JP2002145793A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care preparation which can improve the antibacteri al activity of an antibacterial action-having plant extract formulated into the preparation and has a low irritation property against skins. SOLUTION: This skin care preparation is characterized by formulating one or more alcohols selected from dihydric alcohols and one or more of the antibacterial extracts of plants such as rosemary, thyme, Lamium album, Perilla frutescens crispa in Labiatae, Scutellaria baicalensis as an original plant of scutellariae radix, Glycyrrhiza glabra and Sophora angustifolia in Leguminosae, Eriobotrya japonica in Rosaceae, moutan bark and Paeonia lactiflora in Rosaceae, aloe in Liliaceae, Coptis japonica in Ranunculaceae, Phellodendri cortex in Rutaceae, turmeric in Zingiberaceae, Betula tauschii in Betulaceae, Houttuynia cordata in Saururaceae as the original plant of Houttuynia herb, and Cinnamomum camphora in Lauraceae as the original plant of camphor.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin,
More specifically, the present invention relates to an external preparation for skin, in which the antibacterial activity of a plant extract having an antibacterial action incorporated in the external preparation is improved and the skin is less irritating to the skin.

[0002]

BACKGROUND OF THE INVENTION Generally, an antiseptic is incorporated into a skin external preparation for the purpose of ensuring antiseptic and antifungal properties and improving preservability. And as a preservative in a typical skin external preparation, paraoxybenzoic acid ester (commonly called parabens) can be mentioned. These parabens are excellent in safety and effectiveness as preservatives in skin external preparations,
Nevertheless, this does not mean that a very small number of sensitive users may be accompanied by a feeling of irritation during use. In particular, in recent years, there has been a tendency for skin external preparations that are more gentle on the skin to be demanded, and it is very difficult to completely satisfy the recent demand for such skin external preparations only by using these parabens as preservatives. That is the fact. Of course, it is also possible to create an external preparation for the skin that does not contain parabens, but in this case, it is necessary to make full use of complicated means such as a small container and a backless mechanism to ensure antiseptic properties. The tendency of lack of economy, versatility, etc. is remarkable.

[0003] The present invention has been made in view of the above-mentioned conventional circumstances, and shows an effective antibacterial action without deteriorating the antibacterial activity by a base or other compounding components. It is an object of the present invention to provide an external preparation for skin which is excellent in safety and can be made paraben-free by reducing the amount of preservatives and fungicides used.

[0004]

Means for Solving the Problems In order to solve the above-mentioned problems, the present inventors have studied an antiseptic and antifungal system having high stability and low irritation to the skin. As a result, one or more kinds of dihydric alcohols are selected. It has been found that the antibacterial activity is synergistically improved by combining the use of one or two or more plant extracts having an antibacterial action, and the present invention has been accomplished.

[0005] That is, the present invention is a skin external preparation characterized by combining one or more selected from dihydric alcohols with one or more plant extracts having an antibacterial action. .

Further, the present invention is characterized in that a combination of one or more selected from dihydric alcohols and one or more plant extracts having an antibacterial action is blended as an active ingredient for preservatives and fungi. An antiseptic / antifungal agent comprising a combination of one or more selected from dihydric alcohols, and one or more plant extracts having an antibacterial action, and an antibacterial action A method for enhancing the antibacterial activity of a plant extract having an antibacterial action, characterized by adding one or more kinds selected from dihydric alcohols to a plant extract having the following.

Hereinafter, the configuration of the present invention will be described. As the dihydric alcohol to be incorporated into the skin external preparation of the present invention,
Those selected from the group represented by the following general formulas (1) to (4) are preferred.

[0008]

CH ₂ OH—CHOH—R ¹ (1) CH ₂ OH—R ² —CH ₂ OH (2) CH ₃ —CHOH—R ³ —CHOH—CH ₃ (3) CH ₂ OH— CH _(a-2) (R ⁴ ) _a —CHOH—R ⁵ (4)

Wherein R ¹ represents an alkyl group having 2 to 6 carbon atoms, R ² represents a linear or branched alkylene group having 1 to 8 carbon atoms, and R ³ represents an alkylene group having 1 to ³ carbon atoms. R ⁴ and R ⁵ are the same or different, each represents an alkyl group having 1 to 4 carbon atoms, and a represents 0, 1 or 2.)

The amount of these dihydric alcohols greatly depends on the solubility in water, but is generally preferably 0.1 to 15.0% by weight in order to exert the desired antibacterial effect. 0.5 to 10.0% by weight is particularly preferred.

The antimicrobial plant extract used in the present invention includes Lamiaceae rosemary, thyme,
Red croaker, Scutellaria and perilla, which are the plants that are the origins of Cruciferous melon, Legume family Licorice and Clara, Rosaceae loquat, Button family Pinpi and Paeonia, Lily family Aloe, Ranunculaceae spinach, Rutaceae family Oubak,
There are turmeric of the ginger family, birch of the birch family, bud of the herb medicine Zhuyaku, and the camphor tree of the camphor tree.

The method for preparing these plant extracts is not particularly limited. The whole plant may be used for extraction, but flowers, stems, roots,
When a site containing a particularly strong antibacterial component in each plant, such as a seed, a fruit, or a bark, is apparent, it is preferable to select and use that site. Further, the plant may be extracted as it is, or the extraction operation may be performed after processing such as shredding, drying, and pulverization.

As an extraction solvent, in addition to water, methanol,
Ethanol, propanol, isopropanol, butanol, ethylene glycol, propylene glycol,
1,3-butylene glycol, diethylene glycol,
Highly polar organic solvents such as dipropylene glycol, isoprene glycol, hexylene glycol, glycerin, methyl acetate, ethyl acetate, isopropyl acetate, ethyl ether, isopropyl ether, and acetone can be used. One of these may be used alone, or two or more may be used in combination.

The above-mentioned plant extract can be added to cosmetics as it is, or can be blended after a purification operation such as deodorization and decoloration is performed within a range not to lose the antibacterial action. Further, the extraction solvent is evaporated and dried from the extract, and water, ethanol, propylene glycol, 1,3-
It can also be added after re-dissolving in a solvent such as butylene glycol or glycerin. The amount of the plant extract is 0.0
001-5.0% by weight (as a dry solid component) is appropriate, and more preferably 0.001-1.0% by weight.

In this way, by combining one or more selected from dihydric alcohols and one or more selected from antibacterial plant extracts, surprisingly, the antiseptic property is improved. There is provided a skin external preparation that has been significantly improved synergistically.

In the present invention, it is not necessary to add another preservative to the external preparation for skin, but it is possible to add another preservative within a range not to impair the intended effect of the present invention. It is. However, from the viewpoint of safety and exhibiting the features of the present invention, it is preferable that the skin external preparation contains no other preservative.

The external preparation for skin of the present invention comprises other components having an anti-inflammatory effect, for example, glycyrrhizic acid and salts thereof,
By blending glycyrrhetinic acid and its salts, tranexamic acid, etc., it is also possible to provide a hypoallergenic skin external preparation having an acne-preventing effect by the above-mentioned antibacterial and anti-inflammatory effects.

The external preparation for skin of the present invention may be a moisturizing agent, an ultraviolet ray protective agent, vitamins, an animal or plant extract, a whitening agent or the like depending on the intended properties of the external skin preparation within a range not to impair the intended effect. Agents, vasodilators, astringents, cooling agents, hormonal agents, and the like that can be roughly blended with the external preparation for skin can be blended.

The external preparation for skin of the present invention can be widely applied to cosmetics, pharmaceuticals, quasi-drugs and the like applied to the outer skin, and its dosage form can be aqueous, solubilized, emulsified, etc. A wide range of dosage forms can be adopted, such as a system, an oil-liquid system, a gel system, a paste system, an ointment system, an aerosol system, a water-oil two-layer system, and a water-oil-powder three-layer system. That is, if it is a basic cosmetic, it will be a face wash,
It can be widely applied to various forms such as lotions, milks, creams, gels, essences (packs, masks) and the like. Further, if it is a makeup cosmetic, it can be widely applied to various forms such as foundation, mascara, nail enamel, lipstick and the like. Further, if it is a hair cosmetic, it can be widely applied to various forms such as shampoos, rinses, and hair nourishes. As long as it is a drug or a quasi drug, it can be widely applied to various ointments and the like.
It should be noted that the dosage form and form of the external preparation for skin of the present invention are not limited to these dosage forms and forms.

In the skin external preparation of the present invention, generally known base components are widely blended according to the desired dosage form and form as long as the desired effects of the present invention are not impaired by the blending. be able to. That is, liquid fats, solid fats, waxes, hydrocarbon oils, higher fatty acids, higher alcohols, synthetic ester oils, silicones, various surfactants, sequestering agents, water-soluble polymers, thickeners, humectants In addition, various powder components, coloring agents, fragrances, water, and the like can be appropriately added to the external preparation for skin of the present invention as needed.

[0021]

Next, the present invention will be described specifically with reference to examples. It goes without saying that the present invention is not limited to only the following examples. All compounding amounts are% by weight, and all compounding amounts of the plant extract are in terms of dry solids. Prior to disclosing the examples, a use test and a test for judging preservative power will be described first.

(1) Use Test The prepared sample was actually used by a specialized panel of 10 people, and a sensory test was conducted. The evaluation results are shown in the following display. ◎: Eight or more of the ten responded that they were good. ：: 6 or more and less than 8 out of 10 responded as good. B: 4 or more and less than 6 out of 10 responded as good. ×: Less than 4 out of 10 responded as good.

(2) Test for judging antiseptic activity A 30 ml sample was inoculated with a bacterial solution, and a change in the number of bacteria was examined by a smear method. The inoculated bacteria were evaluated for their antiseptic activity based on changes in the number of bacteria up to two weeks after the use of mold, yeast, and bacteria, and the obtained results were classified into the following four-grade criteria.
In addition, among the following classifications, those with ◎ or ○ were judged to be acceptable. A: The effect is immediately recognized. ：: The effect is gradually recognized. Δ: Almost no effect was observed. X: No effect is observed at all.

Examples 1 to 7 and Comparative Examples 1 to 5 Lotions were prepared according to the following formulation in accordance with the conventional methods, and the above-mentioned use test and antiseptic judgment test were carried out. The results are shown in Tables 1 and 2. (Prescription) Ethyl alcohol 3.0% by weight Glycerin 1.0 POE (60) hydrogenated castor oil 0.3 Citric acid 0.03 Trisodium citrate 0.07 Dipropylene glycol 5.0 Sodium metaphosphate 0.01 Purified water Residual polyhydric alcohol described in Tables 1 and 2 Plant extract described in Tables 1 and 2

[0025]

[Table 1]

[0026]

[Table 2]

* 1: 50% ethanol extract * 2: 50% butylene glycol extract

As shown in Table 1, in the examples, the proportion of those who satisfied the usability was large, and the antiseptic property was ensured. On the other hand, as shown in Table 2, in the comparative example, only the dihydric alcohol or the combination of the plant extract alone was insufficient in the preservative power.

From these results, by combining one or more selected from dihydric alcohols with one or more plant extracts having an antibacterial action,
It was revealed that a skin external preparation having synergistically improved preservative power and good usability was provided.

The skin preparation for external use of the present invention having various formulations will be described below. All the examples have excellent usability while maintaining excellent antiseptic power. The method for producing the external preparation for skin in these examples was in accordance with the method generally used as the method for producing the external preparation for skin in each embodiment.

Example 8 Astringent lotion 1,2-butanediol 2.0% by weight Denatured alcohol 15.0 Glycerin 5.0 1,3-butylene glycol 3.0 POE (50) Oleyl ether 0.5 3-methoxy -3-Methyl-1-butanol 2.0 Sodium metaphosphate 0.01 Citric acid 0.03 Sodium citrate 0.07 Phenoxyethanol 0.3 50% ethanol extract of urethane 0.005 Perfume Appropriate amount Purified water Remainder

Example 9 Cleansing foam Stearic acid 8.0% by weight Palmitic acid 6.0 Myristic acid 4.0 Caustic potash 5.2 Glyceryl monostearate 2.0 Beeswax 1.5 1,10-decanediol 0.1 2,6-heptanediol 0.1 PEG 1500 5.0 glycerin 10.0 50% propylene glycol extract of aloe 0.01 purified water balance

Example 10 Emulsion 1.5% by weight of cetanol Stearyl alcohol 1.8 Vaseline 2.0 Dimethyl polysiloxane 1.5 Squalane 3.0 Isopropyl myristate 2.5 Glyceryl monostearate 1.8 POE (5) Glyceryl Monostearate 1.8 POE (20) cetyl ether 1.5 Carboxyvinyl polymer 0.2 Caustic potash 0.25 Glycerin 6.0 Dipropylene glycol 5.0 1,4-Butanediol 2.0 Loquat 50% butylene glycol Extract 0.001 50% ethanol extract of rosemary 0.001 Trisodium edetate 0.01 Perfume qs Phenoxyethanol 0.3 Purified water Remainder

Example 11 Moisturizing Gel Modified Alcohol 10.0% by Weight Propylene Glycol 5.0 Glycerin 10.0 Alkyl-Modified Carboxyvinyl Polymer 0.1 Carboxyvinyl Polymer 0.2 Dimethylpolysiloxane 2.0 Caustic Potassium 0.1 1, 2-pentanediol 2.0 2,2,4-trimethyl-1,3-pentanediol 0.3 sodium metaphosphate 0.01 dipropylene glycol extract of oak 0.02 propylene glycol extract of Clara 0.01 perfume Appropriate amount of purified water balance

Example 12 Moisturizing Cream Stearyl Alcohol 6.0% by Weight Stearic Acid 2.0 Palm Hardened Oil 4.0 Squalane 9.0 Octyldodecanol 10.0 Polyoxyethylene (25EO) Cetyl Alcohol Ether 0 Glyceryl monostearate 2.0 1,3-butylene glycol 6.0 Diethylene glycol monoethyl ether 4.0 Trisodium edetate 0.01 Glycerin extract of buttonpig 0.02 Hexylene glycol extract of lycopodium 0.005 2-butyl-2-ethyl-1,3-propanediol 1.0 1,7-heptanediol 0.5 purified water balance

Example 13 Anti-Acne Essence Dipropylene Glycol 5.0% by Weight Denatured Alcohol 5.0 Glycerin 2.0 1,3-butylene Glycol 7.0 Carboxyvinyl Polymer 0.4 Squalane 5.0 Dipotassium Glycyrrhizinate 0.0 05 Tranexamic acid 1.0 Trimethylglycine 1.0 Butylene glycol extract of perilla 0.5 Ethanol 50% ethanol extract 0.5 Sengyu 70% butylene glycol extract 0.5 Bompi 50% ethanol extract 1 d-Camphor 0.01 Phenoxyethanol 0.3 Potassium hydroxide qs Perfume qs Purified water balance

[0037]

As described above, according to the present invention,
An external preparation for skin having sufficient antibacterial activity and low skin irritation without using a conventional antiseptic and fungicide is provided.

Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat II (reference) A61K 35/78 A61K 35/78 KV 7/00 7/00 K CMNR 7/48 7/48 9/08 9/08 47/10 47/10 A61P 17/00 A61P 17/00 101 101 17/10 17/10 17/16 17/16 (72) Inventor Yoko Katogi 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama, Kanagawa Prefecture F-term (reference) in Shiseido Research Center (Shin-Yokohama) 4C076 AA12 BB31 CC18 DD30 DD34 DD37 DD38 DD39 DD51 DD70 EE09 EE53 FF56 4C083 AA111 AA112 AA122 AB032 AB282 AC012 AC022 AC072 AC092 AC102 AC111 AC112 AC121 AC122AC AC AC532 AC622 AC712 AD042 AD092 AD152 AD532 CC04 CC05 CC23 DD08 DD41 EE12 EE13 4C088 AB12 AB25 AB32 AB33 AB38 AB47 AB51 AB59 AB60 AB62 AB81 AB85 BA08 MA07 MA63 NA05 NA06 ZA89

Claims (7)

[Claims] 1. An external preparation for skin characterized by combining one or more selected from dihydric alcohols with one or more plant extracts having an antibacterial action. 2. A skin comprising a combination of one or more selected from dihydric alcohols and one or more plant extracts having an antibacterial action as an active ingredient for preservatives and fungi. External preparation. 3. The external preparation for skin according to claim 1, which is substantially free of other preservatives and fungicides. 4. The dihydric alcohol has the following general formula (1) to (4)
The external preparation for skin according to claim 1 or 2, wherein the external preparation is one or more selected from the group represented by: CH ₂ OH—CHOH—R ¹ (1) CH ₂ OH—R ² —CH ₂ OH (2) CH ₃ —CHOH—R ³ —CHOH—CH ₃ (3) CH ₂ OH— CH _(a-2) (R ⁴ ) _a -CHOH-R ⁵ (4) (wherein, R ¹ represents an alkyl group having 2 to 6 carbon atoms, and R ² represents a straight chain having 1 to 8 carbon atoms or Represents a branched alkylene group,
R ³ represents an alkylene group having 1 to 3 carbon atoms, R ⁴ and R
⁵ is the same or different and each represents an alkyl group having 1 to 4 carbon atoms, and a represents 0, 1 or 2. ) 5. One or more plant extracts having an antibacterial activity are derived from rosemary, thyme, lycopodium, perilla in the Labiatae family, or Scarabaeaceae, which is a plant derived from the herbal medicine Ogon, licorice and Clara, and rose in the legume family. Loquat,
Papilionidae and peonies in the button family, Aloe in the lily family,
An extract of a plant selected from the buttercup family, the citrus family oak, the ginger family turmeric, the birch family, birch, the herbaceous medicinal herb, pterodactylaceae, and the camphor origin plant, camphoraceae. The external preparation for skin according to claim 1 or 2, wherein 6. An antiseptic / antifungal agent comprising a combination of one or more selected from dihydric alcohols and one or more plant extracts having an antibacterial action. 7. A method for enhancing the antibacterial activity of a plant extract having an antibacterial activity, wherein one or more selected from dihydric alcohols are added to the plant extract having an antibacterial activity.