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Publication number
JP2009545600A5
JP2009545600A5 JP2009522882A JP2009522882A JP2009545600A5 JP 2009545600 A5 JP2009545600 A5 JP 2009545600A5 JP 2009522882 A JP2009522882 A JP 2009522882A JP 2009522882 A JP2009522882 A JP 2009522882A JP 2009545600 A5 JP2009545600 A5 JP 2009545600A5
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JP
Japan
Prior art keywords
pharmaceutical composition
isoindol
dione
piperidine
dihydro
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Application number
JP2009522882A
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English (en)
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JP5465005B2 (ja
JP2009545600A (ja
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Priority claimed from PCT/US2007/017343 external-priority patent/WO2008019065A1/en
Publication of JP2009545600A publication Critical patent/JP2009545600A/ja
Publication of JP2009545600A5 publication Critical patent/JP2009545600A5/ja
Application granted granted Critical
Publication of JP5465005B2 publication Critical patent/JP5465005B2/ja
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Claims (16)

  1. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンを含む、ヒトのマントル細胞リンパ腫を治療するための医薬組成物。
  2. 前記マントル細胞リンパ腫が、再発性、難治性、又は従来の療法に抵抗性である、請求項１記載の医薬組成物。
  3. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、約1〜約50mg/日の量で投与されるように用いられることを特徴とする、請求項１又は２記載の医薬組成物。
  4. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、約10、15、20又は25mg/日の量で投与されるように用いられることを特徴とする、請求項３記載の医薬組成物。
  5. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、約25mg/日の量で投与されるように用いられることを特徴とする、請求項４記載の医薬組成物。
  6. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、鏡像異性的に純粋である、請求項３記載の医薬組成物。
  7. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、S鏡像異性体である、請求項６記載の医薬組成物。
  8. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、R鏡像異性体である、請求項６記載の医薬組成物。
  9. 経口投与用に製剤されている、請求項３記載の医薬組成物。
  10. カプセル又は錠剤の形態である、請求項９記載の医薬組成物。
  11. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、28日のサイクルにおいて、21日間投与され、続いて7日間休薬されるように用いられることを特徴とする、請求項３記載の医薬組成物。
  12. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンが、28日のサイクルにおいて、約25mg/日の量で21日間投与され、続いて7日間休薬されるように用いられることを特徴とする、請求項１１記載の医薬組成物。
  13. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンとともに又は別々に、リツキシマブが毎週静脈内注射によって375mg/m2の量で投与されるように用いられることを特徴とする、請求項１２記載の医薬組成物。
  14. 3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンを含む、マントル細胞リンパ腫を治療するための医薬組成物であって、3-(4-アミノ-1-オキソ-1,3-ジヒドロ-イソインドール-2-イル)-ピペリジン-2,6-ジオンとともに又は別々に、第2の活性薬剤が投与されるように用いられることを特徴とする、前記医薬組成物。
  15. 前記第2の活性薬剤が、抗体、造血成長因子、サイトカイン、抗癌剤、抗生物質、cox-2阻害剤、免疫調節剤、免疫抑制剤、コルチコステロイド又は薬理活性変異体、或いはそれらの誘導体である、請求項１４記載の医薬組成物。
  16. 前記第2の活性薬剤が、リツキシマブである、請求項１４記載の医薬組成物。
JP2009522882A 2006-08-03 2007-08-02 マントル細胞リンパ腫治療のための３−（４−アミノ−１−オキソ−１，３−ジヒドロ−イソインドール−２−イル）−ピペリジン−２，６−ジオンの使用 Active JP5465005B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US83575206P 2006-08-03 2006-08-03
US60/835,752 2006-08-03
PCT/US2007/017343 WO2008019065A1 (en) 2006-08-03 2007-08-02 Use of 3- (4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment of mantle cell lymphomas

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013168932A Division JP2013256514A (ja) 2006-08-03 2013-08-15 マントル細胞リンパ腫治療のための３−（４−アミノ−１−オキソ−１，３−ジヒドロ−イソインドール−２−イル）−ピペリジン−２，６−ジオンの使用

Publications (3)

Publication Number Publication Date
JP2009545600A JP2009545600A (ja) 2009-12-24
JP2009545600A5 true JP2009545600A5 (ja) 2010-09-02
JP5465005B2 JP5465005B2 (ja) 2014-04-09

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Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009522882A Active JP5465005B2 (ja) 2006-08-03 2007-08-02 マントル細胞リンパ腫治療のための３−（４−アミノ−１−オキソ−１，３−ジヒドロ−イソインドール−２−イル）−ピペリジン−２，６−ジオンの使用
JP2013168932A Withdrawn JP2013256514A (ja) 2006-08-03 2013-08-15 マントル細胞リンパ腫治療のための３−（４−アミノ−１−オキソ−１，３−ジヒドロ−イソインドール−２−イル）−ピペリジン−２，６−ジオンの使用

Family Applications After (1)

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JP2013168932A Withdrawn JP2013256514A (ja) 2006-08-03 2013-08-15 マントル細胞リンパ腫治療のための３−（４−アミノ−１−オキソ−１，３−ジヒドロ−イソインドール−２−イル）−ピペリジン−２，６−ジオンの使用

Country Status (26)

Country Link
US (7) US20080038263A1 (ja)
EP (1) EP2046331B1 (ja)
JP (2) JP5465005B2 (ja)
KR (2) KR20140082859A (ja)
CN (2) CN102908346A (ja)
AR (1) AR062265A1 (ja)
AT (1) ATE486601T1 (ja)
AU (1) AU2007282027B2 (ja)
CA (2) CA2659774C (ja)
CL (1) CL2007002218A1 (ja)
CY (1) CY1110989T1 (ja)
DE (1) DE602007010303D1 (ja)
DK (1) DK2046331T3 (ja)
ES (1) ES2351069T3 (ja)
HR (1) HRP20100664T1 (ja)
IL (1) IL196885A (ja)
ME (1) ME01937B (ja)
MX (1) MX2009001268A (ja)
PE (1) PE20081311A1 (ja)
PL (1) PL2046331T3 (ja)
PT (1) PT2046331E (ja)
RS (1) RS51567B (ja)
RU (1) RU2446804C2 (ja)
SI (1) SI2046331T1 (ja)
TW (1) TWI430797B (ja)
WO (1) WO2008019065A1 (ja)

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