HUE037558T2 - Imidazo[4,5-c]kinolin-2-on vegyületek és alkalmazásuk rák kezelésében - Google Patents

Imidazo[4,5-c]kinolin-2-on vegyületek és alkalmazásuk rák kezelésében

Info

Publication number: HUE037558T2
Authority: HU; Hungary
Prior art keywords: quinolin; imidazo; cancer; compounds; treatment
Prior art date: 2014-05-08

Application number

HUE15724351A

Other languages

English (en)

Inventor

Bernard Christophe Barlaam

Kurt Gordon Pike

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-05-08

Filing date

2015-05-05

Publication date

2018-09-28

2015-05-05 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2018-09-28 Publication of HUE037558T2 publication Critical patent/HUE037558T2/hu

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

HUE15724351A 2014-05-08 2015-05-05 Imidazo[4,5-c]kinolin-2-on vegyületek és alkalmazásuk rák kezelésében HUE037558T2 (hu)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201461990232P	2014-05-08	2014-05-08

Publications (1)

Publication Number	Publication Date
HUE037558T2 true HUE037558T2 (hu)	2018-09-28

Family

ID=53264681

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HUE15724351A HUE037558T2 (hu)	2014-05-08	2015-05-05	Imidazo[4,5-c]kinolin-2-on vegyületek és alkalmazásuk rák kezelésében

Country Status (39)

Country	Link
US (4)	US9428503B2 (hu)
EP (1)	EP3140303B1 (hu)
JP (1)	JP6505131B2 (hu)
KR (1)	KR102013021B1 (hu)
CN (1)	CN106255692B (hu)
AP (1)	AP2016009532A0 (hu)
AR (1)	AR100340A1 (hu)
AU (1)	AU2015257456B2 (hu)
CA (1)	CA2946459C (hu)
CL (1)	CL2016002735A1 (hu)
CR (1)	CR20160523A (hu)
CY (1)	CY1120248T1 (hu)
DK (1)	DK3140303T3 (hu)
DO (1)	DOP2016000281A (hu)
EA (1)	EA031674B1 (hu)
ES (1)	ES2670416T3 (hu)
HR (1)	HRP20180697T1 (hu)
HU (1)	HUE037558T2 (hu)
IL (1)	IL248397B (hu)
LT (1)	LT3140303T (hu)
MA (1)	MA39960A (hu)
MX (1)	MX374401B (hu)
NI (1)	NI201600166A (hu)
NO (1)	NO2714752T3 (hu)
NZ (1)	NZ726042A (hu)
PE (1)	PE20170403A1 (hu)
PH (1)	PH12016502168A1 (hu)
PL (1)	PL3140303T3 (hu)
PT (1)	PT3140303T (hu)
RS (1)	RS57223B1 (hu)
SG (1)	SG11201609164VA (hu)
SI (1)	SI3140303T1 (hu)
SM (1)	SMT201800259T1 (hu)
SV (1)	SV2016005312A (hu)
TN (1)	TN2016000458A1 (hu)
TR (1)	TR201807101T4 (hu)
TW (1)	TWI662034B (hu)
UY (1)	UY36112A (hu)
WO (1)	WO2015170081A1 (hu)

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JP2019512512A (ja) *	2016-03-21	2019-05-16	アストラゼネカ・アクチエボラーグＡｓｔｒａｚｅｎｅｃａＡｋｔｉｅｂｏｌａｇ	シンノリン−４−アミン化合物およびその癌治療への使用
MA44603A (fr) *	2016-04-07	2019-02-13	Astrazeneca Ab	Oxyde de n,n-diméthyl-3-[[5-(3-méthyl-2-oxo-1-tétrahydropyran-4-yl-imidazo[4,5-c]quinolin-8-yl)-2-pyridyl]oxy]propan-1-amine utilisé comme modulateur de la protéine kinase atm (ataxia telangiectasia mutated) pour traiter le cancer
GB201608227D0 (en) *	2016-05-11	2016-06-22	Astrazeneca Ab	Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
LT3558997T (lt)	2016-12-20	2021-04-26	Astrazeneca Ab	Aminotriazolopiridino junginiai ir jų naudojimas vėžio gydymui
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CN106798741A (zh) *	2017-02-07	2017-06-06	宫英	一种治疗抑郁症的药物组合物
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CN106822123A (zh) *	2017-02-09	2017-06-13	王艳苓	一种治疗心脑血管疾病的药物组合物
US11547703B2 (en)	2017-02-27	2023-01-10	Impact Therapeutics (Shanghai), Inc	Substituted fused heteroaromatic tricyclic compounds as kinase inhibitors and the use thereof
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CN110386932A (zh) *	2018-04-20	2019-10-29	艾科思莱德制药公司	用于抗肿瘤疗法中的双重atm和dna-pk抑制剂
KR102813324B1 (ko) *	2018-09-14	2025-05-26	수저우 잔롱 파마 리미티드	모세혈관확장성 운동실조증 돌연변이(ATM) 키나제의 선택적 조절제로서의 1-이소프로필-3-메틸-8-(피리딘-3-일)-1,3-디하이드로-2H-이미다조[4,5-c]신놀린-2-온 및 이의 용도
CA3116234A1 (en) *	2018-10-15	2020-04-23	Merck Patent Gmbh	Combination therapy utilizing dna alkylating agents and atr inhibitors
WO2020178282A1 (en) *	2019-03-05	2020-09-10	Astrazeneca Ab	Fused tricyclic compounds useful as anticancer agents
TW202102497A (zh) *	2019-03-29	2021-01-16	瑞典商阿斯特捷利康公司	化合物及它們在治療癌症中之用途
CN111909147B (zh) *	2019-05-10	2021-07-20	山东轩竹医药科技有限公司	Dna-pk抑制剂
US20220259211A1 (en) *	2019-07-10	2022-08-18	Impact Therapeutics (Shanghai), Inc	Substituted pyrazoloquinazolinone compounds and application thereof
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2012
- 2012-05-25 NO NO12793015A patent/NO2714752T3/no unknown
2015
- 2015-05-05 MX MX2016014639A patent/MX374401B/es active IP Right Grant
- 2015-05-05 PE PE2016002124A patent/PE20170403A1/es unknown
- 2015-05-05 SM SM20180259T patent/SMT201800259T1/it unknown
- 2015-05-05 EA EA201692095A patent/EA031674B1/ru not_active IP Right Cessation
- 2015-05-05 US US14/704,031 patent/US9428503B2/en active Active
- 2015-05-05 CA CA2946459A patent/CA2946459C/en active Active
- 2015-05-05 WO PCT/GB2015/051312 patent/WO2015170081A1/en not_active Application Discontinuation
- 2015-05-05 RS RS20180593A patent/RS57223B1/sr unknown
- 2015-05-05 PT PT157243510T patent/PT3140303T/pt unknown
- 2015-05-05 SI SI201530247T patent/SI3140303T1/en unknown
- 2015-05-05 ES ES15724351.0T patent/ES2670416T3/es active Active
- 2015-05-05 SG SG11201609164VA patent/SG11201609164VA/en unknown
- 2015-05-05 CN CN201580022454.1A patent/CN106255692B/zh active Active
- 2015-05-05 KR KR1020167034005A patent/KR102013021B1/ko active Active
- 2015-05-05 PL PL15724351T patent/PL3140303T3/pl unknown
- 2015-05-05 NZ NZ726042A patent/NZ726042A/en not_active IP Right Cessation
- 2015-05-05 AU AU2015257456A patent/AU2015257456B2/en active Active
- 2015-05-05 HR HRP20180697TT patent/HRP20180697T1/hr unknown
- 2015-05-05 HU HUE15724351A patent/HUE037558T2/hu unknown
- 2015-05-05 LT LTEP15724351.0T patent/LT3140303T/lt unknown
- 2015-05-05 AP AP2016009532A patent/AP2016009532A0/en unknown
- 2015-05-05 MA MA039960A patent/MA39960A/fr unknown
- 2015-05-05 TR TR2018/07101T patent/TR201807101T4/tr unknown
- 2015-05-05 TN TN2016000458A patent/TN2016000458A1/en unknown
- 2015-05-05 JP JP2016567002A patent/JP6505131B2/ja active Active
- 2015-05-05 CR CR20160523A patent/CR20160523A/es unknown
- 2015-05-05 DK DK15724351.0T patent/DK3140303T3/en active
- 2015-05-05 EP EP15724351.0A patent/EP3140303B1/en active Active
- 2015-05-06 UY UY0001036112A patent/UY36112A/es not_active Application Discontinuation
- 2015-05-07 AR ARP150101395A patent/AR100340A1/es not_active Application Discontinuation
- 2015-05-08 TW TW104114814A patent/TWI662034B/zh active
2016
- 2016-07-22 US US15/217,079 patent/US9822111B2/en active Active
- 2016-10-19 DO DO2016000281A patent/DOP2016000281A/es unknown
- 2016-10-19 IL IL248397A patent/IL248397B/en active IP Right Grant
- 2016-10-27 CL CL2016002735A patent/CL2016002735A1/es unknown
- 2016-11-02 PH PH12016502168A patent/PH12016502168A1/en unknown
- 2016-11-04 NI NI201600166A patent/NI201600166A/es unknown
- 2016-11-08 SV SV2016005312A patent/SV2016005312A/es unknown
2017
- 2017-10-17 US US15/785,974 patent/US10189834B2/en active Active
2018
- 2018-05-22 CY CY20181100532T patent/CY1120248T1/el unknown
- 2018-12-12 US US16/217,190 patent/US20190185468A1/en not_active Abandoned

Also Published As

Publication number	Publication date
MA39960A (fr)	2018-03-28
US20150336952A1 (en)	2015-11-26
US9428503B2 (en)	2016-08-30
CN106255692A (zh)	2016-12-21
PL3140303T3 (pl)	2018-08-31
AU2015257456B2 (en)	2018-02-15
EP3140303A1 (en)	2017-03-15
TW201625609A (zh)	2016-07-16
CA2946459A1 (en)	2015-11-12
TN2016000458A1 (en)	2018-04-04
SG11201609164VA (en)	2016-12-29
AR100340A1 (es)	2016-09-28
SV2016005312A (es)	2017-03-16
UY36112A (es)	2015-10-30
AP2016009532A0 (en)	2016-11-30
CY1120248T1 (el)	2019-07-10
TWI662034B (zh)	2019-06-11
JP2017514877A (ja)	2017-06-08
PT3140303T (pt)	2018-05-25
PE20170403A1 (es)	2017-05-07
NZ726042A (en)	2018-08-31
US20180134699A1 (en)	2018-05-17
TR201807101T4 (tr)	2018-06-21
NI201600166A (es)	2017-03-13
KR20160147054A (ko)	2016-12-21
EA031674B1 (ru)	2019-02-28
ES2670416T3 (es)	2018-05-30
US20160368920A1 (en)	2016-12-22
HRP20180697T1 (hr)	2018-06-01
EP3140303B1 (en)	2018-03-28
CN106255692B (zh)	2019-02-26
US20190185468A1 (en)	2019-06-20
PH12016502168B1 (en)	2016-12-19
JP6505131B2 (ja)	2019-04-24
IL248397B (en)	2019-02-28
CA2946459C (en)	2022-07-12
SMT201800259T1 (it)	2018-07-17
SI3140303T1 (en)	2018-06-29
WO2015170081A1 (en)	2015-11-12
US9822111B2 (en)	2017-11-21
KR102013021B1 (ko)	2019-08-21
CR20160523A (es)	2017-04-27
RS57223B1 (sr)	2018-07-31
DK3140303T3 (en)	2018-06-06
AU2015257456A1 (en)	2016-11-24
US10189834B2 (en)	2019-01-29
DOP2016000281A (es)	2016-12-15
EA201692095A1 (ru)	2017-08-31
LT3140303T (lt)	2018-05-25
NO2714752T3 (hu)	2018-04-21
PH12016502168A1 (en)	2016-12-19
CL2016002735A1 (es)	2017-02-10
MX2016014639A (es)	2017-03-06
BR112016025153A2 (pt)	2017-08-15
BR112016025153A8 (pt)	2021-07-20
MX374401B (es)	2025-03-06

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HUE054548T2 (hu)	2021-09-28	Amino-triazolopiridin vegyületek és azok alkalmazása rák kezelésében
IL258818A (en)	2018-06-28	Imidazo[4,5-c]quinolin-2-ion compounds and their use in cancer treatment
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GB201516504D0 (en)	2015-11-04	Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
IL276733A (en)	2020-09-30	Use of Aribolin in cancer treatment
IL266198A (en)	2019-06-30	Liposomal formulation for use in cancer treatment
GB201608227D0 (en)	2016-06-22	Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
ZA201804950B (en)	2020-11-25	Indolinones compounds and their use in the treatment of fibrotic diseases
IL266128B (en)	2021-06-30	History of naphthyridinone and its use in the treatment of arrhythmia
HUE045025T2 (hu)	2019-12-30	Heterobiciklusos vegyületek és alkalmazásuk tuberkulózis kezelésére
GB201604182D0 (en)	2016-04-27	Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
HRP20180788T1 (hr)	2018-06-29	[1,2,4]triazolo[4,3-b]piridazini za uporabu za liječenje proliferativnih bolesti
IL274868A (en)	2020-07-30	History of imidazopyridine and their use as medicine
HUE065202T2 (hu)	2024-05-28	Készítmény bélelváltozások kezelésében való felhasználásra
HK1255487A1 (en)	2019-08-16	Imidazo[4,5-c]quinolin-2-one compounds and their use in treating cancer
ZA201704727B (en)	2021-05-26	New imidazo[1,2-a]quinoxalines and derivates thereof for the treatment of cancer
HK1263136A1 (en)	2020-01-24	Indolinones compounds and their use in the treatment of fibrotic diseases