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ES2126971T3 - Metodo para preparar 1-beta-d-arabinofuranosilcitosina. - Google Patents

Metodo para preparar 1-beta-d-arabinofuranosilcitosina.

Info

Publication number
ES2126971T3
ES2126971T3 ES96111996T ES96111996T ES2126971T3 ES 2126971 T3 ES2126971 T3 ES 2126971T3 ES 96111996 T ES96111996 T ES 96111996T ES 96111996 T ES96111996 T ES 96111996T ES 2126971 T3 ES2126971 T3 ES 2126971T3
Authority
ES
Spain
Prior art keywords
sub
arabinofuranosilcitosine
beta
preparing
parabinofuranosiluracilo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES96111996T
Other languages
English (en)
Inventor
Meglio Giuseppe De
Giancarlo Ordanini
Tiberio Bruzzese
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pro Bio Sint Srl
Original Assignee
Pro Bio Sint Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pro Bio Sint Srl filed Critical Pro Bio Sint Srl
Application granted granted Critical
Publication of ES2126971T3 publication Critical patent/ES2126971T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE DESCRIBE UN NUEVO PROCESO PPARA FABRICAR EL DERIVADO NUCLEOSIDICO 1-{B}-D-PARABINOFURANOSILCITOSINA (CITPARABINA, PARAC), SEGUN EL CUAL SE TRATA EL 1-{B}-D-PARABINOFURANOSILURACILO (PARA-U), BAJO PRESION REDUCIDA Y BAJO CALENTAMIENTO, CON HEXAMETILDISILAZANO Y UN C{SUB,1}-C{SUB,3} ACILAMIDA. DESPUES DE EVAPORAR EL SOLVENTE Y EL TRATAMIENTO CON ALCOHOL DE METILO Y AMONIACO ACUOSO, LA MEZCLA DE REACCION ES SOMETIDA A PURIFICACION SOBRE UNA RESINA ACIDA, OBTENIENDOSE POR ELLO EL PRODUCTO PERTINENTE EN GRANDES CANTIDADES.
ES96111996T 1995-08-03 1996-07-25 Metodo para preparar 1-beta-d-arabinofuranosilcitosina. Expired - Lifetime ES2126971T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT95MI001715A IT1277425B1 (it) 1995-08-03 1995-08-03 Metodo per la preparazione della 1-b-d-arabinofuranosilcitosina

Publications (1)

Publication Number Publication Date
ES2126971T3 true ES2126971T3 (es) 1999-04-01

Family

ID=11372129

Family Applications (1)

Application Number Title Priority Date Filing Date
ES96111996T Expired - Lifetime ES2126971T3 (es) 1995-08-03 1996-07-25 Metodo para preparar 1-beta-d-arabinofuranosilcitosina.

Country Status (6)

Country Link
EP (1) EP0757056B1 (es)
JP (1) JPH09165396A (es)
AT (1) ATE173270T1 (es)
DE (1) DE69600958T2 (es)
ES (1) ES2126971T3 (es)
IT (1) IT1277425B1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1302004C (zh) * 2003-08-22 2007-02-28 浙江海正药业股份有限公司 一种阿糖胞苷的制备方法
CN101948492A (zh) * 2010-08-20 2011-01-19 河南师范大学 化学合成法生产阿糖胞苷的工艺
CN112552361A (zh) * 2020-12-30 2021-03-26 瀚晖制药有限公司 阿糖胞苷晶体、阿糖胞苷冻干粉剂及冻干方法
CN113292611B (zh) * 2021-06-25 2022-05-17 国药一心制药有限公司 一种阿糖胞苷的纯化方法
CN113735926B (zh) * 2021-09-14 2023-07-25 江苏香地化学有限公司 一种尿苷的合成工艺
CN117164646A (zh) * 2023-11-03 2023-12-05 广州市桐晖药业有限公司 一种阿糖胞苷的合成方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3116282A (en) 1960-04-27 1963-12-31 Upjohn Co Pyrimidine nucleosides and process
US3658788A (en) 1969-06-06 1972-04-25 Salk Inst For Biological Studi Aminooxazolines and products thereof and processes for synthesizing same
US3721664A (en) 1970-01-27 1973-03-20 Hoffmann La Roche Preparation of 5-cytosine nucleosides
US3868373A (en) 1970-01-27 1975-02-25 Hoffmann La Roche 4-Amino-5-fluoro-2-tri(lower alkyl) silyloxypyrimidines
JPS5010595B1 (es) 1970-09-18 1975-04-22
US3978042A (en) 1975-01-31 1976-08-31 The Upjohn Company Process for preparing cyclocytidine derivatives
US4754026A (en) 1985-06-04 1988-06-28 Takeda Chemical Industries, Ltd. Conversion of uracil derivatives to cytosine derivatives
JPH07103149B2 (ja) 1987-11-30 1995-11-08 ヤマサ醤油株式会社 シトシン誘導体の製造法
BR9106158A (pt) 1990-03-13 1993-03-16 Acic Canada Inc Processo para produzir 2,2'-o-ciclonucleosideos,nucleosideos e seus analogos

Also Published As

Publication number Publication date
DE69600958T2 (de) 1999-06-10
JPH09165396A (ja) 1997-06-24
ITMI951715A1 (it) 1997-02-03
ATE173270T1 (de) 1998-11-15
ITMI951715A0 (it) 1995-08-03
EP0757056B1 (en) 1998-11-11
DE69600958D1 (de) 1998-12-17
EP0757056A1 (en) 1997-02-05
IT1277425B1 (it) 1997-11-10

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