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IT1307928B1 - Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. - Google Patents

Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Info

Publication number
IT1307928B1
IT1307928B1 IT1999MI000134A ITMI990134A IT1307928B1 IT 1307928 B1 IT1307928 B1 IT 1307928B1 IT 1999MI000134 A IT1999MI000134 A IT 1999MI000134A IT MI990134 A ITMI990134 A IT MI990134A IT 1307928 B1 IT1307928 B1 IT 1307928B1
Authority
IT
Italy
Prior art keywords
synthesis
derivatives
aspirine
nitroxymethylphenyl
esters
Prior art date
Application number
IT1999MI000134A
Other languages
English (en)
Inventor
Soldato Piero Del
Michele Garufi
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to IT1999MI000134A priority Critical patent/IT1307928B1/it
Application filed by Nicox Sa filed Critical Nicox Sa
Priority to AU26645/00A priority patent/AU766497B2/en
Priority to SI200030689T priority patent/SI1147074T1/xx
Priority to CNB008051801A priority patent/CN1191228C/zh
Priority to CA002361454A priority patent/CA2361454A1/en
Priority to US09/868,932 priority patent/US6512137B1/en
Priority to DK00904925T priority patent/DK1147074T3/da
Priority to PT00904925T priority patent/PT1147074E/pt
Priority to RU2001120697/04A priority patent/RU2232747C2/ru
Priority to JP2000595962A priority patent/JP2002535380A/ja
Priority to CNA2004100636418A priority patent/CN1572787A/zh
Priority to EP00904925A priority patent/EP1147074B1/en
Priority to ES00904925T priority patent/ES2239588T3/es
Priority to AT00904925T priority patent/ATE291567T1/de
Priority to DE60018902T priority patent/DE60018902T2/de
Priority to KR1020017009285A priority patent/KR100732147B1/ko
Priority to IL14423400A priority patent/IL144234A0/xx
Priority to PCT/EP2000/000353 priority patent/WO2000044705A1/en
Priority to BR0007643-0A priority patent/BR0007643A/pt
Priority to HU0105011A priority patent/HUP0105011A3/hu
Publication of ITMI990134A1 publication Critical patent/ITMI990134A1/it
Priority to ZA200105705A priority patent/ZA200105705B/en
Application granted granted Critical
Publication of IT1307928B1 publication Critical patent/IT1307928B1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/86—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with esterified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
    • C07C201/02—Preparation of esters of nitric acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)
IT1999MI000134A 1999-01-26 1999-01-26 Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina. IT1307928B1 (it)

Priority Applications (21)

Application Number Priority Date Filing Date Title
IT1999MI000134A IT1307928B1 (it) 1999-01-26 1999-01-26 Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.
EP00904925A EP1147074B1 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
CNB008051801A CN1191228C (zh) 1999-01-26 2000-01-18 阿司匹林衍生物的硝酰基甲基苯基酯的合成方法
CA002361454A CA2361454A1 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
US09/868,932 US6512137B1 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
DK00904925T DK1147074T3 (da) 1999-01-26 2000-01-18 Fremgangsmåde til fremstilling af nitroxymethylphenylestere af aspirinderivater
PT00904925T PT1147074E (pt) 1999-01-26 2000-01-18 Metodo de sintese de esteres nitroximetilfenilicos de derivados do acido acetilsalicilico
AT00904925T ATE291567T1 (de) 1999-01-26 2000-01-18 Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten
SI200030689T SI1147074T1 (it) 1999-01-26 2000-01-18
CNA2004100636418A CN1572787A (zh) 1999-01-26 2000-01-18 阿司匹林衍生物的硝酰基甲基苯基酯的合成方法
AU26645/00A AU766497B2 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
JP2000595962A JP2002535380A (ja) 1999-01-26 2000-01-18 アスピリン誘導体のニトロキシメチルフェニルエステルの合成方法
RU2001120697/04A RU2232747C2 (ru) 1999-01-26 2000-01-18 Способ синтеза нитроксиметилфениловых эфиров аспирина и его производных
DE60018902T DE60018902T2 (de) 1999-01-26 2000-01-18 Verfahren zur herstellung von nitroxymethylphenylestern von aspirinderivaten
KR1020017009285A KR100732147B1 (ko) 1999-01-26 2000-01-18 아스피린유도체의 니트록시메틸페닐 에스테르의 합성방법
IL14423400A IL144234A0 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
PCT/EP2000/000353 WO2000044705A1 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
BR0007643-0A BR0007643A (pt) 1999-01-26 2000-01-18 Processo para obter ésteres de (nitroximetil) fenila de derivados de aspirina, e, (hidroximetil) feniléter de derivados de aspirina
HU0105011A HUP0105011A3 (en) 1999-01-26 2000-01-18 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives
ES00904925T ES2239588T3 (es) 1999-01-26 2000-01-18 Sintesis de esteres de nitroximetilfenilo-esteres de derivados de la aspirina.
ZA200105705A ZA200105705B (en) 1999-01-26 2001-07-11 Synthesis method of nitroxymethylphenyl esters of aspirin derivatives.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000134A IT1307928B1 (it) 1999-01-26 1999-01-26 Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Publications (2)

Publication Number Publication Date
ITMI990134A1 ITMI990134A1 (it) 2000-07-26
IT1307928B1 true IT1307928B1 (it) 2001-11-29

Family

ID=11381613

Family Applications (1)

Application Number Title Priority Date Filing Date
IT1999MI000134A IT1307928B1 (it) 1999-01-26 1999-01-26 Metodo di sintesi di nitrossimetilfenil esteri di derivatidell'aspirina.

Country Status (18)

Country Link
US (1) US6512137B1 (it)
EP (1) EP1147074B1 (it)
JP (1) JP2002535380A (it)
KR (1) KR100732147B1 (it)
CN (2) CN1191228C (it)
AT (1) ATE291567T1 (it)
AU (1) AU766497B2 (it)
BR (1) BR0007643A (it)
CA (1) CA2361454A1 (it)
DE (1) DE60018902T2 (it)
ES (1) ES2239588T3 (it)
HU (1) HUP0105011A3 (it)
IL (1) IL144234A0 (it)
IT (1) IT1307928B1 (it)
PT (1) PT1147074E (it)
RU (1) RU2232747C2 (it)
WO (1) WO2000044705A1 (it)
ZA (1) ZA200105705B (it)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU763000B2 (en) 1998-10-30 2003-07-10 Nicox S.A. Nitrosated and nitrosylated nonsteroidal antiinflammatory compounds, compositions and methods of use
IT1312115B1 (it) 1999-06-24 2002-04-04 Nicox Sa Composti amorfi e relative composizioni farmaceutiche
ITMI991517A1 (it) * 1999-07-09 2001-01-09 Nicox Sa Procedimento per ottenere nitrossimetil fenil esterni di derivati dell'acido salicilico
CN100486573C (zh) 1999-12-23 2009-05-13 硝化医药股份有限公司 硝基化的和亚硝基化的环加氧酶-2抑制剂、组合物及其用途
IT1319202B1 (it) 2000-10-12 2003-09-26 Nicox Sa Farmaci per le malattie a base infiammatoria.
DE60122939T2 (de) 2000-12-21 2007-01-11 Nitromed, Inc., Bedford Substituierte arylverbindungen als neue, cyclooxygenase-2-selektive inhibitoren, zusammensetzungen und verwendungsverfahren
ITMI20011308A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per il dolore cronico
ITMI20011307A1 (it) * 2001-06-21 2002-12-21 Nicox Sa Farmaci per l'epilessia
CA2487414A1 (en) 2002-06-11 2003-12-18 Nitromed, Inc. Nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use
AU2003279622A1 (en) 2002-06-28 2004-01-19 Nitromed, Inc. Oxime and/or hydrazone containing nitrosated and/or nitrosylated cyclooxigenase-2 selective inhibitors, compositions and methods of use
AU2003247792B2 (en) 2002-07-03 2009-09-24 Nicox S.A. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
JP2005538110A (ja) 2002-07-29 2005-12-15 ニトロメッド インコーポレーティッド シクロオキシゲナーゼ−２選択的阻害剤、組成物、および使用方法
DE602004014822D1 (de) * 2003-11-20 2008-08-14 Nicox Sa Neues verfahren zur herstellung von nitrooxyderivaten von paracetamol
EP1709155B1 (en) * 2003-12-31 2013-10-02 Chesterford Enterprises Limited Compounds and compositions for treating dysproliferative diseases, and methods of use thereof
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
BRPI0515218A (pt) 2004-08-26 2008-07-08 Nicholas Piramal India Ltd composto, composição farmacêutica, método para o tratamento de um mamìfero ou ser humano, método de uso do composto, novos intermediários, uso dos novos intermediários, processo para a preparação de um composto
JP2007275193A (ja) * 2006-04-04 2007-10-25 Fujifilm Corp 光プローブおよび光断層画像化装置
WO2009023631A1 (en) 2007-08-10 2009-02-19 Basil Rigas Anti-inflammatory compounds and uses thereof
ES2362894B1 (es) * 2009-11-16 2012-05-21 Ferrer Internacional S.A. Procedimiento de preparación del �?cido 4-nitro-oxi-metil-benzoico.
US20140315834A1 (en) * 2012-09-21 2014-10-23 Medicon Pharmaceuticals, Inc. Compounds and compositions for use in the prevention and treatment of inflammation-related disorders, pain and fever, skin disorders, cancer and precancerous conditions thereof
WO2014052889A1 (en) * 2012-09-27 2014-04-03 The Board Of Trustees Of The University Of Illinois Anti-inflammatory agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1243367B (it) * 1990-07-26 1994-06-10 Italfarmaco Spa Derivati acidi benzoici sostituiti ad attivita' cardiovascolare
IT1276071B1 (it) * 1995-10-31 1997-10-24 Nicox Ltd Compositi ad attivita' anti-infiammatoria
SV1997000108A (es) * 1997-12-18 1999-11-24 Manufacturas Humberto Bukele E Sintesis de acido acetilsalicilico en presencia de oxido de calcio

Also Published As

Publication number Publication date
DE60018902D1 (de) 2005-04-28
CN1572787A (zh) 2005-02-02
AU766497B2 (en) 2003-10-16
US6512137B1 (en) 2003-01-28
BR0007643A (pt) 2001-10-16
CA2361454A1 (en) 2000-08-03
KR100732147B1 (ko) 2007-06-25
CN1344244A (zh) 2002-04-10
IL144234A0 (en) 2002-05-23
ITMI990134A1 (it) 2000-07-26
RU2232747C2 (ru) 2004-07-20
ES2239588T3 (es) 2005-10-01
JP2002535380A (ja) 2002-10-22
KR20010101653A (ko) 2001-11-14
HUP0105011A2 (hu) 2002-04-29
ZA200105705B (en) 2002-10-11
HUP0105011A3 (en) 2002-12-28
EP1147074B1 (en) 2005-03-23
ATE291567T1 (de) 2005-04-15
CN1191228C (zh) 2005-03-02
WO2000044705A1 (en) 2000-08-03
EP1147074A1 (en) 2001-10-24
AU2664500A (en) 2000-08-18
DE60018902T2 (de) 2006-03-30
PT1147074E (pt) 2005-07-29

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