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IT1251158B - 13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES - Google Patents

13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES

Info

Publication number
IT1251158B
IT1251158B ITMI912222A ITMI912222A IT1251158B IT 1251158 B IT1251158 B IT 1251158B IT MI912222 A ITMI912222 A IT MI912222A IT MI912222 A ITMI912222 A IT MI912222A IT 1251158 B IT1251158 B IT 1251158B
Authority
IT
Italy
Prior art keywords
hydrogen
hydroxy
anthracyclines
morpholinyl
dihydro
Prior art date
Application number
ITMI912222A
Other languages
Italian (it)
Inventor
Antonino Suarato
Original Assignee
Erba Carlo Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Erba Carlo Spa filed Critical Erba Carlo Spa
Publication of ITMI912222A0 publication Critical patent/ITMI912222A0/en
Publication of ITMI912222A1 publication Critical patent/ITMI912222A1/en
Application granted granted Critical
Publication of IT1251158B publication Critical patent/IT1251158B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Glicosidi antraciclinici di formula A: (FORMULA ) dove R1 è un atomo di idrogeno, un gruppo idrossi o metossi; R2 o R3 rappresenta un gruppo idrossile e l'altro di R2 e R3 rappresenta un atomo di idrogeno; R4 è idrogeno o idrossi; sia R5 che R6 rappresentano idrogeno oppure uno di R5 e R6 rappresenta idrogeno e l'altro di R5 e R6 idrossi; R7 rappresenta un residuo alchilico inferiore lineare o ramificato o un residuo benzilico e loro sali farmaceuticamente accettabili sono agenti antitumorali.Anthracyclinic glycosides of formula A: (FORMULA) where R1 is a hydrogen atom, a hydroxy or methoxy group; R2 or R3 represents a hydroxyl group and the other of R2 and R3 represents a hydrogen atom; R4 is hydrogen or hydroxy; both R5 and R6 represent hydrogen or one of R5 and R6 represents hydrogen and the other of R5 and R6 hydroxy; R7 represents a linear or branched lower alkyl residue or a benzyl residue and their pharmaceutically acceptable salts are anticancer agents.

ITMI912222A 1990-09-12 1991-08-07 13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES IT1251158B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909019933A GB9019933D0 (en) 1990-09-12 1990-09-12 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines

Publications (3)

Publication Number Publication Date
ITMI912222A0 ITMI912222A0 (en) 1991-08-07
ITMI912222A1 ITMI912222A1 (en) 1992-03-13
IT1251158B true IT1251158B (en) 1995-05-04

Family

ID=10682082

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI912222A IT1251158B (en) 1990-09-12 1991-08-07 13-DIHYDRO-3 '- (2-alkoxy-4-morpholinyl) ANTHRACYCLINES

Country Status (4)

Country Link
JP (1) JP3068258B2 (en)
DE (1) DE4126475B4 (en)
GB (2) GB9019933D0 (en)
IT (1) IT1251158B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8742076B2 (en) 2008-02-01 2014-06-03 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
WO2010009124A2 (en) 2008-07-15 2010-01-21 Genentech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
RU2563638C2 (en) 2010-12-02 2015-09-20 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. Method of obtaining morpholinylanthracycline derivatives
RU2666356C2 (en) * 2013-04-29 2018-09-07 НЕРВИАНО МЕДИКАЛ САЙЕНСИЗ С.р.л. New morpholinyl anthracycline derivatives

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4464529A (en) * 1982-07-20 1984-08-07 Sri International Analogues of morpholinyl daunorubicin and morpholinyl doxorubicin
JPS59212499A (en) * 1983-05-13 1984-12-01 アドリヤ・ラボラトリ−ズ・インコ−ポレ−テツド 4-demethoxy-3'-deamino-3'(4-morpholinyl) derivative
GB2172594B (en) * 1985-03-22 1988-06-08 Erba Farmitalia New morpholino derivatives of daunorubicin and doxorubicin
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives

Also Published As

Publication number Publication date
GB2247885A (en) 1992-03-18
DE4126475B4 (en) 2005-09-15
ITMI912222A0 (en) 1991-08-07
GB2247885B (en) 1994-02-09
JP3068258B2 (en) 2000-07-24
JPH04247096A (en) 1992-09-03
ITMI912222A1 (en) 1992-03-13
DE4126475A1 (en) 1992-03-19
GB9117175D0 (en) 1991-09-25
GB9019933D0 (en) 1990-10-24

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970728