JP2002332240A - Hair grower composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a highly safe hair grower composition having good hair growing effect and giving no unfavorable irritancy on the scalp. SOLUTION: This hair grower composition is prepared by including preferably 0.005-15 wt.%, on a solid basis, of laminaria angusta in the genus Laminaria belonging to Phaeophyta.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a hair restorative composition, and more particularly, to a hair restorative composition having excellent hair restoring action and not giving undesired irritation to the scalp. About.

[0002]

2. Description of the Related Art A large number of hair restorer compositions have been proposed in the fields of cosmetics for hair, pharmaceuticals, quasi-drugs, and the like. A hair growth ingredient that promotes blood circulation and stimulates the nipple to promote the generation of hair,
A component having a bactericidal action, a component for preventing dandruff and Kayumi, and the like are blended. And as the hair growth component,
For example, female hormones, vitamin E, pantothenic acid, pepper tincture, ginger tincture, assembly extract, cepharanthin and the like are included.

[0003]

However, in the hair restorer composition containing the conventional hair restorer as described above,
There was also a problem that a sufficient hair-growth effect could not be obtained, and that an unfavorable irritation was given to the scalp.

Accordingly, an object of the present invention is to provide a highly safe hair restorer composition which has an excellent hair restorer action and does not give an unfavorable irritation to the scalp.

[0005]

Means for Solving the Problems The present inventors have made intensive studies to solve the above-mentioned problems, and as a result, have found that brown algae (Pha
When a hair restorer composition is prepared by incorporating Laminaria angusta belonging to the genus Laminaria belonging to the genus Laminaria (eophyta) as a hair restorer, the composition has an excellent hair restorer action and gives an unpleasant stimulus to the scalp. The present inventors have found that a hair restoration composition with high safety and no harm can be obtained, and have completed the present invention.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The Laminaria angusta belonging to the genus Laminaria belonging to the brown algae used in the present invention is a kind of seaweed, and its typical habitat is in the sea in the Hidaka region on the Pacific Ocean side of Hokkaido.

In the present invention, all parts of Laminaria angusta of the genus Laminaria belonging to the above brown algae can be used, and whole plants may be used, or their stems and roots may be used alone. May be used, or a mixture thereof may be used, but a leaf stem is particularly preferable.

In the present invention, the form of use of Laminaria angusta belonging to the genus Laminaria belonging to the brown algae is not particularly limited, and a dry powder or the like may be used as it is.
Further, an extract may be used. Of course, a dry powder and an extract can be mixed and used.

When an extract is used, the extraction solvent used for the extraction is not particularly limited, and an anhydrous or water-containing organic solvent is used in addition to water. Examples of such an organic solvent include those having 1 to 8 carbon atoms such as methanol, ethanol, isopropyl alcohol, n-propyl alcohol, isobutanol, n-hexanol, methyl amyl alcohol, 2-ethylbutanol and n-octanol. C2-C6 such as polyhydric alcohol, ethylene glycol, propylene glycol, 1,3-butylene glycol, hexylene glycol, ethylene glycol monometal ether, ethylene glycol monoethyl ether, propylene glycol monomethyl ether, propylene glycol monoethyl ether, etc.
A polyhydric alcohol or a derivative thereof, a ketone having 3 to 6 carbon atoms such as acetone, methyl acetone, ethyl methyl ketone, isobutyl methyl ketone, and methyl-n-propyl ketone; and a carbon number 4 such as ethyl acetate and isopropyl acetate.
Esters of 5 to 5, ethers having 4 to 8 carbon atoms such as ethyl ether, isopropyl ether and n-butyl ether, and petroleum ethers, and 4 to 8 carbon atoms such as n-butane, n-pentane, n-hexane and n-octane. Aliphatic hydrocarbons, halogenated aliphatic hydrocarbons having 1 to 2 carbon atoms such as carbon tetrachloride, chloroform, dichloroethane, and trichloroethylene; and 6 to 7 carbon atoms such as benzene and toluene.
And anhydrous or hydrated organic solvents such as aromatic hydrocarbons.

[0010] A hair restorer composition can be prepared by using an extract obtained by evaporating the solvent from the extract obtained by the above-mentioned extraction solvent as a hair restorer. In addition, when water is used as the extraction solvent, water is highly safe for the skin, and therefore, without removing the solvent from the extract, the hair restorer composition can be prepared as it is as the hair restorer. . The extract of Laminaria angusta belonging to the genus Laminaria belonging to the brown algae obtained in this manner has an excellent hair-growth effect as is clear from the examples described later, and is derived from natural products. Therefore, it does not give an unfavorable irritation to the scalp and is excellent in safety. As an extract of Laminaria angusta belonging to the genus Laminaria belonging to the brown algae, for example,
It is commercially available from Technoble Co., Ltd. under the trade name of M-034, and is suitably used in the present invention.

The hair restorer composition of the present invention contains, as an essential component, the Laminaria angusta of the genus Laminaria belonging to the above brown algae. Although not limited, as a solid content of Laminaria angusta belonging to the genus Laminaria belonging to brown algae (in the case of the extract extract, a dry solid content of Laminaria angusta belonging to the brown algae belonging to the brown alga used for extraction) 0.005% by weight in the total hair restorer composition
When the amount is less than 0.005% by weight, the effect of Laminaria angusta belonging to the genus Laminaria belonging to the brown algae may not be sufficiently exhibited.
More preferably, the content is set to 15% by weight.

The hair restorer composition of the present invention may further contain, if necessary, female hormones such as ethinylestradiol, oxendron, estradiol, estrone, and pregnanediol, in addition to the above-mentioned Laminaria angusta belonging to the genus Laminaria. Vitamin E or its derivatives, assembly extract, garlic extract, cepharanthin, carpronium chloride, blood circulation promoters such as acetylcholine, capsicum tincture, cantaristin tincture, ginger tincture, local stimulants such as nonylate vanilamide,
Keratolytic agents such as salicylic acid, resorcinol and lactic acid, placenta extract, metabolic activators such as glyceride pentadecanoate, pantothenyl ethyl ether, bition, hinokitiol and allantoin, anti-inflammatory agents such as glycyrrhizic acid and glycyrrhetinic acid, isopropylmethylphenol, triclosan, A bactericide such as zinc pyridione and hinokitiol and a cooling agent such as menthol and camphor can be appropriately compounded.

Further, alcohols, polyhydric alcohols, water-soluble polymers, antioxidants, pH adjusters, UV inhibitors,
Ordinary cosmetic ingredients such as sequestering agents, thickeners, surfactants, purified water, fragrances, preservatives, antibacterial agents, oils, higher fatty acids, fatty acid esters, humectants, pigments, or hormones, vitamins, Crude drug components such as amino acids, astringent, placenta extract, elastin, collagen, mucopolysaccharide, aloe extract, loofah water, royal jelly, birch, carrot extract, chamomile extract, licorice extract, salvia extract, altea extract, and yarrow extract And other special components such as plant and animal extract components may be appropriately added as necessary.

The hair restorer composition of the present invention may be used for cosmetics,
It can be used as a quasi-drug or a pharmaceutical. For example, in cosmetics, in addition to those usually called as a hair restorer, for example, a hair restorer composition in the form of a hair tonic, a hair cream, or a hair treatment May be prepared.

[0015]

EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited to these examples. In the following examples and the like, when expressing the concentration, unless otherwise specified, the percentage is used.
% By weight.

Example 1 M-034 (trade name, manufactured by Technoble Co., Ltd.), which is an aqueous extract of Laminaria angusta belonging to the genus Laminaria belonging to the brown algae, containing 2.5% as a dry solid content of the laminaria angasta The ethanol solution to be used was used as the sample of Example 1.

Comparative Example 1 An ethanol solution containing 2.5% of 1,3-butylene glycol was used as a sample of Comparative Example 1.

The hair growth effects of the samples of Example 1 and Comparative Example 1 were compared by the following test method.

Test Method C3H / Hez Crj mice (8-year-old, weight 21-21)
6g) was acclimated and bred for 1 week or more, and for those without abnormality, the back hair was covered with an electric hair clipper to about 2 cm × 4 c.
m, and the hair was removed with an electric shaver to obtain a sample administration site. 3 days after hair removal, 10
Mice as one group, and 100 μl of each sample of Example 1 and Comparative Example 1 was continuously applied to the mice of each group for 19 days.
Each was applied once a day in the morning. During the test period, the mice were at a temperature of 22 ± 2 ° C., a relative humidity of 55 ± 15%, and a ventilation rate of 2
In a breeding room where the irradiation time was set to 6:00 am to 6:00 pm at 0 times / hour, a plastic cage (14.5 cm × 26 c
mx 12.5 cm).

The state of the sample application site was observed on the first day, the fifth day after the application of the sample, and thereafter every two days until the 19th day, and scored according to the following evaluation criteria, and the average value of 10 animals was calculated. . Table 1 shows the results.

Evaluation Criteria: Skin shows pink ... 0 point Skin changes to gray (less than 100%) ... 1 point Skin changes to gray (100%) ... 2 points Hair growth is brown Change (less than 100%) ... 3 points Hair growth changes to brown (100%) ... 4 points Hair growth changes to black ... 5 points

[0022]

[Table 1]

As is clear from the results shown in Table 1, the group of mice to which the sample of Example 1 was applied had a higher score than the group of mice to which the sample of Comparative Example 1 was applied from day 7 after application. It became clear that Laminaria angusta of the genus Laminaria belonging to the brown algae had an excellent hair-growth effect.

Example 2 The hair restorer composition of Example 2 was prepared according to the following formulation. Extract of 2.5% Laminaria angusta belonging to the genus Laminaria belonging to brown algae (However, as dry solids) Denatured alcohol prescribed by the government 40.0% D-pantothenyl alcohol 0.3% Pantotenyl ethyl ether 0.3% β-Glycyrrhetinic acid 0.1% Tama foxtail alkaloid 0.002% 1-menthol 0.15% Sodium lactate solution (50%) 0.4% Carrot extract 1.5% Common mint extract 0.1% Assembly extract 0.03% 1,3-butylene glycol 0.27% Fragrance 0.11% Purified water Total 100.0%

The hair restorer composition of Example 2 was used for alopecia subjects to examine its hair restorer effect. The test method, the evaluation criteria for the hair growth effect, and the evaluation results of the hair growth effect are as follows.

Test method: As subjects, 9 female alopecia areata, 1 male alopecia areata, 3 female diffuse alopecia,
A total of 15 male alopecia areata and one female alopecia areata were selected in total, and the subjects were given 1 ml of the hair restorer composition of Example 2 twice a day in the morning and evening for 3 months. The composition was applied to the scalp and, after the application, gently massaged to examine its hair growth effect.

Evaluation criteria for hair growth effect:
When the person is aware that hair loss has decreased, or when hair loss has decreased objectively, in the case of alopecia areata, when the size of the hair loss part has stopped increasing, or when new hair can be observed from the hair root It was evaluated as valid and the others were evaluated as invalid.

Evaluation result of hair growth effect: alopecia areata in male 1
No efficacy was confirmed for one person, female alopecia areata, but one male alopecia areata, nine female alopecia areata,
The effectiveness of the hair restorer composition of Example 2 was confirmed such that hair loss was reduced in about one month of use for three female diffuse alopecia.

Example 3 The hair restorer composition of Example 3 was prepared according to the following formulation. Laminaria angusta belonging to the genus Laminaria belonging to brown algae 5.0% crushed product D-pantothenyl alcohol 0.3% pantotenyl ethyl ether 0.3% hinokitiol 0.05% Flavor 0.1% ethanol 40.0% Purification Water total 100.0%

The hair restorer composition of Example 3 was also
When the hair restoration effect was examined in the same manner as in the case of the hair restoration composition of Example 2, the same hair restoration effect as in the case of the hair restoration composition of Example 2 was observed.

Example 4 The aerosol-type hair restorer composition of Example 4 was prepared according to the following formulation. Stock solution: Extract of Laminaria angusta 5.0% of the genus Laminaria belonging to brown algae (However, as solid content) Cepharanthin 0.002% Dipotassium glycyrrhizinate 0.1% Perilla extract 1.0% Fragrance 0.05% Ethanol 65 0.0% Purified water Total 100.0%

Propellant: LPG (20 ° C. 1.5 kg / cm ² ) 86.2% Nitrogen 13.8%

Composition of aerosol-type hair restorer composition: stock solution 97.11% propellant 2.89%

The hair restorer composition of Example 4 was also
When the hair restoration effect was examined in the same manner as in the case of the hair restoration composition of Example 2, the same hair restoration effect as in the case of the hair restoration composition of Example 2 was observed.

[0035]

As described above, according to the present invention, it was possible to provide a highly safe hair restorer composition having excellent hair restorer action and not giving an undesired irritation to the scalp. That is, Laminaria angusta of the genus Laminaria belonging to the brown algae used in the hair restorative composition of the present invention has an excellent hair restoring action, and is also excellent in safety because it is derived from a natural product. The hair restorer composition of the present invention was excellent in hair restorer action, did not give an unfavorable stimulus to the scalp, and was excellent in safety.

 ──────────────────────────────────────────────────続 き Continuing from the front page (72) Katsumi Kanayama 2-17-2 Akakawa, Asahi-ku, Osaka-shi F-term in Milbon Co., Ltd. (reference) 4C083 AA111 AC122 AC302 AC642 AC852 AD532 AD552 CC37 DD08 DD27 EE10 4C088 AA13 AC01 BA07 BA08 MA13 MA17 MA63 ZA92

Claims (2)

[Claims] 1. A hair restorer composition comprising a Laminaria angusta of the genus Laminaria belonging to the brown algae. 2. The amount of Laminaria angusta belonging to the genus Laminaria belonging to the brown algae is 0.005 as a solid content.
The hair restorer composition according to claim 1, wherein the amount is from 15 to 15% by weight.