JP5641665B2 - External preparation for skin and method for producing the same - Google Patents

Description

  The present invention relates to a skin external preparation, and more particularly to a skin external preparation that is excellent in the effect of improving the skin condition and does not excessively suppress sebum secretion. The present invention also relates to a method for producing such an external preparation for skin.

Various active ingredients are blended in an external preparation for skin such as cosmetics according to the purpose of use. In particular, external factors such as sun exposure and dry environment are known to promote the photoaging of the skin, thereby reducing the original function of the skin and causing the generation of wrinkles, tarmi, spots, etc. and the dryness of the skin. Therefore, a skin external preparation having an effect of suppressing these phenomena has been demanded.
In response to such demands, proteins such as collagen, elastin, keratin, etc. derived from natural products and their hydrolysates, animal and plant extracts, animal and vegetable oils, natural polysaccharides, fruit acids, polymer compounds, etc. It has been. In recent years, methods for improving photo-aging and functional deterioration of the skin by blending vitamin A and its derivatives have been developed.
However, the development of an active ingredient that exhibits a more excellent effect has not been achieved yet, and the development of an external preparation for skin that exhibits the intended effect has not been achieved. In addition, when vitamin A or a derivative thereof is added, since these components suppress sebum secretion, there is a drawback of accelerating the drying of the skin, which is effective in solving the above problems without decreasing sebum secretion. Development of ingredients is desired.

Problems to be solved by the invention

  An object of the present invention is to provide a skin external preparation that suppresses photoaging and functional deterioration of the skin due to external factors such as exposure to sunlight and a dry environment without suppressing sebum secretion.

Means for solving the problem

In order to achieve the above object, the present inventors have conducted intensive studies, and as a result, there is no problem in safety by blending vitamin A and / or a derivative thereof with an apple seed extract. Has been found to solve the problem, and the present invention has been completed.
Accordingly, the present invention relates to a skin external preparation characterized by containing vitamin A and / or a derivative thereof and an apple seed extract.
One embodiment of the present invention is to use a base prepared by a high pressure homogenizer. Therefore, this invention relates to said skin external preparation containing the base prepared with the high pressure homogenizer. The present invention also relates to the above-mentioned external preparation for skin in the form of a solubilized preparation or an emulsion preparation.
The present invention is further directed to a method for producing an external preparation for skin, which comprises preparing a mixture containing a base and an apple seed extract with a high-pressure homogenizer, adding vitamin A and / or a derivative thereof to the mixture, and mixing the mixture. It has been.

  Examples of skin external preparations used in the present specification include emulsions, creams, lotions, cosmetic oils, packs, cleansings, cleansing agents (facial cleansing foams, body shampoos, etc.), ointments, cosmetic liquids, gels, and hair restorers. Can be mentioned.

Examples of vitamin A and / or a derivative thereof used in the present invention include vitamin A (also known as retinol); vitamin A fatty acid esters such as retinol acetate and retinol palmitate; retinoic acid and the like. Or in combination of two or more. Vitamin A and / or its derivatives are preferably all trans or 13-cis, and may be a mixture thereof. Of these, vitamin A fatty acid esters are preferably used. Among them, retinol palmitate, which is relatively stable and safe, is particularly suitable. Vitamin A and its derivatives can be appropriately processed as necessary, and examples thereof include microspheres having a particle diameter of 10 μm to 1 mm and those encapsulated in microcapsules. These can use a commercial item.
The amount of vitamin A and / or its derivative blended in the external preparation for skin of the present invention is not particularly limited, but considering the effects and influences on the skin, it is 0.00005-2 mass based on the total mass of the external preparation for skin. % Is suitable, and preferably 0.0005 to 0.5 mass%.

  The apple seed extract used in the present invention is extracted from the seeds of apple Malus domestica Borkhausen (Rosaceae) (or Pyrus Malus) using an extraction solvent. Although the preparation method is not particularly limited, the extraction is performed under conditions of low temperature, room temperature, and heating using various solvents. Examples of the extraction solvent include water; lower monohydric alcohols such as methanol and ethanol; polyhydric alcohols such as 1,3-butylene glycol, propylene glycol and glycerin; and organic solvents such as acetone, ether, ethyl acetate, and n-hexane. One kind or a mixture of two or more kinds selected can be used.

  As a method for extracting the apple seed extract, the washed raw material is crushed as it is or appropriately, mixed with an extraction solvent, and then immersed and extracted. During extraction, concentration under reduced pressure, centrifugation, enzyme treatment, filtration, or the like may be performed as necessary. As the apple seed extract used in the present invention, the extract obtained as described above can be used as it is depending on the extraction solvent, or can be used in an appropriately concentrated form, or the extraction solvent. The residue after distilling off (referred to as pure extract) may be used. Moreover, what diluted the extract pure part obtained as mentioned above with the hydrophilic solvent or lipophilic solvent including water can also be used as an apple seed extract. The shape of the apple seed extract may be powdery, liquid or semi-solid, and either oily or aqueous may be used. You may use a commercial item as an apple seed extract. As a specific example of a commercial product, the pure extract as described above is called an apple seed extract diluted and dissolved in a cosmetic solvent such as ethanol, 1,3-butylene glycol, purified water or a mixture thereof, and hexyldecanol. For example, Ederline (manufactured by SEPORGA) is known.

An example of an operation for obtaining an apple seed extract is as follows: the apple is squeezed, and the residue is recovered and washed. After separating the seeds, they are pulverized and extracted with an ethanol solvent. The solvent is then distilled off (evaporated) and the residue is dissolved in a cosmetic solvent. This is filtered, heated at 65 ° C. for 12 hours, and cooled to room temperature to obtain an apple seed extract.
The amount of the apple seed extract to be blended in the external preparation for skin of the present invention is 0.0001 to 1.5 as a residue (extract extract) excluding the extraction solvent, based on the total mass of the external preparation for skin. A mass% range is suitable. Within such a range, a synergistic effect with vitamin A and its derivatives can be obtained without problems. When the extract obtained by diluting and dissolving the pure extract with an appropriate solvent is added to the external preparation for skin, the amount is generally 0.01% to 30% by mass based on the total mass of the external preparation for skin. It exists in a range, More preferably, it exists in the range of 0.05%-10 mass%.

In the external preparation for skin of the present invention, in addition to the essential components described above, other than the above-mentioned essential ingredients, other than the above-mentioned essential components, are used as long as the effects of the present invention are not impaired. Ingredients such as fats and oils, waxes, hydrocarbons, fatty acids, higher alcohols, esters, surfactants, animal and plant extracts, moisturizers, alcohols, thickeners, drugs, UV absorbers, UV scattering agents Pigments, colorants, preservatives, antioxidants, flavoring agents, chelating agents, and the like can be blended as necessary.
The preparation method of the external preparation for skin of the present invention is not particularly limited, and can be prepared according to a usual method.

The external preparation for skin of the present invention uses a base prepared using a high-pressure homogenizer (high-pressure emulsifier), particularly in the case of solubilized preparations such as lotions and emulsion preparations such as creams and emulsions. Thus, a unique sensory characteristic, specifically, a smooth and excellent application feeling can be obtained, and the effect of the external preparation for skin of the present invention can be further enhanced.
When using a high-pressure homogenizer, as a base component, at least selected from a solubilizer or emulsifier, for example, a nonionic surfactant, lecithin (phospholipid) obtained from soybean or egg yolk, and a derivative thereof (mainly lysozyme). 1 type; at least one polyhydric alcohol selected from glycerin, 1,3-butanediol, propylene glycol, dipropylene glycol, polyethylene glycol, isoprene glycol, 1,2-pentanediol, etc .; ester oil, silicon and its At least one oil selected from derivatives, animal and vegetable oils, higher fatty acids, higher alcohols, mineral oils, and the like; and water are used.

  The solubilizer or emulsifier used for the preparation is not particularly limited. For example, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyglycerin fatty acid ester, polyethylene glycol fatty acid ester, polyoxyethylene sorbit Fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene polyoxypropylene block polymer, polyoxyethylene polyoxypropylene alkyl ether, sucrose fatty acid ester, maltitol fatty acid ester, alkyl glucoside, egg yolk lecithin, soybean lecithin, egg yolk lysolecithin, soybean Examples include lysolecithin, hydroxylated soybean lecithin, and hydrogenated products thereof. As these solubilizers or emulsifiers, one or a combination of two or more of these can be used.

  In the case of a solubilized preparation, a base is obtained by treating a premixed solution obtained by uniformly mixing a solubilizer, a polyhydric alcohol, water and an oil component with a high-pressure homogenizer. In the case of an emulsified preparation, an emulsifier, a polyhydric alcohol and an oil are uniformly mixed to obtain an oil phase, and a pre-emulsion prepared by adding water to this is further treated with a high-pressure homogenizer to obtain a base. Preparation of a premixed liquid or a pre-emulsion can be implemented by a conventional method using a normal pressure type homogenizer. In addition, in these preparations, it can heat or heat-process suitably as needed.

  When preparing a base using a high-pressure homogenizer, the mass ratio of solubilizer or emulsifier, polyhydric alcohol, oil and water is generally based on the total amount of the premixed solution / preliminary emulsion. Solubilizing agent: 15 to 45% by mass, polyhydric alcohol: 10 to 50% by mass, oil content: 1 to 15% by mass, and water to 10 to 50% by mass. : 0.2-4% by mass, polyhydric alcohol: 2-30% by mass, oil: 5-40% by mass, water: 20-80% by mass. The base obtained by the high-pressure homogenizer can be used as it is as the base for the external preparation for skin of the present invention, or the base is mixed with an appropriate base as the base for the external preparation for skin of the present invention. Also good. Apple seed extract and optionally other additives may be added during the preparation of the above premix or pre-emulsion or when using a high pressure homogenizer, as long as the components do not decompose by heat. .

Specific examples of high-pressure homogenizers used include Gorin homogenizer APV (manufactured by Runny), Nanomizer (manufactured by Nanomizer), Microfluidizer (manufactured by Microfluidics, Mizuho Kogyo Co., Ltd.), Ultimateizer (manufactured by Sugino Machine) Among them, a microfluidizer is preferable. The microfluidizer is disclosed in U.S. Pat. No. 4,533,254, and is a continuous ultra-high pressure homogenizer that can regulate pressure from ²⁰⁰ to 3000 kgf / cm ² depending on the model. In the case of using a high-pressure homogenizer, the pressure can be appropriately selected from the range in which the pressure can be adjusted, for example, 1000 to 1500 kgf / cm ² , and the number of passes can be appropriately selected from 1 to 5 times.

Since a mixture prepared using a high-pressure homogenizer has a relatively high temperature immediately after preparation, it is preferable to add vitamin A and / or a derivative thereof after cooling sufficiently to room temperature or below, and further necessary. If it exists, other components are added and mixed uniformly to obtain the external preparation for skin of the present invention. Apple seed extract may be added along with vitamin A and / or its derivatives.
The external preparation for skin of the present invention can be used in a usual manner according to the form.

  Next, the present invention will be specifically described with reference to examples and comparative examples. In addition, this invention is not limited by these.

Example 1 and Comparative Examples 1 to 4

  Creams of Example 1 and Comparative Examples 1 to 4 were prepared with the composition shown in Table 1 (unit: mass%, total amount: 100 mass%).

^*1：配合量は抽出物純分としての量である。
^*2：リンゴ：Malus domestica Borkhause (Rosaceae)の果実（生）からの1,3-ブチレングリコール溶液による抽出物。配合量は抽出物純分としての量である。

^{* 1} : The blending amount is the amount of pure extract.
^{* 2} : Apple: Extract from Malus domestica Borkhause (Rosaceae) fruit (raw) with 1,3-butylene glycol solution. A compounding quantity is the quantity as an extract pure part.

Cream Production Method Dissolve (11) and (12) in a part of component (15), and add (13) dissolved in part of (15). Next, a solution obtained by dissolving (10) and (14) is added to the mixture of (6) and (7) to make it uniform, and (1) to (5), (8), (9) and the remaining (15) ) Was added and stirred uniformly to obtain the creams of Example 1 and Comparative Examples 1 to 4.

<Usage test 1: degree of improvement of skin>
The creams of Example 1 and Comparative Examples 1 to 4 were used by 10 healthy female panels (28 to 45 years). Use the cream of Example 1 on the right face and the cream of Comparative Example 1 twice a day (morning and evening) on the left face, and after use for 1 month, the effect after use compared to before use Evaluation was made by self-reporting of 10 people (Test 1). Thereafter, the left face was sequentially changed to the creams of Comparative Examples 2, 3, and 4, and the same test was performed (Tests (2), (3), and (4)).
The evaluation items were a) an effect of imparting firmness to the skin, b) an effect of improving wrinkles, and c) a moisturizing effect on the skin, and evaluation was performed according to the following criteria.
A: It was quite effective. B: Somewhat effective.
C: There was no change. D: It got worse.
Table 2 summarizes the number of each judgment A to D.

[Table 2] Skin improvement

表２の結果から明らかなように、本発明に従った実施例１のクリームは、比較例１〜４のものと比較して、優れた肌状態の改善効果を有していることが判る。The average evaluation of the above tests (1) to (4) of the cream of Example 1 is as follows.

As is apparent from the results in Table 2, it can be seen that the cream of Example 1 according to the present invention has an excellent skin condition improving effect as compared with those of Comparative Examples 1 to 4.

<Use test 2: amount of sebum>
The creams of Example 1 and Comparative Examples 1 to 4 were used by 10 healthy female panels (28 to 45 years). For use, apply the cream of Example 1 and Comparative Examples 1-4 to the forehead part twice a day (morning and evening), measure the amount of sebum in the forehead part after use for one month continuously. The amount of sebum in the forehead before use was compared.
For the measurement of the amount of sebum, the forehead, which is the test site, was gently wiped with a 70% ethanol aqueous solution before measurement, and the amount of sebum (μg / cm ² ) of the forehead was measured with an oil meter (Sebumeter SM810) 30 minutes later. . The results are summarized in Tables 3-4.

使用後の下段の数値は、使用前との差を示す。[Table 3] Sebum amount in the forehead (μg / cm ² )

The lower number after use shows the difference from before use.

使用後の下段の数値は、使用前との差を示す。[Table 4] Sebum amount in the forehead (μg / cm ² )

The lower number after use shows the difference from before use.

  As is apparent from the results of Tables 3 and 4, it can be seen that the cream of Example 1 according to the present invention suppresses the decrease in the amount of sebum due to the vitamin A derivative.

The skin external preparations of Examples 2 to 11 are shown below. Each composition is 100% by mass in total.
Example 2
Toner lotion mass%
(1) Retinoic acid 0.005
(2) Apple seed extract (aqueous, 3% pure extract) 3.0
(3) Polyoxyethylene (40) hydrogenated castor oil 0.2
(4) Polyoxyethylene (20) Polyoxypropylene (4) 0.1
Cetyl ether
(5) Polyethylene glycol 1000 2.0
(6) 1,2-pentanediol 1.0
(7) Propylene glycol 1.5
(8) Ethanol 3.0
(9) Methylparaben 0.1
(10) Natural vitamin E 0.05
(11) Hydroxypropyl methylcellulose 0.12
(12) Citric acid (10% aqueous solution) 0.1
(13) Sodium citrate (10% aqueous solution) 0.6
(14) Remaining purified water <Production method>
(11) is added to (14) and dissolved, and the mixture of (3) to (10) and (12) and (13) are added thereto. Finally, (1) and (2) were added and mixed, and this was filtered to obtain a lotion. This skin lotion was excellent in improving the skin condition without suppressing sebum secretion.

Example 3
Milk mass%
(1) Retinol palmitate 0.5
(Microsphere product: average particle size 35μm)
(2) Apple seed extract (oily, 3% pure extract) 10.0
(3) Tri (capryl / capric acid) glycerin 1.0
(4) Octyldodecyl myristate 1.0
(5) Squalane 0.5
(6) Glycerin 3.5
(7) Dipropylene glycol 1.5
(8) Methylparaben 0.1
(9) Ethylparaben 0.05
(10) Propylparaben 0.05
(11) Phenoxyethanol 0.3
(12) Tocopherol acetate 0.1
(13) Hydrogenated soybean phospholipid 0.4
(14) Carboxyvinyl polymer (1% aqueous solution) 10.0
(15) L-arginine (10% aqueous solution) 0.7
(16) Purified water balance <Production method>
(2) to (13) are mixed at 80 ° C, and (16) heated to 80 ° C is gradually added thereto. This solution was homogenized at 5000 rpm for 3 minutes using a homomixer, followed by high-pressure emulsification with a microfluidizer (1200 kgf / cm ² , two passes). After the high-pressure emulsification treatment was added to (14) and made uniform, (15) was added and mixed, cooled to about 30 ° C., and finally (1) was added to obtain an emulsion. This emulsion was excellent in use feeling and excellent in improving the skin condition without suppressing sebum secretion.

Example 4
Cream mass%
(1) Retinol palmitate 0.5
(2) Apple seed extract (oily, 3% pure extract) 5.0
(3) Glyceryl tri-2-ethylhexanoate 2.0
(4) Cetyl 2-ethylhexanoate 2.0
(5) Vaseline 0.5
(6) Liquid paraffin 7.0
(7) Lipophilic glyceryl monostearate 0.5
(8) Polyglycerol fatty acid ester 3.5
(9) 1,3-butylene glycol 6.0
(10) Methylparaben 0.2
(11) Phenoxyethanol 0.5
(12) Tocopherol acetate 0.1
(13) Stearic acid 0.3
(14) Carboxyvinyl polymer (1% aqueous solution) 30.0
(15) Potassium hydroxide (10% aqueous solution) 1.0
(16) Purified water balance <Production method>
(2) to (13) are mixed at 80 ° C, and (16) heated to 80 ° C is gradually added thereto. Further, after adding (14) heated to 80 ° C., add (15), mix, and cool to around 30 ° C. Finally (1) was added to obtain a cream. This cream was excellent in improving the skin condition without suppressing sebum secretion.

Example 5
Makeup Gel Mass%
(1) Retinol acetate 0.0005
(2) Apple seed extract (oiliness, 3% pure extract) 0.01
(3) Dimethicone (10CS) 3.0
(4) Polyoxyethylene / methylpolysiloxane copolymer 1.5
(5) 1,3-butylene glycol 2.5
(6) Glycerin 2.5
(7) Sorbit solution 1.5
(8) Ethanol 2.0
(9) Methylparaben 0.2
(10) Tocopherol acetate 0.05
(11) Xanthan gum 0.12
(12) Carboxyvinyl polymer 0.4
(13) Sodium hydroxide (10% aqueous solution) 1.0
(14) Remaining purified water <Production method>
(3) to (5) are mixed, and a solution obtained by dissolving (12) in (14) is added thereto, and (13) is further added to make uniform. Next, a mixture of (6) to (11) was added, and finally (1) and (2) were added to obtain a cosmetic gel. This cosmetic gel was excellent in improving the skin condition without suppressing sebum secretion.

Example 6
Essence mass%
(1) Retinol palmitate 2.0
(2) Apple seed extract (aqueous, 3% pure extract) 3.0
(3) Olive oil 0.2
(4) Polyoxyethylene (60) hydrogenated castor oil 2.0
(5) Maltitol 0.5
(6) Glycerin 2.5
(7) Trehalose 1.5
(8) Ethanol 3.0
(9) Methylparaben 0.2
(10) Magnesium phosphate ascorbyl 0.5
(11) Xanthan gum (1% aqueous solution) 5.0
(12) Hydroxyethyl cellulose (1% aqueous solution) 15.0
(13) Trimethylglycine 1.0
(14) Remaining purified water <Production method>
(3) to (9) are mixed, and (14) is added thereto to make it uniform, and then (10) to (13) are further added to make it uniform. Next, (1) and (2) were added to obtain a serum. The cosmetic liquid of the present invention was excellent in the effect of improving the skin condition without suppressing sebum secretion.

Example 7
Facial cleansing foam
(1) Retinol acetate 0.00005
(2) Apple seed extract (oiliness, 3% pure extract) 0.05
(3) Sodium acylglutamate 22.0
(4) sodium tetradecene sulfonate 5.0
(5) 1,3-butylene glycol 10.0
(6) Glycerin 5.0
(7) Lauric acid diethanolamide 3.0
(8) Polyethylene glycol 1500 5.0
(9) Methylparaben 0.2
(10) Tocopherol acetate 0.05
(11) Polyethylene glycol monostearate 4.0
(12) Dipotassium glycyrrhizinate 0.1
(13) Allantoin 0.1
(14) Remaining purified water <Production method>
(3) to (13) are mixed at 80 ° C., and (14) heated to 80 ° C. is gradually added thereto and mixed. After cooling to about 30 ° C. and adding (1) and (2) to make it uniform, a defoaming treatment was performed to obtain a face-washing foam. This facial cleansing foam was excellent in improving the skin condition without suppressing sebum secretion.

Example 8
Pack mass%
(1) Retinol acetate 0.05
(2) Apple seed extract (oiliness, 3% pure extract) 0.5
(3) Polyvinyl alcohol 8.0
(4) Polyethylene glycol 1500 1.5
(5) Propylene glycol 5.5
(6) Methylparaben 0.1
(7) Polyoxyethylene (60) hydrogenated castor oil 0.5
(8) Tocopherol acetate 0.05
(9) Ethanol 8.5
(10) edetate disodium 0.05
(11) Perfume 0.03
(12) Purified water balance <Production method>
(4) to (8) are mixed, and a solution obtained by heating and dissolving (3) in (12) is added thereto, and (9) and (11) are further added to make uniform. Next, (1) and (2) were added to obtain a pack. Said pack was excellent in the improvement effect of skin condition, without suppressing sebum secretion.

Example 9
Cleansing Mass%
(1) Retinol palmitate 0.0005
(2) Apple seed extract (oiliness, 3% pure extract) 0.8
(3) Polyoxyethylene (20) cetyl ether 3.5
(4) Polyoxyethylene (7) Palm oil fatty acid glyceryl 1.5
(5) 1,3-butylene glycol 5.0
(6) Glycerin 3.0
(7) Phenoxyethanol 0.5
(8) Ethanol 2.0
(9) Methylparaben 0.2
(10) Dibutylhydroxytoluene 0.05
(11) Xanthan gum (1% aqueous solution) 10.0
(12) Carboxyvinyl polymer (1% aqueous solution) 50.0
(13) Potassium hydroxide (10% aqueous solution) 1.5
(14) Remaining purified water <Production method>
(3) to (10) are mixed, and (12) and (13) are added to make this uniform. Further, (11) and (14) were added to make uniform, and finally (1) and (2) were added to obtain cleansing. This cleansing was excellent in improving the skin condition without suppressing sebum secretion.

Example 10
Hair restorer mass%
(1) Retinol palmitate 0.05
(2) Apple seed extract (oiliness, 3% pure extract) 0.1
(3) Egg yolk lysophosphatidylcholine 0.5
(4) β-glycyrrhetinic acid 0.1
(5) D-pantothenyl alcohol 0.5
(6) Glycerin 2.5
(7) 1,3-butylene glycol 1.5
(8) Ethanol 35.0
(9) Methylparaben 0.2
(10) Tocopherol acetate 0.1
(11) Polyoxyethylene (40) hydrogenated castor oil 0.1
(12) Purified water balance <Production method>
(1) to (4), (6) and (7) are mixed, and (12) is gradually added thereto. This liquid was appropriately high-pressure emulsified, and (9) to (11) dissolved in (8) was added to the high-pressure emulsified liquid to obtain a uniform hair growth agent. This hair-growth agent was excellent in use feeling and excellent in improving the scalp state without suppressing sebum secretion.

Example 11
Cosmetic oil mass%
(1) Retinol palmitate 0.1
(2) Apple seed extract (oiliness, 3% pure extract) 30.0
(3) Natural vitamin E 0.1
(4) Macadamia nut oil 1.0
(5) Batyl alcohol 0.3
(6) Octyldodecanol remaining <Production>
A cosmetic oil was obtained by uniformly mixing (1) to (6). This cosmetic oil was excellent in use feeling and excellent in improving the skin condition without suppressing sebum secretion.

Effect of the invention

  The external preparation for skin of the present invention contains vitamin A and / or a derivative thereof, suppresses an excessive decrease in the amount of sebum, and reduces the original function of the skin caused by external factors such as sun exposure and dry environment. It is a skin external preparation that suppresses the generation of wrinkles, tarmi, spots, etc. and synergistically improves skin dryness.

Claims (5)

Vitamin A and / or vitamin A fatty acid ester and apple seed extract , wherein the apple seed extract is water, methanol, ethanol, 1,3-butylene glycol, propylene glycol, glycerin and two or more of these skin external agent characterized in der Rukoto those extracted using by the solvent selected from the group consisting of a mixture as the extraction solvent.
Contains 0.00005-2 mass% of vitamin A and / or vitamin A fatty acid ester based on the total mass of the external preparation for skin, and 0.0001-1.5 mass% of apple seed extract as a pure extract. The external preparation for skin according to claim 1.
The external preparation for skin according to claim 1 or 2, which is in the form of a solubilized preparation or an emulsified preparation.
The skin external preparation of any one of Claims 1-3 containing the base prepared with the high voltage | pressure homogenizer.
The mixture was prepared containing bases and apple seed extract by high pressure homogenizer, seen including admixing with the addition of vitamin A and / or vitamin A fatty acid ester to the mixture, the apple seed extract is water, methanol, A method for producing an external preparation for skin, which is extracted using a solvent selected from the group consisting of ethanol, 1,3-butylene glycol, propylene glycol, glycerin and a mixture of two or more thereof as an extraction solvent .