JP2017007997A - Liquid composition for oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for liquid oral cavity containing ascorbic acid ester or a salt thereof which gives excellent effective feeling (tightening feeling of gums).SOLUTION: The composition for liquid oral cavity contains: (A) 0.1 to 1 mass% of ascorbic acid phosphoric acid ester and/or a salt thereof; (B) 5 to 4, 530 ppm of fluorine ion; and (C) 0.01 to 1 mass% of orthophosphoric acid and/or a salt thereof. Further, the liquid composition for oral cavity contains (D) 0.1 to 20% mass% of a polyhydric alcohol and/or a sugar alcohol.SELECTED DRAWING: None

Description

  The present invention relates to a liquid oral composition containing an ascorbic acid ester or a salt thereof that gives an excellent feeling of effectiveness (a feeling of tightening gums).

  Ascorbic acid plays an important role in the expression of enzyme activity in the living body and is known to have various physiological activities. In particular, it acts as a coenzyme for prolyl and lysyl hydroxylase, and is essential for collagen synthesis. For this reason, it is useful for the prevention and treatment of gingivitis and periodontitis associated with collagen destruction, and various ascorbic acid derivatives have been developed in the past. In particular, ascorbic acid esters such as ascorbic acid phosphates or their salts have attracted attention. Has been. Many techniques using ascorbic acid esters or salts thereof in oral compositions have been proposed, and are disclosed in, for example, Patent Documents 1-7.

  On the other hand, in the oral composition, it is significant in terms of continuous use and improvement in the effect that the user feels the effect immediately after use, and the oral composition containing ascorbic acid ester or a salt thereof is significant. The same applies to objects.

JP 2012-180330 A JP 2004-26658 A JP-A-4-217618 JP-A-4-275213 JP 2014-5212 A JP 2013-256466 A JP 2012-131755 A

  As an effective feeling of prevention and treatment of gingivitis and periodontitis, it is preferable to give an appropriate feeling of tightening gums after use. However, with oral compositions containing ascorbic acid esters or salts thereof, it is difficult to realize the effect, and the actual effect has not been considered so far.

  This invention is made | formed in view of the said situation, and it aims at providing the composition for oral cavity containing ascorbic acid ester or its salt which gives the outstanding effective feeling (feeling of tightening gums).

  As a result of intensive studies to achieve the above object, the present inventor, as a liquid oral composition containing a specific amount of (A) ascorbic acid phosphate and / or a salt thereof as an ascorbic acid ester or a salt thereof, (B) Fluorine ions, particularly fluorine-containing compounds as their supply source, and (C) orthophosphoric acid and / or a salt thereof are combined in specific amounts to provide an excellent sense of effectiveness (feeling of tightening gums). The inventors have found that a satisfactory effect can be imparted, and have made the present invention.

That is, in the examination of the tightening feeling after use in the oral composition containing ascorbic acid phosphate ester and / or salt thereof, ascorbic acid phosphate ester and / or salt thereof does not have a feeling of tightening gums, Fluorine-containing compounds, orthophosphoric acid and / or salts thereof do not have a feeling of tightening gums, that is, each of these three components alone does not give a feeling of tightening gums. ), (B), and (C), when combined, within a specific range, these three components interact to produce a feeling of tightening the gums, making it difficult to realize the effect of mouthwash, etc. Even if it is a composition for liquid oral cavity, the feeling of tightening excellent gums can be imparted and the effect can be fully realized even immediately after use.
Furthermore, when (D) polyhydric alcohol and / or sugar alcohol is added, the astringency, bitterness and off-taste caused by the components (B) and (C) are improved, and the feeling of use (no astringency, bitterness or off-taste) is achieved. An excellent liquid oral composition can be obtained.

  Note that fluorine-containing compounds such as sodium fluoride and sodium monofluorophosphate are conventionally known as components that exert a caries prevention effect by acting on the tooth surface. In the present invention, such fluorine-containing compounds are known. (B) Fluorine ions supplied from the compound unexpectedly act on gums due to coexistence with (A) ascorbic acid phosphate and / or salt thereof, (C) orthophosphoric acid and / or salt thereof, and gum The liquid oral composition provides a particularly remarkable action and effect.

  Patent Documents 1 and 2 describe a dentifrice containing an ascorbic acid phosphate ester salt, a fluorine-containing compound and a disodium hydrogen phosphate, and Patent Documents 3 and 4 describe fluorine ions and calcium. It is disclosed that an ascorbic acid derivative or an alkali metal salt of phosphoric acid can be used as a substance effective for promoting colloidalization by ions. In these Patent Documents 1 to 4, a liquid oral composition containing an ascorbic acid ester or a salt thereof is disclosed. The effective feeling of the object (feeling of tightening the gums) has not been studied, nor is it mentioned, nor is it mentioned in Patent Documents 5-7. From Patent Documents 1 to 7, it is not possible to predict the provision of a specific effect (gum tightness) specific to the combination of the components (A), (B), and (C) according to the present invention.

Accordingly, the present invention provides the following liquid oral composition.
[1]
(A) 0.1-1% by mass of ascorbic acid phosphate and / or salt thereof,
(B) Fluorine ion 5-4,530 ppm,
(C) Orthophosphoric acid and / or salt thereof 0.01 to 1% by mass
A composition for liquid oral cavity, comprising
[2]
(B) The liquid oral composition according to [1], wherein the fluorine ion source is one or more fluorine-containing compounds selected from sodium fluoride, sodium monofluorophosphate and tin fluoride.
[3]
Component (C) is a hydrogen salt of one or more orthophosphoric acids selected from monosodium dihydrogen phosphate, disodium monohydrogen phosphate, monopotassium dihydrogen phosphate and dipotassium monohydrogen phosphate. [1] or [2] liquid oral composition.
[4]
(A) component content a, (B) component content b and (C) component content c (a + b) / c (where b is (B) fluorine ion The liquid oral composition according to [1], [2] or [3], wherein the mass ratio is 0.35 to 40 in terms of a sodium fluoride equivalent amount converted from the content.
[5]
Furthermore, (D) The composition for liquid oral cavity in any one of [1]-[4] formed by containing 0.1-20 mass% of polyhydric alcohol and / or sugar alcohol.
[6]
Liquid oral cavity composition in any one of [1]-[5] whose pH in 25 degreeC is 6.5-8.
[7]
The liquid oral composition according to any one of [1] to [6], which does not contain an abrasive.
[8]
The liquid oral cavity composition according to any one of [1] to [7], which is a mouthwash.

  ADVANTAGE OF THE INVENTION According to this invention, the liquid oral cavity composition containing the ascorbic acid phosphate ester and / or its salt which has the outstanding effective feeling (feeling of tightening gums) can be provided. Furthermore, the liquid oral composition can be provided that has no astringency, bitterness, or off-flavor and is easy to use. Since the liquid oral composition of the present invention has a satisfactory effect immediately after use, it can be expected that the user will continue to use the product and thereby improve the prevention / treatment effect of periodontal diseases.

  The composition for liquid oral cavity of the present invention contains (A) ascorbic acid phosphate and / or salt thereof, (B) fluorine ion, (C) orthophosphoric acid and / or salt thereof. In the present invention, these components (A), (B), and (C) are combined to give an effective feeling (a feeling of tightening the gums). I can't.

As (A) component ascorbic acid phosphate, ascorbic acid, one, or two or more of hydroxyl groups at 2nd, 3rd, 5th and 6th positions are converted to phosphates, for example, L -Ascorbic acid-2-phosphate ester, L-ascorbic acid-3-phosphate ester, L-ascorbic acid-6-phosphate ester, etc. are mentioned. In addition, examples of the salts include sodium salts, potassium salts, calcium salts, and magnesium salts. These ascorbic acid phosphates and salts thereof can be used alone or in combination of two or more. Among them, from the viewpoint of imparting an effective feeling and further the stability of the composition, a derivative in which the hydroxyl group at the 2-position or 3-position of ascorbic acid is converted to a phosphate ester is preferable, and more preferable is an ascorbic acid-2-phosphate ester. Magnesium salt and sodium salt.
Specifically, commercially available products such as L-ascorbyl magnesium phosphate and L-ascorbyl sodium phosphate manufactured by Wako Pure Chemical Industries, Ltd. and DSM Nutrition Japan Co., Ltd. can be used.

  The blending amount of the component (A) ascorbic acid phosphate and / or salt thereof is 0.1 to 1% (mass%, the same applies hereinafter) of the whole composition, preferably 0.2 to 0.8. %. If the blending amount is less than 0.1%, an effective feeling (feeling of tightening gums) cannot be imparted. If it exceeds 1%, the effect of providing an effective feeling (a feeling of tightening the gums) decreases, and a satisfactory effective feeling cannot be provided.

  (B) The fluorine ion of a component can be mix | blended as a fluorine-containing compound which supplies a fluorine ion. Examples of the fluorine-containing compound include sodium fluoride, sodium monofluorophosphate, tin fluoride, and the like. One of these can be used alone or two or more of them can be used in combination. In particular, sodium fluoride and sodium monofluorophosphate are preferable, and sodium fluoride is more preferable from the viewpoint of imparting an effective feeling (a feeling of tightening gums).

(B) Content in the composition of the fluorine ion of a component is 5-4,530 ppm, Preferably it is 40-2,300 ppm. When the content is within the above range, the feeling of tightening gums is excellent.
A fluorine-containing compound is mix | blended within the range of the said fluorine ion content, The compounding quantity can be calculated | required in conversion from fluorine ion content. For example, in the case of sodium fluoride, the blending amount is 0.001 to 1%, preferably 0.01 to 0.5% of the whole composition when calculated in terms of conversion. In the case of sodium monofluorophosphate, the blending amount is preferably 0.003 to 3.4%, particularly preferably 0.003 to 1.7% of the entire composition.

(C) As orthophosphoric acid and / or its salt, orthophosphoric acid, its alkali metal salt, ammonium salt, hydrogen salt, etc. can be used.
Orthophosphates include orthophosphates such as sodium phosphate, potassium phosphate, and ammonium phosphate, monosodium dihydrogen phosphate, disodium monohydrogen phosphate, monopotassium dihydrogen phosphate, dipotassium monohydrogen phosphate, etc. These can be used, and one of these can be used alone or two or more of them can be used in combination. Among these, from the viewpoint of imparting an effective feeling (a feeling of tightening of the gums), a hydrogen salt of orthophosphoric acid is preferable, and more preferably, it is monosodium dihydrogen phosphate and / or disodium monohydrogen phosphate.
In addition, even if a chelating agent having a phosphate group such as pyrophosphate or polyphosphate is used instead of orthophosphoric acid and / or a salt thereof, an effective feeling (a feeling of tightening gums) cannot be imparted. The goal is not achieved.

  The blending amount of orthophosphoric acid and / or a salt thereof as component (C) is 0.01 to 1%, preferably 0.03 to 0.5% of the entire composition. If the blending amount is less than 0.01%, it is impossible to give an effective feeling (feeling of tightening gums). If it exceeds 1%, the effect of providing an effective feeling (a feeling of tightening the gums) decreases, and a satisfactory effective feeling cannot be provided.

  Furthermore, in the present invention, (a + b) / c indicating the ratio of the sum of the content (a) of the component (A) and the content (b) of the component (B) and the content c of the component (C) is a mass ratio. It is preferable that it is 0.35-40, More preferably, it is 0.5-40. Within the above range, the effect of giving an effective feeling (feeling of tightening gums) is more excellent. Here, the b is equivalent to sodium fluoride converted from the content of (B) fluorine ions, and converted from the content (ppm) of fluorine ions (ppm) as the amount of sodium fluoride compound (%). Can be obtained (the same applies hereinafter).

When the composition of the present invention further contains (D) a polyhydric alcohol and / or a sugar alcohol, the feeling of use (astringency, bitterness, tastelessness) can be further improved.
(D) Examples of the polyhydric alcohol and sugar alcohol include glycerin, propylene glycol, sorbitol, xylitol, maltitol, lactitol, ethylene glycol, polyethylene glycol and the like, and one or more selected from these may be used. However, glycerin, propylene glycol, and sorbitol are preferred, and glycerin is particularly suitable for improving the feeling of use (astringency, bitterness, and taste).

  (D) When mix | blending the polyhydric alcohol and / or sugar alcohol of a component, 0.1-20% of the whole composition is preferable, 0.1-10% is more preferable, Especially preferably, it is 0.1. 2-8%. When the blending amount is within the above range, the feeling of use (astringency, bitterness, tastelessness) is further improved.

The liquid oral composition of the present invention preferably has a pH at 25 ° C. of 6.5 to 8, more preferably 7.0 to 7.9. In the present invention, when the pH is within the above range, it is possible to impart an effective feeling (feeling of tightening gums) while maintaining a better feeling of use (astringency, bitterness, tastelessness). If the pH is too high, a feeling of irritation may be manifested and the feeling of use may be reduced, or a feeling of tightening gums may not be imparted sufficiently and appropriately.
In addition, in order to adjust to the said pH, you may adjust by adding a pH adjuster suitably as needed. The pH adjuster is not particularly limited as long as it is a pH adjuster that can be used for oral preparations, such as phthalic acid, acetic acid, fumaric acid, citric acid, tartaric acid, malic acid, carbonic acid, bicarbonate, and potassium salts thereof, Examples include sodium salts, ammonium salts, ribonucleic acid and salts thereof, sodium hydroxide, hydrochloric acid and the like.

The liquid oral cavity composition of the present invention can be suitably prepared and applied as a dosage form such as a mouthwash, a mouth freshener, a concentrated mouthwash, and particularly as a mouthwash. A mouthwash containing the composition in the mouth and rinsing as it is is more preferable from the standpoint of effect. In this case, in addition to the above components, other known components can be blended as necessary according to the dosage form. For example, a liquid medium (solvent), a thickener, a surfactant, and, if necessary, preservatives, sweeteners, coloring agents, fragrances, active ingredients, and the like can be blended within a range that does not hinder the effects of the present invention.
The liquid oral composition of the present invention is a preparation in which the compounding components are dissolved, solubilized or emulsified in a liquid medium, and the compounding amount of insoluble solid components such as abrasives and pearlizing agents is 1% or less. It is preferable that it is not blended.

  For the liquid medium, purified water is usually used. In addition to purified water, a lower monohydric alcohol having 2 to 4 carbon atoms such as ethanol can be added, but it is preferably 20% or less (0 to 20%), preferably 15% or less, based on the entire composition. (0 to 15%) is more preferable, and 5% or less (0 to 5%) is particularly preferable. Alcohol-free preparations that substantially do not contain the lower alcohol (content of 100 ppm or less) are extremely preferable because they do not stimulate alcohol.

  Examples of the thickener include xanthan gum, carrageenan, sodium carboxymethyl cellulose, hydroxyethyl cellulose, sodium alginate, polyvinyl alcohol and the like. The blending amount of the thickener is usually 0 to 1%, particularly 0.1 to 1%.

As the surfactant, a known anionic surfactant, amphoteric surfactant, or nonionic surfactant can be used. Specifically, alkyl sulfate salts such as sodium lauryl sulfate, acylamino acid salts such as sodium lauroyl sarcosine, lauroyl methyl taurine, sodium dodecylbenzenesulfonate, α-sulfo fatty acid alkyl ester / sodium, alkyl phosphate ester salts, etc. Anionic surfactants; betaine acetate type amphoteric surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyldimethylaminoacetic acid betaine; imidazoline type amphoteric such as N-fatty acid acyl-N-carboxymethyl-N-hydroxyethylethylenediamine salt Surfactant, amino acid type amphoteric surfactant such as N-fatty acid acyl-L-alginate salt; polyglycerin fatty acid ester, sugar fatty acid ester, sorbitan fatty acid ester, polyoxyethylene poly Carboxymethyl propylene block copolymer, polyoxyethylene fatty acid esters, fatty acid monoglyceride, non-ionic surfactants such as polyoxyethylene alkyl ether.
The compounding amount of the surfactant is usually 0 to 10%, particularly 0.1 to 5%.

Examples of the preservative include paraoxybenzoic acid esters such as methylparaben, ethylparaben, propylparaben, and butylparaben, benzoic acid such as sodium benzoate or salts thereof, alkyldiaminoethylglycine hydrochloride, potassium sorbate, and the like.
Examples of the sweetening agent include saccharin sodium, steviosite, sucralose and the like.
Examples of the coloring agent include highly safe water-soluble pigments such as Blue No. 1, Green No. 3, Yellow No. 4, and Red No. 105.

Natural flavors such as peppermint oil, spearmint oil, eucalyptus oil, wintergreen oil, clove oil, thyme oil, sage oil, cardamom oil, rosemary oil, marjoram oil, lemon oil, nutmeg oil, lavender oil, paracres oil, etc. Essential oils and perfume ingredients contained in the above natural essential oils such as l-carvone, 1,8-cineol, methyl salicylate, eugenol, thymol, linalool, limonene, menthone, menthyl acetate, citral, camphor, borneol, pinene, spirantol Also, ethyl acetate, ethyl butyrate, isoamyl acetate, hexanal, hexenal, methyl anthranilate, ethyl methyl phenyl glycidate, benzaldehyde, vanillin, ethyl vanillin, furaneol, malto , Perfume ingredients such as ethyl maltol, gamma / delta decalactone, gamma / deltown decalactone, N-ethyl-p-menthane-3-carboxamide, menthyl lactate, ethylene glycol-l-menthyl carbonate, Flavors such as apple, banana, strawberry, blueberry, melon, peach, pineapple, grape, muscat, wine, cherry, squash, coffee, brandy, yogurt and the like.
The blending amount is not particularly limited, but the above fragrance material is preferably used in the composition in an amount of 0.000001 to 1%, and the fragrance for fragrance using the above fragrance material is 0.00% in the composition. It is preferable to use 1 to 2%.

  As an active ingredient, a well-known medicinal ingredient can be added in the range which does not prevent the effect of this invention. For example, bactericides such as isopropylmethylphenol and triclosan, anti-inflammatory agents such as tranexamic acid and epsilon-aminocaproic acid, enzymes such as dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme, lytechenzyme, aluminum chlorohydroxy allantoin , Plant extracts such as allantoin, azulene, lysozyme chloride, ascorbic acid, dihydrocholesterol, glycyrrhetin salts, glycyrrhetinic acid, hydrocholesterol, chlorophyll, copper chlorophyllin sodium, thyme, ogon, clove, hamamelis, copper gluconate, caropeptide, polyphosphoric acid Sodium, polyvinylpyrrolidone, potassium nitrate, aluminum lactate and the like can be mentioned.

The viscosity of the composition for liquid oral cavity of the present invention is preferably 1 to 100 mPa · s at 25 ° C. (measured value with a B-type viscometer).
Moreover, PET (polyethylene terephthalate), glass, polypropylene, polyethylene, etc. can be used for the material of the container filled with the liquid oral composition.

  EXAMPLES Hereinafter, although an Example, a comparative example, a formulation example is shown and this invention is demonstrated concretely, this invention is not restrict | limited to the following Example. In the following examples, “%” means “% by mass” unless otherwise specified. In addition, pH and a viscosity are the values in 25 degreeC, and the viscosity was measured with the following method.

[Examples and Comparative Examples]
(1) Experiment 1
Liquid oral compositions (mouth washes) having the compositions shown in Tables 1 to 3 were prepared by the following method, and the effectiveness (gum tightness) was evaluated according to the following method. The results are shown in the table.
In addition, (B) component was mix | blended as a fluorine-containing compound shown in a table | surface, and content of a fluorine ion was shown in () as a fluorine ion concentration (ppm). In addition, (a + b) / c is the mass ratio of the content (a) of the component (A), the sum of the content (b) of the component (B) and the content c of the component (C) (where b is (B) It is equivalent to sodium fluoride converted from the content of fluorine ions.

A method for preparing a liquid oral composition;
Ascorbic acid phosphates and other components were mixed with 850 g of purified water at room temperature and stirred for 1 hour until the ascorbic acid phosphates were completely dissolved. After adjusting the pH by adding sodium hydroxide, hydrochloric acid or the like as necessary, purified water was added so that the total amount of the composition was 1,000 g. In addition, sodium hydroxide and hydrochloric acid used what prepared 10% aqueous solution.

Evaluation method of effectiveness (feeling of tightening gums);
About 10 ml of a sample (composition for liquid oral cavity) was included in the mouth, and after squeezing for 30 seconds, the sensory evaluation of the effective feeling (feeling of tightening the gums) after mouthwashing was carried out based on the following four grades. An average value of the evaluation results of 10 people was obtained and evaluated according to the following criteria. ○ The above was accepted.
Evaluation criteria (feeling of tightening the gums):
4 points: There was a feeling of tightening the gums.
3 points: There was a slight feeling of tightening the gums.
2 points: There was almost no feeling of tightening the gums.
1 point: There was no feeling of tightening the gums.
Criteria for effectiveness (feeling of tightening gums):
◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average point 2.0 points Less than

Viscosity measurement method;
It was measured with a B-type viscometer (rotor No. 1, 60 rpm, 25 ° C., measured value after 1 minute).

(2) Experiment 2
A liquid oral composition (mouthwash) having the composition shown in Table 4 was prepared in the same manner as described above, and the feeling of effectiveness (feeling of tightening gums) was evaluated. Further, the feeling of use was evaluated according to the following method. The results are shown in the table.

Evaluation method of feeling of use (astringency, bitterness, tastelessness);
About 10 ml of sample (composition for liquid oral cavity) is put in the mouth, and after squeezing for 30 seconds, the feeling after use (astringency, bitterness, tastelessness) is organoleptically evaluated based on the following four grades. did. An average value of the evaluation results of 10 people was obtained and evaluated according to the following criteria. ○ The above was accepted.
Usability rating criteria 4 points: No astringency, bitterness, or off-flavor.
3 points: There are slight astringency, bitterness and off-flavor.
2 points: There is a bit of astringency, bitterness, and taste.
1 point: Astringency, bitterness, and off-taste are considerable.
Judgment criteria for feeling of use ◎: Average point 3.5 points or more and 4.0 points or less ○: Average point 3.0 points or more and less than 3.5 points △: Average point 2.0 points or more and less than 3.0 points ×: Average Less than 2.0 points

Details of the raw materials used are shown below.
(A) L-ascorbyl magnesium phosphate: manufactured by Wako Pure Chemical Industries, Ltd., for biochemistry (A) L-ascorbyl phosphate sodium:
DSM Nutrition Japan Co., Ltd., Stay C5
(B) Sodium fluoride: manufactured by Stella Chemifa Corporation, sodium fluoride (B) sodium monofluorophosphate: manufactured by Rhodia Nikka Co., Ltd. (C) monosodium dihydrogen phosphate: manufactured by Taihei Chemical Industrial Co., Ltd. Sodium dihydrogen phosphate (C) Disodium monohydrogen phosphate: manufactured by Taihei Chemical Industry Co., Ltd. Sodium monohydrogen phosphate, sodium tripolyphosphate (comparative product): manufactured by Taihei Chemical Industrial Co., Ltd., sodium polyphosphate (D ) Glycerin: Sakamoto Pharmaceutical Co., Ltd. (D) Sorbitol: Wako Pure Chemical Industries, Ltd. (D) Propylene glycol: Asahi Glass Co., Ltd.

  A prescription example is shown below.

[Formulation Example 1] Mouthwash (A) L-ascorbyl magnesium phosphate 0.3%
(B) Sodium fluoride 0.05
(Fluorine ion concentration 226ppm)
(C) Monosodium dihydrogen phosphate 0.1
(D) Glycerin 4
Polyoxyethylene hydrogenated castor oil (60) 0.5
Citric acid 0.07
Sodium citrate 0.25
Sodium hydroxide 0.08
Fragrance 0.2
Purified water balance <br/> Total 100.0%
(A + b) /c=3.5, pH (25 ° C.); 7.5

[Prescription Example 2] Mouthwash (A) L-ascorbyl magnesium phosphate 0.3%
(B) Sodium fluoride 0.02
(Fluorine ion concentration 90ppm)
(C) Monosodium dihydrogen phosphate 0.1
(D) Glycerin 4
Polyoxyethylene hydrogenated castor oil (60) 0.5
Citric acid 0.07
Sodium citrate 0.25
Sodium hydroxide 0.08
Fragrance 0.2
Purified water balance <br/> Total 100.0%
(A + b) /c=3.2, pH (25 ° C.); 7.5

[Formulation Example 3] Mouthwash (A) L-ascorbyl magnesium phosphate 0.3%
(B) Sodium monofluorophosphate 0.05
(Fluorine ion concentration 66ppm)
(C) Monosodium dihydrogen phosphate 0.1
(D) Glycerin 4
Polyoxyethylene hydrogenated castor oil (60) 0.5
Citric acid 0.07
Sodium citrate 0.25
Sodium hydroxide 0.08
Fragrance 0.2
Purified water balance <br/> Total 100.0%
b = 0.015%, (a + b) /c=3.15, pH (25 ° C.); 7.5

Claims (8)

(A) 0.1-1% by mass of ascorbic acid phosphate and / or salt thereof,
(B) Fluorine ion 5-4,530 ppm,
(C) Orthophosphoric acid and / or salt thereof 0.01 to 1% by mass
A composition for liquid oral cavity, comprising   (B) The liquid oral composition according to claim 1, wherein the fluorine ion source is one or more fluorine-containing compounds selected from sodium fluoride, sodium monofluorophosphate and tin fluoride.   Component (C) is a hydrogen salt of one or more orthophosphoric acids selected from monosodium dihydrogen phosphate, disodium monohydrogen phosphate, monopotassium dihydrogen phosphate and dipotassium monohydrogen phosphate. The composition for liquid oral cavity according to claim 1 or 2.   (A) component content a, (B) component content b and (C) component content c (a + b) / c (where b is (B) fluorine ion The liquid oral composition according to claim 1, 2 or 3, wherein the sodium fluoride equivalent amount converted from the content is 0.35 to 40 as a mass ratio.   Furthermore, the liquid oral cavity composition of any one of Claims 1-4 formed by containing 0.1-20 mass% of (D) polyhydric alcohol and / or sugar alcohol.   The liquid oral composition according to any one of claims 1 to 5, wherein the pH at 25 ° C is 6.5 to 8.   The composition for liquid oral cavity according to any one of claims 1 to 6, which does not contain an abrasive.   It is a mouthwash, The liquid oral cavity composition of any one of Claims 1-7.