JP2003212750A - Gel composition and emulsified composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a gel composition having a high self tissue body-forming ability, excellent stability with time and high emulsifiability of an oil, and an emulsified composition capable of efficiently forming fine emulsified particles stable with time with physically weak stirring force by adding water to the gel composition. <P>SOLUTION: This gel composition contains a compound represented by general formula 1 (wherein, R<SP>1</SP>is an amino acid; R<SP>2</SP>is an alkyl; R<SP>3</SP>is hydrogen) and/or its salt and a polyglyerol fatty acid ester as essential ingredients. Furthermore, various ingredients of cosmetics used for a skin care preparation, quasi- drugs, medicines, etc., or ingredients used for foods can be contained. <P>COPYRIGHT: (C)2003,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a gel composition and an emulsion composition containing a compound represented by the general formula 1 and / or a salt thereof and a polyglycerol fatty acid ester. More specifically, the present invention relates to a gel composition and an emulsified composition having a high oil emulsifying ability and excellent temporal stability by containing a compound represented by the general formula 1 and / or a salt thereof and a polyglycerin fatty acid ester.

[0002]

2. Description of the Related Art In recent years, studies have been made on the use of natural or derived surface-active substances as emulsifiers in terms of human safety. In such a situation, Bacillus sub
The surface-active substance represented by the general formula 1 secreted and produced in the process of fermentation by a microorganism represented by tilis and the like is also expected as a highly safe natural emulsifier, and various emulsification methods have been studied.

[0003]

[Problems to be Solved by the Invention] In such a situation,
The function required for external preparations for skin such as cosmetics is a system utilizing the surfactant of natural products, that is, the so-called biosurfactant, to obtain a gel composition and an emulsion composition thereof, and further, the gel composition thereof. By adding water to the mixture, it is possible to efficiently form stable and fine emulsified particles over time with a physically weak stirring force.

[0004]

Means for Solving the Problems The inventors of the present invention have made extensive studies in view of the above-mentioned circumstances, and as a result, by containing a compound represented by the general formula 1 and / or a salt thereof and a polyglycerin fatty acid ester, self-organization The inventors have completed the invention of a gel composition and an emulsified composition having high forming ability, excellent stability over time, and high oil emulsifying ability.

That is, the gel composition and the emulsified composition of the present invention contain the compound represented by the general formula 1 and / or a salt thereof and polyglycerin fatty acid ester, have a high self-organizing ability and are stable over time. It is a composition having excellent properties.

The structure of the present invention will be described in detail below.

The substance of the general formula 1 used in the present invention is Ba
It is a so-called biosurfactant, which is secreted and produced in the process of fermentation by a microorganism represented by Cillus subtilis.

Specifically, R ¹ is an amino acid, and most of them are selected from L-leucine, L-isoleucine, L-valine and the like. R ² is C ₈ -C ₂₂ alkyl having a carbon chain,
It may be linear, branched, cyclic, and saturated or unsaturated. As R ³ , hydrogen or a salt can be used, and an alkali metal salt such as sodium salt or potassium salt is used.
Further, a mixed system thereof may be used.

In the compound represented by the general formula 1 used in the present invention, preferably, R ¹ is L-leucine, R ² is the general formula 2, and R ³ is sodium.

The content of the compound represented by the general formula 1 is not particularly limited, but it is preferably 0.1 to 10% by weight, and if less than 0.1% by weight, stability with time may be poor. However, it is possible to contain more than 10% by weight, but it is not economical.

The polyglycerin fatty acid ester used in the present invention is not particularly limited, but preferably, the polyglycerin part has a degree of polymerization of 4 or more, and the fatty acid part is a C _{8 to} C ₂₂ carbon chain, Examples thereof include saturated, unsaturated, straight-chain, branched, and the like, and one or more selected from these may be contained in combination.

The content of the polyglycerin fatty acid ester is not particularly limited, but it is preferably 0.1 to 5% by weight, and if it is less than 0.1% by weight, the stability with time may be poor. It is unfavorable to use if the content is more than wt%.

The gelation method used in the present invention can be adjusted by a generally known method, but preferably, the compound represented by the general formula 1 and / or a salt thereof, a polyglycerin fatty acid ester and glycerin are mixed (X Part), then X
This is a method of gradually adding the oil phase while stirring the parts. Preferred is a method of heating part X and the oil phase to 50 to 80 ° C.

Specific examples of the tetraglycerin fatty acid ester include tetraglyceryl monolaurate and tetraglyceryl monooleate, and the hexaglycerin fatty acid ester includes hexaglyceryl monomyristate, hexaglyceryl diisostearate, hexaglyceryl sesquiisostearate and hexaglyceryl dilaurate. As the decaglycerin fatty acid ester, decaglyceryl monolaurate, decaglyceryl dimyristate, decaglyceryl distearate, decaglyceryl triisostearate, decaglyceryl monooleate and the like can be mentioned.

In addition to the above-mentioned essential components, the composition of the present invention may contain various components such as cosmetics, quasi drugs, pharmaceuticals and the like which are commonly used in external preparations for skin, and components which are used in foods. For example, oily ingredients, lipids, humectants, thickeners, medicinal ingredients, bactericidal / preservatives, pigments, powders, pH adjusters, sequestering agents, ultraviolet absorbers, antioxidants, plasticizers, fragrances, amino acids, Sweeteners, colorants and the like can be appropriately added. Further, other surfactants can be blended in the role of assisting gel forming ability and emulsifying ability.

Specific examples of the oily component include fats and oils, waxes, hydrocarbons, fatty acids, higher alcohols, esters, silicone oils, fluorine oils and the like. Examples of the humectant include polyhydric alcohol, mucopolysaccharide, amino acid, saccharide, biopolymer and the like. As the thickener, for example, water-soluble polymer, clay mineral, super absorbent polymer,
Examples thereof include oil-soluble gelling agents. Examples of the medicinal component include various vitamins and their derivatives, allantoin, glycyrrhizic acid and its derivatives, various animal and plant extracts, and the like. Further, as the emulsifier, for example, polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, nonionic surfactant such as polyoxyethylene hydrogenated castor oil, sodium stearoyl lactylate. And the like, amphoteric surfactants such as soybean phospholipids, and cationic surfactants such as alkyltrimethylammonium chloride.

The gel composition and the emulsified composition of the present invention can be produced by known methods and can be used in any field such as cosmetics, quasi drugs, external medicines, foods, etc. It can be arbitrarily selected according to the purpose and can be in the form of cream, emulsion, lotion, gel, ointment, pack, stick and the like.

[0018]

The gel composition and emulsion composition of the present invention contain the compound represented by the general formula 1 and / or a salt thereof and a polyglycerin fatty acid ester,
The oil has a high emulsifying ability and excellent stability over time.

In order to demonstrate these effects, Examples 1 to 1
13 and Comparative Examples 1 to 8 were prepared and evaluated.

Prior to the examples, a gelling method, an emulsifying method and a method for evaluating stability with time used in the present invention will be described.

(Gelification method) After thoroughly stirring the parts A shown in Tables 1 and 2 at room temperature, the oil phase (part B) which was heated to 60 ° C. and also heated to 60 ° C. was stirred to the parts A. While gradually adding. Then, it cooled to room temperature and obtained the gel composition.

(Emulsification method) After thoroughly stirring the parts A shown in Tables 1 and 2 at room temperature, the oil phase (part B) which was heated to 60 ° C. and also heated to 60 ° C. was stirred to the parts A. Add gradually.
Then, the aqueous phase (part C) heated to 70 ° C. was added, and the mixture was cooled to room temperature with stirring to obtain an emulsified composition.

(Evaluation of temporal stability of gel composition) 50 ° C.
The state after storage for 2 weeks was visually observed, and the temporal stability was evaluated according to the following criteria. ◎: No change compared to immediately after gelation ○: White turbidity or remarkable change in viscosity compared to immediately after gelation △: Oil bleeding out ×: Gel collapsed and clear separation is observed

(Evaluation of temporal stability of emulsion composition) 50 ° C.
After 2 weeks of storage, the state was visually observed and observed with an optical microscope, and the temporal stability was evaluated according to the following criteria. ⊚: Both appearance and emulsified particles are the same as immediately after emulsification, and the emulsified particles are 2 μm or less. ◯: No change in appearance is observed, but some emulsified particles are 2 μm or more. Δ: No separation is observed, but the emulsified particles are large and non-uniform. ×: Separation is observed

[0025]

[Table 1]

As shown in Table 1, the compound represented by the general formula 1 (R ¹ is L-leucine, R ² is the general formula 2, R ³ is sodium) (hereinafter referred to as sample 1) and polyglycerin fatty acid ester The temporal stability of the gel compositions of Examples 1 to 5 using decaglyceryl monooleate as a result was a better result than Comparative Examples 1 to 4.

[0027]

[Table 2]

As shown in Table 2, the temporal stability of the emulsion compositions of Examples 6 to 10 using sample 1 and decaglyceryl monooleate as the polyglycerin fatty acid ester was better than those of Comparative Examples 5 to 8. Met.

As described above, according to the present invention, by containing the compound represented by the general formula 1 and / or its salt and the polyglycerin fatty acid ester, the emulsifying ability of the oil is high and the stability over time is excellent. It is possible to provide a gel composition and an emulsified composition.

[0030]

EXAMPLES The present invention will now be described with reference to examples, but the present invention is not limited thereto.

[0031]   Example 11 Moisturizing gel cream     A sample 1 2.0% by weight         Hexaglyceryl diisostearate 1.0         Glycerin 5.0     B Squalane 40.0         Octyldodecyl myristate 50.0         Stearyl alcohol 2.0         Cetanol 1.0         Vitamin E acetate moderate amount         Fragrance suitable amount

After heating the parts A and B to 60 ° C.,
Parts are gradually added to part A with stirring to obtain a gel composition. Then cool to room temperature. The obtained gel composition was a good moisturizing gel cream excellent in stability over time.

[0033] Example 12 Cleansing Gel A sample 2 5.0 wt% ^{(R 1} of Formula 1 is L- valine, ^{R 2} is alkyl of saturated branched _C 14 _{~ 16,} ^{R 3} is hydrogen) monooleate deca Glyceryl 1.5 Glycerin 5.0 B Liquid paraffin 50.0 Isononyl isononanoate 20.0 Nylon powder 1.0 Perfume Suitable amount C 1,3-butylene glycol 5.0 Carboxyvinyl polymer 1.0 Sodium hydroxide 0.5 Xanthan gum 0.2 Preservative Suitable amount Purified water Residual

After heating parts A and B to 60 ° C.,
Parts are gradually added to part A with stirring to obtain a gel composition. After that, part C heated to 70 ° C. is added and the mixture is emulsified with stirring and cooled to room temperature. The resulting cleansing composition was a good emulsion composition having a particle size of 2 μm or less, and had good stability over time. Also, the feeling of use was refreshing and there was no stickiness.

Example 13 Suspension type lotion A Sample 3 1.0% by weight (R ^{1 of the} general formula ¹ is L-leucine, R ² is a C ₁₈ branched alkyl, R ³ is potassium) Tetraglyceryl monolaurate 0 .3 Hexaglyceryl sesquiisostearate 0.3 Glycerin 1.0 B Sunflower oil 5.0 Jojoba oil 5.0 Vitamin A palmitate 0.1 Fragrance suitable amount C preservative suitable amount sequestering agent appropriate amount pH adjuster appropriate amount purified water residual

After heating the parts A and B to 60 ° C.,
Parts are gradually added to part A with stirring to obtain a gel composition. After that, part C heated to 70 ° C. is added and the mixture is emulsified with stirring and cooled to room temperature. The obtained suspension-type lotion was a good emulsion composition having a particle size of 2 μm or less, and had good stability over time. Also, the feeling of use was refreshing and there was no stickiness.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Jiro Kitahara             2-7 Torimicho, Nishi-ku, Nagoya-shi, Aichi Japan             Nard Cosmetics Co., Ltd. (72) Inventor Satoru Nakata             2-7 Torimicho, Nishi-ku, Nagoya-shi, Aichi Japan             Nard Cosmetics Co., Ltd. F term (reference) 4C083 AA122 AB032 AC022 AC072                       AC122 AC342 AC352 AC421                       AC422 AD072 AD092 AD152                       AD352 AD411 AD412 AD622                       AD662 BB51 CC04 CC05                       CC22 DD22 DD27 DD31 DD41                       EE01 EE06 EE12                 4G065 AA01 AB02Y AB05Y AB11Y                       AB12Y AB18Y AB38Y BB06                       BB08 CA02 CA14 DA02 EA02

Claims (8)

[Claims] 1. A gel composition comprising a compound represented by the general formula 1 (R ¹ is an amino acid, R ² is alkyl, R ³ is hydrogen) and / or a salt thereof and a polyglycerin fatty acid ester. [Chemical 1] 2. R ^{1 in the} general formula 1 is an amino acid selected from L-leucine, L-isoleucine and L-valine, and R 1
The gel composition according to claim 1, wherein ² is C _{8 to} C ₂₂ alkyl, and R ³ is hydrogen or an alkali metal. 3. The gel composition according to claim 1, wherein R ^{1 in the} general formula 1 is L-leucine, R ² is the general formula 2, and R ³ is sodium. [Chemical 2] 4. The polyglycerin part of the polyglycerin fatty acid ester has an average degree of polymerization of 4 or more, and the fatty acid part is C ₈
Claim characterized in that it is a -C ₂₂ 1 through claim 3
The gel composition according to 1. 5. The gel composition according to claim 1, wherein the compound represented by the general formula 1 and / or its salt, polyglycerin fatty acid ester and glycerin are mixed and the oil phase is gradually added while stirring. A gelling method characterized by obtaining a product. 6. The content of the compound represented by the general formula 1 and / or its salt is 0.1 to 10% by weight, and the content of polyglycerin fatty acid ester is 0.1 to 5% by weight. The gel composition according to any one of claims 1 to 5, which is characterized. 7. An emulsified composition obtained by adding water to the gel composition according to claim 1 to emulsify it. 8. The gel composition and / or the emulsified composition according to claim 1, which is used as a skin external preparation.