[go: up one dir, main page]

JP2017514877A5 - - Google Patents

Download PDF

Info

Publication number
JP2017514877A5
JP2017514877A5 JP2016567002A JP2016567002A JP2017514877A5 JP 2017514877 A5 JP2017514877 A5 JP 2017514877A5 JP 2016567002 A JP2016567002 A JP 2016567002A JP 2016567002 A JP2016567002 A JP 2016567002A JP 2017514877 A5 JP2017514877 A5 JP 2017514877A5
Authority
JP
Japan
Prior art keywords
methoxycyclopent
group
similarly
described below
same structure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016567002A
Other languages
English (en)
Other versions
JP2017514877A (ja
JP6505131B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/GB2015/051312 external-priority patent/WO2015170081A1/en
Publication of JP2017514877A publication Critical patent/JP2017514877A/ja
Publication of JP2017514877A5 publication Critical patent/JP2017514877A5/ja
Application granted granted Critical
Publication of JP6505131B2 publication Critical patent/JP6505131B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Description

同様に、１−メトキシシクロペンタ−３−イル基と３−メトキシシクロペンタ−１−イル基は、下記のとおり、同一の構造を有する。

JP2016567002A 2014-05-08 2015-05-05 イミダゾ［４，５−ｃ］キノリン−２−オン化合物および癌の処置におけるそれらの使用 Active JP6505131B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461990232P 2014-05-08 2014-05-08
US61/990,232 2014-05-08
PCT/GB2015/051312 WO2015170081A1 (en) 2014-05-08 2015-05-05 Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer

Publications (3)

Publication Number Publication Date
JP2017514877A JP2017514877A (ja) 2017-06-08
JP2017514877A5 true JP2017514877A5 (ja) 2018-06-14
JP6505131B2 JP6505131B2 (ja) 2019-04-24

Family

ID=53264681

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016567002A Active JP6505131B2 (ja) 2014-05-08 2015-05-05 イミダゾ［４，５−ｃ］キノリン−２−オン化合物および癌の処置におけるそれらの使用

Country Status (39)

Country Link
US (4) US9428503B2 (ja)
EP (1) EP3140303B1 (ja)
JP (1) JP6505131B2 (ja)
KR (1) KR102013021B1 (ja)
CN (1) CN106255692B (ja)
AP (1) AP2016009532A0 (ja)
AR (1) AR100340A1 (ja)
AU (1) AU2015257456B2 (ja)
CA (1) CA2946459C (ja)
CL (1) CL2016002735A1 (ja)
CR (1) CR20160523A (ja)
CY (1) CY1120248T1 (ja)
DK (1) DK3140303T3 (ja)
DO (1) DOP2016000281A (ja)
EA (1) EA031674B1 (ja)
ES (1) ES2670416T3 (ja)
HR (1) HRP20180697T1 (ja)
HU (1) HUE037558T2 (ja)
IL (1) IL248397B (ja)
LT (1) LT3140303T (ja)
MA (1) MA39960A (ja)
MX (1) MX374401B (ja)
NI (1) NI201600166A (ja)
NO (1) NO2714752T3 (ja)
NZ (1) NZ726042A (ja)
PE (1) PE20170403A1 (ja)
PH (1) PH12016502168A1 (ja)
PL (1) PL3140303T3 (ja)
PT (1) PT3140303T (ja)
RS (1) RS57223B1 (ja)
SG (1) SG11201609164VA (ja)
SI (1) SI3140303T1 (ja)
SM (1) SMT201800259T1 (ja)
SV (1) SV2016005312A (ja)
TN (1) TN2016000458A1 (ja)
TR (1) TR201807101T4 (ja)
TW (1) TWI662034B (ja)
UY (1) UY36112A (ja)
WO (1) WO2015170081A1 (ja)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107889488B (zh) * 2015-04-02 2020-08-11 默克专利股份公司 咪唑酮基喹啉和其作为atm激酶抑制剂的用途
GB201516504D0 (en) 2015-09-17 2015-11-04 Astrazeneca Ab Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
GB201519406D0 (en) * 2015-11-03 2015-12-16 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
GB201519568D0 (en) * 2015-11-05 2015-12-23 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
JP2019512512A (ja) * 2016-03-21 2019-05-16 アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａ Ａｋｔｉｅｂｏｌａｇ シンノリン−４−アミン化合物およびその癌治療への使用
MA44603A (fr) * 2016-04-07 2019-02-13 Astrazeneca Ab Oxyde de n,n-diméthyl-3-[[5-(3-méthyl-2-oxo-1-tétrahydropyran-4-yl-imidazo[4,5-c]quinolin-8-yl)-2-pyridyl]oxy]propan-1-amine utilisé comme modulateur de la protéine kinase atm (ataxia telangiectasia mutated) pour traiter le cancer
GB201608227D0 (en) * 2016-05-11 2016-06-22 Astrazeneca Ab Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
LT3558997T (lt) 2016-12-20 2021-04-26 Astrazeneca Ab Aminotriazolopiridino junginiai ir jų naudojimas vėžio gydymui
AU2018206111B2 (en) * 2017-01-09 2022-07-21 Impact Therapeutics (Shanghai), Inc Substituted fused heteroaryl compound serving as a kinase inhibitor, and applications thereof
CN106798741A (zh) * 2017-02-07 2017-06-06 宫英 一种治疗抑郁症的药物组合物
CN106692147A (zh) * 2017-02-07 2017-05-24 李明英 一种治疗男性不育的药物组合物
CN106822123A (zh) * 2017-02-09 2017-06-13 王艳苓 一种治疗心脑血管疾病的药物组合物
US11547703B2 (en) 2017-02-27 2023-01-10 Impact Therapeutics (Shanghai), Inc Substituted fused heteroaromatic tricyclic compounds as kinase inhibitors and the use thereof
JOP20190209A1 (ar) * 2017-03-16 2019-09-12 Astrazeneca Ab مركبات إيميدازو [ 4، 5-c ] كينولين-2-أون ديوترومية واستخدامها في علاج السرطان
CN111344293A (zh) 2017-09-20 2020-06-26 阿斯利康(瑞典)有限公司 1，3-二氢咪唑并[4，5-c]噌啉-2-酮化合物及其在治疗癌症中的用途
WO2019201283A1 (en) * 2018-04-20 2019-10-24 Xrad Therapeutics, Inc. Dual atm and dna-pk inhibitors for use in anti-tumor therapy
CN110386932A (zh) * 2018-04-20 2019-10-29 艾科思莱德制药公司 用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
KR102813324B1 (ko) * 2018-09-14 2025-05-26 수저우 잔롱 파마 리미티드 모세혈관확장성 운동실조증 돌연변이(ATM) 키나제의 선택적 조절제로서의 1-이소프로필-3-메틸-8-(피리딘-3-일)-1,3-디하이드로-2H-이미다조[4,5-c]신놀린-2-온 및 이의 용도
CA3116234A1 (en) * 2018-10-15 2020-04-23 Merck Patent Gmbh Combination therapy utilizing dna alkylating agents and atr inhibitors
WO2020178282A1 (en) * 2019-03-05 2020-09-10 Astrazeneca Ab Fused tricyclic compounds useful as anticancer agents
TW202102497A (zh) * 2019-03-29 2021-01-16 瑞典商阿斯特捷利康公司 化合物及它們在治療癌症中之用途
CN111909147B (zh) * 2019-05-10 2021-07-20 山东轩竹医药科技有限公司 Dna-pk抑制剂
US20220259211A1 (en) * 2019-07-10 2022-08-18 Impact Therapeutics (Shanghai), Inc Substituted pyrazoloquinazolinone compounds and application thereof
KR20220062003A (ko) * 2019-09-12 2022-05-13 임팩트 테라퓨틱스 (상하이), 인코포레이티드 치환된 이미다조퀴녹살린 화합물 및 이의 용도
CN115003672A (zh) * 2020-01-09 2022-09-02 南京明德新药研发有限公司 喹啉并咪唑类化合物及其应用
US20230087844A1 (en) * 2020-01-13 2023-03-23 Shanghai Huayu Biotechnology Co., Ltd. Use of n2-quincline or isoquinoline substituted purine derivatives in cancer treatment
EP4171651A1 (en) * 2020-06-24 2023-05-03 AstraZeneca UK Limited Combination of antibody-drug conjugate and atm inhibitor
EP3992191A1 (en) 2020-11-03 2022-05-04 Deutsches Krebsforschungszentrum Imidazo[4,5-c]quinoline compounds and their use as atm kinase inhibitors
WO2022193166A1 (en) * 2021-03-17 2022-09-22 Suzhou Zanrong Pharma Limited Selective modulators of ataxia telangiectasia mutated (atm) kinase and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0211649D0 (en) * 2002-05-21 2002-07-03 Novartis Ag Organic compounds
BRPI0416801A (pt) 2003-11-21 2007-01-09 Novartis Ag derivados de 1h-imidazoquinolina como inibidores de proteìna sinase
GB0510390D0 (en) * 2005-05-20 2005-06-29 Novartis Ag Organic compounds
PE20090717A1 (es) * 2007-05-18 2009-07-18 Smithkline Beecham Corp Derivados de quinolina como inhibidores de la pi3 quinasa
WO2010003025A1 (en) 2008-07-01 2010-01-07 Genentech, Inc. Bicyclic heterocycles as mek kinase inhibitors
WO2010038165A1 (en) 2008-09-30 2010-04-08 Pfizer Inc. Imidazo[1,5]naphthyridine compounds, their pharmaceutical use and compositions
TW201041888A (en) * 2009-05-06 2010-12-01 Plexxikon Inc Compounds and methods for kinase modulation, and indications therefor
PE20120224A1 (es) 2009-06-04 2012-04-04 Novartis Ag Derivados de 1h-imidazo-[4,5-c]-quinolinona
WO2010139747A1 (en) * 2009-06-04 2010-12-09 Novartis Ag 1H-IMIDAZO[4, 5-c]QUINOLINONE COMPOUNDS, USEFUL FOR THE TREATMENT OF PROLIFERATIVE DISEASES
PE20140918A1 (es) * 2009-09-28 2014-08-06 Hoffmann La Roche Compuestos de benzoxepina inhibidores de la pi3k
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CN102199152A (zh) 2010-03-25 2011-09-28 高大新 杂环咪唑类磷脂激酶抑制剂
CN102372711B (zh) * 2010-08-18 2014-09-17 山东轩竹医药科技有限公司 咪唑并喹啉类PI3K和mTOR双重抑制剂
JPWO2012026233A1 (ja) 2010-08-26 2013-10-28 日立建機株式会社 建設機械
DE102010035744A1 (de) 2010-08-28 2012-03-01 Merck Patent Gmbh Imidazolonylchinoline
CN102399218A (zh) * 2010-09-16 2012-04-04 和记黄埔医药（上海）有限公司 一类并合三杂环及其作为pi3k抑制剂的用途
KR20140014104A (ko) 2010-12-06 2014-02-05 피라말 엔터프라이지즈 리미티드 치환된 이미다조퀴놀린 유도체
AU2012240246A1 (en) 2011-04-04 2013-05-09 Netherlands Cancer Institute Methods and compositions for predicting resistance to anticancer treatment with protein kinase inhibitors
JP6042060B2 (ja) * 2011-09-26 2016-12-14 サノフイ ピラゾロキノリノン誘導体、その調製および治療上の使用

Similar Documents

Publication Publication Date Title
JP2017514877A5 (ja)
JP2017107167A5 (ja)
JP2017016753A5 (ja)
JP2014179090A5 (ja)
JP2017059339A5 (ja)
JP2016204575A5 (ja)
JP2015077594A5 (ja)
JP2017069240A5 (ja)
JP2017528346A5 (ja)
JP2016526891A5 (ja)
JP2017528401A5 (ja)
JP2017179103A5 (ja)
JP2017509780A5 (ja)
JP2016069397A5 (ja)
JP2017203885A5 (ja)
JP2016169268A5 (ja)
JP2017020017A5 (ja)
JP2018538325A5 (ja)
JP2016157119A5 (ja)
JP2017533170A5 (ja)
JP2017509782A5 (ja)
JP2017075254A5 (ja)
JP2015174850A5 (ja)
JP2016210942A5 (ja)
JP2016089045A5 (ja)