was repeated 5 times in the same way. After separating and spreading the skin, cut the skin into the same size using a biopsy punch with a diameter of 10 mm, put 5 pieces in a test tube, add 1 g of ethanol, and leave for 24 hours to sufficiently elute and vortexing. ), filtering (filtering) was carried out by using a liquid chromatograph method to quantitative analysis of the extract. The hairless mice used were subjected to three per sample to obtain an average value, and the adsorption amount per unit area (ug/cm ² ) and the skin adsorption rate of the following formula 2 were obtained, and the results are shown in Table 3.

Unit: Adsorption amount ug/cm ² Solid cosmetic soap composition Liquid-type human body cleansing composition Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Example 4 Example 5 Example 6 Comparative Example 3 Comparative Example 4 Initial adsorption 17.5 40.5 53.7 1.5 36.5 11.4 25.5 71.5 10.9 22.5 Amount of adsorption after washing once (skin adsorption rate) 12.0
(68.6%) 28.9
(71.4%) 35.2
(65.5%) 0.8
(53.3%) 17.5
(47.9%) 7.5
(65.8%) 18.9
(74.1%) 51.2
(71.6%) 6.1
(56.0%) 10.9
(48.4%) Amount of adsorption after washing 5 times (skin adsorption rate) 10.0
(57.1%) 23.2
(57.3%) 29.3
(54.6%) 0.6
(40.0%) 13.7
(37.5%) 6.3
(55.3%) 15.2
(59.6) 39.5
(55.2%) 4.4
(40.4%) 8.7
(38.7%)

Looking at the above results, compared to Comparative Examples 1 to 4, in Examples 1 to 6, in which the mixture of Hubak extract, fatty acid, and ClogP 3 or more in a weight ratio of 1:10:5 to 1:50:25, adsorption of the Hubak extract after washing The amount was relatively excellent.

Experimental Example 3: Liquid odor and microbial inhibition clinical test

After using the composition for cleaning the human body of Examples 2 and 5 and Comparative Examples 2 and 4 directly on the armpit, the degree of antibacterial and deodorant was evaluated. For antibacterial, the number of microorganisms collected from the armpit was measured using an Easy stamp, and the degree of deodorization was evaluated by directly smelling the odor from the armpit. Each detailed description is as follows.

(Selection of subject and test protocol)

Twenty adult men over 20 years of age who feel that they have a lot of sweat or the odor of their armpits is self-consciously or intentionally. It was limited to those who agreed not to use products that may affect the test, such as cosmetics and perfumes, in the evaluation site. Before the start of the evaluation, the number of bacteria and odor in the armpit were measured and used as a baseline after product use. The evaluation period was 2 weeks, and Examples 2 and 5 were used on one side and Comparative Examples 2 and 4 on the other side, respectively, with the left and right sides symmetrically, and 10 people were carried out by randomly changing the left and right positions of the product. The use was visited once every day during the test period to take a shower at the same time, and after the last use once a week, 4 hours elapsed, and microbial measurement and odor evaluation were performed (armpit microbial count).

Using Easy stamp TPC (Komed, Korea), the number of microorganisms was measured by collecting directly from the armpit. To use, 1) bend the lid up and down one by one so that the lid does not come off, 2) record the subject name and date, 3) open the lid of the easy stamp and lightly press the concave part of the armpit, 4) the lid After checking whether it is well closed, it was placed in an incubator at 37°C and incubated for more than 24 hours. As a result, the number of colonies formed according to the method shown in Table 4 was determined as 0-5 points according to the scoring scale, and the average value was obtained by comparing with the number of colonies measured before the test.

score Evaluation standard 0
One
2
3
4
5 less than 30 colonies
30-300 colonies (30-300 colonies)
> 300 colonies. Colonies distinct (more than 300, but clear distinction between colonies)
Some but all colonies fused
Growth not completely confluent (only part of colonies are separated)
Confluent growth (no distinction between colonies)

The experimental results are shown in Table 5 below.

Solid cosmetic soap composition Liquid-type human body cleansing composition Example 2 Comparative Example 2 Example 5 Comparative Example 4 Before use
(Baseline) 3.85 3.78 3.89 3.87 after use
(Reduction rate) 1.48
(62.9%) 2.32
(38.6%) 1.32
(66.1%) 2.35
(39.3%)

From the above results, it can be seen that in Examples 2 and 5, the number of microbial colonies was significantly reduced compared to Comparative Examples 2 and 4.

Experimental Example 4: Measurement of odor intensity

Five well-trained sensory evaluation specialists conducted a sniff test in which the odor intensity of the armpits was directly detected. The evaluation was conducted in a ventilated constant temperature and humidity room, and the smell was directly sniffed within 10 cm from the armpit. The results were 0-5 points according to the scoring scale shown in Table 6 below, and the average value was calculated by comparing with the measurement accuracy before the test.

score Evaluation standard 0
One
2
3
4
5 No smell at all
Very weak smell
Weak smell
Smell is usually
Strong smell
Very strong smell

The experimental results are shown in Table 7 below.

Makeup soap composition Liquid-type human body cleansing composition Example 2 Comparative Example 2 Example 5 Comparative Example 4 Before use
(Baseline) 3.95 3.89 3.82 3.87 after use
(Reduction rate) 1.57
(60.3%) 2.43
(37.5%) 1.49
(61.0%) 2.41
(37.7%)

From the above results, it was found that Examples 2 and 5 prepared according to the present invention had a remarkable effect on reducing body odor compared to Comparative Examples 2 and 4.

As a result, the composition for cleaning the human body of the present invention (Examples 2 and 5) contained palm oil/palm kernel oil together with the extract of husks, thereby inhibiting the reproduction of microorganisms and body odor compared to Comparative Examples 2 and 4 not containing palm oil/palm kernel oil. It was confirmed that the inhibitory effect was remarkably excellent.

Experimental Example 5: Clinical trial for improving acne

In order to evaluate the clinical effect on the prevention and treatment of acne in Examples 2 and 5 and Comparative Examples 1 and 3, the following experiment was conducted.

First, 10 male experimental groups (using Examples 2 and 5) and 10 each of the control groups (using Comparative Examples 1 and 3) were selected as test subjects, twice a day, for 2 weeks. We evaluated the effect of preventing and improving acne by using the soap provided. The determination method is to determine the effect of reducing comedones according to the criteria shown in Table 8 below through visual observation after a certain grade is given according to the condition of acne before the start of the experiment, and then the grade for acne of the clinical trial subject is reduced by 3 or more. When it shows excellent effect, if it shows a decrease of 1 to 2, it is determined that the effect is intermediate, if there is no decrease, it is not effective, and if the grade after the test is higher than the grade before the test, it is judged to be deteriorated, and the results are shown in Table 8.

score state 0
One
2
3
4
5
6
7
8
9 Normal state
The number or size of comedones is very small or inflammation has not progressed
The number or size of comedones is moderately inflamed
Comedones with a small number of inflammatory papules
Small, extensive nodules and inflammatory comedones are present
Small number and size of papular nodules present
Moderate inflammatory nodules present
The presence of a large number of inflammatory nodules
Presence of severe nodular comedones
Severe cysts and inflammatory nodules present

The experimental results are shown in Table 9 below.

Excellent effect Middle effect no effect Worsened Skin side effects system Example 2 5 people 4 people 1 person 0 people 0 people 10 people Example 5 6 people 4 people 0 people 0 people 0 people 10 people Comparative Example 1 3 people 3 people 3 people 1 person 0 people 10 people Comparative Example 3 3 people 4 people 2 people 1 person 0 people 10 people

As shown in Table 9, the composition for cleaning the human body containing 0.2% by weight (Example 2) or 0.1% by weight (Example 5) of the red pepper extract contained 0.005% by weight (Comparative Example 1) or 0.003% by weight of the red pepper extract. (Comparative Example 3) It was found that the acne improvement effect was remarkably superior to that of the composition for cleaning the human body containing.

Through the above four experiments, it was confirmed that the composition for cleaning the human body containing the extract, fatty acid, and fragrance having a ClogP value of 3 or more according to the present invention exhibits a strong antibacterial effect on body odor and acne bacteria. In addition, it was confirmed that the composition can be used in a small amount due to its high degree of skin adsorption even after washing, has few side effects to the skin, and can effectively maintain and improve skin health by imparting an emollient effect.

Claims (12)

Including a scented extract, a fatty acid, and a fragrance having a ClogP (octanol-water partition coefficient) value of 3 or more according to the following Equation 1,
[Equation 1]

A composition for cleaning the human body comprising a mixture in which the extract and fatty acids are mixed in a weight ratio of 1:10 to 50 (thick extract: fatty acid). The composition for cleaning the human body according to claim 1, wherein the fume extract is contained in an amount of 0.01 to 2% by weight based on the total weight of the composition. According to claim 1, wherein the fatty acid is lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, C8-20 carboxylic acid including linoleic acid; Fatty acids derived from vegetable oils including palm oil, palm kernel oil, soybean oil, rapeseed oil, corn oil, rapeseed oil, sunflower oil, safflower oil, cottonseed oil, sesame oil, rice bran oil, camellia oil, castor oil, olive oil, and palm oil; Fatty acids derived from animal fats including tallow, pork fat, sunny fat, fish oil, whale oil, and tuna oil; A composition for cleaning a human body comprising at least one selected from the group consisting of fatty alcohol, mineral oil, and paraffin. The composition for cleaning a human body according to claim 1, wherein the fatty acid is contained in an amount of 1 to 30% by weight based on the total weight of the composition. The composition for cleaning a human body according to claim 1, wherein the fragrance having a ClogP value of 3 or more is contained in an amount of 0.1 to 5% by weight based on the total weight of the composition. The composition for cleaning a human body according to claim 1, wherein the composition comprises 0.01 to 2% by weight of the fume extract and 1 to 30% by weight of the fatty acid based on the total weight of the composition. delete According to claim 1, wherein the composition is a fragrance having a value of 3 or more of ClogP (octanol-water partition coefficient) according to the following Equation 1, 1:10:5 to 1: A composition for cleansing the human body comprising a mixture mixed in a weight ratio of 50:25 (fume extract: fatty acid: fragrance).
[Equation 1]

The composition for cleaning a human body according to claim 8, wherein the mixture is contained in an amount of 1 to 35% by weight based on the total weight of the composition. The composition for cleaning the human body according to claim 1, wherein the composition has antibacterial activity against Corynebacterium xerosis and Propionibacterium acnes. In the manufacture of a composition for cleaning the human body containing the extract,
In the method for preparing a composition for cleaning the human body with improved antibacterial effect by increasing the skin adsorption rate of the extract from the husks by adding additional fatty acids,
The composition for cleaning the human body is a mixture of 1:10 to 50 (thick extract: fatty acid) in a mixture of thick peel extract and fatty acid, and ClogP (octanol-water partition coefficient) according to Equation 1 below. A method for producing a composition for cleaning a human body comprising a fragrance having a value of 3 or more.
[Equation 1]

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