IT1277425B1 - Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina - Google Patents
Metodo per la preparazione della 1-b-d-arabinofuranosilcitosinaInfo
- Publication number
- IT1277425B1 IT1277425B1 IT95MI001715A ITMI951715A IT1277425B1 IT 1277425 B1 IT1277425 B1 IT 1277425B1 IT 95MI001715 A IT95MI001715 A IT 95MI001715A IT MI951715 A ITMI951715 A IT MI951715A IT 1277425 B1 IT1277425 B1 IT 1277425B1
- Authority
- IT
- Italy
- Prior art keywords
- ara
- beta
- arabinofuranosilcitosina
- preparation
- arabinofuranosyluracyl
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 abstract 2
- FFUAGWLWBBFQJT-UHFFFAOYSA-N hexamethyldisilazane Chemical compound C[Si](C)(C)N[Si](C)(C)C FFUAGWLWBBFQJT-UHFFFAOYSA-N 0.000 abstract 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 1
- DRTQHJPVMGBUCF-CCXZUQQUSA-N arauridine Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-CCXZUQQUSA-N 0.000 abstract 1
- 229960000684 cytarabine Drugs 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI001715A IT1277425B1 (it) | 1995-08-03 | 1995-08-03 | Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina |
| EP96111996A EP0757056B1 (en) | 1995-08-03 | 1996-07-25 | Method for preparing 1-beta-D-arabinofuranosylcytosine |
| AT96111996T ATE173270T1 (de) | 1995-08-03 | 1996-07-25 | Verfahren zur herstellung von 1-beta-d- arabinofuranosylcytosine |
| ES96111996T ES2126971T3 (es) | 1995-08-03 | 1996-07-25 | Metodo para preparar 1-beta-d-arabinofuranosilcitosina. |
| DE69600958T DE69600958T2 (de) | 1995-08-03 | 1996-07-25 | Verfahren zur Herstellung von 1-Beta-D-Arabinofuranosylcytosine |
| JP8231219A JPH09165396A (ja) | 1995-08-03 | 1996-07-30 | １−β−Ｄ−アラビノフラノシルシトシンの製造方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT95MI001715A IT1277425B1 (it) | 1995-08-03 | 1995-08-03 | Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITMI951715A0 ITMI951715A0 (it) | 1995-08-03 |
| ITMI951715A1 ITMI951715A1 (it) | 1997-02-03 |
| IT1277425B1 true IT1277425B1 (it) | 1997-11-10 |
Family
ID=11372129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT95MI001715A IT1277425B1 (it) | 1995-08-03 | 1995-08-03 | Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP0757056B1 (it) |
| JP (1) | JPH09165396A (it) |
| AT (1) | ATE173270T1 (it) |
| DE (1) | DE69600958T2 (it) |
| ES (1) | ES2126971T3 (it) |
| IT (1) | IT1277425B1 (it) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302004C (zh) * | 2003-08-22 | 2007-02-28 | 浙江海正药业股份有限公司 | 一种阿糖胞苷的制备方法 |
| CN101948492A (zh) * | 2010-08-20 | 2011-01-19 | 河南师范大学 | 化学合成法生产阿糖胞苷的工艺 |
| CN112552361A (zh) * | 2020-12-30 | 2021-03-26 | 瀚晖制药有限公司 | 阿糖胞苷晶体、阿糖胞苷冻干粉剂及冻干方法 |
| CN113292611B (zh) * | 2021-06-25 | 2022-05-17 | 国药一心制药有限公司 | 一种阿糖胞苷的纯化方法 |
| CN113735926B (zh) * | 2021-09-14 | 2023-07-25 | 江苏香地化学有限公司 | 一种尿苷的合成工艺 |
| CN117164646A (zh) * | 2023-11-03 | 2023-12-05 | 广州市桐晖药业有限公司 | 一种阿糖胞苷的合成方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3116282A (en) | 1960-04-27 | 1963-12-31 | Upjohn Co | Pyrimidine nucleosides and process |
| US3658788A (en) | 1969-06-06 | 1972-04-25 | Salk Inst For Biological Studi | Aminooxazolines and products thereof and processes for synthesizing same |
| US3721664A (en) | 1970-01-27 | 1973-03-20 | Hoffmann La Roche | Preparation of 5-cytosine nucleosides |
| US3868373A (en) | 1970-01-27 | 1975-02-25 | Hoffmann La Roche | 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines |
| JPS5010595B1 (it) | 1970-09-18 | 1975-04-22 | ||
| US3978042A (en) | 1975-01-31 | 1976-08-31 | The Upjohn Company | Process for preparing cyclocytidine derivatives |
| US4754026A (en) | 1985-06-04 | 1988-06-28 | Takeda Chemical Industries, Ltd. | Conversion of uracil derivatives to cytosine derivatives |
| JPH07103149B2 (ja) | 1987-11-30 | 1995-11-08 | ヤマサ醤油株式会社 | シトシン誘導体の製造法 |
| BR9106158A (pt) | 1990-03-13 | 1993-03-16 | Acic Canada Inc | Processo para produzir 2,2'-o-ciclonucleosideos,nucleosideos e seus analogos |
-
1995
- 1995-08-03 IT IT95MI001715A patent/IT1277425B1/it active IP Right Grant
-
1996
- 1996-07-25 EP EP96111996A patent/EP0757056B1/en not_active Expired - Lifetime
- 1996-07-25 AT AT96111996T patent/ATE173270T1/de not_active IP Right Cessation
- 1996-07-25 ES ES96111996T patent/ES2126971T3/es not_active Expired - Lifetime
- 1996-07-25 DE DE69600958T patent/DE69600958T2/de not_active Expired - Fee Related
- 1996-07-30 JP JP8231219A patent/JPH09165396A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2126971T3 (es) | 1999-04-01 |
| DE69600958T2 (de) | 1999-06-10 |
| JPH09165396A (ja) | 1997-06-24 |
| ITMI951715A1 (it) | 1997-02-03 |
| ATE173270T1 (de) | 1998-11-15 |
| ITMI951715A0 (it) | 1995-08-03 |
| EP0757056B1 (en) | 1998-11-11 |
| DE69600958D1 (de) | 1998-12-17 |
| EP0757056A1 (en) | 1997-02-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |