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GB2247885B - 13-Dihydro-3'-(2-alkoxy-4-morpholinyl)anthracyclines - Google Patents

13-Dihydro-3'-(2-alkoxy-4-morpholinyl)anthracyclines

Info

Publication number
GB2247885B
GB2247885B GB9117175A GB9117175A GB2247885B GB 2247885 B GB2247885 B GB 2247885B GB 9117175 A GB9117175 A GB 9117175A GB 9117175 A GB9117175 A GB 9117175A GB 2247885 B GB2247885 B GB 2247885B
Authority
GB
United Kingdom
Prior art keywords
anthracyclines
morpholinyl
dihydro
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
GB9117175A
Other versions
GB9117175D0 (en
GB2247885A (en
Inventor
Alberto Bargiotti
Daniela Faiardi
Antonino Suarato
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of GB9117175D0 publication Critical patent/GB9117175D0/en
Publication of GB2247885A publication Critical patent/GB2247885A/en
Application granted granted Critical
Publication of GB2247885B publication Critical patent/GB2247885B/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/24—Heterocyclic radicals containing oxygen or sulfur as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
GB9117175A 1990-09-12 1991-08-08 13-Dihydro-3'-(2-alkoxy-4-morpholinyl)anthracyclines Expired - Lifetime GB2247885B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB909019933A GB9019933D0 (en) 1990-09-12 1990-09-12 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines

Publications (3)

Publication Number Publication Date
GB9117175D0 GB9117175D0 (en) 1991-09-25
GB2247885A GB2247885A (en) 1992-03-18
GB2247885B true GB2247885B (en) 1994-02-09

Family

ID=10682082

Family Applications (2)

Application Number Title Priority Date Filing Date
GB909019933A Pending GB9019933D0 (en) 1990-09-12 1990-09-12 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines
GB9117175A Expired - Lifetime GB2247885B (en) 1990-09-12 1991-08-08 13-Dihydro-3'-(2-alkoxy-4-morpholinyl)anthracyclines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB909019933A Pending GB9019933D0 (en) 1990-09-12 1990-09-12 13-dihydro-3'-(2-alkoxy-4-morphlinyl)anthracyclines

Country Status (4)

Country Link
JP (1) JP3068258B2 (en)
DE (1) DE4126475B4 (en)
GB (2) GB9019933D0 (en)
IT (1) IT1251158B (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009099741A1 (en) 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
AU2009270988A1 (en) 2008-07-15 2010-01-21 Genentech, Inc. Anthracycline derivative conjugates, process for their preparation and their use as antitumor compounds
MX2013005972A (en) 2010-12-02 2013-08-09 Nerviano Medical Sciences Srl Process for the preparation of morpholinyl anthracycline derivatives.
CN105164138B (en) * 2013-04-29 2017-11-07 内尔维阿诺医学科学有限公司 new morpholinyl anthracycline derivatives

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124224A (en) * 1982-07-20 1984-02-15 Stanford Res Inst Int Derivatives of daunorubicin and doxorubicin
EP0128670A1 (en) * 1983-05-13 1984-12-19 Adria Laboratories, Inc. 4-Demethoxy-3'-deamino-3'(4-morpholinyl) derivatives of anthracycline anticancer antibiotics
US4672057A (en) * 1985-03-22 1987-06-09 Farmitalia Carlo Erba S.P.A. Morpholino derivatives of daunorubicin and doxorubicin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8905668D0 (en) * 1989-03-13 1989-04-26 Erba Carlo Spa New 3'-(4-morpholinyl)-and 3'-(2-methoxy-4-morpholinyl)-anthracycline derivatives

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2124224A (en) * 1982-07-20 1984-02-15 Stanford Res Inst Int Derivatives of daunorubicin and doxorubicin
EP0128670A1 (en) * 1983-05-13 1984-12-19 Adria Laboratories, Inc. 4-Demethoxy-3'-deamino-3'(4-morpholinyl) derivatives of anthracycline anticancer antibiotics
US4672057A (en) * 1985-03-22 1987-06-09 Farmitalia Carlo Erba S.P.A. Morpholino derivatives of daunorubicin and doxorubicin

Also Published As

Publication number Publication date
DE4126475B4 (en) 2005-09-15
GB9117175D0 (en) 1991-09-25
DE4126475A1 (en) 1992-03-19
GB9019933D0 (en) 1990-10-24
ITMI912222A0 (en) 1991-08-07
JPH04247096A (en) 1992-09-03
ITMI912222A1 (en) 1992-03-13
IT1251158B (en) 1995-05-04
JP3068258B2 (en) 2000-07-24
GB2247885A (en) 1992-03-18

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Legal Events

Date Code Title Description
PE20 Patent expired after termination of 20 years

Expiry date: 20110807