JO3029B1 - مشتقات مبتكرة مضادة للفطريات ل 5 ، 6 - ثاني هيدرو - 4- [(ثاني فلورو اثيل) فينيل] -4 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبين و 4- ( ثاني فلورو اثيل ) فينيل - 6 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبين - Google Patents
مشتقات مبتكرة مضادة للفطريات ل 5 ، 6 - ثاني هيدرو - 4- [(ثاني فلورو اثيل) فينيل] -4 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبين و 4- ( ثاني فلورو اثيل ) فينيل - 6 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبينInfo
- Publication number
- JO3029B1 JO3029B1 JOP/2011/0174A JOP20110174A JO3029B1 JO 3029 B1 JO3029 B1 JO 3029B1 JO P20110174 A JOP20110174 A JO P20110174A JO 3029 B1 JO3029 B1 JO 3029B1
- Authority
- JO
- Jordan
- Prior art keywords
- dichloroethyl
- benzodiazepine
- phenyl
- pirolo
- pyrrolo
- Prior art date
Links
- GUJAGMICFDYKNR-UHFFFAOYSA-N 1,4-benzodiazepine Chemical compound N1C=CN=CC2=CC=CC=C12 GUJAGMICFDYKNR-UHFFFAOYSA-N 0.000 title 2
- -1 4- (dichloroethyl) phenyl Chemical group 0.000 title 1
- 230000000843 anti-fungal effect Effects 0.000 title 1
- 229940121375 antifungal agent Drugs 0.000 title 1
- 125000006003 dichloroethyl group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 241001480043 Arthrodermataceae Species 0.000 abstract 1
- 206010017533 Fungal infection Diseases 0.000 abstract 1
- 208000031888 Mycoses Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000037304 dermatophytes Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
- A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
يتعلق الاختراع الحالي بمركبات (compounds) جديدة من الصيغة (I): حيث يكون R1، R2، R3، R4، R5 وR6 لهم المعاني المحددة في عناصر الحماية. إن المركبات طبقا للاختراع الحالي نشطة أساسيا ضد الفطريات الجلدية والإصابات بعدوى فطرية شاملة. يتعلق الاختراع إضافيا بعمليات (processes) لتحضير هذه المركبات (compounds) الجديدة، بتركيبات دوائية (pharmaceutical compositions) تشتمل على المركبات (compounds) المذكورة كمقوم نشط (active ingredient) بالإضافة إلى استخدام المركبات (compounds) المذكورة كدواء (medicament).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10165076 | 2010-06-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3029B1 true JO3029B1 (ar) | 2016-09-05 |
Family
ID=42294978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2011/0174A JO3029B1 (ar) | 2010-06-07 | 2011-05-30 | مشتقات مبتكرة مضادة للفطريات ل 5 ، 6 - ثاني هيدرو - 4- [(ثاني فلورو اثيل) فينيل] -4 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبين و 4- ( ثاني فلورو اثيل ) فينيل - 6 H - بيرولو [2،1 -a ] [1،4] بينزوديازيبين |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9637490B2 (ar) |
| EP (1) | EP2576557B1 (ar) |
| JP (4) | JP5922107B2 (ar) |
| KR (1) | KR101886136B1 (ar) |
| CN (1) | CN102947307B (ar) |
| AP (1) | AP3285A (ar) |
| AR (1) | AR081642A1 (ar) |
| AU (1) | AU2011263946B2 (ar) |
| BR (1) | BR112012030895A2 (ar) |
| CA (1) | CA2799634C (ar) |
| EA (1) | EA021220B1 (ar) |
| ES (1) | ES2489191T3 (ar) |
| HK (1) | HK1178152A1 (ar) |
| JO (1) | JO3029B1 (ar) |
| MX (1) | MX2012014271A (ar) |
| MY (1) | MY156731A (ar) |
| NZ (1) | NZ602981A (ar) |
| PH (1) | PH12012502293A1 (ar) |
| SG (1) | SG185650A1 (ar) |
| TW (1) | TWI500619B (ar) |
| UA (1) | UA107963C2 (ar) |
| WO (1) | WO2011154298A1 (ar) |
| ZA (1) | ZA201209246B (ar) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ587490A (en) * | 2010-08-20 | 2013-03-28 | Greentide Ltd | Anti-Microbial Compounds containing compounds with a sugar substituent |
| BR112013012547A2 (pt) * | 2010-11-24 | 2016-08-09 | Janssen Pharmaceutica Nv | antifúngicos 5,6-di-hidro-4h-pirrolo][1,4]benzodiazepinas e 6h-pirrolo [1,2-a] [1,4]benzodiazepinas substituídos por derivados de fenila |
| AU2013204604B2 (en) * | 2012-05-30 | 2016-05-19 | Biodiem Limited | Method of treating Scedosporium spp. infection |
| JP6197348B2 (ja) * | 2013-04-25 | 2017-09-20 | セントラル硝子株式会社 | α，α−ジフルオロ芳香族化合物の保存安定性の向上方法 |
| RU2771019C1 (ru) * | 2021-06-29 | 2022-04-25 | Федеральное государственное автономное образовательное учреждение высшего образования "Пермский государственный национальный исследовательский университет" (ПГНИУ) | Применение 10-метил-2-(трифторметил)-6,7-дигидро-5Н-бензо[b]пирроло[1,2-d][1,4]диазепина в качестве антибактериального средства в отношении грамположительных микроорганизмов |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1392691B1 (en) * | 2000-10-23 | 2009-05-20 | Janssen Pharmaceutica N.V. | Antifungal 4-substituted 5,6-dihydro-4h-pyrrolo[1,2-a] [1,4] benzodiazepines |
-
2011
- 2011-01-06 UA UAA201211701A patent/UA107963C2/uk unknown
- 2011-05-30 JO JOP/2011/0174A patent/JO3029B1/ar active
- 2011-06-01 CN CN201180028301.XA patent/CN102947307B/zh active Active
- 2011-06-01 JP JP2013513625A patent/JP5922107B2/ja active Active
- 2011-06-01 SG SG2012084901A patent/SG185650A1/en unknown
- 2011-06-01 CA CA2799634A patent/CA2799634C/en active Active
- 2011-06-01 MY MYPI2012005016A patent/MY156731A/en unknown
- 2011-06-01 PH PH1/2012/502293A patent/PH12012502293A1/en unknown
- 2011-06-01 NZ NZ602981A patent/NZ602981A/xx not_active IP Right Cessation
- 2011-06-01 KR KR1020127030661A patent/KR101886136B1/ko active Active
- 2011-06-01 BR BR112012030895A patent/BR112012030895A2/pt not_active Application Discontinuation
- 2011-06-01 EP EP11723445.0A patent/EP2576557B1/en active Active
- 2011-06-01 AP AP2012006502A patent/AP3285A/xx active
- 2011-06-01 US US13/702,361 patent/US9637490B2/en active Active
- 2011-06-01 AU AU2011263946A patent/AU2011263946B2/en not_active Ceased
- 2011-06-01 MX MX2012014271A patent/MX2012014271A/es active IP Right Grant
- 2011-06-01 ES ES11723445.0T patent/ES2489191T3/es active Active
- 2011-06-01 WO PCT/EP2011/059058 patent/WO2011154298A1/en active Application Filing
- 2011-06-01 EA EA201291401A patent/EA021220B1/ru not_active IP Right Cessation
- 2011-06-03 TW TW100119491A patent/TWI500619B/zh not_active IP Right Cessation
- 2011-06-06 AR ARP110101951A patent/AR081642A1/es unknown
-
2012
- 2012-12-06 ZA ZA2012/09246A patent/ZA201209246B/en unknown
-
2013
- 2013-04-26 HK HK13105094.9A patent/HK1178152A1/xx not_active IP Right Cessation
-
2016
- 2016-01-13 JP JP2016004295A patent/JP6208263B2/ja active Active
-
2017
- 2017-09-06 JP JP2017170727A patent/JP6505176B2/ja active Active
-
2019
- 2019-03-26 JP JP2019057689A patent/JP6653036B2/ja active Active
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