JP2002020242A - Hair care preparation composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a hair-restoring and growing agent which gives an excellent hair-restoring and growing effect, resists to employment over a long period, and has good safety. SOLUTION: This hair care preparation composition characterized by containing the extracts of one or more plants selected from Acacia catechu Willd., Artemisia dracunculus L., Canarium luzonicum, Curcuma zedoaria Roscoe, Ribes nigrum, Punica granatum, Filipendula ulmaria Maximowicz, F. ulmaia L., Coix lacrima-jobi var. susutama Honda, Ocimum basilicum L., Taraxacum officinale Weber, Acorus gramineus, A. gramineus var pusillus, Aaralia elata Seem, Boswella carterii Birdwood, Angelisa dahurica, Melissa officinalis Linne, Arachis hypogeana, Rosa canina Linne, Rosa eaglanteria L., R. aff. Rubiginosa L., Artemisia absinthium 1., Diospyros kaki, Cynara scolymus, Leucas martinicensis, Bidens pilosa, Eupatorium triplinerve, Brosimum acutifolium, Milania humilifollia, Physalis angulata, and Zizyphusjoazeiro.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external composition for hair containing an extract extracted from a specific plant. Specifically, hair, liquid or gel applied or massaged on the scalp or massaged, or as an external preparation in the form of an aerosol, or shampoo, hair such as a rinsing agent, or blended in a scalp cleaning agent, or a treatment agent, An external hair composition for hair protection, hair quality improvement, hair restoration / hair growth, and white hair prevention / improvement, which are incorporated into cosmetics such as hair tonics and hair styling.

[0002]

2. Description of the Related Art Hair greatly affects the appearance and occupies a very important position in beauty. Possible causes of impaired appearance include thin and thin hair, lack of firmness, loss of luster, and further thinning, depilation, fading, and graying. Although many studies have been conducted on the cause and mechanism of its onset, there are many unclear points about its mechanism.
Even today, there are currently a large number of symptomatic hair external preparations on the market. Among the hair disorders that damage the appearance,
Of greatest interest is hair loss and there are many studies on this.

[0003] Conventionally, hair nourishing cosmetics containing various agents have been known. For example, vitamin E, alloxazine, pyridine N-oxide, adenosine-3 ', 5'-cyclic monophosphate (JP-A-64-56608, JP-A-1-261321, JP-A-2-20)
No. 4406), and extracts such as yokuinin, ginkgo, cashew and the like (Japanese Patent Publication No. 1-134551, JP-A-2-48512, JP-A-2-48514) as a crude drug extract. There is something. There are vitamin Es having a blood circulation improvement effect and assembly extracts, those containing cysteine / methionine as an amino acid as a nutritional supplement for hair, and those containing estradiol / ethynylestradiol, which are female hormones.

[0004]

As described above, extracts of various compounds and crude drugs have been applied to the hair growth and hair growth products provided so far, but their effects are not sufficient in practice. In addition, those having a certain degree of effect have drawbacks such as difficulty in continuous use such as skin irritation. Therefore, it is necessary to search for a hair growth and hair growth promoter that is excellent in hair growth and hair growth effects and has sufficient safety to withstand long-term use, and to develop a hair growth and hair growth material using this as an active ingredient. It was an issue.

[0005]

Means for Solving the Problems In view of such circumstances, the present inventors have conducted intensive studies on natural-derived drugs which are effective in preventing hair loss and hair growth and are excellent in safety. As a result, peguasenyak, estragon , Elemi, Gejutsu, Black Currant, Pomegranate, Spiraea, Juzdama, Sweet Basil, Dandelion, Rosewood, Cod, New Mexico, Juniper, Melissa, Peanut, Rosehip,
Wormwood, City, Alcashofura, Cordon de Frade, Picon, Aiyapana, Muirapiranga,
A plant selected from the group consisting of Scriju, Kamapoo and Joazeiro and an extract thereof were found to have a remarkable hair regeneration effect, and were found to be able to solve the above problems. Even more surprisingly, it was found that the hair became firm and firm. This is thought to be due to the fact that these plant extracts provide nutrition and vitality to hair.

Hereinafter, the present invention will be described in more detail. As described above, the external preparation for hair of the present invention is composed of pegua senjac (Acacia catechu Will).
d. ), Estragon (Artemisia drac)
unculus L. Also known as: Tarragon), Elemi (C
anarium luzonicum, gejutsu (C
urcuma zedoaria Roscoe, blackcurrant (Rives nigrum, alias: blackcurrant, cassis, black currant), pomegranate (Pu)
Nica granatum, Spiraea (Fil)
openula ulmaria maximowi
cz, F.C. ulmia L. ), Juzudama (Coi
x lacrima-jobi var. susuta
ma Honda, Sweet Basil (Ocimum)
basilicum L. Also known as: mebuki, basil,
Basilico, Yellow-crowned Butterfly, Alfavaca), Dandelion dandelion (Taracumum official)
e Weber), Sekisho (Acorus gra)
mineus, A .; gramineus var pu
sillus Another name: Arisugawa Kiseki, Iris,
Iris), cod (Aaralia elat See)
m), New Zealand (Boswella carteri)
iBirdwood, Juniper (Angelisa)
dahurica, also known as yogurusa), Melissa (M
elisa officinalis Linn
e), peanuts (Arachis hypogean)
a), Rosehip (Rosa canina Lin)
ne, Rosa eaglancia L. , R .;
aff. rubiginosa L .; Also known as: Novara, Neubara, Sweet Briar), Wormwood (Art
emisia absinthium L. Also known as: Artemisia, Absinthus, Arsem), City (Dio)
spiros kaki aka: Japanese persimmon; Alkashofura; Akasen Thistle; Cordon de Frade, Leucas
Martinicensis), Picon (Biden)
s pirosa), Aiyapana (Eupatori)
um triplinerve, muirapiranga (B
a plant selected from the group consisting of R. rosimum acutifolium, Suliju (Milania humilifollia), Kamapoo (Physalis angulata), and Joazeiro (Zizyphusjoazeiro), and one or two or more of the extracts selected from the group consisting of an effective hair nourishing ingredient. It has excellent effects on hair growth, preventing and improving gray hair. When obtaining the above plant extracts, flowers, skins, fruits, leaves, roots,
Alternatively, it may be extracted from any part, such as a stem, and at least one of the parts can be extracted with water or a solvent. The extract may be an extract or an extract separated and purified from the extract. In the case of an extract extract, the extract can be obtained by solvent extraction of a dried or crushed plant, and if the extractant is non-toxic for use, the extract may be used as it is. May be used as a diluent, or a concentrated extract, a dry powder by freeze-drying or the like, or a paste prepared. Examples of the solvent used to obtain the plant extract include commonly used organic solvents such as methanol, ethanol, butanol, hexane, heptane, cyclohexane, ethyl acetate, and acetone, and water. The species can be used alone or as a mixture of two or more.
Among these solvents, polar solvents are preferred, and ethanol and water are more preferred. In addition, extraction processing is usually 3 to
It can be carried out by a conventional method at a temperature of about 70 ° C.

[0007] In addition to the solvent extraction, an extract obtained by supercritical extraction in which carbon dioxide gas is brought into a supercritical state can also be used. At this time, hexane, ethanol, or the like can also be used as an extraction aid. Separation and purification of the active ingredient from the extract can be performed by purifying the extract by column chromatography, liquid chromatography, or the like. The amount of the plant or its extract can be appropriately changed depending on the dosage form and the like, but is usually 0.00001 to 20% based on the total amount of the hair cosmetic.
% (% By mass, the same applies hereinafter). Preferably, the content is 0.0001 to 10%. The blending amount is 0.
If it is less than 00001%, the effects of the present invention cannot be exhibited, and the production of some dosage forms becomes difficult. Therefore, it is better not to exceed 20%. The external preparation for hair of the present invention is not particularly limited in its dosage form, for example, creams, lotions, emulsions, ointments, gels, hair tonics, hair liquids, hair rinses, hair shampoos, hair treatments, hair conditioners, aerosols,
It can be formulated into various forms such as air foam and used. Further, the liquid form may be used in combination with a usual propellant, carbon dioxide, oxygen gas, LPG or the like, and filled in a pressure-resistant container.

[0008] In addition to the above essential components, various components can be added to the external preparation for hair of the present invention in accordance with the dosage form and the like. That is, in the present invention, the above-mentioned plant or its extract has other medicinal components, for example, C-AMP and its derivatives which are said to have a gray-hair preventing effect, forskolin, carpronium chloride, pentadecanoic acid glyceride, minoxidil, bFGF When used in combination with a known hair growth promoter such as, for example, the effect can be enhanced. In addition, for example, vitamin E, vitamin E
Nicotinate, cepharanthin, nicotinic acid, nicotinamide, benzyl nicotinate, tincture tincture,
Peripheral vasodilators such as pepper tincture and assembly extract, antioxidants such as coenzyme Q, flavonoids, tannins, polyphenols, cooling agents such as camphor and l-menthol, anti-inflammatory agents such as lysozyme chloride, glycyrrhizin, allantoin, and garlic extract Activators such as carrot extract, carrot extract, gongo extract, rosemary extract, aloe extract, placenta extract, DNA synthesis promoter such as 6-benzylaminopurine, vitamin A, vitamin B
6. Vitamins such as pantothenic acid and biotin; amino acids such as methionine, cysteine, cystine, and tyrosine; fungicides such as salicylic acid, hinokitiol, resorcinol, trichlorocarbanylde, and isopropylmethylphenol; hormones such as ethinyl estradiol and progesterone , Seaweed, aloe, jujube fruit, sesame,
Youtei, wolfberry, mugwort, mustard, rice, mankeishi,
Mannenrou, Kossaiho, Enishida, Gentian, Tanjin, Loofah, Kikyo, Pine, Kujin, Safflower, Barberry, Areca, Eucalyptus, Kagosou, Mokutsu, Gossip, Psycho, Cha, Shini, Wasabi, Joteishi, Dutch Sennici, Gardenia, Usubasaishin , Mint, yoquinin, giraffe, burdock, licorice, hops, chrysanthemum, raccoon, leek, leek, onion, senega,
Extracts and the like from Amacailul, Mannaketake, Jio, Sengoku and the like can be blended.

[0009] In addition, oils, surfactants, moisturizers, lower alcohols, thickeners, antioxidants, chelating agents, sensation imparting agents, pH adjusters, preservatives, fragrances, dyes, etc., are commonly used in hair cosmetics. The raw materials used can be compounded. Specifically, as oil, olive oil, jojoba oil, fats and oils such as hardened oil, whale wax, beeswax, waxes such as lanolin, liquid paraffin, ceresin, hydrocarbons such as squalane,
Fatty acids such as stearic acid and oleic acid; alcohols such as cetanol, stearyl alcohol, lanolin alcohol, and hexyldecanol; and esters such as isopropyl mysterylate and butyl stearate. The oil content is preferably 0.5 to 85% in the hair cosmetic.

Examples of the surfactant include anionic surfactants such as sodium stearate, sodium cetyl sulfonate, polyoxyethylene lauryl ether phosphate, sodium N-acylglutamate, glycerin monostearate, sorbitan monostearate, and the like. Sorbitan sesquioleate, sucrose fatty acid ester, propylene glycol monostearate, polyoxyethylene oleyl ether, polyoxylauryl ether, polyoxyethylene stearyl ether, polyoxyethylene octyl phenyl ether, polyoxyethylene nonyl phenyl ether, monostearic acid Polyethylene glycol, polyoxyethylene sorbitan monopalmitate, polyoxyethylene coconut fatty acid monoethanolamide, polyoxyethylene Polyoxypropylene glycol, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil isostearate, polyoxyethylene hydrogenated castor oil isostearate, pyroglutamic acid isostearate polyoxyethylene castor oil, polyisostearate Examples include nonionic surfactants such as oxyethylene glyceryl, polyoxyethylene glyceryl triisostearate, polyoxyethylene sorbite tetraoleate, and polyoxyethylene lanolinic acid. The surfactant is preferably contained in the hair cosmetic in an amount of 0.1 to 15%. Further, as humectants, glycerin, 1,3-butylene glycol, propylene glycol, dipropylene glycol, ethylene glycol, etc., as lower alcohols, ethanol, isopropanol, etc., as sensation enhancers, l-menthol, nicotine Benzyl acid, etc., as a thickener, polyethylene glycol, carboxymethyl cellulose sodium, etc., as an antioxidant, dibutylhydroxytoluene, butylhydroxyanisole, propyl gallate, etc., as a chelating agent, disodium edetate, Ethanehydroxydiphosphate and the like; pH adjusting agents such as citric acid, sodium citrate, boric acid and sodium hydrogen hydrogen phosphate; and preservatives such as methyl paraoxybenzoate and paraoxybenzoic acid Chill, dehydroacetic acid, salicylic acid, can be exemplified such as benzoic acid, respectively. The optional components are not limited to these.

Although the amount of the external preparation for hair of the present invention can be appropriately changed depending on the dosage form and the like, it is usually preferable to add 0.00001 to 20% by mass based on the total amount of the external preparation. Preferably, the content is 0.0001 to 10% by mass. If the amount is less than 0.00001% by mass, the effects of the present invention cannot be exhibited, and the production of some dosage forms becomes difficult. Therefore, it is preferable that the amount does not exceed 20% by mass.

[0012]

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described specifically with reference to Preparation Examples, Examples, and Formulation Examples of the extract provided by the present invention, but the present invention is not limited to these examples. Absent.

Preparation Example 1 , Cordon de Frade, Picon, Aiyapana, Muirapiranga, Scriju, Kamapoo and Joazeiro were immersed in 700 ml of a 70% ethanol solution, extracted at room temperature for 2 days and night, and then filtered. 300 ml of 70% ethanol is added to the residue, immersed at room temperature for 1 hour, and filtered. This filtrate is combined with the previous filtrate to extract (dry solid content: about 0.1 to 3.0).
0%). In the state of this extract, it can be used as a raw material for certain hair external preparations described below. If necessary, the extraction solvent is distilled off from the extract under reduced pressure to obtain a dry extract. The degree of drying may depend on the application.

Production Example 2 , Cordon de Frade, Picon, Aiyanapana, Muirapiranga, Scriju, Kamapoo, Joazeiro, 100g each, 30% 1,
3-butylene glycol solution or 60% propylene glycol solution, or purified water (about 30 ° C.) 1000 ml
First, it is immersed in 700 ml, extracted at room temperature for two days and nights, and then filtered. The remaining 300 mL is added to the residue, immersed at room temperature for 1 hour, and filtered. This filtrate is combined with the previous filtrate to obtain about 1.0 kg of an extract (dry solid content: 0.1 to 3.0%). Water and / or organic solvent is distilled off from this extract under reduced pressure to obtain extracts (dry products) from various plants using various solvents. Before the extract is completely dried, the distillation of water and / or the organic solvent may be stopped to obtain an extract.

[0015]

[Test Example] [Test Example 1] Measurement of hair growth and hair growth effects (measurement of hair growth effect in mice) Using male C3H mice (7 weeks old), the method of Ogawa et al. (Fragrance Journal, Vo
l. 17, No. 5, P20-29, 1989. The experiment was performed with reference to ()). The back hair of the mouse was removed to a size of about 2 × 4 cm with an electric clipper and an electric shaver. From the next day, samples were applied once a day five times a week for 20 days, the change in the area ratio of the part where hair regeneration started was determined, and the hair regeneration speed was compared. Samples were prepared by dissolving each plant extract obtained in the production example in 70% ethanol to which a surfactant was added so as to have a concentration shown in Table 1 below with stirring to obtain a coated sample. In the test, 70% ethanol was used as a control. For each sample, six mice were used, and the average value of the rate of change was determined. The results of the hair regeneration area on the 20th day are shown in Tables 1 and 2 below as percentages.

[0016]

[Table 1]

[0017]

[Table 2]

As is clear from the above results, pegua senyaku, estragon, elemi, gejutsu, blackcurrant, pomegranate, sycamore, suzudama, sweet basil, dandelion, cedar, cod, cod, neukou, juniper, melissa, peanut, rosehip,
Wormwood, City, Alcashofura, Cordon de Frade, Picon, Aiyapana, Muirapiranga,
A strong hair regeneration effect was observed in the extracts of Scriju, Kamapoo and Joazeiro. In addition, these plant extracts
The effect increased when a hair growth-promoting agent such as a fatty acid derivative (pentadecanoic acid glyceride) having an odd carbon number with a single prime number, tocotrienol, or minoxidil was added.

In the following, pegua senyaku, estragon, elemi, gejutsu, blackcurrant, pomegranate, sycamore, jujudama, sweet basil, dandelion,
Sekisho, Cod, Nyuko, Juniper, Melissa,
Tables 3 and 4 show examples of working formulations of an external preparation for hair containing an extract of peanut, rose hip, wormwood, citrus, alcachofra, cordon de frade, picon, aiyapana, muirapiranga, scriju, kamapoo, and joazeiro. . The following examples all showed an excellent hair regenerating effect and had good safety.

[0020]

[Table 3]

[0021]

[Table 4]

As the dosage form of the external preparation for hair, in addition to the above, hair growth, hair growth shampoo, hair growth, hair growth rinse, hair growth, hair growth tonic formulated in hair care products such as shampoo, rinse, hair tonic and hair cream Hair growth and hair growth hair creams are also possible. These are shown in Tables 5 and 6 in Example 1.
13 to 130, examples 131 and 132 described later.
The prescription was shown.

[0023]

[Table 5]

[0024]

[Table 6]

Example 152 Hair Growth Spray (Undiluted Solution) Monopentadecanoic Acid Glyceride 1.0 Black Currant Extract 1.0 Sorbitan Laurate 0.5 Amphoteric Polymer 0.2 Ethyl Oleate 0.1 Citric Acid 0.3 Sucrose Laurin Acid ester 0.5 perfume appropriate amount L-menthol 0.1 99.5 ethanol total balance 100.0

As the amphoteric polymer, an N-methacryloylethyl-N, N-dimethylammonium / α-N-methylcarboxybetaine / alkyl methacrylate copolymer was used. A hair growth spray was prepared at a ratio of 20 parts of LPG to 80 parts of the stock solution.

Example 153 (hair nourishing hair cream) A (oil phase) Monopentadecanoic acid glyceride 4.0 Sekisho extract 1.0 Ethyl oleate 2.0 Octyldodecyl myristate 1.5 Liquid paraffin 1.0 Mono Polyethylene glycol stearate (40EO) 3.0 Coconut oil fatty acid sorbitan 2.0 Glycerin monostearate 1.0 Cetostearyl alcohol 1.0 Pantothenyl ethyl ether 0.5 Propylparaben 0.1 B (aqueous phase) 1, 3-butylene glycol 2.5 dipropylene glycol 2.5 methyl paraben 0.25 dipotassium glycyrrhizinate 0.2 plancetal liquid 0.2 gentian extract 0.1 purified water Balance C (perfume) appropriate amount total 100.0

The above formulations A and B were each dissolved at 70 ° C., and A was added to B and emulsified uniformly. C was further added while cooling to prepare a hair growth cream.

Examples of the fragrance compositions of Examples 143 to 153 are lavender oil 1.0% (mass% in the fragrance), lemon oil 1,0
%, Orange oil 0.2%, ylang ylang oil 1.0%, benzyl benzoate 10.0%, benzyl acetate 1.0%, celestride 0.5%, eugenol 0.
5%, geranyl nitrile 0.5%, methyl dihydrojasmonate 5.0%, iso-E super 1.5%, limeol 0.5%, linalool 10.0%, linalyl acetate 10.0%, liral 10 0.0%, gamma methylyonone 3.0%, ethylene brassate 1.0%, galaxolide 50% benzyl benzoate solution 1.0%, beta phenyl ethyl alcohol 5.0%, Santalome 0.5%, vetiveryl 1.0% Acetate, 2.0% Acetyl Cedrene, 1.0% Bergamot Oil, 1.0% Geraniol, 0.5% Sage Clary Oil, 0.5% Hexyl Salicylate, 0.1% Jasmine Absolute
%, Hydroxycitronellol 0.1%, rigstral 0.1%, triethyl citrate 0.5%, and the remaining amount of dipropylene glycol. The composition may be changed depending on the product.

If it is necessary to mask the odor of the raw material, the impurities in the raw material, and the odor of foreign substances, a fragrance composition suitable for the masking is used. For example, when masking alcohol-stimulating odor, a large amount of esters such as ethyl acetate and isoamyl acetate are blended. When masking of acetic acid odor when quaternary ammonium acetate, amide alkylguanidine acetate, or the like is blended, linaryl acetate, terpinyl acetate, benzyl acetate, isoamyl acetate, amyl acetate, cis-3-acetate are used. A large amount of acetate-based flavor components such as hexenyl acetate and styryl acetate are blended.

[Test 2] Use effect test The effect of the hair external preparation of the present invention actually used was examined. The test used was a panel of 10 people (25-50 years old) complaining of alopecia and alopecia, and twice daily, morning and night (after washing the hair at night), on the hairline of the scalp and hair. Appropriate amount of hair restorer, hair restorer for 14, 16, 18
Usage tests were performed by applying over a period of six months and six months. The evaluation method is based on the following criteria,
The results are as shown in Table 7, and the numerical values in the table represent the number of people.

"Skin (scalp) disease ameliorating effect" Effective: Extremely large swelling Slightly effective: Slightly swelling ineffective Invalid: No change from before use As a result, hair growth and hair growth effects in humans It was found to be high.

[0033]

[Table 7]

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 U QR A61P 17/14 A61P 17/14 F term (reference) 4C083 AA072 AA111 AA112 AC022 AC072 AC102 AC122 AC302 AC342 AC402 AC422 AC442 AC482 AC642 AD112 AD132 AD202 AD532 CC33 CC37 DD28 EE22 4C088 AB12 AB17 AB26 AB29 AB38 AB41 AB48 AB51 AB59 AB66 AB77 AB80 AB81 BA08 CA05 CA06 CA07 CA08 CA09 CA10 MA63 NA06 NA07 Z92

Claims (1)

[Claims] 1. Peguasenyak, estragon, elemi,
Gajutsu, blackcurrant, pomegranate, pomegranate, sycamore, jujudama, sweet basil, dandelion, sekisho, cod, neukou, juniper, melissa, peanut, rosehip, wormwood, city, alkashofura, cordon de frade, picon, ayapana, mucripirang An external preparation for hair comprising, as an active ingredient, one or more of a plant selected from the group consisting of, kamapoo and joazeiro or an extract thereof.