JP2002047165A - Cosmetic for sunburn prevention - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a means for further raising an effect of an ultraviolet light protection agent and preventing pigmentation and an inflammation. SOLUTION: This cosmetic is obtained by adding an ultraviolet light protection agent and an α-MSH inhibitor such as an essence of Sophora root, etc., to a skin care preparation.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to cosmetics, and more particularly, to cosmetics useful for preventing sunburn.

[0002]

2. Description of the Related Art Prevention of sunburn in the sense of including sunburn (sunlight burns) is a very important issue in skin care. For this purpose, cosmetics containing an ultraviolet protective agent have been developed and marketed. Have been. Examples of such ultraviolet protective agents include masking metal oxides such as titanium dioxide and zinc oxide, cinnamic acid and its esters, p-dimethylaminobenzoic acid and its esters, slisobenzone and its salts, acetylacetone and oxybenzone. So-called ultraviolet absorbers are known. However,
Even if treated with cosmetics containing such UV protective agents,
It is difficult to prevent the occurrence of inflammation caused by ultraviolet rays and pigmentation caused by this inflammation. It is said that in the case of UV protection by metal oxide, the generation of radicals from the metal oxide caused by UV irradiation may cause inflammation. It is said that no ultraviolet light can cause inflammation. It is also known that pigmentation and the like are likely to occur at the site of inflammation.

On the other hand, α-melanotropin (α-MSH)
Is already known to be a substance involved in inflammation and pigment biosynthesis, but no substance that inhibits this action has been known yet. It was not known at all to combine them into cosmetics. In addition, Arnica Montana
L), extracts of herbal base plants such as Hamamelis virginiana and legume Clara
It is already known as a raw material for cosmetics, but it was not known at all that these substances have an α-MSH inhibitory action.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances, and it is an object of the present invention to provide a means for further enhancing the effect of an ultraviolet protective agent and preventing pigmentation and inflammation. And

[0005]

In view of such a situation, the present inventors have conducted intensive research efforts to find a means for further enhancing the effect of an ultraviolet protective agent and for preventing the occurrence of pigmentation and inflammation. Arnica (Arnica Montana L), Hamamarisu (Hama
melis virginiana) and leguminous Clara
It has been found that such a technique is possible by combining an α-MSH inhibitor consisting of an extract such as the above and an ultraviolet protective agent, and has completed the invention. That is, the present invention relates to the following technology. (1) A cosmetic comprising an α-MSH inhibitor and an ultraviolet protective agent. (2) The cosmetic according to (1), wherein the α-MSH inhibitor is an extract of leguminous Clara (Bitterfruit; Kuddin). (3) The cosmetic according to (1) or (2), wherein the extract is an alcohol extract. (4) the ultraviolet protective agent is one or more selected from titanium dioxide, zinc oxide, cinnamic acid and its ester, p-dimethylaminobenzoic acid and its ester, slisobenzone and its salt, acetylacetone and oxybenzone; The cosmetic according to any one of (1) to (3). (5) for preventing sunburn, (1)-
(4) The cosmetic according to any one of the above. (6) 1) Legume Clara extract and 2) Titanium dioxide,
Zinc oxide, cinnamic acid and its ester, p-dimethylaminobenzoic acid and its ester, slisobenzone and its salt, acetylacetone and one or more selected from oxybenzone, characterized by containing
Cosmetics. (7) The cosmetic according to (6), which is used for preventing sunburn. Hereinafter, the present invention will be described in more detail focusing on embodiments.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION (1) α-MSH inhibitor which is an essential component of the cosmetic of the present invention The cosmetic of the present invention is characterized by containing an α-MSH inhibitor as an essential component. The term “α-MSH inhibitor” as used in the present invention means a group of substances that inhibit the production of α-melanotropin which is deeply involved in melanin production. B-16 cells), screening can be performed by examining the amount of cyclic AMP produced as an index. That is, the cells were cultured in a 96-well plate at 10% FBS in MEM (Eagle's minimal medium) at 5% CO 2 and 95% at 37 ° C. in a 96-well plate.
Culture overnight at 60 μl / well and add α-MS
H (1 × 10 −7 M) and various concentrations of the test substance were added.
Using a Biolake Cellular Communication Assay cAMP Enzyme Immunoassay System (code RPN225) manufactured by Amersham, Inc.
Α-MSH by measuring as a spectrophotometer of 0 nm
Inhibitory effects can be screened. As substances having such an α-MSH inhibitory action, the present inventors have proposed Arnica (Arnica Montana L), Hamamaris (Hama
melis virginiana) and leguminous Clara
And the like. Of these, Clara is particularly preferred. Here, the extract referred to in the present invention is a plant itself, a processed product obtained by drying, shredding, pulverizing, etc., a plant, an extract obtained by adding a solvent to the plant or its processed product, and extracting, A solvent-removed product obtained by removing the solvent, an extract or a generic name such as a purified product obtained by column chromatography or liquid-liquid extraction of the solvent-removed product, and among them, the extract is particularly preferable.
Among them, a polar solvent extract extracted with a polar solvent such as water or alcohol is particularly preferred. The extraction may be performed according to a usual method. For example, one extraction is performed on a plant or a processed product thereof.
Add 10 to 10 times the amount of solvent, immerse for several days at room temperature, or for several hours at a temperature near the boiling point, and then remove insolubles by filtration, if necessary, concentrate under reduced pressure or freeze The solvent may be removed by drying or the like. The α-MSH inhibitor of the present invention thus obtained inhibits α-MSH, prevents the occurrence of inflammation due to radicals and ultraviolet rays that could not be completely absorbed, and also prevents the production of melanin, When used together with a protective agent, it is possible to prevent adverse effects on the living body due to ultraviolet rays and to enhance the action of the ultraviolet protective agent. The content of the α-MSH inhibitor in the cosmetic of the present invention is preferably 0.01 to 10% by weight, and more preferably 0.05 to 5% by weight. This is because if the amount is too small, the effect may not be exhibited, and if the amount is too large, the effect reaches a plateau and the degree of freedom of prescription may be impaired. Further, the α-MSH inhibitor of the present invention has another medicinal effect, and even if it is contained for the purpose of such a medicinal effect, the effect of the present invention is exerted if it is combined with an ultraviolet protective agent in constitution. Therefore, such a case also belongs to the technical scope of the present invention.

(2) Ultraviolet protective agent which is an essential component of the cosmetic of the present invention The cosmetic of the present invention is characterized by containing an ultraviolet protective agent. The term "UV protective agent" as used in the present invention means a general term for components used in cosmetics in order to protect skin or cosmetic compositions, active ingredients and the like from ultraviolet rays, and specifically, surface-treated. Concealable powders such as titanium dioxide and zinc oxide, cinnamic acid and esters thereof, p-dimethylaminobenzoic acid and esters thereof, which may be present or may have other metal atoms or metal oxides present between lattices. Organic ultraviolet absorbers having a large absorption maximum in the ultraviolet, such as slisobenzone, oxybenzone, acetylacetone and derivatives thereof, can be preferably exemplified. Of these, particularly preferred are isooctyl p-dimethylaminobenzoate,
Examples include isooctyl cinnamate, titanium dioxide containing iron oxide and silicic acid anhydride, and surface-treated products thereof. Preferable examples of the surface treatment include a silicic anhydride coating treatment, a dimethylpolysiloxane baking treatment, a hydrogen methylpolysiloxane baking treatment, a silyl coupling treatment, a treatment with a perfluorophosphate, a treatment with a phosphate, and a treatment with a metal soap. . These components may contain only one kind, or may contain two or more kinds in combination. The preferred content of these ultraviolet protective agents in the cosmetic of the present invention is such that the total amount of the opaque powder is 1%.
-30% by weight, and the total amount of organic ultraviolet absorbers is 0.1-15% by weight. This is because if the amount is too small, the effect of preventing sunburn may not be exhibited.If the amount is too large, the effect may reach a plateau, impairing the flexibility of prescription, or causing an undesirable phenomenon such as a whitish finish. is there.

(3) Cosmetic of the present invention The cosmetic of the present invention is characterized by containing the above essential components. As the cosmetic of the present invention, the kind to be applied is not particularly limited as long as it is generally known as a cosmetic, for example, a lotion, an emulsion, a cream, a basic cosmetic such as a pack, Under makeup cosmetics,
Foundation, cheek color, lip color, makeup cosmetics such as lip balm, hair cosmetics such as hair lotion and hair cream, etc.
Among them, basic cosmetics and make-up cosmetics are particularly preferable, and among them, cosmetics which are left applied all day are particularly preferable. As the purpose of use of the cosmetic, a cosmetic for preventing sunburn is particularly preferable in order to fully exert the effects of the present invention.

The cosmetic of the present invention may contain, in addition to the above essential components, optional components usually used in cosmetics. Examples of such optional components include hydrocarbons such as squalane, petrolatum and microcrystalline wax, jojoba oil, carnauba wax, esters such as octyldodecyl oleate, triglycerides such as olive oil, tallow, coconut oil, and stearic acid. Oleic acid, fatty acids such as ritinoleic acid, higher alcohols such as oleyl alcohol, stearyl alcohol, octyldodecanol, polyhydric alcohols such as polyethylene glycol, glycerin and 1,3-butanediol, thickening / gelling agents, oxidation Examples include an inhibitor, an ultraviolet absorber, a coloring agent, a preservative, and a powder. Among these, particularly preferred optional components include glycerin as a humectant,
Examples of the thickener include a carboxyvinyl polymer and / or a salt thereof. The preferred content of glycerin is 1-1.
0% by weight, and more preferably 2 to 5% by weight.
This is because in this amount range, the trouble occurrence suppressing effect can be remarkably obtained. As the carboxyvinyl polymer salt, alkali metal salts and organic amine salts can be preferably exemplified, and potassium salts and sodium salts are particularly preferable in terms of contribution to stability. The carboxyvinyl polymer and its salt are preferably contained in a total amount of 0.1 to 1% by weight from the viewpoint of balance between stability and safety. The cosmetic of the present invention can be produced by treating these optional and essential components according to a conventional method. The thus-obtained cosmetic also has an action of protecting the effects of radicals and the like that are generated secondarily by light irradiation, so that the occurrence of inflammation or pigmentation due to excessive light irradiation can be prevented.

[0010]

EXAMPLES Hereinafter, the present invention will be described in more detail with reference to Examples, but it goes without saying that the present invention is not limited to only these Examples.

Example 1 According to the following formulation, an emulsion for protection against ultraviolet rays, which is a cosmetic of the present invention, was prepared.
That is, the components (a), (b) and (c) are heated to 80 ° C., and (b) is gradually added to (a) while stirring, and further (c) is gradually stirred and neutralized, and then the emulsified particles are homogenized by a homomixer. An emulsion was obtained. Comparative Example 1 in which Clara extract was changed to water and Comparative Example 2 in which Clara extract was replaced with ketoprofen, an anti-inflammatory agent, were also prepared. The effects of these samples were compared in a test using the inner part of a human upper arm (number of cases: 5). That is, a 2 cm x 2 cm part is placed on the inside of the upper arm
After applying the donated body to each part, ultraviolet rays of 1.2 times the minimum erythema amount (measured in advance using another part) in the state where Comparative Example 1 was applied were applied, and after the irradiation, 24
The degree of inflammation at the time was determined by the Japanese patch test criteria (++: reaction with edema or papule, +: reaction with obvious erythema,
±: reaction with weak erythema,-: no reaction). Further, after 72 hours, pigmentation was measured as a ΔL value using Comparative Example 1 as a control. Table 1 shows the results. From this table, it can be seen that the cosmetics of the present invention prevent inflammation and pigmentation due to ultraviolet irradiation more excellently than ordinary ultraviolet protective agents. This is because the inflammation and pigmentation caused by ultraviolet rays include not only the primary action of ultraviolet rays but also secondary action such as radical generation, and the cosmetic of the present invention has such a secondary action. Is prevented by the extract of Clara, which is an α-MSH inhibitor. In addition, the inflammation was rather increased even when ketoprofen, which is a usual anti-inflammatory agent, was added. This is presumably because the phototoxicity of ketoprofen was caused by light or radicals. I Squalane 10 parts by weight Sorbitan sesquistearate 2 parts by weight Aluminum stearate 5% coated titanium dioxide 5 parts by weight butyl paraben 0.1 parts by weight b 1,3-butanediol 5 parts by weight Xanthan gum 0.1 parts by weight Carboxyvinyl polymer 0 0.2 parts by weight Methyl paraben 0.1 parts by weight Solvent removal from ethanol extract of Clara 1 part by weight Water 45 parts by weight Glycerin 5 parts by weight C Potassium hydroxide 0.1 parts by weight Water 26.4 parts by weight

[0012]

[Table 1]

<Examples 2 to 4> As in Example 1, α of 1
A similar study (but only pigmentation) was performed with the MSH inhibitor replaced. Table 2 shows the results. From this, it was found that the above-mentioned α-MSH inhibitors have the same effect. I Squalane 10 parts by weight Sorbitan sesquistearate 2 parts by weight Aluminum stearate 5% coated titanium dioxide 5 parts by weight butyl paraben 0.1 parts by weight b 1,3-butanediol 5 parts by weight Xanthan gum 0.1 parts by weight Carboxyvinyl polymer 0 0.2 parts by weight Methyl paraben 0.1 parts by weight α-MSH inhibitor * 1 part by weight Water 45 parts by weight Glycerin 5 parts by weight C Potassium hydroxide 0.1 part by weight Water 26.4 parts by weight * Details are shown in Table 2.

[0014]

[Table 2]

<Examples 5 to 8> In the same manner as in Examples 2 to 4, the ultraviolet ray protective agent was changed and the same examination was conducted. Table 3 shows the results. This shows that the same effect was obtained by using other ultraviolet protective agents. I Squalane 10 parts by weight Sorbitan sesquistearate 2 parts by weight UV protective agent ** 5 parts by weight Butyl paraben 0.1 parts by weight b 1,3-butanediol 5 parts by weight Xanthan gum 0.1 parts by weight Carboxyvinyl polymer 0.2 parts by weight Parts 0.1 parts by weight of methylparaben Solvent removal from ethanol extract of Clara 1 part by weight 45 parts by weight of water 5 parts by weight of glycerin 0.1 parts by weight of potassium hydroxide 26.4 parts by weight of water *** Details are shown in Table 3.

[0016]

[Table 3]

Example 9 A foundation was prepared according to the following recipe. That is, the ingredients were kneaded at 90 ° C., packed in a mold, and pressed at 90 ° C. to obtain a foundation. This had an excellent sun protection effect. Hydrogenmethylpolysiloxane baked titanium dioxide 20 parts by weight Hydrogenmethylpolysiloxane baked iron oxide 4 parts by weight Hydrogenmethylpolysiloxane baked talc 20 parts by weight Hydrogenmethylpolysiloxane baked sericite 16 parts by weight Clara root 1,3 -Butanediol extract 3 parts by weight Sorbitan monooleate 1 part by weight p-dimethylaminoisooctyl benzoate 1 part by weight Carnauba wax 5 parts by weight Microcrystalline wax 3 parts by weight Mokuro 3 parts by weight Hydrogenated tallow 4 parts by weight Squalane 20 parts by weight

[0018]

According to the present invention, it is possible to provide a means for further enhancing the effect of the ultraviolet protective agent and preventing the occurrence of pigmentation and inflammation.

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Claims (7)

[Claims] 1. A cosmetic comprising an α-MSH inhibitor and an ultraviolet protective agent. 2. The cosmetic according to claim 1, wherein the α-MSH inhibitor is an extract of leguminous Clara (Diptera; Kujin). 3. The cosmetic according to claim 1, wherein the extract is an alcohol extract. 4. The ultraviolet protective agent is one or more selected from titanium dioxide, zinc oxide, cinnamic acid and its ester, p-dimethylaminobenzoic acid and its ester, slisobenzone and its salt, acetylacetone and oxybenzone. The cosmetic according to any one of claims 1 to 3. 5. It is for sunburn prevention,
The cosmetic according to any one of claims 1 to 4. 6. One selected from 1) an extract of legume Clara and 2) titanium dioxide, zinc oxide, cinnamic acid and its ester, p-dimethylaminobenzoic acid and its ester, slisobenzone and its salt, acetylacetone and oxybenzone. Or two or more cosmetics. 7. It is for sunburn prevention,
The cosmetic according to claim 6.