JP2001009028A - Dissolution apparatus and method of using the same - Google Patents

Abstract

(57) [Problem] To provide a dissolving apparatus and a method for using the same, which can facilitate an additional dissolving operation of a stock solution for dialysis and can reduce a maintenance operation. In a dissolving apparatus for dissolving a dialysis powder drug to obtain a dialysis stock solution, dissolution tanks 1 and 2 containing the dialysis stock solution.
A water supply line for supplying water for dissolving the dialysis powder drug to the dissolving tanks 1 and 2, and a liquid level detecting means capable of continuously detecting a liquid level of the undiluted dialysis solution produced by the water supply line 3, a calculating means 9 for calculating the volume of the stock solution for dialysis in the dissolving tanks 1 and 2 from the liquid level detected by the liquid level detecting means 3, and And a supply line for supplying a stock solution.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a dissolving apparatus for dissolving a powdered dialysis drug, which becomes a stock solution for dialysis to be used for hemodialysis when dissolved in water, to a predetermined concentration.

[0002]

2. Description of the Related Art Dialysates used for treating renal failure patients in hospitals and the like are generally classified into bicarbonates and acetic acids. Among them, bicarbonate dialysates contain sodium bicarbonate. It is prepared by mixing water with two kinds of chemicals, which are not present (hereinafter referred to as agent A) and sodium bicarbonate (hereinafter referred to as agent B).

[0003] In recent years, from the viewpoint of improving the transportability, attempts have been made to dissolve a powdered version of these agents A and B (hereinafter referred to as a dialysis powder drug) before dialysis. The concentration of the solution (particularly, agent B) was liable to decrease with time, and it was difficult to make a reserve for the next day after dialysis.

[0004] For this reason, a dissolving operation is required for each dialysis, and various dissolving apparatuses for dissolving have been conventionally proposed. For example, Japanese Patent Application Laid-Open No. 57-159529 discloses a dissolving apparatus in which two dissolving tanks are provided side by side, and a dialysis stock solution stirred and generated in each dissolving tank is sent to an artificial dialysate supply device.

Each of the dissolving tanks is provided with a plurality of liquid level detecting means for detecting the liquid level of the accommodated undiluted dialysis solution at regular intervals. It was configured to detect the liquid level from the disposition position. With this configuration, periodic cleaning can be performed alternately, which is hygienic, and a sudden trouble of one dissolving device can be dealt with only by the other dissolving device.

[0006]

However, in the conventional dissolving apparatus described above, of the plurality of liquid level detecting means disposed at regular intervals, the liquid level detecting means reacting to the liquid level is provided. Since the liquid level is detected from the position, there is a problem that, for example, when additional lysis is necessary in a state where the stock solution for dialysis remains in the dissolution tank, the additional work is troublesome. That is, prior to detecting the volume of the added dialysis stock solution, the volume of the dialysis stock solution remaining in the dissolution tank must first be detected. After the dialysis stock solution was drained to lower the liquid level to the required level, additional dissolution had to be performed.
In addition, a plurality of liquid level detecting means must be arranged at an accurate position in one dissolving tank, and there is a problem that maintenance work is increased.

[0007] The present invention has been made in view of such circumstances, and provides a dissolving apparatus and a method for using the dissolving apparatus, which can facilitate an additional dissolving operation of a stock solution for dialysis and can reduce maintenance operations. With the goal.

[0008]

According to the first aspect of the present invention,
In a dissolving apparatus for dissolving the dialysis powder drug to obtain a dialysis stock solution, a dissolution tank containing the dialysis stock solution, and a water supply line for supplying water for dissolving the dialysis powder drug to the dissolution tank, Liquid level detection means capable of continuously detecting the liquid level of the undiluted solution for dialysis dissolved and produced by the water supply line,
Calculating means for calculating the volume of the undiluted solution for dialysis in the dissolving tank from the liquid level detected by the liquid level detecting means, and a supply line for supplying the undiluted solution for dialysis from the dissolving tank to a dialysate supply device, It is characterized by having.

According to this structure, the dissolving tank containing the dialysis powder drug is supplied with water through the water supply line, and the liquid level of the undiluted dialysis solution generated by dissolution of the dialysis powder drug is detected by the liquid level detecting means. While detecting, the dialysis stock solution is supplied to the dialysis solution supply device by the supply line. At the time of additional dissolution of the undiluted dialysis solution, the level of the remaining undiluted dialysis solution is detected, and the value obtained by subtracting the volume calculated by the calculating means from the liquid level from the total volume after the water supply is the added volume. Become. The liquid level detecting means is
Since the liquid level in the dissolving tank can be continuously detected, it is necessary to perform operations such as discharging the undiluted dialysis solution and lowering it to a detectable liquid level when detecting any liquid level in additional dissolution work etc. Absent.

According to a second aspect of the present invention, the dissolving tank comprises a first dissolving tank and a second dissolving tank provided side by side, and a predetermined one of the undiluted dialysis solutions generated by supplying water into the first dissolving tank. A connecting line for flowing the undiluted solution for dialysis exceeding the liquid level to the second dissolving tank, and detecting the undiluted solution for dialysis flowing out of the connection line with the liquid level detecting means; A total volume of the dissolved undiluted dialysis solution is calculated from a volume calculated from the liquid level detected by the liquid level detecting means and a volume converted from a predetermined liquid level in the first dissolving tank. And

[0011] According to this configuration, the dialysis powder medicine contained in the first dissolving tank is supplied with water through the water supply line, and the undiluted dialysis solution exceeding the predetermined liquid level in the first dissolving tank is connected to the connecting line. After flowing out to the second dissolving tank side, the volume of the dialysis stock solution in the second dissolving tank is detected from the liquid level detected by the liquid level detecting means. The total volume of the prepared undiluted dialysis solution is calculated by calculating the volume calculated by the calculating unit based on the liquid level detected by the liquid level detecting unit and the volume converted from the predetermined liquid level in the first dissolving tank. It is determined by doing. Then, the prepared dialysis stock solution is sent from the first dissolution tank or the second dissolution tank to the dialysate supply device by a supply line.

According to a third aspect of the present invention, the liquid level detecting means detects the liquid level of the undiluted dialysis solution in the dissolving tank and calculates the volume by the calculating means. Water is added to the dissolving tank, and after the addition, the liquid level detecting means again detects the liquid level of the undiluted dialysis solution in the dissolving tank, calculates the volume by the calculating means, The volume of the dialysis stock solution before the addition is subtracted from the volume of the dialysis stock solution after the addition, and the volume of the additional dialysis stock solution is calculated.

[0013]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a first embodiment and a second embodiment of the present invention will be specifically described with reference to the drawings. First, the dissolution apparatus according to the first embodiment includes:
Dissolving the dialysis powder drug to obtain a dialysis stock solution,
As shown in FIG. 1, a second dissolving tank 1 and a first dissolving tank 2 as dissolving tanks, a liquid level detecting unit 3, showers 4 and 5,
A connection line 6, a disinfection unit 7, a concentration cell 8, a calculation means 9, a water supply means 10, a chamber 12, a plurality of valves V1 to V8 and a line connecting these valves, a filter F1, a pump P Mainly composed of

The second dissolving tank 1 is a tank for storing the dialysis stock solution, and has a liquid level detecting means 3 for detecting the level of the stored dialysis stock solution at the upper part. This liquid level detecting means 3
The liquid level of the undiluted dialysis solution dissolved and generated by the water supply line can be continuously detected. As shown in FIG. 2 or FIG. 3, the dialysis stock solution includes, for example, an ultrasonic liquid level sensor 3a or a magnetostrictive displacement sensor 3b. .

The ultrasonic liquid level sensor 3a is capable of continuously detecting the liquid level of the undiluted dialysis solution using high frequency,
It is fixed to the upper part of the second dissolution tank 1 so as to face the liquid level of the stock solution for dialysis in the second dissolution tank 1. As shown in FIG. 2, the ultrasonic liquid level sensor 3a has a transmitting unit that transmits ultrasonic waves and a receiving unit that receives ultrasonic waves. When the liquid level is detected,
The ultrasonic pulse is transmitted from the transmitting unit, and the time until the reflected wave reflected on the liquid surface of the undiluted solution for dialysis is received by the receiving unit is measured, and the ultrasonic liquid level sensor is obtained from the measured value. The distance a from 3a to the liquid level can be determined.

On the other hand, the distance c from the ultrasonic liquid level sensor 3a to the bottom of the second dissolving tank 1 is a predetermined value depending on the fixed position of the ultrasonic liquid level sensor 3a. At the liquid level b. Note that the liquid level may be obtained without performing the subtraction by using a conversion matrix that converts the liquid level b from the detected value a.

As shown in FIG. 3, the magnetostrictive displacement sensor 3b has a magnetostrictive wire 3ba and a magnet 3bb made of metal, and flows through the magnetostrictive wire 3ba to float on the liquid surface.
By detecting the position of bb, the liquid level of the stock solution for dialysis can be continuously detected. This is because the magnetic field generated by the current flowing through the magnetostrictive wire 3b is
bb is locally distorted. This distortion is a kind of vibration, and propagates at the speed of sound on the magnetostrictive wire 3ba, which is a metal. By measuring the propagation time, the position of the magnet 3bb can be accurately detected. If the position of the magnet 3bb floating on the liquid surface can be detected in this way, the liquid level of the dialysis stock solution can be recognized by a conversion matrix or the like.

The ultrasonic liquid level sensor 3a and the magnetostrictive displacement sensor 3b can continuously detect the liquid level of the undiluted dialysis solution in the second dissolving tank 1, so that any liquid such as additional dissolving operation can be performed. When detecting the level, it is not necessary to discharge the undiluted dialysis solution to lower the level to a detectable level. Note that, instead of the ultrasonic liquid level sensor 3a and the magnetostrictive displacement sensor 3b, another sensor that continuously detects the liquid level of the dialysis stock solution may be used.

When the liquid level is detected by the liquid level detecting means 3,
The detected value is transmitted to the calculating means 9 as an electric signal.
When a signal is sent to the arithmetic means 9, an operation for converting the level of the undiluted dialysis solution into the volume of the undiluted dialysis solution is performed, and the volume of the undiluted dialysis solution accommodated in the second dissolution tank 1 is recognized. .

On the upper part of the inner wall of the second dissolving tank 1, the second dissolving tank 1
A shower 4 for cleaning the inside is attached, and is connected to the water supply means 10 via lines L1 to L5. A valve V1 is interposed in the line L2, and a pump P is interposed in the line L3. When the valve P1 is opened while driving the pump P, water can be sprayed from the shower 4 into the second dissolving tank 1.

A line L6 extends from an opening 1a at the corner of the bottom of the second dissolving tank 1, and a line L8 extends from an opening 1b at the center of the bottom of the second dissolving tank 1. L3 and the line L8 are connected to the intersection of L12 and L11, respectively.

Further, the opening 1a is covered with the filter F1, and when the pump P is driven, the undiluted dialysis solution filtered by the filter F1 passes through the lines L6, L3, L4, L12 and L8 from the opening 1b. It is returned to the second dissolution tank 1.
By such a circulation, the stock solution for dialysis in the second dissolution tank 1 can be stirred, and a stock solution for dialysis having a uniform concentration can be obtained.

A line L10 extends from an opening 1c in the side wall of the second melting tank 1, and this line L10 is connected via a line 11 to the intersection of the line L12 and the line L8. A concentration cell 8 is provided on the line L11,
The concentration of the stock solution for dialysis passing through the line L11 can be measured. Note that a disinfecting unit 7 is disposed above the second dissolving tank 1, and the disinfecting liquid supplied from the disinfecting unit 7 can disinfect the second dissolving tank 1 or the inside of the line.

The first dissolving tank 2 is a tank having a relatively smaller capacity than that of the second dissolving tank 1, and is provided in parallel with the second dissolving tank 1 and capable of storing a predetermined amount of dialysis powder drug. I have. A line L13 extends from an opening 2a at the center of the bottom surface of the first dissolving tank 1, and this line L13 is connected to the water supply means 10 via lines L14, L4, L3, L2, and L1. Further, a valve V2 is provided in the line L14, and the valve V2 and the valve V1 are provided.
When the pump is opened and the pump P is driven, water can be supplied into the first dissolving tank 2. The lines L1, L2,
The line formed by L3, L4, L14 and L13 is the first line
A water supply line for supplying water for dissolving the dialysis powder drug to the dissolution tank 2 is formed.

A shower 5 similar to the shower 4 is formed above the first dissolving tank 2, and is connected to the water supply means 10 via a line L16. The line L16 is provided with a valve V7, which is opened when the first dissolving tank 2 is washed, and is closed at other times.

A line 15 extending from the intersection of the lines L13 and L14 and connected to the chamber 12 and a line L16 extending from the intersection of the lines L3 and L4 and connected to the chamber 12 are formed. From the chamber 12, a line L17 connected to a dialysate supply device 11 for supplying a dialysate to a patient and a line L18 connected to an opening 1d formed in the side wall of the second dissolution tank 1 extend.

The lines L13, L15, and L1
7, or the lines L6, L3, L16, and L17 constitute a supply line for sending the dialysis stock solution in the second dissolution tank 1 or the first dissolution tank 2 to the dialysis supply device 11.

On the other hand, a line L12 connecting the intersection of the lines L11 and L8 and the intersection of the lines L4 and L5 is formed, and a line L9 extending from the intersection of the lines L13 and L15 to the drain is formed. By opening the valve V6 and the valves V2 and V5 disposed in L12, the dialysis stock solution and the like in the second dissolution tank 1 can be drained. Thus, the lines L13 and L9 or the lines L8, L12, L14, and L9 form a drain line for discharging the liquid in the second dissolving tank 1 or the first dissolving tank 2. A line L7 is formed as another drain line.

The connecting line 6 is used to feed the undiluted dialysis solution exceeding a predetermined level in the first dissolving tank 2 to the second dissolving tank 1, and is formed on the upper side wall of the second dissolving tank 1. Opening 1e
And the opening 2b formed in the upper side wall of the first melting tank 2. That is, when the level of the undiluted dialysis solution that rises due to the supply of water into the first dissolving tank 2 reaches the opening 2b, it overflows and flows into the second dissolving tank 1 via the connection line 6. . Here, since the formation position of the opening 2b is determined, the predetermined liquid level is the position where the opening 2b is formed, and the volume converted from the predetermined liquid level is known.

The calculating means calculates the total volume of the dissolved undiluted dialysis solution from the volume converted from the predetermined liquid level in the first dissolving tank 2 and the liquid level detected by the liquid level detecting means 3. And comprises, for example, a microcomputer. In principle, the volume of the stock solution for dialysis in the first dissolution tank 2 is known, and the sum of the volume of the stock solution for dialysis in the second dissolution tank 1 is the total volume of the stock solution for dialysis. However, in consideration of the volume of the undiluted dialysis solution remaining in the line, it is preferable to add a predetermined value to the above-mentioned added value as the total volume of the dialysis undiluted material.

Next, the operation of the melting apparatus having the above configuration will be described. After one day of dialysis, the dialysis powder drug required for the next day is previously charged into the first dissolution tank 2 (dialysis powder drug input step). Before dialysis is started on the next day, the valves V1 and V2 are opened to open the water supply line, and the pump P is driven, in order to dissolve the dialysis powdered medicine in the first dissolving tank 2 which has been charged the day before. . Then, water is supplied from the water supply means 10 into the first dissolution tank 2 by the action of the pump P. Unless otherwise stated, each valve cannot be opened and remains closed.

In the first dissolving tank 2, the dialysis powder drug is stirred by the water supply to produce a dialysis stock solution, and when the level of the dialysis stock solution rises and reaches the opening 2b, the dialysis stock solution is added. It overflows and flows into the second dissolving tank 1 via the connection line 6. The undiluted dialysis solution that has flowed into the second dissolution tank 1 flows into the water supply line through the line L6, and is again supplied into the first dissolution tank 2 together with water from the water supply means. Thus, the dialysis stock solution circulates between the second dissolution tank 1 and the first lysis tank 2, and gradually becomes a dialysis stock solution having a uniform concentration.

At this time, if the valve V6 is opened, the pump P
A part of the dialysis stock solution circulated by the action of
8 again returns to the second dissolving tank 1 and is stirred.
As described above, since the undiluted dialysis solution returning to the second dissolution tank 1 and the first lysis tank 2 is blown up from the center of the lower surface of each tank, the undiluted undiluted solution having a high concentration that tends to accumulate on the bottom of the tank is stirred. Thus, the concentration of the stock solution for dialysis in the tank is made more uniform.

A part of the undiluted dialysis solution passing through the line L12 is diverted to the line L11 and returned to the second dissolution tank 1 from the side wall of the second dissolution tank 1 through the line L10. The concentration is measured in the concentration cell 8 while the undiluted dialysis solution passes through this line. If the concentration is abnormal, a warning is displayed to the operator by stopping the apparatus or using an operation panel (not shown). But,
In the present embodiment, since the concentration measurement of the undiluted solution for dialysis only needs to detect the volume of the undiluted solution for dialysis, the concentration measurement by the concentration cell 8 is appropriately performed, and the concentration measurement may not be performed. .

When a predetermined amount of the undiluted dialysis solution has accumulated in the second dissolution tank 1, the valve V1 is closed, the water supply line is shut off, and the operation of the pump P is stopped. When the flow into the dissolution tank 1 stops,
The liquid level of the undiluted dialysis solution in the second dissolving tank 1 is detected by the liquid level detecting means 3. Since the liquid level detection is performed by the above-described ultrasonic liquid level sensor 3a or the magnetostrictive displacement sensor 3b, the detection range (in the ultrasonic liquid level sensor 3a, from near the bottom in the second dissolving tank to immediately below the sensor, the magnetostrictive Displacement sensor 3
b, a predetermined range within the magnetostrictive line 3ba), any liquid level can be detected.

The calculating means 9 calculates a second
The total volume of the undiluted solution for dialysis in the dissolution tank 1 and the first dissolution tank 2 is calculated, and the valve V1 is again adjusted until the volume of the entire undiluted solution for dialysis with respect to the charged dialysis powder drug reaches a predetermined concentration.
, And circulating and stirring for a while to complete the dialysis stock solution preparation step. The reason why the water supply is divided into two times is that the whole volume changes when the dialysis powder drug is dissolved in water. That is, since the volume of the dialysis powder drug is dissolved in water and the volume thereof is reduced, the volume of the undiluted dialysis solution is smaller than the volume obtained by adding the dialysis powder drug and the water supply amount.

Further, since the amount of reduction in volume differs depending on the dialysis powder medicine to be dissolved, it is difficult to supply water in anticipation of the amount of reduction in volume. Therefore, water is initially supplied at about 80% to 90% of the target, and after the powder medicine for dialysis is completely dissolved, the liquid level is detected to recognize the amount of water supply to be the target volume. That is.
Such two-time supply of water is similarly performed in a predetermined additional dissolution step and an optional additional dissolution step described later.

In the step of preparing the undiluted solution for dialysis, when the dissolution of the set number of drugs has not been achieved (that is, when the required amount is not sufficient), the following additional dissolution step (hereinafter referred to as the additional dissolution step in this case) In particular, a predetermined additional dissolution step is performed. After the valves V1, V6, and V4 are opened to supply water into the second dissolving tank 1, an additional amount of the dialysis powder medicine is charged into the second dissolving tank 1, and the pump P is driven. It is sufficient to supply the additional amount of the dialysis powder medicine only when water is supplied into the second dissolving tank 1, and it is preferable to display an instruction for the supply to the operator from an operation panel (not shown).

Thus, the water from the water supply means 10 is supplied from the bottom into the second dissolving tank 1 through the lines L1, L2, L3, L4, L12 and L8, and a part of the water is supplied from the line L12. Divide the lines L11 and L10
And is supplied into the second dissolving tank 1 from above.

On the other hand, since the valve V4 is open,
During the predetermined additional dissolution step in the second dissolution tank 1, the stock solution for dialysis is being supplied from the first dissolution tank 2 to the dialysate supply device 11 via the lines L13, L15, and L17. Then, the volume of the stock solution for dialysis in the second dissolving tank 1 is again detected by the liquid level detecting means 3, and a value obtained by subtracting the stock solution for dialysis in the second dissolving tank 1 detected immediately before from this detection value is
When a volume corresponding to the additionally charged dialysis powder drug is reached, the predetermined additional dissolution step is completed.

To perform the dialysis, the stock solution for dialysis in the second dissolving tank 1 is sent to the dialysate supply device 11 by opening the supply line by opening the valve V3 (stock solution supply process for dialysis). Note that the supply line may be opened by opening the valve V <b> 3, and the dialysis stock solution in the first dissolution tank 2 may be sent to the dialysis solution supply device 11. That is, it is possible to appropriately select whether to use the stock solution for dialysis in the second dissolution tank 1 first or to use the stock solution for dialysis in the first dissolution tank 1 first.

When it becomes necessary to additionally prepare a dialysis stock solution during the dialysis stock solution supply step (that is, when the required amount is not enough), the following additional dissolution step (hereinafter, the additional dissolution step in this case is particularly required) Optional dissolution step).
If the stock solution for dialysis required for the time required for the optional additional dissolution step does not remain in the first dissolution tank 2, the stock solution for dialysis in the second dissolution tank 1 is transferred to the first dissolution tank 2 in advance. Need to be kept.

First, the liquid level detecting means 3 causes the second dissolving tank 1
The liquid level of the undiluted dialysis solution remaining inside is detected. At this time,
Since the liquid level in the second dissolving tank 1 is continuously detected by the ultrasonic liquid level sensor 3a or the magnetostrictive displacement sensor 3b, there is no problem that the liquid level cannot be detected, and the detection time is constant at any liquid level. can do. Next, the valves V1, V6, and V4 are opened to supply water into the second dissolving tank 1, and then an additional amount of the dialysis powder drug is charged into the second dissolving tank 1, and the pump P is driven. It is sufficient to supply the additional amount of the dialysis powder medicine only when water is supplied into the second dissolving tank 1, and it is preferable to display an instruction for the supply to the operator from an operation panel (not shown).

Thus, the water from the water supply means 10 is supplied from the bottom into the second dissolving tank 1 through the lines L1, L2, L3, L4, L12 and L8, and a part of the water is supplied from the line L12. Divide the lines L11 and L10
And is supplied into the second dissolving tank 1 from above.

On the other hand, since the valve V4 is open,
During the optional additional dissolution step in the second dissolution tank 1, the undiluted dialysis solution is continuously supplied from the first dissolution tank 2 to the dialysate supply device 11 via the lines L13, L15, and L17. Then, the volume of the stock solution for dialysis in the second dissolving tank 1 is detected again by the liquid level detecting means 3 and a value obtained by subtracting the stock solution for dialysis remaining in the second dissolving tank 1 detected first from this detection value. Ends the optional additional dissolution step when the volume of the dialysis powder has reached the volume corresponding to the additionally charged dialysis powder drug.

In the predetermined additional dissolving step and the optional additional dissolving step, if no dialysis stock solution remains in the second dissolving tank 1 (when the second dissolving tank 1 is empty), before or after water supply. It is preferable to sometimes open the valve V8 to drain the undiluted dialysis solution remaining in the line.

Next, the step of cleaning and disinfecting the second dissolving tank 1 and the first dissolving tank 2 will be described. The washing in the first dissolving tank 2 is performed in a state in which the undiluted dialysis solution remains in the first dissolving tank 2 (when the undiluted dialysis solution is used, and when the valve V5 is opened, the drain line is opened to release the undiluted dialysis solution. This is performed during the supply of the stock solution for dialysis by the second dissolving tank 2.

That is, the valve V7 is opened and the water of the water supply means 10 is sprinkled in the first dissolving tank 2 with the shower 5 for washing, and the valve V3 is opened to release the supply line and the second dissolving tank 1 is opened. The stock solution for dialysis is supplied to the dialysate supply device 11. Incidentally, the valve V6 is opened to release the line reaching the supply line via the lines L12 and L4, and the dialysis stock solution in the second dissolution tank 1 is also supplied to the dialysis supply device 11 by this line. The water sprinkled from the shower 5 is drained by the drain line opened by opening the valve V5.

The washing in the second dissolving tank 1 is performed after one day of dialysis is completed, and is performed in a state in which the dialysis powder drug required for the next day of dialysis is charged into the first dissolving tank 2. . That is,
The valve V2 is opened and the water of the water supply means 10 is sprinkled and washed in the first dissolution tank 2 by the shower 4 while the pump P
Is driven to circulate the water used for washing in the second dissolving tank 1. This circulation can also clean the line through which the circulating water flows. In addition, the valve V6 may be opened as needed at the time of cleaning, and the line including the line L12 may be cleaned.

Also, a disinfecting solution is introduced into the disinfecting unit 7,
By flowing this disinfecting solution into the second dissolving tank 1, disinfection in the second dissolving tank 1 can also be performed. This disinfection is preferably performed between a plurality of cleanings to avoid residual disinfectant. Further, by opening the valve V3 and driving the pump P, the lines L6, L3, L16, and L
The water in the second dissolving tank 1 is circulated in the line formed by 18 to clean the chamber 12. If such a line is formed during the disinfection of the second dissolving tank 1, the chamber can be disinfected. The water after cleaning or disinfection is supplied to the valve V
The valve 5 is discharged by opening the valve 5 so that water for disinfection does not mix with the powdered dialysis agent in the first dissolving tank 2.
It is preferable to carry out cleaning or disinfection with the device opened.

According to the first embodiment, since there are two dissolving tanks consisting of the second dissolving tank 1 and the first dissolving tank 2, dialysis is performed even during the additional dissolving step (including both the default and optional steps). Since the stock solution for dialysis can be continuously supplied to the solution supply device 11 and the liquid level detecting means 3 can continuously detect the liquid level of the stock solution for dialysis, the liquid level is detected stepwise. As compared with the above, the additional dissolving operation of the stock solution for dialysis can be facilitated.

Next, a second embodiment according to the present invention will be described. As shown in FIG. 4, the dissolving apparatus according to the present embodiment includes one dissolving tank 13, a stirrer 14, a shower 15, a liquid level detecting unit 3, an arithmetic unit 9, a water supply unit 10, a plurality of valves, V9 to V12, a dialysate supply device 11, and lines L19 to L24. In addition, about the same component as 1st Embodiment,
The same reference numerals are given.

From the water supply means 10, lines L19 and L2
1 is extended and connected to the bottom of the melting tank 13,
A water supply valve V10 is provided on the line L21. From the intersection of lines L19 and L21, line L2
0 is extended and connected to a shower 15 disposed above the melting tank 13. The water supply line is formed by the lines L19 and L21.

On the other hand, from the bottom of the melting tank 13, a line L
22 and L23 are extended, and a drain valve V11 is provided in the line L23. These lines L22 and L23 form a drain line. Also,
A line L24 extends from the intersection of the lines L22 and L23 and is connected to the dialysate supply device 11.

The stirrer 14 is, for example, an impeller disposed on the bottom surface in the dissolving tank 13. The impeller rotates to stir the dialysis stock solution contained in the dissolving tank 13. It is configured. In addition, stirrer 1
4 is not limited to the impeller, and may be replaced with one having another stirring function.

The liquid level detecting means 3 is the same as that in the first embodiment, and comprises, for example, an ultrasonic liquid level sensor 3a or a magnetostrictive displacement sensor 3b. To perform the dialysis stock solution preparation process,
After a predetermined amount of the dialysis powder drug is charged, the valve V10 is opened to release the water supply line and to drive the agitator 14. After the water supply line is released first, a predetermined amount of the dialysis powder medicine may be charged, and a predetermined amount of the dialysis powder medicine is administered in advance on the day before dialysis, and the water supply line is opened on the day of dialysis. The water may be supplied.

When a predetermined amount of the undiluted dialysis solution has accumulated in the dissolution tank 13, the valve 10 is closed to shut off the water supply line and stop driving the agitator 14 to detect the level of the undiluted dialysis solution. Then, the valve V10 is opened again until the total volume of the dialysis stock solution reaches a predetermined concentration with respect to the charged dialysis powder drug, and the stirring operation by the stirrer 14 is performed for a while to complete the dissolution process of the stock solution. The reason for dividing the water supply into two times as described above has been described in the first embodiment, and will not be described. To perform the dialysis stock solution supply step, the valve V1
2 is opened and the stock solution for dialysis in the dissolving tank 13 is sent to the dialysate supply device 11.

If it is necessary to add a stock solution for dialysis due to an increase in the number of patients or an error in calculating the volume of the stock solution for dialysis to be dissolved, etc. The following additional dissolution step is performed at times between the morning dialysis time) and the like. First, the supply of the undiluted dialysis solution to the dialysis fluid supply device 11 is stopped by closing the valve V12, and then the level of the remaining undiluted dialysis solution is detected by the liquid level detecting means 3.
After the detection of the liquid level, the valve 10 is opened to supply water into the dissolution tank 13, and an additional dialysis powder drug is charged and stirred by the stirrer 14. The feeding of the dialysis powder medicine may be performed during the supply of water, and it is preferable that the operator instructs the operator to input the dialysis powder by, for example, an operation panel (not shown).

Then, the volume of the stock solution for dialysis in the dissolving tank 13 is detected again by the liquid level detecting means 3, and the volume of the stock solution for dialysis remaining in the dissolving tank 13 is calculated by the calculating means 9 from the detected value. The additional dissolution step is terminated when the value obtained by the subtraction becomes a volume corresponding to the added powdered dialysis powder.

As in the first embodiment, in the additional dissolving step, when no dialysis stock solution remains in the dissolving tank 13 (when the dissolving tank 13 is empty), the valve is supplied before or during water supply. It is preferable to open V11 and drain the dialysis stock solution remaining in the line.

To clean the inside of the dissolving tank 13, the valve V9
Is opened and water is sprayed in the dissolving tank 13 by the shower 15, and the drainage after washing is performed by opening the valve V11. Further, a disinfection unit similar to that of the first embodiment may be provided in the dissolving tank 13 to perform disinfection.

According to the second embodiment, one dissolving tank is used.
Therefore, the size of the entire apparatus can be reduced, and the additional dissolving operation can be facilitated by the liquid level detecting means capable of continuously detecting the liquid level.

The lysing apparatus according to the first and second embodiments has been described above. The dialysis stock solution preparation step, the additional lysis step (including the default additional lysis step and the optional additional lysis step), and the dialysis The stock solution supply step and the cleaning / disinfecting step may be switched manually, or the steps may be automatically switched by sequence control or the like.

[0064]

According to the first aspect of the present invention, the level of the undiluted dialysis solution in the dissolving tank can be continuously detected. The additional dissolving operation of the stock solution can be facilitated, and the maintenance operation can be reduced. According to the second aspect of the present invention, since the additional dissolution operation is performed by the two dissolution tanks provided in parallel, in addition to the effect of the first aspect, it is possible to supply the dialysis stock solution to the dialysate supply device even during the additional dissolution. it can. According to the third aspect of the invention, it is possible to facilitate the additional dissolving operation of the dialysis stock solution.

[Brief description of the drawings]

FIG. 1 is a schematic system diagram of a melting apparatus according to a first embodiment of the present invention.

FIG. 2 is a schematic diagram showing an ultrasonic liquid level sensor as a liquid level detecting means of the melting apparatus according to the present invention.

FIG. 3 is a schematic diagram showing a magnetostrictive displacement sensor as a liquid level detecting means of the melting apparatus according to the present invention.

FIG. 4 is a schematic system diagram of a melting apparatus according to a second embodiment of the present invention.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 ... 2nd dissolution tank 1a-1e ... opening 2 ... 1st dissolution tank 2a, 2b ... opening 3 ... Liquid level detection means 3a ... Ultrasonic liquid level sensor (liquid level detection means) 3b ... Magnetostrictive displacement sensor (liquid level detection) Means) 4,5 Shower 6 Connection line 7 Disinfection unit 8 Concentration cell 9 Calculation means 10 Water supply means 11 Dialysate supply device 12 Chamber 13 Dissolution tank 14 Stirrer F1 Filters L1 to L24 Line V1-V12… Valve P… Pump

 ──────────────────────────────────────────────────続 き Continued on the front page F term (reference) 4C077 AA05 BB01 DD01 DD12 DD17 DD26 EE03 HH02 HH20 JJ04 JJ16 KK25 4G035 AA19 AE13 4G037 BA05 BC03 BD06

Claims (3)

[Claims] 1. A dissolving apparatus for dissolving a dialysis powder drug to obtain a dialysis stock solution, comprising: a dissolution tank for containing the dialysis stock solution; and water for dissolving the dialysis powder drug in the dissolution tank. A water supply line, a liquid level detection means capable of continuously detecting a liquid level of the undiluted solution for dialysis dissolved and generated by the water supply line, and a dialysis in the dissolving tank based on the liquid level detected by the liquid level detection means. A dissolving apparatus comprising: a calculating means for calculating a volume of a stock solution; and a supply line for supplying the stock solution from the dissolving tank to a dialysate supply device. 2. The dissolving tank comprises a first dissolving tank and a second dissolving tank provided side by side, and wherein the dialysis solution, which has been generated by supplying water into the first dissolving tank, has exceeded a predetermined level. A connecting line for flowing the undiluted dialysis solution into the second dissolving tank, wherein the undiluted dialysis solution flowing out of the connection line is detected by the liquid level detecting means, and the arithmetic means is detected by the liquid level detecting means. The total volume of the dissolved dialysis stock solution is calculated from a volume calculated from the obtained liquid level and a volume converted from a predetermined liquid level in the first dissolving tank. Melting equipment. 3. The liquid level detecting means detects the liquid level of the undiluted dialysis solution in the dissolving tank and calculates the volume by the calculating means. And after addition, the liquid level detecting means again detects the liquid level of the undiluted dialysis solution in the dissolving tank and calculates the volume by the calculating means, and the dialysis after adding the dialysis powder drug. 2. The method according to claim 1, wherein the volume of the undiluted undiluted solution is calculated by subtracting the volume of the undiluted undiluted solution from the volume of the undiluted solution.