JP2021059520A - External composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To coexist with a heparinoid and one or more selected from 1,3-propanediol, arcandiol having 5 to 10 carbon atoms and amphipathic components, and it is good without stickiness. Provided is an external composition having a feeling of use and appearance (transparency). An external composition containing (A) a heparinoid; B) 1,3-propanediol, an arcandiol having 5 to 10 carbon atoms, and one or more selected from amphipathic components. To prepare. [Selection diagram] None

Description

The present invention relates to an external composition. More specifically, the present invention relates to an external composition containing a heparinoid.

Heparinoids are one of the acidic mucopolysaccharides and are widely used as active ingredients of external preparations because they have excellent moisturizing action, anti-inflammatory action, blood circulation promoting action and the like.

For example, Patent Document 1 proposes a composition for external use on the skin, which comprises a heparinoid, a carboxyvinyl polymer and / or a salt thereof, and xanthan gum.

Further, in Patent Document 2, an external composition containing (A) a phosphocholine group-containing polymer, (B) hydroxypropyl methyl cellulose, and (C) a heparin-like substance. Has been proposed.

Japanese Unexamined Patent Publication No. 2000-302664 JP-A-2018-302664

As described above, various formulations containing heparin-like substances have been developed in order to effectively exert various effects of heparin-like substances. These formulations are sufficient to impart the various pharmacological effects of heparinoids (treatment and prevention of atopic dermatitis, hypertrophic scars and keloids, post-traumatic care (bruise, sprain, contusion, etc.)). However, since there are concerns about stickiness and irritation peculiar to mucopolysaccharides, it has been a problem to obtain a good feeling of use, especially with a lotion agent. Further, in a liquid composition such as a lotion agent, various feelings of use such as refreshing and moist are required depending on the purpose, but for any purpose, feelings of use such as stickiness and irritation tend to be avoided. Further, in the liquid composition, the appearance of the preparation is one of the important factors as well as the usability, and in order to give a particularly fresh appearance, a preparation having a transparent to translucent appearance has been required.

Therefore, from the above circumstances, it has been an issue to obtain a transparent external composition having a good feeling of use (non-stickiness) and an appearance (transparency) while having various effects of a heparinoid. Furthermore, an object of the present invention is to provide a transparent external composition having excellent stability.

As a result of diligent studies to solve the above problems, the present inventors have conducted diligent studies.
By coexisting with (A) a heparinoid; and (B) 1,3-propanediol, an arcandiol having 5 to 10 carbon atoms, and one or more selected from amphipathic components, it becomes sticky. It has been found that the composition is for external use and has a good feeling of use and appearance (transparency). Furthermore, they have found that high stability (pH, coloring, transparency) can be ensured even under severe conditions of high temperature and light irradiation, and have completed the present invention.

That is, the present invention provides the following external composition.
Item 1.
(A) Heparinoid;
(B) An external composition containing 1,3-propanediol, an arcandiol having 5 to 10 carbon atoms, and one or more selected from amphipathic components.
Item 2.
Item 2. The external composition according to Item 1, wherein the content of the component (A) is 0.01 to 5% by mass.
Item 3.
The component (B) is 1,3-propanediol, arcandiol having 5 to 10 carbon atoms, decaglyceryl (eicosane diacid / tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylic acid, and succinic acid. One or 2 selected from the group consisting of diethylhexyl, diethoxyethyl succinate, polyoxyalkylene glyceryl ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene alkyl ether, and polyoxyalkylene alkyl glucoside. Item 2. The external composition according to Item 1 or 2, which is more than a species.
Item 4. The component (B) is 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, cyclohexanedicarboxylic acid bisethoxydiglycol, polyoxybutylene polyoxyethylene polyoxy. Propylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene methyl glucoside and polyoxypropylene Item 3. The external composition according to Item 3, wherein the composition is one or more selected from the group consisting of methyl glucoside. Item 5. Item 2. The external composition according to any one of Items 1 to 4, further containing one or more selected from the group consisting of the component (C) glycyrrhizate, a water-soluble ascorbic acid derivative, and tranexamic acid. Item 6. The component (C) is dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid glucoside, Item 2. The external composition according to Item 5, which contains one or more selected from the group consisting of tranexamic acid. Item 7. Item 2. The external composition according to any one of Items 1 to 6, further containing the component (D) liquid oil. Item 8. Item 2. The external composition according to any one of Items 1 to 7, wherein the external composition is liquid. Item 9. The external composition according to any one of Items 1 to 8, wherein the external composition has a viscosity of 10 to 10000 mPa · s. Item 10. Item 2. The external composition according to any one of Items 1 to 10, wherein the external composition has a transparent to translucent appearance.

The external composition of the present invention is one or more selected from (A) heparinoid; and (B) 1,3-propanediol, arcandiol having 5 to 10 carbon atoms, and a parent medium component. By coexisting with and, it is possible to provide an external composition which is not sticky, has a good usability and appearance (transparency), and can secure higher stability (pH, coloring, transparency).

Embodiments of the present invention will be described in detail. However, the present invention is not limited to the following embodiments.

In the present specification, the unit of content "mass%" is synonymous with "g / 100g".

The external composition of the present invention comprises one or more selected from (A) heparinoids, (B) 1,3-propanediols, arcandiols having 5 to 10 carbon atoms, and amphipathic components. Contains.

[(A) Heparinoid]
The heparinoid contained in the external composition of the present invention means a general term for polysulfated mucopolysaccharides such as chondroitin polysaccharide, and has an average of 0.5 〜 5 molecules per monosaccharide constituting the mucopolysaccharide. , Preferably having an average of 0.6 〜 3 molecules of sulfate. More specifically, the heparinoid contains heparin, chondroitin sulfate D called chondroitin polysulfate, chondroitin sulfate E, and the like.

Heparinoids can also be obtained by sulfated mucopolysaccharides, extracted and purified from the internal organs containing the bronchi of animals such as cattle and pigs using an aqueous carrier, and then sulfated as needed. You can also get it by doing things. Since heparinoids have been developed as raw materials for pharmaceuticals or cosmetics, such commercial products can also be used.

In the external composition of the present invention, as the heparinoid, those contained in the Japanese Pharmacopoeia non-pharmaceutical standard are preferably used.

In the external composition of the present invention, the content of the component (A) with respect to the total amount of the composition is appropriately set according to the type and content of other compounding components, the formulation form, the method of use and the like. It is preferably 0.005% by mass or more, more preferably 0.001% by mass or more, still more preferably 0.01% by mass or more, and particularly preferably 0.1% by mass or more.
The content of the heparinoid is preferably 10% by mass or less, more preferably 5% by mass or less, still more preferably 1% by mass or less, and particularly preferably 0.5% by mass, based on the total amount of the composition. It is as follows.
The content of the heparinoid is preferably 0.005 to 10% by mass, more preferably 0.001 to 5% by mass, still more preferably 0.01 to 1% by mass, based on the total amount of the composition. Particularly preferably, it is 0.1 to 0.5% by mass.

[(B) 1,3-Propanediol, arcandiol having 5 to 10 carbon atoms, and amphipathic component]
As the component (B) of the present invention, 1,3-propanediol, an arcandiol having 5 to 10 carbon atoms, and an amphipathic component are included in the liquid external composition. By blending the component (B) together with the component (A), a liquid external composition having both a good usability without stickiness and stability of the preparation is provided even when a heparinoid is blended. It becomes possible. For example, 1,3 propanediol, arcandiol having 5 to 10 carbon atoms, decaglyceryl (eicosane diacid / tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylic acid, diethylhexyl succinate, di succinate. Examples thereof include ethoxyethyl, polyoxyalkylene glyceryl ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene alkyl ether, and polyoxyalkylene alkyl glucoside.

As the component (B) of the present invention, any one of these compounds or a combination of two or more of these compounds can be used. Among them, 1,3 propanediol and arcandiol having 5 to 8 carbon atoms are used. One or more selected from the group consisting of bisethoxydiglycol cyclohexanedicarboxylic acid, polyoxyalkylene glyceryl ether, polyoxyalkylene alkyl ether and polyoxyalkylene alkyl glucoside is preferable.
1,3 propanediol, 1,2 pentanediol, 1,2 hexanediol, 1,2 octanediol, bisethoxydiglycol cyclohexanedicarboxylic acid, polyoxybutylene polyoxyethylene polyoxypropylene glyceryle One or more selected from the group consisting of -tel, polyoxyethylene polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene alkyl ether, and polyoxyethylene methyl glucoside and polyoxypropylene methyl glucoside. More preferably, 1,3 propanediol, 1,2 pentanediol, 1,2 hexanediol, bisethoxydiglycol cyclohexanedicarboxylic acid, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, poly Selected from the group consisting of oxyethylene polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene decyl tetradecyl ether, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene methyl glucoside and polyoxypropylene methyl glucoside. One kind or two or more kinds are more preferable.

The arcandiol having 5 to 10 carbon atoms has preferably 5 to 8 carbon atoms, more preferably 5 to 6 carbon atoms, from the viewpoint of remarkably exerting the effect of the present invention. For example, one or more selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, and 1,2-octanediol is preferable, 1,2-pentaniole and 1 One or more selected from the group consisting of 2,2-hexanediol is more preferable, and 1,2-pentanediol is even more preferable. The commercially available products are not particularly limited, but are HYDROLLITE-5, HYDROLLITE-5 Green (manufactured by Symrise Co., Ltd.), KMO-6 (manufactured by Osaka Organic Chemical Industry Co., Ltd.), Microcare Emorient PTGJ, and Microcare Emorient HXD (THOR). Made) etc. can be used.

An amphipathic component is a compound in which both a hydrophilic group and a hydrophobic group (lipophilic group) are present in one molecule, and as a result, it has an affinity for both an aqueous phase and an oil phase (organic phase). Point to.

Such amphipathic components are not particularly limited, and examples thereof include divalent carboxylic acid esters and alkylene oxide derivatives.

The divalent carboxylic acid ester is a compound obtained by condensing a divalent carboxylic acid with a hydroxy group such as glycol or glycoleter, and is not particularly limited, but for example, (eicosanedioic acid / tetradecanedioic acid) polyglyceryl. -10, bisethoxydiglycol cyclohexanedicarboxylic acid, bis 1,4-cyclohexanedicarboxylic acid (triethyleneglycol monoethyl ether), bis adipate (diethylene glycol monoethyl ether), bis adipate (triethylene glyco-) Lumonoethyl ether), and diethoxyethyl succinate, diethylhexyl succinate, among which (eicosanedioic acid / tetradecanedioic acid) polyglyceryl-10, bisethoxydiglycol cyclohexanedicarboxylic acid, diethoxyethyl succinate, And one or more selected from the group consisting of diethylhexyl succinate, preferably one or more, consisting of diethoxyethyl succinate, polyglyceryl-10 (eicosandioic acid / tetradecanedioic acid), and bisethoxydiglycol cyclohexanedicarboxylic acid. One or more selected from the group is more preferable, and diethoxyethyl succinate and bisethoxydiglycol cyclohexanedicarboxylic acid are further preferable.
The commercially available products are not particularly limited, but are: diethoxyethyl succinate (CRODAMOL DES), diethylhexyl succinate (CRODAMOL OSU) (all manufactured by Kuroda Japan Co., Ltd.), Neosolue-Aqua, Neosolue-AquaS. ((Eikosandioic acid / tetradecanedioic acid) polyglyceryl-10) and Neosolue-Aquolio (cyclohexanedicarboxylic acid bisethoxydiglycol) (both manufactured by Nippon Seika Co., Ltd.) can be used.

The alkylene oxide derivative used in the present invention is a polymer of a specific alkylene glycol or a compound obtained by adding a specific alkylene oxide group to a specific hydroxy compound.

In the alkylene oxide derivative used in the present invention, from the viewpoint of significantly exerting the effect of the present invention, polyoxyalkylene glyceryl ether, polyoxyalkylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyalkylene sorbitol, poly Oxyalkylene erythritol ether, polyoxyalkylene pentaerythritol ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene trimethyl propane, polyoxypropylene glycol, polyoxyethylene polyoxypropylene Glycol, polyoxyalkylene xylitol, polyoxyalkylene dipentaerythritol, polyoxyalkylene innocitol, polyoxyalkylene sorbitol, polyoxyalkylene trehalo ether, poly Oxyalkylene multi-toll ether and the like can be mentioned.

Among them, the alkylene oxide derivatives are polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, and polyoxy. Butylene polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, Polyoxypropylene sorbit, polyoxyethylene sorbit, polyoxyethylene polyoxypropylene sorbit, polyoxypropylene erythritol, polyoxyethylene erythritol, polyoxyethylene pentaerythritol, poly Oxyethylene Polyoxypropylene Erythrite, Polyoxypropylene Pentaerythrite, Polyoxyethylene Polyoxypropylene Pentaerythrite, Polyoxybutylene Polyoxyethylene Pentaerythrite , Polyoxyethylene diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether, polyoxyethylene trime Tyrolean Propene, Polyoxypropylene Trimethylol Propane, Polyoxyethylene Polyoxypropylene Trimethylol Propene, Polyoxypropylene Glycol, Polyoxyethylene Polyoxypropylene Glycol, Polyoxybutylene Polyoxyethylene Polyoxypropylene Glyco , Polyoxyethylene xyl, polyoxypropylene alkylenexyl, polyoxyethylene polyoxypropylene xyl, polyoxyethylene polyoxypropylene dipentaerythrite, polyoxyethylene dipentaeryth Litor, Polyoxypropylene Pentaeryth Lith, Polyoxyethylene Inositol, Polyoxypropylene Inocitol, Polyoxyethylene Polyoxypropylene Inocitor, Polyoxyethylene Scroase, Polio Xypropylene Scroase, Polyoxyethylene Polyoxypropylene Square, Polyoxyethylene Trehalo-Sweet, Polyoxypropylene Trehalo-Sweet, Polyoxyethylene Polyoxypropylene Trehalo-Sweet One or more selected from the group consisting of -tel, polyoxyethylene multi-toll ether, polyoxypropylene multi-toll ether, and polyoxyethylene polyoxypropylene multi-toll ether. Preferably
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene Alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene sorbit, polyoxyethylene polyoxypropylene Pentaerythrite, polyoxypropylene pentaerythrite, polyoxyethylene pentaerythrite, polyoxybutylene, polyoxyethylene pentaerythrite, polyoxyethylene diglyceryler -Tel, Polyoxypropylene Diglyceryl Ether, Polyoxyethylene Polyoxypropylene Diglyceryl Ether, Polyoxybutylene Polyoxyethylene Polyoxypropylene Diglyceryl Ether, Polyoxyethylene Polyoxypropylene Trimethylol Propane, More preferably, one or more selected from the group consisting of polyoxypropylene glycol, polyoxyethylene polyoxypropylene glycol, and polyoxybutylene polyoxyethylene polyoxypropylene glycol.
Polyoxyethylene glyceryl ether, polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene Alkyl glucoside, polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, polyoxypropylene alkyl ether, polyoxyethylene polyoxypropylene alkyl ether, polyoxypropylene sorbit, polyoxyethylene polyoxypropylene sorbit, polyoxyethylene Diglyceryl ether, polyoxypropylene diglyceryl ether, polyoxyethylene polyoxypropylene diglyceryl ether, polyoxybutylene polyoxyethylene polyoxypropylene diglyceryl ether, polyoxypropylene glycol, poly More preferably, one or more selected from the group consisting of oxyethylene polyoxypropylene glycol and polyoxybutylene polyoxyethylene polyoxypropylene glycol.
One or more selected from the group consisting of polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether, polyoxypropylene alkyl glucoside, polyoxyethylene alkyl glucoside, and polyoxyethylene polyoxypropylene alkyl ether. Even more preferable.

The molecular weight of such an alkylene oxide derivative is not limited as long as the effect of the present invention is exhibited, but is preferably 200 or more, more preferably 300 or more, from the viewpoint of significantly exerting the effect of the present invention. More preferably, it is 400 or more.

The properties of the alkylene oxide derivative are not limited as long as the effects of the present invention are exhibited, but from the viewpoint of significantly exerting the effects of the present invention, the properties are preferably semi-solid (including paste) to liquid at 25 ° C. It is preferable that the component is.

Among the alkylene oxide derivatives, the polyoxyalkylene alkyl ether is preferably a polyoxyethylene component that is semi-solid (including polyethylene) to liquid at 25 ° C.

Among these alkylene oxide derivatives, polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether is preferably polyoxybutylene polyoxyethylene polyoxypropylene glyceryl ether (3BO) (8EO. ) (5PO) is preferable.

Among these alkylene oxide derivatives, the polyoxyalkylene alkyl glucoside is preferably one or more selected from the group consisting of polyoxyethylene methyl glucoside and polyoxypropylene methylglucoside, and polyoxypropylene methylglucoside (polyoxypropylene methylglucoside). One selected from the group consisting of 10PO), polyoxypropylene methylglucoside (20PO), polyoxyethylenemethylglucoside (10PO), polyoxyethylenemethylglucoside (20PO) or Two or more are more preferable.

Among these alkylene oxide derivatives, the polyoxyethylene polyoxypropylene alkyl ether is preferably polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene polyoxypropylene cetyl ether, or polyoxyethylene polyoxy. One or more selected from the group consisting of propylene decyltetradecyl ether is preferable, and polyoxyethylene polyoxypropylene butyl ether (17EO) (17PO), polyoxyethylene polyoxy. Propylene butyl ether (37 E.O.) (38 P.O.), Polyoxyethylene polyoxypropylene cetyl ether (10 E.O.) (8 P.O.), Polyoxyethylene polyoxypropylene decyltetradecyl Ether (30EO) (6PO), Polyoxyethylene polyoxypropylene decyltetradecyl Ether (20EO) (6PO), Polyoxyethylene polyoxypropylene decyltetradecyl One or 2 selected from the group consisting of ether (24EO) (13PO), polyoxyethylene polyoxypropylene decyltetradecyleter (10EO) (6PO). More than seeds are more preferred.

These alkylene oxide derivatives are Unilube 50MB-26 (polyoxyethylene polyoxypropylene butyl ether (17EO) (17PO)) and Unilube 50MB-168 (polyoxyethylene polyoxy). Propylene Butyl Ether (37E.O.) (38P.O.)), Unilube 50MB-11 (Polyoxyethylene Polyoxypropylene Butyl Ether (9E.O.) (10P.O.)), Unisafe 10P-8 (polyoxyethylene polyoxypropylene cetyl ether (10EO) (8PO)), Unirub MT-630B (polyoxyethylene polyoxypropylene decyltetradecyl ether) (30EO) (6PO)), Unirub 50MT-2200B (Polyoxyethylene polyoxypropylene decyltetradecyl ether (24EO) (13PO)), Unirub 20MT-2000B (Polyoxyethylene polyoxypropylene decyltetradecyl ether (24EO) (13PO)), Unirub MS-70K (Polyoxypropylene stearyl ether (15PO)) ), Uniol HS-1600D (polyoxyalkylene sorbit), Pronone # 208 (polyoxyethylene polyoxypropylene glycol (150EO) (35PO)), Pronon # 124P (polyoxyethylene (polyoxyethylene () 20) Polyoxypropylene (20) glycol), Uniol D-2000 (polypropylene glycol), Macbiobride MG-10E (polyoxyethylene methyl glucoside (10EO)), Macbiobride MG -20E (polyoxyethylene methyl glucoside (20EO)), Macbiobride MG-10P (polyoxypropylene methyl glucoside (10PO)), Macbiobride MG-20P (polyoxypropylene methyl glucoside (20P.)). O.)), Wilbride MG2070 (polyoxybutylene polyoxyethylene polyoxypropylene methyl glucoside), Unilube 5TP-300KB (polyoxyethylene polyoxypropylene pentaerythritol ether (5EO) (65P)) O.)); Unilube 50TG-32 (polyoxyethylene polyoxypropylene glyceryl ether (24EO) (24PO)), Wilbride S-753 (polyoxybutylene) Polyoxyethylene polyoxypropylene glyceryl ether (3B. O. ) (8EO) (5PO)), Uniox G-1200 (polyoxyethylene glycerin), Unilube DGP-700, Unilube DGP-950 (polyoxypropylene diglyceryl ether) (The above is manufactured by Nichiyu Co., Ltd.); SY-DP14, SY-DP9 (Polyoxypropylene diglyceryl ether) (The above is manufactured by Sakamoto Yakuhin Kogyo Co., Ltd.); Glyceryl ether), Neupol SP-750 (Polyoxyalkylene sorbitol ether), Neupol PE-68 (Polyoxyethylene polyoxypropylene glycol (160EO)) (30PO)), Newpole PE-78 (Polyoxyethylene polyoxypropylene glycol (150EO) (35PO)), Newpol GEP-2800 (Poly). Oxyethylene polyoxypropylene glyceryl ether (24EO) (24PO)) (above, manufactured by Sanyo Kasei Co., Ltd.); Emargen PP-290 (polyoxyethylene polyoxypropylene glycol (160EO) (30PO), manufactured by Kao Co., Ltd.); NIKKOL SG-G2424 (polyoxyethylene polyoxypropylene glyceryl ether (24EO) (24PO), NIKKOL SG-DTD630 (polyoxy) Ethylene polyoxypropylene decyl tetradecyl ether (30EO) (6PO) (all manufactured by Nikko Chemicals); GLUCAM P-10 (polyoxypropylene methyl glucoside (10PO)), GLUCAM P -20 (Polyoxypropylene methyl glucoside (20P.O.)) GLUCAM E-10 (Polyoxyethylene methyl glucoside (10P.O.)), GLUCAM E-20 (Polyoxyethylene methyl glucoside (20P.O.)) It is commercially available under names such as (above, manufactured by Loubrizol).

In the present invention, one type of alkylene oxide derivative may be used alone, or two or more types may be used in any combination.

In the external composition of the present invention, the total content of the component (B) is not particularly limited and is appropriately set according to the types of other compounding components and the like, but from the viewpoint of remarkably exerting the effect of the present invention. It is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 0.5% by mass or more, still more preferably 1% by mass or more, based on the total amount of the composition. ..
The total content of the component (B) is preferably 30% by mass or less, more preferably 20% by mass or less, still more preferably 15% by mass or less, still more preferably 10% by mass, based on the total amount of the composition. % Or less, most preferably 5% by mass or less.
The total content of the component (B) is preferably 0.01 to 30% by mass, more preferably 0.1 to 20% by mass, still more preferably 0.5 to 15% by mass, based on the total amount of the composition. Even more preferably, it is 0.5 to 10% by mass, and most preferably 0.5 to 5% by mass.

In the external composition of the present invention, the ratio of the total content of the component (B) to the component (A) is not particularly limited, but the component (B) is preferably 0. It is 01 to 50,000 parts by mass, more preferably 0.1 to 20,000 parts by mass, still more preferably 0.5 to 1000 parts by mass, and even more preferably 1 to 300 parts by mass.

In the external composition of the present invention, the content of 1,3-propanediol alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited.
The single content of 1,3-propanediol is preferably 0.001% by mass or more, more preferably 0.01% by mass or more, still more preferably 0.1, based on the total amount of the composition. By mass or more, even more preferably 0.5% by mass or more.
The content of 1,3-propanediol alone is preferably 20% by mass or less, more preferably 10% by mass or less, still more preferably 5% by mass or less, based on the total amount of the composition.
The single content of 1,3-propanediol is preferably 0.001% by mass or more to 20% by mass, more preferably 0.001 to 10% by mass, still more preferably, based on the total amount of the composition. Is 0.01 to 8% by mass, and even more preferably 0.1% to 5% by mass.

In the external composition of the present invention, the single content of 1,3 propanediol and / or arcandiol having 5 to 10 carbon atoms with respect to the total amount of the composition is not particularly limited as long as the effect of the present invention is exhibited.
The single content of the arcandiol having 5 to 10 carbon atoms is preferably 0.001% by mass or more, more preferably 0.001% by mass or more, still more preferably 0.% by mass, based on the total amount of the composition. It is 01% by mass or more, and more preferably 0.1% by mass or more.
The single content of the arcandiol having 5 to 10 carbon atoms is preferably 10% by mass or less, more preferably 5% by mass or less, still more preferably 3% by mass or less, based on the total amount of the composition. ..
The single content of the arcandiol having 5 to 10 carbon atoms is preferably 0.001 to 10% by mass, more preferably 0.001 to 7% by mass, still more preferably 0.001 to 7% by mass, based on the total amount of the composition. It is 0.01 to 5% by mass, and even more preferably 0.1% to 3% by mass.

In the external composition of the present invention, the content of bisethoxydiglycol cyclohexanedicarboxylic acid alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited.
The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 0.001% by mass or more, more preferably 0.005% by mass or more, still more preferably 0.% by mass, based on the total amount of the composition. It is 01% by mass or more, and more preferably 0.05% by mass or more.
The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 10% by mass or less, more preferably 8% by mass or less, still more preferably 5% by mass or less, based on the total amount of the composition. ..
The content of bisethoxydiglycol cyclohexanedicarboxylic acid alone is preferably 0.001 to 10% by mass, more preferably 0.005 to 8% by mass, still more preferably 0.005 to 8% by mass, based on the total amount of the composition. It is 0.01 to 5% by mass, and even more preferably 0.05% to 3% by mass.

In the external composition of the present invention, the content of the alkylene oxide derivative alone with respect to the total amount of the composition is not particularly limited as long as the effects of the present invention are exhibited.
The content of the alkylene oxide derivative alone is preferably 0.01% by mass or more, more preferably 0.1% by mass or more, still more preferably 1% by mass or more, based on the total amount of the composition.
The content of the alkylene oxide derivative alone is preferably 15% by mass or less, more preferably 10% by mass or less, still more preferably 8% by mass or less, based on the total amount of the composition.
The content of the alkylene oxide derivative alone is preferably 0.01 to 15% by mass, more preferably 0.1 to 10% by mass, still more preferably 1 to 1% by mass, based on the total amount of the composition. It is 8% by mass.

[(C) One or more selected from the group consisting of glycyrrhizate, water-soluble ascorbic acid derivative, tranexamic acid, and nicotinamide]
Further, as the component (C) of the present invention, one or more selected from the group consisting of glycyrrhizate, a water-soluble ascorbic acid derivative, and tranexamic acid can be contained in a transparent to translucent external composition. The component (C) is a component having various effects such as an anti-inflammatory effect and a whitening effect, but all of them are components that may be sticky. In the present invention, even if the component (C) is blended together with the component (A), a good usability can be maintained without stickiness.

The glycyrrhizinate is not particularly limited, and examples thereof include dipotassium glycyrrhizinate and monoammonium glycyrrhizinate, and dipotassium glycyrrhizinate is preferable.

The water-soluble ascorbic acid derivative is not particularly limited, and is, for example, sodium ascorbic acid ester, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid glucoside, isostearyl. Examples thereof include disodium ascorbic acid, glyceryl ascorbic acid, bisglyceryl ascorbic acid, alkyl glyceryl ascorbic acid, and among them, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O. One or more selected from the group consisting of -ethylascorbic acid and ascorbic acid glucoside is preferable, and ascorbic acid phosphate sodium, ascorbic acid phosphate magnesium, 3-O-ethylascorbic acid, ascorbic acid glucoside, 2 One or more selected from the group consisting of -O-ethylascorbic acid is more preferable.

Such component (C) is not particularly limited, but is, for example, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium ascorbic acid ester, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-. One or more selected from the group consisting of O-ethylascorbic acid, ascorbic acid glucoside, isostearyl ascorbic acid disodium, glyceryl ascorbic acid, bisglyceryl ascorbic acid, alkylglyceryl ascorbic acid, tranexamic acid, and nicotinic acid amide. Among them, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium ascorbic acid ester, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid glucoside, tranexamic acid. , One or more selected from the group consisting of nicotinic acid amide, preferably dipotassium glycyrrhizinate, sodium ascorbic acid ester, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O-ethyl. One or more selected from the group consisting of ascorbic acid, ascorbic acid glucoside, tranexamic acid, and nicotinic acid amide are more preferable.

In the transparent to translucent external composition of the present invention, the total content of the component (C) with respect to the total amount of the composition is preferably 0.001 to 10% by mass, more preferably 0.005 to 5% by mass, and further. It is preferably 0.01 to 3% by mass, and even more preferably 0.05 to 2% by mass.

In the transparent to translucent external composition of the present invention, the ratio of the total content of the component (C) to the component (A) is not particularly limited, but the component (C) is relative to 1 part by mass of the component (A). However, it is preferably 0.0001 to 5000 parts by mass, more preferably 0.01 to 100 parts by mass, and further preferably 0.1 to 20 parts by mass.

[(D) Liquid oil]
Further, as the component (D) of the present invention, one kind or two or more kinds of liquid oils can be contained in the external composition of the present invention. The liquid oil is a component that gives the preparation a fluffy feeling of use, a smooth feeling of use, and an appropriate moisturizing feeling. In the present invention, the component (D) can be contained in the external composition of the present invention to the extent that the transparency of the appearance is not impaired.

Further, the liquid oil component as the component (D) of the present invention refers to an oil component that exhibits a liquid state at 25 ° C. Such component (D) is not particularly limited, but for example, ester oil, vegetable oil, animal oil, oil-soluble vitamin, hydrocarbon oil, higher fatty acid, higher alcohol, alkylglyceryl ether, silico- Ester oil, fluorine oil, lanolin / lanolin derivative and the like can be mentioned. Specifically, with linear fatty acids such as diethyl sebacate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, butyl stearate, ethyl oleate, ethyl lino-ate, and isopropyl lino-late. Ester oil with lower alcohol; linear fatty acids such as cetyl caprate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, cetyl palmitate, stearyl stearate, decyl oleate, oleyl oleate, etc. Ester oil with linear higher alcohol; isostearyl laurate, isotridecyl myristate, isosetyl myristate, isostearyl myristate, octyldodecyl myristate, 2-ethylhexyl palmitate, isosetyl palmitate, isostearyl palmitate, Ester oils of linear fatty acids such as 2-ethylhexyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl oleate, octyldodecyl ricino-late and alcohol having a branched chain; ethyl isostearate, isostearic acid. Ester oil of a fatty acid having a branched chain such as isopropyl and a lower alcohol; cetyl 2-ethylhexarate, cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexarate, hexyl isostearate, 2-hexyldecyl isostearate. Ester oil of a fatty acid having a branched chain such as and a linear higher alcohol; ethylene glycol dioctanoate, ethylene glycol dioleate, propylene glycol caprylate, propylene glycol dicaprylate, di (capryl). Acid / capric acid) propylene glycol, propylene glycol dicaprate, dipropylene glycol dioleate, neopentylglycol dicaprate, neopentylglycol dioctanoate, glyceryl tricaprylate, tri2-ethylhexane Glyceryl acid, tri (capric acid / capric acid) glyceryl, glyceryl triisopalmitate, glyceryl triisostearate, tri (capric acid / capric acid / myristic acid / stearic acid) glyceryl, (ethylhexanoic acid / stearic acid / adipic acid) ) Glyceryl, Trimethylol Propane tri2-ethylhexanoate, Trimethylol Propane triisostearate, Pentaerytritor tetra2-ethylhexanoate, Pe tetraisostearate Ester oils of fatty acids such as entaerythritol and pentaerythrit tetra2-ethylhexanoate and polyvalent alcohols; octyldodecyl neopentate, isosetyl octaterate, isostearyl octanoate, 2-ethylhexyl isoperalgonate, dimethyloctane Ester oil of a fatty acid having a branched chain such as hexyldecyl acid, octyldodecyl dimethyloctanoate, 2-ethylhexyl isopalmitate, isosetyl isostearate, isostearyl isostearate, and octyldodecyl isostearate, and an alcohol having a branched chain. Ester oils having fatty acids such as lauryl lactate, myristyl lactate, cetyl lactate, octyldodecyl lactate, trioctyl citrate, triisocetyl citrate, trioctyldodecyl citrate, diisostearyl malate, trimethyl trimellitic acid; diethylhexyl succinate, Ester oils of dibasic acids such as diethoxyethyl succinate, dioctyl succinate, diisopropyl adipate, diisobutyl adipate, dioctyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate; abrana oil, avocado oil, almond oil , Olive oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, rice oil, safrawer oil, sunflower oil, soybean oil, evening primrose oil, corn oil, rapeseed oil, persic oil, Ester oils, palm kernel oils, castor oils, jojoba oils, grape seed oils, macadamia nut oils, meadowform oils, citric acid oils, palm oils, rosehip oils and other vegetable oils; liquid horse oil, Animal oils such as mink oil and liquid lanolin; dl-α-tocopherol, dl-α-tocopherol citrate, dl-α-tocopherol nicotinate, dl-α-tocopherol acetate, benzyl nicotinate, Oil-soluble vitamins such as ascorbyl tetra2-hexyldecanoate, retinol acetate, retinol palmitate, retinal propionate, etc .; liquid paraffin, light liquid isoparaffin, heavy liquid isoparaffin, liquid isoparaffin, polybuden, polyisobuden, Linear or branched hydrocarbon oils such as hydrogenated polyisobutene, squalane (including sugar-squalane), squalane, α-olefin oligomers, isohexadecane, isododecane; higher fatty acids such as oleic acid, isostearic acid; isostearyl alco Ester, octyldodecanol, hexyldecanol, etc. Higher alcohol; Alkyl glyceryl ether such as isostearyl glyceryl ether; Methylpolysiloxane, dimethylpolysiloxane, dimethylcyclopolysiloxane, decamethylcyclopentasiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, higher grade Silicone oils such as alcohol-modified silicone oils; fluorine oils such as fluoropolyether and perfluoroalkylethane silicones can be mentioned.

Further, as the component (D) of the present invention, hydrocarbon oil, ester oil, oil-soluble vitamins and vegetable oil are preferable from the viewpoint of remarkably exerting the effect of the present invention, and diethyl sebacate, isopropyl myristate, isopropyl palmitate, isopropyl palmitate, Ethyl oleate, cetyl palmitate, decyl oleate, oleyl oleate, octyldodecyl myristate, 2-ethylhexyl palmitate, isopropyl palmitate, isostearyl palmitate, octyldodecyl oleate, isostearyl isostearate, 2-ethylhexane Cetyl acid, propylene glycol caprylate, propylene glycol dicaprylic acid, propylene glycol di (caprylic acid / capric acid), propylene glycol dicaprate, dipropylene glycol dioleate, neopentylglycol dicaprate -L, neopentylglycol dioctanoate, glyceryl tricaprylate, glyceryl tri2-ethylhexanoate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, tri Trimethylol propane 2-ethylhexanoate, trimetyl propane triisostearate, pentaerythritol tetra2-ethylhexanoate, pentaerythritol tetraisostearate, pentaerythrit tetra2-ethylhexarate, octyl neopentaate Dodecyl, triethyl citrate, triisocetyl citrate, trimethyl trimellitic acid, diisopropyl adipate, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, abrana oil, avocado oil, almond oil, olive oil, kukui nut oil, sesame oil, Wheat germ oil, rice germ oil, rice bran oil, rice oil, safrawer oil, sunflower oil, soybean oil, evening primrose oil, corn oil, rapeseed oil, persic oil, palm oil, palm kernel oil, Himasi oil, jojoba oil, grape seed oil, macadamia nut oil, meadowform oil, menjitsu oil, palm oil, rose hip oil, dl-α-tocopherol, dl-α-tocopherol succinate, Dl-α-tocopherol nicotinate, dl-α-tocopherol acetate, benzyl nicotinate, ascorbyl tetra2-hexyldecanoate, retinol acetate, retinol palmitate, retinoyl propionate, liquid paraffin, Light liquid isoparaffin, heavy liquid isoparaffin, stream Selected from animal isoparaffin, squalane (including sugar squalane), α-olefin oligomer, oleic acid, isostearic acid, isostearyl alcohol, octyldodecanol, hexyldecanol, isostearyl glyceryl ether 1 Species or two or more are more preferred, liquid paraffin, liquid isoparaffin, α-olefin oligomer, propylene glycol caprylate, propylene glycol dicaprate, propylene glycol dicaprylate, neopentylglycol dicaprate, Glyceryl tricaprylate, glyceryl tri2-ethylhexanoate, glyceryl tri (capric acid / capric acid), glyceryl triisopalmitate, glyceryl triisostearate, trimethylolpropane tri2-ethylhexanoate, tri (capric acid / capric acid) / Myristic acid / stearic acid) Glyceryl, trimethylol propanate triisostearate, pentaerythritol tetra2-ethylhexanoate, pentaerythritol tetraisostearate, pentaerythrit tetra2-ethylhexanoate, avocado oil, Olive oil, sesame oil, soybean oil, evening primrose oil, jojoba oil, grape seed oil, macadamia nut oil, meadowform oil, dl-α-tocopherol, dl-α-tocopherol acetate, tetra 2 -Ascorbyl hexyldecanoate, retinal acetate, retinal palmitate, retinal propionate, isostearic acid, isostearic acid, octyldodecanol, isostearyl glyceryl ether are more preferred, liquid paraffin, Liquid isoparaffin, α-olefin oligomer, glyceryl tri2-ethylhexanoate, glyceryl tri (capric acid / capric acid) glyceryl, trimethylolpropane tri2-ethylhexanoate, tri (capric acid / capric acid / myristic acid / stearic acid) ) Glyceryl, evening primrose oil, jojoba oil, macadamia nut oil, meadowform oil, dl-α-tocopherol, dl-α-tocopherol acetate, ascorbyl tetra2-hexyldecanoate are even more preferred.

In the external composition of the present invention, the total content of the component (D) with respect to the total amount of the composition is preferably 0.0001 to 5% by mass, more preferably 0.0005 to 3% by mass, still more preferably 0.001. It is ~ 1% by mass, and even more preferably 0.01 to 0.5% by mass.

[Liquid external composition] In the present specification, the "liquid external composition" means that it is in a liquid state or a fluid state at 25 ° C. For example, as a formulation form, a solution, a suspension, an emulsion, a milky lotion, a gel, a liniment, a lotion, an air azole, a sheet prepared by impregnating a non-woven fabric with a chemical, a mist, or the like. Can be. Of these, liquid agents, emulsions, gel agents, lotion agents, sheet agents, air azole agents, and mist agents are preferable, and liquid agents, gel agents, lotion agents, sheet agents, and air azole agents. , Mist agent is more suitable.

[Viscosity] The external composition of the present invention preferably has a liquid dosage form having fluidity at 25 ° C., and is preferably used as a lotion agent. However, by adding a thickener, the viscosity is increased. But it may be. From this point of view, the viscosity (25 ° C.) of the transparent external composition of the present invention is not particularly limited, but is preferably 10 to 10000 mPa · s, more preferably 10 to 5000 mPa · s, and 50 to 1000 mPa · s. Even more preferably, 500 mPa · s or less is particularly preferable.

The viscosity (25 ° C.) in the present specification is measured with a single cylindrical rotary viscometer (Brookfield viscometer) in accordance with the viscosity measurement method described in the 17th revised Japanese Pharmacopoeia general test method. The viscosity of the product. Specifically, it refers to the value measured using TV-10M (manufactured by Toki Sangyo Co., Ltd.), and the selection of conditions such as rotor and rotation speed is based on the instruction manual of this machine, 25 Measure the viscosity at ° C.

A description of the single cylindrical rotational viscometer is given below. A single cylindrical rotational viscometer is a viscometer that measures the torque when a cylinder in a liquid is rotated at a constant angular velocity. The viscosity η of the liquid is calculated by the following formula by experimentally determining the apparatus constant KB using the standard solution for calibrating the viscometer in advance. η = KBX T / ω η: Viscosity of liquid (mPa · s) KB: Device constant (rad / cm ³ ) ω: Angular velocity (rad / s) T: Torque acting on the cylindrical surface ( ^10-7 N · m)

[Transparency] In the present specification, the "external composition having a good appearance (transparency)" means a "transparent to translucent external composition" whose visual appearance is transparent or translucent. is there. Further, when the solubilized component contains oil, the composition is obtained by solubilizing the solubilized component, and when the appearance is translucent, the composition is in a microemulsion (fine emulsified) state. It also includes being. The appearance of the external composition of the present invention is preferably transparent to translucent, and the solubilized component in the composition is preferably in a solubilized state.

Here, "transparent to translucent" preferably means that the absorbance at 630 nm is less than 0.3 as an index of transparency. The "absorbance" can be measured with a micropredator [for example, SH-9000, manufactured by Corona Electric Co., Ltd.] or the like. The lower the "absorbance", the higher the transmittance and the higher the transparency. In the "transparent to translucent external composition" of the present invention, the characters of the font 14 (black on a white background) described under the bottle when filled in a transparent glass bottle having a diameter of about 3 cm at a height of about 3 cm are displayed. Can be read. Among those with a translucent appearance, in the case of a microemulsion (fine emulsified) state, the appearance may be colorless to bluish white, but even in that case, the above absorbance and the appearance of characters are also judged. This makes it possible to determine whether or not the composition is in the category of "transparent to translucent external composition". Preferably, the absorbance at 630 nm is 0.1 to 0.3 and the characters appear clearly and sharply in the character discrimination test, and the absorbance at 630 nm is 0.05 to 0.1 and the characters appear. It is more preferable that the characters appear clearly and sharp in the discrimination test, and it is even more preferable that the absorbance at 630 nm is less than 0.05.

[Other ingredients]
In addition to the above-mentioned essential components, the external composition for skin of the present invention has an ultraviolet scattering agent, an ultraviolet absorber, and an ingredient having a DNA damage preventing and / or repairing effect in order to add other useful effects. Whitening ingredient, anti-inflammatory ingredient, refreshing agent, organic acid, anti-glycation ingredient, antibacterial ingredient, cell activating ingredient, astringent ingredient, antioxidant ingredient, anti-aging ingredient, moisturizing ingredient, polyvalent alcohol, keratin softening ingredient, Various components such as vitamins, blood circulation promoting components, sebum adsorbing components, peptides or derivatives thereof, amino acids or derivatives thereof may be blended in one type or in combination of two or more. The respective components are not particularly limited as long as they can be used in the fields of pharmaceuticals, quasi-drugs, cosmetics, etc., and any one can be appropriately selected and used. In addition, those corresponding to the following plurality of components can be added as components having any effect among them.

Examples of the ultraviolet scattering agent include inorganic compounds such as zinc oxide, titanium oxide, iron oxide, cerium oxide, zirconium oxide, titanium silicate, zinc silicate, silicic anhydride, cerium silicate, and hydrous silicic acid, and the like. Inorganic compounds are coated with inorganic powders such as hydrous silicic acid, aluminum hydroxide, mica and talc, compounded with resin powders such as polyamide, polyethylene, polyester, polystyrene and nylon, and silicone oil. And those treated with fatty acid aluminum salt and the like.

The ultraviolet absorber is not limited, but is preferably a salicylic acid-based ultraviolet absorber, a silicic acid-based ultraviolet absorber, a benzoylmethane-based ultraviolet absorber, an benzoic acid ester derivative ultraviolet absorber, a triazine derivative ultraviolet absorber, and the like. It may be a benzalmalonate derivative UV absorber, an octocrylene-based UV absorber, an imidazole sulfonic acid derivative UV absorber, a benzophenone derivative UV absorber, or the like.

Further, these ultraviolet scattering agents and ultraviolet absorbers may be compounded, supported or encapsulated in another component, and the combination thereof is not particularly limited.

Ingredients that have the effect of preventing and / or repairing DNA damage include, for example, components derived from animals (eg, artemia); components derived from plants (eg, cat's claw); DNA, DNA salts, RNA, RNA. Nucleic acid components such as salts can be mentioned.

Examples of whitening ingredients include nicotinic acid amide; placenta; arbutin; ascorbic acid; ellagic acid; phytic acid; tranexamic acid; lucinol; chamomile ET; hydroquinone, 4-methoxysalicylic acid potassium salt; linoleic acid and its derivatives. Ascorbic acid and its salts, vitamin Cs such as ascorbic acid derivatives (sodium ascorbic acid ester, magnesium ascorbic acid phosphate, ascorbic tetra2-hexyldecanoate, 2-O-ethylascorbic acid, 3-O-ethyl Ascorbic acid, ascorbic acid glucoside, isostearyl ascorbic acid disodium, dipalmitate L-ascorbyl, ascorbyl palmitate trisodium, glyceryl ascorbic acid, bisglyceryl ascorbic acid, alkyl glyceryl ascorbic acid, etc.), Vitamin A or its Examples thereof include derivatives, pantothenic acid or vitamins such as derivatives thereof. Further, a plant component having a whitening effect may be used as a whitening component, and such plant components include iris (iris), almond, aloe, acerola, oolong tea, ages, Japanese persimmon, Japanese persimmon, Japanese persimmon, and persimmon. , Seaweed, Kakkon, Kiwifruit, Kujin, Chlorella, Rice, Rice Haiga, Oryzanol, Rice bran, Saishin, Sansho, Persimmon, Shakuyaku, Senkyu, Souhakuhi, Soybean, Natto, Tea, Touki, Tokinsenka, Hamamelis, Benibana, Buttonpi , Yokuinin, Asenyaku, Kaki (Diospyros kaki), Kiwi, Kuromame, Gentiana, Genjin, Sage, Daikon, Tsutsuji, Parsley, Hiiragi, Hop, Thyme, Chouji, Chinpi, Kanzo, Kamitsure, Prune, Shimotsukesou, Murasakikibu , Soybean, Grave fruit, Spike, Lemon, Kiwi, Pine, Nem, Artichoke, Sugina, Oobaku, Mematsuyoigusa, Bilberi, Himefuuro, Akkesiso, Seiyoushiroyanagi, Yukinoshita, Tsubokusa, Rozumari Ingredients derived from −, lavender, etc. can be mentioned. When these plant components are used in the external composition of the present invention, the form of the plant components is not particularly limited, but they can usually be used in the form of a plant extract (plant extract), an essential oil, or the like. The names in parentheses described in the plant components are the scientific name, alias or crude drug name of the plant.

When the whitening ingredient described above is added to the external composition of the present invention, the content thereof can be appropriately selected in consideration of the feeling of use on the skin and the effect, but for example, about the total amount of the external composition. It is 0.0003 to 10% by mass, preferably about 0.01 to 5% by mass. When a plant extract is used, the content is, for example, about 0.00001 to 20% by mass, preferably about 0.0001 to 15% by mass, based on the total amount of the external composition in terms of an extract such as an extract. More preferably, it is 0.001 to 10% by mass.

Examples of the anti-inflammatory component include allantin, caramine, tranexamic acid, glycyrrhizinic acid or a derivative thereof or a salt thereof (for example, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, etc.), glycyrrhetinic acid or a derivative thereof or a salt thereof (for example, for example. Glycyrrhetinic acid, stearyl glycyrrhetinate, etc.), zinc oxide, aminocaproic acid, azulene and its derivatives (eg, guaiazulene, azulene, etc.), tocopherol acetate, pyridoxin hydrochloride, menthol, camphor, terepine oil, indomethacin, salicylic acid or its derivatives. Derivatives, steroids or derivatives thereof or salts thereof (eg, hydrocortisone, prednisolone), ufenamate, bufexamac, ibprofenpiconol, glycolyl salicylate, plants (eg, confrey, auren, dokudami) Ingredients, etc. may be mentioned.

Examples of antibacterial components include chlorhexidine, salicylic acid, benzalkonium chloride, acrinol, etanol, benzethonium chloride, cresol, gluconic acid and derivatives thereof, popidone iodine, potassium iodide, iodine, and isopropylmethylpheno. -L, triclocarvan, triclosan, photosensitizer 101, photosensitizer 201, paraben, phenoxyetanol, alkyldiaminoglycine hydrochloride, cetylpyridinium chloride, pyroctoolamine, myconazole or a salt thereof, chlorobutanol, ethylhexyl glycerin, butyl Propinyl iodide carbamate, caprylhydroxamic acid, phenethylalkonium, methylisothiazolinone, sorbic acid, β-glycyrrhetinic acid, components derived from plants (eg, clara, rosemary, quat, eucalyptus, etc.) Etc.

Examples of the cooling agent include mentoles and their derivatives, camphor, borneol, geraniol, cineole, annetol, limonene, eugenol and other terpenes (these are d-form and l-form). Or dl form.); Essential oils such as eucalyptus oil, bergamot oil, peppermint oil, cool mint oil, sparemint oil, camphor oil, peppermint oil, kehi oil, rose oil, terpene oil, etc. Can be mentioned.

Examples of organic acids include gluconic acid, aspartic acid, aminoethylsulfonic acid, citric acid, glutamic acid, succinic acid, oxalic acid, fumaric acid, malonic acid, maleic acid, propionic acid, malic acid, salicylic acid, and glyco-lic acid. , Phytic acid, tartrate acid, acetic acid, lactic acid, pantothenic acid, glycyrrhetinic acid, alginic acid, ascorbic acid, benzoic acid, adipic acid, glutamic acid, azelaic acid and salts thereof.

Examples of the anti-glycation component include plant extracts such as Budreja axilaris leaf extract, plum fruit extract, and edelweiss extract, evening primrose oil, amla fruit, fruit juice or extracts thereof, L-arginine, and L-. Examples thereof include lysine, hydrolyzed casein, hydrolyzable tannin, carnosin and the like.

Examples of the cell activating component include amino acids such as γ-aminobutyric acid and ε-aminocaproic acid: vitamins such as retinol, thiamine, riboflavin, pyridoxine hydrochloride, and pyroquinolinquinones pantothenate; gluconic acid and phytic acid. , Α-Hydroxy acids such as glyco-acid, lactic acid; tannins, flavonoids, saponins, allantin, photosensitizer No. 301, components derived from plants (eg, soybean buds, bilbery leaves, etc.), and the like.

Convergent components include, for example, metal salts such as alum, chlorohydroxyaluminum, aluminum chloride, allantoin aluminum salt, zinc paraphenol sulfonate, basic aluminum lactate zinc lactate, zinc sulfate, potassium aluminum sulfate; tannic acid, citric acid, lactic acid. , Organic acids such as succinic acid can be mentioned.

Antioxidant components include, for example, butylhydroxyanisole, dibutylhydroxytoluene, sodium bisulfite, sodium pyrosulfite, erythorbic acid and its salts, ascorbic acid and its salts, flavonoids, glutathione, glutathione peroxydase, glutathione- Examples thereof include S-transferase, catalase, superoxide dismutase, thioredoxin, taurine, thiotaurine, hypotaurine, and plant extracts (watermelon flower extract, etc.).

Examples of anti-aging ingredients include hydrolyzed soy protein, retinoids (retinol, retinoic acid, retinal, etc.), pangamic acid, ursoic acid, turmeric extract, sphingosine derivatives, silicon, silicic acid, and N-methyl. -L-serine, mevalonolactone, peptides (caprooil tetrapeptide-3, oligopeptide-24, etc.) and the like can be mentioned.

Moisturizing ingredients include, for example, amino acids such as alanine, serine, aspartic acid, glycine, proline, hydroxyproline, glucosamine, theanine, arginine and derivatives thereof; glycerin, dipropylene glycol, 1,3-butanjiol and the like. Polyvalent alcohols; sugar alcohols such as sorbitol, xylitol, erythritor, maltose-sucrose condensate (glucooligosaccharide); glycosyl trehalos, trehalos; ceramides, glucosyl Ceramide, cholesterol, phytosterol, cholesterol derivative, phytosterol derivative ;; phospholipids such as lecithin, hydrogenated lecithin; NMF-derived components such as lactic acid, sodium lactate, sodium pyrrolidone carboxylate, urea; Gen, elastin, keratin, chitin, chitosan and their hydrolysates; hydroxyethylurea; components derived from plants (eg chamomile, hamamelis, cha, perilla, grapefruit, amachazuru, etc.), etc. Be done. Among them, glycine, arginine, glycerin, dipropylene glycol, 1,3-butanjiol, glycosyltrehalose, ceramide, glucosylceramide, cholesterol, cholesterol derivative, phytosterol derivative, hydrogenated lecithin. , Lactic acid, sodium lactate, sodium pyrrolidone carboxylate, urea ;; preferably one or a combination of two or more selected from collagen, elastin, keratin and hydroxyethylurea.

Examples of the polyvalent alcohol include dials having 2 to 4 or 11 or more carbon atoms, polyvalent alcohol having 3 or more hydroxy groups, and the like, for example, glycerin, diglycerin, triglycerin, and propylene glycol. Glycerol, dipropylene glycol, 1,3-butanediol, ethylene glycol, diethylene glycol, isopylene glycol, 1,3-butylene glycol, and the like.

Examples of the keratin softening component include lanolin, urea, phytic acid, lactic acid, lactate, glycolic acid, salicylic acid, malic acid, citric acid, fluoric acid, phytic acid, urea and sulfur.

Examples of vitamins include retinoyl derivatives such as retinal and retinoyl linoleate, retinal, retinoic acid, methyl retinoate, ethyl retinoate, retinoate retinoate, and d-δ-. Vitamin A such as tocopheryl retinoate, α-tocopheryl retinoate, β-tocopheryl retinoate; β-carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, Provitamin A such as cryptoxanthin and equinenone; vitamin E such as tocopherol linoleic acid, tocopherol (lino-acid / oleic acid), potassium (ascorbyl / tocopheryl) potassium phosphate; riboflavin, flavin mono Vitamin B2 such as nucleotides, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyric acid ester, riboflavin 5'-phosphate sodium, riboflavin tetranicotinic acid ester; the above-mentioned methyl nicotinate, nicotinic acid, benzyl nicotinate, etc. Nicotinic acids other than the component (A); ascorbyl stearate, disostearyl ascorbyl phosphate, L-ascorbyl dipalmitate, ascorbyl tetraisopalmitate (ascorbyl tetra2-hexyldecanoate), ascorbyl palmitate disodium, Ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbyl phosphate, magnesium ascorbyl phosphate, ascorbyl glucoside, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, glyceryl ascorbic acid, bis Vitamin Cs such as glyceryl ascorbyl, alkyl glyceryl ascorbyl, etc .; Vitamin Ds such as methyl hesperidin, ergocarciferol, chorecalciferol; Vitamin Ks such as phyllokinone, farnoquinone; thiamine and salts thereof Vitamin B1s (eg, dibenzoylthiamine hydrochloride, thiamine hydrochloride, thiaminniphosphate, etc.); vitamins such as pyridoxin hydrochloride, pyridoxin acetate, pyridoxal hydrochloride, 5'-pyridoxal phosphate, pyridoxamine hydrochloride Vitamin B12s such as B6, cyanocobalamine, hydroxocobalamine, deoxyadenosylcobalamine; folic acids such as folic acid and pteroylglutamic acid; pantothenic acid, calcium pantothenate, pantothenyl alcohol ( Pantothenic acids such as pantenol), D-pantethein, D-pantetin, coenzyme A, pantothenyl ethyl ether, calcium pantethene sulfonate; biotins such as biotin and biocithin; in addition, carnitine, ferulic acid, α Examples thereof include vitamin-like acting factors such as-lipoic acid, orotic acid, γ-oryzanol, pyrroloquinoline quinone, hesperidin and glucosyl herperidine, ubiquinone, and salts thereof.

Examples of blood circulation promoting components include plants (eg, Panax ginseng, Ashitaba, Arnica, Angelica acutiloba, Angelica acutiloba, Swertia japonica, Dutch oyster, Chamomile, Roma chamomile, Carrot, Gentiana, Gobo, Rice, Sanzashi, Shiitake, Swertia japonica, S. Senkyu, Swertia japonica, Thyme, Chouji, Chimpi, Angelica acutiloba, Tounin, Touhi, Carrot, Ginseng, Butcher bloom, Grape, Button, Maronnier, Melissa, Yuzu, Yokuinin, Rosemary, Rose hip, Chimpi, Touki , Angelica acutiloba, peach, apricot, walnut, corn); dl-α-tocopherol acetate, tocopherol nicotinate, glucosyl hesperidin, hesperidin.

Examples of the sebum-adsorbing component include talc, mica, hydroxyapatite, zinc oxide, aluminum silicate and the like. Of these, mica, hydroxyapatite, and zinc oxide are preferable, and mica is particularly preferable.

Examples of the peptide or its derivative include keratin-degrading peptides, hydrolyzed keratin, collagen, fish-derived collagen, atelocolagen, succinylated atelocolagen, gelatin, elastin, elastin-degrading peptide, and collagen-degrading peptide. , Hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin-degraded peptide, conchiolin-degraded peptide, hydrolyzed conchiolin, silk proteolytic peptide, hydrolyzed silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, water Degraded soybean protein, wheat protein, wheat proteolytic peptide, hydrolyzed wheat protein, casein-degrading peptide, acylated peptide (palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide, etc.) and the like can be mentioned.

Examples of amino acids or derivatives thereof include betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, and cystine. , Methionin, leucine, isoleucine, valine, histidine, threonine, tyrosine, taurine, γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid, carnitine, carnosin, creatin, epsilon aminocaproic acid, tryptophan, ornithine, N-stearoyl-L -Sodium glutamate, lysine dilauroyl glutamate and salts thereof, di lauroyl glutamate (phytosteryl / octyldodecyl), di lauroyl glutamate (octyldodecyl / phytosteryl / behenyl) and the like can be mentioned. Further, these amino acids or derivatives thereof may be solvates such as hydrates, and may be d-form, l-form, or dl-form. Among them, one kind or two or more kinds selected from l-form amino acids or derivatives thereof are preferable.

Further, in addition to the above-mentioned components, the external composition of the present invention may appropriately contain components usually used in fields such as pharmaceuticals, quasi-drugs, and cosmetics, depending on the intended use or dosage form. .. The components that can be blended are not particularly limited, but are, for example, bases or carriers, surfactants, thickeners, antioxidants, preservatives, preservatives, pH adjusters, killer agents, stabilizers, and irritants. Additives such as lighteners, colorants, dispersants, and fragrances can be added. In addition, these components can be blended alone or in any combination of two or more. Further, these contents can be appropriately determined from a conventionally known range within a range that does not impair the effects of the present invention. Further, those corresponding to the following plurality of components can be added as components having any function among them.

As the base or carrier, aqueous bases such as water; hydrocarbons such as vaseline, paraffin, microcrystallin wax, polybutene, polyethylene powder, gelled hydrocarbons (such as plastic base), ozokelite, etc .; highly polymerized methylpoly Phenyl-modified silicones such as siloxane, cyclic silicones, methylhydrogenpolysiloxanes, methyltrimethicone, dimethiconols, dimethiconol crosspolymers, alkyl-modified silicones such as caprylylmethicone, cross-linked alkyl-modified silicones. Phenyl, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, cross-linked polyether-modified silicone, cross-linked alkyl polyether-modified silicone, silicone-alkyl Chain co-modified polyester-modified silicone, silicone-alkyl chain co-modified polyglycerin-modified silicone, polyester-modified branched silicone, polyglycerin-modified branched silicone, acrylic silicon, phenyl-modified silicone Phenyl, silicate oils such as silicate resin; higher alcohols such as setanol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, phytosterol, cholesterol; lauric acid. , Higher fatty acids such as myristic acid, palmitic acid, stearic acid, and behenic acid; cellulosic derivatives such as ethyl cellulosic, hydroxypropyl cellulosic, hydroxypropylmethyl cellulosic; polyvinylpyrrolidone ;; polyvinylbutyra -To; polyethylene glycol; dioxane; butylene glycol adipate polyester; cetyl lactate, dextrin palmitate, inulin stearate, tri2-ethylhexyl trimeritate, tritridecyl trimeritate, tri (capric acid / capric acid / myristic acid) / Steeric acid) Glyceryl, dilauroyl glutamate (phytosteryl / octyldodecyl), dilauroyl glutamate (octyldodecyl / phytosteryl / behenyl), dimer-dilinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimer-dylino -Dimer acid acid-diesylinorail, dipentaerythrityl tripolyhydroxystearate, tri (bechenic acid / isostearic acid / eicosandiic acid) esters such as glyceryl; waxes such as miuro, candelilla wax, rice bran wax, cotton wax, carnauba wax, lanolin, etc. Fats and oils; Dextri Polysaccharides such as maltodextrin; vinyl polymers such as carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers; lower alcohols such as etanol and isopropanol ;; sorbitol, xylitol- Sugar polymers such as le, erythritol, and mannitol; water and the like can be mentioned. As the base or carrier selected from these components, one type may be used alone, or two or more types may be used in combination. The amount used thereof is appropriately selected from a range known to those skilled in the art.

When the external composition of the present invention contains water, the content thereof varies depending on the form of the external composition and is not particularly limited. For example, the amount of water is preferably 10 to 99% by mass, more preferably 50 to 95% by mass, and further preferably 60 to 90% by mass with respect to the total amount of the external composition of the present invention.

When the external composition of the present invention contains an oil other than the liquid oil (D) as a base, the content thereof varies depending on the form of the external composition and is not particularly limited. With respect to the total amount of the external composition of the present invention, for example, the amount of oil other than (D) liquid oil is preferably 0.0001 to 5% by mass, more preferably 0.001 to 1% by mass, still more preferable. Is 0.005 to 0.5% by mass.

Examples of the surfactant include sorbitan monoisostearate, sorbitan monostearate, tetra-2-ethylhexyl diglycerol sorbitan, sorbitan monooleate, sorbitan monoisostearate and sorbitan. Polysorbate fatty acid ester such as monolaurate; polyoxyethylene monolaurate (20) sorbitan, polyoxyethylene monolaurate (80) sorbitan, polyoxyethylene monostearate (20) sorbitan, polyoxyethylene monooleate (20) Polyoxyethylene sorbitan fatty acid esters such as sorbitan and polyoxyethylene isostearate (20) sorbitan; glycerin fatty acid esters such as glycerin monooleate, glycerin monostearate, and glycerin monomyristate; Glycerin alkyl ethers such as monoisostearyl glyceryl ether and monomyristyl glyceryl ether; diglyceryl monostearate, decaglyceryl decasterate, decaglyceryl decaisostearate, and diglyceryl dii Polyglycerin fatty acid esters such as polysorbate; propylene glycol fatty acid esters such as propylene glycol monostearate; polyoxyethylene hydrogenated castor oil 40, polyoxyethylene cured castor oil 50, polyoxyethylene cured castor oil 60, cured castor oil derivative such as polyoxyethylene cured castor oil 80; polyoxyethylene glycerin fatty acid ester such as polyoxyethylene monococonut oil fatty acid glyceryl; polyoxyethylene (20) phytosterol, polyoxyethylene (30) phytostero Polyoxyethylene sterol, hydrogenated sterol such as poly, polyoxyethylene (25) phytostanol, polyoxyethylene (30) cholestanol; sucrose fatty acid ester; polyoxyalkylene alkyl (or alkenyl) Ether sulfate, ether carboxylate, alkyl phosphate ester salt, N-acyl amino acid salt, acylated tauret; amines such as stearylamine and oleylamine; polyoxyethylene / methylpolysiloxane copolymer, Silicon-based surfactants such as lauryl PEG-9 polydimethylsiloxyethyl dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone or lecithin, hydrogenated lecithin, saponin, sorbatin sodium, cholesterol, Examples thereof include naturally occurring surfactants such as bile acids.

Examples of the thickener include vinyl thickeners such as polyacrylic acid amide, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methyl ether, and carboxyvinyl polymer, methyl cellulosic, ethyl cellulosic, and hydroxyethyl cellulos. Cellulosic thickeners such as phosphate, hydroxymethylcellose, hydroxypropylcellose, hydroxypropylmethylcellose, carboxymethylcellose, carboxyethylcellose, guar gum, sclerothium Gum, tamarind gum, xanthan gum, dextran, pectin, purulan, gelatin, locust bean gum, caragi-nan, agar, alkyl methacrylate copolymer, sodium polyacrylate, bentonite, dextrin fatty acid ester, dimethyl distearyl Ammonium hectrite, sodium alginate, propylene glycol alginate, polyethylene glycol, macrogol, (hydroxyethyl acrylate / acryloyldimethyltaurine Na) copolymer, (acryloyldimethyltaurinammonium / vinylpyrrolidone) copolymer, etc. Be done.

Examples of the antioxidant include dibutylhydroxytoluene, butylhydroxyanisole, sorbic acid, sodium sulfite, ascorbic acid, ascorbic acid derivative, tocopherol, tocopherol derivative, erythorbic acid, sodium erythorbate, and L-cysteine. Examples thereof include hydrochloride, ubiquinones such as coenzyme Q10, lignans such as sesamine, curcumin, capsaicin, gingerol, resveratrol, anthocyanin, cyanidin, bilbery extract and their relatives or derivatives.

Examples of preservatives or preservatives include benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, paraoxy. Benzyl benzoate, methyl paraoxybenzoate, phenoxyethaneol, benzyl alcohol, chlorobutanol, sorbic acid and its salts, chlorhexidine gluconate, methylisothiazolinone, propynyl iodide butylcarbamate, caprylhydroxamic acid, phenethylalco -L, ethylhexyl glycerin, glyceryl caprate, isopropylmethylphenol and the like can be mentioned.

Examples of the pH adjuster include inorganic acids (hydrochloride, sulfuric acid, etc.), organic acids (lactic acid, sodium lactate, citrate, sodium citrate, succinate, sodium succinate, etc.), and inorganic bases (potassium hydroxide, hydroxide). (Sodium, etc.), organic bases (triethanolamine, diisopropanolamine, triisopropanolamine, etc.) and the like can be mentioned.

Examples of the killer agent include ethylenediaminetetraacetic acid (edetic acid), ethylenediaminetetraacetic acid salt (sodium salt (sodium edetate: Japanese Pharmacopoeia, EDTA-2Na, etc.), potassium salt, etc.), phytic acid, gluconic acid, and the like. Examples thereof include polyphosphoric acid and metaphosphoric acid. Of these, sodium edetate is preferable.

Examples of the stabilizer include sodium polyacrylate, dibutylhydroxytoluene, butylhydroxyanisole and the like.

Examples of the irritation reducing agent include licorice extract, gum arabic, polyvinylpyrrolidone and the like.

[PH] The external composition of the present invention usually has physical characteristics of pH 4 to 9, but is preferably pH 4.5 to 4 from the viewpoint of low irritation to the skin and mucous membranes and good skin usability. It is 8.5, more preferably pH 5-8, and even more preferably pH 6-8.

[Method for producing an external composition] The method for producing an external composition of the present invention is not particularly limited, and in addition to the above components (A) to (D), the above other components and the like are usually selected and blended. According to the method, it can be produced by emulsifying if necessary.

[Usage] Specifically, when it is used as an external composition for non-medicinal products or cosmetics, for example, lotion, milky lotion, gel, cream, beauty liquid, sunscreen cosmetic, pack. Basic cosmetics such as masks, hand creams, body lotions; and cleaning cosmetics such as wash pigments, hand soaps, makeup removers, body-shamps, shamps, rinses, and treatments. , Foundations, makeup bases and other face makeup cosmetics, hair gels, hair masks, hair mists, hair lotions, hair cosmetics such as styling agents, and the like. Of these, external compositions for the skin are particularly preferable. That is, the external composition of the present invention can be an external composition for pharmaceuticals, quasi-drugs, or cosmetics. The formulation form of the external composition is the same as that of the external composition of the present invention. Further, the bases or carriers, additives, and active ingredients that can be used, and their preferred ones, are the same as in the case of the external composition of the present invention. Among them, a formulation selected from a lotion, a milky lotion, a gel, a beauty essence, a sunscreen cosmetic, a pack, a mask, a hand cream, a body lotion, a hair gel, a hair mist, and a hair lotion is more preferable. Further, application to a lotion, a milky lotion, a gel, a beauty essence, a sunscreen cosmetic, or a mask is more preferable because it particularly affects the appearance of the preparation due to the transparency of the preparation, which is one of the effects of the present invention.

[Container] The external composition of the present invention can be contained and used in a container having a shape and material appropriately selected according to the purpose of use and use. Specific examples of the container include a spray type, a bottle type, a tube type, a jar type, a dropper type, a dispenser type, a stick type, a pouch bag, and a cheer pack.

Examples of the material of the container include polyethylene terephthalate, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ABS resin, ethylene vinyl alcohol resin, polystyrene, glass, metal (aluminum, etc.) and the like. .. In addition, these materials are subjected to various coating treatments in consideration of strength, flexibility, weather resistance, stability of components, etc., and these materials are combined or laminated by, for example, mixing them. Then, it can be used as a container material. Examples of the coating material include epoxy resin and polyamide-imide. Of these, polypropylene, polyethylene (HDPE, LDPE, LLDPE, etc.), ethylene vinyl alcohol resin, and metal (aluminum, etc.) are preferably used.

[Usage, etc.] The external composition of the present invention is expected to have the physiological activity of a heparinoid, and is used for moisturizing, anti-inflammatory, frost, treatment and prevention of hypertrophic scars / keloids, progressive palmar keratopathy, cortex. It can be suitably used for the purpose of swelling, hematoma, tendon sheath inflammation, muscle pain, arthritis, etc. after deficiency and trauma (bruise, sprain, contusion). Furthermore, the effect of improving the barrier function can be expected, and it is useful as a multifunctional preparation. The external composition of the present invention can be used in a known or commonly used dosage and administration in 1 to several divided doses per day depending on the intended use.

Next, the present invention will be specifically described with reference to Examples, but the present invention is not limited to the following Examples. The unit of numerical values in each table is weight (%) unless otherwise specified.

[Examples 1 to 3 and Comparative Examples 1 to 6]
The compositions of the formulations shown in Table 1 below were prepared by a conventional method.
[Table 1]

[Test Example 1-1: Immediately after preparation (evaluation of transparency)] The transparency of the compositions of Example 1 and Comparative Examples 1 and 2 shown in Table 1 above was evaluated immediately after preparation under the following measurement conditions. .. The results are shown in Table 2 below. [Evaluation of Transparency] For the transparency of the preparation, 200 μL of each composition was dispensed into 96-well plates (SBS standard) and 630 nm with a micro-pretrider (SH-9000, manufactured by Corona Electric Co., Ltd.). (Measurement method: Absorbance measurement direction: ↑↑) was measured and evaluated according to the following evaluation criteria. As a control example, the absorbance of purified water was measured by the same method, and a result of "-0.004" was obtained. [Transparency evaluation criteria] [Judgment]: [630 nm absorbance] Transparent: Less than 0.01 Slightly translucent: 0.01 or more and less than 0.1 Translucent: 0.1 or more and less than 0.3 Opacity: 0.3 or more

[Test Example 1-2: Immediately after production (visual evaluation of transparency)] The transparency immediately after the compositions of Example 1 and Comparative Examples 1 and 2 shown in Table 1 above are prepared under the following measurement conditions. evaluated. The results are shown in Table 2 below. [Evaluation of Transparency in Appearance] For visual evaluation of the transparency of the preparation, each composition was filled in a 30 mL glass screw cap bottle so as to have a height of 3 cm, and then the characters of the font 14 were displayed under the glass bottle. The appearance and sharpness can be evaluated according to the following evaluation criteria. [Appearance Transparency Evaluation Criteria] [Judgment]: [Judgment Criteria] 5: Characters can be seen very clearly and the sharpness is very high. 4: Characters are clearly visible and sharpness is high. 3: Characters can be seen, but the sharpness is slightly inferior. 2: The characters are barely visible, but the clarity is poor. 1: The characters are unreadable and opaque. [Table 2]

From the results in Table 2, in Test 1-1, Example 1 showed the same absorbance as the purified water described as the reference example, and was colorless and transparent as well as the reference example in the visual evaluation of the appearance, and the characters were written. There was no difference in appearance. In Comparative Examples 1 and 2, another component belonging to the same mucopolysaccharide was blended in place of the component (A) of Example 1. In Comparative Example 1, the numerical value of the absorbance in Test 1-1 was also in the opaque category, and the presence of characters could not be recognized by the visual evaluation in Test 2-2. In Comparative Example 2, the numerical value of the absorbance in Test 1-1 was in the translucent category, but in the visual evaluation in Test 2-2, the characters were visible, but the sharpness was considerably inferior to that of Example 1. ..

[Test Example 1-3: Appearance and Appearance Stability (Transparency)] 50 g of each composition (Examples 1 to 3 and Comparative Examples 1 to 6) of the formulation shown in Table 1 above is filled in a 50 mL glass screw cap bottle. Then, a thermal stability test (3 days) and a light stability test (260,000 luX irradiation) at 60 ° C. were carried out. (Each test condition) Thermal stability test condition: Stored in a constant temperature chamber at 60 ° C for 3 days. Light irradiation test conditions: At 25 ° C., light from a D65 fluorescent lamp, which is a standard light source defined by the International Commission on Illumination (CIE), was irradiated at 3800 lX / h for about 69 hours (total 260,000 lX · hr). After the completion of each of the above stability tests, the transparency and the stability of the appearance (transparency) under each stability test condition were evaluated for the sample cooled at 25 ° C. under the following measurement conditions. In addition, a comprehensive judgment was made regarding the stability of the appearance from the results of the thermal stability test and the optical test. These results are shown in Table 3. In addition, the transparency of each composition of the formulations shown in Table 1 (Examples 2 to 3 and Comparative Examples 3 to 6) is also evaluated immediately after preparation according to the above-mentioned Test 1-2. The results are also shown in Table 3. [Evaluation of Transparency] For the transmittance of the preparation, each composition was separated into 96-well plates (SBS standard), and the absorption spectrum was measured by a microplater (SH-9000, manufactured by Corona Electric Co., Ltd.). (Measurement method: Absorbance measurement direction: →→) was measured and evaluated according to the following evaluation criteria. (Evaluation criteria for transparency immediately after production (absorption spectrum measurement)) [Judgment]: [630 nm absorbance] Transparency: -0.5 or more Slightly translucent: -2 or more and less than -0.5 Translucent: -5 or more -2 Less than opaque: less than -5

(Evaluation criteria for appearance stability (transparency) (absorption spectrum measurement)) Appearance stability (transparency) (difference in 630 nm absorbance) = value after stability test-initial value [difference in 630 nm absorbance]: [ Judgment] 5 or more: Appearance stability is reduced 1 or more and less than 5: Appearance stability is slightly reduced -1 or more and less than 1: Appearance stability is good -3 or more and less than -1: Appearance stability is Slightly reduced -6 or more and less than -3: Deteriorated appearance stability Less than -6: Significantly reduced appearance stability (comprehensive judgment of appearance stability (transparency))] [Appearance stability (transparency) : Judgment] ◎: Stable in both heat and photostability ○: Slightly reduced in either heat or photostability △: Decreased or slightly reduced in either heat or photostability X: Heat or photostability Either one drops significantly or both drop

(Appearance stability (maintenance of transparency)) Regarding the appearance stability of the present invention, the lower the value of the absorbance at 630 nm in the absorption spectrum measurement, the lower the transmittance, that is, the lower the transparency. Means. Therefore, the larger the difference between the values obtained by subtracting the initial value from the absorbance after the stability test, the lower the transparency (the turbidity deteriorates), and the less stable the appearance. Means. On the other hand, the larger the difference in absorbance described above, the higher the transmittance and the higher the transparency, which means that the appearance is changed, which means that the stability of the appearance is not good. Therefore, the closer the difference in absorbance before and after the test is to 0, the more stable the appearance (maintains transparency).

From the results in Table 3, in each of the examples (Comparative Examples 1, 3 and 5) in which gellan gum, which is one of the other polysaccharides, was blended in place of the component (A) of Examples 1 to 3, the absorbance after the test was high. Both thermal stability and light stability are on the increase, and the appearance stability (transparency) is not good. Further, in all the examples in which Kanten was blended (Comparative Examples 2, 4, and 6), the absorbance was lowered in both thermal stability and photostability, that is, the transparency was lowered, and the appearance stability (transparency) was greatly deteriorated. I found out that I would do it. It was found that the examples were stable in both the optical test and the thermal stability test, and the stability (transparency) of the appearance was maintained.

[Test Example 1-4: Stability (coloring)] Stability (coloring) was evaluated using the same test sample as in Test Example 1-3. [Evaluation of stability (coloring)] For coloring of the preparation, each composition was separated into 96-well plates (SBS standard) and used with a microabsorber (SH-9000, manufactured by Corona Electric Co., Ltd.). The absorption spectrum was measured (measurement method: absorbance measurement direction: →→), and the absorbance at 450 nm was used for evaluation according to the following evaluation criteria. (Coloring stability evaluation standard) Stability (coloring) (difference in 450 nm absorbance difference) = value after stability test-initial value [difference in 450 nm absorbance]: [judgment] 1 or more: stability (coloring) is slightly Decrease -1 or more and less than 1: Stability (coloring) is good -3 or more and less than -1: Stability (coloring) is slightly decreased -6 or more and less than -3: Stability (coloring) is decreased -6 or less : Stability (coloring) is considerably reduced (comprehensive judgment of appearance stability (transparency))) [Appearance stability (transparency): judgment] ◎: Stable in both heat and light stability ○: Heat and light Slightly reduced stability or slightly reduced thermal or photostability X: Significantly reduced or both thermal or photostability

(Stability (Coloring)) Regarding the stability (coloring) of the present invention, the lower the value of the absorbance at 450 nm in the absorption spectrum measurement, the more yellow the color of the preparation is. Therefore, the larger the value obtained by subtracting the initial value from the absorbance after the stability test is, the worse the yellowing is, and the poorer the stability (coloring) is. On the other hand, the larger the difference in absorbance described above, the lighter the color of the preparation and the more the appearance is changed, which means that the stability (coloring) is not good. Therefore, the closer the difference in absorbance before and after the test is to 0, the better the stability (coloring).

From the results in Table 3, in the example in which gellan gum, which is one of the other polysaccharides, was blended in place of the component (A) of Examples 1 to 3, the component (B) of Comparative Example 5 was mixed with 1,2 pentaneol. In the example in which the above was blended, the absorbance after the test was increased, which was not a good result in terms of appearance stability (transparency). Similarly, in the examples in which Kanten was blended (Comparative Examples 2, 4, and 6), it was found that the preparations were significantly yellowed in both thermal stability and photostability, and the stability (coloring) was significantly reduced. .. In each of the examples, it was found that the stability (coloring) was very good without yellowing in both the optical test and the thermal stability test.

[Test Example 1-5: Stability (pH)] The stability (pH) was evaluated using the same thermal stability test sample as in Test Example 1-3. (PH stability evaluation standard) Stability (pH) = Measured value after stability test-Initial value [Stability (pH)]: [Judgment] 1 or more: Stability (coloring) slightly decreased within ± 0.2 : ◎ ~ ± 0.3 or less: ○ ~ ± 0.4 or less: △ ± 0.5 [: X

[Table 3]

From the results in Table 3, an example in which gellan gum, which is one of the other polysaccharides, was blended in place of the component (A) in Examples 1 to 3, and an example in which canten was blended in the same manner (Comparative Examples 2, 4, and 6). Tends to lower the pH. In particular, the stability (pH) tends to decrease in the examples in which Kanten is blended (Comparative Examples 2 and 4). On the other hand, it was found that the pH of each of the examples did not change significantly and the stability (coloring) was good.

[Test Example 1-6: Feeling of use (stickiness, sliminess, penetration)] For each composition of the formulation shown in Table 1 above, a feeling of use (stickiness, sliminess) by 3 dedicated panelas according to the following evaluation criteria. The feeling of penetration) was evaluated. The feeling of use when an appropriate amount (about 0.05 g) of each test preparation was applied to the area of 2 cm x 2 cm inside the arm of 6 specialized panelists was scored in 3 stages according to the following items and criteria, and numerical values were given. Was averaged. The results are shown in Table 4. (Stickiness) 3: No stickiness. 2: Somewhat sticky. 1: It is sticky.
(Slimy)
3: There is no sliminess. 2: There is some sliminess. 1: There is sliminess.

[Table 4]

From the results in Table 4, compared with Comparative Example 1 in which gellan gum was added instead of the component (A) in Example 1 and Comparative Example 2 in which canten was added, Example 1 in which (A) a heparinoid was added was By blending with the component (B), the feeling of use in terms of stickiness and sliminess was good.

[Test Example 2-1]
The compositions of the formulations shown in Table 5 below were prepared by a conventional method.
The prepared composition was similarly evaluated for transparency, stability (appearance (transparency), coloring, pH) and usability immediately after production according to the test conditions of Test Examples 1-1 to 1-6 described above. .. The results are shown in Table 4.



[Table 5]

From the results in Table 5, good results were obtained in all the evaluation items for Example 4.

[Formulation Examples] Based on the formulations shown in Tables 6 to 31 below, the external composition for skin of the present invention (Formulation Examples 1-26) was prepared.

[Table 6] (Formulation Example 1 Toner 1)

[Table 7] (Formulation Example 2 Toner 2)

[Table 8] (Formulation Example 3 Toner 3)

[Table 9] (Formulation Example 4 Toner 4)

[Table 10] (Formulation Example 5 Impregnated Sheet Mask)

[Table 11] (Formulation Example 6 Mist Spray)

[Table 12] (Formulation Example 7 pH 6 O / W lotion)

[Table 13] (Formulation Example 8 pH 6.5 O / W lotion)

[Table 14] (Formulation Example 9 pH 6.3 O / W hand rotation)

[Table 15] (Formulation Example 10 pH 6.3 all-in-one gel)

[Table 16] (Formulation Example 11 pH 6.5 sunscreen gel lotion)

[Table 17] (Formulation Example 12 Essence)

In each of the preparation examples, it was a good composition that was not sticky and had an excellent usability.

Claims (10)

(A) Heparinoid;
(B) An external composition containing 1,3-propanediol, an arcandiol having 5 to 10 carbon atoms, and one or more selected from amphipathic components. The external composition according to claim 1, wherein the content of the component (A) is 0.01 to 5% by mass. The component (B) is 1,3-propanediol, arcandiol having 5 to 10 carbon atoms, decaglyceryl (eicosane diacid / tetradecanedioic acid), bisethoxydiglycol cyclohexanedicarboxylic acid, and succinic acid. One or 2 selected from the group consisting of diethylhexyl, diethoxyethyl succinate, polyoxyalkylene glyceryl ether, polyoxyalkylene diglyceryl ether, polyoxyalkylene alkyl ether, and polyoxyalkylene alkyl glucoside. The external composition according to claim 1 or 2, which is more than a species. The component (B) is 1,3-propanediol, 1,2-pentanediol, 1,2-hexanediol, cyclohexanedicarboxylic acid bisethoxydiglycol, polyoxybutylene polyoxyethylene polyoxy. Propylene glyceryl ether, polyoxyethylene polyoxypropylene glyceryl ether, polyoxyethylene polyoxypropylene decyltetradecyl ether, polyoxyethylene polyoxypropylene butyl ether, polyoxyethylene methyl glucoside and polyoxypropylene The external composition according to claim 3, which is one or more selected from the group consisting of methyl glucoside. The external composition according to any one of claims 1 to 4, further comprising one or more selected from the group consisting of the component (C) glycyrrhizate, a water-soluble ascorbic acid derivative, and tranexamic acid. The component (C) is dipotassium glycyrrhizinate, monoammonium glycyrrhizinate, sodium ascorbic acid phosphate, magnesium ascorbic acid phosphate, 2-O-ethylascorbic acid, 3-O-ethylascorbic acid, ascorbic acid glucoside, The external composition according to claim 5, which contains one or more selected from the group consisting of tranexamic acid. The external composition according to any one of claims 1 to 6, further containing the liquid oil component (D). The external composition according to any one of claims 1 to 7, wherein the external composition is liquid. The external composition according to any one of claims 1 to 8, wherein the external composition has a viscosity of 10 to 10000 mPa · s. The external composition according to any one of claims 1 to 9, wherein the external composition has a transparent to translucent appearance.