JP2001354545A - External skin preparation and external skin preparation composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an external skin preparation and an external skin preparation composition having higher inhibitory action on melanin formation than that of a conventional skin whitening agent, not resulting in quality deterioration and the like in the preparation and containing a skin-whitening and skin- beautifying component giving a high medicinal effect. SOLUTION: Disclosed are the external skin preparation containing fruit extracts of kiwifruit belonging to Actinidiaceae, genus actinidia and seed extracts of Coffea arabica belonging to family Coffea arabica, genus Coffea arabica, and the external skin preparation composition containing a pharmaceutically active agent selected from the fruit extracts of kiwifruit, the seed extracts of Coffea arabica a skin-whitening agent, an antioxidant, an anti-inflammatory agent, an ultraviolet inhibitor, a sterilizer, a moisturizing agent and a cell activator.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an extract of the family Actinaceae, an extract of the fruit of the Kiwi fruit of the genus Actinaceae and a family of Rubiaceae,
The present invention relates to a skin external preparation containing an extract of coffee tree seeds of the genus Coffee tree, and a skin external preparation composition obtained by combining the same with other medicinal ingredients.

[0002]

2. Description of the Related Art Conventionally, skin external preparations such as emulsions, creams, lotions, packs, cleansing agents, dispersions, ointments, and external preparations have been treated with various medicinal effects in order to impart predetermined medicinal effects thereto. Ingredients have been added. For example, whitening agents such as ascorbic acid, glutathione, and hydroquinone have been added to prevent phenomena such as darkening of the skin caused by sunburn, pigmentation, and spots and freckles caused by pigmentation.

[0003]

However, in many cases, these whitening agents do not have sufficient whitening / skinning effects, or do not have the desired medicinal effect due to deterioration in the preparation. Improvement was desired.

[0004]

Means for Solving the Problems The present inventors have conducted an intensive search for natural ingredients that have excellent medicinal properties and can be used as medicinal ingredients in skin external preparations.
It is a whitening / skin component that has a high melanin production inhibitory effect and is an excellent effect by combining the extract of the fruit of the genus Actinidia, the genus Kiwi fruit of the genus Actinidia, and the extract of the seeds of the genus Rubiaceae and the genus Coffeefruit. Was found. And these extracts, furthermore, found that a more excellent effect as a skin external preparation composition can be obtained by combining with other medicinal ingredients,
The present invention has been completed.

More specifically, the present invention comprises the following components (A) and (B): (A) a fruit extract of a Kiwifruit belonging to the family Rubiaceae and the genus Rubiaceae; (B) an extract of coffee tree seeds belonging to the genus Rubiaceae; It is intended to provide a skin external preparation having an excellent whitening / beautiful skin effect, improving pigmentation and improving skin transparency.

Further, the present invention provides the following components (A) and (B)
And (C) (A) Extract of the fruit of the genus Matabiaceae, Kiwifruit of the genus Agaricus (B) Extract of the seeds of the seeds of the genus Rubiaceae and of the genus Coffeefruit (C) Whitening agents, antioxidants, anti-inflammatory agents, and UV inhibitors The present invention provides a composition for external use on the skin, characterized in that it contains one or more medicinal agents selected from the group consisting of a bactericide, a humectant and a cell activator.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The extract of kiwifruit fruit which is the component (A) of the present invention can be obtained by extracting the fruit of kiwifruit according to a conventional method. Kiwifruit, which is the raw material, belongs to the genus Matabida, and its scientific name is
Actinidia chinensis Planch (Actinidiaceae), native to New Zealand.

[0008] On the other hand, an extract of coffee tree seeds is obtained by extracting coffee tree seeds according to a conventional method. This raw material, coffee tree, belongs to the genus Rubiaceae, and its scientific name is Coffea arabica Linne or its congener plant (Rubiaceae), which is native to South America.
However, in producing the extract of either the component (A) or the component (B) used in the present invention, the type and place of production are not particularly limited.

The method for preparing the extract of component (A) or component (B) from the fruit of the kiwifruit or the seeds of coffee tree is not particularly limited. For example, the extract may be dried or cut without drying. After that, a method of extracting with a solvent at a low temperature or at a normal temperature to a heating temperature can be mentioned.

As an extraction solvent, generally, water, low-grade 1
Polyhydric alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (propylene glycol, 1,3-butylene glycol, etc.), lower alkyl esters (ethyl acetate, etc.) ), Hydrocarbons (benzene, hexane, pentane, etc.), ketones (acetone, methyl ethyl ketone, etc.), ethers (diethyl ether, tetrahydrofuran, dipropyl ether, etc.), acetonitrile and the like.

As a preferred example of the extraction method, ethyl alcohol having a water content of 0 to 100% by volume or 1, 1 vol.
Extraction is performed at room temperature for 1 to 5 days using 3-butylene glycol, followed by filtration, and the obtained filtrate is left to mature for about one week, followed by filtration again.

Component (A) in the external preparation for skin of the present invention
And the content of the component (B) is preferably 0.00001 to 5% by mass (hereinafter simply referred to as "%") as a dry solid content, and more preferably 0.0001 to 5%.
2%. Within this range, the component (A) and the component (B) can be stably compounded and have high whitening,
A beautiful skin effect can be exhibited. When the component (A) and / or the component (B) is used as an extract, the concentration of the extract is not limited as long as the content of the dry solid as a solute is within the above range. Absent.

The components (A) and (B) of the present invention comprise:
According to a conventional method as a skin whitening / beautifying skin component, it can be blended with various forms of bases used in normal skin external preparations and formulated to give a skin external preparation. By combining with the above, an external preparation for skin with more excellent whitening and skin effect can be obtained.

Further, in the present invention, other medicinal components (component (C)) used in combination with the components (A) and (B) include a whitening agent, an antioxidant, an anti-inflammatory agent, and an ultraviolet ray preventing agent. It is a medicinal agent selected from agents, fungicides, humectants and cell activators. Specific examples of the component (C) include the following.

(Whitening agent) As a whitening agent, vitamin C and its derivatives and salts thereof, placenta extract, licorice extract, yokuinin extract, asparagus extract, oedum extract, raspberry extract, jinjin extract Tea extract, such as stuff, cinnamon extract, kokahi extract, rice bran extract, wheat germ extract, saishin extract, hawthorn extract, white lily extract, peony extract, soybean extract, green tea, black tea, oolong tea, Molasses extract, liquorice extract, beech sprouts extract, grape extract, hops extract, squid extract, mocca extract and arhat extract, squirrel extract, seaweed extract and the like. Among these whitening agents, particularly preferred are vitamin C and its derivatives, salts thereof, and placental extracts.

(Antioxidants) Examples of antioxidants include mannitol, rutin and its derivatives, quercetin, phospholipids, vitamins A (carotenoids such as beta-carotene, astaxanthin, dehydroretinal, carotene, etc.), pyridoxines ( Pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), nicotinic acids (nicotinamide, benzyl nicotinate, etc.), dibutylhydroxytoluene (BHT), butylhydroxyanisole (BHA), vitamin E and its derivatives and their salts, carrot extraction , Melissa extract, Jasazi extract and the like. Among these antioxidants, particularly preferred ones include vitamin E and its derivatives and salts thereof.

(Anti-inflammatory agent) As anti-inflammatory agents, chondroitin sulfate and its derivatives, allantoin, arnica extract, hypericum extract, oak extract, goldfish extract, watercress extract, comfrey extract,
Salvia extract, Shikon extract, Birch extract, Calendula extract, Elderberry extract, Asparagus extract, Mukuroji extract, Eucalyptus extract, Astragalus extract, Glycyrrhizic acid, Glycyrrhetinic acid and derivatives thereof and salts thereof , Aloe extract, perilla extract, mugwort extract, chamomile extract and the like. Among these anti-inflammatory agents, particularly preferable ones include glycyrrhizic acid, glycyrrhetinic acid and their derivatives and salts thereof.

(Ultraviolet ray inhibitor) As ultraviolet ray inhibitors, sodium 2-hydroxy-4-methoxybenzophenone-5-sulfonate, paramethoxycinnamic acid-
2-ethylhexyl, oxybenzone, 4-tert-
Butyl-4'-methoxydibenzoylmethane, titanium oxide, fine particle titanium oxide, zinc oxide and the like.
Among these ultraviolet inhibitors, particularly preferred are 2-ethylhexyl paramethoxycinnamate, titanium oxide, fine particle titanium oxide, and zinc oxide.

(Bactericide) Examples of the bactericide include salicylic acid and salts thereof, isopropylmethylphenol, hinokitiol, and photosensitizer. Of these fungicides, particularly preferred are salicylic acid and its salts, and isopropylmethylphenol.

(Humectant) Examples of the humectant include alkaline hot spring water, deep water, mucopolysaccharides or derivatives thereof, saccharides, ceramide, urea, D-panthenol, gentian extract, cactus extract, and mallow. Extracts, lupine bean extracts, yokunin extracts, prune extracts, Butchers bloom extracts, marronnier extracts and the like. Among these humectants, particularly preferred are deep water, D-panthenol, gentian extract, and prune extract.

(Cell activator) Examples of cell activators include vitamin A and its derivatives, citric acid, lactic acid, tartaric acid, malic acid, glycolic acid, succinic acid, serine, glutamic acid, hydroxyproline, theanine, and pyrrolidone carboxylic acid. , Yeast extract, lactic acid bacteria extract, bifidobacterium extract, fermentation metabolic extract and the like. Among these cell activators, particularly preferred are vitamin A and its derivatives, citric acid, lactic acid, malic acid, serine, and pyrrolidone carboxylic acid.

The content of the component (C) in the composition for external use on skin of the present invention varies depending on the kind of the medicinal agent.
It is preferable to set the following range. Within this range, when combined with component (A) and component (B),
It is possible to exhibit higher whitening and beautiful skin effect without affecting the temporal stability of the extract of the components (A) and (B) in the preparation.

That is, in the skin external preparation composition of the present invention, the blending amount of the whitening agent as the component (C) is preferably 0.00001 to 10%, more preferably 0.0001 to 5%. % Range. When the extract is used as it is, there is no problem as long as the dry solid content is within this range. Within this range, a skin external preparation composition exhibiting more excellent whitening / skinning effects and having a good feeling in use can be obtained.

In the composition for external preparation for skin of the present invention, the amount of the antioxidant to be added as component (C) is preferably 0.00001 to 5%, more preferably 0.0001 to 3%. Range. When the extract is used as it is, there is no problem as long as the dry solid content is within this range. Within this range, a more excellent antioxidant effect can be obtained, and a skin external preparation composition exhibiting excellent whitening and skin beautiful effects can be obtained.

Further, in the skin external preparation composition of the present invention, the compounding amount when the anti-inflammatory agent is added as the component (C) is preferably in the range of 0.00001 to 5%, more preferably 0.0001%. ３3%. When the extract is used as it is, there is no problem as long as the dry solid content is within this range. Within this range, a skin external preparation composition exhibiting an excellent anti-inflammatory effect and exhibiting excellent whitening and skin effect can be obtained.

Furthermore, in the skin external preparation composition of the present invention, when the ultraviolet ray inhibitor is added as the component (C), the amount is preferably 0.0001 to 20%, more preferably 0.001 to 20%. It is in the range of 10%. If it is in this range, it will exhibit a better UV protection effect, and
A skin external preparation composition exhibiting excellent whitening and skin effect can be obtained.

On the other hand, in the skin external preparation composition of the present invention, the compounding amount when a bactericide is compounded as the component (C) is preferably in the range of 0.00001 to 5%, more preferably 0.1 to 5%. It is in the range of 000-1%.
If it is in this range, it will exhibit a better bactericidal effect, and
A skin external preparation composition exhibiting excellent whitening and skin effect can be obtained.

In addition, when the humectant is added as the component (C) in the skin external preparation composition of the present invention, the compounding amount is preferably in the range of 0.00001 to 50%, and more preferably 0%. 0.0001 to 20%. Within this range, a skin external preparation composition that exhibits a more excellent moisturizing effect and also has an excellent whitening and skin effect can be obtained.

In addition, in the skin external preparation composition of the present invention, when the cell activator is added as the component (C), the amount is preferably in the range of 0.00001 to 5%, more preferably. Is in the range of 0.0001 to 3%. When the extract is used as it is, there is no problem as long as the dry solid content is within this range. Within this range, a skin external preparation composition exhibiting a more excellent cell activating effect and exhibiting an excellent whitening and skin effect can be obtained.

These components (C), ie, a whitening agent, an antioxidant, an anti-inflammatory agent, an ultraviolet ray inhibitor, a bactericide, a humectant and a cell activator can be used alone or in combination of two or more. .

A skin external preparation composition obtained by combining the above components (A), (B) and (C) is also prepared according to a conventional method, as essential components (A), (B) and (C). ) Is mixed with various types of bases known as usual external preparations for the skin, and formulated into a formulation.

Examples of the form of the external preparation for skin and the composition for external preparation for skin are not particularly limited, and examples thereof include cosmetics such as emulsions, creams, lotions, packs, detergents, makeup cosmetics, dispersions and ointments. Drugs and external medicines.

Further, depending on the form of the external preparation for skin and the external preparation composition for skin, in addition to the above essential components, components usually used in external preparations for skin such as cosmetics and pharmaceuticals, for example, purified water,
Lower alcohols, polyhydric alcohols, oily components, powders, surfactants, thickeners, coloring materials, preservatives, fragrances, and the like can be used.

[0034]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples and Examples, but the present invention is not limited thereto.

Reference Example 1 Preparation of Kiwifruit Fruit Extract: Kiwifruit fruit extract was obtained by adding 30 ml of water to 10 g of kiwifruit fruit, extracting at room temperature for 3 days, and filtering. The dry solids content of this extract was 1.5%.

REFERENCE EXAMPLE 2 Production of an extract of coffee tree seed: coffee tree seed 1
To 0 g, 100 ml of 70% by volume ethyl alcohol was added, extracted at room temperature for 3 days, and then filtered to obtain an extract of coffee tree seeds. At this time, the dry solid content of the extract of coffee tree seeds was 1.9%.

Test Example 1 Test for inhibition of melanin production and cell viability by cell culture:
B16 melanoma cultured cells derived from mice were used as test cells, and melanin production inhibition and cell viability were examined. An appropriate amount of MEM medium supplemented with 10% FBS (manufactured by Nissui Pharmaceutical Co., Ltd.) was taken in two 6-well dishes, B16 melanoma cells were inoculated, and allowed to stand at 37 ° C. and 5% carbon dioxide concentration.
The next day, the kiwifruit fruit extract and the coffee tree seed extract obtained in Reference Examples 1 and 2 were brought to a final concentration of 0 (control), the kiwifruit fruit extract was 50,100 μg / ml, and the coffee tree was extracted. The seed extract was adjusted to be 10,30 μg / ml, and the obtained sample preparation was added to the medium and mixed. On the fifth day of the culture, the medium was replaced, and the sample preparation solution was added again. On the next day, the medium was removed, and one petri dish was washed with a phosphate buffer and then collected. The degree of whitening of the cultured B16 melanoma cells was evaluated according to the following criteria.

(Criteria for determining the degree of whitening) <Judgment> <Contents> ++: Very white with respect to the control. +: Clearly white with respect to the control. ±: slightly white with respect to the control. -: The same black color as the control.

For the remaining one petri dish, the cells were fixed in formalin and stained with a 1% crystal violet solution. Cell viability for each sample concentration was measured with a monocerator (Olympus). Table 1 shows the results of the viability and the degree of whitening measured above.

(Result)

[Table 1]

As is evident from the results in Table 1, both the kiwifruit fruit extract and the coffee tree seed extract have high melanin production inhibitory activity and low toxicity on cultured B16 melanoma cells. Was.
Furthermore, it was confirmed that the combined addition of the extract of the kiwifruit fruit and the extract of the coffee tree seeds synergistically enhances the melanin production-inhibiting effect without causing cell toxicity. Therefore, the external preparation for skin of the present invention containing the plant extract exerts an extremely excellent melanin production inhibitory effect by applying it to the skin, and has an effect of blackening the skin due to sunburn, spots and freckles. It can be expected to have a whitening and skin effect.

EXAMPLE 1 Cream: A cream was prepared according to the composition shown in Table 2 and by the following method, and the whitening and skin whitening effects of an extract of a kiwifruit fruit and an extract of a coffee tree seed were examined. Table 2 shows the results.

(Composition and Results)

[Table 2]

(Production method) Components (1) to (6), (11), (13), (1)
4), (16) and (17) are mixed and heated to 70 ° C. B. Heat a portion of component (19) and maintain at 70 ° C. C. B was added to A and dissolved in the remainder of (7) to (9), (18) and (19) (10), (12), (1)
After mixing 5), the mixture was cooled to obtain a cream.

(Test method) 2 per test cream
A panel consisting of 15 women aged 7-54 years
After washing the face for 12 weeks, an appropriate amount of the test cream was applied to the face. The whitening and skin effect by coating were evaluated according to the following criteria.

(Evaluation Criteria) <Evaluation> <Contents> Effective: The dullness of the skin became less noticeable. Slightly effective: Skin dullness became less noticeable. Ineffective: No change from before use.

As shown in the results in Table 2, Comparative Examples 1 and 4 to 11 which did not contain the extract of the kiwifruit fruit and the extract of the coffee tree seeds, the extract of the kiwifruit fruit and the extract of the coffee tree seeds A In comparison with Comparative Examples 2 and 3, which were individually blended, the external preparation of the present invention containing the extract of the kiwifruit fruit and the extract of coffee tree seeds was applied to the skin by applying these to the skin.
Prevents and improves the appearance of skin dullness, etc.
It became clear to have beautiful skin. Furthermore, the present invention 2 to which an extract of kiwifruit fruit and an extract of coffee tree seeds are combined with a whitening agent, an antioxidant, an anti-inflammatory agent, an ultraviolet inhibitor, a bactericide, a humectant and a cell rejuvenating agent are combined. By applying the external preparation composition of No. 9 to the skin, the effect of preventing and improving the occurrence of “dullness” on the skin is more synergistic than in the case of applying the external preparation of the present invention 1 not containing these medicinal agents. It became clear that the skin was enhanced and beautiful.

Example 2 Lotion: (Composition) (%) (1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20EO) 2 Sorbitan monolaurate (4) Ethyl alcohol 8.0 (5) Kiwi fruit fruit extract ^{* 1} 1.0 (6) Coffee tree seed extract ^{* 2} 1.0 (7) Preservatives Appropriate amount (8) Fragrance Appropriate amount (9) Remaining purified water * 1: Manufactured in Reference Example 1 * 2: Manufactured in Reference Example 2

(Production method) Components (3), (4), (7) and (8) are mixed and dissolved. B. Components (1), (2), (5), (6) and (9) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

The lotion obtained in Example 2 has excellent stability over time and, when applied to the skin, prevents "dullness" of the skin due to sunburn, spots and freckles, and gives a clear and beautiful skin. Met.

Example 3 Emulsion: (Composition) (%) (1) Polyoxyethylene (10EO) 1.0 Sorbitan monostearate (2) Polyoxyethylene (60EO) 0.5 Sorbit tetraoleate (3) Glyceryl monostearate 1.0 (4) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Kiwi fruit fruit extract ^{* 1} 3.0 (8) Coffee tree seed extract ^{* 2} 2.0 (9) Placenta extract ^{* 3} 0.1 (10) dl-α-tocopherol acetate ^{* 4} 0.05 (11) Preservative 0.1 (12) Carboxy Vinyl polymer 0.1 (13) Sodium hydroxide 0.05 (14) Ethyl alcohol 5.0 (15) Remaining purified water (16) Appropriate perfume * 1: Produced in Reference Example 1 2: those that have been prepared in Reference Example 2 * 3: Nichirei * 4: Eisai Co., Ltd.

(Production method) The components (12) to (15) are mixed by heating and kept at 70 ° C. B. Heating and mixing components (1) to (6) and (10),
Keep at 70 ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, (7) to (9), (11) and (1)
6) was added and mixed uniformly to obtain an emulsion.

The emulsion obtained in Example 3 was used in combination with the extract of kiwifruit fruit, the extract of coffee tree seeds, the extract of placenta and the dl-α-tocopherol acetate to obtain “stained skin” and stains due to sunburn. The effect of preventing skin flecks and freckles and making the skin beautiful and transparent was more excellent.

Example 4 Ointment: (Prescription) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Kiwifruit fruit extract ^{* 1} 1.0 (6) Coffee tree seed extract ^{* 2} 0.1 (7) Dipotassium glycyrrhizinate ^{* 3} 0.1 (8) Lactic acid ^{* 4} 0.2 (9) Purified water residue Amount * 1: Manufactured in Reference Example 1 * 2: Manufactured in Reference Example 2 * 3: Maruzen Pharmaceutical Co., Ltd. * 4: Daiichi Pharmaceutical Co., Ltd.

(Production method) A. A part of the components (3), (4), (8) and (9) are mixed by heating and kept at 75 ° C. B. Heat and mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. While cooling C, (7) dissolved in the rest of (5), (6) and (9) was added to obtain an ointment.

The ointment obtained in Example 4 has excellent stability over time,
By using an extract of a kiwifruit fruit, an extract of a coffee tree seed, and dipotassium glycyrrhizinate and lactic acid together, it was possible to prevent "dullness", spots and freckles, and to make the skin more transparent and beautiful.

Example 5 Pack: (Preparation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Kiwi Fruit fruit extract ^{* 1} 1.0 (6) Coffee tree seed extract ^{* 2} 1.0 (7) Stearyl glycyrrhetinate ^{* 3} 0.1 (8) dl-α-tocopherol acetate ^{* 4} 0.2 (9 ) Wheat germ extract ^{* 5} 1.0 (10) Preservative 0.2 (11) Perfume 0.1 (12) Purified water Remaining * 1: Manufactured in Reference Example 1 * 2: Manufactured in Reference Example 2 * 3: Maruzen Pharmaceutical Co., Ltd. * 4: Eisai Co., Ltd. * 5: SILAB Co., Ltd.

(Production method) Mix components (1), (3), (4) and (12), heat to 70 ° C. and stir. B. Mix components (2), (7), (8) and (10). C. The above B was added to the above A, mixed, cooled, and (5), (6), (9) and (11) were uniformly dispersed to obtain a pack.

The pack obtained in Example 5 was excellent in stability over time and, when applied to the skin, prevented "smearing" and spots on the skin, and made the skin transparent and beautiful.

Example 6 Liquid foundation: (Preparation) (%) (1) Lanolin 7.0 (2) Liquid paraffin 5.0 (3) Stearic acid 2.0 (4) Cetanol 1.0 (5) Paramethoxycinnamic acid 3.0-2-ethylhexyl ^{* 1} (6) Glycerin 5.0 (7) Triethanolamine 1.0 (8) Carboxymethylcellulose 0.7 (9) Purified water Remaining (10) Titanium oxide 8.0 (11) Fine particle titanium oxide 2.0 (12) Zinc oxide 5.0 (13) Mica 15.0 (14) Talc 6.0 (15) Color pigment 6.0 (16) Kiwi fruit fruit extraction things ^* 2 0.01 (17) Coffea extract ^* 3 0.05 (18) prune extract ^* 4 0.5 (19) perfume Appropriate amount * 1: BASF Co. * 2: prepared in reference example 1 Roh * 3: those that have been prepared in Reference Example 2 * 4: Maruzen Pharmaceuticals Co., Ltd.

(Production method) Components (1) to (5) are mixed and dissolved. B. Add components (10) to (15) to A, mix uniformly, and keep at 70 ° C. C. Components (6) to (9) are uniformly dissolved and kept at 70 ° C. D. Add C to B and emulsify uniformly. E. FIG. After cooling D, components (16) to (19) were added to obtain a liquid foundation.

[0062] Kiwifruit fruit extract and coffee tree seed extract of Example 6, paramethoxycinnamic acid-2
-A liquid foundation using ethylhexyl and prune extract in combination has excellent stability over time, and when applied to the skin, is extremely excellent in preventing skin darkening due to sunburn and preventing spots and freckles. Was.

[0063]

As described above, the external preparation for skin containing the kiwifruit fruit extract and the coffee tree seed extract of the present invention has a melanin production inhibitory action,
It exerts a high inhibitory effect on pigmentation and is effective in preventing and improving skin darkening due to dull skin, sunburn, etc., spots and freckles.

In addition to the extract of kiwifruit fruit and the extract of coffee tree seeds, other medicinal ingredients such as whitening agents, antioxidants, anti-inflammatory agents, ultraviolet inhibitors, bactericides, moisturizers and cell activators. The skin external preparation composition of the present invention, which contains the above-mentioned extract, has more excellent whitening and skin effect than the case where the above-mentioned extract is used alone.

Accordingly, the external preparation for skin and the external composition for skin of the present invention can be advantageously used as cosmetics and medicines for whitening and beautiful skin.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 U 35/78 35/78 W A61P 17/16 A61P 17/16 F term ( Reference) 4C083 AA072 AA082 AA111 AA112 AB032 AB212 AB242 AB432 AB442 AC012 AC022 AC072 AC102 AC122 AC242 AC302 AC342 AC422 AC442 AC472 AC542 AC642 AD092 AD112 AD272 AD532 AD622 AD642 AD662 BB46 BB47 BB48 BB51 CC04 CC05 CC07 CC12 AB14 MA07 MA63 NA14 ZA89 ZC41

Claims (2)

[Claims] 1. The following components (A) and (B): (A) an extract of a kiwi fruit fruit belonging to the family Rubiaceae and Rubiaceae; External preparation for skin. 2. The following components (A), (B) and (C): (A) an extract of the fruit of the genus Agariidae and the kiwi fruit of the genus Agaricus (B); A skin external preparation composition comprising one or more active agents selected from whitening agents, antioxidants, anti-inflammatory agents, ultraviolet inhibitors, bactericides, humectants, and cell activators.