JP2015189762A - Oil-in-water emulsion composition - Google Patents

Abstract

An object of the present invention is to provide an oil-in-water emulsified composition having a feeling of use (dense and heavy moist feeling), less stickiness, and excellent stability. And In an oil-in-water emulsion composition, (A) a polyglycerin fatty acid ester, (B) an anionic surfactant, (C-1) stearyl alcohol, (C-2) behenyl alcohol, and (D) lecithin. And by setting the content of (A) polyglycerin fatty acid ester, (B) anionic surfactant, (C-1) stearyl alcohol and (C-2) behenyl alcohol within a predetermined range Although it is a feeling of use, there is little stickiness and high stability can be provided. [Selection figure] None

Description

  The present invention relates to an oil-in-water emulsion composition. More specifically, the present invention relates to an oil-in-water emulsified composition having a small feeling of stickiness and excellent stability while having a feeling of use (a rich and heavy moist feeling).

  Conventionally, a cream-like oil-in-water emulsion composition is stabilized by forming an α-gel in the system with a nonionic surfactant and a higher aliphatic alcohol. Therefore, a cream-like oil-in-water emulsion composition requires a sufficient amount of α-gel to be present in the system in order to ensure the stability of the preparation. Usually, many nonionic surfactants and high-grade surfactants are required. Contains fatty alcohol. However, although the α-gel present in the preparation contributes to the improvement of the preparation stability, it has a drawback of giving a sticky feeling when applied to the skin.

  An oil-in-water emulsion composition in which a higher aliphatic alcohol and a gel are produced by using an anionic surfactant instead of a nonionic surfactant as a pharmaceutical formulation for improving the disadvantages of the α-gel. It has been reported (Patent Document 1). However, the oil-in-water emulsified composition disclosed in Patent Document 1 has a refreshing and light feeling of use, and is not satisfactory for a user who desires a rough feeling of use.

  It has also been reported that an oil-in-water emulsion composition having excellent stability over time and good usability can be obtained by adjusting the blending amount of the nonionic surfactant and the higher aliphatic alcohol within a predetermined range. (Patent Document 2). However, the oil-in-water emulsified composition disclosed in Patent Document 2 has a light feeling of use and cannot satisfy a user who requires a pleasing feeling of use. Further, depending on the nonionic surfactant to be used, the temperature is high. There were problems such as poor stability.

  As described above, in the prior art, an oil-in-water emulsion composition that has a feeling of use but is less sticky has not been developed.

JP 2001-348325 A JP 2001-97816 A

  An object of the present invention is to provide an oil-in-water emulsion composition that has a feeling of use but has little stickiness and excellent stability.

  As a result of diligent studies to solve the above problems, the present inventors have found that in an oil-in-water emulsion composition, (A) a polyglycerol fatty acid ester, (B) an anionic surfactant, (C-1) stearyl Alcohol, (C-2) behenyl alcohol, and (D) lecithin, and (A) polyglycerin fatty acid ester, (B) anionic surfactant, (C-1) stearyl alcohol, and (C-2) behenyl alcohol It has been found that by setting the content of to a predetermined range, there is little stickiness and high stability even though it has a feeling of use. Furthermore, it has been found that when a liposome containing natural lecithin and hydrogenated lecithin is used as (D) lecithin and a functional ingredient is blended with the liposome, the permeation of the functional ingredient into the skin and skin familiarity are improved. It was. The present invention has been completed by further studies based on these findings.

That is, this invention provides the oil-in-water emulsion composition of the aspect hung up below.
Item 1. (A) polyglycerin fatty acid ester, (B) anionic surfactant, (C-1) stearyl alcohol, (C-2) behenyl alcohol, and (D) lecithin, and (A) polyglycerin fatty acid ester The content is 0.5 to 1.2% by weight, the content of (B) anionic surfactant is 0.1 to 0.8% by weight, and the content of (C-1) stearyl alcohol is (C -2) An oil-in-water emulsified composition characterized in that it is more than behenyl alcohol.
Item 2. Item 2. The oil-in-water emulsion composition according to Item 1, wherein 1.5 to 5 parts by weight of the (C-1) stearyl alcohol is contained with respect to 1 part by weight of the (C-2) behenyl alcohol.
Item 3. Item 3. The oil-in-water emulsion composition according to Item 1 or 2, which contains at least hydrogenated lecithin as the (D) lecithin.
Item 4. Item 4. The oil-in-water emulsion composition according to any one of Items 1 to 3, wherein the (D) lecithin is contained in a liposome form containing hydrogenated lecithin and natural lecithin.
Item 5. Item 5. The oil-in-water emulsion composition according to Item 4, wherein 20 to 130 parts by weight of the hydrogenated lecithin is contained with respect to 1 part by weight of the natural lecithin.
Item 6. Item 6. The oil-in-water emulsion composition according to any one of Items 4 and 5, wherein a lower alcohol extract of egg yolk is used as the natural lecithin.
Item 7. Item 7. The oil-in-water emulsion composition according to any one of Items 4 to 6, further comprising an egg yolk lower alcohol extract separately from the liposome form (D) lecithin.
Item 8. Item 8. The oil-in-water emulsion composition according to any one of Items 1 to 7, which is a creamy cosmetic.

The oil-in-water emulsified composition of the present invention has a feeling of use but a little stickiness, and a unique, good or usability that cannot be realized with a conventional oil-in-water emulsion composition can be obtained. Moreover, the oil-in-water emulsion composition of the present invention is excellent in stability, and can maintain an emulsified state stably even when stored at high temperature conditions or for a long period of time. Furthermore, in the oil-in-water emulsion composition of the present invention, by using a liposome containing natural lecithin and hydrogenated lecithin as the lecithin to be contained, functional components such as hyaluronic acid or a hydrolyzate thereof penetrate into the skin. The feeling and familiarity with the skin can be significantly improved.

  The oil-in-water emulsion composition of the present invention contains (A) polyglycerin fatty acid ester, (B) anionic surfactant, (C-1) stearyl alcohol, (C-2) behenyl alcohol, and (D) lecithin. And (A) the content of polyglycerol fatty acid ester is 0.5 to 1.2% by weight, (B) the content of anionic surfactant is 0.1 to 0.8% by weight, and (C -1) The content of stearyl alcohol is higher than that of (C-2) behenyl alcohol. Hereinafter, the oil-in-water emulsion composition of the present invention will be described in detail.

(A) Polyglycerol fatty acid ester The oil-in-water emulsion composition of the present invention contains a polyglycerol fatty acid ester. The polyglycerin fatty acid ester used in the present invention is not particularly limited, but a hydrophilic one is preferable in order to realize a feeling of use, lack of stickiness, and improvement in stability. Specific examples of such hydrophilic polyglycerin fatty acid esters include those having an HLB of 10 or more, preferably 10 to 15.

  Although it does not restrict | limit especially about the kind of polyglyceryl fatty acid ester used by this invention, For example, the ester body of polyglycerin with a polymerization degree of 6 or more and a C6-C22 linear or branched fatty acid is mentioned. It is done.

  Specific examples of the polyglycerol fatty acid ester include esters of a fatty acid having 12 to 36 carbon atoms and a polyglycerol having a polymerization degree of 6 or more, particularly 6 to 10 carbon atoms. The fatty acid that forms an ester with polyglycerin may be a saturated, unsaturated, linear or branched fatty acid, specifically capric acid, lauric acid, isotridecanoic acid, myristic acid, palmitic acid. , Palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, behenic acid, ricinoleic acid and the like.

  Among these polyglycerin fatty acid esters, from the viewpoint of further improving the feeling of use, non-stickiness, and stability, polyglyceryl-6 laurate, polyglyceryl-6 myristate, polyglyceryl stearate- 6, polyglyceryl oleate-6, polyglyceryl-10 laurate, polyglyceryl-10 myristate, polyglyceryl-10 stearate, decaglyceryl monooleate, polyglyceryl oleate-10.

  These polyglycerin fatty acid esters may be used alone or in combination of two or more.

  In the oil-in-water emulsion composition of the present invention, the content of the polyglycerol fatty acid ester is set in the range of 0.5 to 1.2% by weight. By satisfying such a range, it is possible to provide a feeling of use with little stickiness while having an excellent feeling of use, and to have excellent stability. The content of the polyglycerin fatty acid ester is preferably from 0.5 to 1.0% by weight, more preferably from 0.5 to 1.0%, from the viewpoint of further improving the sense of use, non-stickiness, and stability. 0.8% by weight is mentioned.

(B) Anionic surfactant The oil-in-water emulsion composition of the present invention contains anionic surfactant. The anionic surfactant used in the present invention is not particularly limited, but a hydrophilic one is preferable in order to realize a feeling of use, no stickiness, and improved stability. Specific examples of such hydrophilic anionic surfactants include those having an HLB of 10 or more, preferably 10-15.

  The type of the anionic surfactant is not particularly limited. For example, N-acyl-L-glutamate having a linear alkyl group having 16 or more carbon atoms, monoalkyl having a linear alkyl group having 16 or more carbon atoms. A phosphate etc. are mentioned. Among these anionic surfactants, N-stearoyl sodium glutamate, N-palmitoyl glutamate, and N-stearoyl are preferable from the viewpoint of further improving the feeling of use, non-stickiness, and stability. Examples include triethanolamine glutamate and sodium cetyl phosphate.

  These anionic surfactants may be used individually by 1 type, and may be used in combination of 2 or more type.

  In the oil-in-water emulsion composition of the present invention, the content of the anionic surfactant is set in the range of 0.1 to 0.8% by weight. By satisfying such a range, it is possible to provide a feeling of use with little stickiness while having an excellent feeling of use, and to have excellent stability. The content of the anionic surfactant is preferably 0.1 to 0.5% by weight from the viewpoint of further improving the feeling of use, non-stickiness, and stability.

(C-1) Stearyl alcohol and (C-2) Behenyl alcohol The oil-in-water emulsion composition of the present invention contains stearyl alcohol and behenyl alcohol.

  In the oil-in-water emulsion composition of the present invention, the content of stearyl alcohol is set to be higher than that of behenyl alcohol. By containing stearyl alcohol and behenyl alcohol at such a content, it is possible to realize a feeling of use, a lack of stickiness, and an improvement in stability. Stearyl alcohol is preferably 1.5 to 5 parts by weight with respect to 1 part by weight of behenyl alcohol from the viewpoint of further improving the sense of use, non-stickiness, and stability as the ratio of stearyl alcohol to behenyl alcohol. More preferred is 2 to 4 parts by weight, and particularly preferred is 2.5 to 3.5 parts by weight.

  In the oil-in-water emulsion composition of the present invention, the content of stearyl alcohol and behenyl alcohol may be appropriately set within a range that satisfies the above-described ratio, but specifically, the content of stearyl alcohol is preferably 1 0.5 to 6% by weight, more preferably 2 to 5% by weight, and the content of behenyl alcohol is preferably 0.8 to 2% by weight, and more preferably 1 to 1.5% by weight.

(D) Lecithin The oil-in-water emulsion composition of the present invention contains lecithin. Specific examples of lecithin used in the present invention include natural lecithin and hydrogenated lecithin. These lecithins may be used individually by 1 type, and may be used in combination of 2 or more type. Among these lecithins, it is preferable to contain at least hydrogenated lecithin from the viewpoint of further improving the feeling of use, lack of stickiness, and stability.

(Hydrogenated lecithin)
Hydrogenated lecithin is lecithin in which at least part of unsaturated double bonds are converted to saturated bonds by hydrogenation treatment of natural lecithin. Hydrogenated lecithin has reduced unsaturated double bonds, and the iodine value is usually 10 or less. As the hydrogenated lecithin used in the present invention, the iodine value of the hydrogenated lecithin is preferably 8 or less, more preferably 5 or less, from the viewpoint of further improving the permeation to skin, skin familiarity, and stability. More preferably, 3 or less is mentioned.

  The type of phospholipid contained in the hydrogenated lecithin is not particularly limited as long as the phospholipid exemplified for the natural lecithin is hydrogenated. Moreover, the hydrogenated lecithin used in the present invention may be composed of one phospholipid, or may be composed of a combination of two or more phospholipids. As the hydrogenated lecithin used in the present invention, the phosphatidylcholine content is 10% by weight or more, preferably 15% by weight or more from the viewpoint of further improving the feeling of use, non-stickiness, and stability. Preferably, hydrogenated lecithin is 20% by weight or more. Although the upper limit of the phosphatidylcholine content of hydrogenated lecithin is not particularly limited, it may be 99% by weight or less.

  The origin of the hydrogenated lecithin used in the present invention is not particularly limited as long as the lecithin derived from animals or plants is hydrogenated. Specific examples of the animal-derived hydrogenated lecithin include those obtained by hydrogenating animal-derived lecithin such as egg yolk lecithin and seafood-derived lecithin. Specific examples of plant-derived hydrogenated lecithin include soybean lecithin, sesame lecithin, corn lecithin, flax lecithin, olive lecithin, rice lecithin, rape lecithin, sunflower lecithin, safflower lecithin, cottonseed lecithin, kiri Examples include those obtained by hydrogenating plant-derived lecithin such as lecithin, gray lecithin, avocado lecithin, palm lecithin, palm lecithin and the like.

  These hydrogenated lecithins may be used individually by 1 type, and may be used in combination of 2 or more type. The hydrogenated lecithin used in the present invention is preferably hydrogenated soybean phospholipid, hydrogenated egg yolk lecithin, more preferably from the viewpoint of further improving the feeling of use, lack of stickiness, and stability. A hydrogenated soybean phospholipid is mentioned.

Hydrogenated lecithin is commercially available, and commercially available natural lecithin can be used in the present invention. Examples of commercially available hydrogenated lecithin include Nikko Chemicals Corporation (NIKKOL Resinol S-10, NIKKOL Resinol S-10E, NIKKOL Resinol S-10EX), NOF Corporation ( Product name: COATSOME NC-21) and the like, and examples of hydrogenated egg yolk lecithin include Kewpie Corporation (trade name: egg yolk lecithin PL-100P), NOF Corporation (trade name: COATSOME NC-11) and the like. .
(Combination of hydrogenated lecithin and natural lecithin)
When the hydrogenated lecithin and natural lecithin are used in combination, the oil-in-water emulsified composition of the invention can further improve the skin penetration feeling and skin familiarity.

  Natural lecithin is lecithin obtained from an animal or plant and containing an unsaturated fatty acid chain as a fatty acid chain. Natural lecithin contains many unsaturated double bonds, and the iodine value is usually 20 or more. In the present invention, by using natural lecithin in combination with the hydrogenated lecithin, in the oil-in-water emulsion composition of the present invention, it is possible to improve the skin penetration feeling and the skin familiarity. From the viewpoint of further improving the permeation feeling to the skin and the skin familiarity as natural lecithin, the iodine value of natural lecithin is preferably 25 or more, more preferably 30 or more. The upper limit of the iodine value of natural lecithin is usually 120 or less, preferably 100 or less, more preferably 95 or less.

  The type of phospholipid contained in natural lecithin is not particularly limited, and examples thereof include phosphatidylcholine, phosphatidylethanolamine, lysophosphatidylcholine, lysophosphatidylethanolamine, sphingomyelin, and phosphatidic acid. The natural lecithin used in the present invention may be composed of one of these phospholipids alone, or may be composed of a combination of two or more. Natural lecithin having a phosphatidylcholine content of 10% by weight or more, preferably 15% by weight or more, more preferably 20% by weight or more from the viewpoint of further improving the skin penetration feeling and skin familiarity as natural lecithin. Can be mentioned. The upper limit of the phosphatidylcholine content of natural lecithin is not particularly limited, but may be 95% by weight or less.

  The origin of natural lecithin is not particularly limited, and those derived from animals or plants exemplified for the hydrogenated lecithin can be used. The natural lecithin used in combination with the hydrogenated lecithin is preferably egg yolk lecithin, soybean lecithin, or more preferably egg yolk lecithin from the viewpoint of further improving the feeling of penetration into the skin and the feeling of familiarity with the skin.

  Natural lecithin may be a purified product, but may contain other components as long as natural lecithin is contained. In particular, when egg yolk lecithin is used, it is preferable to use a lower alcohol extract of egg yolk.

  The egg yolk lower alcohol extract is obtained by extracting egg yolk from lipids such as lecithin and other oils and fats with a lower alcohol such as ethanol and isopropanol, and includes egg yolk lecithin and other oils and fats. For the yolk lower alcohol extract, an extract obtained by extraction with lower alcohol may be used as it is, or a dried and solidified extract may be used as necessary. Furthermore, the dried and solidified extract may be further subjected to an extraction treatment with a lower alcohol to use a product obtained by reducing or removing lipids and fat components other than lecithin. The yolk lower alcohol extract preferably contains 15% by weight or more of egg yolk lecithin, preferably 20% by weight or more, and more preferably 25% by weight or more. The lower alcohol extract of egg yolk contains fats and oils other than lecithin, and by combining this with the hydrogenated lecithin, the skin penetration and skin familiarity can be more effectively improved. Is possible.

  Natural lecithin is commercially available, and commercially available natural lecithin can be used in the present invention. Commercially available natural lecithin includes, for example, NOF Corporation (trade name: COATSOME NC-20 (SPC)), Lipoid (trade name: LIPOID P100), etc. as soy lecithin, and egg yolk lecithin. NOF Corporation (trade name: COATSOME NC-50 (EPC)), Lipoid (trade name: LIPOID E PC S), QP Corporation (trade name: egg yolk lecithin PL-30S), and the like.

  In the oil-in-water emulsion composition of the present invention, when hydrogenated lecithin and natural lecithin are used in combination as lecithin, these ratios are not particularly limited. For example, hydrogenated lecithin is added to 1 part by weight of natural lecithin. It is preferably 20 to 130 parts by weight, more preferably 30 to 100 parts by weight, and still more preferably 35 to 85 parts by weight. By satisfying such a ratio, it is possible to further improve the skin penetration feeling and the skin familiarity.

  In addition, when hydrogenated lecithin and natural lecithin are used in combination, these may each be included alone in the oil-in-water emulsion composition of the present invention, but included in a state where liposomes are formed with hydrogenated lecithin and natural lecithin. It is preferable that Thus, by forming liposomes with hydrogenated lecithin and natural lecithin, it is possible to further improve the skin penetration and skin familiarity.

  In the case of forming liposomes with hydrogenated lecithin and natural lecithin, the content of hydrogenated lecithin and natural lecithin in the liposome is not particularly limited. For example, per 100 parts by weight of the total amount of liposome membrane constituents, natural lecithin and The total amount of hydrogenated lecithin is 20 to 100 parts by weight, preferably 30 to 100 parts by weight, and more preferably 40 to 100 parts by weight.

  In the case of forming liposomes with hydrogenated lecithin and natural lecithin, other components are included as membrane constituents as necessary, in addition to natural lecithin and hydrogenated lecithin, as long as they do not interfere with the effects of the present invention. Also good. Examples of such membrane constituents include phospholipid polymers, sterols, charged substances, acylamino acid surfactants, and the like.

  Examples of the phospholipid polymer include polymethacryloyloxyethyl phosphorylcholine, 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer, 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate / sodium methacrylate copolymer, 2-methacryloyl Examples thereof include oxyethyl phosphorylcholine · 2-hydroxy-3-methacryloyloxypropyltrimethylammonium chloride copolymer and 2-methacryloyloxyethyl phosphorylcholine · stearyl methacrylate copolymer. Among these phospholipid polymers, a 2-methacryloyloxyethyl phosphorylcholine / butyl methacrylate copolymer is preferable. These phospholipid polymers may be used individually by 1 type, and may be used in combination of 2 or more type.

  Examples of sterols include cholesterol, cholesteryl acetate, cholesteryl nonate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, phytosteryl stearate, phytosteryl stearate, phytosteryl oleate, phytosteryl palmitate, soft lanolin fatty acid cholesteryl, hard Lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl, N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl 2-octyldodecyl), 12-hydroxystearin Cholesteryl, and the like. These sterols may be used individually by 1 type, and may be used in combination of 2 or more type.

  Examples of the charged substance include fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, elaidic acid, eleostearic acid, and 2,4-octadecadienoic acid; their sodium salts, potassium salts, Fatty acid salts such as calcium salts and ammonium salts; phosphatidic acid, dicetyl phosphate and the like. Further, when phosphatidylglycerol or a salt thereof is used as a phospholipid component, it itself acts as a charged substance. These charged substances may be used alone or in combination of two or more.

  Examples of the acylamino acid surfactant include fatty acid amide salts of amino acids such as sarcosine, glutamic acid, taurine, glycine and the like. These acylamino acid surfactants may be used alone or in combination of two or more.

  When a liposome is formed from hydrogenated lecithin and natural lecithin, the liposome may contain a functional component exhibiting cosmetic or pharmaceutical functionality, if necessary, in an internal aqueous phase (internal phase of the liposome) and / or Alternatively, it may be contained inside the membrane (in the liposome membrane). The types of such functional components are as described in the column “(H) Functional component” described later. Among functional ingredients, hyaluronic acid or its hydrolyzate is a functional ingredient that is difficult to satisfy both skin penetration and familiarity with conventional techniques, but is formed by hydrogenated lecithin and natural lecithin. According to the liposome, both the penetration of hyaluronic acid or its hydrolyzate into the skin and the familiarity with the skin can be effectively improved. In view of the effect of the present invention, the functional component contained in the liposome is preferably hyaluronic acid or a hydrolyzate thereof, more preferably a hydrolyzate of hyaluronic acid. The average molecular weight of the hydrolyzate of hyaluronic acid is not particularly limited, and examples thereof include 10,000 or less.

  In the liposome formed of hydrogenated lecithin and natural lecithin, the content of the functional component is appropriately set according to the type of the functional component used. For example, the total amount of membrane constituent components of the liposome is 100% by weight. A functional component is 0.01-35 weight part per part, Preferably 0.1-25 weight part, More preferably, 0.5-20 weight part is mentioned.

  In addition, when liposomes are formed from hydrogenated lecithin and natural lecithin, the liposomes contain oils and additives blended in the composition for external skin as necessary, in the inner aqueous phase and / or inside the membrane. It may be. The types of such oils and additives are as described in the columns of “(F) Other oils” and “(I) Other additives” described later.

  When liposomes are formed with hydrogenated lecithin and natural lecithin, membrane constituent components, water, functional components and additives added as necessary may be mixed and used for a known liposome forming method. The liposome formation method is not particularly limited. For example, a method using a homogenizer, a microfluidizer, a vacuum emulsifier, an ultrasonic treatment method, a French press method, a freeze-thaw method, a reverse phase evaporation method, a surfactant method. , Extrusion method, calcium-EDTA chelate method and the like.

  The average particle size of the liposome formed by hydrogenated lecithin and natural lecithin is not particularly limited, and examples include about 50 to 500 nm.

(Lecithin content)
The content of lecithin in the oil-in-water emulsion composition of the present invention is not particularly limited. For example, lecithin is 0.00005 to 5% by weight in total, preferably 0.0001 to 3% by weight, and more preferably 0. The range which becomes 0.001 to 2weight% is mentioned. By satisfying such a range, it is possible to further improve the feeling of use, the non-stickiness, and the stability.

(E) oil-in-water emulsion composition of the water present invention contains water to form an aqueous phase. The water content in the oil-in-water emulsion composition of the present invention is appropriately set according to the dosage form of the oil-in-water emulsion composition of the present invention, and is, for example, 40 to 85% by weight, preferably 50 to 50%. 80% by weight, more preferably 55-80% by weight.

(F) Other oil components In addition to the components described above, the oil-in-water emulsified composition of the present invention contains, as necessary, hydrocarbons, fatty acid alkyl esters, fatty acids, vegetable oils, animal oils, higher alcohols (other than stearyl alcohol and behenyl alcohol). Oils such as silicone oil may be included.

  Specific examples of the hydrocarbon include paraffin, liquid paraffin, gelled hydrocarbon (such as plastic base), petrolatum, mineral oil (mineral oil), and the like. These hydrocarbons may be used individually by 1 type, and may be used in combination of 2 or more type.

  Examples of the fatty acid alkyl ester include esters of fatty acids having 6 to 20 carbon atoms and alcohols having 2 to 20 carbon atoms. Specifically, cetyl ethylhexanoate, diisopropyl adipate, isopropyl myristate, isopropyl palmitate Cetyl palmitate, diethyl sebacate, ethyl oleate and the like. These fatty acid alkyl esters may be used alone or in combination of two or more.

  Examples of the fatty acid include fatty acids having 8 to 20 carbon atoms, and specific examples include stearic acid, lauric acid, myristic acid, palmitic acid, sebacic acid, and oleic acid. These fatty acids may be used alone or in combination of two or more.

  Specific examples of vegetable oils include olive oil, wheat germ oil, rice oil, safflower oil, soybean oil, camellia oil, corn oil, rapeseed oil, sunflower oil, cottonseed oil, peanut oil, jojoba fat, hydrogenated oil, avocado oil, Examples include fennel oil, clove oil, mint oil, eucalyptus oil, lemon oil, carnauba wax, candelilla wax, rice bran wax, beeswax, and wood wax. These vegetable oils may be used individually by 1 type, and may be used in combination of 2 or more type.

  Specific examples of animal oils include lard, fish oil, squalane and the like. These animal oils may be used alone or in combination of two or more.

  Examples of higher alcohols include monohydric alcohols having 8 to 20 carbon atoms, and specific examples include myristyl alcohol, cetyl alcohol, hexadecyl alcohol, lanolin alcohol, and the like. These higher alcohols may be used alone or in combination of two or more.

  Specific examples of the silicone oil include methylpolysiloxane, cross-linked methylpolysiloxane, cyclic silicone, alkyl-modified silicone, amino-modified silicone, polyether-modified silicone, polyglycerin-modified silicone, acrylic silicone, and phenyl-modified silicone. It is done. These silicone oils may be used alone or in combination of two or more.

  Among these oils, animal oil, mineral oil, fatty acid alkyl ester, fatty acid glycerin ester, fatty acid and higher alcohol are preferable from the viewpoint of further improving the feeling of use, lack of stickiness, and stability. . These oil components may be used alone or in combination of two or more.

  In the oil-in-water emulsion composition of the present invention, the content of these oils is not particularly limited, but for example, 5 to 50% by weight, preferably 5 to 40% by weight, more preferably 5 to 30% by weight. Can be mentioned.

(G) Lower alcohol extract of egg yolk The oil-in-water emulsion composition of the present invention may contain a lower alcohol extract of egg yolk as necessary. Thus, by including the lower alcohol extract of egg yolk, the penetration feeling into the skin and the skin familiarity of the oil-in-water emulsion composition of the present invention can be improved. In particular, when a liposome formed from hydrogenated lecithin and natural lecithin is used as lecithin, a yolk lower alcohol extract is contained separately from the liposome, and the egg yolk lower alcohol is contained in the oil-in-water emulsion composition. By allowing the extract to exist in a form that is not incorporated into liposomes, it is possible to remarkably improve the feeling of use, lack of stickiness, feeling of penetration into the skin, and feeling of familiarity with the skin. The lower alcohol extract of egg yolk is as described in the column of “Natural lecithin”.

  Further, the content of the egg yolk lower alcohol extract of the oil-in-water emulsion composition of the present invention (the amount added separately from the liposome formed by hydrogenated lecithin and natural lecithin) is not particularly limited, In terms of dry weight, 0.001 to 5% by weight, preferably 0.001 to 3% by weight, and more preferably 0.001 to 2% by weight.

(H) Functional component The oil-in-water emulsion composition of the present invention may contain a functional component exhibiting cosmetic or pharmaceutical functionality, if necessary. Such functional components are not particularly limited, and examples thereof include water-soluble vitamins and derivatives thereof, oil-soluble vitamins and derivatives thereof, glycyrrhizic acid and derivatives thereof, glycyrrhetinic acid and derivatives thereof, astaxanthin, coenzyme Q10, α -Lipoic acid, ceramide or similar substances, linoleic acid, arbutin, tranexamic acid, kojic acid, enzymes, peptides, hormones, various cytokines, hyaluronic acid and other glycosaminoglycans and their salts or derivatives, hyaluronic acid hydrolysis Products, collagen or hydrolysates thereof, elastin or hydrolysates thereof, physiologically active substances such as sugars, various animal and plant extracts, substances obtained by fermentation by microorganisms, steroids, antihistamines, local anesthetics, anti-inflammatory agents, Antibacterial agent, antibacterial agent, antipruritic agent, skin protectant, Row promoter, sterols and the like. In the oil-in-water emulsion composition of the present invention, when using liposomes formed from hydrogenated lecithin and natural lecithin as lecithin, as described above, these functional components are contained in the internal aqueous phase of the liposome and / or Alternatively, it may be contained inside the membrane.

  These functional components may be used individually by 1 type, and may be used in combination of 2 or more type.

  In the oil-in-water emulsion composition of the present invention, the content of these functional components is not particularly limited, but is, for example, 0.0003 to 10% by weight, preferably 0.0003 to 8% by weight, more preferably 0.0005-8 weight% is mentioned.

(I) Other additives The oil-in-water emulsified composition of the present invention includes, in addition to the above-described components, additives that are blended in the composition for external use of the skin as necessary, as long as the effects of the present invention are not hindered. It may be included. Examples of such additives include lower monohydric alcohols such as ethanol and isopropanol; polyhydric alcohols such as glycerin and propylene glycol; antioxidants such as dibutylhydroxytoluene and sulfite; phenoxyethanol, octoxyglycerin, and parabens. Preservatives such as: phospholipid polymers, pigments, pearling agents, thickeners, surfactants (other than anionic surfactants), stabilizers, chelating agents, coloring agents, fragrances, buffers, pH adjusters Etc.

Production Method The oil-in-water emulsion composition of the present invention can be produced according to a known oil-in-water emulsion composition production method. Specifically, the components to be blended are divided into a water-soluble component and a fat-soluble component, and an aqueous phase containing a water-soluble component and an oil phase containing a fat-soluble component are prepared, respectively, and the obtained water phase and oil phase are obtained. Are mixed and emulsified by an emulsification technique such as a homogenizer, and the oil-in-water emulsion composition of the present invention can be produced.

Dosage Form and Formulation Form The oil-in-water emulsion composition of the present invention may be in any form such as liquid, solid, cream or gel. Among these dosage forms, a cream form is preferable from the viewpoint of making it easier to realize a feeling of penetration into the skin and a feeling of familiarity with the skin.

  The oil-in-water emulsified composition of the present invention is used as an external composition for skin such as cosmetics and external medicines. The formulation form of the oil-in-water emulsion composition of the present invention is not particularly limited. For example, cosmetics such as creams, lotions, cosmetics, emulsions, gels, lipsticks, foundations, etc .; liquids (lotions, sprays, (Including aerosols and emulsions), external preparations such as foams, ointments, creams, gels, patches and the like. Among these preparation forms, from the viewpoint of facilitating the feeling of penetration into the skin and the feeling of familiarity with the skin, cosmetics are preferable, and creams, cosmetic liquids, and emulsions are more preferable.

  EXAMPLES The present invention will be described more specifically with reference to the following examples, but the present invention is not limited to these examples.

Test example 1
Creamy oil-in-water emulsion compositions having the compositions shown in Tables 1 and 2 were prepared. Specifically, an oil phase in which each component (A) shown in 2 and 2 is heated to 80 ° C. and mixed, and an aqueous phase in which each component (B) shown in 2 is heated to 80 ° C. and mixed are mixed. Prepare the oil phase and the water phase, respectively, mix and emulsify using a homomixer, stir and cool to 40 ° C, add a predetermined amount of hydrogenated soybean lecithin, and further cool to 30 ° C with stirring. Thus, a creamy oil-in-water emulsion composition was produced.

  About each obtained oil-in-water type emulsion composition, the following methods evaluated the formulation stability, the rough feeling of use, and the non-stickiness.

Formulation stability After each oil-in-water emulsion composition was stored in a dark place at 50 ° C. for 4 weeks, the appearance properties after storage were observed, and the formulation stability was evaluated according to the following criteria.
<Criteria for formulation stability>
○: No change compared to standard product (stored at 25 ° C).
(Triangle | delta): Fluidity | liquidity is seen compared with a standard product (25 degreeC storage goods).
X: Creaming or two-layer separation.

Evaluation of the feeling of lack of stickiness and stickiness 10 monitors evaluated the feeling of stickiness and feeling of stickiness of each oil-in-water emulsion composition. Specifically, about 0.5 g of each oil-in-water emulsified composition was applied to the face and evaluated for a feeling of use and a feeling of stickiness that were felt. The evaluation is “1” where there is no rich and heavy moist feeling, and there is no crisp feeling. “10”, there is a rich and heavy moist feeling, and there is a crisp feeling. ”; It was carried out by conducting a questionnaire by Visual Analogue Scale (hereinafter referred to as VAS) with“ 1 ”feeling sticky and“ 10 ”not feeling sticky. The questionnaire results were averaged, and the evaluation results were summarized by rounding off the first decimal place.

  The obtained results are shown in Tables 1 and 2. As is apparent from Table 2, when stearoyl glutamic acid was not included, a rough feeling of use was insufficient and stickiness was strongly felt (Comparative Example 1). Further, when the polyglycerin fatty acid ester was not included, the preparation stability was poor, and the feeling of stickiness and stickiness were also insufficient (Comparative Example 2). Furthermore, when the polyglycerin fatty acid ester is less than 0.5% by weight, the feeling of use that is not enough is insufficient, and when the polyglycerin fatty acid ester exceeds 1.2% by weight, a strong stickiness is felt ( Comparative examples 3 and 4). In addition, when sodium stearoyl glutamate is less than 0.1% by weight, it is insufficient in terms of formulation stability, a rough feeling of use, and non-stickiness, and when it exceeds 0.8% by weight, It was insufficient in terms of a feeling of use and stickiness (Comparative Examples 5 and 6). In addition, in the case of using other nonionic surfactant (polyoxyethylene alkyl ether) instead of polyglycerin fatty acid ester, in all respects of formulation stability, a crisp feeling of use, and no stickiness, It was worse (Comparative Examples 7 and 8). In addition, when either one of behenyl alcohol and stearyl alcohol is lacking, it is insufficient in all the points of formulation stability, a rough feeling of use and non-stickiness, and behenyl alcohol has a higher content than stearyl alcohol. In some cases, a dull feeling of use was insufficient, and strong stickiness was also felt (Comparative Examples 9 to 11). Furthermore, when it did not contain lecithin, strong stickiness was felt.

  On the other hand, as is clear from Table 1, polyglycerin fatty acid ester 0.5 to 1.2% by weight, anionic surfactant (sodium stearoyl glutamate) 0.1 to 0.8% by weight, stearyl alcohol, When a smaller amount of behenyl alcohol than stearyl alcohol was contained, the preparation stability was excellent, a more comfortable use feeling was sufficiently felt, and stickiness was sufficiently suppressed (Examples 1 to 15). .

Test example 2
First, hydrogenated soybean lecithin [Nikko Chemicals, Inc., “NIKKOL Resinol S-10E”, iodine value 0.1, phosphatidylcholine content 82.2% by weight] and / or egg yolk ethanol extract (egg yolk oil) [Kupy Corporation Liposomes were produced using “Yellow yolk lecithin PL-30S”; 30% by weight of egg yolk lecithin (iodine value 73, phosphatidylcholine content 29.6% by weight) contained in the extract. Specifically, hydrogenated soybean lecithin and / or egg yolk ethanol extract mixed in a predetermined amount shown in Table 3 and heated and dispersed at 85 ° C., each of predetermined amounts shown in (B) of Table 3 The components were added to a solution obtained by heating and dissolving at 85 ° C., and homogenized at 6,000 rpm for 5 minutes at 80 ° C. (using Primix Corporation, Robotics). After the homogenization treatment, the mixture was cooled to 60 ° C. by air cooling, then water-cooled to room temperature to obtain a liposome composition.

  Using the obtained liposome composition, a creamy oil-in-water emulsion composition having the composition shown in Table 4 was prepared. The production method and composition are the same as in Example 2 except that a liposome composition was used instead of hydrogenated soybean lecithin.

  The obtained oil-in-water emulsion composition was evaluated for a feeling of use, lack of stickiness, skin familiarity, and penetration. Specifically, about 0.5 g of each oil-in-water emulsified composition was applied to the face and evaluated for a feeling of use, a feeling of stickiness, skin familiarity, and a penetrating feeling. For each evaluation, “1” indicates that there is no rich and heavy moist feeling, and there is no feeling of use, and “1” indicates that it is rich and heavy, and there is a feeling of use. “10”; feels sticky “1”, does not feel sticky “10”; feels bad skin familiarity “1”, feels good skin familiarity “10”; feels poor penetration “1” "A feeling of good penetration" was set to "10", and the questionnaire was conducted by VAS. The questionnaire results were averaged, and the evaluation results were summarized by rounding off the first decimal place.

  Table 4 shows the obtained results. It was confirmed that by adding hydrogenated soybean lecithin in the form of liposomes, the feeling of use that was slightly improved was improved (Example 16). In particular, when hydrogenated soybean lecithin and egg yolk ethanol extract (egg yolk lecithin) are used together to form liposomes, and when this is added, in all respects of feeling of use, non-stickiness, skin familiarity and penetration It was also confirmed that an oil-in-water emulsified composition that was extremely excellent was obtained.

Test example 3
Using the liposome composition obtained in Test Example 2, a creamy oil-in-water emulsion composition having the composition shown in Table 5 was prepared. The production method and composition uses a liposomal composition instead of hydrogenated soybean lecithin, and an egg yolk ethanol extract (egg yolk oil) [“yolk lecithin PL-30S” manufactured by QP Corporation; (Iodine value 73, phosphatidylcholine content 29.6% by weight) is contained in 30% by weight. The same as in Example 2 except that addition timing is the same as the liposome composition.

  The obtained oil-in-water emulsion composition was evaluated in the same manner as in Test Example 2 with respect to the feeling of use, lack of stickiness, skin familiarity, and penetration.

  The results obtained are shown in Table 5. From this result, the addition of egg yolk ethanol extract together with liposomes formed with hydrogenated soybean lecithin and egg yolk ethanol extract (egg yolk lecithin) further enhances skin familiarity and penetration, and the feeling of use is extremely good. It was revealed that an oil-in-water emulsion composition can be obtained.

Formulation Examples 1-34
Liposome compositions were prepared according to the formulations described in Tables 6-9. Specifically, a liposome composition was prepared in the same manner as in Test Example 2. Further, in the same manner as in Test Example 3, an oil-in-water emulsion composition containing the obtained liposome composition was prepared. The obtained oil-in-water emulsion composition was excellent in terms of a feeling of use, lack of stickiness, skin familiarity, and penetration.

Claims (8)

  (A) polyglycerin fatty acid ester, (B) anionic surfactant, (C-1) stearyl alcohol, (C-2) behenyl alcohol, and (D) lecithin, and (A) polyglycerin fatty acid ester The content is 0.5 to 1.2% by weight, the content of (B) anionic surfactant is 0.1 to 0.8% by weight, and the content of (C-1) stearyl alcohol is (C -2) An oil-in-water emulsified composition characterized in that it is more than behenyl alcohol.   The oil-in-water emulsion composition according to claim 1, wherein 1.5 to 5 parts by weight of the (C-1) stearyl alcohol is contained with respect to 1 part by weight of the (C-2) behenyl alcohol.   The oil-in-water emulsion composition according to claim 1 or 2, comprising at least hydrogenated lecithin as the (D) lecithin.   The oil-in-water emulsion composition according to any one of claims 1 to 3, wherein the (D) lecithin is contained in a liposome form containing hydrogenated lecithin and natural lecithin.   The oil-in-water emulsion composition according to claim 4, wherein 20 to 130 parts by weight of the hydrogenated lecithin is contained with respect to 1 part by weight of the natural lecithin.   The oil-in-water emulsion composition according to claim 4 or 5, wherein a lower alcohol extract of egg yolk is used as the natural lecithin.   Furthermore, the oil-in-water emulsion composition in any one of Claims 4-6 containing the lower alcohol extract of an egg yolk separately from the said liposomal form (D) lecithin.   The oil-in-water emulsion composition according to any one of claims 1 to 7, which is a creamy cosmetic.